MCID: SCR036
MIFTS: 16

Sacrum Chordoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Sacrum Chordoma

MalaCards integrated aliases for Sacrum Chordoma:

Name: Sacrum Chordoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050900

Summaries for Sacrum Chordoma

Disease Ontology : 12 A spinal chordoma that is located in the sacrum.

MalaCards based summary : Sacrum Chordoma is related to chordoma and chondrosarcoma. An important gene associated with Sacrum Chordoma is TBXT (T-Box Transcription Factor T). Affiliated tissues include sacrum and myeloid.

Related Diseases for Sacrum Chordoma

Diseases related to Sacrum Chordoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 chordoma 30.3 TBXT MIR608
2 chondrosarcoma 10.0
3 chondroma 10.0
4 chondroid chordoma 10.0
5 clivus chordoma 9.8 HOXA7 HOXA2
6 hand-foot-genital syndrome 9.6 HOXA2 HOXA10
7 leukemia, acute myeloid 9.1 MIR219A1 HOXA7 HOXA10

Graphical network of the top 20 diseases related to Sacrum Chordoma:



Diseases related to Sacrum Chordoma

Symptoms & Phenotypes for Sacrum Chordoma

Drugs & Therapeutics for Sacrum Chordoma

Search Clinical Trials , NIH Clinical Center for Sacrum Chordoma

Genetic Tests for Sacrum Chordoma

Anatomical Context for Sacrum Chordoma

The Foundational Model of Anatomy Ontology organs/tissues related to Sacrum Chordoma:

19
Sacrum

MalaCards organs/tissues related to Sacrum Chordoma:

40
Myeloid

Publications for Sacrum Chordoma

Articles related to Sacrum Chordoma:

# Title Authors PMID Year
1
Computed tomography-guided argon-helium cryoablation for sacrum chordoma. 61
33080695 2020
2
Epidemiologic trend of mobile spine and sacrum chordoma: A National population-based study. 61
33100773 2020
3
Comparison of Wide Margin and Inadequate Margin for Recurrence in Sacral Chordoma: A Meta-Analysis. 61
31977678 2020
4
[Fractionated conformal stereotactic irradiation of recurrent sacral tumour. Case report and first description of the method in Hungary]. 61
24353993 2013
5
Occlusion of the abdominal aorta by balloon dilation catheter assisting surgical excision of a sacrum chordoma: case report. 61
19621292 2009
6
Zoledronic acid in metastatic chondrosarcoma and advanced sacrum chordoma: two case reports. 61
19144109 2009

Variations for Sacrum Chordoma

Expression for Sacrum Chordoma

Search GEO for disease gene expression data for Sacrum Chordoma.

Pathways for Sacrum Chordoma

GO Terms for Sacrum Chordoma

Cellular components related to Sacrum Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 8.92 TBXT HOXA7 HOXA2 HOXA10

Biological processes related to Sacrum Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.71 TBXT HOXA7 HOXA2 HOXA10
2 regulation of transcription, DNA-templated GO:0006355 9.67 TBXT HOXA7 HOXA2 HOXA10
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.61 TBXT HOXA7 HOXA2
4 multicellular organism development GO:0007275 9.46 TBXT HOXA7 HOXA2 HOXA10
5 cellular response to retinoic acid GO:0071300 9.32 TBXT HOXA2
6 embryonic skeletal system morphogenesis GO:0048704 9.26 HOXA7 HOXA2
7 positive regulation of transcription by RNA polymerase II GO:0045944 9.26 TBXT HOXA7 HOXA2 HOXA10
8 anterior/posterior pattern specification GO:0009952 8.92 TBXT HOXA7 HOXA2 HOXA10

Molecular functions related to Sacrum Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.67 TBXT HOXA7 HOXA2 HOXA10
2 DNA-binding transcription factor activity GO:0003700 9.5 TBXT HOXA7 HOXA2
3 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.46 TBXT HOXA7 HOXA2 HOXA10
4 sequence-specific DNA binding GO:0043565 9.43 TBXT HOXA7 HOXA2
5 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.26 TBXT HOXA7 HOXA2 HOXA10
6 sequence-specific double-stranded DNA binding GO:1990837 8.92 TBXT HOXA7 HOXA2 HOXA10

Sources for Sacrum Chordoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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