MCID: SGT001
MIFTS: 33

Sagittal Sinus Thrombosis

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Sagittal Sinus Thrombosis

MalaCards integrated aliases for Sagittal Sinus Thrombosis:

Name: Sagittal Sinus Thrombosis 12 55 44 15 72
Thrombosis of Superior Longitudinal Sinus 12
Thrombosis of Superior Sagittal Sinus 12
Thrombosis Superior Sagittal Sinus 55

Classifications:



External Ids:

Disease Ontology 12 DOID:3576
MeSH 44 D020225
SNOMED-CT 68 70607008
UMLS 72 C0338575

Summaries for Sagittal Sinus Thrombosis

MalaCards based summary : Sagittal Sinus Thrombosis, also known as thrombosis of superior longitudinal sinus, is related to heparin-induced thrombocytopenia and intracranial sinus thrombosis. An important gene associated with Sagittal Sinus Thrombosis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include brain, myeloid and thyroid, and related phenotypes are embryo and homeostasis/metabolism

Related Diseases for Sagittal Sinus Thrombosis

Diseases related to Sagittal Sinus Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 247)
# Related Disease Score Top Affiliating Genes
1 heparin-induced thrombocytopenia 30.5 SERPINC1 F3
2 intracranial sinus thrombosis 30.3 SERPINC1 BLVRA
3 thrombosis 30.1 SERPINC1 F5 F3 F2
4 homocystinuria 29.9 SERPINC1 F5
5 intracranial thrombosis 29.8 SERPINC1 F5 F3
6 purpura 29.8 SERPINC1 F3 F2
7 thrombocytosis 29.7 SERPINC1 F3 F2
8 thrombophilia due to thrombin defect 29.6 SERPINC1 F5 F3 F2
9 protein c deficiency 29.5 SERPINC1 F5 F2
10 cerebral sinovenous thrombosis 29.4 F5 F3 F2
11 intracranial hypertension 29.3 SERPINC1 F5 F3 F2
12 antithrombin iii deficiency 29.3 SERPINC1 F5 F2
13 thrombophlebitis 29.1 SERPINC1 F5 F2
14 cerebrovascular disease 29.1 F5 F2
15 dysfibrinogenemia 29.1 SERPINC1 F5 F2
16 protein s deficiency 29.1 SERPINC1 F5 F3 F2
17 pulmonary embolism 28.9 SERPINC1 F5 F3 F2
18 antiphospholipid syndrome 28.9 SERPINC1 F5 F3 F2
19 disseminated intravascular coagulation 28.8 SERPINC1 F5 F3 F2
20 thrombophilia 28.6 SERPINC1 F5 F3 F2
21 stroke, ischemic 28.6 SERPINC1 F5 F3 F2
22 budd-chiari syndrome 28.4 SERPINC1 F5 F3 F2
23 headache 10.6
24 papilledema 10.5
25 ocular motor apraxia 10.5
26 nephrotic syndrome 10.5
27 head injury 10.4
28 leukemia, acute lymphoblastic 10.4
29 lymphocytic leukemia 10.4
30 intracranial hypertension, idiopathic 10.3
31 deficiency anemia 10.3
32 colitis 10.3
33 hemiplegia 10.3
34 ulcerative colitis 10.3
35 systemic lupus erythematosus 10.3
36 hydrocephalus 10.3
37 thrombocytopenia 10.3
38 status epilepticus 10.3
39 brain edema 10.3
40 congenital hydrocephalus 10.3
41 graves disease 1 10.2
42 aphasia 10.2
43 lymphoblastic lymphoma 10.2
44 graves' disease 10.2
45 polycythemia 10.2
46 vasculitis 10.2
47 lupus erythematosus 10.2
48 endocarditis 10.2 SERPINC1 F2
49 eclampsia 10.2 SERPINC1 F2
50 intermediate coronary syndrome 10.2 SERPINC1 F3

Graphical network of the top 20 diseases related to Sagittal Sinus Thrombosis:



Diseases related to Sagittal Sinus Thrombosis

Symptoms & Phenotypes for Sagittal Sinus Thrombosis

MGI Mouse Phenotypes related to Sagittal Sinus Thrombosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.26 F2 F3 F5 SERPINC1
2 homeostasis/metabolism MP:0005376 9.02 BLVRA F2 F3 F5 SERPINC1

Drugs & Therapeutics for Sagittal Sinus Thrombosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of the Radiological Pattern Between the Cerebral Stroke of Arterial and Venous Origin Completed NCT03611894

Search NIH Clinical Center for Sagittal Sinus Thrombosis

Cochrane evidence based reviews: sagittal sinus thrombosis

Genetic Tests for Sagittal Sinus Thrombosis

Anatomical Context for Sagittal Sinus Thrombosis

MalaCards organs/tissues related to Sagittal Sinus Thrombosis:

41
Brain, Myeloid, Thyroid, T Cells, Lung, Bone, Bone Marrow

Publications for Sagittal Sinus Thrombosis

Articles related to Sagittal Sinus Thrombosis:

(show top 50) (show all 434)
# Title Authors PMID Year
1
Sagittal sinus thrombosis in a teenager: homocystinuria associated with reversible antithrombin deficiency. 9 38
12162390 2002
2
Superior sagittal sinus thrombosis with homocystinuria and deficiency of antithrombin III and factor VII: case report. 9 38
10399003 1998
3
Activated protein C resistance (factor V Leiden) associated with thrombosis in pregnancy. 9 38
9125617 1997
4
Behçet's disease; A rare refractory patient with vena cava superior syndrome treated with infliximab: a case report and review of the literature. 38
30220250 2019
5
Superior sagittal sinus thrombosis secondary to Tamoxifen treatment. 38
30972841 2019
6
Endovascular mechanical thrombectomy for superior sagittal sinus thrombosis in a patient with T-lymphoblastic lymphoma treated with L-asparaginase. 38
31092500 2019
7
Superior sagittal sinus thrombosis as a rare complication of spontaneous intracranial hypotension syndrome: a case report and review of the literature. 38
30345841 2019
8
Longitudinal Volume Quantification of Deep Medullary Veins in Patients with Cerebral Venous Sinus Thrombosis : Venous Volume Assessment in Cerebral Venous Sinus Thrombosis Using SWI. 38
28589484 2018
9
Postpartum Superior Sagittal Sinus Thrombosis: A Case Report. 38
30402435 2018
10
A non-hydrocephalic goat experimental model to evaluate a ventriculosinus shunt. 38
29458296 2018
11
Cases of visual impairment caused by cerebral venous sinus occlusion-induced intracranial hypertension in the absence of headache. 38
30268100 2018
12
Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery. 38
29987845 2018
13
Superior sagittal sinus thrombosis in a case of Mixed Connective Tissue Disease. 38
29848537 2018
14
Herpes simplex virus (HSV) encephalitis in a young man: an unusual course. 38
29478004 2018
15
A rabbit model of cerebral venous sinus thrombosis established by ferric chloride and thrombin injection. 38
29061392 2018
16
Thromboembolic events in patients with advanced stage non-small cell lung cancer treated with platinum-based chemotherapy: a prospective observational study. 38
30483356 2018
17
Clinical features of seizures after cerebral venous sinus thrombosis and its effect on outcome among Chinese Han population. 38
29507778 2017
18
Superior sagittal sinus thrombosis in a patient with acute lymphoblastic leukemia. 38
28038855 2017
19
Serial Arterial Spin Labeling May Be Useful in Assessing the Therapeutic Course of Cerebral Venous Thrombosis: Case Reports. 38
28835576 2017
20
Congenital dysfibrinogenemia in a Japanese family with fibrinogen Naples (BĪ²Ala68Thr) manifesting as superior sagittal sinus thrombosis. 38
28537987 2017
21
RUNX1-RUNX1T1-positive acute myeloid leukaemia presenting as bilateral proptosis and multiple cranial nerve palsy. 38
28993357 2017
22
Pharmacological management of cerebral venous sinus thrombosis with full-dose IV heparin infusion and its clinical outcomes. 38
28434771 2017
23
Sagittal sinus thrombosis in JAK2-V617F mutation without overt myeloproliferative disorder. 38
28228434 2017
24
A rare complication of pulmonary tuberculosis - Pulmonary venous thrombosis with atrial extension. 38
28451090 2017
25
Multiple Dural and Pial Arteriovenous Fistulae in a Twenty-Four-Year-Old Woman in the Setting of Superior Sagittal Sinus Thrombosis: Case Report and Review of Literature. 38
27544867 2016
26
Treatment of the Superior Sagittal Sinus Thrombosis with the Mechanical Thrombectomy Using Stent-Retriever Device. 38
27651872 2016
27
Reliable low-molecular-weight heparin reversal in a child undergoing emergency surgery: a case report. 38
27555185 2016
28
Superior Sagittal Sinus Thrombosis Related to the Use of Tamoxifen: A Case Report and Review of Literature. 38
29782786 2016
29
Dural Arteriovenous Fistula Could Be Due to Hemodynamic Disturbance in Dural Physiological Shunts? Histopathological Study and a Case Report. 38
26899466 2016
30
[Superior sagittal sinus thrombosis after intrathecal chemotherapy and intravenous high-dose cytarabine in an acute myeloid leukemia case with t(8;21)(q22;q22)]. 38
27169454 2016
31
Time to recanalisation in patients with cerebral venous thrombosis under anticoagulation therapy. 38
25802120 2016
32
Pediatric Cortical Vein Thrombosis: Frequency and Association With Venous Infarction. 38
26888536 2016
33
Erythrocytosis due to PHD2 Mutations: A Review of Clinical Presentation, Diagnosis, and Genetics. 38
27034858 2016
34
Papilledema secondary to a superior sagittal sinus thrombosis. Mantle cell lymphoma paraneoplastic syndrome. 38
26596713 2016
35
Sagittal sinus thrombosis in puerperium. 38
26229306 2015
36
Neck Pain One Week after Pacemaker Generator Replacement. 38
25910823 2015
37
[Progressive Intracranial Hypertension due to Superior Sagittal Sinus Thrombosis Following Mild Head Trauma: A Case Report]. 38
26136327 2015
38
Superior sagittal sinus thrombosis as the initial presentation of renal cell carcinoma. 38
25829662 2015
39
Neurological recovery after coma related to diffuse cerebral venous sinus thrombosis. Interest in thrombi-aspiration with Penumbra system. 38
25943847 2015
40
Antegrade rheolytic thrombectomy and thrombolysis for superior sagittal sinus thrombosis using burr hole access. 38
24699566 2015
41
A Very Rare Cerebral Complication of Chemotherapy in a Young Girl: A Difficult Diagnosis. 38
25981579 2015
42
Postdural Puncture Superior Sagittal Sinus Thrombosis in a Juvenile Case of Clinically Isolated Syndrome. 38
26558127 2015
43
Venous sinus thrombosis secondary to tuberculous meningitis: a novel cause of trigeminal neuralgia. 38
25422343 2014
44
A new thrombosis model of the superior sagittal sinus involving cortical veins. 38
23182733 2014
45
Cerebral venous thrombosis as a rare cause of subarachnoid hemorrhage: case report and literature review. 38
24746346 2014
46
Clinical profile and outcome of cerebral venous sinus thrombosis at tertiary care center. 38
25002759 2014
47
Cerebral vein thrombosis in a four year old with Behçet's disease. 38
24388639 2014
48
Comparison of anticoagulation and thrombolysis treatments in a rat model of superior sagittal sinus thrombosis. 38
24195615 2014
49
Successful treatment of extensive cerebral venous sinus thrombosis using a combined approach with Penumbra aspiration system and Solitaire FR retrieval device. 38
24049112 2014
50
Antegrade rheolytic thrombectomy and thrombolysis for superior sagittal sinus thrombosis using burr hole access. 38
24692369 2014

Variations for Sagittal Sinus Thrombosis

Expression for Sagittal Sinus Thrombosis

Search GEO for disease gene expression data for Sagittal Sinus Thrombosis.

Pathways for Sagittal Sinus Thrombosis

GO Terms for Sagittal Sinus Thrombosis

Cellular components related to Sagittal Sinus Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 SERPINC1 F5 F3 F2
2 endoplasmic reticulum lumen GO:0005788 8.8 SERPINC1 F5 F2

Biological processes related to Sagittal Sinus Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.43 SERPINC1 F5 F2
2 blood coagulation GO:0007596 9.26 SERPINC1 F5 F3 F2
3 regulation of blood coagulation GO:0030193 9.16 SERPINC1 F2
4 hemostasis GO:0007599 8.92 SERPINC1 F5 F3 F2

Molecular functions related to Sagittal Sinus Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.62 SERPINC1 F3

Sources for Sagittal Sinus Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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