MCID: SRC001
MIFTS: 31

Sarcomatoid Mesothelioma

Categories: Cancer diseases

Aliases & Classifications for Sarcomatoid Mesothelioma

MalaCards integrated aliases for Sarcomatoid Mesothelioma:

Name: Sarcomatoid Mesothelioma 12 15 17 70
Malignant Fibrous Mesothelioma 12
Spindled Mesothelioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4488
NCIt 50 C45655
SNOMED-CT 67 54443001
UMLS 70 C0334513

Summaries for Sarcomatoid Mesothelioma

MalaCards based summary : Sarcomatoid Mesothelioma, also known as malignant fibrous mesothelioma, is related to malignant epithelial mesothelioma and lymphohistiocytoid mesothelioma. An important gene associated with Sarcomatoid Mesothelioma is CALB2 (Calbindin 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Interleukin-4 and 13 signaling. Affiliated tissues include lung, ovary and liver, and related phenotypes are cardiovascular system and muscle

Related Diseases for Sarcomatoid Mesothelioma

Diseases related to Sarcomatoid Mesothelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)
# Related Disease Score Top Affiliating Genes
1 malignant epithelial mesothelioma 30.6 THBD CALB2
2 lymphohistiocytoid mesothelioma 30.3 THBD CDKN2A CALB2
3 pericardial mesothelioma 30.3 VIM MUC1 CALB2
4 lung sarcoma 30.2 NKX2-1 NAPSA CALB2
5 benign mesothelioma 30.2 WT1 VIM THBD PDPN NKX2-1 MSLN
6 rare tumor 30.1 DES ACTC1
7 fibrous histiocytoma 30.1 VIM DES ACTC1
8 benign peritoneal mesothelioma 30.0 WT1 PDPN MUC1 MSLN CALB2
9 malignant fibrous histiocytoma 29.8 VIM MUC1 DES ACTC1
10 adenocarcinoma 29.7 NKX2-1 NAPSA MUC4 MUC1 CDKN2A
11 asbestosis 29.7 WT1 THBD MUC1 MSLN CALB2
12 sarcoma, synovial 29.6 WT1 VIM MUC1 DES CALB2
13 peritoneal mesothelioma 29.6 WT1 THBD MUC1 CDKN2A CALB2 BAP1
14 spindle cell sarcoma 29.6 VIM MUC1 DES ACTC1
15 fibromatosis 29.6 VIM DES ACTC1
16 fibroma 29.4 VIM DES CALB2 ACTC1
17 malignant pleural mesothelioma 29.4 WT1 THBD PDPN NKX2-1 MUC1 MSLN
18 lung sarcomatoid carcinoma 29.2 THBD NKX2-1 NAPSA MUC4 MUC1 CEACAM3
19 leiomyosarcoma 28.9 WT1 VIM MUC1 DES CDKN2A ACTC1
20 wilms tumor 1 28.6 WT1 VIM PDPN NKX2-1 MUC1 DES
21 mesothelioma, malignant 28.5 WT1 VIM THBD PDPN NKX2-1 MUC1
22 fallopian tube carcinosarcoma 10.4 WT1 CALB2
23 epididymal neoplasm 10.4 WT1 CALB2
24 gynandroblastoma 10.4 VIM CALB2
25 nephrogenic adenoma of the urethra 10.4 THBD CALB2
26 ovarian endometrioid stromal sarcoma 10.4 WT1 CALB2
27 hobnail hemangioma 10.4 WT1 PDPN
28 juvenile type testicular granulosa cell tumor 10.4 WT1 CALB2
29 testicular granulosa cell tumor 10.4 WT1 CALB2
30 localized pulmonary fibrosis 10.4 PDPN MUC1
31 ovarian gonadoblastoma 10.4 WT1 CALB2
32 thyroid angiosarcoma 10.4 THBD NKX2-1
33 ovarian germ cell teratoma 10.4 NKX2-1 CALB2
34 mucinous stomach adenocarcinoma 10.4 NKX2-1 CALB2
35 fallopian tube squamous cell carcinoma 10.3 WT1 CDKN2A
36 esophageal adenoid cystic carcinoma 10.3 VIM PDPN
37 pancreatic mucinous cystadenoma 10.3 MUC1 CALB2
38 urethral benign neoplasm 10.3 THBD CALB2
39 ovarian sex-cord stromal tumor 10.3 WT1 CALB2
40 colonic lymphangioma 10.3 PDPN MUC1
41 papillary tumor of the pineal region 10.3 VIM MUC1
42 eccrine porocarcinoma 10.3 VIM MUC1
43 nodular hidradenoma 10.3 VIM MUC1
44 ovarian seromucinous carcinoma 10.3 WT1 CDKN2A
45 lymphangitis 10.3 PDPN NKX2-1
46 ovarian serous cystadenofibroma 10.3 MUC1 CALB2
47 bladder leiomyoma 10.3 VIM CALB2
48 supraglottis neoplasm 10.3 PDPN CDKN2A
49 laryngeal small cell carcinoma 10.3 NKX2-1 CDKN2A
50 gallbladder adenoma 10.3 PDPN CDKN2A

Graphical network of the top 20 diseases related to Sarcomatoid Mesothelioma:



Diseases related to Sarcomatoid Mesothelioma

Symptoms & Phenotypes for Sarcomatoid Mesothelioma

MGI Mouse Phenotypes related to Sarcomatoid Mesothelioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 ACTC1 BAP1 CDKN2A DES GATA3 NKX2-1
2 muscle MP:0005369 9.76 ACTC1 BAP1 CDKN2A DES GATA3 PDPN
3 normal MP:0002873 9.56 ACTC1 CALB2 GATA3 MSLN NKX2-1 THBD
4 respiratory system MP:0005388 9.17 BAP1 CDKN2A NKX2-1 PDPN THBD VIM

Drugs & Therapeutics for Sarcomatoid Mesothelioma

Search Clinical Trials , NIH Clinical Center for Sarcomatoid Mesothelioma

Genetic Tests for Sarcomatoid Mesothelioma

Anatomical Context for Sarcomatoid Mesothelioma

MalaCards organs/tissues related to Sarcomatoid Mesothelioma:

40
Lung, Ovary, Liver, Endothelial, Kidney, Spinal Cord, Uterus

Publications for Sarcomatoid Mesothelioma

Articles related to Sarcomatoid Mesothelioma:

(show top 50) (show all 121)
# Title Authors PMID Year
1
Utility of SOX6 and DAB2 for the Diagnosis of Malignant Mesothelioma. 61
33782226 2021
2
Utility of Immunohistochemistry for MUC4 and GATA3 to Aid in the Distinction of Pleural Sarcomatoid Mesothelioma From Pulmonary Sarcomatoid Carcinoma. 61
33501493 2021
3
Intermittent Superior Vena Cava Syndrome Secondary to Malignant Pericardial Mesothelioma. 61
33489524 2020
4
Sarcomatoid Mesothelioma: A CDKN2A molecular analysis of 53 cases with immunohistochemical correlation with BAP1. 61
33176261 2020
5
The potential utility of GATA binding protein 3 for diagnosis of malignant pleural mesotheliomas. 61
32888937 2020
6
Primary Intrathoracic Sarcomas: A Review of Cross-sectional Imaging and Pathology. 61
33196594 2020
7
Frequent expression of conventional endothelial markers in pleural mesothelioma: usefulness of claudin-5 as well as combined traditional markers to distinguish mesothelioma from angiosarcoma. 61
32777673 2020
8
ALPPL2 Is a Highly Specific and Targetable Tumor Cell Surface Antigen. 61
32868383 2020
9
Heterologous sarcomatoid pleural mesothelioma with osteosarcomatous differentiation: a report of autopsy case that accomplished trimodality therapy and review of the literature. 61
31372931 2020
10
Preliminary study highlights the potential of immune checkpoint inhibitors in sarcomatoid mesothelioma. 61
32676326 2020
11
Comprehensive Molecular and Pathologic Evaluation of Transitional Mesothelioma Assisted by Deep Learning Approach: A Multi-Institutional Study of the International Mesothelioma Panel from the MESOPATH Reference Center. 61
32165206 2020
12
Utility of Immunohistochemistry for MUC4 and GATA3 to Aid in the Distinction of Pleural Sarcomatoid Mesothelioma From Pulmonary Sarcomatoid Carcinoma. 61
32589069 2020
13
Overexpression of miR-199/214 is a distinctive feature of iron-induced and asbestos-induced sarcomatoid mesothelioma in rats. 61
32248600 2020
14
The YAP1 Signaling Inhibitors, Verteporfin and CA3, Suppress the Mesothelioma Cancer Stem Cell Phenotype. 61
31732616 2020
15
Pleural sarcomatoid mesothelioma with an interstitial growth pattern. 61
31898836 2020
16
Expression of V-set immunoregulatory receptor in malignant mesothelioma. 61
31363159 2020
17
Peritoneal sarcomatoid mesothelioma in a sika deer. 61
31413229 2019
18
Prostate Carcinoma and Pleural Mesothelioma: An Extremely Rare Co-occurrence. 61
31316876 2019
19
Revisiting localized malignant mesothelioma. 61
30798074 2019
20
Immunohistochemical evaluation of nuclear 5-hydroxymethylcytosine (5-hmC) accurately distinguishes malignant pleural mesothelioma from benign mesothelial proliferations. 61
30315275 2019
21
Impact on survival of nuclear atypia in epithelioid malignant mesothelioma. 61
31038719 2019
22
Is There a Role for Cancer-Directed Surgery in Early-Stage Sarcomatoid or Biphasic Mesothelioma? 61
30278171 2019
23
[Clinical and pathological profile of the pleural malignant mesothelioma: A retrospective study about 30 cases]. 61
30293912 2018
24
A combination of MTAP and BAP1 immunohistochemistry is effective for distinguishing sarcomatoid mesothelioma from fibrous pleuritis. 61
30429020 2018
25
Highlights of the 14th international mesothelioma interest group meeting: Pathologic separation of benign from malignant mesothelial proliferations and histologic/molecular analysis of malignant mesothelioma subtypes. 61
30268487 2018
26
Sarcomatoid mesothelioma of tunica vaginalis testis in the right scrotum of a dog. 61
29794371 2018
27
Characterization of increasing stages of invasiveness identifies stromal/cancer cell crosstalk in rat models of mesothelioma. 61
29662647 2018
28
How to assess the best immunohistochemical panel in the diagnosis of malignant pleural mesothelioma in a pathology lab. 61
29757709 2018
29
Invasive sarcomatoid mesothelioma resulting in spinal cord compression: case report. 61
30363152 2018
30
Large primary pleural synovial sarcoma with severe dyspnea: a case report. 61
28205183 2017
31
The differential diagnosis between pleural sarcomatoid mesothelioma and spindle cell/pleomorphic (sarcomatoid) carcinomas of the lung: evidence-based guidelines from the International Mesothelioma Panel and the MESOPATH National Reference Center. 61
28782639 2017
32
[Clinical and pathologic features of extrapleural sarcomatoid mesothelioma]. 61
28810297 2017
33
Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma. 61
28915695 2017
34
Primary malignant pericardial sarcomatoid mesothelioma: An autopsy report. 61
28463437 2017
35
MUC4, a novel immunohistochemical marker identified by gene expression profiling, differentiates pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma. 61
28128276 2017
36
Apoptosis by [Pt(O,O'-acac)(γ-acac)(DMS)] requires PKC-δ mediated p53 activation in malignant pleural mesothelioma. 61
28704484 2017
37
Pathology reporting of malignant pleural mesothelioma first diagnosis: A population-based approach. 61
27485167 2016
38
Dual preventive benefits of iron elimination by desferal in asbestos-induced mesothelial carcinogenesis. 61
27088640 2016
39
Localized malignant pleural sarcomatoid mesothelioma misdiagnosed as benign localized fibrous tumor. 61
27293862 2016
40
[Clinical Pathological Diagnosis, and Treatment for Pleural Mesothelioma]. 61
27210080 2016
41
Sarcomatoid mesothelioma: future advances in diagnosis, biomolecular assessment, and therapeutic options in a poor-outcome disease. 61
26108245 2016
42
The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification. 61
26811225 2016
43
An immunohistochemical comparison of two TTF-1 monoclonal antibodies in atypical squamous lesions and sarcomatoid carcinoma of the lung, and pleural malignant mesothelioma. 61
26281863 2016
44
Biphasic Malignant Pleural Mesothelioma Masquerading as a Primary Skeletal Tumor. 61
27660729 2016
45
Sarcomatoid Type Primary Pericardial Mesothelioma with a Long-term Survival after the Onset of Cardiac Tamponade. 61
27803412 2016
46
Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma. 61
26870271 2016
47
Infant pleuropulmonary blastoma: report of a rare case and review of literature. 61
26722577 2015
48
FISH analysis of intrapulmonary malignant mesothelioma without a clinically detectable primary pleural lesion: an autopsy case. 61
25425731 2014
49
Reproducibility of histological subtyping of malignant pleural mesothelioma. 61
25300229 2014
50
Systematic review of response rates of sarcomatoid malignant pleural mesotheliomas in clinical trials. 61
25217189 2014

Variations for Sarcomatoid Mesothelioma

Expression for Sarcomatoid Mesothelioma

Search GEO for disease gene expression data for Sarcomatoid Mesothelioma.

Pathways for Sarcomatoid Mesothelioma

Pathways related to Sarcomatoid Mesothelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.59 VIM PDPN MUC1 DES BAP1 ACTC1
2 11.39 VIM MUC1 GATA3
3 10.99 VIM DES ACTC1

GO Terms for Sarcomatoid Mesothelioma

Biological processes related to Sarcomatoid Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.72 WT1 NKX2-1 GATA3 CDKN2A BAP1
2 negative regulation of cell proliferation GO:0008285 9.55 WT1 PDPN GATA3 CDKN2A BAP1
3 intermediate filament organization GO:0045109 9.4 VIM DES
4 anatomical structure formation involved in morphogenesis GO:0048646 9.37 NKX2-1 GATA3
5 mesenchymal to epithelial transition GO:0060231 9.26 WT1 GATA3
6 muscle filament sliding GO:0030049 9.13 VIM DES ACTC1
7 positive regulation of gene expression GO:0010628 9.1 WT1 VIM NKX2-1 GATA3 CDKN2A ACTC1

Sources for Sarcomatoid Mesothelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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