Sarcomatoid Transitional Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Sarcomatoid Transitional Cell Carcinoma

MalaCards integrated aliases for Sarcomatoid Transitional Cell Carcinoma:

Name: Sarcomatoid Transitional Cell Carcinoma ¹² ¹⁵

Transitional Cell Carcinoma, Spindle Cell ⁷⁰

Transitional Cell Carcinoma, Sarcomatoid ¹²

Transitional Spindle Cell Carcinoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4014

NCIt ⁵⁰ C4120

SNOMED-CT ⁶⁷ 112676006

UMLS ⁷⁰ C0334271

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Summaries for Sarcomatoid Transitional Cell Carcinoma

Disease Ontology : ¹² A transitional cell carcinoma that has sarcoma-like components arising from the malignant transitional epithelium.

MalaCards based summary : Sarcomatoid Transitional Cell Carcinoma, also known as transitional cell carcinoma, spindle cell, is related to bladder sarcomatoid transitional cell carcinoma and kidney pelvis sarcomatoid transitional cell carcinoma. An important gene associated with Sarcomatoid Transitional Cell Carcinoma is CD68 (CD68 Molecule), and among its related pathways/superpathways is Glioma. Related phenotypes are integument and neoplasm

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Related Diseases for Sarcomatoid Transitional Cell Carcinoma

Diseases related to Sarcomatoid Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)

#	Related Disease	Score	Top Affiliating Genes
1	bladder sarcomatoid transitional cell carcinoma	11.7
2	kidney pelvis sarcomatoid transitional cell carcinoma	11.5
3	transitional cell carcinoma	10.4
4	heart lymphoma	10.2	CD68 ALK
5	malignant giant cell tumor of the tendon sheath	10.2	CD68 ALK
6	pseudosarcomatous fibromatosis	10.2	CD68 ALK
7	fibrous histiocytoma	10.2	CD68 ALK
8	maxillary sinus benign neoplasm	10.2	CDH1 ALK
9	pericardium disease	10.2	CD68 ALK
10	reticulosarcoma	10.2	CD68 ALK
11	myoblastoma	10.2	SYP CD68
12	lymphoepithelioma-like carcinoma	10.2	CDH1 ALK
13	pericardial effusion	10.1	CD68 ALK
14	pulmonary large cell neuroendocrine carcinoma	10.1	SYP ALK
15	large cell neuroendocrine carcinoma	10.1	SYP ALK
16	myxoid chondrosarcoma	10.1	SYP CD68
17	large cell medulloblastoma	10.1	SYP ALK
18	autonomic nervous system benign neoplasm	10.1	SYP ALK
19	peripheral nervous system benign neoplasm	10.1	SYP ALK
20	conjunctival pigmentation	10.1	MLANA CD68
21	sarcomatoid squamous cell skin carcinoma	10.1	MLANA CD68
22	breast neuroendocrine neoplasm	10.1	SYP CDH1
23	skin sarcoma	10.1	MLANA CD68
24	balloon cell malignant melanoma	10.1	MLANA CD68
25	malignant granular cell myoblastoma	10.1	MLANA CD68
26	pulmonary sclerosing hemangioma	10.1	SYP CDH1
27	fibrolamellar carcinoma	10.1	SYP CD68
28	bladder sarcoma	10.1	MLANA CD68
29	epithelioid sarcoma	10.1	SYP CD68
30	carcinosarcoma	10.1
31	rare tumor	10.1
32	ganglioneuroblastoma	10.1	SYP ALK
33	cutaneous fibrous histiocytoma	10.1	MLANA CD68
34	spitzoid melanoma	10.1	MLANA ALK
35	tubular adenocarcinoma	10.1	SYP CDH1
36	malignant leptomeningeal tumor	10.0	TYR MLANA
37	meningeal melanoma	10.0	TYR MLANA
38	ciliary body cancer	10.0	TYR MLANA
39	melanoacanthoma	10.0	TYR MLANA
40	halo nevi	10.0	TYR MLANA
41	melanomatosis	10.0	TYR MLANA
42	diffuse meningeal melanocytosis	10.0	TYR MLANA
43	glomangiosarcoma	10.0	SYP MLANA
44	sensory organ benign neoplasm	10.0	SYP MLANA
45	benign perivascular tumor	10.0	SYP MLANA
46	perivascular tumor	10.0	SYP MLANA
47	epithelioid cell melanoma	10.0	TYR MLANA
48	olfactory nerve neoplasm	10.0	SYP MLANA
49	cranial nerve malignant neoplasm	10.0	SYP MLANA
50	cranial nerve neoplasm	10.0	SYP MLANA

Graphical network of the top 20 diseases related to Sarcomatoid Transitional Cell Carcinoma:

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Symptoms & Phenotypes for Sarcomatoid Transitional Cell Carcinoma

MGI Mouse Phenotypes related to Sarcomatoid Transitional Cell Carcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	9.72	ALK CDH1 MLANA TP53 TYR
2	neoplasm	MP:0002006	9.56	ALK CDH1 TP53 TYR
3	no phenotypic analysis	MP:0003012	9.55	CD68 CDH1 MLANA TP53 TYR
4	normal	MP:0002873	9.35	ALK CDH1 SYP TP53 TYR
5	pigmentation	MP:0001186	8.92	ALK MLANA TP53 TYR

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Drugs & Therapeutics for Sarcomatoid Transitional Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Sarcomatoid Transitional Cell Carcinoma

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Genetic Tests for Sarcomatoid Transitional Cell Carcinoma

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Anatomical Context for Sarcomatoid Transitional Cell Carcinoma

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Publications for Sarcomatoid Transitional Cell Carcinoma

Articles related to Sarcomatoid Transitional Cell Carcinoma:

#	Title	Authors	PMID	Year
1	Pyonephrosis as a sign of sarcomatoid carcinoma of the renal pelvis. ⁶¹	Fernandez-Pello S...Menendez CL	24945010	2014
2	Sarcomatoid carcinoma of the renal pelvis with giant cell tumor-like features: case report with immunohistochemical findings. ⁶¹	Acikalin MF...Can C	15733116	2005
3	Fine needle aspiration biopsy of primary renal synovial sarcoma. A case report. ⁶¹	Vesoulis Z...Dankoff J	12920764	2003
4	Sarcomatoid transitional cell carcinoma of bladder managed with transurethral resection alone. ⁶¹	Nimeh T...Klein EA	11792937	2002
5	Sarcomatoid transitional cell carcinoma originating from a duplicated renal pelvis. ⁶¹	Hisataki T...Iwaki H	11851772	2001
6	Myxoid and sclerosing sarcomatoid transitional cell carcinoma of the urinary bladder: a clinicopathologic and immunohistochemical study of 25 cases. ⁶¹	Jones EC...Young RH	9310954	1997
7	Sarcomatoid transitional cell carcinoma of the renal pelvis. A report of five cases with clinical, pathological, immunohistochemical and DNA ploidy analysis. ⁶¹	Lopez-Beltran A...Vicioso-Recio L	9182292	1996

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Genes for Sarcomatoid Transitional Cell Carcinoma

Genes related to Sarcomatoid Transitional Cell Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CD68	CD68 Molecule	Protein Coding	4.98	DISEASES inferred ¹⁵
2	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	4.64	DISEASES inferred ¹⁵
3	CDH1	Cadherin 1	Protein Coding	4.23	DISEASES inferred ¹⁵
4	TYR	Tyrosinase	Protein Coding	4.03	DISEASES inferred ¹⁵
5	MLANA	Melan-A	Protein Coding	4	DISEASES inferred ¹⁵
6	TP53	Tumor Protein P53	Protein Coding	3.61	DISEASES inferred ¹⁵
7	SYP	Synaptophysin	Protein Coding	3.5	DISEASES inferred ¹⁵

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Variations for Sarcomatoid Transitional Cell Carcinoma

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Expression for Sarcomatoid Transitional Cell Carcinoma

Search GEO for disease gene expression data for Sarcomatoid Transitional Cell Carcinoma.

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Pathways for Sarcomatoid Transitional Cell Carcinoma

Pathways related to Sarcomatoid Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	11.4	TP53 CDH1 ALK

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GO Terms for Sarcomatoid Transitional Cell Carcinoma

Cellular components related to Sarcomatoid Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of membrane	GO:0016021	9.17	TYR TP53 SYP MLANA CDH1 CD68

Biological processes related to Sarcomatoid Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to UV	GO:0009411	8.62	TYR TP53

Molecular functions related to Sarcomatoid Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	copper ion binding	GO:0005507	9.16	TYR TP53
2	identical protein binding	GO:0042802	9.02	TYR TP53 SYP CDH1 ALK
3	protein self-association	GO:0043621	8.96	TP53 SYP

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Sources for Sarcomatoid Transitional Cell Carcinoma

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