MCID: SRC009
MIFTS: 31

Sarcomatosis

Categories: Cancer diseases

Aliases & Classifications for Sarcomatosis

MalaCards integrated aliases for Sarcomatosis:

Name: Sarcomatosis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:7615
NCIt 50 C4243
SNOMED-CT 67 9395006
UMLS 70 C0334451

Summaries for Sarcomatosis

Disease Ontology : 12 A sarcoma that results in the formation of numerous sarcomas or located in various parts of the body.

MalaCards based summary : Sarcomatosis is related to desmoplastic small round cell tumor and sarcoma. An important gene associated with Sarcomatosis is EWSR1 (EWS RNA Binding Protein 1), and among its related pathways/superpathways are P38 MAPK Signaling Pathway (sino) and Transcriptional misregulation in cancer. The drugs Melphalan and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include various parts of the body, spinal cord and skin.

Related Diseases for Sarcomatosis

Diseases related to Sarcomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 desmoplastic small round cell tumor 30.0 WT1 EWSR1
2 sarcoma 29.9 WT1 EWSR1 ATF1
3 clear cell sarcoma 29.6 WT1 EWSR1 ATF1
4 fibrous histiocytoma 29.6 EWSR1 ATF1
5 ewing sarcoma 29.3 WT1 EWSR1 ATF1
6 sarcomatosis of the meninges 11.4
7 gastrointestinal stromal tumor 10.3
8 leiomyosarcoma 10.3
9 angiosarcoma 10.2
10 cauda equina neoplasm 10.1 WT1 EWSR1
11 small intestinal sarcoma 10.1 WT1 EWSR1
12 cerebellar angioblastoma 10.1 WT1 EWSR1
13 middle ear carcinoma 10.1 WT1 EWSR1
14 benign mesothelioma 10.1
15 liposarcoma 10.1
16 spindle cell sarcoma 10.1
17 soft tissue sarcoma 10.1
18 epithelioid cell synovial sarcoma 10.1 WT1 EWSR1
19 synovium cancer 10.1 WT1 EWSR1
20 small cell osteogenic sarcoma 10.1 EWSR1 CREB3L1
21 kidney fibrosarcoma 10.1 EWSR1 CREB3L1
22 skeletal muscle cancer 10.1 WT1 EWSR1
23 conventional central osteosarcoma 10.1 EWSR1 CREB3L1
24 melanoma of soft tissue 10.0 EWSR1 ATF1
25 fibrosarcoma 10.0
26 rhabdoid cancer 10.0 WT1 EWSR1
27 bullous skin disease 10.0 PPL EPPK1
28 myxofibrosarcoma 10.0 EWSR1 CREB3L1
29 medulloblastoma 9.9
30 osteogenic sarcoma 9.9
31 meningioma, familial 9.9
32 dedifferentiated liposarcoma 9.9
33 intracranial meningioma 9.9
34 adult respiratory distress syndrome 9.9
35 peritoneal mesothelioma 9.9
36 secretory meningioma 9.9
37 lymphoplasmacyte-rich meningioma 9.9
38 tuberculous meningitis 9.9
39 uterine sarcoma 9.9
40 rare tumor 9.9
41 rhabdomyosarcoma 2 9.9 WT1 EWSR1
42 bone osteosarcoma 9.9 EWSR1 CREB3L1
43 chondrosarcoma, extraskeletal myxoid 9.8 WT1 EWSR1 ATF1
44 aortic aneurysm, familial abdominal, 1 9.8
45 amyotrophic lateral sclerosis 1 9.8
46 leiomyoma, uterine 9.8
47 lymphoma, hodgkin, classic 9.8
48 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.8
49 mycosis fungoides 9.8
50 reticulum cell sarcoma 9.8

Graphical network of the top 20 diseases related to Sarcomatosis:



Diseases related to Sarcomatosis

Symptoms & Phenotypes for Sarcomatosis

Drugs & Therapeutics for Sarcomatosis

Drugs for Sarcomatosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melphalan Approved 148-82-3 4053 460612
2
Cisplatin Approved 15663-27-1 84093 441203 2767
3
Oxaliplatin Approved, Investigational 61825-94-3 5310940 9887054 43805 6857599
4
Doxorubicin Approved, Investigational 23214-92-8 31703
5 Mitomycins
6
Liposomal doxorubicin 31703

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) For Peritoneal Surface Malignancies Including Carcinomatosis or Sarcomatosis - Data Registry Completed NCT02082886

Search NIH Clinical Center for Sarcomatosis

Genetic Tests for Sarcomatosis

Anatomical Context for Sarcomatosis

The Foundational Model of Anatomy Ontology organs/tissues related to Sarcomatosis:

19
Various Parts Of The Body

MalaCards organs/tissues related to Sarcomatosis:

40
Spinal Cord, Skin, Bone Marrow, Bone, Small Intestine, Liver, Eye

Publications for Sarcomatosis

Articles related to Sarcomatosis:

(show top 50) (show all 307)
# Title Authors PMID Year
1
GATA-3 expression in a de-differentiated chondrosarcoma with cutaneous iatrogenic implantation: a diagnostic pitfall with important clinical implications. 61
33655510 2021
2
18F-FDG PET/CT for Monitoring of Disease Progression in Metastatic Perivascular Epithelioid Cell Tumor. 61
33315683 2021
3
Clinical, CT, and ultrasonographic features of canine and feline pleural and peritoneal carcinomatosis and sarcomatosis. 61
33476083 2021
4
Peritoneal lymphomatosis. A case report. 61
33485812 2020
5
Bleeding "sarcomatosis" as a rare presentation of vascular graft-related angiosarcoma: case report and review of the literature. 61
33218319 2020
6
Angiosarcomas of Primary Gynecologic Origin - A Case Series and Review of the Literature. 61
32988901 2020
7
Unusual presentation of small bowel GIST: diffuse omental & mesenteric sarcomatosis. 61
32994921 2020
8
Peritoneal sarcomatosis: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. 61
32886567 2020
9
Hyperthermic intraperitoneal chemotherapy (HIPEC) for gynecological cancer. 61
32715605 2020
10
Fibrosarcoma with sarcomatosis and metastasis in a FeLV-negative cat. 61
32232857 2020
11
Clinical features and surgical outcomes of major urological interventions during cytoreductive surgery and hyperthermic intraperitoneal chemotheraphy. 61
33354230 2020
12
Otopathology in Angiosarcoma of the Temporal Bone. 61
30536838 2019
13
Cytoreductive Surgery in Combination with HIPEC in the Treatment of Peritoneal Sarcomatosis. 61
30948870 2019
14
Dedifferentiated liposarcoma with a rare presentation of disseminated intraperitoneal sarcomatosis: A case report. 61
31280066 2019
15
Long-term survival is possible using cytoreductive surgery plus HIPEC for sarcomatosis-Case report of 2 patients. 61
31590134 2019
16
A Simplified Peritoneal Sarcomatosis Score for patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. 61
30603133 2018
17
Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient Survival. 61
29871905 2018
18
Surgery for Gastrointestinal Stromal Tumors: State of the Art of Laparoscopic Resection and Surgery for M1 Tumors. 61
30498704 2018
19
Therapeutic management of peritoneal ascitic sarcomatosis by Ruta graveolens: A study in experimental mice. 61
30025594 2018
20
Primary Myxoid Liposarcoma of the Greater Omentum in a Rhesus Macaque (Macaca mulatta). 61
30071917 2018
21
Brain Metastases from Adult Sarcoma: Prognostic Factors and Impact of Treatment. A Retrospective Analysis from the French Sarcoma Group (GSF/GETO). 61
29934413 2018
22
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in seven patients with peritoneal sarcomatosis from uterine sarcoma. 61
29881584 2018
23
Peritoneal sarcomatosis 5 years after laparoscopic morcellation of uterine leiomyoma. 61
29338993 2018
24
Multi-institutional study of peritoneal sarcomatosis from uterine sarcoma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. 61
28967566 2017
25
Abdominal leiomyosarcomatosis after surgery with external morcellation for occult smooth muscle tumors of uncertain malignant potential: A case report. 61
28755615 2017
26
[A rare case of rapidly progressing primary diffuse meningeal sarcomatosis of the brain and spinal cord]. 61
28745675 2017
27
Autophagy Induction Results in Enhanced Anoikis Resistance in Models of Peritoneal Disease. 61
27807188 2017
28
Long-Term Survival in a Patient With Abdominal Sarcomatosis From Uterine Leiomyosarcoma: Role of Repeated Laparoscopic Surgery in Treatment and Follow-Up. 61
27234428 2016
29
Cytoreductive Surgery and HIPEC as a Treatment Option for Laparoscopic Resection of Uterine Leiomyosarcoma with Morcellation: Early Results. 61
26545375 2016
30
Peritoneal sarcomatosis: site of origin for the establishment of an in vitro and in vivo cell line model to study therapeutic resistance in dedifferentiated liposarcoma. 61
26373732 2016
31
A Case of a Gastrointestinal Stromal Tumor Diagnosed at the Postpartum Period. 61
27957364 2016
32
Locoregional treatment of peritoneal sarcomatosis A single-centre experience. 61
27680058 2016
33
Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy for Management of Peritoneal Sarcomatosis: A Preliminary Single-Center Experience from Saudi Arabia. 61
27212941 2016
34
Intraperitoneal bleomycin for sarcomatosis-related malignant ascites: Prolonged symptom relief. 61
25833195 2015
35
Debulking surgery and hyperthermic intraperitoneal chemotherapy in the management of a recurrent aggressive uterine myxoid leiomyosarcoma with peritoneal dissemination. 61
26425725 2015
36
Hypercalcemia and parathyroid hormone-related peptide expression in a dog with thyroid carcinoma and histiocytic sarcoma. 61
25707928 2015
37
Cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for children, adolescents, and young adults: the first 50 cases. 61
25564159 2015
38
The role of hyperthermic intraperitoneal chemotherapy (HIPEC) and isolated perfusion (ILP) interventions in sarcoma. 61
25351775 2015
39
Multimodality imaging of common and uncommon peritoneal diseases: a review for radiologists. 61
25139643 2015
40
[Cytoreductive surgery and HIPEC for peritoneal malignancies in children]. 61
25531634 2014
41
Differences in CT features of peritoneal carcinomatosis, sarcomatosis, and lymphomatosis: retrospective analysis of 122 cases at a tertiary cancer institution. 61
25308238 2014
42
Sclerosing epithelioid fibrosarcoma presenting as intraabdominal sarcomatosis with a novel EWSR1-CREB3L1 gene fusion. 61
25123073 2014
43
Intraperitoneal chemotherapy: rationale, applications, and limitations. 61
24166789 2014
44
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in sarcomatosis from gastrointestinal stromal tumor. 61
25197876 2014
45
Neutrophil-to-lymphocyte ratio: could it be used in the clinic as prognostic marker for gastrointestinal stromal tumor? 61
25436357 2014
46
Laparoscopic resection for 125 gastroduodenal submucosal tumors. 61
24783179 2014
47
Retroperitoneal sarcomas: patterns of care in advanced stages, prognostic factors and focus on main histological subtypes: a multicenter analysis of the French Sarcoma Group. 61
24496921 2014
48
Retroperitoneal sarcomas: patterns of care at diagnosis, prognostic factors and focus on main histological subtypes: a multicenter analysis of the French Sarcoma Group. 61
24567518 2014
49
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of recurrent high-grade uterine sarcoma with peritoneal dissemination. 61
24211479 2014
50
The value of re-exploration in patients with inadvertently morcellated uterine sarcoma. 61
24296345 2014

Variations for Sarcomatosis

Expression for Sarcomatosis

Search GEO for disease gene expression data for Sarcomatosis.

Pathways for Sarcomatosis

Pathways related to Sarcomatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.16 CREB3L1 ATF1
2 11.08 WT1 EWSR1 ATF1
3 10.94 CREB3L1 ATF1

GO Terms for Sarcomatosis

Cellular components related to Sarcomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.96 PPL EVPLL
2 intermediate filament GO:0005882 8.92 PPL MACF1 EVPLL EPPK1

Biological processes related to Sarcomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 wound healing GO:0042060 9.26 PPL MACF1 EVPLL EPPK1
2 intermediate filament cytoskeleton organization GO:0045104 8.92 PPL MACF1 EVPLL EPPK1

Molecular functions related to Sarcomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA binding GO:0003723 9.55 WT1 NOA1 MACF1 EWSR1 EPPK1
2 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.43 WT1 CREB3L1 ATF1
3 intermediate filament binding GO:0019215 8.96 EVPLL EPPK1
4 structural molecule activity GO:0005198 8.92 PPL MACF1 EVPLL EPPK1

Sources for Sarcomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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