MCID: SCB001
MIFTS: 51

Scabies

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Scabies

MalaCards integrated aliases for Scabies:

Name: Scabies 12 76 43 3 44 15 73
Infestation by Sarcoptes Scabiei Var Hominis 12
Infestation by Sarcoptes Scabiei 12
Sarcoptic Itch 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8295
ICD10 33 B86
ICD9CM 35 133.0
MeSH 44 D012532
NCIt 50 C34998
SNOMED-CT 68 67172004
UMLS 73 C0036262

Summaries for Scabies

MedlinePlus : 43 Scabies is an itchy skin condition caused by the microscopic mite Sarcoptes scabei. It is common all over the world, and can affect anyone. Scabies spreads quickly in crowded conditions where there is frequent skin-to-skin contact between people. Hospitals, child-care centers, and nursing homes are examples. Scabies can easily infect sex partners and other household members. Sharing clothes, towels, and bedding can sometimes spread scabies. This can happen much more easily when the infested person has crusted scabies. You cannot get scabies from a pet. Pets get a different mite infection called mange. Symptoms are Pimple-like irritations or a rash Intense itching, especially at night Sores caused by scratching Your health care provider diagnoses scabies by looking at the skin rash and finding burrows in the skin. Several lotions are available to treat scabies. The infected person's clothes, bedding and towels should be washed in hot water and dried in a hot dryer. Treatment is also recommended for household members and sexual partners. Centers for Disease Control and Prevention

MalaCards based summary : Scabies, also known as infestation by sarcoptes scabiei var hominis, is related to psoriasis and allergic contact dermatitis, and has symptoms including fever, pruritus and exanthema. An important gene associated with Scabies is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Ivermectin and Permethrin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotype is immune system.

Disease Ontology : 12 A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

CDC : 3 Human scabies is caused by an infestation of the skin by the human itch mite (Sarcoptes scabiei var. hominis). The microscopic scabies mite burrows into the upper layer of the skin where it lives and lays its eggs. The most common symptoms of scabies are intense itching and a pimple-like skin rash. The scabies mite usually is spread by direct, prolonged, skin-to-skin contact with a person who has scabies.

Wikipedia : 76 Scabies, also known as the seven-year itch, is a contagious skin infestation by the mite Sarcoptes... more...

Related Diseases for Scabies

Diseases related to Scabies via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
# Related Disease Score Top Affiliating Genes
1 psoriasis 30.1 CXCL8 IL10 IL1A
2 allergic contact dermatitis 30.1 CXCL8 IL10
3 arthritis 30.0 CXCL8 IL10 IL1A
4 contact dermatitis 30.0 CXCL8 IL10 IL1A
5 tungiasis 29.9 CXCL8 IL10
6 chronic graft versus host disease 29.8 IL10 IL1A
7 dermatitis, atopic 29.8 CCL11 CXCL8 IL10
8 endocarditis 29.7 CXCL8 IL10
9 rheumatic fever 29.5 IL10 MBL2
10 bacterial vaginosis 29.4 CXCL8 IL1A MBL2
11 skin disease 29.3 CCL11 CXCL8 IL10 IL1A
12 asthma 29.1 CCL11 CXCL8 IL10 IL1A KITLG
13 norwegian scabies 12.7
14 pyoderma 11.4
15 impetigo 10.3
16 bullous pemphigoid 10.3
17 acquired immunodeficiency syndrome 10.2
18 dermatitis 10.2
19 cyclic neutropenia 10.2 CXCL8 KITLG
20 acute transverse myelitis 10.2 CXCL8 IL10
21 transverse myelitis 10.2 CXCL8 IL10
22 pouchitis 10.2 CXCL8 IL10
23 neurosyphilis 10.2 CXCL8 IL10
24 necatoriasis 10.2 CXCL8 IL10
25 trichuriasis 10.2 CXCL8 IL10
26 funisitis 10.2 CXCL8 IL10
27 clonorchiasis 10.2 CXCL8 IL10
28 retinitis pigmentosa 44 10.2 CXCL8 IL10
29 congenital disorder of glycosylation, type iic 10.2 CXCL8 KITLG
30 mycetoma 10.2 CXCL8 IL10
31 leukoregulin 10.2 CXCL8 IL1A
32 aseptic meningitis 10.2 CXCL8 IL10
33 primary peritoneal carcinoma 10.2 CXCL8 IL10
34 acute pyelonephritis 10.2 CXCL8 IL10
35 pyelonephritis 10.2 CXCL8 IL10
36 bacterial sepsis 10.2 CXCL8 IL10
37 sebaceous gland disease 10.2 CXCL8 IL1A
38 pulpitis 10.2 CXCL8 IL1A
39 prostatitis 10.2 CXCL8 IL10
40 oral candidiasis 10.2 CXCL8 IL1A
41 leptospirosis 10.2 CXCL8 IL10
42 papillary conjunctivitis 10.2 CCL11 CXCL8
43 conjunctivitis 10.2 CCL11 CXCL8
44 peptic ulcer disease 10.2 CXCL8 IL10
45 giant papillary conjunctivitis 10.2 CCL11 CXCL8
46 bullous keratopathy 10.2 CXCL8 IL1A
47 brucellosis 10.1 CXCL8 IL10
48 testicular disease 10.1 IL10 KITLG
49 shigellosis 10.1 CXCL8 IL10
50 appendicitis 10.1 CXCL8 IL10

Comorbidity relations with Scabies via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Heart Disease Ischemic Heart Disease
Protein-Energy Malnutrition Schizophreniform Disorder

Graphical network of the top 20 diseases related to Scabies:



Diseases related to Scabies

Symptoms & Phenotypes for Scabies

UMLS symptoms related to Scabies:


fever, pruritus, exanthema

MGI Mouse Phenotypes related to Scabies:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.1 CCL11 CFP IL10 IL1A KITLG MBL2

Drugs & Therapeutics for Scabies

Drugs for Scabies (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 70288-86-7 6474909
2
Permethrin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 52645-53-1 40326
3
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
4 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
5 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
6
Malathion Approved, Investigational Phase 3 121-75-5 4004
7
Metronidazole Approved Phase 3 443-48-1 4173
8
Albendazole Approved, Vet_approved Phase 3,Not Applicable 54965-21-8 2082
9
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 3,Not Applicable 90-89-1 3052
10 Cholinergic Agents Phase 3
11 Neurotransmitter Agents Phase 3
12 Cholinesterase Inhibitors Phase 3
13 Antiprotozoal Agents Phase 3,Not Applicable
14 Anthelmintics Phase 3,Not Applicable
15 Lipoxygenase Inhibitors Phase 3,Not Applicable
16 Antimitotic Agents Phase 3,Not Applicable
17 Dermatologic Agents Phase 3
18 Emollients Phase 3
19 Anti-Bacterial Agents Phase 3
20 Liver Extracts Not Applicable
21 Vaccines

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Azithromycin - Ivermectin Mass Drug Administration for Skin Disease Completed NCT02775617 Phase 4 Ivermectin;Azithromycin;Permethrin
2 Oral Ivermectin Versus Topical Permethrin to Treat Scabies in Children Unknown status NCT02407782 Phase 3 Ivermectin;Permethrin
3 Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies Completed NCT02485704 Phase 3 spinosad topical suspension, 0.9%
4 Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies Completed NCT02485717 Phase 3 spinosad topical suspension, 0.9%
5 A Study to Evaluate the Therapeutic Equivalence of Generic Permethrin Cream 5% to Elimite® in the Treatment of Scabies Completed NCT02572986 Phase 3 Permethrin
6 Bio-equivalence Study Comparing Permethrin Cream, 5% With Elimite in Patients With Active Scabies. Completed NCT02978508 Phase 3 Permethrin Cream, 5%;Elimite
7 Impact of Community Scabies Treatment on Head Lice Prevalence in the Solomon Islands Completed NCT03236168 Phase 3 Ivermectin;Permethrin 5%;Malathion Shampoo 0.5%
8 Treatment of Demodex Blepharitis With Ivermectin Gel 0.1% Plus Metronidazole 1% Completed NCT02236403 Phase 3 Ivermectin 0.1% Metronidazole 1%
9 Multiple-Site Study to Evaluate the Therapeutic Equivalence of Permethrin Cream, 5% in the Treatment of Scabies Active, not recruiting NCT03178942 Phase 3 Permethrin;Elimite 5% Cream
10 Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies Not yet recruiting NCT02841215 Phase 3 Ivermectin 200 µg/kg;Ivermectin 400 µg/kg
11 Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs ) Not yet recruiting NCT03676140 Phase 3 Albendazole on Day 1;Ivermectin on Day 1;Diethylcarbamazine on day 1;Azithromycin on Day 1;Azithromycin on Day 8
12 A Dose Ranging Vehicle Controlled Study to Determine the Safety and Efficacy of Permethrin Foam, 5% and Permethrin Foam, 4% for the Treatment of Scabies Completed NCT02094716 Phase 2 Permethrin Foam 4%;Permethrin Foam 5%;Vehicle Foam
13 Comparison of the Efficacy and Safety of Ivermectin to Permethrin Completed NCT00262418 Phase 2 Administration of ivermectin or permethrin
14 Veron Scabies Education and Eradication Program Completed NCT00604084 Not Applicable Ivermectin;Permethrin 5% lotion
15 Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji Completed NCT03177993 Not Applicable 3 drug dose - IDA;3 drug dose - IDA with second dose of ivermectin;2 drug dose - DA
16 PCR (Polymerase Chain Reaction) Assay for Diagnosis of Sarcoptes Scabiei Completed NCT02254564
17 Prevalence of RHD, Pyoderma and Scabies in Children in Fiji Completed NCT00284843
18 Streptococcal Infections in Fiji - Prevalence of Group A Streptococcal Pyoderma and Scabies in Infants in Fiji Completed NCT00436891
19 Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory Completed NCT00884728
20 Incidence of Group A Strep Pharyngitis in School Children in Fiji Completed NCT00284882
21 Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections Completed NCT00207753 Not Applicable albendazole vs. combined albendazole/ivermectin treatment

Search NIH Clinical Center for Scabies

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: scabies

Genetic Tests for Scabies

Anatomical Context for Scabies

MalaCards organs/tissues related to Scabies:

41
Skin, T Cells, Testes, Liver, Heart, Kidney, Lung

Publications for Scabies

Articles related to Scabies:

(show top 50) (show all 1095)
# Title Authors Year
1
Scabies and Pruritus-A Historical Review. ( 29801071 )
2018
2
Comparing the diagnostic properties of skin scraping, adhesive tape, and dermoscopy in diagnosing scabies. ( 29945263 )
2018
3
Treatment of scabies using a tea tree oil-based gel formulation in Australian Aboriginal children: protocol for a randomised controlled trial. ( 29858405 )
2018
4
Scabies is strongly associated with acute rheumatic fever in a cohort study of Auckland children. ( 29442387 )
2018
5
Crusted Scabies in Systemic Sclerosis with Plasma Cell Dyscrasia. ( 29854644 )
2018
6
Nail infestation: an atypical presentation of typical scabies. ( 29893225 )
2018
7
Efficacy and Pharmacokinetics Evaluation of a Single Oral Dose of Afoxolaner against <i>Sarcoptes scabiei</i> in the Porcine Scabies Model for Human Infestation. ( 29914951 )
2018
8
Why is the back so rarely involved in scabies? ( 29781261 )
2018
9
Calculation of the age of the first infection for skin sores and scabies in five remote communities in northern Australia. ( 29734959 )
2018
10
Ivermectin and permethrin for treating scabies. ( 29608022 )
2018
11
Scabies Itch. ( 29929601 )
2018
12
The Epidemiology of Scabies and Pediculosis in Kayseri. ( 29780005 )
2018
13
Increased risk of psoriasis following scabies infection: A nationwide population-based matched-cohort study. ( 29356052 )
2018
14
Ivermectin versus permethrin in the treatment of scabies: A systematic review and meta-analysis of randomized controlled trials. ( 29241784 )
2018
15
Skin bacterial colonizations and superinfections in immunocompetent patients with scabies. ( 29974940 )
2018
16
Treatment of Scabies and Pediculosis in Health Education Publications and Folk Medicine of Eastern Croatia - Slavonija, Baranja, and Western Srijem County. ( 29782297 )
2018
17
Atypical crusted scabies in a patient with chronic liver disease caused by hepatitis B and D viruses. ( 29723368 )
2018
18
Consensus criteria for the diagnosis of scabies: A Delphi study of international experts. ( 29795566 )
2018
19
Tackling scabies: novel agents for a neglected disease. ( 29663338 )
2018
20
Efficacy of ivermectin mass-drug administration to control scabies in asylum seekers in the Netherlands: A retrospective cohort study between January 2014 - March 2016. ( 29771941 )
2018
21
Management of a family outbreak of scabies with high risk of spread to other community and hospital facilities. ( 29397231 )
2018
22
Effects of AttM lactonase on the pathogenicity of Streptomyces scabies. ( 29897616 )
2018
23
The efficacy of a nested PCR in detecting cytochrome c oxidase subunit 1 gene of Sarcoptes scabiei var. Hominis for diagnosing scabies. ( 29624634 )
2018
24
Scabies and impetigo in Timor-Leste: A school screening study in two districts. ( 29852002 )
2018
25
Impact of Ivermectin Mass Drug Administration for Lymphatic Filariasis on Scabies in Eight Villages in Kongwa District, Tanzania. ( 30062986 )
2018
26
Scabies mimicking graft versus host disease in a hematopoietic cell transplant recipient. ( 30428645 )
2018
27
Randomised trial of community treatment with azithromycin and ivermectin mass drug administration for control of scabies and impetigo. ( 29985978 )
2018
28
Is impetigo a missed opportunity for scabies treatment? ( 30161116 )
2018
29
Crusted (Norwegian) Scabies: Nine-Month Course With Iatrogenic Immunosuppression. ( 30365596 )
2018
30
Crusted scabies masquerading as psoriasis plaques in a patient suffering from burn scars. ( 30142723 )
2018
31
An Undiagnosed Index Case Leading to a Nosocomial Scabies Outbreak: How Mass Single-Dose Ivermectin Treatment Can Help Control a Nosocomial Epidemic. ( 29457578 )
2018
32
Design of a Topically Applied Gel Spray Formulation with Ivermectin Using a Novel Low Molecular Weight Gelling Agent, Palmitoyl-Glycine-Histidine, to Treat Scabies. ( 29491265 )
2018
33
Comment on "Scabies in babies". ( 29575080 )
2018
34
Prevalence of Nail Scabies: A French Prospective Multicenter Study. ( 29576324 )
2018
35
Scabies in residential care homes: Modelling, inference and interventions for well-connected population sub-units. ( 29579037 )
2018
36
Crusted scabies in a patient with methamphetamine abuse. ( 29984289 )
2018
37
Scabies-An Ancient Disease With Unanswered Questions in Modern Times. ( 30027219 )
2018
38
Scabies and risk of skin sores in remote Australian Aboriginal communities: A self-controlled case series study. ( 30044780 )
2018
39
Scabies Outbreak Investigation and Risk Factors in East Badewacho District, Southern Ethiopia: Unmatched Case Control Study. ( 30046302 )
2018
40
Diagnosis, treatment, and control of scabies: can we do better? ( 30068496 )
2018
41
Scabies outbreaks in ten care homes for elderly people: a prospective study of clinical features, epidemiology, and treatment outcomes. ( 30068499 )
2018
42
Scabies. ( 30120479 )
2018
43
Scalp-to-toes application of permethrin for patients with scabies. ( 30142746 )
2018
44
A biological model of scabies infection dynamics and treatment informs mass drug administration strategies to increase the likelihood of elimination. ( 30149021 )
2018
45
Image Gallery: Capillaroscopy for noninvasive scabies diagnosis. ( 30222885 )
2018
46
Proteomic Response to Thaxtomin Phytotoxin Elicitor Cellobiose and to Deletion of Cellulose Utilization Regulator CebR in Streptomyces scabies. ( 30229651 )
2018
47
Impact of ivermectin administered for scabies treatment on the prevalence of head lice in Atoifi, Solomon Islands. ( 30252856 )
2018
48
Scabies in Resource-Poor Communities in Nasarawa State, Nigeria: Epidemiology, Clinical Features and Factors Associated with Infestation. ( 30274455 )
2018
49
Cushing Syndrome due to Inappropriate Corticosteroid Topical Treatment of Undiagnosed Scabies. ( 30274478 )
2018
50
Control Strategies for Scabies. ( 30274494 )
2018

Variations for Scabies

Expression for Scabies

Search GEO for disease gene expression data for Scabies.

Pathways for Scabies

Pathways related to Scabies according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 CCL11 CFP CXCL8 IL10 IL1A KITLG
2
Show member pathways
13.19 CCL11 CXCL8 IL10 IL1A KITLG
3
Show member pathways
13.07 CCL11 CXCL8 IL10 IL1A KITLG
4
Show member pathways
13 CCL11 CXCL8 IL10 IL1A KITLG
5
Show member pathways
12.9 CCL11 CXCL8 IL10 IL1A KITLG
6
Show member pathways
12.55 CCL11 CXCL8 IL10 IL1A
7
Show member pathways
11.91 CXCL8 IL10 IL1A KITLG
8 11.87 CXCL8 IL10 IL1A
9 11.43 CXCL8 IL10 IL1A
10 11.42 CCL11 IL10
11 11.41 CCL11 CXCL8
12
Show member pathways
11.4 CXCL8 IL1A
13
Show member pathways
11.37 CCL11 CXCL8 IL10 IL1A KITLG
14 11.35 IL10 MBL2
15 11.28 CXCL8 IL10
16 11.27 IL1A KITLG
17 11.25 CCL11 CXCL8
18 11.23 CCL11 IL10
19 11.19 CXCL8 IL10 IL1A
20 11.09 IL10 IL1A
21 11 IL10 IL1A
22 10.98 CCL11 CXCL8 IL10 IL1A
23 10.69 CCL11 CXCL8 IL10 IL1A
24 10.56 CCL11 CXCL8 IL10 IL1A KITLG

GO Terms for Scabies

Cellular components related to Scabies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 CFP CXCL8 IL10 IL1A KITLG
2 extracellular space GO:0005615 9.17 CCL11 CFP CXCL8 IL10 IL1A KITLG

Biological processes related to Scabies according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.69 CFP IL10 MBL2
2 inflammatory response GO:0006954 9.62 CCL11 CXCL8 IL10 IL1A
3 positive regulation of angiogenesis GO:0045766 9.61 CCL11 CXCL8 IL1A
4 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.49 IL1A KITLG
5 positive regulation of cytokine secretion GO:0050715 9.48 IL10 IL1A
6 leukocyte chemotaxis GO:0030595 9.46 CXCL8 IL10
7 cytokine-mediated signaling pathway GO:0019221 9.46 CCL11 CXCL8 IL10 IL1A
8 negative regulation of growth of symbiont in host GO:0044130 9.4 IL10 MBL2
9 response to molecule of bacterial origin GO:0002237 9.37 CXCL8 IL10
10 immune response GO:0006955 9.35 CCL11 CFP CXCL8 IL10 IL1A
11 ectopic germ cell programmed cell death GO:0035234 9.26 IL1A KITLG
12 regulation of signaling receptor activity GO:0010469 9.02 CCL11 CXCL8 IL10 IL1A KITLG

Molecular functions related to Scabies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL11 CXCL8 IL10 IL1A KITLG
2 chemokine activity GO:0008009 8.96 CCL11 CXCL8

Sources for Scabies

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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