Aliases & Classifications for Scar Contracture

MalaCards integrated aliases for Scar Contracture:

Name: Scar Contracture 38

Summaries for Scar Contracture

MalaCards based summary : Scar Contracture is related to burns and burn scar. An important gene associated with Scar Contracture is ACTA2 (Actin, Alpha 2, Smooth Muscle, Aorta), and among its related pathways/superpathways are Akt Signaling and ICos-ICosL Pathway in T-Helper Cell. The drug Pharmaceutical Solutions has been mentioned in the context of this disorder. Affiliated tissues include skin, lung and smooth muscle, and related phenotype is muscle.

Related Diseases for Scar Contracture

Diseases related to Scar Contracture via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 burns 10.6
2 burn scar 10.6
3 hypertrophic scars 10.2
4 keloids 10.0
5 cervicitis 10.0
6 scoliosis 9.9
7 peyronie's disease 9.8
8 mucositis 9.8
9 laryngitis 9.8
10 depression 9.8

Graphical network of the top 20 diseases related to Scar Contracture:



Diseases related to Scar Contracture

Symptoms & Phenotypes for Scar Contracture

MGI Mouse Phenotypes related to Scar Contracture:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.8 ACTA2 ILK NFKB1

Drugs & Therapeutics for Scar Contracture

Drugs for Scar Contracture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Silicone Gel to Improve Scar in Microtia Patients Recruiting NCT02518035 Phase 4 Silicone Gel
2 Use of Pressure Garments for Burn Scars Withdrawn NCT00675974 Phase 2, Phase 3
3 Perforator Based Interposition Plasty Completed NCT01409759 Phase 2
4 A Clinical Study of Allogeneic Human Dermal Fibroblasts for Remodeling Scar Contractures Terminated NCT01564407 Phase 1, Phase 2 ICX‐RHY‐013
5 Clinical Evaluation of PoreSkin Completed NCT02486874 Phase 1
6 The Relationship of Rehabilitation Therapy Time To The Prevention of Burn Scar Contracture Completed NCT01161810
7 Fractionated Carbon Dioxide Laser and Burn Scar Contractures: Evaluation of Post-Treatment Scar Function and Appearance Completed NCT02115646 Not Applicable

Search NIH Clinical Center for Scar Contracture

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Scar Contracture cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Scar Contracture:
VAVELTA
Embryonic/Adult Cultured Cells Related to Scar Contracture:
Human Dermal Fibroblasts PMIDs: 20722660

Genetic Tests for Scar Contracture

Anatomical Context for Scar Contracture

MalaCards organs/tissues related to Scar Contracture:

41
Skin, Lung, Smooth Muscle, Bone

Publications for Scar Contracture

Articles related to Scar Contracture:

(show top 50) (show all 119)
# Title Authors Year
1
Reconstruction of Anterior Neck Scar Contracture Using A Perforator-Supercharged Transposition Flap. ( 29616160 )
2018
2
Use of autologous fat grafting for the correction of burn scar contracture in the hand: a case report. ( 28971111 )
2017
3
Deep Inferior Epigastric Perforator Free Flaps for Use in Complicated Groin Wound Repair: A Case Report of Severe Groin Scar Contracture and Review of Pedicled and Free Flaps in Groin Wound Repair. ( 28867912 )
2017
4
Perforator-based flaps for the treatment of burn scar contractures: a review. ( 28261622 )
2017
5
Perforator-Based Interposition Flaps Perform Better Than Full-Thickness Grafts for the Release of Burn Scar Contractures: A Multicenter Randomized Controlled Trial. ( 28121892 )
2017
6
The neck burn scar contracture: a concept of effective treatment. ( 28717655 )
2017
7
Current progress in understanding the molecular pathogenesis of burn scar contracture. ( 28546987 )
2017
8
A Band-Like Neck Scar Contracture after Bilateral Axillo-Breast Approach Robotic Thyroidectomy. ( 27896202 )
2016
9
The Lateral Position Improved Airway Patency in Anesthetized Patient With Burn-Induced Cervico-Mento-Sternal Scar Contracture. ( 27252906 )
2016
10
Profile of Patients Without Burn Scar Contracture Development. ( 27505046 )
2016
11
Development of International Outcomes Instrument for Hand and Upper Extremity Burn Scar Contracture Release. ( 27532614 )
2016
12
The Stanford-ReSurge Burn Scar Contracture Scale for Neck: Development and Initial Validation for Burn Scar Contracture. ( 27783006 )
2016
13
Hypertrophic scar contracture is mediated by the TRPC3 mechanical force transducer via NFkB activation. ( 26108359 )
2015
14
Surgical treatment of severe or moderate axillary burn scar contracture with transverse island scapular flap and expanded transverse island scapular flap in adult and pediatric patients-A clinical experience of 15 cases. ( 25698549 )
2015
15
Non-ablative fractional resurfacing in the treatment of scar contracture. ( 26251257 )
2015
16
Expanded thoracoacromial artery perforator flap for reconstruction of full-perioral scar contracture. ( 25668108 )
2015
17
Pedicled fasciocutaneous flaps for correcting scar contracture in pediatric patients-a retrospective study of 22 cases. ( 26777888 )
2015
18
Repairing post burn scar contractures with a rare form of Z-plasty. ( 26033651 )
2015
19
Scar contracture of anterior tonsillar pillar leading to difficult intubation. ( 25886119 )
2014
20
Axillary Fistula and Scar Contracture due to Uncontrolled Chronic Infection after Trans-Axillary Augmentation Mammaplasty. ( 25276663 )
2014
21
Botulinum Toxin Type A Inhibits I+-Smooth Muscle Actin and Myosin II Expression in Fibroblasts Derived From Scar Contracture. ( 25144422 )
2014
22
A Novel Immune Competent Murine Hypertrophic Scar Contracture Model: A Tool to Elucidate Disease Mechanism and Develop New Therapies. ( 25327261 )
2014
23
Reconstruction of cervical scar contracture using axial thoracic flap based on the thoracic branch of the supraclavicular artery. ( 25003452 )
2014
24
Three-dimensional Reconstruction of Scar Contracture-bearing Axilla and Digital Webs Using the Square Flap Method. ( 25289342 )
2014
25
A Systematic Review on Burn Scar Contracture Treatment; Searching for Evidence. ( 25051521 )
2014
26
Changes in Burn Scar Contracture: Utilization of a Severity Scale and Predictor of Return to Duty for Service Members. ( 25501771 )
2014
27
Protocol of surgical indications for scar contracture release before childbirth: Women with severe abdominal scars after burn injuries. ( 25141290 )
2014
28
Abstract 34: a novel immune competent murine hypertrophic scar contracture model: a tool to elucidate disease mechanism and develop new therapies. ( 25942145 )
2014
29
Controlled collagen crosslinking process in tissue-engineered fibroblast sheets for preventing scar contracture on the surface of lungs. ( 22298460 )
2013
30
Chin projection creation in patients with facial and cervical burn scar contracture. ( 22995426 )
2013
31
Double combined Z-plasty for wide-scar contracture release. ( 23434195 )
2013
32
Shikani Optical Stylet-guided Intubation via the Intubating Laryngeal Airway in Patients With Scar Contracture of the Face and Neck. ( 24382219 )
2013
33
An implant-supported removable partial denture for a patient with post-inflammatory scar contracture caused by burn complications: a clinical report. ( 22439102 )
2012
34
A review on static splinting therapy to prevent burn scar contracture: do clinical and experimental data warrant its clinical application? ( 21831527 )
2012
35
Perforator-based interposition flaps for sustainable scar contracture release: a versatile, practical, and safe technique. ( 21460661 )
2011
36
Combined AlloDermAr and thin skin grafting for the treatment of postburn dyspigmented scar contracture of the upper extremity. ( 20627834 )
2011
37
Repair of oral mucosal defects using artificial dermis: factors related to postoperative scar contracture. ( 21147006 )
2011
38
Aesthetic and functional restoration of anterior neck scar contracture using a bipedicled expanded forehead flap. ( 21855220 )
2011
39
The use of noncellularized artificial dermis in the prevention of scar contracture and hypertrophy. ( 21793966 )
2011
40
Functional improvement after ablative fractional laser treatment of a scar contracture. ( 22024331 )
2011
41
Aesthetic "Gull-wing" type incision for minimising postoperative scar contracture in the chin bone graft procedure. ( 19589739 )
2010
42
Release within scar using the needle-scalpel for treatment of scar contracture of the neck. ( 20335845 )
2010
43
Methods and tools used for the measurement of burn scar contracture. ( 20859215 )
2010
44
Free medial thigh perforator flap for reconstruction of the dynamic and static complex burn scar contracture. ( 19819077 )
2010
45
Difficulties with running V-Y plasty in releasing burn scar contracture. ( 21038117 )
2010
46
A new approach to the antecubital scar contracture: rhomboid rotation flap. ( 20129834 )
2010
47
Identification of cutaneous functional units related to burn scar contracture development. ( 19506493 )
2009
48
Analysis of upper extremity motion in children after axillary burn scar contracture release. ( 19826266 )
2009
49
The post-burn elbow medial flexion scar contracture treatment with trapeze-flap plasty. ( 18848399 )
2009
50
A circumferential incision technique to release wide scar contracture. ( 17884745 )
2008

Variations for Scar Contracture

Expression for Scar Contracture

Search GEO for disease gene expression data for Scar Contracture.

Pathways for Scar Contracture

Pathways related to Scar Contracture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.69 ACTA2 ILK NFKB1
2
Show member pathways
11.7 ACTA2 NFKB1
3 11.5 ILK TRPC3
4 11.24 ACTA2 NFKB1
5
Show member pathways
10.61 ILK NFKB1
6 10.11 ILK NFKB1

GO Terms for Scar Contracture

Cellular components related to Scar Contracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lamellipodium GO:0030027 8.62 ACTA2 ILK

Biological processes related to Scar Contracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of canonical Wnt signaling pathway GO:0090263 8.62 ILK NFKB1

Sources for Scar Contracture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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