MCID: SRC001
MIFTS: 32

Sarcomatoid Mesothelioma

Categories: Cancer diseases

Aliases & Classifications for Sarcomatoid Mesothelioma

MalaCards integrated aliases for Sarcomatoid Mesothelioma:

Name: Sarcomatoid Mesothelioma 12 15 17 71
Malignant Fibrous Mesothelioma 12
Spindled Mesothelioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4488
NCIt 49 C45655
SNOMED-CT 67 399477001
UMLS 71 C0334513

Summaries for Sarcomatoid Mesothelioma

MalaCards based summary : Sarcomatoid Mesothelioma, also known as malignant fibrous mesothelioma, is related to benign mesothelioma and malignant epithelial mesothelioma. An important gene associated with Sarcomatoid Mesothelioma is CALB2 (Calbindin 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include lung, t cells and spinal cord, and related phenotypes are cardiovascular system and muscle

Related Diseases for Sarcomatoid Mesothelioma

Diseases related to Sarcomatoid Mesothelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 307)
# Related Disease Score Top Affiliating Genes
1 benign mesothelioma 31.2 WT1 THBD KRT5 CALB2
2 malignant epithelial mesothelioma 30.8 THBD CALB2
3 rare tumor 30.5 DES ACTC1
4 lymphohistiocytoid mesothelioma 30.5 THBD CDKN2A CALB2
5 fibrous histiocytoma 30.5 VIM DES ACTC1
6 lung sarcoma 30.5 NKX2-1 NAPSA CALB2
7 thymoma 30.2 NKX2-1 MUC1 CDKN2A CALB2
8 malignant fibrous histiocytoma 30.2 VIM MUC1 DES ACTC1
9 fibromatosis 30.0 VIM DES ACTC1
10 spindle cell sarcoma 30.0 VIM MUC1 DES ACTC1
11 sarcoma, synovial 29.9 WT1 VIM MUC1 DES CALB2
12 adenocarcinoma 29.9 NKX2-1 NAPSA MUC4 MUC1 CDKN2A
13 spindle cell carcinoma 29.7 VIM MUC1 KRT5 DES ACTC1
14 asbestosis 29.4 WT1 THBD MUC1 MSLN CALB2
15 peritoneal mesothelioma 29.4 WT1 VIM THBD MUC1 CDKN2A CALB2
16 pericardial mesothelioma 29.3 VIM S100A1 MUC1 KRT5 CALB2
17 sarcoma 29.2 WT1 VIM S100A1 MUC1 DES ACTC1
18 fibroma 29.1 VIM S100A1 DES CALB2 ACTC1
19 benign peritoneal mesothelioma 29.0 WT1 PDPN MUC1 MSLN KRT5 CALB2
20 malignant pleural mesothelioma 28.8 WT1 THBD PDPN NKX2-1 MUC1 MSLN
21 leiomyosarcoma 28.4 WT1 VIM S100A1 MUC1 DES CDKN2A
22 mesothelioma, malignant 26.9 WT1 VIM THBD PDPN NKX2-1 MUC1
23 fallopian tube carcinosarcoma 10.5 WT1 CALB2
24 gynandroblastoma 10.5 VIM CALB2
25 rete testis neoplasm 10.5 NKX2-1 CALB2
26 rete testis adenocarcinoma 10.5 NKX2-1 CALB2
27 epididymal neoplasm 10.5 WT1 CALB2
28 testicular gonadoblastoma 10.5 WT1 VIM
29 wolffian duct adenocarcinoma 10.5 WT1 CALB2
30 ovarian brenner tumor 10.5 WT1 THBD
31 juvenile type testicular granulosa cell tumor 10.5 WT1 CALB2
32 fallopian tube squamous cell carcinoma 10.5 WT1 CDKN2A
33 testicular granulosa cell tumor 10.5 WT1 CALB2
34 ovarian endometrioid stromal sarcoma 10.5 WT1 CALB2
35 nodular hidradenoma 10.5 VIM MUC1
36 ovarian gonadoblastoma 10.5 WT1 CALB2
37 ovarian germ cell teratoma 10.5 NKX2-1 CALB2
38 hobnail hemangioma 10.5 WT1 PDPN
39 ovarian seromucinous carcinoma 10.4 WT1 CDKN2A
40 localized pulmonary fibrosis 10.4 PDPN MUC1
41 esophageal adenoid cystic carcinoma 10.4 VIM PDPN
42 ovarian sex-cord stromal tumor 10.4 WT1 CALB2
43 thyroid angiosarcoma 10.4 THBD NKX2-1
44 colonic lymphangioma 10.4 PDPN MUC1
45 vulvar eccrine porocarcinoma 10.4 MUC1 CDKN2A
46 ameloblastic carcinoma 10.4 VIM CDKN2A
47 mucinous cystadenofibroma 10.4 NAPSA MUC1
48 ovarian serous cystadenofibroma 10.4 MUC1 CALB2
49 lymphangiectasis 10.4 VIM ACTC1
50 anaplastic ependymoma 10.4 VIM MUC1

Graphical network of the top 20 diseases related to Sarcomatoid Mesothelioma:



Diseases related to Sarcomatoid Mesothelioma

Symptoms & Phenotypes for Sarcomatoid Mesothelioma

MGI Mouse Phenotypes related to Sarcomatoid Mesothelioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 ACTC1 BAP1 CDKN2A DES NKX2-1 PDPN
2 muscle MP:0005369 9.56 ACTC1 BAP1 CDKN2A DES PDPN S100A1
3 respiratory system MP:0005388 9.23 BAP1 CDKN2A NKX2-1 PDPN S100A1 THBD

Drugs & Therapeutics for Sarcomatoid Mesothelioma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multi-centre, Two-stage, Open Label Phase II Study to Assess the Efficacy and Safety of APO866 in the Treatment of Patients With Advanced Melanoma. Completed NCT00432107 Phase 2 APO866
2 A Multicenter Open Label Phase II Study of to Assess the Efficacy and Safety of APO866 in the Treatment of Patients With Refractory or Relapsed Cutaneous T-cell Lymphoma Completed NCT00431912 Phase 2 APO866

Search NIH Clinical Center for Sarcomatoid Mesothelioma

Genetic Tests for Sarcomatoid Mesothelioma

Anatomical Context for Sarcomatoid Mesothelioma

MalaCards organs/tissues related to Sarcomatoid Mesothelioma:

40
Lung, T Cells, Spinal Cord, Colon, Uterus, Prostate, Testis

Publications for Sarcomatoid Mesothelioma

Articles related to Sarcomatoid Mesothelioma:

(show top 50) (show all 111)
# Title Authors PMID Year
1
Overexpression of miR-199/214 is a distinctive feature of iron-induced and asbestos-induced sarcomatoid mesothelioma in rats. 61
32248600 2020
2
Comprehensive Molecular and Pathologic Evaluation of Transitional Mesothelioma Assisted by Deep Learning Approach: A Multi-Institutional Study of the International Mesothelioma Panel from the MESOPATH Reference Center. 61
32165206 2020
3
The YAP1 Signaling Inhibitors, Verteporfin and CA3, Suppress the Mesothelioma Cancer Stem Cell Phenotype. 61
31732616 2020
4
Pleural sarcomatoid mesothelioma with an interstitial growth pattern. 61
31898836 2020
5
Expression of V-set immunoregulatory receptor in malignant mesothelioma. 61
31363159 2020
6
Peritoneal sarcomatoid mesothelioma in a sika deer. 61
31413229 2019
7
Heterologous sarcomatoid pleural mesothelioma with osteosarcomatous differentiation: a report of autopsy case that accomplished trimodality therapy and review of the literature. 61
31372931 2019
8
Prostate Carcinoma and Pleural Mesothelioma: An Extremely Rare Co-occurrence. 61
31316876 2019
9
Revisiting localized malignant mesothelioma. 61
30798074 2019
10
Immunohistochemical evaluation of nuclear 5-hydroxymethylcytosine (5-hmC) accurately distinguishes malignant pleural mesothelioma from benign mesothelial proliferations. 61
30315275 2019
11
Impact on survival of nuclear atypia in epithelioid malignant mesothelioma. 61
31038719 2019
12
Is There a Role for Cancer-Directed Surgery in Early-Stage Sarcomatoid or Biphasic Mesothelioma? 61
30278171 2019
13
[Clinical and pathological profile of the pleural malignant mesothelioma: A retrospective study about 30 cases]. 61
30293912 2018
14
A combination of MTAP and BAP1 immunohistochemistry is effective for distinguishing sarcomatoid mesothelioma from fibrous pleuritis. 61
30429020 2018
15
Highlights of the 14th international mesothelioma interest group meeting: Pathologic separation of benign from malignant mesothelial proliferations and histologic/molecular analysis of malignant mesothelioma subtypes. 61
30268487 2018
16
Sarcomatoid mesothelioma of tunica vaginalis testis in the right scrotum of a dog. 61
29794371 2018
17
Characterization of increasing stages of invasiveness identifies stromal/cancer cell crosstalk in rat models of mesothelioma. 61
29662647 2018
18
How to assess the best immunohistochemical panel in the diagnosis of malignant pleural mesothelioma in a pathology lab. 61
29757709 2018
19
Invasive sarcomatoid mesothelioma resulting in spinal cord compression: case report. 61
30363152 2018
20
Large primary pleural synovial sarcoma with severe dyspnea: a case report. 61
28205183 2017
21
The differential diagnosis between pleural sarcomatoid mesothelioma and spindle cell/pleomorphic (sarcomatoid) carcinomas of the lung: evidence-based guidelines from the International Mesothelioma Panel and the MESOPATH National Reference Center. 61
28782639 2017
22
Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma. 61
28915695 2017
23
[Clinical and pathologic features of extrapleural sarcomatoid mesothelioma]. 61
28810297 2017
24
Primary malignant pericardial sarcomatoid mesothelioma: An autopsy report. 61
28463437 2017
25
MUC4, a novel immunohistochemical marker identified by gene expression profiling, differentiates pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma. 61
28128276 2017
26
Apoptosis by [Pt(O,O'-acac)(γ-acac)(DMS)] requires PKC-δ mediated p53 activation in malignant pleural mesothelioma. 61
28704484 2017
27
Pathology reporting of malignant pleural mesothelioma first diagnosis: A population-based approach. 61
27485167 2016
28
Dual preventive benefits of iron elimination by desferal in asbestos-induced mesothelial carcinogenesis. 61
27088640 2016
29
Localized malignant pleural sarcomatoid mesothelioma misdiagnosed as benign localized fibrous tumor. 61
27293862 2016
30
[Clinical Pathological Diagnosis, and Treatment for Pleural Mesothelioma]. 61
27210080 2016
31
Sarcomatoid mesothelioma: future advances in diagnosis, biomolecular assessment, and therapeutic options in a poor-outcome disease. 61
26108245 2016
32
The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification. 61
26811225 2016
33
An immunohistochemical comparison of two TTF-1 monoclonal antibodies in atypical squamous lesions and sarcomatoid carcinoma of the lung, and pleural malignant mesothelioma. 61
26281863 2016
34
Sarcomatoid Type Primary Pericardial Mesothelioma with a Long-term Survival after the Onset of Cardiac Tamponade. 61
27803412 2016
35
Biphasic Malignant Pleural Mesothelioma Masquerading as a Primary Skeletal Tumor. 61
27660729 2016
36
Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma. 61
26870271 2016
37
Infant pleuropulmonary blastoma: report of a rare case and review of literature. 61
26722577 2015
38
FISH analysis of intrapulmonary malignant mesothelioma without a clinically detectable primary pleural lesion: an autopsy case. 61
25425731 2014
39
Reproducibility of histological subtyping of malignant pleural mesothelioma. 61
25300229 2014
40
Systematic review of response rates of sarcomatoid malignant pleural mesotheliomas in clinical trials. 61
25217189 2014
41
Connective tissue growth factor and β-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma. 61
24839947 2014
42
B7-H1 expression in malignant pleural mesothelioma is associated with sarcomatoid histology and poor prognosis. 61
24926549 2014
43
Antineoplastic activity of povidone-iodine on different mesothelioma cell lines: results of in vitro study. 61
24394552 2014
44
Phrenic nerve paralysis as the initial presentation in pleural sarcomatoid mesothelioma. 61
25076889 2014
45
AHNAK is highly expressed and plays a key role in cell migration and invasion in mesothelioma. 61
24253341 2014
46
Mesothelioma and anti-Ma paraneoplastic syndrome; heterogeneity in immunogenic tumours increases. 61
23749880 2014
47
[Peritoneal malignant mesothelioma: review and recent data]. 61
24630634 2014
48
Localized biphasic type malignant mesothelioma arising in the peritoneum: Report of a case. 61
26766976 2014
49
CD90 is a diagnostic marker to differentiate between malignant pleural mesothelioma and lung carcinoma with immunohistochemistry. 61
24045552 2013
50
Sarcomatoid mesothelioma with osteoid differentiation. 61
23945391 2013

Variations for Sarcomatoid Mesothelioma

Expression for Sarcomatoid Mesothelioma

Search GEO for disease gene expression data for Sarcomatoid Mesothelioma.

Pathways for Sarcomatoid Mesothelioma

Pathways related to Sarcomatoid Mesothelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.66 VIM PDPN MUC1 KRT5 DES BAP1
2
Show member pathways
11.37 VIM KRT5 DES
3 10.99 VIM DES ACTC1

GO Terms for Sarcomatoid Mesothelioma

Biological processes related to Sarcomatoid Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.55 WT1 VIM NKX2-1 CDKN2A ACTC1
2 intermediate filament organization GO:0045109 9.26 VIM DES
3 actin-mediated cell contraction GO:0070252 8.96 PDPN ACTC1
4 muscle filament sliding GO:0030049 8.8 VIM DES ACTC1

Molecular functions related to Sarcomatoid Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.8 VIM KRT5 DES

Sources for Sarcomatoid Mesothelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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