MCID: SRC008
MIFTS: 30

Sarcomatoid Squamous Cell Skin Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Sarcomatoid Squamous Cell Skin Carcinoma

MalaCards integrated aliases for Sarcomatoid Squamous Cell Skin Carcinoma:

Name: Sarcomatoid Squamous Cell Skin Carcinoma 12 15
Spindle Cell Squamous Cell Carcinoma 12 74
Spindle Cell Squamous Cell Skin Carcinoma 12
Spindle Cell Squamous Carcinoma of Skin 12
Spindle Cell Squamous Cell Carcinoma 12
Squamous Cell Carcinoma, Sarcomatoid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5536
NCIt 51 C27084 C4666
SNOMED-CT 69 10288008
UMLS 74 C0349656

Summaries for Sarcomatoid Squamous Cell Skin Carcinoma

MalaCards based summary : Sarcomatoid Squamous Cell Skin Carcinoma, also known as spindle cell squamous cell carcinoma, is related to squamous cell carcinoma and melanoma. An important gene associated with Sarcomatoid Squamous Cell Skin Carcinoma is CAMTA1 (Calmodulin Binding Transcription Activator 1), and among its related pathways/superpathways are Keratinization and Primary Focal Segmental Glomerulosclerosis FSGS. Affiliated tissues include skin and tongue, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Sarcomatoid Squamous Cell Skin Carcinoma

Diseases related to Sarcomatoid Squamous Cell Skin Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 10.7
2 melanoma 10.2
3 mucinous tubular and spindle renal cell carcinoma 10.1 KRT8 MME
4 balloon cell malignant melanoma 10.0 KRT5 MME
5 apocrine sweat gland neoplasm 10.0 KRT5 KRT8
6 small cell carcinoma 10.0
7 cervical clear cell adenocarcinoma 10.0 KRT5 KRT8
8 nephrogenic adenofibroma 10.0 KRT8 MME
9 odontoma 10.0 KRT5 KRT8
10 prostate squamous cell carcinoma 10.0 KRT5 KRT8
11 breast adenomyoepithelioma 10.0 KRT5 MME
12 basal cell carcinoma 1 10.0
13 osteomyelitis 10.0
14 basal cell carcinoma 10.0
15 skin carcinoma 10.0
16 bowen's disease 10.0
17 breast myoepithelial neoplasm 10.0 KRT5 MME
18 lymphoepithelioma-like carcinoma 10.0 KRT5 KRT8
19 breast benign neoplasm 10.0 KRT5 MME
20 breast fibroadenoma 10.0 KRT8 MME
21 thoracic benign neoplasm 10.0 KRT5 MME
22 eccrine sweat gland neoplasm 10.0 KRT5 MME
23 cystadenofibroma 10.0 KRT5 MME
24 nasal cavity squamous cell carcinoma 10.0 KRT5 KRT8
25 atypical choroid plexus papilloma 10.0 KRT5 KRT8
26 breast secretory carcinoma 10.0 KRT5 KRT8
27 pregnancy adenoma 10.0 KRT5 KRT8
28 intraneural perineurioma 10.0 KRT5 KRT8
29 primary cutaneous amyloidosis 9.9 KRT5 KRT8
30 oncocytoma 9.9 KRT8 MME
31 adenosquamous carcinoma 9.9 KRT5 KRT8
32 chromophobe renal cell carcinoma 9.9 KRT8 MME
33 sweat gland cancer 9.9 KRT5 KRT8
34 ichthyosis 9.9 KRT1 KRT5
35 ichthyosis hystrix, curth-macklin type 9.9 KRT1 KRT5
36 leukoplakia 9.9 KRT1 KRT8
37 epithelioid sarcoma 9.8 KRT1 KRT8
38 ductal carcinoma in situ 9.8 KRT5 KRT8
39 osteofibrous dysplasia 9.8 KRT1 KRT5
40 skin benign neoplasm 9.8 KRT1 KRT5
41 palmoplantar keratosis 9.7 KRT1 KRT5
42 epidermolysis bullosa simplex 9.7 KRT1 KRT5
43 cholangiocarcinoma 9.7 KRT8 MME
44 epidermolytic hyperkeratosis 9.6 KRT1 KRT5
45 papilloma 9.6 KRT1 KRT5 KRT8

Graphical network of the top 20 diseases related to Sarcomatoid Squamous Cell Skin Carcinoma:



Diseases related to Sarcomatoid Squamous Cell Skin Carcinoma

Symptoms & Phenotypes for Sarcomatoid Squamous Cell Skin Carcinoma

GenomeRNAi Phenotypes related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

27 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.61 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.61 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.61 KRT5 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.61 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.61 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.61 KRT5 KRT8
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.61 KRT5
8 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.36 KRT5
9 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.36 KRT1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.36 KRT1 KRT5
11 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.36 KRT1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.36 KRT1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-172 9.36 KRT1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.36 KRT5
15 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.36 KRT1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.36 KRT1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.36 KRT1

Drugs & Therapeutics for Sarcomatoid Squamous Cell Skin Carcinoma

Search Clinical Trials , NIH Clinical Center for Sarcomatoid Squamous Cell Skin Carcinoma

Genetic Tests for Sarcomatoid Squamous Cell Skin Carcinoma

Anatomical Context for Sarcomatoid Squamous Cell Skin Carcinoma

MalaCards organs/tissues related to Sarcomatoid Squamous Cell Skin Carcinoma:

42
Skin, Tongue

Publications for Sarcomatoid Squamous Cell Skin Carcinoma

Articles related to Sarcomatoid Squamous Cell Skin Carcinoma:

(show all 24)
# Title Authors Year
1
Clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare case. ( 30785474 )
2019
2
Spindle cell squamous cell carcinoma arising in Bowen's disease: Case report and review of the published work. ( 28370387 )
2017
3
Spindle cell squamous cell carcinoma arising from chronic osteomyelitis. ( 26590122 )
2016
4
Case of spindle cell squamous cell carcinoma with dermoscopic findings of diffuse/discrete scales and predominant white color. ( 27075812 )
2016
5
Primary cutaneous myxoid spindle cell squamous cell carcinoma: a rare skin cancer. ( 26472290 )
2015
6
Cutaneous spindle cell squamous cell carcinoma. ( 25673951 )
2015
7
Spindle cell squamous cell carcinoma arising from verrucous hyperplasia during BRAF inhibitor therapy for melanoma. ( 25761417 )
2015
8
Cutaneous basal cell carcinoma with dual differentiation into squamous cell carcinoma and spindle cell squamous cell carcinoma: a case report with immunohistochemical studies. ( 23227812 )
2013
9
Spindle cell squamous cell carcinoma not expressing stratified but simple epithelial cytokeratin: efficacy of simple epithelial cytokeratin immunoreactivity. ( 21954987 )
2012
10
Anti-cytokeratin CAM5.2 should not be mistaken for cytokeratin 8/18 monoclonal antibody: comment on "spindle cell squamous cell carcinoma not expressing stratified but simple epithelial cytokeratin: Efficacy of simple epithelial cytokeratin immunoreactivity" (Tokuriki A, Kiyohara T, Kouraba S, Kumakiri M, Journal of Dermatology 2012; 39: 72-75). ( 22963005 )
2012
11
The role of CD10 in distinguishing atypical fibroxanthoma from sarcomatoid (spindle cell) squamous cell carcinoma. ( 21883368 )
2011
12
Clinical and pathologic predictors of recurrence and survival in spindle cell squamous cell carcinoma. ( 21493284 )
2011
13
Laryngeal spindle cell squamous cell carcinoma. ( 21563088 )
2011
14
CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma. ( 20184665 )
2010
15
Cutaneous spindle cell squamous cell carcinoma in nevus sebaceous. ( 21091681 )
2010
16
Primary cutaneous myxoid spindle cell squamous cell carcinoma: a clinicopathologic study and review of the literature. ( 19811587 )
2010
17
Anti-cytokeratin CAM 5.2 does not act as a surrogate of the cytokeratin 8/18 monoclonal antibody. Comment on: "Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma", in J Cutan Pathol 2009; 36: 543. ( 20175827 )
2010
18
Desmoplastic/spindle cell squamous cell carcinoma of the skin. A diagnostically challenging tumor mimicking a scar: clinicopathologic and immunohistochemical study of 6 cases. ( 20514676 )
2010
19
Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma. ( 19476522 )
2009
20
Spindle cell squamous cell carcinoma showing epithelial-mesenchymal transition. ( 18482319 )
2009
21
p63 is a useful marker for cutaneous spindle cell squamous cell carcinoma. ( 16776716 )
2006
22
Spindle cell squamous cell carcinoma showing continuous mesenchymal dedifferentiation in a single tumor. ( 16361733 )
2005
23
Metaplastic breast carcinoma histologically mimicking cutaneous spindle cell squamous cell carcinoma. ( 15900133 )
2005
24
The utility of cytokeratin 5/6 in the recognition of cutaneous spindle cell squamous cell carcinoma. ( 11737521 )
2001

Variations for Sarcomatoid Squamous Cell Skin Carcinoma

Expression for Sarcomatoid Squamous Cell Skin Carcinoma

Search GEO for disease gene expression data for Sarcomatoid Squamous Cell Skin Carcinoma.

Pathways for Sarcomatoid Squamous Cell Skin Carcinoma

Pathways related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.59 KRT1 KRT5 KRT8
2 11.02 KRT8 MME
3
Show member pathways
10.83 KRT1 KRT5 KRT8

GO Terms for Sarcomatoid Squamous Cell Skin Carcinoma

Cellular components related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.46 KRT1 KRT5 KRT8 MME
2 intermediate filament GO:0005882 9.13 KRT1 KRT5 KRT8
3 keratin filament GO:0045095 8.8 KRT1 KRT5 KRT8

Biological processes related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.13 KRT1 KRT5 KRT8
2 cornification GO:0070268 8.8 KRT1 KRT5 KRT8

Molecular functions related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.62 KRT5 KRT8

Sources for Sarcomatoid Squamous Cell Skin Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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