MCID: SCB001
MIFTS: 50

Scabies

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Scabies

MalaCards integrated aliases for Scabies:

Name: Scabies 12 74 42 3 15 71 32
Infestation by Sarcoptes Scabiei Var Hominis 12
Infestation by Sarcoptes Scabiei 12
Sarcoptic Itch 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8295
ICD9CM 34 133.0
NCIt 49 C34998
SNOMED-CT 67 128869009
ICD10 32 B86
UMLS 71 C0036262

Summaries for Scabies

MedlinePlus : 42 Scabies is an itchy skin condition caused by the microscopic mite Sarcoptes scabei. It is common all over the world, and can affect anyone. Scabies spreads quickly in crowded conditions where there is frequent skin-to-skin contact between people. Hospitals, child-care centers, and nursing homes are examples. Scabies can easily infect sex partners and other household members. Sharing clothes, towels, and bedding can sometimes spread scabies. This can happen much more easily when the infested person has crusted scabies. You cannot get scabies from a pet. Pets get a different mite infection called mange. Symptoms are Pimple-like irritations or a rash Intense itching, especially at night Sores caused by scratching Your health care provider diagnoses scabies by looking at the skin rash and finding burrows in the skin. Several lotions are available to treat scabies. The infected person's clothes, bedding and towels should be washed in hot water and dried in a hot dryer. Treatment is also recommended for household members and sexual partners. Centers for Disease Control and Prevention

MalaCards based summary : Scabies, also known as infestation by sarcoptes scabiei var hominis, is related to norwegian scabies and pyoderma, and has symptoms including fever, pruritus and exanthema. An important gene associated with Scabies is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Azithromycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

CDC : 3 Scabies is an infestation of the skin by the human itch mite (Sarcoptes scabiei var. hominis). The microscopic scabies mite burrows into the upper layer of the skin where it lives and lays its eggs. The most common symptoms of scabies are intense itching and a pimple-like skin rash. The scabies mite usually is spread by direct, prolonged, skin-to-skin contact with a person who has scabies. Scabies is found worldwide and affects people of all races and social classes. Scabies can spread rapidly under crowded conditions where close body and skin contact is frequent. Institutions such as nursing homes, extended-care facilities, and prisons are often sites of scabies outbreaks. Child-care facilities also are a common site of scabies infestations.

Wikipedia : 74 Scabies, also known as the seven-year itch, is a contagious skin infestation by the mite Sarcoptes... more...

Related Diseases for Scabies

Diseases related to Scabies via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 478)
# Related Disease Score Top Affiliating Genes
1 norwegian scabies 34.5 CD4 AADACL3
2 pyoderma 31.0 CXCL8 CSF3 CCR6
3 rheumatic fever 31.0 MBL2 IL1A IL10
4 bullous pemphigoid 30.8 IL31 CXCL8 CCL11
5 exanthem 30.6 IL10 CXCL8 CSF3 CD4 CCR6
6 acquired immunodeficiency syndrome 30.5 IL10 GSTM1 CD4 CCR6
7 dermatophytosis 30.4 FLNA CD4 CCR6
8 endocarditis 30.2 IL1A IL10 CXCL8
9 cellulitis 30.2 IL10 CD4 CCR6
10 human immunodeficiency virus type 1 30.1 IL10 CFP CD4 CCL11
11 dermatitis herpetiformis 30.1 IL31 IL10 CXCL8 CCL11
12 chickenpox 30.1 IL10 CD4 CCR6
13 adult t-cell leukemia 30.1 TNFRSF8 CD4 CCR6
14 lichen planus 30.0 IL10 FLG CXCL8
15 rosacea 30.0 GSTM1 CXCL8 CCR6
16 autoimmune disease 30.0 MBL2 IL1A IL10 CXCL8 CCR6
17 candidiasis 30.0 MBL2 IL10 CXCL8 CCR6
18 osteomyelitis 30.0 IL1A IL10 CXCL8 CSF3
19 chronic graft versus host disease 30.0 IL1A IL10 CD4
20 bacterial vaginosis 29.9 MBL2 IL1A IL10 CXCL8
21 leprosy 3 29.9 IL10 FLNA CXCL8 CD4 CCR6
22 hyper ige syndrome 29.9 IL10 CXCL8 CCR6 CCL11
23 leishmaniasis 29.9 MBL2 IL1A IL10 CXCL8
24 neutropenia 29.8 MBL2 KITLG IL10 CXCL8 CSF3
25 diarrhea 29.8 IL10 FLNA CXCL8 CSF3
26 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 29.8 IL10 CD4 CCR6
27 genital herpes 29.8 IL10 CD4 CCR6
28 folliculitis 29.7 CD4 CCR6 CCL11
29 herpes zoster 29.7 IL10 CD4 CCR6
30 pneumocystosis 29.7 CSF3 CD4 CCR6
31 allergic hypersensitivity disease 29.6 KITLG IL10 CXCL8 CD4 CCR6 CCL11
32 immunoglobulin alpha deficiency 29.6 MBL2 CD4 CCR6
33 chronic mucocutaneous candidiasis 29.6 IL10 CD4 CCR6
34 lymphadenitis 29.6 IL10 CXCL8 CD4 CCR6
35 parasitic helminthiasis infectious disease 29.5 IL10 CD4 CCR6 CCL11
36 mastocytosis 29.5 TNFRSF8 KITLG IL31
37 t-cell adult acute lymphocytic leukemia 29.4 TNFRSF8 CD4 CCR6
38 pneumonia 29.3 MBL2 IL1A IL10 CXCL8 CSF3 CCL11
39 seborrheic dermatitis 29.3 IL1A FLG CD4 CCR6
40 bacterial infectious disease 29.3 MBL2 IL1A IL10 CXCL8 CSF3 CFP
41 irritant dermatitis 29.3 IL31 IL1A FLG CXCL8
42 myelodysplastic syndrome 29.3 KITLG IL1A IL10 GSTM1 CXCL8 CSF3
43 respiratory failure 29.3 IL10 CXCL8 CD4 CCR6 CCL11
44 immune deficiency disease 29.3 TNFRSF8 MBL2 IL1A IL10 CFP CD4
45 epidermolysis bullosa pruriginosa 29.2 IL31 FLG
46 dermatitis 29.2 IL31 IL1A IL10 FLG CXCL8 CCR6
47 systemic lupus erythematosus 29.2 MBL2 IL1A IL10 CXCL8 CSF3 CD4
48 leukemia, acute lymphoblastic 29.2 KITLG GSTM1 CSF3 CD4 CCR6
49 lung disease 29.1 MBL2 IL1A IL10 FLNA CXCL8 CSF3
50 pulmonary disease, chronic obstructive 29.0 IL10 GSTM1 CXCL8 CD4 CCR6 CCL11

Comorbidity relations with Scabies via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Heart Disease Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Scabies:



Diseases related to Scabies

Symptoms & Phenotypes for Scabies

UMLS symptoms related to Scabies:


fever, pruritus, exanthema

MGI Mouse Phenotypes related to Scabies:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 CCL11 CCR6 CD4 CSF3 FLNA IL10
2 immune system MP:0005387 9.36 CCL11 CCR6 CD4 CFP CSF3 FLNA

Drugs & Therapeutics for Scabies

Drugs for Scabies (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 447043 55185
2 Anti-Bacterial Agents Phase 4
3
Permethrin Approved, Investigational Phase 3 52645-53-1 40326
4
Malathion Approved, Investigational Phase 3 121-75-5 4004
5
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 3 90-89-1 3052
6
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
7
Metronidazole Approved Phase 3 443-48-1 4173
8 Emollients Phase 3
9 Anthelmintics Phase 3
10 Cholinergic Agents Phase 3
11 Cholinesterase Inhibitors Phase 3
12 Neurotransmitter Agents Phase 3
13 Tubulin Modulators Phase 3
14 Antiprotozoal Agents Phase 3
15 Antimitotic Agents Phase 3
16
Ivermectin Approved, Investigational, Vet_approved Phase 2 70288-86-7 6474909
17
Fennel Approved, Experimental Phase 2
18 Milbemycin Phase 2
19 Antiparasitic Agents Phase 2
20 Anti-Infective Agents Phase 2
21 English Lavender Phase 2
22
Enoxaparin Approved 9005-49-6 772
23
Aspirin Approved, Vet_approved 50-78-2 2244
24 Liver Extracts
25 Vaccines
26 polysaccharide-K
27 Ginkgo
28 Antiviral Agents

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 A Randomized Controlled Trial Comparing the Effectiveness of Individual vs. Household Treatment for Scabies in Lambaréné, Gabon Completed NCT04205669 Phase 4 Benzyl Benzoate 25% Topical Application Lotion
2 Impact of Combined Azithromycin and Ivermectin Mass Drug Administration for Yaws and Scabies - Impact on Impetigo and Skin Microbiology Completed NCT02775617 Phase 4 Ivermectin;Azithromycin;Permethrin
3 A Randomized Controlled Double-blind Trial Assessing the Efficacy of a 400 ug/kg Ivermectin Regime in Patients With Crusted Scabies as Compared to a 200 ug/kg Unknown status NCT02841215 Phase 3 Ivermectin 200 µg/kg;Ivermectin 400 µg/kg
4 Oral Ivermectin Versus Topical Permethrin to Treat Scabies in Children: a Cluster Multicenter Randomized Trial Unknown status NCT02407782 Phase 3 Ivermectin;Permethrin
5 A Randomized, Double-Blind, Parallel-Design, Multiple-Site Study to Evaluate the Therapeutic Equivalence of Permethrin Cream, 5% to Elimite™ Cream 5% in the Treatment of Scabies Completed NCT02572986 Phase 3 Permethrin
6 A Randomized, Double-Blind, Parallel-Design, Multiple-Site Study to Evaluate the Therapeutic Equivalence of Permethrin Cream, 5% (Encube Ethicals) Compared to Elimite™ Cream (Permethrin) 5% (Prestium Pharma, Inc.) in the Treatment of Scabies Completed NCT03178942 Phase 3 Permethrin Cream, 5%;Elimite™ Cream (permethrin) 5%
7 Impact of Community Scabies Treatment on Head Lice Prevalence in the Solomon Islands Completed NCT03236168 Phase 3 Ivermectin;Permethrin 5%;Malathion Shampoo 0.5%
8 A Double Blind, Two Arm, Multicenter, Randomized, Parallel Group, Bioequivalence Study With Clinical Endpoints to Evaluate the Safety and Therapeutic Equivalence of Permethrin Cream 5% & Elimite™ in Subjects With Scabies Completed NCT03973775 Phase 3 Permethrin Cream 5%
9 A Cluster Randomised Trial of the Safety of Co-Administration of IDA (Ivermectin, Diethylcarbamazine and Albendazole) & Azithromycin for Integrated Treatment of Neglected Tropical Diseases Completed NCT03676140 Phase 3 Albendazole on Day 1;Ivermectin on Day 1;Diethylcarbamazine on day 1;Azithromycin on Day 1;Azithromycin on Day 8
10 A Phase 3, Randomized, Double Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of Natroba™ (Spinosad) for the Treatment of Scabies Completed NCT02485704 Phase 3 spinosad topical suspension, 0.9%
11 A Multi-center, Double-blind, Randomized, Parallel-group Study Comparing Permethrin Cream, 5% With Elimite™ in Patients With Active Scabies. Completed NCT02978508 Phase 3 Permethrin Cream, 5%;Elimite
12 Diagnosis of Demodex Blapharitis and Treatment With Ivermectin Gel 0.1%/ Metronidazole 1% Completed NCT02236403 Phase 3 Ivermectin 0.1% Metronidazole 1%
13 A Phase 3, Randomized, Double Blind, Placebo-Controlled Study to Assess the Safety, Efficacy and Pharmacokinetics of Natroba™ (Spinosad) for the Treatment of Scabies Completed NCT02485717 Phase 3 spinosad topical suspension, 0.9%
14 A Randomised, Double Blind, Double Dummy Study to Compare the Efficacy and Safety of a Single Administration of Ivermectin to a Single Administration of Permethrin for the Treatment of Scabies Completed NCT00262418 Phase 2 Administration of ivermectin or permethrin
15 A Multicenter, Randomized, Double-Blind, Parallel Group Comparison Study of the Safety and Efficacy of Permethrin Foam, 5% Versus Permethrin Foam, 4% Versus Vehicle in Subjects With Sarcoptes Scabiei Completed NCT02094716 Phase 2 Permethrin Foam 4%;Permethrin Foam 5%;Vehicle Foam
16 A Phase II, Randomized, Double-blind, Parallel Group Dose Finding Study of Single Oral Doses of Moxidectin in Adults With Scabies Recruiting NCT03905265 Phase 2 Moxidectin Oral Product
17 A Randomised, Double-blind, Placebo-controlled Trial to Assess the Safety, Pharmacokinetics, and Efficacy of Escalating Doses of Oral Ivermectin in Scabies Infected Children Weighing 5 to Less Than 15 Kilograms Not yet recruiting NCT04332068 Phase 2 Oral ivermectin;Permethrin Cream
18 Multicenter, Double-blind, Randomized, Placebo-controlled Study to Assess the Efficacy, Safety and Tolerability of Ivermectin in Mild Virus-positive Subjects (SARS-CoV)-2 With or Without Symptoms Not yet recruiting NCT04407507 Phase 2 Ivermectin;Placebo
19 PCR (Polymerase Chain Reaction) Assay for Diagnosis of Sarcoptes Scabiei Completed NCT02254564
20 East Arnhem Healthy Skin Project: A Regional Collaboration to Reduce Scabies, Skin Sores and Associated Chronic Diseases, Including Rheumatic Fever and Renal Disease, Among Australian Aboriginal Communities Completed NCT00884728
21 The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) Part 1: The Prevalence of Rheumatic Heart Disease, Pyoderma and Scabies in School Children in Fiji Completed NCT00284843
22 Veron Scabies Education and Eradication Program Completed NCT00604084 Ivermectin;Permethrin 5% lotion
23 The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) - Part 4 -The Prevalence of Group A Streptococcal Pyoderma and Scabies in Infants in Fiji Completed NCT00436891
24 Community Based Safety Study of 2-drug (Diethylcarbamazine and Albendazole) Versus 3-drug (Ivermectin, Diethylcarbamazine and Albendazole) Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji Completed NCT03177993 3 drug dose - IDA;3 drug dose - IDA with second dose of ivermectin;2 drug dose - DA
25 The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) Part 3: The Incidence of Group A Streptococcal Pharyngitis and the Prevalence of Pyoderma and Scabies in School Children in Fiji, and Establishing Immunologic Correlates of Protection for a J8 Vaccine Completed NCT00284882
26 First Description of a Severe Ivermectin Neurotoxicity in a Child Carrying ABCB1 Nonsense Mutations. Completed NCT04174469
27 Efficacy and Nutritional Assessment Following Albendazole and Combined Albendazole/Ivermectin Treatment for Intestinal Helminth Infections in Rural Guatemalan Schoolchildren Completed NCT00207753 albendazole vs. combined albendazole/ivermectin treatment
28 A 60-Day Clinical Study to Evaluate Nutrilite Ginko Biloba Cistanche Tablets in Relieving the Symptoms of Chronic Fatigue Syndromes Compared to Negative Control Completed NCT02807649
29 School-based Interventions to Promote Personal and Environmental Hygiene Among Children in Pakistan: Protocol for a Mixed Methods Study Recruiting NCT03942523
30 EVALUATION of Ivermectin Aspirin Dexametasone and Enoxaparin as Treatment of covid19 Active, not recruiting NCT04425863 Ivermectin 5 MG/ML
31 Effects of PlayStation®VR on the Health-Related Quality of Life in Stroke Patients Undergoing Inpatient Rehabilitation: a Pilot Study Enrolling by invitation NCT04441177

Search NIH Clinical Center for Scabies

Inferred drug relations via UMLS 71 / NDF-RT 50 :


ANISE OIL/CORIANDER OIL/LEMON OIL/ORANGE OIL
crotamiton
Ivermectin
Lindane
Permethrin
Piperonyl Butoxide

Genetic Tests for Scabies

Anatomical Context for Scabies

MalaCards organs/tissues related to Scabies:

40
Skin, Breast, T Cells, Testes, Liver, Kidney, Heart

Publications for Scabies

Articles related to Scabies:

(show top 50) (show all 3450)
# Title Authors PMID Year
1
A case of hyperkeratotic crusted scabies. 61 42
32134911 2020
2
Scabies crustosa. 42 61
32036855 2020
3
Recurrence rate of scabies in patients 14 years or older in Saudi Arabia. 61 42
31828279 2019
4
Trends in prevalence and incidence of scabies from 1990 to 2017: findings from the global Burden of disease study 2017. 61
32284022 2020
5
How to eliminate scabies parasites from fomites: A high-throughput ex vivo experimental study. 61
31857110 2020
6
Periungual scabies in infants: a tough reservoir of mites presenting with lamellar desquamation. 61
30850380 2020
7
'Loss of efficacy of topical 5% permethrin for treating scabies: an Austrian single-center study'. 61
32495666 2020
8
Epidemiological Evaluation of Scabies Cases Encountered in the Last Three Years as a Tertiary Health Center. 61
32482039 2020
9
Application errors associated with topical treatment of scabies: an observational study. 61
32469466 2020
10
A cross-sectional study of dermatological conditions in rural and urban Timor-Leste. 61
32542648 2020
11
Scabies: A Comprehensive Review and Current Perspectives. 61
32484302 2020
12
An extraordinary outbreak of scabies in turkey. 61
32491243 2020
13
Dermoscopic diagnosis of common scabies in an older man. 61
32559273 2020
14
Crotamiton, an Anti-Scabies Agent, Suppresses Histamine- and Chloroquine-Induced Itch Pathways in Sensory Neurons and Alleviates Scratching in Mice. 61
32536619 2020
15
[Increase of scabies and therapy resistance among German military personnel : An 8-year follow-up study in the Department of Dermatology of the Armed Forces Hospital Berlin, Germany (2012-2019)]. 61
32430543 2020
16
Sequential Histopathological Changes and Cytokine Expressions in Dogs Naturally Infested with Sarcoptes scabiei Mites. 61
32100229 2020
17
Serum TARC levels before and after treatment for pruritic scabies. 61
32484992 2020
18
Overdiagnosis of scabies and overprescribing of scabies treatment in a scabies-endemic region. 61
32578330 2020
19
Live-interactive teledermatology program in Taiwan: One-year experience serving a district hospital in rural Taitung County. 61
32563581 2020
20
A 8- year Bangladeshi girl with disseminated histoplasmosis, presented as chronic liver disease with portal hypertension: a rare case report. 61
32513141 2020
21
Visual Dermatology: The Fjord Sign in Crusted Scabies. 61
32564618 2020
22
12-year data on dermatologic cases in the Finnish Register of Occupational Diseases I: Distribution of different diagnoses and main causes of allergic contact dermatitis. 61
32037572 2020
23
A case of nodular scabies with atypical course. 61
32182386 2020
24
Estimating the global burden of scabies: what else do we need? 61
32358799 2020
25
Case of dipeptidyl peptidase 4 inhibitor-associated bullous pemphigoid that developed after a scabies infestation. 61
32415680 2020
26
Correction: Classic and Non-classic (Surrepticius) Scabies: Diagnostic and Treatment Considerations. 61
32377498 2020
27
Prevalence and associated factors of scabies in Ethiopia: systematic review and Meta-analysis. 61
32460770 2020
28
Management and Soil Conditions Influence Common Scab Severity on Potato Tubers Via Indirect Effects on Soil Microbial Communities. 61
31939718 2020
29
The in vitro antibacterial effect of permethrin and formaldehyde on Staphylococcus aureus. 61
32383305 2020
30
Efficacy and safety of a combination regimen of phenothrin and ivermectin lotion in patients with head lice in Okinawa, Japan. 61
32383287 2020
31
Impact of community treatment with ivermectin for the control of scabies on the prevalence of antibodies to Strongyloides stercoralis in children. 61
32421762 2020
32
[Scabies therapy in Germany : Results of a nationwide survey with a special focus on the efficacy of first-line therapy with permethrin]. 61
32144440 2020
33
Can Acitretin Be Effective Alone in the Treatment of Crusted Scabies? 61
32467501 2020
34
The explosion in scabies cases during COVID-19 pandemic. 61
32447797 2020
35
Physical illnesses associated with childhood homelessness: a literature review. 61
32385787 2020
36
Spectrum of skin diseases in Amerindian villages of the Upper Oyapock, French Guiana. 61
32227343 2020
37
Nosological profile of dermatological diseases in primary health care and dermatology secondary care in Florianópolis (2016-2017). 61
32482550 2020
38
Magnitude, characteristics and consequences of topical steroid misuse in rural North India: an observational study among dermatology outpatients. 61
32430446 2020
39
The effect of the "stay-at-home" policy on requests for dermatology outpatient clinic visits after the COVID-19 outbreak. 61
32401401 2020
40
Risankizumab-Aggravated Crusted Scabies in a Patient with Down Syndrome. 61
32378153 2020
41
Prevalence of Scabies and Impetigo 3 Years After Mass Drug Administration With Ivermectin and Azithromycin. 61
31131410 2020
42
Scabies crustosa in a recipient of an allogeneic stem cell transplantation. 61
32270442 2020
43
Ivermectin safety in infants and children under 15 kg treated for scabies: a multicentric observational study. 61
31344258 2020
44
Molecular profiling of Peru Balsam reveals active ingredients responsible for its pharmaceutical properties. 61
32316792 2020
45
[CME Dermatology 21: Scabies - Clinical Manifestation, Diagnosis and Therapy]. 61
32345172 2020
46
Diagnosis of Scabies Confirmed With Confocal Microscopy. 61
31395273 2020
47
Effectiveness and adverse events of ivermectin treatment for scabies in 30 infant patients: report from a German single centre. 61
32339346 2020
48
Oral ivermectin for infants and children under 15 kg appears to be a safe and effective treatment for scabies. 61
31885077 2020
49
Diagnostic value of the molecular detection of Sarcoptes scabiei from a skin scraping in patients with suspected scabies. 61
32255795 2020
50
In Vitro Activity of Beauvericin against All Developmental Stages of Sarcoptes scabiei. 61
32122897 2020

Variations for Scabies

Expression for Scabies

Search GEO for disease gene expression data for Scabies.

Pathways for Scabies

Pathways related to Scabies according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 TNFRSF8 MBL2 KITLG IL31 IL1A IL10
2
Show member pathways
13.6 TNFRSF8 KITLG IL1A IL10 FLNA CXCL8
3
Show member pathways
13.52 TNFRSF8 IL31 IL1A IL10 CXCL8 CSF3
4
Show member pathways
13.17 TNFRSF8 KITLG IL1A IL10 CXCL8 CSF3
5
Show member pathways
13.02 TNFRSF8 KITLG IL31 IL1A IL10 CXCL8
6
Show member pathways
12.72 IL1A IL10 CXCL8 CD4 CCL11
7
Show member pathways
12.39 TNFRSF8 KITLG IL1A IL10 FLNA CXCL8
8
Show member pathways
12.2 IL10 CXCL8 CCR6 CCL11
9
Show member pathways
12.12 KITLG IL1A IL10 CXCL8
10 11.86 KITLG IL10 CSF3 CD4
11 11.84 IL1A IL10 CXCL8 CCL11
12 11.75 KITLG IL1A CSF3 CD4
13 11.68 IL10 CD4 CCR6
14 11.66 KITLG GSTM1 CD4
15 11.64 IL1A IL10 CXCL8
16 11.53 CXCL8 CSF3 CCL11
17 11.42 IL10 CXCL8 CSF3
18 11.39 KITLG IL1A CSF3
19 11.31 IL1A IL10 CXCL8 CSF3
20 11.12 IL31 IL10 CD4 CCL11
21 10.89 KITLG IL1A IL10 CXCL8 CSF3 CCL11
22 10.72 IL1A IL10 CSF3 CD4

GO Terms for Scabies

Cellular components related to Scabies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 MBL2 KITLG IL31 IL1A IL10 CXCL8
2 extracellular region GO:0005576 9.32 MBL2 KITLG IL31 IL1A IL10 FLNA

Biological processes related to Scabies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.97 TNFRSF8 KITLG IL10 CXCL8 CSF3 CD4
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.61 KITLG CSF3 CD4
3 chemokine-mediated signaling pathway GO:0070098 9.5 CXCL8 CCR6 CCL11
4 cytokine-mediated signaling pathway GO:0019221 9.5 IL31 IL1A IL10 CXCL8 CSF3 CD4
5 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.46 IL1A CD4
6 cellular response to lipopolysaccharide GO:0071222 9.46 IL1A IL10 CXCL8 CSF3
7 response to molecule of bacterial origin GO:0002237 9.4 IL10 CXCL8
8 ectopic germ cell programmed cell death GO:0035234 9.26 KITLG IL1A
9 immune response GO:0006955 9.23 IL1A IL10 CXCL8 CSF3 CFP CD4

Molecular functions related to Scabies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 KITLG IL31 IL1A IL10 CXCL8 CSF3

Sources for Scabies

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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