MCID: SRC001
MIFTS: 31

Sarcomatoid Mesothelioma

Categories: Cancer diseases

Aliases & Classifications for Sarcomatoid Mesothelioma

MalaCards integrated aliases for Sarcomatoid Mesothelioma:

Name: Sarcomatoid Mesothelioma 12 15 73
Malignant Fibrous Mesothelioma 12
Spindled Mesothelioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4488
NCIt 50 C45655
UMLS 73 C0334513

Summaries for Sarcomatoid Mesothelioma

MalaCards based summary : Sarcomatoid Mesothelioma, also known as malignant fibrous mesothelioma, is related to malignant epithelial mesothelioma and lymphohistiocytoid mesothelioma. An important gene associated with Sarcomatoid Mesothelioma is THBD (Thrombomodulin). The drugs Cisplatin and Vinblastine have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and testis, and related phenotype is respiratory system.

Related Diseases for Sarcomatoid Mesothelioma

Diseases related to Sarcomatoid Mesothelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 malignant epithelial mesothelioma 30.6 THBD WT1
2 lymphohistiocytoid mesothelioma 30.2 CDKN2A THBD
3 malignant pleural mesothelioma 28.9 MUC1 NKX2-1 THBD WT1
4 adenomatoid tumor 10.5 THBD WT1
5 malignant biphasic mesothelioma 10.5 THBD WT1
6 rete testis adenocarcinoma 10.5 NKX2-1 THBD
7 rete testis neoplasm 10.4 NKX2-1 THBD
8 ovarian brenner tumor 10.4 THBD WT1
9 endosalpingiosis 10.4 MUC1 WT1
10 ovarian small cell carcinoma 10.4 MUC1 WT1
11 desmoplastic small round cell tumor 10.4 MUC1 WT1
12 sertoli-leydig cell tumor 10.3 MUC1 WT1
13 solid adenocarcinoma with mucin production 10.3 MUC1 NKX2-1
14 sertoli cell tumor 10.3 MUC1 WT1
15 chordoid glioma 10.3 MUC1 NKX2-1
16 pericardial mesothelioma 10.3 MUC1 THBD
17 fallopian tube squamous cell carcinoma 10.3 CDKN2A WT1
18 rhabdoid cancer 10.3 MUC1 WT1
19 extraskeletal ewing sarcoma 10.3 MUC1 NKX2-1
20 melanomatosis 10.3 CDKN2A WT1
21 bile duct mucoepidermoid carcinoma 10.3 MUC1 MUC4
22 chronic ethmoiditis 10.3 MUC1 MUC4
23 sclerosing hemangioma 10.2 MUC1 NKX2-1
24 adenomyoma 10.2 MUC1 MUC4
25 breast giant fibroadenoma 10.2 CDKN2A WT1
26 papillary adenocarcinoma 10.2 MUC1 NKX2-1
27 filamentary keratitis 10.2 MUC1 MUC4
28 malignant ovarian surface epithelial-stromal neoplasm 10.2 MUC1 WT1
29 mucinous tubular and spindle renal cell carcinoma 10.2 MUC1 MUC4
30 ethmoid sinusitis 10.2 MUC1 MUC4
31 ovary epithelial cancer 10.2 MUC1 WT1
32 limbal stem cell deficiency 10.2 MUC1 MUC4
33 pleural cancer 10.2 CDKN2A WT1
34 diaphragmatic hernia, congenital 10.2 NKX2-1 WT1
35 breast secretory carcinoma 10.1 MUC1 MUC4
36 malignant peritoneal mesothelioma 10.1 CDKN2A MUC1
37 endometrial mucinous adenocarcinoma 10.1 CDKN2A MUC1
38 cholangiolocellular carcinoma 10.1 CDKN2A MUC1
39 pleomorphic liposarcoma 10.1 CDKN2A MUC1
40 cystadenoma 10.1 MUC1 MUC4
41 ischemic fasciitis 10.1 CDKN2A MUC1
42 colorectal cancer 1 10.1 MUC1 MUC4
43 well-differentiated liposarcoma 10.1 CDKN2A MUC1
44 sarcoma 10.1
45 dedifferentiated liposarcoma 10.1 CDKN2A MUC1
46 merkel cell carcinoma 10.1 MUC1 NKX2-1
47 plasmablastic lymphoma 10.1 CDKN2A MUC1
48 thymus cancer 10.0 MUC1 NKX2-1
49 meningeal melanocytoma 10.0 CDKN2A MUC1
50 dry eye syndrome 10.0 MUC1 MUC4

Graphical network of the top 20 diseases related to Sarcomatoid Mesothelioma:



Diseases related to Sarcomatoid Mesothelioma

Symptoms & Phenotypes for Sarcomatoid Mesothelioma

MGI Mouse Phenotypes related to Sarcomatoid Mesothelioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 8.92 CDKN2A NKX2-1 THBD WT1

Drugs & Therapeutics for Sarcomatoid Mesothelioma

Drugs for Sarcomatoid Mesothelioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2,Phase 1 15663-27-1 84093 441203 2767
2
Vinblastine Approved Phase 2 865-21-4 13342 241903
3
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
4
Vinorelbine Approved, Investigational Phase 2 71486-22-1 60780 44424639
5
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
6
Gemcitabine Approved Phase 2 95058-81-4 60750
7
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
8
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
9
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
10
Pemetrexed Approved, Investigational Phase 2,Phase 1 150399-23-8, 137281-23-3 446556 60843
11
Bevacizumab Approved, Investigational Phase 2 216974-75-3
12
Belinostat Approved, Investigational Phase 2 866323-14-0
13
Trioxsalen Approved Phase 2 3902-71-4 5585
14
Pembrolizumab Approved Phase 2 1374853-91-4
15
leucovorin Approved, Nutraceutical Phase 2,Phase 1 58-05-9 143 6006
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2,Phase 1 59-30-3 6037
17
Nicotinamide Approved, Investigational, Nutraceutical Phase 2 98-92-0 936
18
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
19
Glutamic Acid Approved, Nutraceutical Phase 1, Phase 2 56-86-0 33032
20
Vatalanib Investigational Phase 2 212141-54-3 151194
21
Cediranib Investigational Phase 2,Phase 1 288383-20-0 9933475
22
Maleic acid Experimental Phase 2,Phase 1 110-16-7 444266
23 Folic Acid Antagonists Phase 2,Phase 1
24 Dermatologic Agents Phase 2
25 Nucleic Acid Synthesis Inhibitors Phase 2,Phase 1
26 Vitamin B Complex Phase 2,Phase 1
27 Immunosuppressive Agents Phase 2
28 Antirheumatic Agents Phase 2
29 Antimetabolites Phase 2
30 Antimetabolites, Antineoplastic Phase 2
31 Antimitotic Agents Phase 2
32 Antineoplastic Agents, Phytogenic Phase 2
33 Ether Phase 2
34
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
35 Micronutrients Phase 2
36 Semaxinib Phase 2
37 Histone Deacetylase Inhibitors Phase 2
38 Nicotinic Acids Phase 2
39 Trace Elements Phase 2
40 Angiogenesis Inhibitors Phase 2
41 Dihematoporphyrin Ether Phase 2
42 Angiogenesis Modulating Agents Phase 2
43 Vitamins Phase 2
44 Antibodies Phase 2
45 Immunoglobulins Phase 2
46 Antibodies, Monoclonal Phase 2
47 Photosensitizing Agents Phase 2
48 Anti-Infective Agents Phase 2
49 Protein Kinase Inhibitors Phase 2,Phase 1
50 Antiviral Agents Phase 2

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Video-Assisted Surgery or Talc Pleurodesis in Treating Patients With Malignant Mesothelioma Completed NCT00821860 Phase 3
2 Combination Chemotherapy With or Without Surgery and Chemoradiotherapy in Treating Patients With Malignant Pleural Mesothelioma Unknown status NCT00354393 Phase 2 cisplatin;methotrexate;vinorelbine ditartrate
3 S9810: Gemcitabine Plus Cisplatin in Treating Patients With Malignant Mesothelioma of the Pleura That Cannot Be Removed by Surgery Completed NCT00003723 Phase 2 gemcitabine hydrochloride
4 PXD101 as Second-Line Therapy in Treating Patients With Malignant Mesothelioma of the Chest That Cannot Be Removed By Surgery Completed NCT00365053 Phase 2 belinostat
5 S0509 - AZD2171 in Treating Patients With Malignant Pleural Mesothelioma That Cannot Be Removed By Surgery Completed NCT00243074 Phase 2 cediranib maleate
6 Gefitinib in Treating Patients With Malignant Mesothelioma Completed NCT00025207 Phase 2 gefitinib
7 Erlotinib in Treating Patients With Malignant Mesothelioma of the Lung Completed NCT00039182 Phase 2 erlotinib hydrochloride
8 Pemetrexed Disodium and Cisplatin Followed By Surgery and Radiation Therapy in Treating Patients With Malignant Pleural Mesothelioma Completed NCT00227630 Phase 2 cisplatin;pemetrexed disodium
9 Dasatinib in Treating Patients With Previously Treated Malignant Mesothelioma Completed NCT00509041 Phase 2 dasatinib
10 SU5416 in Treating Patients With Malignant Mesothelioma Completed NCT00006014 Phase 2 semaxanib
11 Surgery and Photodynamic Therapy in Treating Patients With Malignant Mesothelioma Completed NCT00054002 Phase 2 porfimer sodium
12 PTK787/ZK 222584 in Treating Patients With Unresectable Malignant Mesothelioma Completed NCT00053885 Phase 2 PTK787/ZK 222584
13 Cediranib Maleate in Treating Patients With Malignant Mesothelioma That Cannot Be Removed By Surgery Completed NCT00309946 Phase 2 cediranib maleate
14 Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Malignant Mesothelioma Completed NCT00027703 Phase 2 gemcitabine hydrochloride;cisplatin
15 Capecitabine in Treating Patients With Malignant Mesothelioma Completed NCT00004183 Phase 2 capecitabine
16 Sorafenib Tosylate in Treating Patients With Malignant Mesothelioma. Completed NCT00107432 Phase 2 sorafenib tosylate
17 Pemetrexed Disodium and Cisplatin With or Without Cediranib Maleate in Treating Patients With Malignant Pleural Mesothelioma Active, not recruiting NCT01064648 Phase 1, Phase 2 Cediranib Maleate;Cisplatin;Pemetrexed Disodium
18 Pembrolizumab in Treating Patients With Malignant Mesothelioma Active, not recruiting NCT02399371 Phase 2
19 Pemetrexed Disodium/Observation in Treating Patients W/ Malignant Pleural Mesothelioma w/Out Progressive Disease After 1st Line Chemotherapy Active, not recruiting NCT01085630 Phase 2 pemetrexed disodium
20 Pemetrexed Disodium and Cisplatin Followed by Surgery With or Without Radiation Therapy in Treating Patients With Malignant Pleural Mesothelioma Active, not recruiting NCT00334594 Phase 2 Cisplatin;Pemetrexed
21 Tivantinib in Treating Patients With Previously Treated Malignant Mesothelioma Terminated NCT01861301 Phase 2 Tivantinib
22 AMG 102, Pemetrexed Disodium, and Cisplatin in Treating Patients With Malignant Pleural Mesothelioma Withdrawn NCT01105390 Phase 2 cisplatin;pemetrexed disodium
23 Biomarkers of Angiogenesis and Disease in Patients With Unresectable Malignant Mesothelioma Treated on Clinical Trial CALGB-30107 Active, not recruiting NCT00898547

Search NIH Clinical Center for Sarcomatoid Mesothelioma

Genetic Tests for Sarcomatoid Mesothelioma

Anatomical Context for Sarcomatoid Mesothelioma

MalaCards organs/tissues related to Sarcomatoid Mesothelioma:

41
Lung, Endothelial, Testis

Publications for Sarcomatoid Mesothelioma

Articles related to Sarcomatoid Mesothelioma:

(show all 27)
# Title Authors Year
1
Sarcomatoid mesothelioma of tunica vaginalis testis in the right scrotum of a dog. ( 29794371 )
2018
2
The differential diagnosis between pleural sarcomatoid mesothelioma and spindle cell/pleomorphic (sarcomatoid) carcinomas of the lung: evidence-based guidelines from the International Mesothelioma Panel and the MESOPATH National Reference Center. ( 28782639 )
2017
3
Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma. ( 28915695 )
2017
4
Primary malignant pericardial sarcomatoid mesothelioma: An autopsy report. ( 28463437 )
2017
5
MUC4, a novel immunohistochemical marker identified by gene expression profiling, differentiates pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma. ( 28128276 )
2017
6
Localized malignant pleural sarcomatoid mesothelioma misdiagnosed as benign localized fibrous tumor. ( 27293862 )
2016
7
Sarcomatoid mesothelioma: future advances in diagnosis, biomolecular assessment, and therapeutic options in a poor-outcomeA disease. ( 26108245 )
2015
8
Phrenic nerve paralysis as the initial presentation in pleural sarcomatoid mesothelioma. ( 25076889 )
2014
9
Connective tissue growth factor and I^-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma. ( 24839947 )
2014
10
Sarcomatoid mesothelioma with osteoid differentiation. ( 23945391 )
2013
11
Diagnostic usefulness of p16/CDKN2A FISH in distinguishing between sarcomatoid mesothelioma and fibrous pleuritis. ( 23270897 )
2013
12
Primary malignant sarcomatoid mesothelioma in the pericardium. ( 23318857 )
2013
13
The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma. ( 21255833 )
2011
14
Pleomorphic epithelioid diffuse malignant pleural mesothelioma: a clinicopathological review and conceptual proposal to reclassify as biphasic or sarcomatoid mesothelioma. ( 21358344 )
2011
15
Coarse pleural calcification in a mesothelioma patient raises the possibility of a rare tumour subtype: osteoblastic sarcomatoid mesothelioma. ( 21511743 )
2011
16
Sarcomatoid mesothelioma: a clinical-pathologic correlation of 326 cases. ( 20081811 )
2010
17
Value of immunohistochemistry in the differential diagnosis of pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma. ( 19438742 )
2009
18
Choroid plexus metastases from pleural sarcomatoid mesothelioma. ( 18604744 )
2008
19
Podoplanin is a better immunohistochemical marker for sarcomatoid mesothelioma than calretinin. ( 18162779 )
2008
20
Differential diagnosis of sarcomatoid mesothelioma from true sarcoma and sarcomatoid carcinoma using immunohistochemistry. ( 18199156 )
2008
21
SYT-SSX fusion is absent in sarcomatoid mesothelioma allowing its distinction from synovial sarcoma of the pleura. ( 17507990 )
2007
22
Subcutaneous metastases of sarcomatoid mesothelioma with its differential diagnosis on fine needle aspiration--a case report. ( 16366102 )
2005
23
Sarcomatoid mesothelioma and its histological mimics: a comparative immunohistochemical study. ( 12605647 )
2003
24
Anti-mesothelial markers in sarcomatoid mesothelioma and other spindle cell neoplasms. ( 10971698 )
2000
25
Malignant sarcomatoid mesothelioma of the pleura: a histological and immunohistological study of a case. ( 1923633 )
1991
26
Lymphohistiocytoid mesothelioma: a rare lymphomatoid variant of predominantly sarcomatoid mesothelioma. ( 2458647 )
1988
27
Three types of spindle cell tumors of the pleura. Fibroma, sarcoma, and sarcomatoid mesothelioma. ( 3421411 )
1988

Variations for Sarcomatoid Mesothelioma

Expression for Sarcomatoid Mesothelioma

Search GEO for disease gene expression data for Sarcomatoid Mesothelioma.

Pathways for Sarcomatoid Mesothelioma

GO Terms for Sarcomatoid Mesothelioma

Biological processes related to Sarcomatoid Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 O-glycan processing GO:0016266 8.62 MUC1 MUC4

Sources for Sarcomatoid Mesothelioma

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62 PubMed
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69 SNOMED-CT via HPO
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71 TGDB
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74 UMLS via Orphanet
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