Sarcomatoid Renal Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SRC002 MIFTS: 38	Sarcomatoid Renal Cell Carcinoma Categories: Cancer diseases, Nephrological diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Sarcomatoid Renal Cell Carcinoma

MalaCards integrated aliases for Sarcomatoid Renal Cell Carcinoma:

Name: Sarcomatoid Renal Cell Carcinoma ¹² ¹⁵ ⁷¹

Renal Cell Carcinoma, Spindle Cell ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Nephrological diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4473

MeSH ⁴³ D002292

NCIt ⁴⁹ C27893

SNOMED-CT ⁶⁷ 128668003

UMLS ⁷¹ C1266043

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Summaries for Sarcomatoid Renal Cell Carcinoma

MalaCards based summary : Sarcomatoid Renal Cell Carcinoma, also known as renal cell carcinoma, spindle cell, is related to malignant fibrous histiocytoma and embryonal sarcoma, and has symptoms including flank pain An important gene associated with Sarcomatoid Renal Cell Carcinoma is PAX8 (Paired Box 8), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Gastric cancer. The drugs Gemcitabine and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and bone, and related phenotypes are digestive/alimentary and muscle

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Related Diseases for Sarcomatoid Renal Cell Carcinoma

Diseases related to Sarcomatoid Renal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 272)

#	Related Disease	Score	Top Affiliating Genes
1	malignant fibrous histiocytoma	30.7	TP53 MUC1 KIT
2	embryonal sarcoma	30.4	TP53 KIT
3	chromophobe renal cell carcinoma	30.3	S100A1 MUC1 KIT
4	leiomyosarcoma	30.2	TP53 S100A1 MUC1 KIT
5	cystitis	30.1	TP53 KIT CDH1
6	rhabdoid tumor predisposition syndrome 1	30.1	TP53 MUC1
7	papillary carcinoma	30.0	S100A1 PAX8 MUC1 CDH1
8	kidney cancer	29.9	TP53 PTEN IFNA2 CA9
9	fibrosarcoma	29.9	TP53 SSX2 KIT CA9
10	sarcoma, synovial	29.6	SSX2 MUC1 KIT CDH1
11	rhabdomyosarcoma	29.6	TP53 SSX2 PTEN KIT
12	clear cell renal cell carcinoma	29.6	TP53 PTEN PAX8 MUC1 CDH1 CA9
13	adenocarcinoma	29.3	TP53 PTEN MUC1 KIT CDH1
14	renal cell carcinoma, nonpapillary	29.3	TP53 S100A1 PTEN PAX8 MUC1 KIT
15	gastrointestinal stromal tumor	29.3	TP53 S100A1 PTEN KIT CDH1
16	sarcoma	29.0	TP53 SSX2 S100A1 MUC1 KIT IFNA2
17	dedifferentiated liposarcoma	28.9	TP53 SSX2 S100A1 PTEN MUC1 KIT
18	carcinosarcoma	28.7	TP53 S100A1 PTEN PAX8 MUC1 KIT
19	renal cell carcinoma, papillary, 1	28.7	TP53 S100A1 PTEN PAX8 KIT CDH1
20	bladder cancer	27.7	TP53 PTEN MUC1 IFNA2 CGB3 CDH1
21	ischemic fasciitis	10.5	S100A1 MUC1
22	papillary tumor of the pineal region	10.5	S100A1 MUC1
23	clear cell adenoma	10.5	S100A1 PAX8
24	reticular perineurioma	10.4	MUC1 KIT
25	intraneural perineurioma	10.4	S100A1 MUC1
26	axillary lipoma	10.4	MUC1 KIT
27	chondroid chordoma	10.4	S100A1 MUC1
28	krukenberg carcinoma	10.4	PAX8 MUC1
29	parachordoma	10.4	S100A1 MUC1
30	reticulum cell sarcoma	10.4	S100A1 MUC1
31	pericardial mesothelioma	10.4	S100A1 MUC1
32	pancreatic foamy gland adenocarcinoma	10.4	TP53 MUC1
33	cystadenofibroma	10.4	PAX8 MUC1
34	bile duct mucinous adenocarcinoma	10.4	TP53 MUC1
35	chordoid meningioma	10.4	S100A1 MUC1
36	colon leiomyosarcoma	10.4	PAX8 KIT
37	ossifying fibromyxoid tumor	10.4	S100A1 MUC1
38	ovarian seromucinous carcinoma	10.4	TP53 PAX8
39	ovarian mixed germ cell neoplasm	10.4	PAX8 KIT
40	glandular cystitis	10.4	TP53 MUC1
41	gallbladder signet ring cell adenocarcinoma	10.4	MUC1 CDH1
42	biliary tract benign neoplasm	10.4	TP53 MUC1
43	tumor of exocrine pancreas	10.4	TP53 MUC1
44	intratubular embryonal carcinoma	10.3	TP53 KIT
45	suppressor of tumorigenicity 3	10.3	TP53 CA9
46	renal pelvis adenocarcinoma	10.3	PAX8 CDH1
47	spindle cell carcinoma	10.3
48	ovarian serous cystadenofibroma	10.3	TP53 MUC1
49	breast malignant phyllodes tumor	10.3	TP53 KIT
50	linitis plastica	10.3	MUC1 CDH1

Graphical network of the top 20 diseases related to Sarcomatoid Renal Cell Carcinoma:

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Symptoms & Phenotypes for Sarcomatoid Renal Cell Carcinoma

UMLS symptoms related to Sarcomatoid Renal Cell Carcinoma:

flank pain

MGI Mouse Phenotypes related to Sarcomatoid Renal Cell Carcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.7	CA9 CDH1 GATA3 KIT PTEN RELN
2	muscle	MP:0005369	9.43	GATA3 KIT PTEN RELN S100A1 TP53
3	normal	MP:0002873	9.17	CDH1 GATA3 KIT PAX8 PTEN S100A1

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Drugs & Therapeutics for Sarcomatoid Renal Cell Carcinoma

Drugs for Sarcomatoid Renal Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Gemcitabine

Approved

Phase 2

95058-81-4

60750

Synonyms:

103882-84-4

122111-03-9

2',2'-DFDC

2',2'-DiF-dC

2',2'-difluoro-2'-Deoxycytidine

2',2'-Difluoro-2'-deoxycytidine

2',2'-Difluorodeoxycytidine

2'-Deoxy-.beta.-D-2',2'-difluorocytidine

2'-Deoxy-2',2'-difluorocytidine

2'-Deoxy-2',2''-difluorocytidine-5'-O-monophosphate

2'-Deoxy-2'-difluorocytidine

4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

4-amino-1-((2R,4R,5R)-3,3-difluoro-4-Hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-pyrimidin-2-one

95058-81-4

AB1004842

AC1L1TUQ

C07650

CCRIS 8984

CHEBI:175901

CHEMBL888

CID60750

Cytidine, 2'-deoxy-2',2'-difluoro-2'-Deoxy-.beta.-D-2',2'-difluorocytidine

D02368

DB00441

DDFC

DFdC

DFDC

DFdCyd

Folfugem

Gamcitabine

Gemcel

Gemcin

Gemcitabin

Gemcitabina

Gemcitabina [INN-Spanish]

gemcitabine

Gemcitabine

Gemcitabine (USAN/INN)

Gemcitabine HCl

Gemcitabine hydrochloride

Gemcitabine stereoisomer

Gemcitabine, (alpha-D-threo-pentofuranosyl)-isomer

Gemcitabine, (beta-D-threo-pentafuranosyl)-isomer

Gemcitabine, (D-threo-pentafuranosyl)-isomer

Gemcitabinum

Gemcitabinum [INN-Latin]

GemLip

Gemtro

Gemzar

Gemzar (hydrochloride)

GEO

HMS2089P10

HSDB 7567

Inno-D07001

LS-59139

LY 188011

LY188011

LY-188011

NCGC00168784-01

NChemBio.2007.10-comp25

nchembio.573-comp7

nchembio.90-comp2

NSC 613327

NSC613327

TL8005979

UNII-B76N6SBZ8R

Zefei

ZINC18279854

Bevacizumab

Approved, Investigational

Phase 2

216974-75-3

Synonyms:

216974-75-3

antiVEGF

Anti-VEGF Humanized Monoclonal Antibody

anti-VEGF monoclonal antibody

Anti-VEGF monoclonal antibody

Avastin

Avastin (TN)

bevacizumab

Bevacizumab

Bevacizumab (genetical recombination)

Bevacizumab (genetical recombination) (JAN)

bevacizumab-awwb

D06409

R-435

rhuMAb-VEGF

Capecitabine

Approved, Investigational

Phase 2

154361-50-9

60953

Synonyms:

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

154361-50-9

158798-73-3

5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine

5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine

AC1L1U83

AC1Q4KU8

Ambap154361-50-9

C110904

C12650

C15H22FN3O6

CAPE

Capecitabin

capecitabina

Capecitabina

capecitabine

Capecitabine

CAPECITABINE

Capécitabine

Capecitabine (JAN/USAN/INN)

Capecitabine [USAN]

capecitabinum

Capecitabinum

Capecitibine

Capiibine

Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester

Caxeta

CHEBI:31348

CHEMBL1773

CID60953

D01223

DB01101

FT-0082472

HSDB 7656

LS-59070

MolPort-005-938-254

N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate

R340

R-340

RG-340

Ro 09-1978

Ro 09-1978/000

Ro-09-1978

Ro-09-1978/000

S1156_Selleck

UNII-6804DJ8Z9U

Xabine

Xeloda

Xeloda (TN)

Xeloda, Captabin, Capecitabine

ZINC03806413

Immunoglobulins

Phase 2

Antibodies

Phase 2

Immunologic Factors

Phase 2

Endothelial Growth Factors

Phase 2

Mitogens

Phase 2

Antibodies, Monoclonal

Phase 2

Anti-Infective Agents

Phase 2

Antiviral Agents

Phase 2

Angiogenesis Inhibitors

Phase 2

Immunosuppressive Agents

Phase 2

Antimetabolites

Phase 2

Antineoplastic Agents, Immunological

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase II Safety and Efficacy Study of Capecitabine, Gemcitabine, and Bevacizumab in Combination for Patients With Metastatic or Unresectable Sarcomatoid Renal Cell Carcinoma	Completed	NCT00496587	Phase 2	Capecitabine;Gemcitabine;Bevacizumab

Search NIH Clinical Center for Sarcomatoid Renal Cell Carcinoma

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Genetic Tests for Sarcomatoid Renal Cell Carcinoma

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Anatomical Context for Sarcomatoid Renal Cell Carcinoma

MalaCards organs/tissues related to Sarcomatoid Renal Cell Carcinoma:

⁴⁰

Kidney, Endothelial, Bone, Lung, Liver, Breast, Bone Marrow

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Publications for Sarcomatoid Renal Cell Carcinoma

Articles related to Sarcomatoid Renal Cell Carcinoma:

(show top 50) (show all 225)

#	Title	Authors	PMID	Year
1	An unusual case of sarcomatoid renal cell carcinoma presenting in the skin by direct extension at a laparoscopic port site. ⁶¹	Gradecki SE...Gru AA	31998984	2020
2	A Population Study to Identify Candidates for Cytoreductive Nephrectomy in Patients with Metastatic Sarcomatoid Renal Cell Carcinoma from the Surveillance, Epidemiology, and End Results (SEER) Database. ⁶¹	Ji B...Yu N	32516796	2020
3	Construction and validation of a novel prognostic nomogram for patients with sarcomatoid renal cell carcinoma: a SEER-based study. ⁶¹	Hou G...Yuan J	32361824	2020
4	MDM2-positive papillary sarcomatoid renal cell carcinoma: a potential diagnostic pitfall. ⁶¹	Jeruc J...Bostjancic E	31732813	2020
5	Propensity-score matched comparison of partial versus radical nephrectomy for T1N0M0 sarcomatoid renal cell carcinoma. ⁶¹	Ji B...Yu N	32420130	2020
6	Small Renal Mass with Sarcomatoid Features. ⁶¹	Oberle AD...Brown JA	32398998	2020
7	Outcomes Associated with First-Line anti-PD-1/ PD-L1 agents vs. Sunitinib in Patients with Sarcomatoid Renal Cell Carcinoma: A Systematic Review and Meta-Analysis. ⁶¹	Buonerba C...Di Lorenzo G	32050629	2020
8	The Role of Cytoreductive Nephrectomy for Sarcomatoid Renal Cell Carcinoma: A 29-Year Institutional Experience. ⁶¹	Silagy AW...Hakimi AA	31726184	2020
9	Salvage ipilimumab associated with a significant response in sarcomatoid renal cell carcinoma. ⁶¹	George G...Kilari D	32114501	2020
10	Pemphigus in Sarcomatoid Renal Cell Carcinoma: A Rare Paraneoplastic Manifestation. ⁶¹	Gupta A...Sideek RAT	32165843	2020
11	The predictive role of preoperative and postoperative neutrophil-lymphocyte ratio in sarcomatoid renal cell carcinoma. ⁶¹	Mano R...Hakimi AA	31590969	2019
12	A multicenter, prospective phase II trial of gemcitabine plus axitinib in patients with renal cell carcinoma with a predominant sarcomatoid component. ⁶¹	Park I...Lee JL	31231787	2019
13	Sarcomatoid Renal Cell Carcinoma With Unusual Metastasis to the Small Intestine Manifesting as Perforated Appendicitis. ⁶¹	Liao X...Zhang D	31662560	2019
14	Analysis of the factors influencing the survival time of patients with sarcomatoid renal cell carcinoma. ⁶¹	Wang YS...Yang HS	31475069	2019
15	Retrospective review of experience with sarcomatoid renal cell carcinoma: Multimodality treatment remains an unmet goal. ⁶¹	Kondisetty G...Thomas A	31649458	2019
16	Sarcomatoid Chromophobe Renal Cell Carcinoma: A Case Report and Review of the Literature. ⁶¹	Bian L...Xiao S	31423007	2019
17	Renal cell carcinomas with a mesenchymal stromal component: what do we know so far? ⁶¹	Williamson SR	31266596	2019
18	Patterns of Presentation and Treatment Outcomes of Non-clear-cell Renal Cell Carcinoma and Sarcomatoid Renal Cell Carcinoma Patients in 2 Tertiary Referral Centers in Sydney, Australia. ⁶¹	Naher S...Lim S	30935815	2019
19	Sarcomatoid Renal Cell Carcinoma: Population-Based Study of 879 Patients. ⁶¹	Alevizakos M...Appleman LJ	30799129	2019
20	Anaplastic sarcoma of the kidney: Case report and literature review. ⁶¹	Chen CC...Liao KS	31007495	2019
21	Comprehensive Genomic Profiling of Adult Renal Sarcomas Provides Insight into Disease Biology and Opportunities for Targeted Therapies. ⁶¹	Yakirevich E...Ali SM	31412008	2019
22	PAX8 Expression in Solitary Fibrous Tumor: A Potential Diagnostic Pitfall. ⁶¹	Ullman D...Stevens TM	28749793	2019
23	[CLINICAL CONSIDERATION OF PERCUTANEOUS RENAL BIOPSY FOR ADVANCED RENAL TUMOR]. ⁶¹	Ogasawara N...Igawa T	32307386	2019
24	3D reconstruction of CT scans aid in preoperative planning for sarcomatoid renal cancer: A case report and mini-review. ⁶¹	Glybochko PV...Butnaru DV	30689600	2019
25	Real-world evidence on first-line treatment for metastatic renal cell carcinoma with non-clear cell and sarcomatoid histologies: are sunitinib and pazopanib interchangeable? ⁶¹	Bonadioa RC...Dzik C	31921344	2019
26	Metastatic sarcomatoid renal cell carcinoma treated with immune checkpoint inhibitors. ⁶¹	Hanif A...George S	31413914	2019
27	A Case of Sarcomatoid Renal Cell Carcinoma With Osseous Metaplasia and Papillary Renal Cell Carcinoma Metastasis. ⁶¹	Zhang H...Guzman G	31206101	2019
28	Complete Response of a Patient With Metastatic Sarcomatoid Renal Cell Carcinoma to a Programmed Death-1 Checkpoint Inhibitor. ⁶¹	El Mouallem N...Paul AK	29920137	2018
29	Sarcomatoid renal cell carcinoma: Biology and treatment advances. ⁶¹	Mouallem NE...Paul AK	29306556	2018
30	Treatments, Outcomes, and Validity of Prognostic Scores in Patients With Sarcomatoid Renal Cell Carcinoma: A 20-Year Single-Institution Experience. ⁶¹	Korenbaum C...Barthelemy P	29395949	2018
31	Sarcomatoid renal cell carcinoma: a case report and literature review. ⁶¹	Liang X...Zhu Y	29636020	2018
32	Rapid recurrence and radiographic progression of sarcomatoid renal cell carcinoma. ⁶¹	Edelson MP...Steckel J	29034177	2018
33	Ki-67 index and percentage of sarcomatoid differentiation were two independent prognostic predictors in sarcomatoid renal cell carcinoma. ⁶¹	Wang Z...Chen Z	30464630	2018
34	Extensive Metastatic Sarcomatoid Renal Cell Carcinoma Evaluated by 18F-FDG PET/CT: a Case Report and Review of Literature. ⁶¹	Fuser D...Siegel BA	29354391	2018
35	Programmed cell death ligand 1 and tumor-infiltrating lymphocyte status in patients with renal cell carcinoma and sarcomatoid dedifferentiation. ⁶¹	Kawakami F...Karam JA	28832979	2017
36	Sarcomatoid Renal Cell Carcinoma: The Apple Doesn't Fall Far from the Tree. ⁶¹	Bergerot P...Jones J	28912138	2017
37	Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape. ⁶¹	Wang Z...Sircar K	28710314	2017
38	Immune Check Point Inhibition in Sarcomatoid Renal Cell Carcinoma: A New Treatment Paradigm. ⁶¹	Raychaudhuri R...Kilari D	28645484	2017
39	Metastatic sarcomatoid renal cell carcinoma manifesting as a subcutaneous soft tissue mass. ⁶¹	Logunova V...Iczkowski KA	28675457	2017
40	Duodenal metastases from sarcomatoid renal cell carcinoma: Case report. ⁶¹	Villela-Segura U...Nunez Becerra PJ	27506336	2017
41	Sarcomatoid Renal Cell Carcinoma and Collecting Duct Carcinoma: Discrimination From Common Renal Cell Carcinoma Subtypes and Benign RCC Mimics on Multiphasic MDCT. ⁶¹	Young JR...Raman SS	28528853	2017
42	Outcomes of Patients with Renal Cell Carcinoma and Sarcomatoid Dedifferentiation Treated with Nephrectomy and Systemic Therapies: Comparison between the Cytokine and Targeted Therapy Eras. ⁶¹	Keskin SK...Tannir NM	28411072	2017
43	Phase 2 Trial of Capecitabine, Gemcitabine, and Bevacizumab in Sarcomatoid Renal-Cell Carcinoma. ⁶¹	Maiti A...Shah AY	28870517	2017
44	Phase 2 trial of sunitinib and gemcitabine in patients with sarcomatoid and/or poor-risk metastatic renal cell carcinoma. Michaelson MD, McKay RR, Werner L, Atkins MB, Van Allen EM, Olivier KM, Song J, Signoretti S, McDermott DF, Choueiri TK.Cancer. 2015 Oct 1;121(19):3435-43. [Epub 2015 Jun 8]. doi: 10.1002/cncr.29503. ⁶¹	Jay R...Choueiri TK	28159495	2017
45	Differential expression of CD44 and CD24 markers discriminates the epitheliod from the fibroblastoid subset in a sarcomatoid renal carcinoma cell line: evidence suggesting the existence of cancer stem cells in both subsets as studied with sorted cells. ⁶¹	Hsieh CH...Liao SK	28121626	2017
46	Sarcomatoid Renal Cell Carcinoma in an Adolescent with Sickle Cell Anaemia. ⁶¹	Ahmad HR...Akuse RM	29225982	2017
47	The Pathology and Molecular Genetics of Sarcomatoid Renal Cell Carcinoma: A Mini-Review. ⁶¹	Wei S...Al-Saleem T	28725540	2017
48	Rapidly Growing Right Ventricular Outflow Tract Mass in Patient with Sarcomatoid Renal Cell Carcinoma. ⁶¹	Hwang J...Lee DS	28090262	2016
49	Comparison of oncologic outcomes between sarcomatoid and clear cell renal cell carcinoma. ⁶¹	Trudeau V...Karakiewicz PI	26902877	2016
50	Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components. ⁶¹	Manley BJ...Hsieh JJ	29167760	2016

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Genes for Sarcomatoid Renal Cell Carcinoma

Genes related to Sarcomatoid Renal Cell Carcinoma (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PAX8	Paired Box 8	Protein Coding	12.62	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	CA9	Carbonic Anhydrase 9	Protein Coding	11.9	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	11.86	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	TP53	Tumor Protein P53	Protein Coding	11.23	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	S100A1	S100 Calcium Binding Protein A1	Protein Coding	10.88	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	RELN	Reelin	Protein Coding	10.86	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	CDH1	Cadherin 1	Protein Coding	10.62	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	PTEN	Phosphatase And Tensin Homolog	Protein Coding	10.59	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	GATA3	GATA Binding Protein 3	Protein Coding	10.5	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	10.29	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	IFNA2	Interferon Alpha 2	Protein Coding	9.62	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	SSX2	SSX Family Member 2	Protein Coding	6.31	DISEASES inferred ¹⁵
13	CGB3	Chorionic Gonadotropin Subunit Beta 3	Protein Coding	6.3	GeneCards inferred via : Publications (show sections)

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Variations for Sarcomatoid Renal Cell Carcinoma

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Expression for Sarcomatoid Renal Cell Carcinoma

Search GEO for disease gene expression data for Sarcomatoid Renal Cell Carcinoma.

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Pathways for Sarcomatoid Renal Cell Carcinoma

Pathways related to Sarcomatoid Renal Cell Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	12.6	TP53 RELN PTEN KIT IFNA2
2	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.44	TP53 PTEN KIT CDH1
3	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²² Thyroid cancer ³⁶	12.1	TP53 PTEN PAX8 KIT CDH1
4	VEGF Signaling ⁶⁶ Show member pathways EGFR Signaling Pathway ⁶⁶ TGF-beta Signaling Pathway ⁶⁶ VEGF Signaling Pathway ⁶⁰	12.09	TP53 PTEN MUC1 CDH1
5	Factors involved in megakaryocyte development and platelet production ⁶⁵	11.83	TP53 IFNA2 GATA3
6	Pathways in cancer ³⁶	11.83	TP53 PTEN PAX8 KIT IFNA2 CDH1
7	Integrated Breast Cancer Pathway ¹	11.8	TP53 PTEN CDH1
8	Interleukin-4 and 13 signaling ⁶⁵	11.64	TP53 MUC1 GATA3
9	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.3	KIT IFNA2 CDH1
10	Central carbon metabolism in cancer ³⁶	11.18	TP53 PTEN KIT

Sources

GO Terms for Sarcomatoid Renal Cell Carcinoma

Cellular components related to Sarcomatoid Renal Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasmic side of plasma membrane	GO:0009898	8.8	PTEN KIT CDH1

Biological processes related to Sarcomatoid Renal Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-templated	GO:0045893	9.83	TP53 PAX8 IFNA2 GATA3 CDH1
2	positive regulation of cardiac muscle cell apoptotic process	GO:0010666	9.51	TP53 PTEN
3	embryonic hemopoiesis	GO:0035162	9.49	KIT GATA3
4	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	9.48	TP53 MUC1
5	mesonephros development	GO:0001823	9.46	PAX8 GATA3
6	central nervous system development	GO:0007417	9.46	TP53 RELN PTEN PAX8
7	otic vesicle development	GO:0071599	9.4	PAX8 GATA3
8	positive regulation of transcription from RNA polymerase II promoter in response to stress	GO:0036003	9.37	TP53 MUC1
9	response to drug	GO:0042493	9.35	TP53 PTEN GATA3 CDH1 CA9
10	positive regulation of thyroid hormone generation	GO:2000611	9.32	PAX8 GATA3
11	mast cell differentiation	GO:0060374	9.26	KIT GATA3
12	cytokine-mediated signaling pathway	GO:0019221	9.02	TP53 MUC1 KIT IFNA2 GATA3

Sources

Sources for Sarcomatoid Renal Cell Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia