MCID: SRC008
MIFTS: 31

Sarcomatoid Squamous Cell Skin Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Sarcomatoid Squamous Cell Skin Carcinoma

MalaCards integrated aliases for Sarcomatoid Squamous Cell Skin Carcinoma:

Name: Sarcomatoid Squamous Cell Skin Carcinoma 12 15
Spindle Cell Squamous Cell Carcinoma 12 73
Spindle Cell Squamous Cell Skin Carcinoma 12
Spindle Cell Squamous Carcinoma of Skin 12
Spindle Cell Squamous Cell Carcinoma 12
Squamous Cell Carcinoma, Sarcomatoid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5536
NCIt 50 C27084 C4666
UMLS 73 C0349656

Summaries for Sarcomatoid Squamous Cell Skin Carcinoma

MalaCards based summary : Sarcomatoid Squamous Cell Skin Carcinoma, also known as spindle cell squamous cell carcinoma, is related to kidney rhabdoid cancer and malignant spiradenoma. An important gene associated with Sarcomatoid Squamous Cell Skin Carcinoma is MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Innate Lymphoid Cell Differentiation Pathways. Affiliated tissues include skin, and related phenotypes are cellular and neoplasm

Related Diseases for Sarcomatoid Squamous Cell Skin Carcinoma

Diseases related to Sarcomatoid Squamous Cell Skin Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 kidney rhabdoid cancer 10.6 MB PTPRC
2 malignant spiradenoma 10.5 KRT5 TP53
3 immune system organ benign neoplasm 10.5 MB PTPRC
4 vulvar intraepithelial neoplasia 10.5 KRT5 TP53
5 thymus lipoma 10.5 MB PTPRC
6 fallopian tube adenocarcinoma 10.5 MAPK8IP1 TP53
7 keratinizing squamous cell carcinoma 10.5 KRT5 TP53
8 cervical carcinosarcoma 10.5 MAPK8IP1 TP53
9 cloacogenic carcinoma 10.5 KRT5 PTPRC
10 dowling-degos disease 1 10.5 KIT KRT5
11 endometrial small cell carcinoma 10.5 KIT PTPRC
12 testicular infarct 10.5 KIT PTPRC
13 breast squamous cell carcinoma 10.5 KRT5 TP53
14 dysgerminoma of ovary 10.5 KIT MAPK8IP1
15 schneiderian carcinoma 10.5 KRT5 TP53
16 cervix small cell carcinoma 10.4 MAPK8IP1 TP53
17 prostate squamous cell carcinoma 10.4 KRT5 TP53
18 liver inflammatory pseudotumor 10.4 CD34 PTPRC
19 extraosseous osteosarcoma 10.4 CD34 PTPRC
20 vulvar sarcoma 10.4 CD34 PTPRC
21 pleuropulmonary blastoma 10.4 MB TP53
22 chronic monocytic leukemia 10.4 CD34 PTPRC
23 gallbladder leiomyoma 10.4 CD34 KIT
24 lung leiomyosarcoma 10.4 CD34 KIT
25 liver leiomyoma 10.4 CD34 KIT
26 deep leiomyoma 10.4 CD34 KIT
27 small intestine leiomyosarcoma 10.4 CD34 KIT
28 small intestinal sarcoma 10.4 CD34 KIT
29 gallbladder sarcoma 10.4 CD34 KIT
30 prostate leiomyosarcoma 10.4 CD34 KIT
31 optic nerve neoplasm 10.4 KRT5 TP53
32 gastric leiomyosarcoma 10.4 CD34 KIT
33 pigmented villonodular synovitis 10.4 PTPRC TP53
34 breast angiosarcoma 10.4 CD34 KIT
35 myeloid sarcoma 10.3 KIT PTPRC
36 plexiform schwannoma 10.3 CD34 KIT
37 uterine body mixed cancer 10.3 KIT TP53
38 hidradenocarcinoma 10.3 KRT5 TP53
39 intraneural perineurioma 10.3 CD34 KRT5
40 senile angioma 10.3 CD34 KIT
41 squamous cell carcinoma 10.3
42 spindle cell liposarcoma 10.3 CD34 KIT
43 cellular neurofibroma 10.3 CD34 TP53
44 pleomorphic carcinoma 10.3 KIT TP53
45 mesenchymal cell neoplasm 10.3 CD34 KIT
46 uterine sarcoma 10.3 KIT MB
47 cervix carcinoma 10.3 MAPK8IP1 TP53
48 cardiovascular organ benign neoplasm 10.3 CD34 MB
49 pre-malignant neoplasm 10.3 KRT5 TP53
50 medullomyoblastoma 10.3 MB TP53

Graphical network of the top 20 diseases related to Sarcomatoid Squamous Cell Skin Carcinoma:



Diseases related to Sarcomatoid Squamous Cell Skin Carcinoma

Symptoms & Phenotypes for Sarcomatoid Squamous Cell Skin Carcinoma

MGI Mouse Phenotypes related to Sarcomatoid Squamous Cell Skin Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.7 CD34 FOXO4 KIT MAPK8IP1 MB PTPRC
2 neoplasm MP:0002006 9.35 FOXO4 KIT PTPRC TP53 CD34
3 no phenotypic analysis MP:0003012 9.02 CD68 KIT KRT5 PTPRC TP53

Drugs & Therapeutics for Sarcomatoid Squamous Cell Skin Carcinoma

Search Clinical Trials , NIH Clinical Center for Sarcomatoid Squamous Cell Skin Carcinoma

Genetic Tests for Sarcomatoid Squamous Cell Skin Carcinoma

Anatomical Context for Sarcomatoid Squamous Cell Skin Carcinoma

MalaCards organs/tissues related to Sarcomatoid Squamous Cell Skin Carcinoma:

41
Skin

Publications for Sarcomatoid Squamous Cell Skin Carcinoma

Articles related to Sarcomatoid Squamous Cell Skin Carcinoma:

# Title Authors Year
1
Spindle cell squamous cell carcinoma arising in Bowen's disease: Case report and review of the published work. ( 28370387 )
2017
2
Cutaneous basal cell carcinoma with dual differentiation into squamous cell carcinoma and spindle cell squamous cell carcinoma: a case report with immunohistochemical studies. ( 23227812 )
2013
3
The role of CD10 in distinguishing atypical fibroxanthoma from sarcomatoid (spindle cell) squamous cell carcinoma. ( 21883368 )
2011
4
CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma. ( 20184665 )
2010
5
Cutaneous spindle cell squamous cell carcinoma in nevus sebaceous. ( 21091681 )
2010
6
Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma. ( 19476522 )
2009
7
p63 is a useful marker for cutaneous spindle cell squamous cell carcinoma. ( 16776716 )
2006
8
Spindle cell squamous cell carcinoma showing continuous mesenchymal dedifferentiation in a single tumor. ( 16361733 )
2005

Variations for Sarcomatoid Squamous Cell Skin Carcinoma

Cosmic variations for Sarcomatoid Squamous Cell Skin Carcinoma:

9
(show top 50) (show all 360)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM11183 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.799C>T p.R267W 17:7673821-7673821 14
2 COSM10705 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.586C>T p.R196* 17:7674945-7674945 14
3 COSM43753 TP53 skin,lower leg,carcinoma,squamous cell carcinoma c.560-1G>A p.? 17:7674972-7674972 14
4 COSM44135 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.724T>G p.C242G 17:7674239-7674239 14
5 COSM44218 TP53 skin,lower leg,carcinoma,squamous cell carcinoma c.536A>C p.H179P 17:7675076-7675076 14
6 COSM10863 TP53 skin,lower leg,carcinoma,squamous cell carcinoma c.833C>T p.P278L 17:7673787-7673787 14
7 COSM10889 TP53 skin,lower leg,carcinoma,squamous cell carcinoma c.536A>G p.H179R 17:7675076-7675076 14
8 COSM44495 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.559+2T>A p.? 17:7675051-7675051 14
9 COSM10726 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.856G>A p.E286K 17:7673764-7673764 14
10 COSM44523 TP53 skin,lower leg,carcinoma,squamous cell carcinoma c.863A>G p.N288S 17:7673757-7673757 14
11 COSM10659 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.817C>T p.R273C 17:7673803-7673803 14
12 COSM44544 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.766A>G p.T256A 17:7674197-7674197 14
13 COSM10662 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 14
14 COSM11066 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.578A>T p.H193L 17:7674953-7674953 14
15 COSM6903923 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.356C>T p.A119V 17:7676013-7676013 14
16 COSM10731 TP53 skin,lower leg,carcinoma,squamous cell carcinoma c.707A>G p.Y236C 17:7674256-7674256 14
17 COSM43952 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.710T>A p.M237K 17:7674253-7674253 14
18 COSM44023 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.560G>A p.G187D 17:7674971-7674971 14
19 COSM44151 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.535C>A p.H179N 17:7675077-7675077 14
20 COSM43544 TP53 skin,lower leg,carcinoma,squamous cell carcinoma c.260C>A p.P87Q 17:7676109-7676109 14
21 COSM10812 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.722C>T p.S241F 17:7674241-7674241 14
22 COSM10648 TP53 skin,lower leg,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 14
23 COSM44393 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.821T>C p.V274A 17:7673799-7673799 14
24 COSM11451 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.672G>T p.E224D 17:7674859-7674859 14
25 COSM45765 TP53 skin,lower leg,carcinoma,squamous cell carcinoma c.987C>A p.T329T 17:7673541-7673541 14
26 COSM10654 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 14
27 COSM10725 TP53 skin,scalp,carcinoma,squamous cell carcinoma c.701A>G p.Y234C 17:7674262-7674262 14
28 COSM45114 TP53 skin,lower leg,carcinoma,squamous cell carcinoma c.702C>A p.Y234* 17:7674261-7674261 14
29 COSM43995 TP53 skin,lower leg,carcinoma,squamous cell carcinoma c.740A>T p.N247I 17:7674223-7674223 14
30 COSM6970765 PTPRD skin,scalp,carcinoma,squamous cell carcinoma c.2471C>T p.P824L 9:8486346-8486346 14
31 COSM163485 PIK3CA skin,scalp,carcinoma,squamous cell carcinoma c.311C>T p.P104L 3:179199136-179199136 14
32 COSM6903911 NRAS skin,scalp,carcinoma,squamous cell carcinoma c.332T>A p.M111K 1:114709687-114709687 14
33 COSM573 NRAS skin,scalp,carcinoma,squamous cell carcinoma c.38G>A p.G13D 1:114716123-114716123 14
34 COSM6903859 NOTCH2 skin,scalp,carcinoma,squamous cell carcinoma c.4358G>A p.G1453D 1:119925458-119925458 14
35 COSM6903876 NOTCH2 skin,lower leg,carcinoma,squamous cell carcinoma c.5449G>A p.D1817N 1:119920259-119920259 14
36 COSM6903874 NOTCH2 skin,scalp,carcinoma,squamous cell carcinoma c.5164A>G p.S1722G 1:119922285-119922285 14
37 COSM6903856 NOTCH2 skin,scalp,carcinoma,squamous cell carcinoma c.4006G>A p.G1336R 1:119925810-119925810 14
38 COSM6903890 NOTCH2 skin,scalp,carcinoma,squamous cell carcinoma c.5930G>A p.G1977E 1:119917762-119917762 14
39 COSM6903983 NOTCH2 skin,lower leg,carcinoma,squamous cell carcinoma c.3052A>G p.T1018A 1:119940686-119940686 14
40 COSM6903862 NOTCH2 skin,scalp,carcinoma,squamous cell carcinoma c.4509C>A p.C1503* 1:119925307-119925307 14
41 COSM6903883 NOTCH2 skin,scalp,carcinoma,squamous cell carcinoma c.5653G>A p.A1885T 1:119919440-119919440 14
42 COSM6903843 NOTCH2 skin,scalp,carcinoma,squamous cell carcinoma c.2891G>A p.C964Y 1:119941616-119941616 14
43 COSM6903868 NOTCH2 skin,scalp,carcinoma,squamous cell carcinoma c.4860-1G>A p.? 1:119922779-119922779 14
44 COSM6903878 NOTCH2 skin,scalp,carcinoma,squamous cell carcinoma c.5480A>T p.D1827V 1:119919613-119919613 14
45 COSM6903881 NOTCH2 skin,scalp,carcinoma,squamous cell carcinoma c.5630G>A p.G1877D 1:119919463-119919463 14
46 COSM6903864 NOTCH2 skin,lower leg,carcinoma,squamous cell carcinoma c.4570A>G p.S1524G 1:119923926-119923926 14
47 COSM6903831 NOTCH2 skin,scalp,carcinoma,squamous cell carcinoma c.1738C>T p.H580Y 1:119963751-119963751 14
48 COSM6903826 NOTCH2 skin,scalp,carcinoma,squamous cell carcinoma c.1319T>G p.F440C 1:119967567-119967567 14
49 COSM1667036 NOTCH2 skin,scalp,carcinoma,squamous cell carcinoma c.337C>T p.R113* 1:120005407-120005407 14
50 COSM6903863 NOTCH2 skin,scalp,carcinoma,squamous cell carcinoma c.4510A>G p.K1504E 1:119925306-119925306 14

Expression for Sarcomatoid Squamous Cell Skin Carcinoma

Search GEO for disease gene expression data for Sarcomatoid Squamous Cell Skin Carcinoma.

Pathways for Sarcomatoid Squamous Cell Skin Carcinoma

GO Terms for Sarcomatoid Squamous Cell Skin Carcinoma

Cellular components related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD34 KIT PTPRC

Biological processes related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell differentiation GO:0030217 9.16 KIT PTPRC
2 stem cell differentiation GO:0048863 8.96 FOXO4 KIT
3 positive regulation of cell cycle arrest GO:0071158 8.62 FOXO4 TP53

Molecular functions related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 promoter-specific chromatin binding GO:1990841 8.62 FOXO4 TP53

Sources for Sarcomatoid Squamous Cell Skin Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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