MCID: SCR024
MIFTS: 30

Sacrococcygeal Teratoma

Categories: Rare diseases

Aliases & Classifications for Sacrococcygeal Teratoma

MalaCards integrated aliases for Sacrococcygeal Teratoma:

Name: Sacrococcygeal Teratoma 38 53 59 29 73

Classifications:



External Ids:

Orphanet 59 ORPHA494421
UMLS 73 C0559459

Summaries for Sacrococcygeal Teratoma

NIH Rare Diseases : 53 A sacrococcygeal teratoma is a tumor that grows at the base of the spine in a developing fetus.  It occurs in one in 40,000 newborns and girls are four times more likely to be affected than boys.  Though it is usually benign, there is a possibility that the teratoma could become malignant.  As such, the recommended treatment of a teratoma is complete removal of the tumor by surgery, performed soon after the birth.  If not all of the tumor is removed during the initial surgery, the teratoma may grow back (recur) and additional surgeries may be needed.  Studies have found that sacrococcygeal teratomas recur in up to 22% of cases.

MalaCards based summary : Sacrococcygeal Teratoma is related to teratoma and down syndrome. An important gene associated with Sacrococcygeal Teratoma is CGA (Glycoprotein Hormones, Alpha Polypeptide), and among its related pathways/superpathways is Glucocorticoid receptor regulatory network. Affiliated tissues include Primitive Streak, heart and pituitary.

Wikipedia : 76 Sacrococcygeal teratoma (SCT) is a type of tumor known as a teratoma that develops at the base of the... more...

Related Diseases for Sacrococcygeal Teratoma

Diseases related to Sacrococcygeal Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 teratoma 31.5 AFP CGA MNX1
2 down syndrome 29.7 AFP CGB7
3 neural tube defects 29.4 AFP MNX1
4 endodermal sinus tumor 10.2
5 hydrops fetalis, nonimmune, and/or atrial septal defect 10.2
6 fetal edema 10.2
7 hydrops fetalis 10.2
8 neuroblastoma 10.1
9 hemangioma 10.1
10 cardiac arrest 10.1
11 cornelia de lange syndrome 10.1
12 adenocarcinoma 10.1
13 fibrosarcoma 10.1
14 ring chromosome 21 10.1
15 schinzel giedion syndrome 10.1
16 ovarian mixed germ cell neoplasm 10.0 AFP CGA
17 nonseminomatous germ cell tumor 10.0 AFP CGB7
18 ectopic pregnancy 10.0 CGA CGB7
19 polyembryoma 10.0 AFP CGA
20 mixed germ cell tumor 10.0 AFP CGA
21 testicular seminoma 10.0 AFP CGA
22 chromosomal triplication 10.0 AFP CGA
23 orofaciodigital syndrome viii 10.0 AFP CGA
24 hydrocele 10.0 AFP CGA
25 prune belly syndrome 9.9
26 sotos syndrome 1 9.9
27 diaphragmatic hernia, congenital 9.9
28 klippel-trenaunay-weber syndrome 9.9
29 currarino syndrome 9.9
30 pelvic organ prolapse 9.9
31 proteus syndrome 9.9
32 renal hypodysplasia/aplasia 1 9.9
33 vater/vacterl association 9.9
34 anemia, autoimmune hemolytic 9.9
35 gastroschisis 9.9
36 aicardi syndrome 9.9
37 lipomyelomeningocele 9.9
38 wilms tumor 6 9.9
39 renal hypodysplasia/aplasia 3 9.9
40 congestive heart failure 9.9
41 hemolytic anemia 9.9
42 hydrocephalus 9.9
43 scoliosis 9.9
44 myelomeningocele 9.9
45 thrombosis 9.9
46 meningocele 9.9
47 hydronephrosis 9.9
48 cauda equina syndrome 9.9
49 conn's syndrome 9.9
50 neurogenic bladder 9.9

Graphical network of the top 20 diseases related to Sacrococcygeal Teratoma:



Diseases related to Sacrococcygeal Teratoma

Symptoms & Phenotypes for Sacrococcygeal Teratoma

Drugs & Therapeutics for Sacrococcygeal Teratoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Characterization of At-risk Population for Pre-sacral Tumor in CURRARINO Syndrome Completed NCT00780117

Search NIH Clinical Center for Sacrococcygeal Teratoma

Genetic Tests for Sacrococcygeal Teratoma

Genetic tests related to Sacrococcygeal Teratoma:

# Genetic test Affiliating Genes
1 Sacrococcygeal Teratoma 29

Anatomical Context for Sacrococcygeal Teratoma

MalaCards organs/tissues related to Sacrococcygeal Teratoma:

41
Heart, Pituitary, Liver, Bone, Eye, Spinal Cord, Placenta
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Sacrococcygeal Teratoma:
# Tissue Anatomical CompartmentCell Relevance
1 Primitive Streak Primitive Streak Affected by disease

Publications for Sacrococcygeal Teratoma

Articles related to Sacrococcygeal Teratoma:

(show top 50) (show all 463)
# Title Authors Year
1
High Tumor Volume to Fetal Weight Ratio Is Associated with Worse Fetal Outcomes and Increased Maternal Risk in Fetuses with Sacrococcygeal Teratoma. ( 29495013 )
2018
2
Extraspinal sacrococcygeal ependymoma masquerading as sacrococcygeal teratoma in the pediatric patient. ( 29138922 )
2018
3
Long-Term Outcome of Sacrococcygeal Teratoma: A Controlled Cohort Study of Urinary Tract and Bowel Dysfunction and Predictors of Poor Outcome. ( 29656864 )
2018
4
The incidence of associated abnormalities in patients with sacrococcygeal teratoma. ( 29453131 )
2018
5
High-dose Chemotherapy is Efficacious and Well Tolerated in a Toddler With Aicardi Syndrome and Malignant Sacrococcygeal Teratoma. ( 29420371 )
2018
6
A giant sacrococcygeal teratoma in adult female: A case report. ( 30522078 )
2018
7
Surgical treatment of a type IV cystic sacrococcygeal teratoma with intraspinal extension utilizing a posterior-anterior-posterior approach: a case report. ( 29368306 )
2018
8
Antenatal Prediction of Neonatal Survival in Sacrococcygeal Teratoma. ( 29399854 )
2018
9
Half-life of alpha-fetoprotein in neonatal sacrococcygeal teratoma. ( 30249359 )
2018
10
Acquired Urethrovaginal Fistula and Urethral Atresia in a Patient with a Sacrococcygeal Teratoma. ( 30297116 )
2018
11
Late effects in patients with sacrococcygeal teratoma: A single center series. ( 30346857 )
2018
12
Functional outcome and health-related quality of life in patients with sacrococcygeal teratoma - a Swedish multicenter study. ( 30420172 )
2018
13
Giant sacrococcygeal teratoma: Management concerns with reporting of a rare occurrence of venous air embolism. ( 28217075 )
2017
14
Fetus in Fetu in Lieu of a Sacrococcygeal Teratoma: A Case Illuminating the Utility of Serial Prenatal Sonographic Examinations in Diagnosis. ( 28026891 )
2017
15
Sacrococcygeal teratoma presenting with vaginal discharge and polyp in an infant. ( 29269272 )
2017
16
Successful Postnatal Management of Ruptured Giant Sacrococcygeal Teratoma. ( 28770134 )
2017
17
Risk factors for perioperative mortality and transfusion in sacrococcygeal teratoma resections. ( 28321971 )
2017
18
Pediatric Intraocular Immature Teratoma Associated With Sacrococcygeal Teratoma. ( 28521629 )
2017
19
Sacrococcygeal Teratoma in a Seven-Day-Old Child with Pulmonary Differentiation. ( 28969230 )
2017
20
Sacrococcygeal teratoma: late recurrence warrants long-term surveillance. ( 28894920 )
2017
21
Unilateral renal agenesis with subseptate uterus and sacrococcygeal teratoma: A unique triad. ( 29089677 )
2017
22
Early Delivery of Sacrococcygeal Teratoma with Intraspinal Extension. ( 28463844 )
2017
23
Analysis of Recurrent Sacrococcygeal Teratoma in Children: Clinical Features, Relapse Risks, and Anorectal Functional Sequelae. ( 28042962 )
2017
24
Prune Belly Syndrome with Sacrococcygeal Teratoma. ( 28593491 )
2017
25
Adult sacrococcygeal teratoma with coccygectomy: A case report with a review of the literature. ( 29184711 )
2017
26
Acromegaly and Cushing's syndrome caused by a neuroendocrine tumor arising within a sacrococcygeal teratoma. ( 29152267 )
2017
27
Mucinous tumor arising in a giant sacrococcygeal teratoma: A rare case report. ( 29381973 )
2017
28
Prenatal diagnosis of tethered spinal cord associated with sacrococcygeal teratoma. ( 26892808 )
2016
29
Type IV Sacrococcygeal Teratoma Displacing the Urinary Bladder: Unique Magnetic Resonance Imaging. ( 27413571 )
2016
30
VACTERL Association with Sacrococcygeal Teratoma. ( 27567656 )
2016
31
Pediatric intraocular immature teratoma associated with sacrococcygeal teratoma: case report and review of the literature. ( 27385488 )
2016
32
Hydrocephalus secondary to chemotherapy in a case of prenatally diagnosed giant immature grade 3 sacrococcygeal teratoma: A case report and literature review. ( 27787388 )
2016
33
Patient-Reported Defecation and Micturition Problems Among Adults Treated for Sacrococcygeal Teratoma During Childhood-The Need for New Surveillance Strategies. ( 26739142 )
2016
34
Hemorrhage is the most common cause of neonatal mortality in patients with sacrococcygeal teratoma. ( 27502009 )
2016
35
Use of intraoperative lateral pelvic X-ray to localize and ensure coccyx removal during sacrococcygeal teratoma resection. ( 27858188 )
2016
36
Sacrococcygeal Teratoma: Mistreated With Repeated Aspirations. ( 27398327 )
2016
37
Sacrococcygeal Teratoma associated with Trisomy 13. ( 27398323 )
2016
38
Acardiac twin pregnancies part II: Fetal risk of chorangioma and sacrococcygeal teratoma predicted by pump/acardiac umbilical vein diameters. ( 27273226 )
2016
39
Benign sacrococcygeal teratoma incidentally found on routine scoliosis radiographs in a 12-year-old female: a case report. ( 27069263 )
2016
40
Anaesthestic management of sacrococcygeal teratoma in infants. ( 27212735 )
2016
41
Evaluation of chemotherapeutic sequelae and quality of life in survivors of malignant sacrococcygeal teratoma. ( 26667016 )
2016
42
Magnetic Resonance Imaging Verification of a Case of Sacrococcygeal Teratoma. ( 28983369 )
2016
43
Sexual function after treatment for sacrococcygeal teratoma during childhood. ( 26460155 )
2015
44
Cornelia de Lange syndrome due to mosaic NIPBL mutation: antenatal presentation with sacrococcygeal teratoma. ( 26276849 )
2015
45
Sacrococcygeal Teratoma with Yolk Sac Component in a Neonate. ( 26290815 )
2015
46
Sacrococcygeal teratoma with ectopic immature renal tissue. ( 25673616 )
2015
47
Sacrococcygeal teratoma with complete adrenal gland. ( 26881658 )
2015
48
Benign and Infected Sacrococcygeal Teratoma in a 13-year-old Girl. ( 26064810 )
2015
49
Predictors of poor prognosis in prenatally diagnosed sacrococcygeal teratoma: A multiinstitutional review. ( 25783370 )
2015
50
A Huge Fetal Sacrococcygeal Teratoma with a Vascular Disruption Sequence. ( 26029981 )
2015

Variations for Sacrococcygeal Teratoma

Expression for Sacrococcygeal Teratoma

Search GEO for disease gene expression data for Sacrococcygeal Teratoma.

Pathways for Sacrococcygeal Teratoma

Pathways related to Sacrococcygeal Teratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.54 AFP CGA

GO Terms for Sacrococcygeal Teratoma

Molecular functions related to Sacrococcygeal Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 CGA CGB7

Sources for Sacrococcygeal Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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