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MCID: SRC004
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Sarcomatous Intrahepatic Cholangiocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases
Genes Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Sarcomatous Intrahepatic Cholangiocarcinoma

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MalaCards integrated aliases for Sarcomatous Intrahepatic Cholangiocarcinoma:

Name: Sarcomatous Intrahepatic Cholangiocarcinoma 12 15
Sarcomatoid Intrahepatic Cholangiocarcinoma 70

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:8072
NCIt 50 C41620
UMLS 70 C1519184
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Summaries for Sarcomatous Intrahepatic Cholangiocarcinoma

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MalaCards based summary : Sarcomatous Intrahepatic Cholangiocarcinoma, also known as sarcomatoid intrahepatic cholangiocarcinoma, is related to intrahepatic cholangiocarcinoma and embryonal sarcoma, and has symptoms including abdominal pain and malaise. An important gene associated with Sarcomatous Intrahepatic Cholangiocarcinoma is ANO1 (Anoctamin 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Sarcomatous Intrahepatic Cholangiocarcinoma

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Diseases related to Sarcomatous Intrahepatic Cholangiocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 420)
# Related Disease Score Top Affiliating Genes
1 intrahepatic cholangiocarcinoma 30.7 KRT7 KRT19 GPC3 AFP
2 embryonal sarcoma 30.5 KIT GPC3
3 cholecystolithiasis 30.2 GPT CEACAM5
4 gastrointestinal stromal tumor 29.8 PDGFRB KIT CD34 ANO1
5 cholangiocarcinoma 29.7 KRT8 KRT7 KRT19 GPC3 CEACAM5 AFP
6 ovarian embryonal carcinoma 10.4 GPC3 AFP
7 testicular malignant germ cell cancer 10.3 GPC3 AFP
8 bile duct adenoma 10.3 KRT7 KRT19
9 cervical mucinous adenocarcinoma 10.3 KRT7 CALD1
10 rete testis neoplasm 10.3 KRT7 AFP
11 rete testis adenocarcinoma 10.3 KRT7 AFP
12 rectum neuroendocrine neoplasm 10.3 KRT7 AFP
13 epididymal neoplasm 10.3 KRT7 AFP
14 uterus perivascular epithelioid cell tumor 10.3 KRT7 CALD1
15 adenofibroma 10.3 KRT7 KRT19
16 liver lipoma 10.3 CEACAM5 AFP
17 middle ear adenocarcinoma 10.3 KRT7 AFP
18 gestational ovarian choriocarcinoma 10.3 CEACAM5 AFP
19 immature teratoma of ovary 10.3 CEACAM5 AFP
20 urachal adenocarcinoma 10.3 CEACAM5 AFP
21 rectum signet ring adenocarcinoma 10.3 CEACAM5 AFP
22 adult teratoma 10.3 CEACAM5 AFP
23 endobronchial lipoma 10.3 KRT7 CALD1
24 urethra leiomyoma 10.3 KIT CALD1
25 pancreatic acinar cell adenocarcinoma 10.3 KRT19 AFP
26 dermoid cyst of ovary 10.3 CEACAM5 AFP
27 mediastinum seminoma 10.3 KIT AFP
28 mixed germ cell tumor 10.3 KIT AFP
29 lipoadenoma 10.3 KRT7 KRT19
30 middle ear carcinoma 10.3 KRT7 AFP
31 prostate embryonal rhabdomyosarcoma 10.3 KIT CALD1
32 extragonadal seminoma 10.3 KIT AFP
33 cervical adenoma malignum 10.3 KRT7 CALD1
34 gastric leiomyosarcoma 10.3 KIT ANO1
35 pineal region teratoma 10.3 KIT AFP
36 small intestinal sarcoma 10.3 KIT ANO1
37 leukoplakia of penis 10.3 KRT7 CEACAM5
38 glomangioma 10.3 CD34 CALD1
39 gastric hemangioma 10.3 KIT ANO1
40 urethral villous adenoma 10.3 KRT7 CEACAM5
41 mucinous adenofibroma 10.3 KRT7 CEACAM5
42 epididymis adenocarcinoma 10.3 KRT7 AFP
43 epididymis cancer 10.3 KRT7 AFP
44 pancreatic foamy gland adenocarcinoma 10.3 KRT7 CEACAM5
45 malignant acrospiroma 10.3 KRT7 CEACAM5
46 intravascular angioleiomyoma 10.3 CD34 CALD1
47 anal paget's disease 10.3 KRT7 CEACAM5
48 pancreatic serous cystadenocarcinoma 10.3 KRT7 CEACAM5
49 parasagittal meningioma 10.3 CD34 ANO1
50 urinary bladder villous adenoma 10.3 KRT7 CEACAM5

Graphical network of the top 20 diseases related to Sarcomatous Intrahepatic Cholangiocarcinoma:



Diseases related to Sarcomatous Intrahepatic Cholangiocarcinoma
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Symptoms & Phenotypes for Sarcomatous Intrahepatic Cholangiocarcinoma

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UMLS symptoms related to Sarcomatous Intrahepatic Cholangiocarcinoma:


abdominal pain; malaise

GenomeRNAi Phenotypes related to Sarcomatous Intrahepatic Cholangiocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 9.28 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.28 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.28 AFP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.28 KRT8
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.28 AFP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.28 AFP
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.28 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.28 AFP

MGI Mouse Phenotypes related to Sarcomatous Intrahepatic Cholangiocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 ANO1 GPC3 KIT KRT19 KRT8 NKX2-1
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Drugs & Therapeutics for Sarcomatous Intrahepatic Cholangiocarcinoma

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Search Clinical Trials , NIH Clinical Center for Sarcomatous Intrahepatic Cholangiocarcinoma

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Genetic Tests for Sarcomatous Intrahepatic Cholangiocarcinoma

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Anatomical Context for Sarcomatous Intrahepatic Cholangiocarcinoma

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Publications for Sarcomatous Intrahepatic Cholangiocarcinoma

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Articles related to Sarcomatous Intrahepatic Cholangiocarcinoma:

# Title Authors PMID Year
1
Sarcomatoid intrahepatic cholangiocarcinoma in a patient with poor prognosis: a case report and literature review. 61
33161814 2020
2
Sarcomatoid intrahepatic cholangiocarcinoma mimicking liver abscess: A case report. 61
31970189 2020
3
Sarcomatous carcinoma in biliary system: A retrospective study. 61
30813178 2019
4
Successful Resection of Solitary Abdominal Wall Metastasis of Sarcomatous Intrahepatic Cholangiocarcinoma. 61
31182943 2019
5
Sarcomatous intrahepatic cholangiocarcinoma: Case report and literature review: Erratum. 61
30335031 2018
6
Imaging and clinical features of primary hepatic sarcomatous carcinoma. 61
30314525 2018
7
Sarcomatous intrahepatic cholangiocarcinoma: Case report and literature review. 61
30278551 2018
8
Intrahepatic Sarcomatous Cholangiocarcinoma: Case Report and Review of the Literature. 61
29619266 2018
9
Imaging features of hepatic sarcomatous carcinoma on computed tomography and gadoxetic acid-enhanced magnetic resonance imaging. 61
28078380 2017
10
Prognosis analysis of sarcomatous intrahepatic cholangiocarcinoma from a review of the literature. 61
23824556 2014
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Variations for Sarcomatous Intrahepatic Cholangiocarcinoma

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Expression for Sarcomatous Intrahepatic Cholangiocarcinoma

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Search GEO for disease gene expression data for Sarcomatous Intrahepatic Cholangiocarcinoma.
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Pathways for Sarcomatous Intrahepatic Cholangiocarcinoma

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Pathways related to Sarcomatous Intrahepatic Cholangiocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytoskeletal Signaling 4
11.75 KRT8 KRT7 KRT19 CALD1
2
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.62 PDGFRB KRT19 AFP
3
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.5 KIT CEACAM5 CD34
4
Keratinization 65
Show member pathways
 11.38 KRT9 KRT8 KRT7 KRT19
5
Cytoskeleton remodeling Neurofilaments 23
Show member pathways
 11.37 KRT8 KRT7 KRT19
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GO Terms for Sarcomatous Intrahepatic Cholangiocarcinoma

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Cellular components related to Sarcomatous Intrahepatic Cholangiocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.95 KRT9 KRT8 KRT7 KRT19 GPT CEACAM5
2 apical plasma membrane GO:0016324 9.56 PDGFRB CEACAM5 CD34 ANO1
3 cell surface GO:0009986 9.55 PDGFRB KIT GPC3 CEACAM5 CD34
4 apicolateral plasma membrane GO:0016327 9.43 KRT8 KRT19
5 costamere GO:0043034 9.37 KRT8 KRT19
6 dystrophin-associated glycoprotein complex GO:0016010 9.32 KRT8 KRT19
7 cell periphery GO:0071944 9.13 KRT8 KRT19 CD34
8 intermediate filament GO:0005882 8.92 KRT9 KRT8 KRT7 KRT19

Biological processes related to Sarcomatous Intrahepatic Cholangiocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of phospholipase C activity GO:0010863 9.26 PDGFRB KIT
2 keratinization GO:0031424 9.26 KRT9 KRT8 KRT7 KRT19
3 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT8 KRT19
4 cornification GO:0070268 8.92 KRT9 KRT8 KRT7 KRT19
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Sources for Sarcomatous Intrahepatic Cholangiocarcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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