MCID: SRC002
MIFTS: 43

Sarcomatoid Renal Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Sarcomatoid Renal Cell Carcinoma

MalaCards integrated aliases for Sarcomatoid Renal Cell Carcinoma:

Name: Sarcomatoid Renal Cell Carcinoma 12 15 73
Renal Cell Carcinoma, Spindle Cell 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4473
MeSH 44 D002292
NCIt 50 C27893
SNOMED-CT 68 128668003
UMLS 73 C1266043

Summaries for Sarcomatoid Renal Cell Carcinoma

MalaCards based summary : Sarcomatoid Renal Cell Carcinoma, also known as renal cell carcinoma, spindle cell, is related to renal cell carcinoma, nonpapillary and oncocytoma, and has symptoms including flank pain An important gene associated with Sarcomatoid Renal Cell Carcinoma is PAX8 (Paired Box 8), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs nivolumab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Sarcomatoid Renal Cell Carcinoma

Diseases related to Sarcomatoid Renal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 renal cell carcinoma, nonpapillary 30.2 IFNA2 KIT MUC1 PAX8
2 oncocytoma 30.2 KIT MUC1
3 sarcoma, synovial 29.9 KIT MUC1
4 spindle cell thymoma 10.6 MUC1 PAX8
5 endosalpingiosis 10.6 MUC1 PAX8
6 nephrogenic adenoma 10.5 MUC1 PAX8
7 malignant mixed mullerian tumor 10.5 KIT MUC1
8 aggressive digital papillary adenocarcinoma 10.5 KIT MUC1
9 perivascular epithelioid cell tumor 10.5 KIT MUC1
10 mixed type thymoma 10.5 KIT PAX8
11 perineurioma 10.4 KIT MUC1
12 dermoid cyst 10.4 KIT MUC1
13 kidney benign neoplasm 10.4 KIT PAX8
14 malignant ovarian surface epithelial-stromal neoplasm 10.4 MUC1 PAX8
15 polymorphous low-grade adenocarcinoma 10.4 KIT MUC1
16 ovary epithelial cancer 10.4 MUC1 PAX8
17 rete testis neoplasm 10.4 KIT PAX8
18 water-clear cell adenoma 10.4 GATA3 PAX8
19 cavernous hemangioma 10.4 KIT MUC1
20 angiosarcoma 10.3 KIT MUC1
21 merkel cell carcinoma 10.2 KIT MUC1
22 chronic orbital inflammation 10.2 IFNA2 MUC1
23 aggressive systemic mastocytosis 10.2 IFNA2 KIT
24 thymus cancer 10.1 KIT MUC1
25 malignant skin fibrous histiocytoma 10.1 IFNA2 KIT
26 malignant dermis tumor 10.1 IFNA2 KIT
27 thrombocytopenic purpura, autoimmune 10.0 GATA3 IFNA2
28 sarcoma 10.0
29 sm-ahnmd 10.0 KIT PDGFRA
30 gastric leiomyosarcoma 10.0 KIT PDGFRA
31 desmoid tumor 9.9 KIT PDGFRA
32 conventional fibrosarcoma 9.9 KIT PDGFRA
33 endometrial small cell carcinoma 9.9 KIT PDGFRA
34 pulmonary vein stenosis 9.9 KIT PDGFRA
35 hypereosinophilic syndrome, idiopathic 9.9 KIT PDGFRA
36 undifferentiated pleomorphic sarcoma 9.9 KIT PDGFRA
37 renal cell carcinoma, papillary, 1 9.9 KIT PAX8
38 lung adenoid cystic carcinoma 9.9 KIT PDGFRA
39 carney triad 9.9 KIT PDGFRA
40 heart sarcoma 9.9 KIT PDGFRA
41 chronic eosinophilic leukemia 9.9 KIT PDGFRA
42 mesenchymal cell neoplasm 9.9 KIT PDGFRA
43 neurofibromatosis, type i 9.9 KIT PDGFRA
44 ovarian brenner tumor 9.9 GATA3 KIT PAX8
45 fibrosarcoma of bone 9.8 KIT PDGFRA
46 schistosomiasis 9.8
47 cystic kidney disease 9.8
48 collecting duct carcinoma 9.8
49 urinary tract obstruction 9.8
50 kidney disease 9.8

Graphical network of the top 20 diseases related to Sarcomatoid Renal Cell Carcinoma:



Diseases related to Sarcomatoid Renal Cell Carcinoma

Symptoms & Phenotypes for Sarcomatoid Renal Cell Carcinoma

UMLS symptoms related to Sarcomatoid Renal Cell Carcinoma:


flank pain

GenomeRNAi Phenotypes related to Sarcomatoid Renal Cell Carcinoma according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.47 JUP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.47 PDGFRA
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-150 9.47 JUP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.47 KIT
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.47 PDGFRA
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.47 JUP KIT PDGFRA
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.47 JUP
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.47 PDGFRA
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.47 KIT
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.47 JUP
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.47 PDGFRA
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.47 PDGFRA

MGI Mouse Phenotypes related to Sarcomatoid Renal Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.46 KIT PAX8 PDGFRA GATA3
2 embryo MP:0005380 9.35 KIT PAX8 PDGFRA GATA3 JUP
3 normal MP:0002873 9.02 JUP KIT PAX8 PDGFRA GATA3

Drugs & Therapeutics for Sarcomatoid Renal Cell Carcinoma

Drugs for Sarcomatoid Renal Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 3,Phase 2 946414-94-4
2 Antibodies Phase 3,Phase 2
3 Immunoglobulins Phase 3,Phase 2
4 Antibodies, Monoclonal Phase 3,Phase 2
5
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
6
Gemcitabine Approved Phase 2 95058-81-4 60750
7
Lenograstim Approved, Investigational Phase 2 135968-09-1
8
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
9
Sorafenib Approved, Investigational Phase 1, Phase 2 284461-73-0 216239 406563
10
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
11
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
12
Nicotinamide Approved, Investigational, Nutraceutical Phase 1, Phase 2,Phase 2 98-92-0 936
13
Niacin Approved, Investigational, Nutraceutical Phase 1, Phase 2,Phase 2 59-67-6 938
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
15
Doxil Approved June 1999 Phase 2 31703
16 Adjuvants, Immunologic Phase 2
17 Micronutrients Phase 1, Phase 2
18 Mitogens Phase 2
19 Nicotinic Acids Phase 1, Phase 2
20 Topoisomerase Inhibitors Phase 2
21 Trace Elements Phase 1, Phase 2
22 Angiogenesis Inhibitors Phase 2,Phase 1
23 Angiogenesis Modulating Agents Phase 2,Phase 1
24 Endothelial Growth Factors Phase 2
25 Anti-Bacterial Agents Phase 2
26 Vitamin B Complex Phase 1, Phase 2
27 Antibiotics, Antitubercular Phase 2
28 Vitamins Phase 1, Phase 2
29 Immunosuppressive Agents Phase 2
30 Anti-Infective Agents Phase 2
31 Protein Kinase Inhibitors Phase 1, Phase 2
32 Antimetabolites Phase 2
33 Antiviral Agents Phase 2
34 Antimetabolites, Antineoplastic Phase 2
35 Pharmaceutical Solutions Phase 2
36 Folate Nutraceutical Phase 1, Phase 2
37 Vitamin B3 Nutraceutical Phase 1, Phase 2
38 Vitamin B9 Nutraceutical Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab in Treating Patients With Localized Kidney Cancer Undergoing Nephrectomy Recruiting NCT03055013 Phase 3
2 Capecitabine, Gemcitabine, and Bevacizumab in Combination for Patients With Sarcomatoid Renal Cell Carcinoma Completed NCT00496587 Phase 2 Capecitabine;Gemcitabine;Bevacizumab
3 Doxorubicin and Gemcitabine in Treating Patients With Locally Recurrent or Metastatic Unresectable Renal Cell Carcinoma Completed NCT00068393 Phase 2 Doxorubicin;Gemcitabine;G-CSF (granulocyte-colony stimulating factor);Neulasta
4 Sorafenib Tosylate and Bevacizumab in Treating Patients With Advanced Kidney Cancer Completed NCT00126503 Phase 1, Phase 2 Sorafenib Tosylate
5 Phase II Sequential Treatment Trial of Single Agent Nivolumab, Then Combination Ipilimumab + Nivolumab in Metastatic or Unresectable Non-Clear Cell Renal Cell Carcinoma (ANZUP1602) Recruiting NCT03177239 Phase 2 Nivolumab;Ipilimumab
6 Sunitinib Malate With or Without Gemcitabine Hydrochloride in Treating Patients With Advanced Kidney Cancer That Cannot Be Removed By Surgery Active, not recruiting NCT01164228 Phase 2 gemcitabine hydrochloride;sunitinib malate
7 Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer Active, not recruiting NCT01767636 Phase 2 Pazopanib Hydrochloride

Search NIH Clinical Center for Sarcomatoid Renal Cell Carcinoma

Genetic Tests for Sarcomatoid Renal Cell Carcinoma

Anatomical Context for Sarcomatoid Renal Cell Carcinoma

MalaCards organs/tissues related to Sarcomatoid Renal Cell Carcinoma:

41
Kidney, Endothelial, Bone, Liver, Lung, Colon, Heart

Publications for Sarcomatoid Renal Cell Carcinoma

Articles related to Sarcomatoid Renal Cell Carcinoma:

(show top 50) (show all 122)
# Title Authors Year
1
Extensive Metastatic Sarcomatoid Renal Cell Carcinoma Evaluated by<sup>18</sup>F-FDG PET/CT: a Case Report and Review of Literature. ( 29354391 )
2018
2
Complete Response of a Patient With Metastatic Sarcomatoid Renal Cell Carcinoma to a Programmed Death-1 Checkpoint Inhibitor. ( 29920137 )
2018
3
Sarcomatoid renal cell carcinoma: Biology and treatment advances. ( 29306556 )
2018
4
Sarcomatoid renal cell carcinoma: a case report and literature review. ( 29636020 )
2018
5
Rapid recurrence and radiographic progression of sarcomatoid renal cell carcinoma. ( 29034177 )
2018
6
Duodenal metastases from sarcomatoid renal cell carcinoma: Case report. ( 27506336 )
2017
7
Sarcomatoid Renal Cell Carcinoma and Collecting Duct Carcinoma: Discrimination From Common Renal Cell Carcinoma Subtypes and Benign RCC Mimics on Multiphasic MDCT. ( 28528853 )
2017
8
Sarcomatoid Renal Cell Carcinoma: The Apple Doesn't Fall Far From the Tree. ( 28912138 )
2017
9
Phase 2 Trial of Capecitabine, Gemcitabine, and Bevacizumab in Sarcomatoid Renal-Cell Carcinoma. ( 28870517 )
2017
10
The Pathology and Molecular Genetics of Sarcomatoid Renal Cell Carcinoma: A Mini-Review. ( 28725540 )
2017
11
Metastatic sarcomatoid renal cell carcinoma manifesting as a subcutaneous soft tissue mass. ( 28675457 )
2017
12
Sarcomatoid renal cell carcinoma has a distinct molecular pathogenesis, driver mutation profile and transcriptional landscape. ( 28710314 )
2017
13
Immune Check Point Inhibition in Sarcomatoid Renal Cell Carcinoma: A New Treatment Paradigm. ( 28645484 )
2017
14
Sarcomatoid Renal Cell Carcinoma in an Adolescent with Sickle Cell Anaemia. ( 29225982 )
2017
15
Treatments, Outcomes, and Validity of Prognostic Scores in Patients With Sarcomatoid Renal Cell Carcinoma: A 20-Year Single-Institution Experience. ( 29395949 )
2017
16
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components. ( 29167760 )
2016
17
Prognostic value of preoperative inflammatory response biomarkers in patients with sarcomatoid renal cell carcinoma and the establishment of a nomogram. ( 27035802 )
2016
18
Radiographic Kinetics of Sarcomatoid Renal Cell Carcinoma. ( 27041470 )
2016
19
Rapidly Growing Right Ventricular Outflow Tract Mass in Patient with Sarcomatoid Renal Cell Carcinoma. ( 28090262 )
2016
20
Outcome of patients with metastatic sarcomatoid renal cell carcinoma: results from the international metastatic renal cell carcinoma database consortium. ( 25450036 )
2015
21
Sarcomatoid Renal Cell Carcinoma Metastasis to the Penis. ( 26257975 )
2015
22
Long-term survival following multidisciplinary treatment of metastatic sarcomatoid renal cell carcinoma: a case report. ( 26582158 )
2015
23
Does postoperative radiation therapy impact survival in non-metastatic sarcomatoid renal cell carcinoma? A SEER-based study. ( 26329746 )
2015
24
Diagnosis of Sarcomatoid Renal Cell Carcinoma With CT: Evaluation by Qualitative Imaging Features and Texture Analysis. ( 25905936 )
2015
25
Clinicopathologic characteristics and prognostic factors of sarcomatoid renal cell carcinoma. ( 25178995 )
2014
26
Leukemoid reaction in sarcomatoid renal cell carcinoma: a two-case report. ( 24745762 )
2014
27
A novel prognostic model for patients with sarcomatoid renal cell carcinoma. ( 24730416 )
2014
28
Sarcomatoid renal cell carcinoma: case report and review of literature. ( 25177568 )
2014
29
Successful mammalian target of rapamycin inhibitor maintenance therapy following induction chemotherapy with gemcitabine and doxorubicin for metastatic sarcomatoid renal cell carcinoma. ( 24959297 )
2014
30
Sarcomatoid renal cell carcinoma: clinical outcome and survival after treatment with sunitinib. ( 24560086 )
2014
31
A 78-year-old man with rapidly-progressing sarcomatoid renal cell carcinoma. ( 23923252 )
2013
32
Use of PAX8 and GATA3 in diagnosing sarcomatoid renal cell carcinoma and sarcomatoid urothelial carcinoma. ( 23453625 )
2013
33
Curability of poor-risk metastatic sarcomatoid renal cell carcinoma with the combination of gemcitabine, 5-fluorouracil, and interferon-alfa: a case report of a 55-year-old man with a 10-year complete remission. ( 23665133 )
2013
34
Sarcomatoid renal cell carcinoma with rhabdoid features. ( 24188946 )
2013
35
Characteristic MRI findings of sarcomatoid renal cell carcinoma dedifferentiated from clear cell renal carcinoma: radiological-pathological correlation. ( 23834905 )
2013
36
Sarcomatoid renal cell carcinoma with scant epithelial components in an Angora cat. ( 23600482 )
2013
37
Clinical outcome in patients receiving systemic therapy for metastatic sarcomatoid renal cell carcinoma: a retrospective analysis. ( 22608544 )
2013
38
Sarcomatoid renal cell carcinoma. ( 22704447 )
2012
39
Sarcomatoid renal cell carcinoma: a case report and literature review. ( 22690291 )
2012
40
Sarcomatoid renal cell carcinoma: a comprehensive review of the biology and current treatment strategies. ( 22234634 )
2012
41
Impact of pathological tumour characteristics in patients with sarcomatoid renal cell carcinoma. ( 22221668 )
2012
42
Combination of gemcitabine and doxorubicin in rapidly progressive metastatic renal cell carcinoma and/or sarcomatoid renal cell carcinoma. ( 21720184 )
2011
43
Systemic therapy for sarcomatoid renal cell carcinoma. ( 21707288 )
2011
44
Sarcomatoid renal cell carcinoma. ( 21196626 )
2011
45
A 51-year-old man with rapidly progressive metastatic sarcomatoid renal cell carcinoma: an apparent complete clinical response to second-line therapy with sunitinib and low-dose interferon-alpha. ( 21326149 )
2011
46
Sarcomatoid renal cell carcinoma is an example of epithelial--mesenchymal transition. ( 22003062 )
2011
47
Hydrocele: an atypical presentation of metastatic sarcomatoid renal cell carcinoma. ( 21703053 )
2011
48
Pathologic significance and prognostic value of phosphorylated cortactin expression in patients with sarcomatoid renal cell carcinoma. ( 21696810 )
2011
49
A progesterone-receptor-positive huge retroperitoneal tumour mimics metastasis in a breast cancer patient: sarcomatoid renal cell carcinoma. ( 21618856 )
2011
50
MRI findings of sarcomatoid renal cell carcinoma in nine cases. ( 22040791 )
2011

Variations for Sarcomatoid Renal Cell Carcinoma

Expression for Sarcomatoid Renal Cell Carcinoma

Search GEO for disease gene expression data for Sarcomatoid Renal Cell Carcinoma.

Pathways for Sarcomatoid Renal Cell Carcinoma

GO Terms for Sarcomatoid Renal Cell Carcinoma

Cellular components related to Sarcomatoid Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic side of plasma membrane GO:0009898 8.62 JUP KIT

Biological processes related to Sarcomatoid Renal Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.63 GATA3 KIT PDGFRA
2 positive regulation of kinase activity GO:0033674 9.59 KIT PDGFRA
3 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.58 KIT PDGFRA
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 IFNA2 KIT
5 anatomical structure morphogenesis GO:0009653 9.58 GATA3 PAX8 PDGFRA
6 inner ear morphogenesis GO:0042472 9.57 GATA3 PAX8
7 humoral immune response GO:0006959 9.56 GATA3 IFNA2
8 erythrocyte differentiation GO:0030218 9.55 GATA3 KIT
9 digestive tract development GO:0048565 9.54 GATA3 KIT
10 T cell differentiation GO:0030217 9.52 GATA3 KIT
11 ventricular septum development GO:0003281 9.51 GATA3 PAX8
12 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.49 KIT PDGFRA
13 cell activation GO:0001775 9.48 GATA3 PDGFRA
14 cytokine-mediated signaling pathway GO:0019221 9.46 GATA3 IFNA2 KIT MUC1
15 embryonic hemopoiesis GO:0035162 9.43 GATA3 KIT
16 mesonephros development GO:0001823 9.37 GATA3 PAX8
17 positive regulation of phospholipase C activity GO:0010863 9.32 KIT PDGFRA
18 otic vesicle development GO:0071599 9.26 GATA3 PAX8
19 positive regulation of thyroid hormone generation GO:2000611 8.96 GATA3 PAX8
20 mast cell differentiation GO:0060374 8.62 GATA3 KIT

Molecular functions related to Sarcomatoid Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.33 GATA3 MUC1 PAX8
2 mitogen-activated protein kinase kinase binding GO:0031434 9.32 KIT PDGFRA
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.26 KIT PDGFRA
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.96 KIT PDGFRA
5 growth factor binding GO:0019838 8.62 KIT PDGFRA

Sources for Sarcomatoid Renal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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