MCID: RMN001
MIFTS: 33

Rumination Disorder

Categories: Mental diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Rumination Disorder

MalaCards integrated aliases for Rumination Disorder:

Name: Rumination Disorder 12 20 15
Rumination Syndrome 73 20 44
Psychogenic Rumination 12 70
Rumination Disorders 70

Classifications:



External Ids:

Disease Ontology 12 DOID:11507
ICD9CM 34 307.53
MeSH 44 D000079562
NCIt 50 C92567
SNOMED-CT 67 37941009
UMLS 70 C0154575 C3665436

Summaries for Rumination Disorder

GARD : 20 Rumination disorder is the backward flow of recently eaten food from the stomach to the mouth. The food is then re-chewed and swallowed or spat out. A non-purposeful contraction of stomach muscles is involved in rumination. It may be initially triggered by a viral illness, emotional distress, or physical injury. In many cases, no underlying trigger is identified. Behavioral therapy is the mainstay of treatment. .

MalaCards based summary : Rumination Disorder, also known as rumination syndrome, is related to gastroesophageal reflux and gastroparesis. An important gene associated with Rumination Disorder is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are DNA Damage/Telomere Stress Induced Senescence and Cell cycle_Chromosome condensation in prometaphase. The drugs Baclofen and Neurotransmitter Agents have been mentioned in the context of this disorder.

Disease Ontology : 12 An eating disorder that is characterized by effortless regurgitation of most meals following consumption.

Wikipedia : 73 Rumination syndrome, or merycism, is a chronic motility disorder characterized by effortless... more...

Related Diseases for Rumination Disorder

Diseases related to Rumination Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 gastroesophageal reflux 30.5 MLN ATP4A ATP12A
2 gastroparesis 30.1 MLNR MLN
3 pylorospasm 29.9 MLNR MLN
4 superior mesenteric artery syndrome 29.7 MLNR ATP4A ATP12A
5 constipation 29.3 MLNR MLN ATP4A ATP12A
6 vagus nerve disease 10.2 ATP4A ATP12A
7 necrotizing gastritis 10.2 ATP4A ATP12A
8 scalp dermatosis 10.2 ATP4A ATP12A
9 hemangioma of intra-abdominal structure 10.2 ATP4A ATP12A
10 acquired gastric outlet stenosis 10.2 ATP4A ATP12A
11 lingual goiter 10.2 ATP4A ATP12A
12 displacement of cardia through esophageal hiatus 10.2 ATP4A ATP12A
13 bacterial esophagitis 10.2 ATP4A ATP12A
14 cascade stomach 10.2 ATP4A ATP12A
15 benzylpenicillin allergy 10.2 ATP4A ATP12A
16 median arcuate ligament syndrome 10.2 ATP4A ATP12A
17 afferent loop syndrome 10.2 ATP4A ATP12A
18 cervix erosion 10.2 ATP4A ATP12A
19 angiodysplasia of intestine 10.2 ATP4A ATP12A
20 angiodysplasia 10.2 ATP4A ATP12A
21 granulomatous gastritis 10.2 ATP4A ATP12A
22 laryngeal tuberculosis 10.2 ATP4A ATP12A
23 fungal esophagitis 10.2 ATP4A ATP12A
24 dieulafoy lesion 10.2 ATP4A ATP12A
25 esophagus melanoma 10.2 ATP4A ATP12A
26 cefuroxime allergy 10.2 ATP4A ATP12A
27 emphysematous cholecystitis 10.2 ATP4A ATP12A
28 gastric gastrinoma 10.2 ATP4A ATP12A
29 chronic laryngitis 10.2 ATP4A ATP12A
30 laryngitis 10.2 ATP4A ATP12A
31 peptic ulcer perforation 10.2 ATP4A ATP12A
32 viral laryngitis 10.2 ATP4A ATP12A
33 gastroduodenal crohn's disease 10.2 ATP4A ATP12A
34 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 ATP4A ATP12A
35 central nervous system origin vertigo 10.2 ATP4A ATP12A
36 internal hemorrhoid 10.2 ATP4A ATP12A
37 hemorrhoid 10.2 ATP4A ATP12A
38 acute laryngitis 10.2 ATP4A ATP12A
39 gastroduodenitis 10.2 ATP4A ATP12A
40 duodenitis 10.2 ATP4A ATP12A
41 chronic intestinal vascular insufficiency 10.2 ATP4A ATP12A
42 barbiturate abuse 10.2 ATP4A ATP12A
43 duodenal gastrinoma 10.2 ATP4A ATP12A
44 gastric dilatation 10.2 ATP4A ATP12A
45 gastric hemangioma 10.2 ATP4A ATP12A
46 polycystic echinococcosis 10.2 ATP4A ATP12A
47 diclofenac allergy 10.2 ATP4A ATP12A
48 lymphocytic gastritis 10.2 ATP4A ATP12A
49 x-linked chondrodysplasia punctata 1 10.2 ATP4A ATP12A
50 mediastinitis 10.2 ATP4A ATP12A

Graphical network of the top 20 diseases related to Rumination Disorder:



Diseases related to Rumination Disorder

Symptoms & Phenotypes for Rumination Disorder

Drugs & Therapeutics for Rumination Disorder

Drugs for Rumination Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Baclofen Approved Phase 4 1134-47-0 2284
2 Neurotransmitter Agents Phase 4
3 GABA Agonists Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Double-blind, Placebo-controlled, Cross-over Study Using Baclofen in the Treatment of Rumination Syndrome Completed NCT03113396 Phase 4 Baclofen;Placebo oral capsule
2 A Pilot Study of Cognitive-Behavioral Therapy for Rumination Disorder Unknown status NCT03113682
3 Rumination Syndrome: Role of Vagal Tone and Effect of Respiratory Manoeuvres on Severity and Frequency of Rumination Unknown status NCT03912636
4 A Pilot Study of Cognitive-Behavioral Therapy for Rumination Disorder (CBT-RD) Completed NCT03062696
5 Valoración Objetiva y Tratamiento de la rumiación Completed NCT02402946 Placebo
6 Valoración Objetiva y Tratamiento de la rumiación. Completed NCT02214472 Placebo
7 Treament of Rumination Recruiting NCT04167371

Search NIH Clinical Center for Rumination Disorder

Cochrane evidence based reviews: rumination syndrome

Genetic Tests for Rumination Disorder

Anatomical Context for Rumination Disorder

Publications for Rumination Disorder

Articles related to Rumination Disorder:

(show top 50) (show all 151)
# Title Authors PMID Year
1
ESNM/ANMS consensus paper: Diagnosis and management of refractory gastro-esophageal reflux disease. 61
33368919 2021
2
Detection and characteristics of rumination syndrome in patients presenting for gastric symptom evaluation. 61
33729638 2021
3
Fifteen-minute consultation: Childhood rumination syndrome. 61
33579743 2021
4
Rumination syndrome. A review article. 61
33602544 2021
5
Prevalence of behavioral disorders in patients with vonoprazan-refractory reflux symptoms. 61
33247348 2021
6
Low prevalence of infantile functional gastrointestinal disorders (FGIDs) in a multi-ethnic Asian population. 61
32891528 2021
7
New developments in esophageal function testing and esophageal manifestations of connective tissue disorders. 61
32627210 2020
8
The gastro-sphincteric pressure gradient: A new parameter to diagnose a rumination episode. 61
33350555 2020
9
Comprehensive Cognitive-Behavioral Interventions Augment Diaphragmatic Breathing for Rumination Syndrome: A Proof-of-Concept Trial. 61
33175346 2020
10
Rumination syndrome and gastroparesis: Linked entities? 61
33261941 2020
11
Rumination syndrome: Assessment of vagal tone during and after meals and during diaphragmatic breathing. 61
32383546 2020
12
Cognitive-behavioral therapy for avoidant/restrictive food intake disorder: Feasibility, acceptability, and proof-of-concept for children and adolescents. 61
32776570 2020
13
Screening for functional gastrointestinal disorders in children with epilepsy. 61
32629413 2020
14
The role of ambulatory 24-hour esophageal manometry in clinical practice. 61
32391594 2020
15
Outcomes of Treating Rumination Syndrome with a Tricyclic Antidepressant and Diaphragmatic Breathing. 61
32381269 2020
16
Chronic vomiting in children: A prospective study reveals rumination syndrome is an important etiology that is underdiagnosed and untreated. 61
32436177 2020
17
Eating disorders. 61
32171414 2020
18
Rumination Syndrome in Children Presenting With Refractory Gastroesophageal Reflux Symptoms. 61
32079888 2020
19
Baseline Impedance Measured During High-resolution Esophageal Impedance Manometry in Patients With Rumination Syndrome is as Abnormal as in Patients With GERD. 61
30575633 2020
20
Rumination Syndrome: Recognition and Treatment. 61
31960280 2020
21
Persistent Postprandial Regurgitation vs Rumination in Patients With Refractory Gastroesophageal Reflux Disease Symptoms: Identification of a Distinct Rumination Pattern Using Ambulatory Impedance-pH Monitoring. 61
31246694 2019
22
The Utility of Esophageal Motility Testing in Gastroesophageal Reflux Disease (GERD). 61
31289922 2019
23
Rumination syndrome: when to suspect and how to treat. 61
31116102 2019
24
Continuing Medical Education Questions: April 2019. 61
30950858 2019
25
Diagnosis and Treatment of Rumination Syndrome: A Critical Review. 61
30789419 2019
26
Development of the Pica, ARFID, and Rumination Disorder Interview, a multi-informant, semi-structured interview of feeding disorders across the lifespan: A pilot study for ages 10-22. 61
30312485 2019
27
Gastrointestinal: Severe ineffective esophageal motility presenting as rumination syndrome. 61
30357903 2019
28
Duodenal Pathology in Patients with Rumination Syndrome: Duodenal Eosinophilia and Increased Intraepithelial Lymphocytes. 61
30478768 2019
29
Feeding and Eating Disorders in Children. 61
30704636 2019
30
Evaluation of Patients with Suspected Gastroparesis. 61
30396527 2019
31
Refractory GERD, beyond proton pump inhibitors. 61
30240968 2018
32
Utility of Esophageal High-Resolution Manometry in Clinical Practice: First, Do HRM. 61
30276571 2018
33
Prevalence of pica and rumination behaviors in German children aged 7-14 and their associations with feeding, eating, and general psychopathology: a population-based study. 61
29675593 2018
34
Letter in response to Rosen et al.: An interesting pediatric case of rumination syndrome. 61
30259611 2018
35
Diagnosis and Treatment of Rumination Syndrome. 61
29902642 2018
36
Eating disorders-Related hospitalizations in Portugal: A nationwide study from 2000 to 2014. 61
30265756 2018
37
[Rumination syndrome: Diagnostic and therapeutic difficulties of a not so infrequent disorder]. 61
29699934 2018
38
Prevalence in primary school youth of pica and rumination behavior: The understudied feeding disorders. 61
30175409 2018
39
Rumination Syndrome: Unknown Pathology Easy to Diagnose With High-resolution Impedance Manometry. 61
29969863 2018
40
Diagnosis and Evaluation of Eating Disorders in the Pediatric Patient. 61
29898236 2018
41
Dietary assessment and counseling for dental erosion. 61
29389338 2018
42
[Rumination syndrome: Diagnostic and therapeutic difficulties of a not so uncommon disorder]. 61
28460821 2018
43
A Randomized Double-Blind, Placebo-Controlled, Cross-Over Study Using Baclofen in the Treatment of Rumination Syndrome. 61
29206813 2018
44
Long-term Follow-up of Adolescents Treated for Rumination Syndrome in an Inpatient Setting. 61
28505048 2018
45
[Rumination]. 61
29277089 2017
46
High-resolution Esophageal Manometry Patterns in Children and Adolescents With Rumination Syndrome. 61
29072581 2017
47
[Functional gastrointestinal disorders in children and adolescents. The Rome IV criteria]. 61
28875974 2017
48
[Functional gastrointestinal disorders in neonate and toddler. The Rome IV criteria]. 61
28805200 2017
49
An 8-item short form of the Eating Disorder Examination-Questionnaire adapted for children (ChEDE-Q8). 61
28122128 2017
50
High Cost and Low Yield: The Diagnostic Evaluation of Rumination Syndrome in Pediatrics. 61
28256211 2017

Variations for Rumination Disorder

Expression for Rumination Disorder

Search GEO for disease gene expression data for Rumination Disorder.

Pathways for Rumination Disorder

Pathways related to Rumination Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.68 H2AC18 H1-5 H1-2
2 10.78 H1-5 H1-2
3
Show member pathways
10.37 H1-5 H1-2
4 9.83 H1-5 H1-2

GO Terms for Rumination Disorder

Cellular components related to Rumination Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 euchromatin GO:0000791 8.96 H1-5 H1-2
2 nucleosome GO:0000786 8.8 H2AC18 H1-5 H1-2

Biological processes related to Rumination Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.46 ATP4A ATP12A
2 chromosome condensation GO:0030261 9.43 H1-5 H1-2
3 cellular sodium ion homeostasis GO:0006883 9.4 ATP4A ATP12A
4 negative regulation of DNA recombination GO:0045910 9.37 H1-5 H1-2
5 nucleosome positioning GO:0016584 9.32 H1-5 H1-2
6 sodium ion export across plasma membrane GO:0036376 9.26 ATP4A ATP12A
7 negative regulation of chromatin silencing GO:0031936 9.16 H1-5 H1-2
8 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
9 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP4A ATP12A

Molecular functions related to Rumination Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin DNA binding GO:0031490 9.32 H1-5 H1-2
2 nucleosomal DNA binding GO:0031492 9.26 H1-5 H1-2
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
4 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
5 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Rumination Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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