MCID: SRC003
MIFTS: 29

Sarcomatoid Basal Cell Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Sarcomatoid Basal Cell Carcinoma

MalaCards integrated aliases for Sarcomatoid Basal Cell Carcinoma:

Name: Sarcomatoid Basal Cell Carcinoma 12 15
Skin Sarcomatoid Basal Cell Carcinoma 12 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4303
NCIt 50 C38111
UMLS 70 C1519182

Summaries for Sarcomatoid Basal Cell Carcinoma

MalaCards based summary : Sarcomatoid Basal Cell Carcinoma, also known as skin sarcomatoid basal cell carcinoma, is related to basal cell carcinoma and myoepithelial carcinoma. An important gene associated with Sarcomatoid Basal Cell Carcinoma is PBX1 (PBX Homeobox 1), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Glucocorticoid receptor regulatory network. Affiliated tissues include skin and thymus, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Sarcomatoid Basal Cell Carcinoma

Graphical network of the top 20 diseases related to Sarcomatoid Basal Cell Carcinoma:



Diseases related to Sarcomatoid Basal Cell Carcinoma

Symptoms & Phenotypes for Sarcomatoid Basal Cell Carcinoma

GenomeRNAi Phenotypes related to Sarcomatoid Basal Cell Carcinoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-126 9.36 EWSR1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-137 9.36 EWSR1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-140 9.36 EWSR1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-146 9.36 EWSR1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.36 EWSR1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-52 9.36 EWSR1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.36 EWSR1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.36 EWSR1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-81 9.36 EWSR1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.36 EWSR1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-97 9.36 PBX1

Drugs & Therapeutics for Sarcomatoid Basal Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Sarcomatoid Basal Cell Carcinoma

Genetic Tests for Sarcomatoid Basal Cell Carcinoma

Anatomical Context for Sarcomatoid Basal Cell Carcinoma

MalaCards organs/tissues related to Sarcomatoid Basal Cell Carcinoma:

40
Skin, Thymus

Publications for Sarcomatoid Basal Cell Carcinoma

Articles related to Sarcomatoid Basal Cell Carcinoma:

# Title Authors PMID Year
1
"Primary cutaneous biphasic sarcomatoid basal cell carcinoma with myoepithelial carcinoma differentiation": Is it a new variant of sarcomatoid basal cell carcinoma or a collision tumor composed of a myoepithelial carcinoma and an incidental basal cell carcinoma? 61
31995232 2020
2
Reply to "Primary cutaneous biphasic sarcomatoid basal cell carcinoma with myoepithelial carcinoma differentiation. Is it a new variant of sarcomatoid basal cell carcinoma or a collision tumor composed of a myoepithelial carcinoma and an incidental basal cell carcinoma?" 61
32181509 2020
3
Primary cutaneous biphasic sarcomatoid basal cell carcinoma with myoepithelial carcinoma differentiation: A new variant. 61
31278765 2019
4
A case of a giant sarcomatoid basal cell carcinoma with heterologous osteosarcomatous elements. 61
24684278 2014
5
Study of D2-40 immunoexpression of the spindle cell areas of a metaplastic basal cell carcinoma (sarcomatoid basal cell carcinoma). 61
21602664 2012
6
Sarcomatoid basal cell carcinoma--predilection for osteosarcomatous differentiation: a series of 11 cases. 61
17001162 2006
7
Sarcomatoid basal cell carcinoma. 61
16314711 2005
8
Biphasic sarcomatoid basal cell carcinoma (carcinosarcoma): four cases with immunohistochemistry and review of the literature. 61
15606673 2005
9
Basal cell carcinoma with sarcomatoid features (sarcomatoid carcinoma): report of a case and review of the literature. 61
12928545 2003

Variations for Sarcomatoid Basal Cell Carcinoma

Cosmic variations for Sarcomatoid Basal Cell Carcinoma:

9 (show top 50) (show all 3424)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM84510986 ZNF276 skin,NS,carcinoma,basal cell carcinoma c.*940C>T p.? 16:89739186-89739186 3
2 COSM149268805 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 3
3 COSM87274302 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 3
4 COSM87270496 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 3
5 COSM149259613 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 3
6 COSM149268792 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 3
7 COSM87274307 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 3
8 COSM149268800 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 3
9 COSM87273325 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 3
10 COSM149304906 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 3
11 COSM87296537 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 3
12 COSM102023150 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7526C>T p.? 16:72958491-72958491 3
13 COSM102023155 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7920G>A p.? 16:72958885-72958885 3
14 COSM102019420 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.8105C>T p.S2702F 16:72787429-72787429 3
15 COSM149331772 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 3
16 COSM102023144 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.3083G>A p.G1028E 16:72796857-72796857 3
17 COSM102047764 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.8308G>A p.D2770N 16:72787226-72787226 3
18 COSM87286441 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 3
19 COSM102036925 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7190C>T p.? 16:72958155-72958155 3
20 COSM149266372 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 3
21 COSM102022243 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7097C>T p.? 16:72958062-72958062 3
22 COSM87274293 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 3
23 COSM104882801 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 3
24 COSM104236272 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 3
25 COSM101976974 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 3
26 COSM87040659 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
27 COSM101179498 TSC2 skin,NS,carcinoma,basal cell carcinoma c.1913C>T p.S638F 16:2071897-2071897 3
28 COSM150324396 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
29 COSM101191558 TSC2 skin,NS,carcinoma,basal cell carcinoma c.722C>T p.P241L 16:2058767-2058767 3
30 COSM147706701 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
31 COSM150353664 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
32 COSM151748023 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
33 COSM150576157 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
34 COSM149802478 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
35 COSM148980439 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
36 COSM90415129 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
37 COSM149800636 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
38 COSM148991757 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
39 COSM151753165 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
40 COSM151513825 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
41 COSM151371066 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
42 COSM148982237 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
43 COSM136628294 TSC2 skin,NS,carcinoma,basal cell carcinoma c.902C>T p.P301L 16:2058767-2058767 3
44 COSM110103971 TSC2 skin,NS,carcinoma,basal cell carcinoma c.568T>A p.C190S 16:2056674-2056674 3
45 COSM150583851 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
46 COSM102616914 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
47 COSM136618116 TSC2 skin,NS,carcinoma,basal cell carcinoma c.712T>A p.C238S 16:2056674-2056674 3
48 COSM110102044 TSC2 skin,NS,carcinoma,basal cell carcinoma c.1949C>T p.S650F 16:2071897-2071897 3
49 COSM150574866 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
50 COSM102629996 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3

Expression for Sarcomatoid Basal Cell Carcinoma

Search GEO for disease gene expression data for Sarcomatoid Basal Cell Carcinoma.

Pathways for Sarcomatoid Basal Cell Carcinoma

Pathways related to Sarcomatoid Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.24 PBX1 EWSR1
2 10.54 PBX1 KRT5

GO Terms for Sarcomatoid Basal Cell Carcinoma

Biological processes related to Sarcomatoid Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of ossification GO:0030278 8.62 PTGER4 PBX1

Sources for Sarcomatoid Basal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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