MCID: SRC008
MIFTS: 26

Sarcomatoid Squamous Cell Skin Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Sarcomatoid Squamous Cell Skin Carcinoma

MalaCards integrated aliases for Sarcomatoid Squamous Cell Skin Carcinoma:

Name: Sarcomatoid Squamous Cell Skin Carcinoma 12 15
Spindle Cell Squamous Cell Carcinoma 12 71
Spindle Cell Squamous Cell Skin Carcinoma 12
Spindle Cell Squamous Carcinoma of Skin 12
Spindle Cell Squamous Cell Carcinoma 12
Squamous Cell Carcinoma, Sarcomatoid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5536
NCIt 50 C27084
SNOMED-CT 67 403900000
UMLS 71 C0349656

Summaries for Sarcomatoid Squamous Cell Skin Carcinoma

MalaCards based summary : Sarcomatoid Squamous Cell Skin Carcinoma, also known as spindle cell squamous cell carcinoma, is related to leiomyosarcoma and keratosis, seborrheic. An important gene associated with Sarcomatoid Squamous Cell Skin Carcinoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include skin, tongue and skeletal muscle, and related phenotype is integument.

Related Diseases for Sarcomatoid Squamous Cell Skin Carcinoma

Diseases related to Sarcomatoid Squamous Cell Skin Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 294)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 30.5 SERPINA3 PECAM1 MLANA
2 keratosis, seborrheic 30.1 MLANA KRT5
3 cutaneous leiomyosarcoma 30.0 CD68 CD34 CALD1
4 basal cell carcinoma 29.9 MME KRT5 CD68 CD34
5 malignant spindle cell melanoma 29.8 SOX10 SERPINA3 MLANA CD68 CD34
6 cutaneous fibrous histiocytoma 29.6 SERPINA3 MME MLANA CD68 CD34
7 skin carcinoma 28.9 SOX10 PECAM1 MME MLANA KRT5 CD68
8 squamous cell carcinoma 10.7
9 keratosis 10.3
10 penis sarcoma 10.3 MLANA CD34
11 lung sarcoma 10.3 SERPINA3 CD34
12 hepatic angiomyolipoma 10.3 MLANA CD34
13 acanthoma 10.3 MLANA KRT5
14 adenosarcoma 10.3 SERPINA3 MME
15 gastric squamous cell carcinoma 10.3 SERPINA3 KRT5
16 breast secretory carcinoma 10.3 SERPINA3 KRT5
17 sensory organ benign neoplasm 10.3 MLANA KRT5
18 spermatic cord cancer 10.3 KRT5 CD34
19 large cell acanthoma 10.3 MLANA KRT5
20 liver fibroma 10.3 KRT5 CD34
21 melanoma 10.2
22 cervical serous adenocarcinoma 10.2 MME MLANA
23 juvenile xanthogranuloma 10.2 SERPINA3 MLANA
24 pediatric fibrosarcoma 10.2 SERPINA3 CD34
25 breast leiomyoma 10.2 MME CD34
26 mucinous stomach adenocarcinoma 10.2 MLANA KRT5
27 skin tag 10.2 SERPINA3 CD34
28 pacinian tumor 10.2 MME CD34
29 mucocele of appendix 10.2 MME CD34
30 apocrine adenocarcinoma 10.2 SERPINA3 KRT5
31 thymus clear cell carcinoma 10.2 MLANA KRT5
32 inflammatory liposarcoma 10.2 MME CD34
33 gastrointestinal lymphoma 10.2 SERPINA3 MME
34 congenital epulis 10.2 SERPINA3 CD68
35 epulis 10.2 SERPINA3 CD68
36 verruciform xanthoma of skin 10.2 SERPINA3 CD68
37 proliferative fasciitis 10.2 SERPINA3 CD68
38 malignant inflammatory fibrous histiocytoma 10.2 SERPINA3 CD68
39 reticulohistiocytic granuloma 10.2 SERPINA3 CD68
40 pancreas sarcoma 10.2 SERPINA3 CD68
41 xanthogranulomatous pyelonephritis 10.2 SERPINA3 CD68
42 sclerosing hepatic carcinoma 10.2 MME CD34
43 sarcomatoid transitional cell carcinoma 10.2 MLANA CD68
44 spinal cord melanoma 10.2 MLANA CD68
45 central nervous system leukemia 10.2 MME CD34
46 conjunctival nevus 10.2 SOX10 MLANA
47 cervix erosion 10.2 MME KRT5
48 multicentric reticulohistiocytosis 10.2 SERPINA3 CD68
49 ovarian sex-cord stromal tumor 10.2 MME MLANA
50 bartholin's gland adenocarcinoma 10.2 MLANA KRT5

Graphical network of the top 20 diseases related to Sarcomatoid Squamous Cell Skin Carcinoma:



Diseases related to Sarcomatoid Squamous Cell Skin Carcinoma

Symptoms & Phenotypes for Sarcomatoid Squamous Cell Skin Carcinoma

MGI Mouse Phenotypes related to Sarcomatoid Squamous Cell Skin Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.1 CD34 KRT5 MLANA MME SERPINA3 SOX10

Drugs & Therapeutics for Sarcomatoid Squamous Cell Skin Carcinoma

Search Clinical Trials , NIH Clinical Center for Sarcomatoid Squamous Cell Skin Carcinoma

Genetic Tests for Sarcomatoid Squamous Cell Skin Carcinoma

Anatomical Context for Sarcomatoid Squamous Cell Skin Carcinoma

MalaCards organs/tissues related to Sarcomatoid Squamous Cell Skin Carcinoma:

40
Skin, Tongue, Skeletal Muscle

Publications for Sarcomatoid Squamous Cell Skin Carcinoma

Articles related to Sarcomatoid Squamous Cell Skin Carcinoma:

(show top 50) (show all 62)
# Title Authors PMID Year
1
Cutaneous Spindle Cell Squamous Cell Carcinoma in Cats: Clinical, Histological, and Immunohistochemical Study. 61
33577428 2021
2
Primary Cutaneous Myxoid Spindle Cell Squamous Cell Carcinoma of the Scalp: A Case Report. 61
32701165 2021
3
Irradiated Skeletal Muscle Cells Mimicking Those of Atypical Fibroxanthoma on Mohs Frozen Sections. 61
32956095 2020
4
A genomic survey of sarcomas on sun-exposed skin reveals distinctive candidate drivers and potentially targetable mutations. 61
32540221 2020
5
A spindle cell squamous cell carcinoma on the cheek presenting with in-transit metastases and a satellite lesion. 61
32126623 2020
6
Unusual Presentation of Cutaneous Spindle Cell Squamous Cell Carcinoma: A Case Report. 61
32355488 2020
7
Laryngeal Basaloid Squamous Cell Carcinoma with a Substantial Spindle Cell Component: Case Presentation and Updated Review of Literature. 61
29869750 2019
8
Malignant Chondroid Syringoma: A Report of Two Cases with a Sarcomatous Mesenchymal Component. 61
31700847 2019
9
Clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare case. 61
30785474 2019
10
Prolonged Response to Pembrolizumab in Spindle Cell Squamous Cell Carcinoma Metastatic to the Central Nervous System. 61
31132886 2019
11
Pseudomyogenic Hemangioendothelioma. 61
31130564 2019
12
Carcinosarcomas of the esophagus: systematic review of a rare nosologic entity. 61
30570870 2018
13
A tale of two clones: Caldesmon staining in the differentiation of cutaneous spindle cell neoplasms. 61
29687929 2018
14
Summary of expression of SPARC protein in cutaneous vascular neoplasms and mimickers. 61
29660567 2018
15
Microphthalmia-associated transcription factor (MiTF): Promiscuous staining patterns in fibrohistiocytic lesions is a potential pitfall. 61
29773427 2018
16
Myoepithelial carcinoma of the tongue- spindle cell morphology with high mitosis: A case report and review of literature. 61
29323073 2017
17
Spindle cell squamous cell carcinoma arising in Bowen's disease: Case report and review of the published work. 61
28370387 2017
18
Sarcomatoid Squamous Cell Carcinoma of the Penis - a Report of Two Cases. 61
28704194 2017
19
FOSB is a Useful Diagnostic Marker for Pseudomyogenic Hemangioendothelioma. 61
28009608 2017
20
Squamous cell carcinoma of the upper aerodigestive tract: dysplasia and select variants. 61
28060368 2017
21
Case of spindle cell squamous cell carcinoma with dermoscopic findings of diffuse/discrete scales and predominant white color. 61
27075812 2016
22
Spindle cell squamous cell carcinoma arising from chronic osteomyelitis. 61
26590122 2016
23
Primary cutaneous myxoid spindle cell squamous cell carcinoma: a rare skin cancer. 61
26472290 2015
24
Spindle cell squamous cell carcinoma arising from verrucous hyperplasia during BRAF inhibitor therapy for melanoma. 61
25761417 2015
25
Cutaneous spindle cell squamous cell carcinoma. 61
25673951 2015
26
p40 is more specific than p63 for the distinction of atypical fibroxanthoma from other cutaneous spindle cell malignancies. 61
25029117 2014
27
An unusual presentation of an aggressive spindle cell skin cancer. 61
24971424 2014
28
The transcription factor Snail expressed in cutaneous squamous cell carcinoma induces epithelial-mesenchymal transition and down-regulates COX-2. 61
23261444 2013
29
Cutaneous basal cell carcinoma with dual differentiation into squamous cell carcinoma and spindle cell squamous cell carcinoma: a case report with immunohistochemical studies. 61
23227812 2013
30
Anti-cytokeratin CAM5.2 should not be mistaken for cytokeratin 8/18 monoclonal antibody: comment on "spindle cell squamous cell carcinoma not expressing stratified but simple epithelial cytokeratin: Efficacy of simple epithelial cytokeratin immunoreactivity" (Tokuriki A, Kiyohara T, Kouraba S, Kumakiri M, Journal of Dermatology 2012; 39: 72-75). 61
22963005 2012
31
Spindle cell neoplasms encountered in dermatologic surgery: a review. 61
22268379 2012
32
P75 nerve growth factor receptor as a useful marker to distinguish spindle cell melanoma from other spindle cell neoplasms of sun-damaged skin. 61
22207443 2012
33
Spindle cell squamous cell carcinoma not expressing stratified but simple epithelial cytokeratin: efficacy of simple epithelial cytokeratin immunoreactivity. 61
21954987 2012
34
The role of CD10 in distinguishing atypical fibroxanthoma from sarcomatoid (spindle cell) squamous cell carcinoma. 61
21883368 2011
35
Clinical and pathologic predictors of recurrence and survival in spindle cell squamous cell carcinoma. 61
21493284 2011
36
Laryngeal spindle cell squamous cell carcinoma. 61
21563088 2011
37
Cutaneous spindle cell squamous cell carcinoma in nevus sebaceous. 61
21091681 2010
38
Anti-cytokeratin CAM 5.2 does not act as a surrogate of the cytokeratin 8/18 monoclonal antibody. Comment on: "Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma", in J Cutan Pathol 2009; 36: 543. 61
20175827 2010
39
CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma. 61
20184665 2010
40
Desmoplastic/spindle cell squamous cell carcinoma of the skin. A diagnostically challenging tumor mimicking a scar: clinicopathologic and immunohistochemical study of 6 cases. 61
20514676 2010
41
Primary cutaneous myxoid spindle cell squamous cell carcinoma: a clinicopathologic study and review of the literature. 61
19811587 2010
42
Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma. 61
19476522 2009
43
Procollagen 1 and Melan-A expression in desmoplastic melanomas. 61
19318805 2009
44
Spindle cell squamous cell carcinoma showing epithelial-mesenchymal transition. 61
18482319 2009
45
Sarcomatoid squamous cell carcinoma: a long-standing case. 61
19104745 2008
46
Expression of OCT4 transcription factor in cutaneous neoplasia. 61
18091376 2007
47
Spindle cell neoplasm of skin: diagnostic dilemma. 61
18306566 2007
48
p63 is a useful marker for cutaneous spindle cell squamous cell carcinoma. 61
16776716 2006
49
Spindle cell squamous cell carcinoma showing continuous mesenchymal dedifferentiation in a single tumor. 61
16361733 2005
50
Metaplastic breast carcinoma histologically mimicking cutaneous spindle cell squamous cell carcinoma. 61
15900133 2005

Variations for Sarcomatoid Squamous Cell Skin Carcinoma

Expression for Sarcomatoid Squamous Cell Skin Carcinoma

Search GEO for disease gene expression data for Sarcomatoid Squamous Cell Skin Carcinoma.

Pathways for Sarcomatoid Squamous Cell Skin Carcinoma

Pathways related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.86 MME CD68 CD34

GO Terms for Sarcomatoid Squamous Cell Skin Carcinoma

Biological processes related to Sarcomatoid Squamous Cell Skin Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.26 SERPINA3 PECAM1 MME CD68
2 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Sources for Sarcomatoid Squamous Cell Skin Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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