MCID: SGT001
MIFTS: 36

Sagittal Sinus Thrombosis

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Sagittal Sinus Thrombosis

MalaCards integrated aliases for Sagittal Sinus Thrombosis:

Name: Sagittal Sinus Thrombosis 12 54 44 15 70
Thrombosis of Superior Longitudinal Sinus 12
Thrombosis of Superior Sagittal Sinus 12
Thrombosis Superior Sagittal Sinus 54

Classifications:



External Ids:

Disease Ontology 12 DOID:3576
MeSH 44 D020225
SNOMED-CT 67 70607008
UMLS 70 C0338575

Summaries for Sagittal Sinus Thrombosis

MalaCards based summary : Sagittal Sinus Thrombosis, also known as thrombosis of superior longitudinal sinus, is related to papilledema and intracranial hypertension. An important gene associated with Sagittal Sinus Thrombosis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include myeloid, thyroid and bone marrow, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Sagittal Sinus Thrombosis

Diseases related to Sagittal Sinus Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 322)
# Related Disease Score Top Affiliating Genes
1 papilledema 30.9 SERPINC1 F3 F2
2 intracranial hypertension 30.7 SERPINC1 F5 F3 F2
3 heparin-induced thrombocytopenia 30.6 SERPINC1 F3
4 cerebral sinovenous thrombosis 30.4 F5 F3 F2
5 lateral sinus thrombosis 30.4 SERPINC1 F2
6 intracranial hypotension 30.4 SERPINC1 F3 F2
7 abducens nerve disease 30.4 SERPINC1 F2
8 cortical blindness 30.3 F3 F2
9 hemoglobinuria 30.3 THBD SERPINC1 F2
10 nephrotic syndrome 30.3 SERPINC1 PLG F3 F2
11 paroxysmal nocturnal hemoglobinuria 30.3 THBD SERPINC1 F2
12 protein c deficiency 30.2 THBD SERPINC1 F5 F2
13 cellulitis 30.2 F3 F2
14 cavernous sinus thrombosis 30.1 SERPINC1 F3 F2
15 protein s deficiency 30.1 THBD SERPINC1 F5 F3 F2
16 purpura 30.1 THBD SERPINC1 F3 F2
17 polycythemia 30.0 SERPINC1 JAK2 F5 F2
18 thrombocytosis 29.9 SERPINC1 JAK2 F3 F2
19 antiphospholipid syndrome 29.9 THBD SERPINC1 F5 F3 F2
20 homocystinuria 29.9 THBD SERPINC1 F8 F5
21 moyamoya disease 1 29.6 SERPINC1 PLG F3 F2
22 deficiency anemia 29.5 SERPINC1 PLG JAK2 F5 F2
23 essential thrombocythemia 29.4 THBD SERPINC1 JAK2 F3 F2
24 thrombosis 29.4 THBD SERPINC1 PLG JAK2 F8 F5
25 antithrombin iii deficiency 29.4 SERPINC1 PLG JAK2 F5 F2
26 budd-chiari syndrome 29.4 SERPINC1 JAK2 F5 F3 F2
27 disseminated intravascular coagulation 29.3 THBD SERPINC1 PLG F5 F3 F2
28 pulmonary embolism 29.2 THBD SERPINC1 F8 F5 F3 F2
29 intracranial thrombosis 29.1 SERPINC1 PLG F8 F5 F3 F2
30 thrombophlebitis 28.6 SERPINC1 PLG F8 F5 F3 F2
31 thrombophilia 28.6 THBD SERPINC1 JAK2 F8 F5 F3
32 intracranial sinus thrombosis 28.6 SERPINC1 PLG MICU2 F8 F3 F2
33 thrombocytopenia 28.2 THBD SERPINC1 PLG JAK2 F8 F5
34 headache 10.5
35 head injury 10.4
36 ocular motor apraxia 10.4
37 leukemia, acute lymphoblastic 10.4
38 intracranial hypertension, idiopathic 10.3
39 hemiplegia 10.3
40 ulcerative colitis 10.3
41 colitis 10.3
42 hydrocephalus 10.3
43 status epilepticus 10.3
44 brain edema 10.3
45 vulvar angiokeratoma 10.3 SERPINC1 F3
46 achenbach syndrome 10.3 F3 F2
47 renal pelvis squamous cell carcinoma 10.2 F3 F2
48 papillary adenofibroma 10.2 F3 F2
49 femoral neuropathy 10.2 F3 F2
50 emphysematous cholecystitis 10.2 F3 F2

Graphical network of the top 20 diseases related to Sagittal Sinus Thrombosis:



Diseases related to Sagittal Sinus Thrombosis

Symptoms & Phenotypes for Sagittal Sinus Thrombosis

MGI Mouse Phenotypes related to Sagittal Sinus Thrombosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.08 F2 F3 F5 JAK2 MICU2 PLG
2 homeostasis/metabolism MP:0005376 10.06 F2 F3 F5 F8 JAK2 MICU2
3 cellular MP:0005384 10 F2 F3 JAK2 MICU2 PLG SERPINC1
4 embryo MP:0005380 9.91 F2 F3 F5 JAK2 SERPINC1 THBD
5 immune system MP:0005387 9.91 F2 F3 F8 JAK2 PLG SERPINC1
6 mortality/aging MP:0010768 9.81 F2 F3 F5 F8 JAK2 MICU2
7 integument MP:0010771 9.8 F2 F3 F5 JAK2 PLG THBD
8 liver/biliary system MP:0005370 9.65 F5 JAK2 PLG SERPINC1 THBD
9 reproductive system MP:0005389 9.43 F2 F8 JAK2 PLG SERPINC1 THBD
10 respiratory system MP:0005388 9.02 F2 F3 JAK2 PLG THBD

Drugs & Therapeutics for Sagittal Sinus Thrombosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of the Radiological Pattern Between the Cerebral Stroke of Arterial and Venous Origin Completed NCT03611894

Search NIH Clinical Center for Sagittal Sinus Thrombosis

Cochrane evidence based reviews: sagittal sinus thrombosis

Genetic Tests for Sagittal Sinus Thrombosis

Anatomical Context for Sagittal Sinus Thrombosis

MalaCards organs/tissues related to Sagittal Sinus Thrombosis:

40
Myeloid, Thyroid, Bone Marrow, Endothelial

Publications for Sagittal Sinus Thrombosis

Articles related to Sagittal Sinus Thrombosis:

(show top 50) (show all 449)
# Title Authors PMID Year
1
Sagittal sinus thrombosis in a teenager: homocystinuria associated with reversible antithrombin deficiency. 61 54
12162390 2002
2
Superior sagittal sinus thrombosis with homocystinuria and deficiency of antithrombin III and factor VII: case report. 54 61
10399003 1998
3
Activated protein C resistance (factor V Leiden) associated with thrombosis in pregnancy. 61 54
9125617 1997
4
Multicentric reticulohistiocytosis: an association with chronic sagittal sinus thrombosis. 61
32875639 2021
5
[CT and MRI Findings of Cortical Venous Thrombosis and Cerebral Venous Sinus Thrombosis]. 61
33762445 2021
6
A Rare Presentation of Neurobrucellosis in a 6-Year-Old Pediatric Patient with Sagittal Sinus Thrombosis. 61
33017853 2021
7
Combined venous and arterial thrombosis revealing underlying myeloproliferative disorder in a young patient: a case report. 61
33593422 2021
8
Acute symptomatic seizures in cerebral venous thrombosis. 61
32759191 2020
9
Acute Seizures in Cerebral Venous Sinus Thrombosis: Risk Factors and Prognosis. 61
32925483 2020
10
Superior sagittal sinus thrombosis after spinal anesthesia. 61
32683402 2020
11
Case report: postpartum cerebral venous thrombosis misdiagnosed as postdural puncture headache. 61
32264827 2020
12
A Rare Case of Cryptococcus gattii Meningitis in Advanced HIV Disease, Sagittal Thrombosis, and Immune Reconstitution Syndrome, Resolved With Isavuconazonium. 61
32935587 2020
13
Hyperthyroidism as a Precipitant Factor for Cerebral Venous Thrombosis: A Case Report. 61
32787455 2020
14
Intraparenchymal hemorrhage and cerebral venous thrombosis in an adult with congenital porencephalic cyst presenting for generalized tonic-clonic seizures. 61
31762865 2020
15
Successful treatment of superior sagittal sinus thrombosis after translabyrinthine resection of metastatic neuroendocrine tumor: A case report and review of literature. 61
33365173 2020
16
Clinical Characteristics of Behcet's Disease in 453 Egyptian Patients Suffering from Uveitis with Gender Comparison. 61
31804160 2020
17
Behçet's disease; A rare refractory patient with vena cava superior syndrome treated with infliximab: a case report and review of the literature. 61
30220250 2019
18
Ophthalmic artery occlusion combined with superior sagittal sinus thrombosis caused by hyaluronic acid injection for facial soft tissue augmentation: A case report. 61
31490398 2019
19
Superior Sagittal Venous Sinus Thrombosis in a Patient with Illicit Testosterone Use. 61
31489277 2019
20
Superior sagittal sinus thrombosis secondary to Tamoxifen treatment. 61
30972841 2019
21
Endovascular mechanical thrombectomy for superior sagittal sinus thrombosis in a patient with T-lymphoblastic lymphoma treated with L-asparaginase. 61
31092500 2019
22
Superior sagittal sinus thrombosis as a rare complication of spontaneous intracranial hypotension syndrome: a case report and review of the literature. 61
30345841 2019
23
Longitudinal Volume Quantification of Deep Medullary Veins in Patients with Cerebral Venous Sinus Thrombosis : Venous Volume Assessment in Cerebral Venous Sinus Thrombosis Using SWI. 61
28589484 2018
24
Postpartum Superior Sagittal Sinus Thrombosis: A Case Report. 61
30402435 2018
25
A non-hydrocephalic goat experimental model to evaluate a ventriculosinus shunt. 61
29458296 2018
26
Cases of visual impairment caused by cerebral venous sinus occlusion-induced intracranial hypertension in the absence of headache. 61
30268100 2018
27
Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery. 61
29987845 2018
28
Superior sagittal sinus thrombosis in a case of Mixed Connective Tissue Disease. 61
29848537 2018
29
Herpes simplex virus (HSV) encephalitis in a young man: an unusual course. 61
29478004 2018
30
A rabbit model of cerebral venous sinus thrombosis established by ferric chloride and thrombin injection. 61
29061392 2018
31
Thromboembolic events in patients with advanced stage non-small cell lung cancer treated with platinum-based chemotherapy: a prospective observational study. 61
30483356 2018
32
Clinical features of seizures after cerebral venous sinus thrombosis and its effect on outcome among Chinese Han population. 61
29507778 2017
33
Serial Arterial Spin Labeling May Be Useful in Assessing the Therapeutic Course of Cerebral Venous Thrombosis: Case Reports. 61
28835576 2017
34
RUNX1-RUNX1T1-positive acute myeloid leukaemia presenting as bilateral proptosis and multiple cranial nerve palsy. 61
28993357 2017
35
Superior sagittal sinus thrombosis in a patient with acute lymphoblastic leukemia. 61
28038855 2017
36
Congenital dysfibrinogenemia in a Japanese family with fibrinogen Naples (BĪ²Ala68Thr) manifesting as superior sagittal sinus thrombosis. 61
28537987 2017
37
Pharmacological management of cerebral venous sinus thrombosis with full-dose IV heparin infusion and its clinical outcomes. 61
28434771 2017
38
Sagittal sinus thrombosis in JAK2-V617F mutation without overt myeloproliferative disorder. 61
28228434 2017
39
A rare complication of pulmonary tuberculosis - Pulmonary venous thrombosis with atrial extension. 61
28451090 2017
40
Multiple Dural and Pial Arteriovenous Fistulae in a Twenty-Four-Year-Old Woman in the Setting of Superior Sagittal Sinus Thrombosis: Case Report and Review of Literature. 61
27544867 2016
41
Treatment of the Superior Sagittal Sinus Thrombosis with the Mechanical Thrombectomy Using Stent-Retriever Device. 61
27651872 2016
42
Reliable low-molecular-weight heparin reversal in a child undergoing emergency surgery: a case report. 61
27555185 2016
43
Superior Sagittal Sinus Thrombosis Related to the Use of Tamoxifen: A Case Report and Review of Literature. 61
29782786 2016
44
Dural Arteriovenous Fistula Could Be Due to Hemodynamic Disturbance in Dural Physiological Shunts? Histopathological Study and a Case Report. 61
26899466 2016
45
[Superior sagittal sinus thrombosis after intrathecal chemotherapy and intravenous high-dose cytarabine in an acute myeloid leukemia case with t(8;21)(q22;q22)]. 61
27169454 2016
46
Time to recanalisation in patients with cerebral venous thrombosis under anticoagulation therapy. 61
25802120 2016
47
Pediatric Cortical Vein Thrombosis: Frequency and Association With Venous Infarction. 61
26888536 2016
48
Erythrocytosis due to PHD2 Mutations: A Review of Clinical Presentation, Diagnosis, and Genetics. 61
27034858 2016
49
Papilledema secondary to a superior sagittal sinus thrombosis. Mantle cell lymphoma paraneoplastic syndrome. 61
26596713 2016
50
[Progressive Intracranial Hypertension due to Superior Sagittal Sinus Thrombosis Following Mild Head Trauma: A Case Report]. 61
26136327 2015

Variations for Sagittal Sinus Thrombosis

Expression for Sagittal Sinus Thrombosis

Search GEO for disease gene expression data for Sagittal Sinus Thrombosis.

Pathways for Sagittal Sinus Thrombosis

GO Terms for Sagittal Sinus Thrombosis

Cellular components related to Sagittal Sinus Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.97 THBD SERPINC1 PLG JAK2 F8 F5
2 extracellular region GO:0005576 9.88 SERPINC1 PLG F8 F5 F3 F2
3 collagen-containing extracellular matrix GO:0062023 9.56 SERPINC1 PLG F3 F2
4 blood microparticle GO:0072562 9.5 SERPINC1 PLG F2
5 endoplasmic reticulum lumen GO:0005788 9.46 SERPINC1 F8 F5 F2
6 COPII-coated ER to Golgi transport vesicle GO:0030134 9.43 F8 F5
7 extracellular space GO:0005615 9.17 THBD SERPINC1 PLG F8 F5 F3
8 platelet alpha granule lumen GO:0031093 9.13 PLG F8 F5

Biological processes related to Sagittal Sinus Thrombosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 ER to Golgi vesicle-mediated transport GO:0006888 9.65 F8 F5 F2
2 cellular protein metabolic process GO:0044267 9.56 SERPINC1 PLG F5 F2
3 blood coagulation GO:0007596 9.56 THBD SERPINC1 PLG JAK2 F8 F5
4 platelet degranulation GO:0002576 9.54 PLG F8 F5
5 acute-phase response GO:0006953 9.49 F8 F2
6 fibrinolysis GO:0042730 9.46 PLG F2
7 blood coagulation, intrinsic pathway GO:0007597 9.43 F8 F2
8 regulation of blood coagulation GO:0030193 9.4 SERPINC1 F2
9 negative regulation of fibrinolysis GO:0051918 9.33 THBD PLG F2
10 negative regulation of platelet activation GO:0010544 9.32 THBD F2
11 hemostasis GO:0007599 9.17 THBD SERPINC1 PLG F8 F5 F3

Molecular functions related to Sagittal Sinus Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 PLG F3 F2

Sources for Sagittal Sinus Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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