MCID: SLP003
MIFTS: 44

Salpingitis

Categories: Reproductive diseases
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Aliases & Classifications for Salpingitis

MalaCards integrated aliases for Salpingitis:

Name: Salpingitis 11 53 43 14 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:5733
MeSH 43 D012488
NCIt 49 C26880
SNOMED-CT 68 155968004
UMLS 71 C0036130

Summaries for Salpingitis

Disease Ontology: 11 A fallopian tube disease that is characterized by inflammation of the fallopian tube.

MalaCards based summary: Salpingitis is related to chronic salpingitis and pyosalpinx. An important gene associated with Salpingitis is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Cetrorelix and Follitropin have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and appendix, and related phenotypes are neoplasm and digestive/alimentary

Wikipedia: 75 Salpingitis is an infection causing inflammation in the Fallopian tubes (also called salpinges). It is... more...

Related Diseases for Salpingitis

Diseases in the Salpingitis family:

Acute Salpingitis Chronic Salpingitis

Diseases related to Salpingitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 835)
# Related Disease Score Top Affiliating Genes
1 chronic salpingitis 31.9 TNF OVGP1 ODF3 AMH
2 pyosalpinx 31.0 ODF3 ENSG00000262202 CRP
3 ectopic pregnancy 31.0 MIR1288 MIR1247 HSPD1 AMH
4 pelvic inflammatory disease 30.8 TLR4 TLR2 HSPD1 CRP
5 haemophilus influenzae 30.3 TNF TLR2 IL1B CXCL8
6 intestinal obstruction 30.2 TNF IL6 CRP
7 hemometra 30.0 ENSG00000262202 AMH
8 endometritis 29.9 TNF TLR4 TLR2 SIGLEC5 IL6 IL1B
9 chlamydia 29.9 TNF TLR4 TLR2 IL6 IL1B IL10
10 trachoma 29.9 TNF IL6 IL10
11 thrombocytosis 29.8 IL6 IL1B CRP
12 genital herpes 29.8 TNF TLR2 CD4
13 vulvovaginitis 29.8 IL10 HSPD1 CXCL8
14 disseminated intravascular coagulation 29.7 TNF IL6 IL10 CRP
15 syphilis 29.7 TNF TLR2 CRP CD4
16 henoch-schoenlein purpura 29.7 TNF IL6 CRP CD4
17 peritonitis 29.6 TNF TLR4 TLR2 IL6 IL1B IL10
18 pericarditis 29.6 TNF IL6 IL1B CXCL8 CRP
19 miliary tuberculosis 29.5 TNF IL10 CRP CD4
20 appendicitis 29.5 TNF TLR4 IL6 IL1B IL10 CXCL8
21 conjunctivitis 29.5 TNF TLR4 IL6 IL10 CXCL8
22 bowel dysfunction 29.5 TNF IL6 IL1B IL10 CRP
23 pfeiffer syndrome 29.5 TNF IL10 CRP CD4
24 glanders 29.4 TLR4 HSPD1 CD4
25 vaginal discharge 29.4 TNF IL6 IL1B IL10 CXCL8 CRP
26 actinomycosis 29.4 TNF IL10 HSPD1 CRP CD4
27 adult respiratory distress syndrome 29.2 TNF IL6 IL1B IL10 CXCL8 CRP
28 allergic disease 29.2 TNF IL6 IL1B IL10 CXCL8 CD4
29 cystitis 29.2 TNF TLR4 IL6 CXCL8 CRP
30 bacterial vaginosis 29.2 TNF TLR2 IL6 IL1B IL10 CXCL8
31 echinococcosis 29.1 TNF TLR4 TLR2 IL6 IL10
32 enterocolitis 28.9 TNF TLR4 IL6 IL10 CXCL8 CRP
33 exanthem 28.8 TNF IL6 IL1B IL10 CXCL8 CRP
34 toxic shock syndrome 28.8 TNF TLR4 TLR2 IL6 IL1B IL10
35 mycobacterium tuberculosis 1 28.8 TNF TLR4 TLR2 IL6 IL10 HSPD1
36 rhinitis 28.7 TNF TLR4 IL6 IL1B IL10 CXCL8
37 diarrhea 28.7 TNF TLR4 IL6 IL1B IL10 CXCL8
38 cervicitis 28.7 TNF TLR4 TLR2 IL6 IL1B IL10
39 acute pancreatitis 28.6 TNF TLR4 IL6 IL1B IL10 CXCL8
40 candidiasis 28.6 TNF TLR4 TLR2 IL6 IL1B IL10
41 immune deficiency disease 28.6 TNF TLR2 SIGLEC5 IL6 IL1B IL10
42 urethritis 28.4 TNF TLR4 TLR2 IL6 IL1B IL10
43 inflammatory bowel disease 28.3 TNF TLR4 TLR2 IL6 IL1B IL10
44 respiratory failure 28.2 TNF TLR4 IL6 IL1B IL10 CXCL8
45 amebiasis 28.2 TNF TLR4 TLR2 IL6 IL1B IL10
46 crohn's disease 28.1 TNF TLR4 TLR2 SIGLEC5 IL6 IL1B
47 vaginitis 28.0 TNF TLR4 TLR2 IL6 IL1B IL10
48 urinary tract infection 28.0 TNF TLR4 TLR2 IL6 IL1B IL10
49 eye disease 28.0 TNF TLR4 TLR2 IL6 IL1B IL10
50 salpingitis isthmica nodosa 11.6

Graphical network of the top 20 diseases related to Salpingitis:



Diseases related to Salpingitis

Symptoms & Phenotypes for Salpingitis

MGI Mouse Phenotypes related to Salpingitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.76 AMH CEACAM1 IL10 IL1B IL6 TLR2
2 digestive/alimentary MP:0005381 9.56 CD4 CEACAM1 IL10 IL6 IREB2 TLR2
3 integument MP:0010771 9.28 CD4 HSPD1 IL10 IL1B IL6 IREB2

Drugs & Therapeutics for Salpingitis

Drugs for Salpingitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cetrorelix Approved, Investigational 120287-85-6 25074887
2
Follitropin Approved, Vet_approved 97048-13-0, 146479-72-3, 9002-68-0 62819
3
Ganirelix Approved 124904-93-4 44208957 16186319 16130966
4
Imidacloprid Vet_approved 105827-78-9 86418
5 Anesthetics
6 Antineoplastic Agents, Hormonal
7 Hormones
8 Hormone Antagonists
9 Contraceptive Agents
10
Triptorelin Pamoate
11 Chorionic Gonadotropin
12 Prolactin Release-Inhibiting Factors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Feasibility of Balloon Dilation of the Eustachian Tubes for Dilatory Dysfunction Under Local Anesthesia Unknown status NCT04055714
2 Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Women With Infertility Problems Active, not recruiting NCT04071574 Human Chorionic Gonadotropin (hCG);Gonadotropins;GNRH-A Triptorelin;GnRH antagonist

Search NIH Clinical Center for Salpingitis

Cochrane evidence based reviews: salpingitis

Genetic Tests for Salpingitis

Anatomical Context for Salpingitis

Organs/tissues related to Salpingitis:

MalaCards : Uterus, Cervix, Appendix, Ovary, Kidney, B Cells, Bone

Publications for Salpingitis

Articles related to Salpingitis:

(show top 50) (show all 1534)
# Title Authors PMID Year
1
PID: clinical and laparoscopic aspects. 53 62
10818418 2000
2
Serological responses of patients with ectopic pregnancy to epitopes of the Chlamydia trachomatis 60 kDa heat shock protein. 53 62
9619577 1998
3
Antibodies to the chlamydial 60 kd heat-shock protein are associated with laparoscopically confirmed perihepatitis. 53 62
9125613 1997
4
Proliferative response to conserved epitopes of the Chlamydia trachomatis and human 60-kilodalton heat-shock proteins by lymphocytes from women with salpingitis. 53 62
7520213 1994
5
Tuberculous Salpingitis - possible cause of salpingo-enteric fistula. 62
36439924 2023
6
MR of Fallopian Tubes: MR Imaging Clinics. 62
36368860 2023
7
The dual role of cytokine responses to Chlamydia trachomatis infection in host pathogen crosstalk. 62
36209970 2022
8
Surgical disorders in pediatric and adolescent gynecology: Adnexal abnormalities. 62
36373872 2022
9
Clinical significance of isolation of Haemophilus no ducreyi in genital samples. Systematic review. 62
36443187 2022
10
End of lay postmortem findings in aviary housed laying hens. 62
36473383 2022
11
Effects of salpingitis simulation on the morphology and expression of inflammatory-related genes of oviduct in laying hens. 62
36335735 2022
12
Symptom Localization May Differentiate Subtypes of Eustachian Tube Dysfunction. 62
36222454 2022
13
Electroacupuncture attenuates chronic salpingitis transforming growth factor-β1/p38 mitogen-activated protein kinase signaling pathway. 62
36083486 2022
14
Detection and genetic characterization of novel infectious bronchitis viruses from recent outbreaks in broiler and layer chicken flocks in southern China, 2021. 62
36041395 2022
15
Research Note: Disturbance of intracellular calcium signal in salpingitis simulation of laying hens. 62
36402046 2022
16
[Intra-abdominal infections in adults caused by Streptococcus pneumoniae: report of 18 cases] 62
36149071 2022
17
Pseudoxanthomatous salpingitis: An uncommon lesion of the fallopian tube. 62
36101780 2022
18
Associations between ubiquitin, follicle-stimulating hormone, and sex steroid hormones in the failed to conceive female dromedary camels raised in hot climates. 62
36313844 2022
19
Expression of Hormones, Cytokines, and Antioxidants in Heat-Stressed Subfertile Female Dromedaries. 62
36009715 2022
20
The immune cell profile of human fallopian tubes in health and benign pathology: a systematic review. 62
35644062 2022
21
Bovine salpingitis: Histopathology, bacteriology, cytology and transcriptomic approaches and its impact on the oocyte competence. 62
35644050 2022
22
Longitudinal study on background lesions in broiler breeder flocks and their progeny, and genomic characterisation of Escherichia coli. 62
35799204 2022
23
[Pseudoxanthomatous salpingitis]. 62
35000781 2022
24
Necrotizing Salpingitis by Fowl Adenovirus in a Backyard Hen. 62
35510474 2022
25
The association between common urogenital infections and cervical neoplasia - A nationwide cohort study of over four million women (2002-2018). 62
35494213 2022
26
Evaluation of the safety and effectiveness of tubal inflammatory drugs in patients with incomplete tubal obstruction after four-dimensional hysterosalpingo-contrast-sonography examination. 62
35525936 2022
27
Modified Gexiazhuyu decoction alleviates chronic salpingitis p38 signaling pathway. 62
35473341 2022
28
Maternal disease factors associated with neonatal jaundice: a case-control study. 62
35331174 2022
29
Peritonitis caused by group A streptococcus: A case report and literature review. 62
35240481 2022
30
Kurthia gibsonii, a novel opportunistic pathogen in poultry. 62
34662527 2022
31
HEALTHCARE-ASSOCIATED TUBO-OVARIAN INFECTIONS IN UKRAINE: RESULTS OF A MULTICENTER STUDY (2020-2022). 62
36129086 2022
32
Adnexal torsion caused by tuberculous pyosalpinx: An uncommon case report of urogenital tuberculosis. 62
34896778 2022
33
INFECTIONS ASSOCIATED WITH OBSTETRIC AND GYNECOLOGICAL SURGERIES AS A CAUSE OF FEMALE INFERTILITY IN UKRAINE. 62
35962672 2022
34
SURGICAL SITE INFECTION AFTER LAPAROSCOPIC HYSTERECTOMY FOR BENIGN GYNECOLOGICAL DISEASE IN UKRAINE. 62
35182131 2022
35
[Emergency combined surgery for acute appendicitis and cystic lesions of small pelvis]. 62
35146997 2022
36
Diagnostic Value and Clinical Application of Diffusion-Weighted Magnetic Resonance Imaging for Female Pelvic Lesions. 62
35833078 2022
37
Fitz-Hugh-Curtis syndrome without salpingitis: Should contrast-enhanced computed tomography be a routine diagnostic procedure? 62
34938563 2021
38
Evaluating Fallopian Tube Patency: What the Radiologist Needs to Know. 62
34597232 2021
39
Chlamydia trachomatis Cross-Serovar Protection during Experimental Lung Reinfection in Mice. 62
34451996 2021
40
The Continued Challenges in the Diagnosis of Acute Pelvic Inflammatory Disease: Focus on Clinically Mild Disease. 62
34396404 2021
41
Prophylactic Multi-Subunit Vaccine against Chlamydia trachomatis: In Vivo Evaluation in Mice. 62
34204170 2021
42
Co-Infection of Escherichia coli, Enterococcus faecalis and Chlamydia psittaci Contributes to Salpingitis of Laying Layers and Breeder Ducks. 62
34203970 2021
43
MiR-378b Modulates Chlamydia-Induced Upper Genital Tract Pathology. 62
34067003 2021
44
Successful laparoscopic resection of ovarian abscess caused by Staphylococcus aureus in a 13-year-old girl: a case report and review of literature. 62
33985484 2021
45
Recurrent Bilateral Salpingitis in a Sexually Inactive Adolescent: Don't Forget about the Appendix. 62
33358895 2021
46
Adrenal Cortical Rests in the Fallopian Tube: Report of a Case and Review of the Literature. 62
33809106 2021
47
Effects of age, weight, and housing system on prevalence of dead on arrival and carcass condemnation causes in laying hens. 62
33518312 2021
48
Ruptured salpingitis isthmica nodosa: a rare cause for spontaneous haemoperitoneum. 62
33500302 2021
49
HEALTHCARE ASSOCIATED DEEP PELVIC TISSUE INFECTION AND OTHER INFECTIONS OF THE FEMALE REPRODUCTIVE TRACT IN UKRAINE. 62
33813441 2021
50
HEALTHCARE ASSOCIATED INFECTION AFTER LEGAL INDUCED ABORTIONS IN UKRAINE: RESULTS A MULTICENTER STUDY. 62
34459752 2021

Variations for Salpingitis

Expression for Salpingitis

Search GEO for disease gene expression data for Salpingitis.

Pathways for Salpingitis

Pathways related to Salpingitis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 CD4 CEACAM1 CRP CXCL8 IL10 IL1B
2
Show member pathways
13.41 TNF TLR4 TLR2 IL6 IL1B IL10
3
Show member pathways
12.86 CXCL8 IL1B IL6 TLR2 TLR4 TNF
4
Show member pathways
12.71 TNF TLR4 TLR2 IL6 IL1B
5
Show member pathways
12.63 TNF TLR2 IL6 IL1B CXCL8
6
Show member pathways
12.62 TNF IL6 IL1B IL10 CXCL8
7
Show member pathways
12.6 TNF IL6 IL1B IL10 CD4
8 12.58 TNF TLR2 IL1B IL10 CEACAM1
9
Show member pathways
12.57 CXCL8 IL1B IL6 TLR2 TLR4 TNF
10
Show member pathways
12.47 TNF TLR4 TLR2 IL6 IL1B CXCL8
11
Show member pathways
12.35 TNF TLR4 IL6 IL1B CXCL8
12
Show member pathways
12.29 CXCL8 IL6 TLR2 TNF
13 12.21 TNF TLR4 TLR2 IL6
14 12.12 TNF IL6 IL1B IL10
15 12.11 TNF IL6 IL1B IL10 HSPD1 CXCL8
16 12.07 TNF IL6 IL10 CEACAM1 CD4
17 12.06 TNF TLR4 IL6 IL1B CXCL8
18 12.02 TNF IL6 IL1B IL10 CXCL8
19 11.92 TNF IL1B IL10 CXCL8
20
Show member pathways
11.91 TLR4 TLR2 IL6 IL1B CD4
21 11.88 IL6 IL10 CXCL8
22
Show member pathways
11.86 TLR4 IL6 CXCL8
23 11.85 TNF IL1B IL10 CD4
24
Show member pathways
11.83 IL6 CXCL8 CRP CD4
25 11.81 TLR4 IL6 IL10 CD4
26 11.8 CXCL8 IL1B IL6 TLR4 TNF
27 11.78 TNF IL6 IL1B IL10 CD4
28 11.73 CXCL8 IL1B IL6 TNF
29
Show member pathways
11.73 CXCL8 IL1B IL6 TNF
30 11.73 TNF TLR4 IL6 IL10 CRP
31 11.72 IL6 IL1B CD4
32 11.72 IL6 IL10 CXCL8
33 11.63 TNF TLR4 IL6 CXCL8
34 11.61 TNF TLR4 CD4
35 11.6 TNF TLR4 TLR2 IL1B
36 11.59 IL10 IL1B IL6 TLR4 TNF
37 11.58 TNF IL10 CXCL8
38 11.56 CXCL8 IL10 IL6 TLR4 TNF
39 11.52 TNF IL6 IL1B
40 11.49 TNF TLR4 IL6
41
Show member pathways
11.49 TNF TLR4 TLR2 IL6 IL10
42 11.35 TNF IL6 IL1B CXCL8
43 11.34 TNF IL6 IL1B
44 11.33 TNF IL6 IL1B IL10 CXCL8
45 11.3 TNF IL6 IL1B CXCL8
46 11.27 TNF IL6 IL10 CXCL8
47
Show member pathways
11.17 TNF TLR4 TLR2 IL6 IL1B IL10
48 11.12 TLR4 IL6 IL1B IL10
49 11.1 TNF TLR4 IL6 IL1B IL10
50 11.04 TNF IL6 CXCL8 CRP

GO Terms for Salpingitis

Cellular components related to Salpingitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide receptor complex GO:0046696 8.92 TLR4 HSPD1

Biological processes related to Salpingitis according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell population proliferation GO:0008285 10.4 TNF TLR2 IL6 IL1B IL10 CXCL8
2 inflammatory response GO:0006954 10.39 CRP CXCL8 IL1B IL6 TLR2 TLR4
3 positive regulation of gene expression GO:0010628 10.31 AMH CRP CXCL8 IL1B IL6 TLR2
4 positive regulation of DNA-binding transcription factor activity GO:0051091 10.27 TNF IL6 IL1B IL10
5 positive regulation of inflammatory response GO:0050729 10.25 IL1B TLR2 TLR4 TNF
6 defense response to Gram-positive bacterium GO:0050830 10.24 TNF TLR2 IL6 IL1B CRP
7 positive regulation of type II interferon production GO:0032729 10.21 TNF TLR4 IL1B HSPD1
8 positive regulation of NIK/NF-kappaB signaling GO:1901224 10.19 TNF TLR4 TLR2 IL1B
9 regulation of insulin secretion GO:0050796 10.17 TNF IL6 IL1B
10 response to activity GO:0014823 10.16 TNF IL6 IL10
11 positive regulation of interleukin-12 production GO:0032735 10.15 TLR4 TLR2 HSPD1
12 positive regulation of nitric oxide biosynthetic process GO:0045429 10.15 IL1B TLR4 TNF
13 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.14 TNF IL6 IL10
14 liver regeneration GO:0097421 10.12 TNF IL6 IL10
15 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.11 TNF TLR4 IL6
16 negative regulation of neurogenesis GO:0050768 10.11 TNF IL6 IL1B
17 response to lipopolysaccharide GO:0032496 10.11 TNF TLR4 TLR2 IL1B IL10
18 cellular response to lipopolysaccharide GO:0071222 10.11 TNF TLR4 IL6 IL1B IL10 CXCL8
19 immune response GO:0006955 10.1 TNF TLR4 TLR2 IL6 IL1B IL10
20 B cell proliferation GO:0042100 10.09 TLR4 IL10 HSPD1
21 MyD88-dependent toll-like receptor signaling pathway GO:0002755 10.08 TLR4 TLR2 HSPD1
22 positive regulation of macrophage activation GO:0043032 10.08 HSPD1 IL10 TLR4
23 positive regulation of interleukin-10 production GO:0032733 10.08 TLR4 TLR2 IL6 HSPD1
24 positive regulation of glial cell proliferation GO:0060252 10.07 TNF IL6 IL1B
25 lipopolysaccharide-mediated signaling pathway GO:0031663 10.06 TNF TLR4 TLR2 IL1B
26 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.05 IL10 IL1B TNF
27 positive regulation of NF-kappaB transcription factor activity GO:0051092 10 AMH IL1B IL6 TLR2 TLR4 TNF
28 positive regulation of oxidative stress-induced neuron death GO:1903223 9.99 TNF TLR4
29 positive regulation of neuroinflammatory response GO:0150078 9.99 IL1B IL6 TNF
30 negative regulation of interleukin-1 production GO:0032692 9.98 IL10 CEACAM1
31 negative regulation of cytokine production involved in immune response GO:0002719 9.98 TNF IL10
32 positive regulation of fever generation GO:0031622 9.97 TNF IL1B
33 negative regulation of lipid storage GO:0010888 9.97 TNF IL6 CRP
34 sequestering of triglyceride GO:0030730 9.96 TNF IL1B
35 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.94 TNF IL1B
36 positive regulation of matrix metallopeptidase secretion GO:1904466 9.93 TLR4 TLR2
37 chronic inflammatory response to antigenic stimulus GO:0002439 9.92 IL10 TNF
38 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.92 TLR2 TLR4
39 response to molecule of bacterial origin GO:0002237 9.92 TLR2 IL10 CXCL8
40 vascular endothelial growth factor production GO:0010573 9.91 TNF IL6 IL1B
41 positive regulation of interleukin-8 production GO:0032757 9.85 TNF TLR4 TLR2 IL6 IL1B
42 response to external stimulus GO:0009605 9.73 TLR4 TLR2 CXCL8
43 positive regulation of chemokine production GO:0032722 9.61 TNF TLR4 TLR2 IL6 IL1B
44 positive regulation of interleukin-6 production GO:0032755 9.4 TNF TLR4 TLR2 IL6 IL1B HSPD1

Molecular functions related to Salpingitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide immune receptor activity GO:0001875 9.46 TLR4 TLR2
2 lipopolysaccharide binding GO:0001530 9.43 TLR4 TLR2 HSPD1
3 cytokine activity GO:0005125 9.28 TNF IL6 IL1B IL10 CXCL8

Sources for Salpingitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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