MCID: SRC008
MIFTS: 35

Sarcomatoid Squamous Cell Skin Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Sarcomatoid Squamous Cell Skin Carcinoma

MalaCards integrated aliases for Sarcomatoid Squamous Cell Skin Carcinoma:

Name: Sarcomatoid Squamous Cell Skin Carcinoma 12 15
Spindle Cell Squamous Cell Carcinoma 12 73
Spindle Cell Squamous Cell Skin Carcinoma 12
Spindle Cell Squamous Carcinoma of Skin 12
Spindle Cell Squamous Cell Carcinoma 12
Squamous Cell Carcinoma, Sarcomatoid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5536
NCIt 50 C27084 C4666
SNOMED-CT 68 10288008
UMLS 73 C0349656

Summaries for Sarcomatoid Squamous Cell Skin Carcinoma

MalaCards based summary : Sarcomatoid Squamous Cell Skin Carcinoma, also known as spindle cell squamous cell carcinoma, is related to basal cell carcinoma and squamous cell carcinoma. An important gene associated with Sarcomatoid Squamous Cell Skin Carcinoma is CAMTA1 (Calmodulin Binding Transcription Activator 1), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include skin, brain and liver, and related phenotypes are growth/size/body region and integument

Related Diseases for Sarcomatoid Squamous Cell Skin Carcinoma

Diseases related to Sarcomatoid Squamous Cell Skin Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 basal cell carcinoma 29.9 CD34 KRT5 KRT8 MME
2 squamous cell carcinoma 10.7
3 ichthyosis hystrix, curth-macklin type 10.3 KRT1 KRT5
4 apocrine sweat gland neoplasm 10.3 KRT5 KRT8
5 proliferative fasciitis 10.3 CAMTA1 MB
6 fallopian tube adenocarcinoma 10.2 MAPK8IP1 MME
7 cervical clear cell adenocarcinoma 10.2 KRT5 KRT8
8 malignant spindle cell melanoma 10.2 MITF NGFR
9 odontoma 10.2 KRT5 KRT8
10 malignant leydig cell tumor 10.2 MME POU5F1
11 prostate squamous cell carcinoma 10.2 KRT5 KRT8
12 gallbladder melanoma 10.2 MITF MLANA
13 epithelioid hemangioendothelioma 10.2 CAMTA1 TFE3
14 large cell acanthoma 10.2 KRT5 MLANA
15 cervical carcinosarcoma 10.2 MAPK8IP1 MME
16 breast fibroadenoma 10.2 KRT8 MME NGFR
17 lentigo maligna melanoma 10.2 MITF MLANA
18 pleomorphic rhabdomyosarcoma 10.2 MB MME
19 papilloma 10.2 KRT1 KRT5 KRT8
20 anal canal squamous cell carcinoma 10.2 KRT5 MAPK8IP1
21 epithelioid sarcoma 10.2 KRT1 KRT8 MB
22 breast adenomyoepithelioma 10.2 KRT5 MME
23 epithelioid cell melanoma 10.2 MITF MLANA
24 nasal cavity squamous cell carcinoma 10.2 KRT5 KRT8 MLANA
25 breast myoepithelial neoplasm 10.2 KRT5 MME
26 mixed cell type cancer 10.2 MB MME POU5F1
27 giant cell myocarditis 10.2 CD68 MB
28 melanoma 10.2
29 mixed endometrial stromal and smooth muscle tumor 10.2 CALD1 MME
30 virus associated hemophagocytic syndrome 10.1 CD68 MB
31 lung combined type small cell carcinoma 10.1 CALD1 MME
32 infiltrative basal cell carcinoma 10.1 MLANA MME NGFR
33 cervical adenoma malignum 10.1 CALD1 MME
34 adenosarcoma 10.1 MB MME
35 t-cell/histiocyte rich large b cell lymphoma 10.1 CD68 MME
36 cervical mucinous adenocarcinoma 10.1 CALD1 MME
37 pregnancy adenoma 10.1 CD68 KRT5 KRT8
38 melanoma, uveal 10.1 KRT8 MITF MLANA
39 mucinous tubular and spindle renal cell carcinoma 10.1 KRT8 MME TFE3
40 brain sarcoma 10.1 CD68 MLANA
41 clear cell papillary renal cell carcinoma 10.1 MITF MME TFE3
42 lymphoepithelioma-like carcinoma 10.1 KRT5 KRT8
43 pigmented basal cell carcinoma 10.1 FOXO4 MITF MLANA
44 diffuse meningeal melanocytosis 10.1 CD68 MLANA
45 renal cell carcinoma, papillary, 1 10.1 MITF MME TFE3
46 ovarian melanoma 10.1 CALD1 MLANA
47 invasive malignant thymoma 10.1 CD34 MME
48 psammomatous meningioma 10.1 CD34 MME
49 endometrial stromal nodule 10.0 CALD1 MME
50 conventional angiosarcoma 10.0 CAMTA1 CD34

Graphical network of the top 20 diseases related to Sarcomatoid Squamous Cell Skin Carcinoma:



Diseases related to Sarcomatoid Squamous Cell Skin Carcinoma

Symptoms & Phenotypes for Sarcomatoid Squamous Cell Skin Carcinoma

MGI Mouse Phenotypes related to Sarcomatoid Squamous Cell Skin Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.9 CAMTA1 FOSB KRT1 KRT5 KRT8 MAPK8IP1
2 integument MP:0010771 9.61 CD34 KRT1 KRT5 MITF MLANA MME
3 mortality/aging MP:0010768 9.4 CAMTA1 FOXO4 KRT1 KRT5 KRT8 MAPK8IP1

Drugs & Therapeutics for Sarcomatoid Squamous Cell Skin Carcinoma

Search Clinical Trials , NIH Clinical Center for Sarcomatoid Squamous Cell Skin Carcinoma

Genetic Tests for Sarcomatoid Squamous Cell Skin Carcinoma

Anatomical Context for Sarcomatoid Squamous Cell Skin Carcinoma

MalaCards organs/tissues related to Sarcomatoid Squamous Cell Skin Carcinoma:

41
Skin, Brain, Liver, Spleen, Smooth Muscle, Thymus, Retina

Publications for Sarcomatoid Squamous Cell Skin Carcinoma

Articles related to Sarcomatoid Squamous Cell Skin Carcinoma:

(show all 23)
# Title Authors Year
1
Spindle cell squamous cell carcinoma arising in Bowen's disease: Case report and review of the published work. ( 28370387 )
2017
2
Spindle cell squamous cell carcinoma arising from chronic osteomyelitis. ( 26590122 )
2016
3
Case of spindle cell squamous cell carcinoma with dermoscopic findings of diffuse/discrete scales and predominant white color. ( 27075812 )
2016
4
Cutaneous spindle cell squamous cell carcinoma. ( 25673951 )
2015
5
Spindle cell squamous cell carcinoma arising from verrucous hyperplasia during BRAF inhibitor therapy for melanoma. ( 25761417 )
2015
6
Primary cutaneous myxoid spindle cell squamous cell carcinoma: a rare skin cancer. ( 26472290 )
2015
7
Cutaneous basal cell carcinoma with dual differentiation into squamous cell carcinoma and spindle cell squamous cell carcinoma: a case report with immunohistochemical studies. ( 23227812 )
2013
8
Spindle cell squamous cell carcinoma not expressing stratified but simple epithelial cytokeratin: efficacy of simple epithelial cytokeratin immunoreactivity. ( 21954987 )
2012
9
Anti-cytokeratin CAM5.2 should not be mistaken for cytokeratin 8/18 monoclonal antibody: comment on "spindle cell squamous cell carcinoma not expressing stratified but simple epithelial cytokeratin: Efficacy of simple epithelial cytokeratin immunoreactivity" (Tokuriki A, Kiyohara T, Kouraba S, Kumakiri M, Journal of Dermatology 2012; 39: 72-75). ( 22963005 )
2012
10
The role of CD10 in distinguishing atypical fibroxanthoma from sarcomatoid (spindle cell) squamous cell carcinoma. ( 21883368 )
2011
11
Clinical and pathologic predictors of recurrence and survival in spindle cell squamous cell carcinoma. ( 21493284 )
2011
12
Laryngeal spindle cell squamous cell carcinoma. ( 21563088 )
2011
13
CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma. ( 20184665 )
2010
14
Cutaneous spindle cell squamous cell carcinoma in nevus sebaceous. ( 21091681 )
2010
15
Desmoplastic/spindle cell squamous cell carcinoma of the skin. A diagnostically challenging tumor mimicking a scar: clinicopathologic and immunohistochemical study of 6 cases. ( 20514676 )
2010
16
Primary cutaneous myxoid spindle cell squamous cell carcinoma: a clinicopathologic study and review of the literature. ( 19811587 )
2010
17
Anti-cytokeratin CAM 5.2 does not act as a surrogate of the cytokeratin 8/18 monoclonal antibody. Comment on: "Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma", in J Cutan Pathol 2009; 36: 543. ( 20175827 )
2010
18
Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma. ( 19476522 )
2009
19
Spindle cell squamous cell carcinoma showing epithelial-mesenchymal transition. ( 18482319 )
2009
20
p63 is a useful marker for cutaneous spindle cell squamous cell carcinoma. ( 16776716 )
2006
21
Spindle cell squamous cell carcinoma showing continuous mesenchymal dedifferentiation in a single tumor. ( 16361733 )
2005
22
Metaplastic breast carcinoma histologically mimicking cutaneous spindle cell squamous cell carcinoma. ( 15900133 )
2005
23
The utility of cytokeratin 5/6 in the recognition of cutaneous spindle cell squamous cell carcinoma. ( 11737521 )
2001

Variations for Sarcomatoid Squamous Cell Skin Carcinoma

Expression for Sarcomatoid Squamous Cell Skin Carcinoma

Search GEO for disease gene expression data for Sarcomatoid Squamous Cell Skin Carcinoma.

Pathways for Sarcomatoid Squamous Cell Skin Carcinoma

Pathways related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 CD34 CD68 MME
2
Show member pathways
11.17 KRT1 KRT5 KRT8
3 11.05 MITF NGFR POU5F1 SNAI1

GO Terms for Sarcomatoid Squamous Cell Skin Carcinoma

Cellular components related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.4 CALD1 CAMTA1 FOXO4 KRT1 KRT5 KRT8
2 keratin filament GO:0045095 9.13 KRT1 KRT5 KRT8

Biological processes related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.73 CAMTA1 FOSB FOXO4 MITF POU5F1 TFE3
2 cornification GO:0070268 9.33 KRT1 KRT5 KRT8
3 transcription by RNA polymerase II GO:0006366 9.1 CAMTA1 FOSB FOXO4 MITF POU5F1 TFE3
4 regulation of osteoclast differentiation GO:0045670 8.96 MITF TFE3

Molecular functions related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.55 CAMTA1 FOSB FOXO4 POU5F1 SNAI1
2 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 9.43 MITF POU5F1 SNAI1
3 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 9.26 CAMTA1 FOSB MITF TFE3
4 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.17 CAMTA1 FOSB FOXO4 MITF POU5F1 SNAI1

Sources for Sarcomatoid Squamous Cell Skin Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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