MCID: SLV003
MIFTS: 41

Salivary Gland Disease

Categories: Endocrine diseases, Gastrointestinal diseases, Immune diseases, Oral diseases

Aliases & Classifications for Salivary Gland Disease

MalaCards integrated aliases for Salivary Gland Disease:

Name: Salivary Gland Disease 12 53 15 17
Salivary Gland Disorders 74 42
Salivary Gland Diseases 54 71
Non-Neoplastic Salivary Gland Disorder 71
Non-Neoplastic Salivary Gland Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10854
ICD9CM 34 527.8
ICD10 32 K11
UMLS 71 C0029773 C0036093 C1335041

Summaries for Salivary Gland Disease

NINDS : 53 Cytomegalovirus (CMV) is a virus found throughout the world that infects between 50 to 80 percent of all adults in the United States by the age of 40.  CMV is in the same family of viruses that causes cold sores (herpes simplex virus), infectious mononucleosis (Epstein-Barr virus), and chickenpox/shingles (varicella zoster virus).    Most people who acquire CVM as children or adults display no signs of illness or have mild symptoms such as fever, fatigue, or tender lymph nodes.  People with a compromised immune system may have more severe forms of infection involving the nervous system. A hallmark of CMV infection is that the virus cycles through periods of dormancy and active infection during the life of the individual  Infected persons of any age periodically shed the virus in their body fluids, such as saliva, urine, blood, tears, semen, or breast milk.  CMV is most commonly transmitted when infected body fluids come in contact with the mucous membranes of an uninfected person, but the virus can also pass from mother to fetus during pregnancy.

MalaCards based summary : Salivary Gland Disease, also known as salivary gland disorders, is related to igg4-related disease and mikulicz disease, and has symptoms including halitosis, snoring and oral manifestations. An important gene associated with Salivary Gland Disease is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are ICos-ICosL Pathway in T-Helper Cell and Cell adhesion molecules (CAMs). The drugs Ciprofloxacin and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, lymph node and breast, and related phenotype is endocrine/exocrine gland.

MedlinePlus : 42 Your salivary glands are in your mouth. You have three pairs of major salivary glands and hundreds of small (minor) glands. They make saliva (spit) and empty it into your mouth through openings called ducts. Saliva makes your food moist, which helps you chew and swallow. It helps you digest your food. It also cleans your mouth and contains antibodies that can kill germs. Problems with salivary glands can cause them to become irritated and swollen. You may have symptoms such as A bad taste in your mouth Difficulty opening your mouth Dry mouth Pain in your face or mouth Swelling of your face or neck Causes of salivary gland problems include infections, obstruction, or cancer. Problems can also be due to other disorders, such as mumps or Sjogren's syndrome.

Wikipedia : 74 Salivary gland diseases (SGD) are multiple and varied in... more...

Related Diseases for Salivary Gland Disease

Diseases related to Salivary Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 381)
# Related Disease Score Top Affiliating Genes
1 igg4-related disease 32.9 ICOSLG CD4 CCR6
2 mikulicz disease 32.1 ICOSLG CD4 CCR6
3 sialadenitis 31.9 ICOSLG CD8A CD4 CCR6
4 pleomorphic adenoma 31.2 MAML2 KRT7 CRTC1
5 diffuse infiltrative lymphocytosis syndrome 31.0 CD8A CD4
6 mucoepidermoid carcinoma 30.9 SERPINA3 MAML2 KRT7 CRTC1
7 immune deficiency disease 30.8 ICOSLG H2AC18 CD40LG CD4 CCR6
8 adenoid cystic carcinoma 30.8 SERPINA3 NFIB KRT7 CYLD ACCS
9 lymphadenitis 30.7 SERPINA3 ICOSLG CD4 CCR6
10 granulomatosis with polyangiitis 30.7 ICOSLG CD40LG CD4 CCR6
11 mastitis 30.7 TST SETBP1 H2AC18 CCR6
12 necrotizing sialometaplasia 30.7 MAML2 KRT7
13 acinar cell carcinoma 30.7 SERPINA3 MAML2 KRT7 ACCS
14 bacterial infectious disease 30.7 SERPINA3 ICOSLG H2AC18 CD8A CD40LG CD4
15 viral infectious disease 30.6 ICOSLG H2AC18 CD40LG CD4 CCR6
16 sarcoidosis 1 30.5 SERPINA3 ICOSLG CD8A CD40LG CD4 CCR6
17 lacrimal gland mucoepidermoid carcinoma 10.8 MAML2 CRTC1
18 schneiderian carcinoma 10.7 MAML2 CRTC1
19 riedel's fibrosing thyroiditis 10.7 CD40LG CD4
20 cutaneous mucoepidermoid carcinoma 10.7 MAML2 KRT7 CRTC1
21 breast secretory carcinoma 10.7 SERPINA3 NFIB MAML2
22 autoimmune vasculitis 10.7 H2AC18 CD4 CCR6
23 pleomorphic adenoma carcinoma 10.7 NFIB MAML2 CRTC1
24 gastric squamous cell carcinoma 10.7 SERPINA3 KRT7 CCR6
25 chancroid 10.7 CD40LG CD4 CCR6
26 breast mucoepidermoid carcinoma 10.7 MAML2 CRTC1
27 bile duct mucoepidermoid carcinoma 10.7 MAML2 KRT7 CRTC1
28 breast metaplastic carcinoma 10.7 MAML2 KRT7 CRTC1
29 immunodeficiency with hyper-igm, type 2 10.7 ICOSLG H2AC18 CD40LG
30 chronic conjunctivitis 10.7 ICOSLG CD4 CCR6
31 clear cell hidradenoma 10.7 MAML2 KRT7 CRTC1
32 hidradenoma 10.7 MAML2 KRT7 CRTC1
33 lipoadenoma 10.7 SERPINA3 KRT7 CRTC1
34 scleral disease 10.7 CD40LG CD4 CCR6
35 autoimmune neuropathy 10.7 ICOSLG CD40LG CD4
36 acinar cell cystadenocarcinoma 10.7 SERPINA3 ACCS
37 warthin tumor 10.7 MAML2 KRT7 CRTC1
38 nut allergy 10.7 ICOSLG CD4 CCR6
39 malignant spiradenoma 10.7 KRT7 CYLD
40 iritis 10.7 CD40LG CD4 CCR6
41 endobronchial lipoma 10.7 MAML2 KRT7 CRTC1
42 cork-handlers' disease 10.7 CD8A CD40LG CD4
43 spongiotic dermatitis 10.7 CD8A CD4 CCR6
44 papillary cystadenocarcinoma 10.7 SERPINA3 MAML2 KRT7
45 pyelitis 10.7 SERPINA3 CD40LG CCR6
46 anus basaloid carcinoma 10.7 KRT7 CYLD
47 syphilitic meningitis 10.7 CD8A CD40LG CD4
48 lacrimal system cancer 10.7 NFIB MAML2 ACCS
49 myelitis 10.7 ICOSLG CD40LG CCR6
50 autoimmune disease of peripheral nervous system 10.7 ICOSLG CD40LG CD4

Graphical network of the top 20 diseases related to Salivary Gland Disease:



Diseases related to Salivary Gland Disease

Symptoms & Phenotypes for Salivary Gland Disease

UMLS symptoms related to Salivary Gland Disease:


halitosis, snoring, oral manifestations

MGI Mouse Phenotypes related to Salivary Gland Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.28 CD4 CD40LG CD8A CRTC1 CYLD ISL1

Drugs & Therapeutics for Salivary Gland Disease

Drugs for Salivary Gland Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
2 Anti-Infective Agents Phase 3
3 Cytochrome P-450 Enzyme Inhibitors Phase 3
4 Topoisomerase Inhibitors Phase 3
5 Anti-Bacterial Agents Phase 3
6 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
7
Amifostine Approved, Investigational Phase 2 20537-88-6 2141
8
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 2 53-43-0 9860744
9 Protective Agents Phase 2
10 Radiation-Protective Agents Phase 2
11 DHEA (Dehydroepiandrosterone) Phase 2
12 Adjuvants, Immunologic Phase 2
13 Androgens Phase 2
14 Immunologic Factors Phase 2
15 Ginger Approved
16
Chamomile Approved, Experimental, Investigational
17 Orange Approved
18 Immunoglobulin G
19 Antibodies
20 Immunoglobulins

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 BK Virus in Salivary Gland Disease Completed NCT02068846 Phase 3 Ciprofloxacin;Placebo
2 A Multi-institutional, Randomized Parallel Controlled, Phase II Clinical Trial on Comparison of Effectiveness and Safeness of Amifostine Every-other-day Regimen and Everyday Regimen From Monday to Friday Unknown status NCT01762514 Phase 2 Amifostine every-other-day regimen;Amifostine everyday regimen
3 Dehydroepiandrosterone (DHEA) Treatment for Sjogren's Syndrome Completed NCT00001598 Phase 2 Dehydroepiandrosterone
4 An Adaptive Phase 2 Randomized Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Multiple LOU064 Doses in Patients With Moderate to Severe Sjögren's Syndrome (LOUiSSe) Recruiting NCT04035668 Phase 2 LOU064;Placebo
5 A Phase I Open Label Study Evaluating the Safety and Feasibility of Allogeneic Mesenchymal Stem Cells for Radiation-induced Hyposalivation and Xerostomia in Previous Oropharynx Cancer Patients Recruiting NCT03874572 Phase 1
6 Prospective, Pilot, Comparative, Monocentric Study of Diagnosis Capabilities of the Three-dimensional Cone-Beam CT Sialography (3D-CBCT Sialography) and MRI Sialography in Non-tumor Salivary Diseases Unknown status NCT02883140
7 A Pilot Study to Evaluate the Feasibility of Combining Submandibular Salivary Gland Transfer Procedure and Intensity Modulated Radiation Therapy (Helical Tomotherapy) to Reduce Dryness of Mouth (Xerostomia) in Head and Neck Cancer Patients After Surgery Unknown status NCT00497406
8 Randomized Clinical Trial of a Ginger and Cardamom Gelatin Compared to a Camomile and Lemon Juice Infusion in Control of Xerostomy in Terminally Ill Patients Completed NCT01915966
9 Salivary Evaluation in Healthy Volunteers Completed NCT00001390
10 Natural History of Salivary Gland Dysfunction and Sjogren's Syndrome Completed NCT00001852
11 A Survey of Patients With Elevated Serum IGG4 With Unknown IGG4-related Disease to Whom Biopsy and Performance of Subsequent Specific Staining for Clinical, Laboratory and Pathologic Correlation. Completed NCT02229448
12 Characterization of Diseases With Salivary Gland Involvement Recruiting NCT02327884
13 Combined Role of Color Doppler and Diffusion Weighted MRI In Differentiation Between Benign and Malignant Tumors of Major Salivary Glands Not yet recruiting NCT03893812
14 ROLE OF Gray Scale and Doppler Ultrasound in Diagnosis of Parotid and Submandibular Gland Diseases Not yet recruiting NCT03746730
15 Treatment of Juvenile Recurrent Parotitis: the Yield of Minimally Invasive Intervention, a Prospective Controlled Study Not yet recruiting NCT04074694

Search NIH Clinical Center for Salivary Gland Disease

Genetic Tests for Salivary Gland Disease

Anatomical Context for Salivary Gland Disease

MalaCards organs/tissues related to Salivary Gland Disease:

40
Salivary Gland, Lymph Node, Breast, Thyroid, Colon, Myeloid

Publications for Salivary Gland Disease

Articles related to Salivary Gland Disease:

(show top 50) (show all 348)
# Title Authors PMID Year
1
A pain in the neck. 42
31753833 2019
2
Mucosa-associated lymphoid tissue lymphoma of the accessory parotid gland presenting as a simple cheek mass: A case report. 42
31490395 2019
3
Mumps. 42
31503310 2019
4
Lectin binding studies of parotid salivary glycoproteins in Sjögren's syndrome. 54 61
10451125 1999
5
Feasibility of 3D printed salivary duct models for sialendoscopic skills training: preliminary report. 61
31845035 2019
6
Juvenile sclerosing polycystic adenosis cytologically mimicking Warthin tumor. 61
31329351 2019
7
TNF-α Suppresses Autophagic Flux in Acinar Cells in IgG4-Related Sialadenitis. 61
31461632 2019
8
Viral mumps: Increasing occurrences in the vaccinated population. 61
31326348 2019
9
Presentation is key to diagnosing salivary gland disorders. 61
31609364 2019
10
Application of diffusion-weighted magnetic resonance imaging in the diagnosis of salivary gland diseases: a systematic review. 61
31029591 2019
11
Successful treatment of tubulointerstitial nephritis in immunoglobulin G4-related disease with rituximab: A case report. 61
31531324 2019
12
Salivary glands require Aurora Kinase B for regeneration after transient innate immune-mediated injury. 61
31383943 2019
13
Beauty is only mucosa deep: a retrospective analysis of oral lumps and bumps caused by cosmetic fillers. 61
31444444 2019
14
Interrater Reliability of Ultrasound in the Diagnosis of Sialolithiasis. 61
30731479 2019
15
The spontaneous clearance of hepatitis E virus (HEV) and emergence of HEV antibodies in a transfusion-transmitted chronic hepatitis E case after completion of chemotherapy for acute myeloid leukemia. 61
31342463 2019
16
Human immunodeficiency virus and salivary gland pathology: an update. 61
30827854 2019
17
Sialendoscopy With Intraductal Steroid Irrigation in Patients With Sialadenitis Without Sialoliths. 61
31012349 2019
18
World Workshop on Oral Medicine VII: Immunobiologics for salivary gland disease in Sjögren's syndrome: A systematic review. 61
31140693 2019
19
Saliva as a Diagnostic Tool in Oral Squamous Cell Carcinoma - a Systematic Review with Meta Analysis. 61
30712193 2019
20
Rates of sialoendoscopy and sialoadenectomy in 5,111 adults with private insurance. 61
30556133 2019
21
Sialoendoscopy: Review and Nuances of Technique. 61
30728684 2019
22
Systematic review of the changing pattern of the oral manifestations of HIV. 61
30019446 2018
23
Extracorporeal lithotripsy of salivary gland stone: A 55 patients study. 61
29571815 2018
24
Immune response against the coiled coil domain of Sjögren's syndrome associated autoantigen Ro52 induces salivary gland dysfunction. 61
29465352 2018
25
Treating Mucocele in Pediatric Patients Using a Diode Laser: Three Case Reports. 61
29747378 2018
26
CD29 is highly expressed on epithelial, myoepithelial, and mesenchymal stromal cells of human salivary glands. 61
29197149 2018
27
Sialendoscopy in treating pediatric salivary gland disorders: a systematic review. 61
29204918 2018
28
Phenotypic Features and Salivary Parameters in Patients with Ectodermal Dysplasia: Report of Three Cases. 61
29854479 2018
29
Sialendoscopy for Definitive Management of a Submandibular Abscess following Radiotherapy for Oropharyngeal Squamous Cell Carcinoma. 61
30380549 2018
30
Combined classification system based on ACR/EULAR and ultrasonographic scores for improving the diagnosis of Sjögren's syndrome. 61
29614092 2018
31
Enhanced expression of IL-34 in an inflammatory cyst of the submandibular gland: a case report. 61
30002743 2018
32
Is there a role for ultrasound-guided balloon sialoplasty technique in salivary gland structures. 61
28707525 2017
33
Sialendoscopic Approach in Management of Juvenile Recurrent Parotitis. 61
29238673 2017
34
Oral manifestations of systemic disease. 61
29123296 2017
35
Head and Neck Lymphomas in HIV Patients: a Clinical Perspective. 61
29018505 2017
36
HIV-associated benign lymphoepithelial cysts of the parotid glands confirmed by HIV-1 p24 antigen immunostaining. 61
28963391 2017
37
Oral Candidal Carriage in Subjects with Pure Vegetarian and Mixed Dietary Habits. 61
28893036 2017
38
[Guidelines for the use of sialendoscopy in salivary gland diseases]. 61
28412788 2017
39
Diagnostic work-up in obstructive and inflammatory salivary gland disorders. 61
28516970 2017
40
Gene Therapy of Salivary Diseases. 61
27924590 2017
41
Biomarkers in Autoimmune Salivary Gland Disorders: A Review. 61
28231569 2017
42
Chronic Recurrent Non-specific Parotitis: A Case Report and Review. 61
28458496 2017
43
Outcomes of interventional sialendoscopy for obstructive salivary gland disorders: an Italian multicentre study. 61
28177330 2016
44
Device failure in sialoendoscopy: Intraoperative practical decision-making. 61
27729130 2016
45
Distribution of oral and maxillofacial lesions in pediatric patients from a Brazilian southeastern population. 61
27729142 2016
46
Pediatric sialendoscopy in Asians: A preliminary report. 61
27325357 2016
47
Botulinum Neurotoxin A for Parotid Enlargement in Cystic Fibrosis: The First Case Report. 61
27131031 2016
48
A Case of HIV-associated Salivary Gland Disease (HSD) Presenting with Bilateral Parotid Abscesses. 61
30035904 2016
49
Dysgenetic polycystic disease of the minor and submandibular salivary glands. 61
26855244 2016
50
Distinct BK polyomavirus non-coding control region (NCCR) variants in oral fluids of HIV- associated Salivary Gland Disease patients. 61
27085139 2016

Variations for Salivary Gland Disease

Expression for Salivary Gland Disease

Search GEO for disease gene expression data for Salivary Gland Disease.

Pathways for Salivary Gland Disease

Pathways related to Salivary Gland Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.84 NR4A1 ICOSLG CD40LG CD4
2 11.42 ICOSLG CD8A CD40LG CD4
3 11.34 CD8A CD4 CCR6
4 10.38 CD8A CD40LG CD4

GO Terms for Salivary Gland Disease

Cellular components related to Salivary Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 ICOSLG CD8A CD40LG CD4 CCR6

Biological processes related to Salivary Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell activation GO:0042110 8.8 ICOSLG CD8A CD4

Sources for Salivary Gland Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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