Scabies disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MedlinePlus: ⁴¹ Scabies is an itchy skin condition caused by the microscopic mite Sarcoptes scabei. It is common all over the world, and can affect anyone. Scabies spreads quickly in crowded conditions where there is frequent skin-to-skin contact between people. Hospitals, child-care centers, and nursing homes are examples. Scabies can easily infect sex partners and other household members. Sharing clothes, towels, and bedding can sometimes spread scabies. This can happen much more easily when the infested person has crusted scabies. You cannot get scabies from a pet. Pets get a different mite infection called mange. Symptoms are: Pimple-like irritations or a rash Intense itching, especially at night Sores caused by scratching Your health care provider diagnoses scabies by looking at the skin rash and finding burrows in the skin. Several lotions are available to treat scabies. The infected person's clothes, bedding and towels should be washed in hot water and dried in a hot dryer. Treatment is also recommended for household members and sexual partners. Centers for Disease Control and Prevention

MalaCards based summary: Scabies, also known as sarcoptic itch, is related to norwegian scabies and exanthem, and has symptoms including fever, pruritus and exanthema. An important gene associated with Scabies is MBL2 (Mannose Binding Lectin 2), and among its related pathways/superpathways are Innate Immune System and PAK Pathway. The drugs Azithromycin and Ivermectin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and liver, and related phenotype is immune system.

CDC: ² Scabies is an infestation of the skin by the human itch mite (Sarcoptes scabiei var. hominis). The microscopic scabies mite burrows into the upper layer of the skin where it lives and lays its eggs. The most common symptoms of scabies are intense itching and a pimple-like skin rash. The scabies mite usually is spread by direct, prolonged, skin-to-skin contact with a person who has scabies. Scabies is found worldwide and affects people of all races and social classes. Scabies can spread rapidly under crowded conditions where close body and skin contact is frequent. Institutions such as nursing homes, extended-care facilities, and prisons are often sites of scabies outbreaks. Child-care facilities also are a common site of scabies infestations.

Disease Ontology: ¹¹ A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

Wikipedia: ⁷⁵ Scabies (/ˈskeɪbiːz, ˈskeɪbiiːz/; also known as the seven-year itch) is a contagious skin infestation by... more...

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Related Diseases for Scabies

Diseases related to Scabies via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 677)

#	Related Disease	Score	Top Affiliating Genes
1	norwegian scabies	32.3	IL5 IL13 CD8A CD4 AADACL3
2	exanthem	30.4	IL4 CD8A CD4 CCR6
3	langerhans cell histiocytosis	30.3	TNFRSF8 CD1E CCR6
4	adult t-cell leukemia/lymphoma	30.2	TNFRSF8 CD8A CD4 CCR6
5	tinea corporis	30.2	FLG CD4
6	mastocytosis, cutaneous	30.2	TNFRSF8 IL31 CD1E
7	histiocytosis	30.2	TNFRSF8 IL4 CCR6
8	syphilis	30.1	CD8A CD4 CCR6
9	epidermolysis bullosa	30.1	FLG DST COL17A1
10	bullous pemphigoid	30.1	IL5 IL4 DST COL17A1
11	cellulitis	30.0	IL5 CD8A CD4 CCR6
12	thrombocytopenia due to platelet alloimmunization	30.0	CD8A CD4 CCR6
13	thrombocytopenic purpura, autoimmune	30.0	CD8A CD4 CCR6
14	granuloma annulare	30.0	CD8A CD4 CD1E
15	giardiasis	30.0	STH CD8A CD4
16	t-cell acute lymphoblastic leukemia	29.9	TNFRSF8 IL5 CD8A CD4 CCR6
17	occupational dermatitis	29.9	IL31 FLG
18	bacterial vaginosis	29.9	MBL2 CD4 CCR6
19	dermatitis herpetiformis	29.9	IL5 IL4 IL31
20	pneumocystosis	29.9	CD8A CD4 CCR6
21	onchocerciasis	29.9	STH IL5 IL4 IL13
22	epidermolysis bullosa dystrophica	29.9	FLG DST COL17A1
23	seborrheic dermatitis	29.9	FLG CD4 CD1E CCR6
24	spinal cord disease	29.8	CD8A CD4 CCR6
25	dermatitis	29.8	IL5 IL4 IL31 IL13 FLG CCR6
26	histiocytoid hemangioma	29.8	TNFRSF8 IL5
27	ige responsiveness, atopic	29.8	IL5 IL4 IL13
28	urticaria	29.8	IL5 IL4 IL31 IL13 CD4
29	candidiasis	29.7	MBL2 IL5 IL4
30	filariasis	29.7	STH IL5 IL4 IL13 CD4
31	pityriasis rosea	29.7	CD8A CD4 CD1E
32	genital herpes	29.7	CD8A CD4 CCR6
33	bacterial sepsis	29.7	CD8A CD4 CCR6
34	epidermolysis bullosa simplex	29.6	FLG DST COL17A1
35	immunoglobulin alpha deficiency	29.6	MBL2 CD8A CD4 CCR6
36	pemphigoid	29.6	IL5 IL4 IL31 IL13 DST COL17A1
37	pemphigus	29.5	IL4 DST COL17A1
38	lepromatous leprosy	29.5	IL4 CD8A CD4 CCR6
39	pemphigus vulgaris, familial	29.5	DST COL17A1 CCR6
40	granulomatous dermatitis	29.5	CD8A CD4 CD1E
41	trachoma	29.5	STH MBL2 IL4
42	chickenpox	29.4	IL4 CD8A CD4 CCR6
43	herpes zoster	29.4	COL17A1 CD8A CD4 CCR6
44	t-cell adult acute lymphocytic leukemia	29.4	TNFRSF8 CD8A CD4 CCR6
45	mastocytosis	29.4	TNFRSF8 IL4 IL13
46	lichen planus	29.3	IL4 FLG DST COL17A1
47	filarial elephantiasis	29.3	STH IL5 IL4 IL13 CD8A CD4
48	aspergillosis	29.3	MBL2 IL5 IL4 CCR6
49	leishmaniasis	29.3	IL5 IL4 IL13
50	autoimmune disease	29.3	MBL2 IL5 IL4 IL13 COL17A1 CCR6

Comorbidity relations with Scabies via Phenotypic Disease Network (PDN):

Acute Cystitis	Alzheimer Disease, Familial, 1
Decubitus Ulcer	Deficiency Anemia
Heart Disease	Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Scabies:

Sources

Symptoms & Phenotypes for Scabies

UMLS symptoms related to Scabies:

fever; pruritus; exanthema

MGI Mouse Phenotypes related to Scabies:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.36	CCR6 CD4 CD8A CFP COL17A1 DST

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Drugs & Therapeutics for Scabies

Drugs for Scabies (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Azithromycin

Approved

Phase 4

83905-01-5

447043

2

Ivermectin

Approved, Investigational, Vet_approved

Phase 4

70288-86-7

9812710 6427057

3

Anti-Bacterial Agents

Phase 4

4

Anti-Infective Agents

Phase 4

5

Antiparasitic Agents

Phase 4

6

Albendazole

Approved, Vet_approved

Phase 3

54965-21-8

2082

7

Diethylcarbamazine

Approved, Investigational, Vet_approved

Phase 3

90-89-1

3052

8

Malathion

Approved, Investigational

Phase 3

121-75-5

4004

9

Permethrin

Approved, Investigational

Phase 3

52645-53-1

40326

10

Artenimol

Approved, Experimental, Investigational

Phase 3

71939-50-9

540327

11

Piperaquine

Approved, Experimental, Investigational

Phase 3

4085-31-8

12

Anthelmintics

Phase 3

13

Neurotransmitter Agents

Phase 3

14

Cholinesterase Inhibitors

Phase 3

15

Cholinergic Agents

Phase 3

16

Antimitotic Agents

Phase 3

17

Tubulin Modulators

Phase 3

18

Emollients

Phase 3

19

Antiprotozoal Agents

Phase 3

20

Antimalarials

Phase 3

21

Benzocaine

Approved, Investigational

Phase 2

1994-09-7, 94-09-7

2337

22

Tannic acid

Approved

Phase 2

1401-55-4

16129878 16129778

23

Moxidectin

Approved, Investigational, Vet_approved

Phase 2

113507-06-5

72728820

24

Fennel

Approved, Experimental

Phase 2

25

English Lavender

Phase 2

26

Liver Extracts

27

Vaccines

Interventional clinical trials:

(show all 33)

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomized Controlled Trial Comparing the Effectiveness of Individual vs. Household Treatment for Scabies in Lambaréné, Gabon	Completed	NCT04205669	Phase 4	Benzyl Benzoate 25% Topical Application Lotion
2	Impact of Combined Azithromycin and Ivermectin Mass Drug Administration for Yaws and Scabies - Impact on Impetigo and Skin Microbiology	Completed	NCT02775617	Phase 4	Ivermectin;Azithromycin;Permethrin
3	A Single Treatment Pharmacokinetic and Safety Study of Natroba (Spinosad) Topical Suspension 0.9% w/w in Subjects 1 Month to 3 Years 11 Months of Age With an Active Scabies Infestation	Recruiting	NCT05310734	Phase 4	Spinosad Topical
4	Ivermectin Therapy for Scabies Infection in Children Younger Than 5 Years of Age (ITCHY Study)	Not yet recruiting	NCT05500326	Phase 4	Ivermectin Tablets
5	Oral Ivermectin Versus Topical Permethrin to Treat Scabies in Children: a Cluster Multicenter Randomized Trial	Unknown status	NCT02407782	Phase 3	Ivermectin;Permethrin
6	A Multi-center, Double-blind, Randomized, Parallel-group Study Comparing Permethrin Cream, 5% With Elimite™ in Patients With Active Scabies.	Completed	NCT02978508	Phase 3	Permethrin Cream, 5%;Elimite
7	A Randomized, Double-Blind, Parallel-Design, Multiple-Site Study to Evaluate the Therapeutic Equivalence of Permethrin Cream, 5% to Elimite™ Cream 5% in the Treatment of Scabies	Completed	NCT02572986	Phase 3	Permethrin
8	A Phase 3, Randomized, Double Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of Natroba™ (Spinosad) for the Treatment of Scabies	Completed	NCT02485704	Phase 3	spinosad topical suspension, 0.9%
9	A Randomized, Double-Blind, Parallel-Design, Multiple-Site Study to Evaluate the Therapeutic Equivalence of Permethrin Cream, 5% (Encube Ethicals) Compared to Elimite™ Cream (Permethrin) 5% (Prestium Pharma, Inc.) in the Treatment of Scabies	Completed	NCT03178942	Phase 3	Permethrin Cream, 5%;Elimite™ Cream (permethrin) 5%
10	A Phase 3, Randomized, Double Blind, Placebo-Controlled Study to Assess the Safety, Efficacy and Pharmacokinetics of Natroba™ (Spinosad) for the Treatment of Scabies	Completed	NCT02485717	Phase 3	spinosad topical suspension, 0.9%
11	Impact of Community Scabies Treatment on Head Lice Prevalence in the Solomon Islands	Completed	NCT03236168	Phase 3	Ivermectin;Permethrin 5%;Malathion Shampoo 0.5%
12	A Double Blind, Two Arm, Multicenter, Randomized, Parallel Group, Bioequivalence Study With Clinical Endpoints to Evaluate the Safety and Therapeutic Equivalence of Permethrin Cream 5% & Elimite™ in Subjects With Scabies	Completed	NCT03973775	Phase 3	Permethrin Cream 5%
13	A Cluster Randomised Trial of the Safety of Co-Administration of IDA (Ivermectin, Diethylcarbamazine and Albendazole) & Azithromycin for Integrated Treatment of Neglected Tropical Diseases	Completed	NCT03676140	Phase 3	Albendazole on Day 1;Ivermectin on Day 1;Diethylcarbamazine on day 1;Azithromycin on Day 1;Azithromycin on Day 8
14	Prospective, Open-label, Multicenter, Initially Single-armed and in Case of Treatment Failure Subsequently Three-armed Randomized Clinical Trial of Phase III/IV Investigating the Escalated Therapy of Scabies With INFECTOSCAB 5% (Permethrin)	Recruiting	NCT04814511	Phase 3	InfectoScab 5 % Creme;Permethrin 10 % Creme;Driponin 3 mg Tabletten
15	A Randomized Controlled Double-blind Trial Assessing the Efficacy of a 400µg/kg Ivermectin /5% Permethrin / Emollient Cream Regimen in Patients With Crusted Scabies as Compared to a 200µg/kg Ivermectin /5% Permethrin /Emollient Cream Regimen	Recruiting	NCT02841215	Phase 3	Ivermectin 200 µg/kg;Ivermectin 400 µg/kg
16	Adjunctive Ivermectin Mass Drug Administration for Malaria Control on the Bijagos Archipelago of Guinea Bissau: A Cluster-randomized Placebo-controlled Trial	Recruiting	NCT04844905	Phase 3	Ivermectin;Placebo;Dihydroartemisinin-piperaquine
17	A Phase II, Randomized, Double-blind, Parallel Group Dose Finding Study of Single Oral Doses of Moxidectin in Adults With Scabies	Completed	NCT03905265	Phase 2	Moxidectin Oral Product
18	A Randomised, Double Blind, Double Dummy Study to Compare the Efficacy and Safety of a Single Administration of Ivermectin to a Single Administration of Permethrin for the Treatment of Scabies	Completed	NCT00262418	Phase 2	Administration of ivermectin or permethrin
19	A Multicenter, Randomized, Double-Blind, Parallel Group Comparison Study of the Safety and Efficacy of Permethrin Foam, 5% Versus Permethrin Foam, 4% Versus Vehicle in Subjects With Sarcoptes Scabiei	Completed	NCT02094716	Phase 2	Permethrin Foam 4%;Permethrin Foam 5%;Vehicle Foam
20	A Randomised, Double-blind, Placebo-controlled Trial to Assess the Safety, Pharmacokinetics, and Efficacy of Escalating Doses of Oral Ivermectin in Scabies Infected Children Weighing 5 to Less Than 15 Kilograms	Not yet recruiting	NCT04332068	Phase 2	Oral ivermectin;Permethrin Cream
21	Comparative Study Between Topical Permethrin 5% and Oral Ivermectin for the Treatment of Scabies	Completed	NCT05362513	Phase 1	Ivermectin Tablets;Permethrin Cream
22	The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) - Part 4 -The Prevalence of Group A Streptococcal Pyoderma and Scabies in Infants in Fiji	Completed	NCT00436891
23	Veron Scabies Education and Eradication Program	Completed	NCT00604084		Ivermectin;Permethrin 5% lotion
24	Community Based Safety Study of 2-drug (Diethylcarbamazine and Albendazole) Versus 3-drug (Ivermectin, Diethylcarbamazine and Albendazole) Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji	Completed	NCT03177993		3 drug dose - IDA;3 drug dose - IDA with second dose of ivermectin;2 drug dose - DA
25	Better Disease Control by Multidrug Regimen in Scabies: A Randomized Controlled Trial	Completed	NCT05198947		Permethrin Lotion 5%;Permethrin Lotion 5% and Oral Ivermectin 200 mcg/kg
26	The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) Part 3: The Incidence of Group A Streptococcal Pharyngitis and the Prevalence of Pyoderma and Scabies in School Children in Fiji, and Establishing Immunologic Correlates of Protection for a J8 Vaccine	Completed	NCT00284882
27	The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) Part 1: The Prevalence of Rheumatic Heart Disease, Pyoderma and Scabies in School Children in Fiji	Completed	NCT00284843
28	East Arnhem Healthy Skin Project: A Regional Collaboration to Reduce Scabies, Skin Sores and Associated Chronic Diseases, Including Rheumatic Fever and Renal Disease, Among Australian Aboriginal Communities	Completed	NCT00884728
29	Efficacy and Side Effects of Blacksoap® as Adjuvant Therapy of Scabies: a Single-blind Randomized Control Trial	Completed	NCT05025696
30	PCR (Polymerase Chain Reaction) Assay for Diagnosis of Sarcoptes Scabiei	Completed	NCT02254564
31	Streptococcus Pyogenes Carriage Acquisition, Persistence and Transmission Dynamics Within Households in The Gambia: a Longitudinal Cohort Study	Completed	NCT05117528
32	Risk Factors for Treatment Failure of Scabies in Autochthonous Populations of French Guiana (GUYAGALE)	Recruiting	NCT04931680
33	Place of Hygiene in Scabies's Treatment in Populations in Precarious Situations	Not yet recruiting	NCT05271968

Search NIH Clinical Center for Scabies

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

ANISE OIL/CORIANDER OIL/LEMON OIL/ORANGE OIL

crotamiton

Ivermectin

Lindane

Permethrin

Piperonyl Butoxide

Cochrane evidence based reviews: scabies

Sources

Genetic Tests for Scabies

Sources

Anatomical Context for Scabies

Organs/tissues related to Scabies:

MalaCards : Skin, Breast, Liver, Heart, Spinal Cord, Bone Marrow, Kidney

Sources

Publications for Scabies

Articles related to Scabies:

(show top 50) (show all 3977)

#	Title	Authors	PMID	Year
1	Adjunctive Agent for Treating Scabies: In vitro Killing Activity of Permethrin and Tea Tree Oil on Sarcoptes scabiei Collected from Patients ⁶² ⁴¹	Yurekli A	36444410	2022
2	Contagious Itch, Disgust and Empathy in a Family with Scabies and their Treating Medical Staff: An Exploratory Study. ⁶² ⁴¹	Sutter M...Mueller SM	36281810	2022
3	Ivermectin mass drug administration for onchocerciasis elimination: can it reduce the prevalence of scabies in Ethiopia? ⁶² ⁴¹	Amsalu T...Van Griensven J	36156500	2022
4	Tropical parasitic itch in returned travellers and immigrants from endemic areas. ⁶²	Ju T...Yosipovitch G	35793476	2022
5	[[Translated article]]Diagnosis and Clinical Characteristics of Scabies in a Tertiary Care Hospital During the SARS-CoV-2 Pandemic: A Descriptive Study. ⁶²	Aguado Vazquez A...Diaz Corpas T	36464010	2022
6	Proteomic analysis of Sarcoptes scabiei reveals that proteins differentially expressed between eggs and female adult stages are involved predominantly in genetic information processing, metabolism and/or host-parasite interactions. ⁶²	Wang T...Fischer K	36472966	2022
7	The genetic characteristics of Sarcoptes scabiei from Chinese serow (Capricornis milneedwardsii) and goral (Naemorhedus goral arnouxianus) compared with other mites from different hosts and geographic locations using ITS2 and cox1 sequences. ⁶²	Zhou M...Hou Z	36201043	2022
8	Reproductive Losses and Their Causes in Alpacas-A Survey-Based Study. ⁶²	Kapustka J...Budzynska M	36359154	2022
9	An updated and comprehensive review on the ethnomedicinal uses, phytochemistry, pharmacological activity and toxicological profile of Tinospora crispa (L.) Hook. f. & Thomson. ⁶²	Haque E...Haque MA	36345416	2022
10	Epidemic Scabies: New Treatment Challenges in an Ancient Disease. ⁶²	Lluch Galcera JJ...Boada Garcia A	36462668	2022
11	Erythrodermic scabies in an immunocompetent patient. ⁶²	Talty R...King BA	36262356	2022
12	The Data on Scabies Cases During COVID-19 Pandemic: A Two-Year Analysis From the Largest Portuguese Tertiary Teaching Hospital. ⁶²	Brazao C...Filipe P	36368575	2022
13	Diagnosis and management of pediatric scabies: Results from a survey on 317 Italian dermatologists. ⁶²	Bassi A...Piccolo V	36116769	2022
14	Effects of ivermectin mass drug administration for malaria vector control on ectoparasites and soil-transmitted helminths: a cluster randomized trial. ⁶²	Kositz C...Bradley J	36336245	2022
15	Health and illness in migrants and refugees arriving in Europe: analysis of the electronic Personal Health Record system. ⁶²	Zenner D...Wickramage K	35238944	2022
16	[Therapeutic peculiarities in diseases of the nipple skin]. ⁶²	Luu Thi TH...Wohlrab J	35925215	2022
17	Successful treatment of refractory crusted scabies. ⁶²	Nishizawa T...Arioka H	36357115	2022
18	Lessons to learn from the analysis of routine health data from Moria Refugee Camp on Lesvos, Greece. ⁶²	Hart PL...Harkensee C	36415082	2022
19	Isoxazolines for treating canine demodicosis, sarcoptic mange (scabies), and lice infestation. ⁶²	Defalque VE	36325416	2022
20	Line-field confocal optical coherence tomography for the diagnosis of nodular scabies mimicking breast cancer skin metastasis. ⁶²	Orsini C...Russo F	36250785	2022
21	Comparison of sulfur ointment and permethrin treatments in scabies. ⁶²	Ertugrul G...Aktas H	36193643	2022
22	A scabies outbreak in an inpatient rehabilitation setting. ⁶²	Xu T...Yassin MH	36244573	2022
23	Clinical Conundrums: Differentiating Monkeypox From Similarly Presenting Infections. ⁶²	Hussain A...Maxwell T	36348880	2022
24	Increased Scabies Incidence at the Beginning of the 21st Century: What Do Reports from Europe and the World Show? ⁶²	Azdajic MD...Lugovic-Mihic L	36295033	2022
25	Scabies revisited in the COVID-19 era. ⁶²	Trave I...Parodi A	35723910	2022
26	Comment on 'Unexpected consequences of SARS-CoV-2 pandemic: scabies infestation'. ⁶²	Martora F...Angelo R	35633116	2022
27	Effects of Sarcoptes scabiei Translationally Controlled Tumor Protein (TCTP) on Histamine Release and Degranulation of KU812 Cells. ⁶²	Xu Z...Yang G	36361656	2022
28	Structure-based in silico design and in vitro acaricidal activity assessment of Acacia nilotica and Psidium guajava extracts against Sarcoptes scabiei var. cuniculi. ⁶²	Khan A...Ben Said M	35972548	2022
29	How secured and safe is the sanitation and hygiene services in a maximum-security correctional facility in Southwest Nigeria: a descriptive cross-sectional study. ⁶²	Aluko OO...Afolabi OT	34313160	2022
30	The Efficacy and Biopharmaceutical Properties of a Fixed-Dose Combination of Disulfiram and Benzyl Benzoate. ⁶²	Lajarin-Reinares M...Fernandez-Campos F	36142878	2022
31	Dermoscopy of nodular scabies: An observational study. ⁶²	Errichetti E...Lallas A	36149630	2022
32	Scabies incidence and association with skin and soft tissue infection in Loyalty Islands Province, New Caledonia: A 15-year retrospective observational study using electronic health records. ⁶²	Ducrot YM...Bertolotti A	36067187	2022
33	European scabies challenge: what about permethrin-resistant mites? ⁶²	Mayer KE...Posch C	35470925	2022
34	Mazzotti reaction: Ivermectin-associated polyarthritis after delayed scabies treatment. Case report and review of the literature. ⁶²	Antonio JA...Coen M	34732299	2022
35	Decreases in scabies and lice cases among the pediatric and adult populations during COVID-19. ⁶²	Bonanno M...Sayed C	35860857	2022
36	Prescriptions for scabies are rapidly increasing in Spain: An ecological study with national prescription data, 2008-2021. ⁶²	Martinez-Garcia E...Garcia-Doval I	36151936	2022
37	Bullous Pemphigoid and Scabies: Is There an Association? ⁶²	Rozenblat M...Ziv M	36074509	2022
38	Comparison of topical benzyl benzoate vs. oral ivermectin in treating scabies: A randomized study. ⁶²	Meyersburg D...Bauer JW	36097258	2022
39	Norwegian Scabies in an Atopic Patient Under Dupilumab Treatment. ⁶²	Rodriguez-Lago L...Borrego L	35943363	2022
40	Spectrum of skin diseases in Maroon villages of the Maroni area, French Guiana. ⁶²	Valentin J...Blaizot R	35767188	2022
41	Patient Care and Treatment Strategies for Skin Diseases in Sub Saharan Africa: Role of Traditional and Western Medicines. ⁶²	Sharma A...Meenakshi DU	36121085	2022
42	Mass Drug Administration for the Control of Scabies: A Systematic Review and Meta-analysis. ⁶²	Lake SJ...Romani L	35088849	2022
43	Comparative genomics of Sarcoptes scabiei provide new insights into adaptation to permanent parasitism and within-host species divergence. ⁶²	Xu J...Yang G	36134513	2022
44	Prevalence and burden of skin diseases among the elderly in Singapore: a 15-year clinical cohort study. ⁶²	Yew YW...Tan SH	35535625	2022
45	Disseminated scabies in a 2-month-old infant. ⁶²	Rasti S...Abdoli A	36110337	2022
46	Spinosad topical suspension (0.9%): a new topical treatment for scabies. ⁶²	Fernando DD...Fischer K	35799317	2022
47	Can we increase the success of scabies treatment? The effect of removing tunnels from patients in the success of scabies treatment. ⁶²	Yurekli A...Botsali A	35808934	2022
48	Drug eruption-like scabies surrepticius: an uncommonly described variant of scabies appearing in a non-classic clinical presentation. ⁶²	Cohen PR	36259867	2022
49	The national burden of scabies in Germany: a population-based approach using Internet search engine data. ⁶²	Wu J...Zink A	35133608	2022
50	High prevalence of scabies in Auckland pre-schools. ⁶²	Thornley S...McCarthy J	35999795	2022

Sources

Genes for Scabies

Genes related to Scabies (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MBL2	Mannose Binding Lectin 2	Protein Coding	10.84	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	CFP	Complement Factor Properdin	Protein Coding	10.16	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	CYP20A1	Cytochrome P450 Family 20 Subfamily A Member 1	Protein Coding	7.36	GeneCards inferred via : Publications (show sections)
4	GSTM1	Glutathione S-Transferase Mu 1	Protein Coding	7.36	GeneCards inferred via : Publications (show sections)
5	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	6.6	DISEASES inferred ¹⁴ ¹⁴
6	AADACL3	Arylacetamide Deacetylase Like 3	Protein Coding	6.12	DISEASES inferred ¹⁴
7	IL31	Interleukin 31	Protein Coding	6.03	DISEASES inferred ¹⁴
8	CD4	CD4 Molecule	Protein Coding	5.8	DISEASES inferred ¹⁴
9	STH	Saitohin	Protein Coding	5.5	DISEASES inferred ¹⁴
10	IL5	Interleukin 5	Protein Coding	5.48	DISEASES inferred ¹⁴
11	COL17A1	Collagen Type XVII Alpha 1 Chain	Protein Coding	5.45	DISEASES inferred ¹⁴
12	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	5.44	DISEASES inferred ¹⁴
13	FLG	Filaggrin	Protein Coding	5.39	DISEASES inferred ¹⁴
14	IL13	Interleukin 13	Protein Coding	5.36	DISEASES inferred ¹⁴
15	CD1E	CD1e Molecule	Protein Coding	5.19	DISEASES inferred ¹⁴
16	DST	Dystonin	Protein Coding	5.19	DISEASES inferred ¹⁴
17	IL4	Interleukin 4	Protein Coding	5.17	DISEASES inferred ¹⁴
18	CD8A	CD8a Molecule	Protein Coding	5.17	DISEASES inferred ¹⁴

Sources

Variations for Scabies

Sources

Expression for Scabies

Search GEO for disease gene expression data for Scabies.

Sources

Pathways for Scabies

Pathways related to Scabies according to GeneCards Suite gene sharing:

(show all 17)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.75	CCR6 CD4 CD8A CFP COL17A1 IL13
2	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.11	TNFRSF8 IL5 IL4 IL13 CD4 CCR6
3	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	11.96	IL5 IL4 CD8A CD4
4	IL12-mediated signaling events ⁶¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.78	IL4 CD8A CD4
5	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.77	IL5 IL4 CD8A CD4
6	Allograft rejection ⁷⁴	11.68	IL5 IL4 IL13
7	Glucocorticoid receptor regulatory network ⁶¹	11.59	IL5 IL4 IL13
8	Lung fibrosis ⁷⁴	11.49	IL5 IL4 IL13
9	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.44	IL5 IL4 IL13
10	Development and heterogeneity of the ILC family ⁷⁴	11.11	IL5 IL4 IL13
11	Th2 Differentiation ⁶⁵	11.02	IL5 IL4 IL31 IL13 CD4
12	Innate Lymphoid Cells Differentiation ⁶⁵	11	IL5 IL4 IL13 CD8A CD4 CCR6
13	Immune infiltration in pancreatic cancer ⁷⁴	10.98	IL5 IL4 IL13
14	Cytokines and inflammatory response ⁷⁴	10.92	IL5 IL4 IL13 CD4
15	OX40 Pathway ⁶⁴	10.91	IL5 IL4 IL13
16	Selective expression of chemokine receptors during T-cell polarization ⁷⁴	10.72	IL4 CD4
17	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.51	IL5 IL4 IL13

Sources

GO Terms for Scabies

Cellular components related to Scabies according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	9.4	MBL2 IL13 CD8A CD4 CD1E CCR6
2	hemidesmosome	GO:0030056	9.26	DST COL17A1

Biological processes related to Scabies according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	T cell activation	GO:0042110	9.85	IL4 CD8A CD4
2	positive regulation of B cell proliferation	GO:0030890	9.73	IL5 IL4 IL13
3	immune system process	GO:0002376	9.7	CD1E CD4 CD8A CFP IL31 MBL2
4	hemidesmosome assembly	GO:0031581	9.62	DST COL17A1
5	immune response	GO:0006955	9.53	IL5 IL4 IL13 CFP CD8A CD4
6	negative regulation of complement-dependent cytotoxicity	GO:1903660	9.26	IL4 IL13

Molecular functions related to Scabies according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine receptor binding	GO:0005126	8.92	IL4 IL31 IL13

Sources

Sources for Scabies

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: SCB001 MIFTS: 50	Scabies Categories: Infectious diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

Scabies

Aliases & Classifications for Scabies

MalaCards integrated aliases for Scabies:

Classifications:

External Ids:

Summaries for Scabies

Related Diseases for Scabies

Diseases related to Scabies via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Scabies via Phenotypic Disease Network (PDN):

Graphical network of the top 20 diseases related to Scabies:

Symptoms & Phenotypes for Scabies

UMLS symptoms related to Scabies:

MGI Mouse Phenotypes related to Scabies:

Drugs & Therapeutics for Scabies

Drugs for Scabies (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: scabies

Genetic Tests for Scabies

Anatomical Context for Scabies

Organs/tissues related to Scabies:

Publications for Scabies

Articles related to Scabies:

Genes for Scabies

Genes related to Scabies (0 elite genes):

Variations for Scabies

Expression for Scabies

Pathways for Scabies

Pathways related to Scabies according to GeneCards Suite gene sharing:

GO Terms for Scabies

Cellular components related to Scabies according to GeneCards Suite gene sharing:

Biological processes related to Scabies according to GeneCards Suite gene sharing:

Molecular functions related to Scabies according to GeneCards Suite gene sharing:

Sources for Scabies

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :