MCID: SRC009
MIFTS: 33

Sarcomatosis

Categories: Cancer diseases

Aliases & Classifications for Sarcomatosis

MalaCards integrated aliases for Sarcomatosis:

Name: Sarcomatosis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7615
NCIt 50 C4243
SNOMED-CT 68 9395006
UMLS 73 C0334451

Summaries for Sarcomatosis

Disease Ontology : 12 A sarcoma that results in the formation of numerous sarcomas or located in various parts of the body.

MalaCards based summary : Sarcomatosis is related to sarcoma and liposarcoma. An important gene associated with Sarcomatosis is CREB3L1 (CAMP Responsive Element Binding Protein 3 Like 1), and among its related pathways/superpathways are Transcriptional misregulation in cancer and TGF-beta Signaling Pathways. The drugs Cisplatin and Melphalan have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and lung.

Related Diseases for Sarcomatosis

Graphical network of the top 20 diseases related to Sarcomatosis:



Diseases related to Sarcomatosis

Symptoms & Phenotypes for Sarcomatosis

Drugs & Therapeutics for Sarcomatosis

Drugs for Sarcomatosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved 15663-27-1 2767 441203 84093
2
Melphalan Approved 148-82-3 4053 460612
3
Oxaliplatin Approved, Investigational 61825-94-3 43805 6857599 5310940 9887054
4
Doxorubicin Approved, Investigational 23214-92-8 31703
5
Doxil Approved June 1999 31703
6 Mitomycins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 HIPEC For Peritoneal Surface Malignancies Including Carcinomatosis or Sarcomatosis ‐ Data Registry Recruiting NCT02082886
2 Prospective Follow-up of Outcomes in Patients Receiving Photodynamic Therapy for Neoplastic Diseases Recruiting NCT02159742
3 Radical Resection and HIPEC for Recurrent Retroperitoneal Sarcoma Recruiting NCT03792867 Not Applicable Doxorubicin

Search NIH Clinical Center for Sarcomatosis

Genetic Tests for Sarcomatosis

Anatomical Context for Sarcomatosis

MalaCards organs/tissues related to Sarcomatosis:

41
Spinal Cord, Brain, Lung, Liver, Spleen, Kidney, Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Sarcomatosis:

19
Various Parts Of The Body

Publications for Sarcomatosis

Articles related to Sarcomatosis:

(show top 50) (show all 85)
# Title Authors Year
1
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in seven patients with peritoneal sarcomatosis from uterine sarcoma. ( 29881584 )
2018
2
Peritoneal sarcomatosis 5 years after laparoscopic morcellation of uterine leiomyoma. ( 29338993 )
2018
3
Therapeutic management of peritoneal ascitic sarcomatosis by Ruta graveolens: A study in experimental mice. ( 30025594 )
2018
4
Multi-institutional study of peritoneal sarcomatosis from uterine sarcoma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. ( 28967566 )
2017
5
Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy for Management of Peritoneal Sarcomatosis: A Preliminary Single-Center Experience from Saudi Arabia. ( 27212941 )
2016
6
Long-Term Survival in a Patient With Abdominal Sarcomatosis From Uterine Leiomyosarcoma: Role of Repeated Laparoscopic Surgery in Treatment and Follow-Up. ( 27234428 )
2016
7
Locoregional treatment of peritoneal sarcomatosis A single-centre experience. ( 27680058 )
2016
8
Peritoneal sarcomatosis: site of origin for the establishment of an in vitro and in vivo cell line model to study therapeutic resistance in dedifferentiated liposarcoma. ( 26373732 )
2015
9
Intraperitoneal bleomycin for sarcomatosis-related malignant ascites: Prolonged symptom relief. ( 25833195 )
2015
10
Differences in CT features of peritoneal carcinomatosis, sarcomatosis, and lymphomatosis: Retrospective analysis of 122 cases at a tertiary cancer institution. ( 25308238 )
2014
11
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in sarcomatosis from gastrointestinal stromal tumor. ( 25197876 )
2014
12
Sclerosing epithelioid fibrosarcoma presenting as intraabdominal sarcomatosis with a novel EWSR1-CREB3L1 gene fusion. ( 25123073 )
2014
13
Aggressive locoregional management of recurrent peritoneal sarcomatosis. ( 23386388 )
2013
14
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with peritoneal sarcomatosis: long-term outcome from a single institution experience. ( 24023339 )
2013
15
A comparison between patients with gastrointestinal stromal tumours diagnosed with isolated liver metastases and liver metastases plus sarcomatosis. ( 23458233 )
2013
16
Peritoneal lymphomatosis: CT and PET/CT findings and how to differentiate between carcinomatosis and sarcomatosis. ( 23598428 )
2013
17
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in peritoneal sarcomatosis. ( 23711273 )
2013
18
Peritoneal sarcomatosis in pediatric malignancies. ( 23002005 )
2013
19
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for the treatment of peritoneal sarcomatosis. ( 22302269 )
2012
20
Peritoneal sarcomatosis associated with telemetry implants in Sprague Dawley CD rats: a review of eight cases. ( 22083584 )
2012
21
Toxicity of hyperthermic intraperitoneal chemotherapy (HIPEC) in pediatric patients with sarcomatosis/carcinomatosis: early experience and phase 1 results. ( 22492588 )
2012
22
Systematic review on the efficacy of multimodal treatment of sarcomatosis with cytoreduction and intraperitoneal chemotherapy. ( 20697824 )
2011
23
Peritoneal sarcomatosis versus peritoneal carcinomatosis: imaging findings at MDCT. ( 20729420 )
2010
24
Peritoneal sarcomatosis: is there a subset of patients who may benefit from cytoreductive surgery and hyperthermic intraperitoneal chemotherapy? ( 20585874 )
2010
25
Fatal abdominal sarcomatosis secondary to gastrointestinal stromal tumor with bland histology. ( 19882063 )
2009
26
Pulmonary lymphangitic sarcomatosis and a review of the literature. ( 18506585 )
2009
27
Subgroup J avian leukosis virus-induced histiocytic sarcomatosis occurs only in persistently viremic but not immunotolerized meat-type chickens. ( 19261641 )
2009
28
Gigantic fetal tonsillar sarcomatosis. ( 18504389 )
2008
29
The consensus statement on the locoregional treatment of abdominal sarcomatosis. ( 18726899 )
2008
30
Toxicity and outcomes associated with surgical cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with sarcomatosis. ( 17541691 )
2007
31
A phase II trial of intraperitoneal photodynamic therapy for patients with peritoneal carcinomatosis and sarcomatosis. ( 16638861 )
2006
32
Evaluation of intracavitary mitoxantrone and carboplatin for treatment of carcinomatosis, sarcomatosis and mesothelioma, with or without malignant effusions: A retrospective analysis of 12 cases (1997-2002)*. ( 19754772 )
2005
33
Randomized trial of cytoreduction followed by intraperitoneal chemotherapy versus cytoreduction alone in patients with peritoneal sarcomatosis. ( 15975759 )
2005
34
Primary leptomeningeal sarcomatosis; a pathology proven case with challenging MRI and clinical findings. ( 15015662 )
2004
35
Hypoxia and Photofrin uptake in the intraperitoneal carcinomatosis and sarcomatosis of photodynamic therapy patients. ( 15269134 )
2004
36
Patterns of recurrence in patients treated with photodynamic therapy for intraperitoneal carcinomatosis and sarcomatosis. ( 14767557 )
2004
37
Hyperthermic intraperitoneal intraoperative chemotherapy after cytoreductive surgery for the treatment of abdominal sarcomatosis: clinical outcome and prognostic factors in 60 consecutive patients. ( 15112276 )
2004
38
Secondary leptomeningeal sarcomatosis. ( 15504072 )
2004
39
Quantitative prognostic indicators of peritoneal surface malignancy: carcinomatosis, sarcomatosis, and peritoneal mesothelioma. ( 14567023 )
2003
40
Tumor volume as a prognostic factor for sarcomatosis. ( 12015769 )
2002
41
Cytoreduction and intraperitoneal chemotherapy for the management of peritoneal carcinomatosis, sarcomatosis and mesothelioma. ( 11869020 )
2002
42
Abdominal and pelvic CT for detection and volume assessment of peritoneal sarcomatosis. ( 12195759 )
2002
43
Hyperthermic intraoperative intraperitoneal chemotherapy with cisplatin and doxorubicin in patients who undergo cytoreductive surgery for peritoneal carcinomatosis and sarcomatosis: phase I study. ( 11900234 )
2002
44
Preliminary report of photodynamic therapy for intraperitoneal sarcomatosis. ( 11314943 )
2001
45
Multimodal treatment of peritoneal carcinomatosis and sarcomatosis. ( 11289746 )
2001
46
Review of a personal experience in the management of carcinomatosis and sarcomatosis. ( 11902487 )
2001
47
Hyperthermic intraoperative intraperitoneal chemotherapy for peritoneal carcinomatosis and sarcomatosis using a cardioplegia heat exchanger and a two-pump system: a case report. ( 11131220 )
2000
48
Pulmonary lymphangitic sarcomatosis from cutaneous angiosarcoma: an unusual presentation of diffuse interstitial lung disease. ( 10770568 )
2000
49
Melanotic peritoneal sarcomatosis originating from clear cell sarcoma. ( 10504528 )
1999
50
Clear cell sarcoma of the abdominal wall with peritoneal sarcomatosis: CT features. ( 10525863 )
1999

Variations for Sarcomatosis

Expression for Sarcomatosis

Search GEO for disease gene expression data for Sarcomatosis.

Pathways for Sarcomatosis

Pathways related to Sarcomatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.19 ATF1 EWSR1 HMGA2 WT1
2 11.14 ATF1 CREB3L1
3 10.75 ATF1 CREB3L1

GO Terms for Sarcomatosis

Cellular components related to Sarcomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.1 ATF1 CREB3L1 EWSR1 FMN1 HMGA2 WT1

Biological processes related to Sarcomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.5 CREB3L1 HMGA2 WT1
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.46 ATF1 CREB3L1 HMGA2 WT1
3 negative regulation of transcription, DNA-templated GO:0045892 9.43 CREB3L1 HMGA2 WT1
4 transcription by RNA polymerase II GO:0006366 9.26 ATF1 CREB3L1 HMGA2 WT1
5 regulation of transcription, DNA-templated GO:0006355 9.02 ATF1 CREB3L1 EWSR1 HMGA2 WT1

Molecular functions related to Sarcomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.67 ATF1 CREB3L1 HMGA2 WT1
2 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 9.43 CREB3L1 HMGA2 WT1
3 transcription regulatory region DNA binding GO:0044212 9.33 CREB3L1 HMGA2 WT1
4 SMAD binding GO:0046332 9.32 CREB3L1 HMGA2
5 C2H2 zinc finger domain binding GO:0070742 8.96 HMGA2 WT1
6 cAMP response element binding GO:0035497 8.62 CREB3L1 HMGA2

Sources for Sarcomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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