MCID: SGT001
MIFTS: 32

Sagittal Sinus Thrombosis

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Sagittal Sinus Thrombosis

MalaCards integrated aliases for Sagittal Sinus Thrombosis:

Name: Sagittal Sinus Thrombosis 12 54 43 15 71
Thrombosis of Superior Longitudinal Sinus 12
Thrombosis of Superior Sagittal Sinus 12
Thrombosis Superior Sagittal Sinus 54

Classifications:



External Ids:

Disease Ontology 12 DOID:3576
MeSH 43 D020225
SNOMED-CT 67 70607008
UMLS 71 C0338575

Summaries for Sagittal Sinus Thrombosis

MalaCards based summary : Sagittal Sinus Thrombosis, also known as thrombosis of superior longitudinal sinus, is related to papilledema and intracranial hypertension, idiopathic. An important gene associated with Sagittal Sinus Thrombosis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include brain, myeloid and bone.

Related Diseases for Sagittal Sinus Thrombosis

Diseases related to Sagittal Sinus Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 283)
# Related Disease Score Top Affiliating Genes
1 papilledema 30.9 SERPINC1 F3 F2
2 intracranial hypertension, idiopathic 30.9 F3 F2
3 thrombophilia due to thrombin defect 30.9 SERPINC1 F5 F3 F2
4 thrombosis 30.8 SERPINC1 PLG F5 F3 F2
5 heparin-induced thrombocytopenia 30.7 SERPINC1 F3
6 intracranial hypotension 30.6 F3 F2
7 intracranial hypertension 30.6 SERPINC1 F5 F3 F2
8 protein c deficiency 30.5 SERPINC1 F5 F2
9 cavernous sinus thrombosis 30.4 SERPINC1 F2
10 cortical blindness 30.4 F3 F2
11 cerebral sinovenous thrombosis 30.4 F5 F3 F2
12 purpura 30.4 SERPINC1 F3 F2
13 protein s deficiency 30.4 SERPINC1 F5 F3 F2
14 thrombocytosis 30.3 SERPINC1 F3 F2
15 pulmonary embolism 30.2 SERPINC1 F5 F3 F2
16 antiphospholipid syndrome 30.1 SERPINC1 F5 F3 F2
17 thrombocytopenia 30.1 SERPINC1 F5 F3 F2
18 essential thrombocythemia 30.0 SERPINC1 F3 F2
19 lateral sinus thrombosis 29.8 ZNF398 SERPINC1 F2
20 ovarian hyperstimulation syndrome 29.8 SERPINC1 F5
21 antithrombin iii deficiency 29.7 SERPINC1 PLG F5 F2
22 budd-chiari syndrome 29.7 SERPINC1 F5 F3 F2
23 intracranial thrombosis 29.6 SERPINC1 PLG F5 F3 F2
24 moyamoya disease 1 29.5 SERPINC1 PLG F3 F2
25 disseminated intravascular coagulation 29.4 SERPINC1 PLG F5 F3 F2
26 thrombophilia 29.3 SERPINC1 PLG F5 F3 F2
27 thrombophlebitis 29.1 SERPINC1 PLG F5 F3 F2
28 stroke, ischemic 28.8 TSPAN33 SERPINC1 PLG F5 F3 F2
29 intracranial sinus thrombosis 28.3 ZNF398 TSPAN33 SERPINC1 PLG F3 F2
30 headache 10.6
31 ocular motor apraxia 10.5
32 nephrotic syndrome 10.5
33 head injury 10.4
34 leukemia, acute lymphoblastic 10.4
35 lymphocytic leukemia 10.4
36 vulvar angiokeratoma 10.4 SERPINC1 F3
37 gastric hemangioma 10.3 F3 F2
38 deficiency anemia 10.3
39 colitis 10.3
40 hemiplegia 10.3
41 ulcerative colitis 10.3
42 homocystinuria 10.3
43 waterhouse-friderichsen syndrome 10.3 SERPINC1 F2
44 synovial angioma 10.3 F3 F2
45 renal pelvis squamous cell carcinoma 10.3 F3 F2
46 papillary adenofibroma 10.3 F3 F2
47 emphysematous cholecystitis 10.3 F3 F2
48 femoral neuropathy 10.3 F3 F2
49 sticky platelet syndrome 10.3 SERPINC1 F5
50 thrombophlebitis migrans 10.3 SERPINC1 F3

Graphical network of the top 20 diseases related to Sagittal Sinus Thrombosis:



Diseases related to Sagittal Sinus Thrombosis

Symptoms & Phenotypes for Sagittal Sinus Thrombosis

Drugs & Therapeutics for Sagittal Sinus Thrombosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of the Radiological Pattern Between the Cerebral Stroke of Arterial and Venous Origin Completed NCT03611894

Search NIH Clinical Center for Sagittal Sinus Thrombosis

Cochrane evidence based reviews: sagittal sinus thrombosis

Genetic Tests for Sagittal Sinus Thrombosis

Anatomical Context for Sagittal Sinus Thrombosis

MalaCards organs/tissues related to Sagittal Sinus Thrombosis:

40
Brain, Myeloid, Bone, B Cells, Heart, Thyroid, T Cells

Publications for Sagittal Sinus Thrombosis

Articles related to Sagittal Sinus Thrombosis:

(show top 50) (show all 438)
# Title Authors PMID Year
1
Sagittal sinus thrombosis in a teenager: homocystinuria associated with reversible antithrombin deficiency. 54 61
12162390 2002
2
Superior sagittal sinus thrombosis with homocystinuria and deficiency of antithrombin III and factor VII: case report. 54 61
10399003 1998
3
Activated protein C resistance (factor V Leiden) associated with thrombosis in pregnancy. 54 61
9125617 1997
4
Intraparenchymal hemorrhage and cerebral venous thrombosis in an adult with congenital porencephalic cyst presenting for generalized tonic-clonic seizures. 61
31762865 2020
5
Behçet's disease; A rare refractory patient with vena cava superior syndrome treated with infliximab: a case report and review of the literature. 61
30220250 2019
6
Clinical characteristics of Behcet's disease in 453 Egyptian patients suffering from uveitis with gender comparison. 61
31804160 2019
7
Ophthalmic artery occlusion combined with superior sagittal sinus thrombosis caused by hyaluronic acid injection for facial soft tissue augmentation: A case report. 61
31490398 2019
8
Superior Sagittal Venous Sinus Thrombosis in a Patient with Illicit Testosterone Use. 61
31489277 2019
9
Superior sagittal sinus thrombosis secondary to Tamoxifen treatment. 61
30972841 2019
10
Endovascular mechanical thrombectomy for superior sagittal sinus thrombosis in a patient with T-lymphoblastic lymphoma treated with L-asparaginase. 61
31092500 2019
11
Superior sagittal sinus thrombosis as a rare complication of spontaneous intracranial hypotension syndrome: a case report and review of the literature. 61
30345841 2019
12
Longitudinal Volume Quantification of Deep Medullary Veins in Patients with Cerebral Venous Sinus Thrombosis : Venous Volume Assessment in Cerebral Venous Sinus Thrombosis Using SWI. 61
28589484 2018
13
Postpartum Superior Sagittal Sinus Thrombosis: A Case Report. 61
30402435 2018
14
A non-hydrocephalic goat experimental model to evaluate a ventriculosinus shunt. 61
29458296 2018
15
Cases of visual impairment caused by cerebral venous sinus occlusion-induced intracranial hypertension in the absence of headache. 61
30268100 2018
16
Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery. 61
29987845 2018
17
Superior sagittal sinus thrombosis in a case of Mixed Connective Tissue Disease. 61
29848537 2018
18
Herpes simplex virus (HSV) encephalitis in a young man: an unusual course. 61
29478004 2018
19
A rabbit model of cerebral venous sinus thrombosis established by ferric chloride and thrombin injection. 61
29061392 2018
20
Thromboembolic events in patients with advanced stage non-small cell lung cancer treated with platinum-based chemotherapy: a prospective observational study. 61
30483356 2018
21
Clinical features of seizures after cerebral venous sinus thrombosis and its effect on outcome among Chinese Han population. 61
29507778 2017
22
Serial Arterial Spin Labeling May Be Useful in Assessing the Therapeutic Course of Cerebral Venous Thrombosis: Case Reports. 61
28835576 2017
23
Superior sagittal sinus thrombosis in a patient with acute lymphoblastic leukemia. 61
28038855 2017
24
Congenital dysfibrinogenemia in a Japanese family with fibrinogen Naples (BĪ²Ala68Thr) manifesting as superior sagittal sinus thrombosis. 61
28537987 2017
25
RUNX1-RUNX1T1-positive acute myeloid leukaemia presenting as bilateral proptosis and multiple cranial nerve palsy. 61
28993357 2017
26
Pharmacological management of cerebral venous sinus thrombosis with full-dose IV heparin infusion and its clinical outcomes. 61
28434771 2017
27
Sagittal sinus thrombosis in JAK2-V617F mutation without overt myeloproliferative disorder. 61
28228434 2017
28
A rare complication of pulmonary tuberculosis - Pulmonary venous thrombosis with atrial extension. 61
28451090 2017
29
Multiple Dural and Pial Arteriovenous Fistulae in a Twenty-Four-Year-Old Woman in the Setting of Superior Sagittal Sinus Thrombosis: Case Report and Review of Literature. 61
27544867 2016
30
Reliable low-molecular-weight heparin reversal in a child undergoing emergency surgery: a case report. 61
27555185 2016
31
Superior Sagittal Sinus Thrombosis Related to the Use of Tamoxifen: A Case Report and Review of Literature. 61
29782786 2016
32
Treatment of the Superior Sagittal Sinus Thrombosis with the Mechanical Thrombectomy Using Stent-Retriever Device. 61
27651872 2016
33
Dural Arteriovenous Fistula Could Be Due to Hemodynamic Disturbance in Dural Physiological Shunts? Histopathological Study and a Case Report. 61
26899466 2016
34
[Superior sagittal sinus thrombosis after intrathecal chemotherapy and intravenous high-dose cytarabine in an acute myeloid leukemia case with t(8;21)(q22;q22)]. 61
27169454 2016
35
Time to recanalisation in patients with cerebral venous thrombosis under anticoagulation therapy. 61
25802120 2016
36
Pediatric Cortical Vein Thrombosis: Frequency and Association With Venous Infarction. 61
26888536 2016
37
Erythrocytosis due to PHD2 Mutations: A Review of Clinical Presentation, Diagnosis, and Genetics. 61
27034858 2016
38
Papilledema secondary to a superior sagittal sinus thrombosis. Mantle cell lymphoma paraneoplastic syndrome. 61
26596713 2016
39
Sagittal sinus thrombosis in puerperium. 61
26229306 2015
40
[Progressive Intracranial Hypertension due to Superior Sagittal Sinus Thrombosis Following Mild Head Trauma: A Case Report]. 61
26136327 2015
41
Neck Pain One Week after Pacemaker Generator Replacement. 61
25910823 2015
42
Superior sagittal sinus thrombosis as the initial presentation of renal cell carcinoma. 61
25829662 2015
43
Neurological recovery after coma related to diffuse cerebral venous sinus thrombosis. Interest in thrombi-aspiration with Penumbra system. 61
25943847 2015
44
Antegrade rheolytic thrombectomy and thrombolysis for superior sagittal sinus thrombosis using burr hole access. 61
24699566 2015
45
Postdural Puncture Superior Sagittal Sinus Thrombosis in a Juvenile Case of Clinically Isolated Syndrome. 61
26558127 2015
46
A Very Rare Cerebral Complication of Chemotherapy in a Young Girl: A Difficult Diagnosis. 61
25981579 2015
47
Venous sinus thrombosis secondary to tuberculous meningitis: a novel cause of trigeminal neuralgia. 61
25422343 2014
48
A new thrombosis model of the superior sagittal sinus involving cortical veins. 61
23182733 2014
49
Cerebral venous thrombosis as a rare cause of subarachnoid hemorrhage: case report and literature review. 61
24746346 2014
50
Clinical profile and outcome of cerebral venous sinus thrombosis at tertiary care center. 61
25002759 2014

Variations for Sagittal Sinus Thrombosis

Expression for Sagittal Sinus Thrombosis

Search GEO for disease gene expression data for Sagittal Sinus Thrombosis.

Pathways for Sagittal Sinus Thrombosis

GO Terms for Sagittal Sinus Thrombosis

Cellular components related to Sagittal Sinus Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.33 SERPINC1 PLG F2
2 collagen-containing extracellular matrix GO:0062023 9.26 SERPINC1 PLG F3 F2
3 endoplasmic reticulum lumen GO:0005788 8.92 TSPAN33 SERPINC1 F5 F2

Biological processes related to Sagittal Sinus Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.55 TSPAN33 SERPINC1 PLG F5 F2
2 fibrinolysis GO:0042730 9.37 PLG F2
3 blood coagulation GO:0007596 9.35 SERPINC1 PLG F5 F3 F2
4 regulation of blood coagulation GO:0030193 9.32 SERPINC1 F2
5 negative regulation of fibrinolysis GO:0051918 9.26 PLG F2
6 hemostasis GO:0007599 9.02 SERPINC1 PLG F5 F3 F2

Molecular functions related to Sagittal Sinus Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 PLG F3 F2

Sources for Sagittal Sinus Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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