MCID: SRC002
MIFTS: 40

Sarcomatoid Renal Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Sarcomatoid Renal Cell Carcinoma

MalaCards integrated aliases for Sarcomatoid Renal Cell Carcinoma:

Name: Sarcomatoid Renal Cell Carcinoma 12 15 73
Renal Cell Carcinoma, Spindle Cell 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4473
MeSH 44 D002292
NCIt 50 C27893
UMLS 73 C1266043

Summaries for Sarcomatoid Renal Cell Carcinoma

MalaCards based summary : Sarcomatoid Renal Cell Carcinoma, also known as renal cell carcinoma, spindle cell, is related to renal cell carcinoma, nonpapillary and sarcoma, synovial, and has symptoms including flank pain An important gene associated with Sarcomatoid Renal Cell Carcinoma is PAX8 (Paired Box 8), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Nivolumab and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include endothelial, kidney and skin, and related phenotypes are embryo and normal

Related Diseases for Sarcomatoid Renal Cell Carcinoma

Diseases related to Sarcomatoid Renal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 renal cell carcinoma, nonpapillary 30.8 CDH1 IFNA2 KIT MUC1 PAX8
2 sarcoma, synovial 29.8 CDH1 KIT MUC1
3 endosalpingiosis 10.2 MUC1 PAX8
4 reticular perineurioma 10.2 KIT MUC1
5 perineurioma 10.2 KIT MUC1
6 aggressive digital papillary adenocarcinoma 10.2 KIT MUC1
7 perivascular epithelioid cell tumor 10.2 KIT MUC1
8 dermoid cyst 10.2 KIT MUC1
9 water-clear cell adenoma 10.2 GATA3 PAX8
10 polymorphous low-grade adenocarcinoma 10.2 KIT MUC1
11 rete testis neoplasm 10.2 KIT PAX8
12 prostatic acinar adenocarcinoma 10.1 KIT PAX8
13 cribriform carcinoma 10.1 GATA3 KIT
14 embryoma 10.1 GATA3 KIT
15 chronic orbital inflammation 10.1 IFNA2 MUC1
16 mixed germ cell tumor 10.1 CGB3 KIT
17 dysgerminoma 10.1 KIT MUC1
18 neurofibroma 10.1 KIT MUC1
19 aggressive systemic mastocytosis 10.1 IFNA2 KIT
20 sarcoma 10.1
21 viral infectious disease 10.1
22 systemic mastocytosis 10.1 IFNA2 KIT
23 cavernous hemangioma 10.1 KIT MUC1
24 mixed ductal-endocrine carcinoma 10.1 CGB3 MUC1
25 adenosquamous carcinoma 10.1 KIT MUC1
26 malignant skin fibrous histiocytoma 10.1 IFNA2 KIT
27 angiosarcoma 10.1 KIT MUC1
28 anaplastic ependymoma 10.1 MUC1 PTEN
29 malignant dermis tumor 10.1 IFNA2 KIT
30 ovarian melanoma 10.1 KIT PTEN
31 acral lentiginous melanoma 10.1 KIT PTEN
32 oncocytoma 10.1 KIT MUC1
33 prostate small cell carcinoma 10.1 KIT PTEN
34 small cell carcinoma 10.1 KIT PTEN
35 thymus cancer 10.1 KIT MUC1 PAX8
36 thrombocytopenic purpura, autoimmune 10.0 GATA3 IFNA2
37 biphasic synovial sarcoma 10.0 CDH1 MUC1
38 papillary adenocarcinoma 10.0 CDH1 MUC1
39 serotonin syndrome 10.0 CGB3 IFNA2
40 renal pelvis adenocarcinoma 10.0 CDH1 PAX8
41 signet ring cell adenocarcinoma 10.0 CDH1 MUC1
42 ovarian brenner tumor 10.0 GATA3 KIT PAX8
43 merkel cell carcinoma 10.0 KIT MUC1
44 lobular neoplasia 10.0 CDH1 MUC1
45 lymphoepithelioma-like carcinoma 10.0 CDH1 MUC1
46 chondroid chordoma 10.0 CDH1 MUC1
47 tubular adenocarcinoma 10.0 CDH1 MUC1
48 bile duct adenocarcinoma 10.0 CDH1 MUC1
49 follicular adenoma 10.0 PAX8 PTEN
50 gastric signet ring cell adenocarcinoma 10.0 CDH1 GATA3

Graphical network of the top 20 diseases related to Sarcomatoid Renal Cell Carcinoma:



Diseases related to Sarcomatoid Renal Cell Carcinoma

Symptoms & Phenotypes for Sarcomatoid Renal Cell Carcinoma

UMLS symptoms related to Sarcomatoid Renal Cell Carcinoma:


flank pain

MGI Mouse Phenotypes related to Sarcomatoid Renal Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.35 CDH1 GATA3 KIT PAX8 PTEN
2 normal MP:0002873 9.02 CDH1 GATA3 KIT PAX8 PTEN

Drugs & Therapeutics for Sarcomatoid Renal Cell Carcinoma

Drugs for Sarcomatoid Renal Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nivolumab Approved Phase 3,Phase 2,Phase 1 946414-94-4
2 Immunologic Factors Phase 3,Phase 2,Phase 1
3 Antibodies Phase 3,Phase 2,Phase 1
4 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
5 Immunoglobulins Phase 3,Phase 2,Phase 1
6
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
7
Gemcitabine Approved Phase 2 95058-81-4 60750
8
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
9
Lenograstim Approved, Investigational Phase 2 135968-09-1
10
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
11
Nicotinamide Approved, Investigational Phase 1, Phase 2,Phase 2 98-92-0 936
12
Sorafenib Approved, Investigational Phase 1, Phase 2 284461-73-0 216239 406563
13
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
14
Niacin Approved, Investigational, Nutraceutical Phase 1, Phase 2,Phase 2 59-67-6 938
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
16
Doxil Approved June 1999 Phase 2 31703
17 Antiviral Agents Phase 2
18 Angiogenesis Inhibitors Phase 2,Phase 1
19 Antimetabolites Phase 2
20 Antimetabolites, Antineoplastic Phase 2
21 Anti-Infective Agents Phase 2
22 Angiogenesis Modulating Agents Phase 2,Phase 1
23 Endothelial Growth Factors Phase 2
24 Immunosuppressive Agents Phase 2
25 Mitogens Phase 2
26 Adjuvants, Immunologic Phase 2
27 Anti-Bacterial Agents Phase 2
28 Antibiotics, Antitubercular Phase 2
29 Topoisomerase Inhibitors Phase 2
30 Vitamin B Complex Phase 1, Phase 2
31 Protein Kinase Inhibitors Phase 1, Phase 2
32 Nicotinic Acids Phase 1, Phase 2
33 Vitamin B9 Phase 1, Phase 2
34 Vitamins Phase 1, Phase 2
35 Trace Elements Phase 1, Phase 2
36 Vitamin B3 Phase 1, Phase 2
37 Folate Phase 1, Phase 2
38 Micronutrients Phase 1, Phase 2
39 Pharmaceutical Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab in Treating Patients With Localized Kidney Cancer Undergoing Nephrectomy Recruiting NCT03055013 Phase 3
2 Nivolumab and Ipilimumab Followed by Nivolumab Versus Cabozantinib and Nivolumab in Treating Patients With Metastatic Untreated Renal Cell Cancer Not yet recruiting NCT03793166 Phase 3 Cabozantinib
3 Capecitabine, Gemcitabine, and Bevacizumab in Combination for Patients With Sarcomatoid Renal Cell Carcinoma Completed NCT00496587 Phase 2 Capecitabine;Gemcitabine;Bevacizumab
4 Doxorubicin and Gemcitabine in Treating Patients With Locally Recurrent or Metastatic Unresectable Renal Cell Carcinoma Completed NCT00068393 Phase 2 Doxorubicin;Gemcitabine;G-CSF (granulocyte-colony stimulating factor);Neulasta
5 Sorafenib Tosylate and Bevacizumab in Treating Patients With Advanced Kidney Cancer Completed NCT00126503 Phase 1, Phase 2 Sorafenib Tosylate
6 Phase II Sequential Treatment Trial of Single Agent Nivolumab, Then Combination Ipilimumab + Nivolumab in Metastatic or Unresectable Non-Clear Cell Renal Cell Carcinoma (ANZUP1602) Recruiting NCT03177239 Phase 2 Nivolumab;Ipilimumab
7 Sunitinib Malate With or Without Gemcitabine Hydrochloride in Treating Patients With Advanced Kidney Cancer That Cannot Be Removed By Surgery Active, not recruiting NCT01164228 Phase 2 gemcitabine hydrochloride;sunitinib malate
8 Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer Active, not recruiting NCT01767636 Phase 2 Pazopanib Hydrochloride
9 ANZUP - Non-clear Cell Post Immunotherapy CABozantinib (UNICAB) Not yet recruiting NCT03685448 Phase 2 Cabozantinib
10 Cabozantinib-s-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors Recruiting NCT02496208 Phase 1 Cabozantinib S-malate

Search NIH Clinical Center for Sarcomatoid Renal Cell Carcinoma

Genetic Tests for Sarcomatoid Renal Cell Carcinoma

Anatomical Context for Sarcomatoid Renal Cell Carcinoma

MalaCards organs/tissues related to Sarcomatoid Renal Cell Carcinoma:

41
Endothelial, Kidney, Skin, Ovary, Prostate, Thyroid, Thymus

Publications for Sarcomatoid Renal Cell Carcinoma

Articles related to Sarcomatoid Renal Cell Carcinoma:

(show top 50) (show all 124)
# Title Authors Year
1
Extensive Metastatic Sarcomatoid Renal Cell Carcinoma Evaluated by<sup>18</sup>F-FDG PET/CT: a Case Report and Review of Literature. ( 29354391 )
2018
2
Complete Response of a Patient With Metastatic Sarcomatoid Renal Cell Carcinoma to a Programmed Death-1 Checkpoint Inhibitor. ( 29920137 )
2018
3
Sarcomatoid renal cell carcinoma: Biology and treatment advances. ( 29306556 )
2018
4
Sarcomatoid renal cell carcinoma: a case report and literature review. ( 29636020 )
2018
5
Rapid recurrence and radiographic progression of sarcomatoid renal cell carcinoma. ( 29034177 )
2018
6
Treatments, Outcomes, and Validity of Prognostic Scores in Patients With Sarcomatoid Renal Cell Carcinoma: A 20-Year Single-Institution Experience. ( 29395949 )
2018
7
Ki-67 index and percentage of sarcomatoid differentiation were two independent prognostic predictors in sarcomatoid renal cell carcinoma. ( 30464630 )
2018
8
Duodenal metastases from sarcomatoid renal cell carcinoma: Case report. ( 27506336 )
2017
9
Sarcomatoid Renal Cell Carcinoma and Collecting Duct Carcinoma: Discrimination From Common Renal Cell Carcinoma Subtypes and Benign RCC Mimics on Multiphasic MDCT. ( 28528853 )
2017
10
Sarcomatoid Renal Cell Carcinoma: The Apple Doesn't Fall Far From the Tree. ( 28912138 )
2017
11
Phase 2 Trial of Capecitabine, Gemcitabine, and Bevacizumab in Sarcomatoid Renal-Cell Carcinoma. ( 28870517 )
2017
12
The Pathology and Molecular Genetics of Sarcomatoid Renal Cell Carcinoma: A Mini-Review. ( 28725540 )
2017
13
Metastatic sarcomatoid renal cell carcinoma manifesting as a subcutaneous soft tissue mass. ( 28675457 )
2017
14
Sarcomatoid renal cell carcinoma has a distinct molecular pathogenesis, driver mutation profile and transcriptional landscape. ( 28710314 )
2017
15
Immune Check Point Inhibition in Sarcomatoid Renal Cell Carcinoma: A New Treatment Paradigm. ( 28645484 )
2017
16
Sarcomatoid Renal Cell Carcinoma in an Adolescent with Sickle Cell Anaemia. ( 29225982 )
2017
17
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components. ( 29167760 )
2016
18
Prognostic value of preoperative inflammatory response biomarkers in patients with sarcomatoid renal cell carcinoma and the establishment of a nomogram. ( 27035802 )
2016
19
Radiographic Kinetics of Sarcomatoid Renal Cell Carcinoma. ( 27041470 )
2016
20
Rapidly Growing Right Ventricular Outflow Tract Mass in Patient with Sarcomatoid Renal Cell Carcinoma. ( 28090262 )
2016
21
Outcome of patients with metastatic sarcomatoid renal cell carcinoma: results from the international metastatic renal cell carcinoma database consortium. ( 25450036 )
2015
22
Sarcomatoid Renal Cell Carcinoma Metastasis to the Penis. ( 26257975 )
2015
23
Long-term survival following multidisciplinary treatment of metastatic sarcomatoid renal cell carcinoma: a case report. ( 26582158 )
2015
24
Does postoperative radiation therapy impact survival in non-metastatic sarcomatoid renal cell carcinoma? A SEER-based study. ( 26329746 )
2015
25
Diagnosis of Sarcomatoid Renal Cell Carcinoma With CT: Evaluation by Qualitative Imaging Features and Texture Analysis. ( 25905936 )
2015
26
Clinicopathologic characteristics and prognostic factors of sarcomatoid renal cell carcinoma. ( 25178995 )
2014
27
Leukemoid reaction in sarcomatoid renal cell carcinoma: a two-case report. ( 24745762 )
2014
28
A novel prognostic model for patients with sarcomatoid renal cell carcinoma. ( 24730416 )
2014
29
Sarcomatoid renal cell carcinoma: case report and review of literature. ( 25177568 )
2014
30
Successful mammalian target of rapamycin inhibitor maintenance therapy following induction chemotherapy with gemcitabine and doxorubicin for metastatic sarcomatoid renal cell carcinoma. ( 24959297 )
2014
31
Sarcomatoid renal cell carcinoma: clinical outcome and survival after treatment with sunitinib. ( 24560086 )
2014
32
A 78-year-old man with rapidly-progressing sarcomatoid renal cell carcinoma. ( 23923252 )
2013
33
Use of PAX8 and GATA3 in diagnosing sarcomatoid renal cell carcinoma and sarcomatoid urothelial carcinoma. ( 23453625 )
2013
34
Curability of poor-risk metastatic sarcomatoid renal cell carcinoma with the combination of gemcitabine, 5-fluorouracil, and interferon-alfa: a case report of a 55-year-old man with a 10-year complete remission. ( 23665133 )
2013
35
Sarcomatoid renal cell carcinoma with rhabdoid features. ( 24188946 )
2013
36
Characteristic MRI findings of sarcomatoid renal cell carcinoma dedifferentiated from clear cell renal carcinoma: radiological-pathological correlation. ( 23834905 )
2013
37
Sarcomatoid renal cell carcinoma with scant epithelial components in an Angora cat. ( 23600482 )
2013
38
Clinical outcome in patients receiving systemic therapy for metastatic sarcomatoid renal cell carcinoma: a retrospective analysis. ( 22608544 )
2013
39
Sarcomatoid renal cell carcinoma. ( 22704447 )
2012
40
Sarcomatoid renal cell carcinoma: a case report and literature review. ( 22690291 )
2012
41
Sarcomatoid renal cell carcinoma: a comprehensive review of the biology and current treatment strategies. ( 22234634 )
2012
42
Impact of pathological tumour characteristics in patients with sarcomatoid renal cell carcinoma. ( 22221668 )
2012
43
Combination of gemcitabine and doxorubicin in rapidly progressive metastatic renal cell carcinoma and/or sarcomatoid renal cell carcinoma. ( 21720184 )
2011
44
Systemic therapy for sarcomatoid renal cell carcinoma. ( 21707288 )
2011
45
Sarcomatoid renal cell carcinoma. ( 21196626 )
2011
46
A 51-year-old man with rapidly progressive metastatic sarcomatoid renal cell carcinoma: an apparent complete clinical response to second-line therapy with sunitinib and low-dose interferon-alpha. ( 21326149 )
2011
47
Sarcomatoid renal cell carcinoma is an example of epithelial--mesenchymal transition. ( 22003062 )
2011
48
Hydrocele: an atypical presentation of metastatic sarcomatoid renal cell carcinoma. ( 21703053 )
2011
49
Pathologic significance and prognostic value of phosphorylated cortactin expression in patients with sarcomatoid renal cell carcinoma. ( 21696810 )
2011
50
A progesterone-receptor-positive huge retroperitoneal tumour mimics metastasis in a breast cancer patient: sarcomatoid renal cell carcinoma. ( 21618856 )
2011

Variations for Sarcomatoid Renal Cell Carcinoma

Expression for Sarcomatoid Renal Cell Carcinoma

Search GEO for disease gene expression data for Sarcomatoid Renal Cell Carcinoma.

Pathways for Sarcomatoid Renal Cell Carcinoma

Pathways related to Sarcomatoid Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.2 CDH1 KIT PAX8 PTEN
2 11.74 CDH1 IFNA2 KIT PAX8 PTEN
3 11.03 CDH1 GATA3
4 11 CDH1 IFNA2 KIT

GO Terms for Sarcomatoid Renal Cell Carcinoma

Cellular components related to Sarcomatoid Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic side of plasma membrane GO:0009898 8.8 CDH1 KIT PTEN

Biological processes related to Sarcomatoid Renal Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.71 CDH1 GATA3 IFNA2 PAX8
2 response to drug GO:0042493 9.69 CDH1 GATA3 PTEN
3 inner ear morphogenesis GO:0042472 9.55 GATA3 PAX8
4 synapse assembly GO:0007416 9.54 CDH1 PTEN
5 humoral immune response GO:0006959 9.52 GATA3 IFNA2
6 erythrocyte differentiation GO:0030218 9.49 GATA3 KIT
7 T cell differentiation GO:0030217 9.48 GATA3 KIT
8 regulation of neuron projection development GO:0010975 9.46 GATA3 PTEN
9 cytokine-mediated signaling pathway GO:0019221 9.46 GATA3 IFNA2 KIT MUC1
10 ventricular septum development GO:0003281 9.43 GATA3 PAX8
11 embryonic hemopoiesis GO:0035162 9.37 GATA3 KIT
12 mesonephros development GO:0001823 9.32 GATA3 PAX8
13 otic vesicle development GO:0071599 9.26 GATA3 PAX8
14 mast cell differentiation GO:0060374 8.96 GATA3 KIT
15 positive regulation of thyroid hormone generation GO:2000611 8.62 GATA3 PAX8

Sources for Sarcomatoid Renal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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