MCID: SRC008
MIFTS: 27

Sarcomatoid Squamous Cell Skin Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Sarcomatoid Squamous Cell Skin Carcinoma

MalaCards integrated aliases for Sarcomatoid Squamous Cell Skin Carcinoma:

Name: Sarcomatoid Squamous Cell Skin Carcinoma 12 15
Spindle Cell Squamous Cell Carcinoma 12 70
Spindle Cell Squamous Cell Skin Carcinoma 12
Spindle Cell Squamous Carcinoma of Skin 12
Spindle Cell Squamous Cell Carcinoma 12
Squamous Cell Carcinoma, Sarcomatoid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5536
NCIt 50 C27084
SNOMED-CT 67 10288008
UMLS 70 C0349656

Summaries for Sarcomatoid Squamous Cell Skin Carcinoma

MalaCards based summary : Sarcomatoid Squamous Cell Skin Carcinoma, also known as spindle cell squamous cell carcinoma, is related to leiomyosarcoma and keratosis, seborrheic. An important gene associated with Sarcomatoid Squamous Cell Skin Carcinoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include skin, breast and bone.

Related Diseases for Sarcomatoid Squamous Cell Skin Carcinoma

Diseases related to Sarcomatoid Squamous Cell Skin Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 297)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 30.7 SERPINA3 PECAM1 MLANA
2 keratosis, seborrheic 30.2 MLANA KRT5
3 cutaneous leiomyosarcoma 30.0 CD68 CD34 CALD1
4 malignant spindle cell melanoma 29.9 SERPINA3 MLANA CD68 CD34
5 basal cell carcinoma 29.2 MME KRT8 KRT5 CD68 CD34
6 cutaneous fibrous histiocytoma 29.2 SERPINA3 MME MLANA CD68 CD34
7 skin carcinoma 28.7 PECAM1 MME MLANA KRT8 KRT5 CD68
8 squamous cell carcinoma 10.7
9 keratosis 10.3
10 acanthoma 10.3 MLANA KRT5
11 gastric squamous cell carcinoma 10.3 SERPINA3 KRT5
12 breast secretory carcinoma 10.3 SERPINA3 KRT5
13 penis sarcoma 10.3 MLANA CD34
14 sensory organ benign neoplasm 10.3 MLANA KRT5
15 large cell acanthoma 10.3 MLANA KRT5
16 epidural spinal canal neoplasm 10.3 MLANA CD34
17 spermatic cord cancer 10.3 KRT5 CD34
18 lung sarcoma 10.3 SERPINA3 CD34
19 liver fibroma 10.3 KRT5 CD34
20 hepatic angiomyolipoma 10.3 MLANA CD34
21 mucinous stomach adenocarcinoma 10.3 MLANA KRT5
22 thymus clear cell carcinoma 10.3 MLANA KRT5
23 apocrine adenocarcinoma 10.3 SERPINA3 KRT5
24 melanoma 10.2
25 gallbladder melanoma 10.2 PECAM1 MLANA
26 epithelioid malignant peripheral nerve sheath tumor 10.2 MLANA CD34
27 juvenile xanthogranuloma 10.2 SERPINA3 MLANA
28 skin epithelioid hemangioma 10.2 PECAM1 CD34
29 bartholin's gland adenocarcinoma 10.2 MLANA KRT5
30 aortic malignant tumor 10.2 PECAM1 CD34
31 prostate angiosarcoma 10.2 PECAM1 CD34
32 central nervous system angiosarcoma 10.2 PECAM1 CD34
33 central nervous system hemangioma 10.2 PECAM1 CD34
34 heart fibrosarcoma 10.2 PECAM1 CD34
35 ovarian angiosarcoma 10.2 PECAM1 CD34
36 conventional angiosarcoma 10.2 PECAM1 CD34
37 nasal cavity cancer 10.2 MLANA KRT5
38 pediatric fibrosarcoma 10.2 SERPINA3 CD34
39 borst-jadassohn intraepidermal carcinoma 10.2 MLANA KRT5
40 thyroid sarcoma 10.2 PECAM1 CD34
41 pediatric angiosarcoma 10.2 PECAM1 CD34
42 breast hemangioma 10.2 PECAM1 CD34
43 hemangioma of spleen 10.2 PECAM1 CD34
44 malignant fibrous histiocytoma of bone 10.2 SERPINA3 CALD1
45 ovarian melanoma 10.2 MLANA CALD1
46 skin tag 10.2 SERPINA3 CD34
47 paget disease, extramammary 10.2 MLANA KRT5
48 intramuscular hemangioma 10.2 PECAM1 CD34
49 liposarcoma of bone 10.2 PECAM1 CD34
50 colonic lymphangioma 10.2 PECAM1 CD34

Graphical network of the top 20 diseases related to Sarcomatoid Squamous Cell Skin Carcinoma:



Diseases related to Sarcomatoid Squamous Cell Skin Carcinoma

Symptoms & Phenotypes for Sarcomatoid Squamous Cell Skin Carcinoma

Drugs & Therapeutics for Sarcomatoid Squamous Cell Skin Carcinoma

Search Clinical Trials , NIH Clinical Center for Sarcomatoid Squamous Cell Skin Carcinoma

Genetic Tests for Sarcomatoid Squamous Cell Skin Carcinoma

Anatomical Context for Sarcomatoid Squamous Cell Skin Carcinoma

MalaCards organs/tissues related to Sarcomatoid Squamous Cell Skin Carcinoma:

40
Skin, Breast, Bone, Heart, Liver, Lung, Skeletal Muscle

Publications for Sarcomatoid Squamous Cell Skin Carcinoma

Articles related to Sarcomatoid Squamous Cell Skin Carcinoma:

(show top 50) (show all 63)
# Title Authors PMID Year
1
Cutaneous Spindle Cell Squamous Cell Carcinoma in Cats: Clinical, Histological, and Immunohistochemical Study. 61
33577428 2021
2
Primary Cutaneous Myxoid Spindle Cell Squamous Cell Carcinoma of the Scalp: A Case Report. 61
32701165 2021
3
Clinicopathological and Prognostic Characteristics of Esophageal Spindle Cell Squamous Cell Carcinoma: An Analysis of 43 Patients in a Single Center. 61
33777730 2021
4
Irradiated Skeletal Muscle Cells Mimicking Those of Atypical Fibroxanthoma on Mohs Frozen Sections. 61
32956095 2020
5
A genomic survey of sarcomas on sun-exposed skin reveals distinctive candidate drivers and potentially targetable mutations. 61
32540221 2020
6
A spindle cell squamous cell carcinoma on the cheek presenting with in-transit metastases and a satellite lesion. 61
32126623 2020
7
Unusual Presentation of Cutaneous Spindle Cell Squamous Cell Carcinoma: A Case Report. 61
32355488 2020
8
Laryngeal Basaloid Squamous Cell Carcinoma with a Substantial Spindle Cell Component: Case Presentation and Updated Review of Literature. 61
29869750 2019
9
Malignant Chondroid Syringoma: A Report of Two Cases with a Sarcomatous Mesenchymal Component. 61
31700847 2019
10
Clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare case. 61
30785474 2019
11
Prolonged Response to Pembrolizumab in Spindle Cell Squamous Cell Carcinoma Metastatic to the Central Nervous System. 61
31132886 2019
12
Pseudomyogenic Hemangioendothelioma. 61
31130564 2019
13
Carcinosarcomas of the esophagus: systematic review of a rare nosologic entity. 61
30570870 2018
14
A tale of two clones: Caldesmon staining in the differentiation of cutaneous spindle cell neoplasms. 61
29687929 2018
15
Summary of expression of SPARC protein in cutaneous vascular neoplasms and mimickers. 61
29660567 2018
16
Microphthalmia-associated transcription factor (MiTF): Promiscuous staining patterns in fibrohistiocytic lesions is a potential pitfall. 61
29773427 2018
17
Myoepithelial carcinoma of the tongue- spindle cell morphology with high mitosis: A case report and review of literature. 61
29323073 2017
18
Spindle cell squamous cell carcinoma arising in Bowen's disease: Case report and review of the published work. 61
28370387 2017
19
Sarcomatoid Squamous Cell Carcinoma of the Penis - a Report of Two Cases. 61
28704194 2017
20
FOSB is a Useful Diagnostic Marker for Pseudomyogenic Hemangioendothelioma. 61
28009608 2017
21
Squamous cell carcinoma of the upper aerodigestive tract: dysplasia and select variants. 61
28060368 2017
22
Case of spindle cell squamous cell carcinoma with dermoscopic findings of diffuse/discrete scales and predominant white color. 61
27075812 2016
23
Spindle cell squamous cell carcinoma arising from chronic osteomyelitis. 61
26590122 2016
24
Primary cutaneous myxoid spindle cell squamous cell carcinoma: a rare skin cancer. 61
26472290 2015
25
Spindle cell squamous cell carcinoma arising from verrucous hyperplasia during BRAF inhibitor therapy for melanoma. 61
25761417 2015
26
Cutaneous spindle cell squamous cell carcinoma. 61
25673951 2015
27
p40 is more specific than p63 for the distinction of atypical fibroxanthoma from other cutaneous spindle cell malignancies. 61
25029117 2014
28
An unusual presentation of an aggressive spindle cell skin cancer. 61
24971424 2014
29
The transcription factor Snail expressed in cutaneous squamous cell carcinoma induces epithelial-mesenchymal transition and down-regulates COX-2. 61
23261444 2013
30
Cutaneous basal cell carcinoma with dual differentiation into squamous cell carcinoma and spindle cell squamous cell carcinoma: a case report with immunohistochemical studies. 61
23227812 2013
31
Anti-cytokeratin CAM5.2 should not be mistaken for cytokeratin 8/18 monoclonal antibody: comment on "spindle cell squamous cell carcinoma not expressing stratified but simple epithelial cytokeratin: Efficacy of simple epithelial cytokeratin immunoreactivity" (Tokuriki A, Kiyohara T, Kouraba S, Kumakiri M, Journal of Dermatology 2012; 39: 72-75). 61
22963005 2012
32
Spindle cell neoplasms encountered in dermatologic surgery: a review. 61
22268379 2012
33
P75 nerve growth factor receptor as a useful marker to distinguish spindle cell melanoma from other spindle cell neoplasms of sun-damaged skin. 61
22207443 2012
34
Spindle cell squamous cell carcinoma not expressing stratified but simple epithelial cytokeratin: efficacy of simple epithelial cytokeratin immunoreactivity. 61
21954987 2012
35
The role of CD10 in distinguishing atypical fibroxanthoma from sarcomatoid (spindle cell) squamous cell carcinoma. 61
21883368 2011
36
Clinical and pathologic predictors of recurrence and survival in spindle cell squamous cell carcinoma. 61
21493284 2011
37
Laryngeal spindle cell squamous cell carcinoma. 61
21563088 2011
38
Cutaneous spindle cell squamous cell carcinoma in nevus sebaceous. 61
21091681 2010
39
Anti-cytokeratin CAM 5.2 does not act as a surrogate of the cytokeratin 8/18 monoclonal antibody. Comment on: "Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma", in J Cutan Pathol 2009; 36: 543. 61
20175827 2010
40
CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma. 61
20184665 2010
41
Desmoplastic/spindle cell squamous cell carcinoma of the skin. A diagnostically challenging tumor mimicking a scar: clinicopathologic and immunohistochemical study of 6 cases. 61
20514676 2010
42
Primary cutaneous myxoid spindle cell squamous cell carcinoma: a clinicopathologic study and review of the literature. 61
19811587 2010
43
Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma. 61
19476522 2009
44
Procollagen 1 and Melan-A expression in desmoplastic melanomas. 61
19318805 2009
45
Spindle cell squamous cell carcinoma showing epithelial-mesenchymal transition. 61
18482319 2009
46
Sarcomatoid squamous cell carcinoma: a long-standing case. 61
19104745 2008
47
Expression of OCT4 transcription factor in cutaneous neoplasia. 61
18091376 2007
48
Spindle cell neoplasm of skin: diagnostic dilemma. 61
18306566 2007
49
p63 is a useful marker for cutaneous spindle cell squamous cell carcinoma. 61
16776716 2006
50
Spindle cell squamous cell carcinoma showing continuous mesenchymal dedifferentiation in a single tumor. 61
16361733 2005

Variations for Sarcomatoid Squamous Cell Skin Carcinoma

Expression for Sarcomatoid Squamous Cell Skin Carcinoma

Search GEO for disease gene expression data for Sarcomatoid Squamous Cell Skin Carcinoma.

Pathways for Sarcomatoid Squamous Cell Skin Carcinoma

Pathways related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.86 MME CD68 CD34

GO Terms for Sarcomatoid Squamous Cell Skin Carcinoma

Cellular components related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT8 KRT5 KRT34

Biological processes related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.46 SERPINA3 PECAM1 MME CD68
2 keratinization GO:0031424 9.43 KRT8 KRT5 KRT34
3 cornification GO:0070268 9.13 KRT8 KRT5 KRT34
4 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Sources for Sarcomatoid Squamous Cell Skin Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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