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MCID: SCB001
MIFTS: 50

Scabies

Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Scabies

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MalaCards integrated aliases for Scabies:

Name: Scabies 12 76 43 3 44 15 73
Infestation by Sarcoptes Scabiei Var Hominis 12
Infestation by Sarcoptes Scabiei 12
Sarcoptic Itch 12

Classifications:

MalaCards categories:
Global: Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:8295
ICD10 33 B86
ICD9CM 35 133.0
MeSH 44 D012532
NCIt 50 C34998
UMLS 73 C0036262
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Summaries for Scabies

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MedlinePlus : 43 Scabies is an itchy skin condition caused by the microscopic mite Sarcoptes scabei. It is common all over the world, and can affect anyone. Scabies spreads quickly in crowded conditions where there is frequent skin-to-skin contact between people. Hospitals, child-care centers, and nursing homes are examples. Scabies can easily infect sex partners and other household members. Sharing clothes, towels, and bedding can sometimes spread scabies. This can happen much more easily when the infested person has crusted scabies. You cannot get scabies from a pet. Pets get a different mite infection called mange. Symptoms are Pimple-like irritations or a rash Intense itching, especially at night Sores caused by scratching Your health care provider diagnoses scabies by looking at the skin rash and finding burrows in the skin. Several lotions are available to treat scabies. The infected person's clothes, bedding and towels should be washed in hot water and dried in a hot dryer. Treatment is also recommended for household members and sexual partners. Centers for Disease Control and Prevention

MalaCards based summary : Scabies, also known as infestation by sarcoptes scabiei var hominis, is related to tungiasis and allergic contact dermatitis, and has symptoms including exanthema, fever and pruritus. An important gene associated with Scabies is IL1A (Interleukin 1 Alpha), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Ivermectin and Permethrin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotype is immune system.

Disease Ontology : 12 A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

CDC : 3 Human scabies is caused by an infestation of the skin by the human itch mite (Sarcoptes scabiei var. hominis). The microscopic scabies mite burrows into the upper layer of the skin where it lives and lays its eggs. The most common symptoms of scabies are intense itching and a pimple-like skin rash. The scabies mite usually is spread by direct, prolonged, skin-to-skin contact with a person who has scabies.

Wikipedia : 76 Scabies, also known as the seven-year itch, is a contagious skin infestation by the mite Sarcoptes... more...

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Related Diseases for Scabies

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Diseases related to Scabies via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 187)
# Related Disease Score Top Affiliating Genes
1 tungiasis 30.2 CXCL8 IL10
2 allergic contact dermatitis 30.1 CXCL8 IL10
3 contact dermatitis 29.9 CXCL8 IL10 IL1A
4 arthritis 29.9 CXCL8 IL10 IL1A
5 endocarditis 29.5 CXCL8 IL10
6 psoriasis 29.3 CXCL8 IL10 IL1A
7 dermatitis, atopic 29.3 CCL11 CXCL8 IL10
8 asthma 26.8 CCL11 CXCL8 GSTM1 IL10 IL1A KITLG
9 norwegian scabies 12.6
10 chronic graft versus host disease 10.6 IL10 IL1A
11 multidrug-resistant tuberculosis 10.6 IL10 IL1A
12 post-transplant lymphoproliferative disease 10.6 IL10 IL1A
13 leukoregulin 10.6 CXCL8 IL1A
14 idiopathic neutropenia 10.6 IL10 IL1A
15 keratoconjunctivitis sicca 10.6 IL10 IL1A
16 acute transverse myelitis 10.5 CXCL8 IL10
17 sebaceous gland disease 10.5 CXCL8 IL1A
18 pouchitis 10.5 CXCL8 IL10
19 neurosyphilis 10.5 CXCL8 IL10
20 necatoriasis 10.5 CXCL8 IL10
21 funisitis 10.5 CXCL8 IL10
22 trichuriasis 10.5 CXCL8 IL10
23 clonorchiasis 10.5 CXCL8 IL10
24 pulpitis 10.5 CXCL8 IL1A
25 transverse myelitis 10.5 CXCL8 IL10
26 oral candidiasis 10.5 CXCL8 IL1A
27 bullous keratopathy 10.5 CXCL8 IL1A
28 mycetoma 10.5 CXCL8 IL10
29 cytomegalovirus infection 10.5 CXCL8 IL10
30 primary peritoneal carcinoma 10.5 CXCL8 IL10
31 acute pyelonephritis 10.5 CXCL8 IL10
32 viral encephalitis 10.4 CXCL8 IL10
33 prostatitis 10.4 CXCL8 IL10
34 leptospirosis 10.4 CXCL8 IL10
35 brucellosis 10.4 CXCL8 IL10
36 pyelonephritis 10.4 CXCL8 IL10
37 peptic ulcer disease 10.4 CXCL8 IL10
38 tonsillitis 10.4 CXCL8 IL1A
39 appendicitis 10.4 CXCL8 IL10
40 dengue hemorrhagic fever 10.4 CXCL8 IL10
41 silicosis 10.4 CXCL8 IL1A
42 shigellosis 10.4 CXCL8 IL10
43 extrinsic allergic alveolitis 10.3 CXCL8 IL10
44 cryptosporidiosis 10.3 CCL11 IL1A
45 chorioamnionitis 10.3 CXCL8 IL1A
46 oligospermia 10.3 GSTM1 KITLG
47 adult respiratory distress syndrome 10.3 CXCL8 IL10
48 bronchiolitis obliterans 10.3 CXCL8 IL10
49 pulmonary edema 10.3 CXCL8 IL10
50 papillary conjunctivitis 10.2 CCL11 CXCL8

Comorbidity relations with Scabies via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Heart Disease Ischemic Heart Disease
Protein-Energy Malnutrition Schizophreniform Disorder

Graphical network of the top 20 diseases related to Scabies:



Diseases related to Scabies
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Symptoms & Phenotypes for Scabies

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UMLS symptoms related to Scabies:


exanthema, fever, pruritus

MGI Mouse Phenotypes related to Scabies:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.1 CCL11 CFP IL10 IL1A KITLG MBL2
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Drugs & Therapeutics for Scabies

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Drugs for Scabies (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 70288-86-7 6474909
2
Permethrin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 52645-53-1 40326
3
Azithromycin Approved Phase 4 83905-01-5 55185 447043
4 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
5 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
6
Malathion Approved, Investigational Phase 3 121-75-5 4004
7
Metronidazole Approved Phase 3 443-48-1 4173
8 Cholinergic Agents Phase 3
9 Cholinesterase Inhibitors Phase 3
10 Neurotransmitter Agents Phase 3
11 Antiprotozoal Agents Phase 3,Not Applicable
12 Dermatologic Agents Phase 3
13 Emollients Phase 3
14
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
15
Diethylcarbamazine Approved, Investigational, Vet_approved Not Applicable 90-89-1 3052
16 Vaccines
17 Anthelmintics Not Applicable
18 Antimitotic Agents Not Applicable
19 Liver Extracts Not Applicable
20 Lipoxygenase Inhibitors Not Applicable

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Azithromycin - Ivermectin Mass Drug Administration for Skin Disease Completed NCT02775617 Phase 4 Ivermectin;Azithromycin;Permethrin
2 Oral Ivermectin Versus Topical Permethrin to Treat Scabies in Children Unknown status NCT02407782 Phase 3 Ivermectin;Permethrin
3 A Study to Evaluate the Therapeutic Equivalence of Generic Permethrin Cream 5% to Elimite® in the Treatment of Scabies Completed NCT02572986 Phase 3 Permethrin
4 Bio-equivalence Study Comparing Permethrin Cream, 5% With Elimite in Patients With Active Scabies. Completed NCT02978508 Phase 3 Permethrin Cream, 5%;Elimite
5 Impact of Community Scabies Treatment on Head Lice Prevalence in the Solomon Islands Completed NCT03236168 Phase 3 Ivermectin;Permethrin 5%;Malathion Shampoo 0.5%
6 Treatment of Demodex Blepharitis With Ivermectin Gel 0.1% Plus Metronidazole 1% Completed NCT02236403 Phase 3 Ivermectin 0.1% Metronidazole 1%
7 Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies Active, not recruiting NCT02485704 Phase 3 spinosad topical suspension, 0.9%
8 Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies Active, not recruiting NCT02485717 Phase 3 spinosad topical suspension, 0.9%
9 Multiple-Site Study to Evaluate the Therapeutic Equivalence of Permethrin Cream, 5% in the Treatment of Scabies Active, not recruiting NCT03178942 Phase 3 Permethrin;Elimite 5% Cream
10 Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies Not yet recruiting NCT02841215 Phase 3 Ivermectin 200 µg/kg;Ivermectin 400 µg/kg
11 A Dose Ranging Vehicle Controlled Study to Determine the Safety and Efficacy of Permethrin Foam, 5% and Permethrin Foam, 4% for the Treatment of Scabies Completed NCT02094716 Phase 2 Permethrin Foam 4%;Permethrin Foam 5%;Vehicle Foam
12 Comparison of the Efficacy and Safety of Ivermectin to Permethrin Completed NCT00262418 Phase 2 Administration of ivermectin or permethrin
13 Veron Scabies Education and Eradication Program Completed NCT00604084 Not Applicable Ivermectin;Permethrin 5% lotion
14 PCR (Polymerase Chain Reaction) Assay for Diagnosis of Sarcoptes Scabiei Completed NCT02254564
15 Prevalence of RHD, Pyoderma and Scabies in Children in Fiji Completed NCT00284843
16 Streptococcal Infections in Fiji - Prevalence of Group A Streptococcal Pyoderma and Scabies in Infants in Fiji Completed NCT00436891
17 Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory Completed NCT00884728
18 Incidence of Group A Strep Pharyngitis in School Children in Fiji Completed NCT00284882
19 Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections Completed NCT00207753 Not Applicable albendazole vs. combined albendazole/ivermectin treatment
20 Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji Recruiting NCT03177993 Not Applicable 3 drug dose - IDA;3 drug dose - IDA with second dose of ivermectin;2 drug dose - DA

Search NIH Clinical Center for Scabies

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: scabies

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Genetic Tests for Scabies

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Anatomical Context for Scabies

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MalaCards organs/tissues related to Scabies:

41
Skin, T Cells, Testes, Liver, Kidney, Colon, Brain
Sources

Publications for Scabies

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Articles related to Scabies:

(show top 50) (show all 769)
# Title Authors Year
1
Scabies and Pruritus-A Historical Review. ( 29801071 )
2018
2
Comparing the diagnostic properties of skin scraping, adhesive tape, and dermoscopy in diagnosing scabies. ( 29945263 )
2018
3
Treatment of scabies using a tea tree oil-based gel formulation in Australian Aboriginal children: protocol for a randomised controlled trial. ( 29858405 )
2018
4
Scabies is strongly associated with acute rheumatic fever in a cohort study of Auckland children. ( 29442387 )
2018
5
Crusted Scabies in Systemic Sclerosis with Plasma Cell Dyscrasia. ( 29854644 )
2018
6
Nail infestation: an atypical presentation of typical scabies. ( 29893225 )
2018
7
Efficacy and Pharmacokinetics Evaluation of a Single Oral Dose of Afoxolaner against <i>Sarcoptes scabiei</i> in the Porcine Scabies Model for Human Infestation. ( 29914951 )
2018
8
Why is the back so rarely involved in scabies? ( 29781261 )
2018
9
Calculation of the age of the first infection for skin sores and scabies in five remote communities in northern Australia. ( 29734959 )
2018
10
Ivermectin and permethrin for treating scabies. ( 29608022 )
2018
11
Scabies Itch. ( 29929601 )
2018
12
The Epidemiology of Scabies and Pediculosis in Kayseri. ( 29780005 )
2018
13
Increased risk of psoriasis following scabies infection: A nationwide population-based matched-cohort study. ( 29356052 )
2018
14
Ivermectin versus permethrin in the treatment of scabies: A systematic review and meta-analysis of randomized controlled trials. ( 29241784 )
2018
15
Skin bacterial colonizations and superinfections in immunocompetent patients with scabies. ( 29974940 )
2018
16
Treatment of Scabies and Pediculosis in Health Education Publications and Folk Medicine of Eastern Croatia - Slavonija, Baranja, and Western Srijem County. ( 29782297 )
2018
17
Atypical crusted scabies in a patient with chronic liver disease caused by hepatitis B and D viruses. ( 29723368 )
2018
18
Consensus criteria for the diagnosis of scabies: A Delphi study of international experts. ( 29795566 )
2018
19
Tackling scabies: novel agents for a neglected disease. ( 29663338 )
2018
20
Efficacy of ivermectin mass-drug administration to control scabies in asylum seekers in the Netherlands: A retrospective cohort study between January 2014 - March 2016. ( 29771941 )
2018
21
Management of a family outbreak of scabies with high risk of spread to other community and hospital facilities. ( 29397231 )
2018
22
Effects of AttM lactonase on the pathogenicity of Streptomyces scabies. ( 29897616 )
2018
23
The efficacy of a nested PCR in detecting cytochrome c oxidase subunit 1 gene of Sarcoptes scabiei var. Hominis for diagnosing scabies. ( 29624634 )
2018
24
Scabies and impetigo in Timor-Leste: A school screening study in two districts. ( 29852002 )
2018
25
Scabies in babies. ( 28833468 )
2017
26
The Epidemiology of Scabies and Impetigo in Relation to Demographic and Residential Characteristics: Baseline Findings from the Skin Health Intervention Fiji Trial. ( 28722612 )
2017
27
The prevalence and association with health-related quality of life of tungiasis and scabies in schoolchildren in southern Ethiopia. ( 28771469 )
2017
28
Noodle pattern: a new dermoscopic pattern for crusted scabies (Norwegian scabies). ( 28758268 )
2017
29
Comparative Efficacy of Topical Pertmehrin, Crotamiton and Sulfur Ointment in Treatment of Scabies. ( 29018829 )
2017
30
Scabies and mortality. ( 29173877 )
2017
31
Leukocytoclastic vasculitis associated with crusted scabies. ( 29199154 )
2017
32
Scabies outbreak among healthcare workers in a German acute care hospital. ( 28989526 )
2017
33
Clinical diagnosis of crusted scabies: Reverse focal pattern of plantar keratoderma. ( 29243244 )
2017
34
What's eating you? scabies in the developing world. ( 29232427 )
2017
35
Biosynthesis and evolution of coronafacoyl phytotoxin production in the common scab pathogen Streptomyces scabies. ( 28754703 )
2017
36
Scabies, crusted (Norwegian) scabies and the diagnosis of mite sensitisation. ( 29279260 )
2017
37
Are scabies and impetigo &amp;quot;normalised&amp;quot;? A cross-sectional comparative study of hospitalised children in northern Australia assessing clinical recognition and treatment of skin infections. ( 28671945 )
2017
38
Expression and characterisation of a Sarcoptes scabiei protein tyrosine kinase as a potential antigen for scabies diagnosis. ( 28852108 )
2017
39
Characterization of Sarcoptes scabiei Tropomyosin and Paramyosin: Immunoreactive Allergens in Scabies. ( 28722633 )
2017
40
Crusted scabies due to indiscriminate use of glucocorticoid therapy in infant. ( 29186253 )
2017
41
The global burden of scabies: a cross-sectional analysis from the Global Burden of Disease Study 2015. ( 28941561 )
2017
42
Increased risk of pernicious anemia following scabies: a nationwide population-based matched-cohort study. ( 29066901 )
2017
43
Scabies-An ancient itch that is still rampant today. ( 28948630 )
2017
44
Crusted Scabies. ( 28767353 )
2017
45
An endemic of scabies in Kahuta, Azad Kashmir. The study shows a lack of awareness of scabies; mass treatment is needed. ( 28924288 )
2017
46
Mitochondrial genome sequencing reveals potential origins of the scabies mite Sarcoptes scabiei infesting two iconic Australian marsupials. ( 29183283 )
2017
47
Scabies. ( 28879092 )
2017
48
Scabies, Periorbital Cellulitis and Recurrent Skin Abscesses due to Panton-Valentine Leukocidin Positive S. aureus Mimic Hyper IgE Syndrome in an Infant. ( 28938255 )
2017
49
Contribution of the I^-glucosidase BglC to the onset of the pathogenic lifestyle of Streptomyces scabies. ( 29077242 )
2017
50
Scabies in the age of increasing drug resistance. ( 29190303 )
2017
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Variations for Scabies

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Expression for Scabies

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Search GEO for disease gene expression data for Scabies.
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Pathways for Scabies

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Pathways related to Scabies according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.54 CCL11 CFP CXCL8 IL10 IL1A KITLG
2
TGF-Beta Pathway 64
Show member pathways
 13.13 CCL11 CXCL8 IL10 IL1A KITLG
3
Akt Signaling 64
Show member pathways
 13 CCL11 CXCL8 IL10 IL1A KITLG
4
Cytokine Signaling in Immune system 66
Show member pathways
 12.94 CCL11 CXCL8 IL10 IL1A KITLG
5
PAK Pathway 64
Show member pathways
 12.78 CCL11 CXCL8 IL10 IL1A KITLG
6
Allograft rejection 1 37
Show member pathways
 12.52 CCL11 CXCL8 IL10 IL1A
7
Regulation of IFNA signaling 66
Show member pathways
 12.31 CXCL8 IL10 IL1A
8
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.76 CXCL8 IL10 IL1A
9
IL4-mediated signaling events 1
11.4 CCL11 IL10
10
Lung fibrosis 1
11.4 CCL11 CXCL8
11
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.39 CXCL8 IL1A
12
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.37 CCL11 CXCL8 IL10 IL1A KITLG
13
Staphylococcus aureus infection 37
11.33 IL10 MBL2
14
Pertussis 37
11.31 CXCL8 IL10 IL1A
15
Malaria 37
11.27 CXCL8 IL10
16
Hematopoietic Stem Cell Differentiation 1
11.25 IL1A KITLG
17
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 1
11.23 CCL11 CXCL8
18
Th2 Differentiation Pathway 65
11.21 CCL11 IL10
19
IL-10 Pathway 64
11.07 IL10 IL1A
20
Interleukin-10 signaling 66
11.02 CXCL8 IL10 IL1A
21
Cytokines and Inflammatory Response 1
10.99 IL10 IL1A
22
Interleukin-4 and 13 signaling 66
10.98 CCL11 CXCL8 IL10 IL1A
Sources

GO Terms for Scabies

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Cellular components related to Scabies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 CFP CXCL8 IL10 IL1A KITLG
2 extracellular space GO:0005615 9.17 CCL11 CFP CXCL8 IL10 IL1A KITLG

Biological processes related to Scabies according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.65 CFP IL10 MBL2
2 inflammatory response GO:0006954 9.62 CCL11 CXCL8 IL10 IL1A
3 positive regulation of angiogenesis GO:0045766 9.61 CCL11 CXCL8 IL1A
4 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.49 IL1A KITLG
5 positive regulation of cytokine secretion GO:0050715 9.46 IL10 IL1A
6 cytokine-mediated signaling pathway GO:0019221 9.46 CCL11 CXCL8 IL10 IL1A
7 negative regulation of growth of symbiont in host GO:0044130 9.4 IL10 MBL2
8 response to molecule of bacterial origin GO:0002237 9.37 CXCL8 IL10
9 immune response GO:0006955 9.35 CCL11 CFP CXCL8 IL10 IL1A
10 ectopic germ cell programmed cell death GO:0035234 9.26 IL1A KITLG
11 regulation of signaling receptor activity GO:0010469 9.02 CCL11 CXCL8 IL10 IL1A KITLG

Molecular functions related to Scabies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL11 CXCL8 IL10 IL1A KITLG
2 chemokine activity GO:0008009 8.96 CCL11 CXCL8
Sources

Sources for Scabies

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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