MCID: SRC002
MIFTS: 38

Sarcomatoid Renal Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Sarcomatoid Renal Cell Carcinoma

MalaCards integrated aliases for Sarcomatoid Renal Cell Carcinoma:

Name: Sarcomatoid Renal Cell Carcinoma 12 15 71
Renal Cell Carcinoma, Spindle Cell 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4473
MeSH 43 D002292
NCIt 49 C27893
SNOMED-CT 67 128668003
UMLS 71 C1266043

Summaries for Sarcomatoid Renal Cell Carcinoma

MalaCards based summary : Sarcomatoid Renal Cell Carcinoma, also known as renal cell carcinoma, spindle cell, is related to malignant fibrous histiocytoma and embryonal sarcoma, and has symptoms including flank pain An important gene associated with Sarcomatoid Renal Cell Carcinoma is PAX8 (Paired Box 8), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Gastric cancer. The drugs Gemcitabine and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and bone, and related phenotypes are digestive/alimentary and muscle

Related Diseases for Sarcomatoid Renal Cell Carcinoma

Diseases related to Sarcomatoid Renal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 272)
# Related Disease Score Top Affiliating Genes
1 malignant fibrous histiocytoma 30.7 TP53 MUC1 KIT
2 embryonal sarcoma 30.4 TP53 KIT
3 chromophobe renal cell carcinoma 30.3 S100A1 MUC1 KIT
4 leiomyosarcoma 30.2 TP53 S100A1 MUC1 KIT
5 cystitis 30.1 TP53 KIT CDH1
6 rhabdoid tumor predisposition syndrome 1 30.1 TP53 MUC1
7 papillary carcinoma 30.0 S100A1 PAX8 MUC1 CDH1
8 kidney cancer 29.9 TP53 PTEN IFNA2 CA9
9 fibrosarcoma 29.9 TP53 SSX2 KIT CA9
10 sarcoma, synovial 29.6 SSX2 MUC1 KIT CDH1
11 rhabdomyosarcoma 29.6 TP53 SSX2 PTEN KIT
12 clear cell renal cell carcinoma 29.6 TP53 PTEN PAX8 MUC1 CDH1 CA9
13 adenocarcinoma 29.3 TP53 PTEN MUC1 KIT CDH1
14 renal cell carcinoma, nonpapillary 29.3 TP53 S100A1 PTEN PAX8 MUC1 KIT
15 gastrointestinal stromal tumor 29.3 TP53 S100A1 PTEN KIT CDH1
16 sarcoma 29.0 TP53 SSX2 S100A1 MUC1 KIT IFNA2
17 dedifferentiated liposarcoma 28.9 TP53 SSX2 S100A1 PTEN MUC1 KIT
18 carcinosarcoma 28.7 TP53 S100A1 PTEN PAX8 MUC1 KIT
19 renal cell carcinoma, papillary, 1 28.7 TP53 S100A1 PTEN PAX8 KIT CDH1
20 bladder cancer 27.7 TP53 PTEN MUC1 IFNA2 CGB3 CDH1
21 ischemic fasciitis 10.5 S100A1 MUC1
22 papillary tumor of the pineal region 10.5 S100A1 MUC1
23 clear cell adenoma 10.5 S100A1 PAX8
24 reticular perineurioma 10.4 MUC1 KIT
25 intraneural perineurioma 10.4 S100A1 MUC1
26 axillary lipoma 10.4 MUC1 KIT
27 chondroid chordoma 10.4 S100A1 MUC1
28 krukenberg carcinoma 10.4 PAX8 MUC1
29 parachordoma 10.4 S100A1 MUC1
30 reticulum cell sarcoma 10.4 S100A1 MUC1
31 pericardial mesothelioma 10.4 S100A1 MUC1
32 pancreatic foamy gland adenocarcinoma 10.4 TP53 MUC1
33 cystadenofibroma 10.4 PAX8 MUC1
34 bile duct mucinous adenocarcinoma 10.4 TP53 MUC1
35 chordoid meningioma 10.4 S100A1 MUC1
36 colon leiomyosarcoma 10.4 PAX8 KIT
37 ossifying fibromyxoid tumor 10.4 S100A1 MUC1
38 ovarian seromucinous carcinoma 10.4 TP53 PAX8
39 ovarian mixed germ cell neoplasm 10.4 PAX8 KIT
40 glandular cystitis 10.4 TP53 MUC1
41 gallbladder signet ring cell adenocarcinoma 10.4 MUC1 CDH1
42 biliary tract benign neoplasm 10.4 TP53 MUC1
43 tumor of exocrine pancreas 10.4 TP53 MUC1
44 intratubular embryonal carcinoma 10.3 TP53 KIT
45 suppressor of tumorigenicity 3 10.3 TP53 CA9
46 renal pelvis adenocarcinoma 10.3 PAX8 CDH1
47 spindle cell carcinoma 10.3
48 ovarian serous cystadenofibroma 10.3 TP53 MUC1
49 breast malignant phyllodes tumor 10.3 TP53 KIT
50 linitis plastica 10.3 MUC1 CDH1

Graphical network of the top 20 diseases related to Sarcomatoid Renal Cell Carcinoma:



Diseases related to Sarcomatoid Renal Cell Carcinoma

Symptoms & Phenotypes for Sarcomatoid Renal Cell Carcinoma

UMLS symptoms related to Sarcomatoid Renal Cell Carcinoma:


flank pain

MGI Mouse Phenotypes related to Sarcomatoid Renal Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 CA9 CDH1 GATA3 KIT PTEN RELN
2 muscle MP:0005369 9.43 GATA3 KIT PTEN RELN S100A1 TP53
3 normal MP:0002873 9.17 CDH1 GATA3 KIT PAX8 PTEN S100A1

Drugs & Therapeutics for Sarcomatoid Renal Cell Carcinoma

Drugs for Sarcomatoid Renal Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 2 95058-81-4 60750
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
4 Immunoglobulins Phase 2
5 Antibodies Phase 2
6 Immunologic Factors Phase 2
7 Endothelial Growth Factors Phase 2
8 Mitogens Phase 2
9 Antibodies, Monoclonal Phase 2
10 Anti-Infective Agents Phase 2
11 Antiviral Agents Phase 2
12 Angiogenesis Inhibitors Phase 2
13 Immunosuppressive Agents Phase 2
14 Antimetabolites Phase 2
15 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Safety and Efficacy Study of Capecitabine, Gemcitabine, and Bevacizumab in Combination for Patients With Metastatic or Unresectable Sarcomatoid Renal Cell Carcinoma Completed NCT00496587 Phase 2 Capecitabine;Gemcitabine;Bevacizumab

Search NIH Clinical Center for Sarcomatoid Renal Cell Carcinoma

Genetic Tests for Sarcomatoid Renal Cell Carcinoma

Anatomical Context for Sarcomatoid Renal Cell Carcinoma

MalaCards organs/tissues related to Sarcomatoid Renal Cell Carcinoma:

40
Kidney, Endothelial, Bone, Lung, Liver, Breast, Bone Marrow

Publications for Sarcomatoid Renal Cell Carcinoma

Articles related to Sarcomatoid Renal Cell Carcinoma:

(show top 50) (show all 225)
# Title Authors PMID Year
1
An unusual case of sarcomatoid renal cell carcinoma presenting in the skin by direct extension at a laparoscopic port site. 61
31998984 2020
2
A Population Study to Identify Candidates for Cytoreductive Nephrectomy in Patients with Metastatic Sarcomatoid Renal Cell Carcinoma from the Surveillance, Epidemiology, and End Results (SEER) Database. 61
32516796 2020
3
Construction and validation of a novel prognostic nomogram for patients with sarcomatoid renal cell carcinoma: a SEER-based study. 61
32361824 2020
4
MDM2-positive papillary sarcomatoid renal cell carcinoma: a potential diagnostic pitfall. 61
31732813 2020
5
Propensity-score matched comparison of partial versus radical nephrectomy for T1N0M0 sarcomatoid renal cell carcinoma. 61
32420130 2020
6
Small Renal Mass with Sarcomatoid Features. 61
32398998 2020
7
Outcomes Associated with First-Line anti-PD-1/ PD-L1 agents vs. Sunitinib in Patients with Sarcomatoid Renal Cell Carcinoma: A Systematic Review and Meta-Analysis. 61
32050629 2020
8
The Role of Cytoreductive Nephrectomy for Sarcomatoid Renal Cell Carcinoma: A 29-Year Institutional Experience. 61
31726184 2020
9
Salvage ipilimumab associated with a significant response in sarcomatoid renal cell carcinoma. 61
32114501 2020
10
Pemphigus in Sarcomatoid Renal Cell Carcinoma: A Rare Paraneoplastic Manifestation. 61
32165843 2020
11
The predictive role of preoperative and postoperative neutrophil-lymphocyte ratio in sarcomatoid renal cell carcinoma. 61
31590969 2019
12
A multicenter, prospective phase II trial of gemcitabine plus axitinib in patients with renal cell carcinoma with a predominant sarcomatoid component. 61
31231787 2019
13
Sarcomatoid Renal Cell Carcinoma With Unusual Metastasis to the Small Intestine Manifesting as Perforated Appendicitis. 61
31662560 2019
14
Analysis of the factors influencing the survival time of patients with sarcomatoid renal cell carcinoma. 61
31475069 2019
15
Retrospective review of experience with sarcomatoid renal cell carcinoma: Multimodality treatment remains an unmet goal. 61
31649458 2019
16
Sarcomatoid Chromophobe Renal Cell Carcinoma: A Case Report and Review of the Literature. 61
31423007 2019
17
Renal cell carcinomas with a mesenchymal stromal component: what do we know so far? 61
31266596 2019
18
Patterns of Presentation and Treatment Outcomes of Non-clear-cell Renal Cell Carcinoma and Sarcomatoid Renal Cell Carcinoma Patients in 2 Tertiary Referral Centers in Sydney, Australia. 61
30935815 2019
19
Sarcomatoid Renal Cell Carcinoma: Population-Based Study of 879 Patients. 61
30799129 2019
20
Anaplastic sarcoma of the kidney: Case report and literature review. 61
31007495 2019
21
Comprehensive Genomic Profiling of Adult Renal Sarcomas Provides Insight into Disease Biology and Opportunities for Targeted Therapies. 61
31412008 2019
22
PAX8 Expression in Solitary Fibrous Tumor: A Potential Diagnostic Pitfall. 61
28749793 2019
23
[CLINICAL CONSIDERATION OF PERCUTANEOUS RENAL BIOPSY FOR ADVANCED RENAL TUMOR]. 61
32307386 2019
24
3D reconstruction of CT scans aid in preoperative planning for sarcomatoid renal cancer: A case report and mini-review. 61
30689600 2019
25
Real-world evidence on first-line treatment for metastatic renal cell carcinoma with non-clear cell and sarcomatoid histologies: are sunitinib and pazopanib interchangeable? 61
31921344 2019
26
Metastatic sarcomatoid renal cell carcinoma treated with immune checkpoint inhibitors. 61
31413914 2019
27
A Case of Sarcomatoid Renal Cell Carcinoma With Osseous Metaplasia and Papillary Renal Cell Carcinoma Metastasis. 61
31206101 2019
28
Complete Response of a Patient With Metastatic Sarcomatoid Renal Cell Carcinoma to a Programmed Death-1 Checkpoint Inhibitor. 61
29920137 2018
29
Sarcomatoid renal cell carcinoma: Biology and treatment advances. 61
29306556 2018
30
Treatments, Outcomes, and Validity of Prognostic Scores in Patients With Sarcomatoid Renal Cell Carcinoma: A 20-Year Single-Institution Experience. 61
29395949 2018
31
Sarcomatoid renal cell carcinoma: a case report and literature review. 61
29636020 2018
32
Rapid recurrence and radiographic progression of sarcomatoid renal cell carcinoma. 61
29034177 2018
33
Ki-67 index and percentage of sarcomatoid differentiation were two independent prognostic predictors in sarcomatoid renal cell carcinoma. 61
30464630 2018
34
Extensive Metastatic Sarcomatoid Renal Cell Carcinoma Evaluated by 18F-FDG PET/CT: a Case Report and Review of Literature. 61
29354391 2018
35
Programmed cell death ligand 1 and tumor-infiltrating lymphocyte status in patients with renal cell carcinoma and sarcomatoid dedifferentiation. 61
28832979 2017
36
Sarcomatoid Renal Cell Carcinoma: The Apple Doesn't Fall Far from the Tree. 61
28912138 2017
37
Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape. 61
28710314 2017
38
Immune Check Point Inhibition in Sarcomatoid Renal Cell Carcinoma: A New Treatment Paradigm. 61
28645484 2017
39
Metastatic sarcomatoid renal cell carcinoma manifesting as a subcutaneous soft tissue mass. 61
28675457 2017
40
Duodenal metastases from sarcomatoid renal cell carcinoma: Case report. 61
27506336 2017
41
Sarcomatoid Renal Cell Carcinoma and Collecting Duct Carcinoma: Discrimination From Common Renal Cell Carcinoma Subtypes and Benign RCC Mimics on Multiphasic MDCT. 61
28528853 2017
42
Outcomes of Patients with Renal Cell Carcinoma and Sarcomatoid Dedifferentiation Treated with Nephrectomy and Systemic Therapies: Comparison between the Cytokine and Targeted Therapy Eras. 61
28411072 2017
43
Phase 2 Trial of Capecitabine, Gemcitabine, and Bevacizumab in Sarcomatoid Renal-Cell Carcinoma. 61
28870517 2017
44
Phase 2 trial of sunitinib and gemcitabine in patients with sarcomatoid and/or poor-risk metastatic renal cell carcinoma. Michaelson MD, McKay RR, Werner L, Atkins MB, Van Allen EM, Olivier KM, Song J, Signoretti S, McDermott DF, Choueiri TK.Cancer. 2015 Oct 1;121(19):3435-43. [Epub 2015 Jun 8]. doi: 10.1002/cncr.29503. 61
28159495 2017
45
Differential expression of CD44 and CD24 markers discriminates the epitheliod from the fibroblastoid subset in a sarcomatoid renal carcinoma cell line: evidence suggesting the existence of cancer stem cells in both subsets as studied with sorted cells. 61
28121626 2017
46
Sarcomatoid Renal Cell Carcinoma in an Adolescent with Sickle Cell Anaemia. 61
29225982 2017
47
The Pathology and Molecular Genetics of Sarcomatoid Renal Cell Carcinoma: A Mini-Review. 61
28725540 2017
48
Rapidly Growing Right Ventricular Outflow Tract Mass in Patient with Sarcomatoid Renal Cell Carcinoma. 61
28090262 2016
49
Comparison of oncologic outcomes between sarcomatoid and clear cell renal cell carcinoma. 61
26902877 2016
50
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components. 61
29167760 2016

Variations for Sarcomatoid Renal Cell Carcinoma

Expression for Sarcomatoid Renal Cell Carcinoma

Search GEO for disease gene expression data for Sarcomatoid Renal Cell Carcinoma.

Pathways for Sarcomatoid Renal Cell Carcinoma

GO Terms for Sarcomatoid Renal Cell Carcinoma

Cellular components related to Sarcomatoid Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic side of plasma membrane GO:0009898 8.8 PTEN KIT CDH1

Biological processes related to Sarcomatoid Renal Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.83 TP53 PAX8 IFNA2 GATA3 CDH1
2 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.51 TP53 PTEN
3 embryonic hemopoiesis GO:0035162 9.49 KIT GATA3
4 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.48 TP53 MUC1
5 mesonephros development GO:0001823 9.46 PAX8 GATA3
6 central nervous system development GO:0007417 9.46 TP53 RELN PTEN PAX8
7 otic vesicle development GO:0071599 9.4 PAX8 GATA3
8 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.37 TP53 MUC1
9 response to drug GO:0042493 9.35 TP53 PTEN GATA3 CDH1 CA9
10 positive regulation of thyroid hormone generation GO:2000611 9.32 PAX8 GATA3
11 mast cell differentiation GO:0060374 9.26 KIT GATA3
12 cytokine-mediated signaling pathway GO:0019221 9.02 TP53 MUC1 KIT IFNA2 GATA3

Sources for Sarcomatoid Renal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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