Aliases & Classifications for Scar Contracture

MalaCards integrated aliases for Scar Contracture:

Name: Scar Contracture 39

Summaries for Scar Contracture

MalaCards based summary : Scar Contracture is related to burn scar and burns. An important gene associated with Scar Contracture is ILK (Integrin Linked Kinase), and among its related pathways/superpathways are Akt Signaling and ICos-ICosL Pathway in T-Helper Cell. The drug Pharmaceutical Solutions has been mentioned in the context of this disorder. Affiliated tissues include skin, bone and smooth muscle.

Related Diseases for Scar Contracture

Diseases related to Scar Contracture via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 burn scar 10.8
2 burns 10.3
3 hypertrophic scars 10.1
4 keloids 10.0
5 scoliosis 10.0
6 peyronie's disease 9.9
7 loeys-dietz syndrome 3 9.6 ACTA2 ILK

Graphical network of the top 20 diseases related to Scar Contracture:



Diseases related to Scar Contracture

Symptoms & Phenotypes for Scar Contracture

Drugs & Therapeutics for Scar Contracture

Drugs for Scar Contracture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Silicone Gel to Improve Scar in Microtia Patients Unknown status NCT02518035 Phase 4 Silicone Gel
2 Use of Pressure Garments for Burn Scars Withdrawn NCT00675974 Phase 2, Phase 3
3 Perforator Based Interposition Plasty Completed NCT01409759 Phase 2
4 A Clinical Study of Allogeneic Human Dermal Fibroblasts for Remodeling Scar Contractures Terminated NCT01564407 Phase 1, Phase 2 ICX‐RHY‐013
5 Clinical Evaluation of PoreSkin Completed NCT02486874 Phase 1
6 The Relationship of Rehabilitation Therapy Time To The Prevention of Burn Scar Contracture Completed NCT01161810
7 Fractionated Carbon Dioxide Laser and Burn Scar Contractures: Evaluation of Post-Treatment Scar Function and Appearance Completed NCT02115646 Not Applicable

Search NIH Clinical Center for Scar Contracture

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Scar Contracture cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Scar Contracture:
VAVELTA�, a suspension of human dermal fibrolasts for skin disease
Embryonic/Adult Cultured Cells Related to Scar Contracture:
Human Dermal Fibroblasts PMIDs: 20722660

Genetic Tests for Scar Contracture

Anatomical Context for Scar Contracture

MalaCards organs/tissues related to Scar Contracture:

42
Skin, Bone, Smooth Muscle

Publications for Scar Contracture

Articles related to Scar Contracture:

(show top 50) (show all 99)
# Title Authors Year
1
Reconstruction of Anterior Neck Scar Contracture Using A Perforator-Supercharged Transposition Flap. ( 29616160 )
2018
2
Ten-year Follow-up After Treating Extended Burn Scar Contracture with an Autologous Cultured Dermal Substitute. ( 30276038 )
2018
3
Use of autologous fat grafting for the correction of burn scar contracture in the hand: a case report. ( 28971111 )
2017
4
Deep Inferior Epigastric Perforator Free Flaps for Use in Complicated Groin Wound Repair: A Case Report of Severe Groin Scar Contracture and Review of Pedicled and Free Flaps in Groin Wound Repair. ( 28867912 )
2017
5
The neck burn scar contracture: a concept of effective treatment. ( 28717655 )
2017
6
Current progress in understanding the molecular pathogenesis of burn scar contracture. ( 28546987 )
2017
7
A Band-Like Neck Scar Contracture after Bilateral Axillo-Breast Approach Robotic Thyroidectomy. ( 27896202 )
2016
8
The Lateral Position Improved Airway Patency in Anesthetized Patient With Burn-Induced Cervico-Mento-Sternal Scar Contracture. ( 27252906 )
2016
9
Profile of Patients Without Burn Scar Contracture Development. ( 27505046 )
2016
10
Development of International Outcomes Instrument for Hand and Upper Extremity Burn Scar Contracture Release. ( 27532614 )
2016
11
The Stanford-ReSurge Burn Scar Contracture Scale for Neck: Development and Initial Validation for Burn Scar Contracture. ( 27783006 )
2016
12
Hypertrophic scar contracture is mediated by the TRPC3 mechanical force transducer via NFkB activation. ( 26108359 )
2015
13
Surgical treatment of severe or moderate axillary burn scar contracture with transverse island scapular flap and expanded transverse island scapular flap in adult and pediatric patients-A clinical experience of 15 cases. ( 25698549 )
2015
14
Non-ablative fractional resurfacing in the treatment of scar contracture. ( 26251257 )
2015
15
Expanded thoracoacromial artery perforator flap for reconstruction of full-perioral scar contracture. ( 25668108 )
2015
16
Pedicled fasciocutaneous flaps for correcting scar contracture in pediatric patients-a retrospective study of 22 cases. ( 26777888 )
2015
17
Scar contracture of anterior tonsillar pillar leading to difficult intubation. ( 25886119 )
2014
18
Axillary Fistula and Scar Contracture due to Uncontrolled Chronic Infection after Trans-Axillary Augmentation Mammaplasty. ( 25276663 )
2014
19
Botulinum Toxin Type A Inhibits I+-Smooth Muscle Actin and Myosin II Expression in Fibroblasts Derived From Scar Contracture. ( 25144422 )
2014
20
A Novel Immune Competent Murine Hypertrophic Scar Contracture Model: A Tool to Elucidate Disease Mechanism and Develop New Therapies. ( 25327261 )
2014
21
Reconstruction of cervical scar contracture using axial thoracic flap based on the thoracic branch of the supraclavicular artery. ( 25003452 )
2014
22
Three-dimensional Reconstruction of Scar Contracture-bearing Axilla and Digital Webs Using the Square Flap Method. ( 25289342 )
2014
23
A Systematic Review on Burn Scar Contracture Treatment; Searching for Evidence. ( 25051521 )
2014
24
Changes in Burn Scar Contracture: Utilization of a Severity Scale and Predictor of Return to Duty for Service Members. ( 25501771 )
2014
25
Protocol of surgical indications for scar contracture release before childbirth: Women with severe abdominal scars after burn injuries. ( 25141290 )
2014
26
Abstract 34: a novel immune competent murine hypertrophic scar contracture model: a tool to elucidate disease mechanism and develop new therapies. ( 25942145 )
2014
27
Controlled collagen crosslinking process in tissue-engineered fibroblast sheets for preventing scar contracture on the surface of lungs. ( 22298460 )
2013
28
Chin projection creation in patients with facial and cervical burn scar contracture. ( 22995426 )
2013
29
Double combined Z-plasty for wide-scar contracture release. ( 23434195 )
2013
30
Shikani Optical Stylet-guided Intubation via the Intubating Laryngeal Airway in Patients With Scar Contracture of the Face and Neck. ( 24382219 )
2013
31
An implant-supported removable partial denture for a patient with post-inflammatory scar contracture caused by burn complications: a clinical report. ( 22439102 )
2012
32
A review on static splinting therapy to prevent burn scar contracture: do clinical and experimental data warrant its clinical application? ( 21831527 )
2012
33
Perforator-based interposition flaps for sustainable scar contracture release: a versatile, practical, and safe technique. ( 21460661 )
2011
34
Combined AlloDermAr and thin skin grafting for the treatment of postburn dyspigmented scar contracture of the upper extremity. ( 20627834 )
2011
35
Repair of oral mucosal defects using artificial dermis: factors related to postoperative scar contracture. ( 21147006 )
2011
36
Aesthetic and functional restoration of anterior neck scar contracture using a bipedicled expanded forehead flap. ( 21855220 )
2011
37
The use of noncellularized artificial dermis in the prevention of scar contracture and hypertrophy. ( 21793966 )
2011
38
Functional improvement after ablative fractional laser treatment of a scar contracture. ( 22024331 )
2011
39
Aesthetic "Gull-wing" type incision for minimising postoperative scar contracture in the chin bone graft procedure. ( 19589739 )
2010
40
Release within scar using the needle-scalpel for treatment of scar contracture of the neck. ( 20335845 )
2010
41
Methods and tools used for the measurement of burn scar contracture. ( 20859215 )
2010
42
Free medial thigh perforator flap for reconstruction of the dynamic and static complex burn scar contracture. ( 19819077 )
2010
43
Difficulties with running V-Y plasty in releasing burn scar contracture. ( 21038117 )
2010
44
A new approach to the antecubital scar contracture: rhomboid rotation flap. ( 20129834 )
2010
45
Identification of cutaneous functional units related to burn scar contracture development. ( 19506493 )
2009
46
Analysis of upper extremity motion in children after axillary burn scar contracture release. ( 19826266 )
2009
47
The post-burn elbow medial flexion scar contracture treatment with trapeze-flap plasty. ( 18848399 )
2009
48
A circumferential incision technique to release wide scar contracture. ( 17884745 )
2008
49
A case of neck scar contracture reconstructed using a pedicled supraclavicular flap. ( 18176264 )
2008
50
Clinical experience of airway management and tracheal intubation under general anesthesia in patients with scar contracture of the neck. ( 18706246 )
2008

Variations for Scar Contracture

Expression for Scar Contracture

Search GEO for disease gene expression data for Scar Contracture.

Pathways for Scar Contracture

GO Terms for Scar Contracture

Cellular components related to Scar Contracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lamellipodium GO:0030027 8.62 ACTA2 ILK

Biological processes related to Scar Contracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of canonical Wnt signaling pathway GO:0090263 8.96 ILK NFKB1
2 positive regulation of transcription, DNA-templated GO:0045893 8.8 ACTA2 ILK NFKB1

Sources for Scar Contracture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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