MCID: SCR024
MIFTS: 31

Sacrococcygeal Teratoma

Categories: Rare diseases

Aliases & Classifications for Sacrococcygeal Teratoma

MalaCards integrated aliases for Sacrococcygeal Teratoma:

Name: Sacrococcygeal Teratoma 38 53 59 29 73

Classifications:



External Ids:

Orphanet 59 ORPHA494421
UMLS 73 C0559459

Summaries for Sacrococcygeal Teratoma

NIH Rare Diseases : 53 A sacrococcygeal teratoma is a tumor that grows at the base of the spine in a developing fetus.  It occurs in one in 40,000 newborns and girls are four times more likely to be affected than boys.  Though it is usually benign, there is a possibility that the teratoma could become malignant.  As such, the recommended treatment of a teratoma is complete removal of the tumor by surgery, performed soon after the birth.  If not all of the tumor is removed during the initial surgery, the teratoma may grow back (recur) and additional surgeries may be needed.  Studies have found that sacrococcygeal teratomas recur in up to 22% of cases.

MalaCards based summary : Sacrococcygeal Teratoma is related to teratoma and down syndrome. An important gene associated with Sacrococcygeal Teratoma is MNX1 (Motor Neuron And Pancreas Homeobox 1), and among its related pathways/superpathways is Glucocorticoid receptor regulatory network. Affiliated tissues include Primitive Streak, heart and pituitary.

Wikipedia : 76 Sacrococcygeal teratoma (SCT) is a type of tumor known as a teratoma that develops at the base of the... more...

Related Diseases for Sacrococcygeal Teratoma

Diseases related to Sacrococcygeal Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 teratoma 30.1 AFP CGA MNX1
2 down syndrome 28.5 AFP CGB7
3 neural tube defects 28.2 AFP MNX1
4 endodermal sinus tumor 10.1
5 hydrops fetalis, nonimmune, and/or atrial septal defect 10.0
6 vaginitis 10.0
7 fetal edema 10.0
8 hydrops fetalis 10.0
9 neuroblastoma 9.9
10 cardiac arrest 9.9
11 cornelia de lange syndrome 9.9
12 urethritis 9.9
13 adenocarcinoma 9.9
14 fibrosarcoma 9.9
15 adrenal gland hyperfunction 9.9
16 placenta disease 9.9
17 type i 9.9
18 ring chromosome 21 9.9
19 schinzel giedion syndrome 9.9
20 prune belly syndrome 9.8
21 sotos syndrome 1 9.8
22 diaphragmatic hernia, congenital 9.8
23 klippel-trenaunay-weber syndrome 9.8
24 currarino syndrome 9.8
25 pelvic organ prolapse 9.8
26 proteus syndrome 9.8
27 renal hypodysplasia/aplasia 1 9.8
28 vater/vacterl association 9.8
29 anemia, autoimmune hemolytic 9.8
30 chordoma 9.8
31 gastroschisis 9.8
32 aicardi syndrome 9.8
33 aging 9.8
34 wilms tumor 5 9.8
35 lipomyelomeningocele 9.8
36 wilms tumor 6 9.8
37 renal hypodysplasia/aplasia 3 9.8
38 congestive heart failure 9.8
39 hemangioma 9.8
40 hemolytic anemia 9.8
41 hydrocephalus 9.8
42 scoliosis 9.8
43 thrombosis 9.8
44 meningocele 9.8
45 hydronephrosis 9.8
46 cauda equina syndrome 9.8
47 conn's syndrome 9.8
48 neurogenic bladder 9.8
49 vacterl association 9.8
50 neuroendocrine tumor 9.8

Graphical network of the top 20 diseases related to Sacrococcygeal Teratoma:



Diseases related to Sacrococcygeal Teratoma

Symptoms & Phenotypes for Sacrococcygeal Teratoma

Drugs & Therapeutics for Sacrococcygeal Teratoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Characterization of At-risk Population for Pre-sacral Tumor in CURRARINO Syndrome Completed NCT00780117

Search NIH Clinical Center for Sacrococcygeal Teratoma

Genetic Tests for Sacrococcygeal Teratoma

Genetic tests related to Sacrococcygeal Teratoma:

# Genetic test Affiliating Genes
1 Sacrococcygeal Teratoma 29

Anatomical Context for Sacrococcygeal Teratoma

MalaCards organs/tissues related to Sacrococcygeal Teratoma:

41
Heart, Pituitary, Uterus, Placenta, Adrenal Gland, Liver, Bone
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Sacrococcygeal Teratoma:
# Tissue Anatomical CompartmentCell Relevance
1 Primitive Streak Primitive Streak Affected by disease

Publications for Sacrococcygeal Teratoma

Articles related to Sacrococcygeal Teratoma:

(show top 50) (show all 451)
# Title Authors Year
1
High Tumor Volume to Fetal Weight Ratio Is Associated with Worse Fetal Outcomes and Increased Maternal Risk in Fetuses with Sacrococcygeal Teratoma. ( 29495013 )
2018
2
Extraspinal sacrococcygeal ependymoma masquerading as sacrococcygeal teratoma in the pediatric patient. ( 29138922 )
2018
3
Long-Term Outcome of Sacrococcygeal Teratoma: A Controlled Cohort Study of Urinary Tract and Bowel Dysfunction and Predictors of Poor Outcome. ( 29656864 )
2018
4
The incidence of associated abnormalities in patients with sacrococcygeal teratoma. ( 29453131 )
2018
5
High-dose Chemotherapy is Efficacious and Well Tolerated in a Toddler With Aicardi Syndrome and Malignant Sacrococcygeal Teratoma. ( 29420371 )
2018
6
Antenatal Prediction of Neonatal Survival in Sacrococcygeal Teratoma. ( 29399854 )
2018
7
Surgical treatment of a type IV cystic sacrococcygeal teratoma with intraspinal extension utilizing a posterior-anterior-posterior approach: a case report. ( 29368306 )
2018
8
Giant sacrococcygeal teratoma: Management concerns with reporting of a rare occurrence of venous air embolism. ( 28217075 )
2017
9
Fetus in Fetu in Lieu of a Sacrococcygeal Teratoma: A Case Illuminating the Utility of Serial Prenatal Sonographic Examinations in Diagnosis. ( 28026891 )
2017
10
Sacrococcygeal teratoma presenting with vaginal discharge and polyp in an infant. ( 29269272 )
2017
11
Successful Postnatal Management of Ruptured Giant Sacrococcygeal Teratoma. ( 28770134 )
2017
12
Risk factors for perioperative mortality and transfusion in sacrococcygeal teratoma resections. ( 28321971 )
2017
13
Pediatric Intraocular Immature Teratoma Associated With Sacrococcygeal Teratoma. ( 28521629 )
2017
14
Sacrococcygeal Teratoma in a Seven-Day-Old Child with Pulmonary Differentiation. ( 28969230 )
2017
15
Sacrococcygeal teratoma: late recurrence warrants long-term surveillance. ( 28894920 )
2017
16
Unilateral renal agenesis with subseptate uterus and sacrococcygeal teratoma: A unique triad. ( 29089677 )
2017
17
Early Delivery of Sacrococcygeal Teratoma with Intraspinal Extension. ( 28463844 )
2017
18
Analysis of Recurrent Sacrococcygeal Teratoma in Children: Clinical Features, Relapse Risks, and Anorectal Functional Sequelae. ( 28042962 )
2017
19
Prune Belly Syndrome with Sacrococcygeal Teratoma. ( 28593491 )
2017
20
Adult sacrococcygeal teratoma with coccygectomy: A case report with a review of the literature. ( 29184711 )
2017
21
Acromegaly and Cushing's syndrome caused by a neuroendocrine tumor arising within a sacrococcygeal teratoma. ( 29152267 )
2017
22
Mucinous tumor arising in a giant sacrococcygeal teratoma: A rare case report. ( 29381973 )
2017
23
Prenatal diagnosis of tethered spinal cord associated with sacrococcygeal teratoma. ( 26892808 )
2016
24
Type IV Sacrococcygeal Teratoma Displacing the Urinary Bladder: Unique Magnetic Resonance Imaging. ( 27413571 )
2016
25
VACTERL Association with Sacrococcygeal Teratoma. ( 27567656 )
2016
26
Pediatric intraocular immature teratoma associated with sacrococcygeal teratoma: case report and review of the literature. ( 27385488 )
2016
27
Hydrocephalus secondary to chemotherapy in a case of prenatally diagnosed giant immature grade 3 sacrococcygeal teratoma: A case report and literature review. ( 27787388 )
2016
28
Patient-Reported Defecation and Micturition Problems Among Adults Treated for Sacrococcygeal Teratoma During Childhood-The Need for New Surveillance Strategies. ( 26739142 )
2016
29
Hemorrhage is the most common cause of neonatal mortality in patients with sacrococcygeal teratoma. ( 27502009 )
2016
30
Use of intraoperative lateral pelvic X-ray to localize and ensure coccyx removal during sacrococcygeal teratoma resection. ( 27858188 )
2016
31
Sacrococcygeal Teratoma: Mistreated With Repeated Aspirations. ( 27398327 )
2016
32
Sacrococcygeal Teratoma associated with Trisomy 13. ( 27398323 )
2016
33
Acardiac twin pregnancies part II: Fetal risk of chorangioma and sacrococcygeal teratoma predicted by pump/acardiac umbilical vein diameters. ( 27273226 )
2016
34
Benign sacrococcygeal teratoma incidentally found on routine scoliosis radiographs in a 12-year-old female: a case report. ( 27069263 )
2016
35
Anaesthestic management of sacrococcygeal teratoma in infants. ( 27212735 )
2016
36
Evaluation of chemotherapeutic sequelae and quality of life in survivors of malignant sacrococcygeal teratoma. ( 26667016 )
2016
37
Sexual function after treatment for sacrococcygeal teratoma during childhood. ( 26460155 )
2015
38
Cornelia de Lange syndrome due to mosaic NIPBL mutation: antenatal presentation with sacrococcygeal teratoma. ( 26276849 )
2015
39
Sacrococcygeal Teratoma with Yolk Sac Component in a Neonate. ( 26290815 )
2015
40
Sacrococcygeal teratoma with ectopic immature renal tissue. ( 25673616 )
2015
41
Sacrococcygeal teratoma with complete adrenal gland. ( 26881658 )
2015
42
Benign and Infected Sacrococcygeal Teratoma in a 13-year-old Girl. ( 26064810 )
2015
43
Predictors of poor prognosis in prenatally diagnosed sacrococcygeal teratoma: A multiinstitutional review. ( 25783370 )
2015
44
A Huge Fetal Sacrococcygeal Teratoma with a Vascular Disruption Sequence. ( 26029981 )
2015
45
Sacrococcygeal teratoma in a female newborn with clinical features of trisomy 13: a case report from Central Africa. ( 26715863 )
2015
46
Quality of life in adulthood after resection of a sacrococcygeal teratoma in childhood: a Dutch multicentre study. ( 25634960 )
2015
47
Sacrococcygeal teratoma: case report. ( 26079985 )
2015
48
Adult Sacrococcygeal Teratoma: The third leg: A rare case report in a 25 year old man. ( 26275739 )
2015
49
Sonographic features of congenital infantile fibrosarcoma that appeared as a sacrococcygeal teratoma during pregnancy. ( 26013636 )
2015
50
The first description of metyrapone use in severe Cushing Syndrome due to ectopic ACTH secretion in an infant with immature sacrococcygeal teratoma. Case Report. ( 26859587 )
2015

Variations for Sacrococcygeal Teratoma

Expression for Sacrococcygeal Teratoma

Search GEO for disease gene expression data for Sacrococcygeal Teratoma.

Pathways for Sacrococcygeal Teratoma

Pathways related to Sacrococcygeal Teratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.54 AFP CGA

GO Terms for Sacrococcygeal Teratoma

Biological processes related to Sacrococcygeal Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 8.62 CGA CGB7

Molecular functions related to Sacrococcygeal Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 CGA CGB7

Sources for Sacrococcygeal Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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