MCID: SCR015
MIFTS: 42

Scarlet Fever

Categories: Immune diseases, Infectious diseases, Oral diseases, Respiratory diseases

Aliases & Classifications for Scarlet Fever

MalaCards integrated aliases for Scarlet Fever:

Name: Scarlet Fever 12 76 55 3 44 15 63 73
Scarlatina 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8596
ICD10 33 A38 A38.9
ICD9CM 35 034 034.1
MeSH 44 D012541
NCIt 50 C94575
SNOMED-CT 68 30242009

Summaries for Scarlet Fever

PubMed Health : 63 About scarlet fever: Scarlet fever is a bacterial infection that mainly affects children. It usually causes a typical rash, fever and a sore throat.Thanks to antibiotics like penicillin, scarlet fever is easy to treat. Antibiotics can also reduce the time during which children with scarlet fever are contagious. The infection is spread through bacteria-containing droplets and close physical contact.Before the development of penicillin, scarlet fever sometimes led to serious complications. But it’s usually quite a mild illness nowadays. It’s still important to try to stop it from spreading to other people, though. One thing you can do is wash your hands often.Unlike with many other childhood diseases, having had scarlet fever in the past doesn't make you immune to future scarlet fever infections. So people can have it more than once in their lives.

MalaCards based summary : Scarlet Fever, also known as scarlatina, is related to staphylococcal scarlet fever and rheumatic fever. An important gene associated with Scarlet Fever is EDNRA (Endothelin Receptor Type A), and among its related pathways/superpathways are Endothelins and Endothelin Pathways. The drugs Amoxicillin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include lymph node, tongue and testes, and related phenotypes are muscle and vision/eye

Disease Ontology : 12 An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash.

CDC : 3 Bacteria called group A Streptococcus (group A strep) can cause many different infections. Some of these are common, relatively minor infections, like strep throat. Others are less common, but very serious and even deadly. People can easily spread group A strep to other people. Practicing good hygiene, like washing your hands often, is the best way to protect yourself from group A strep infections.

Wikipedia : 76 Scarlet fever is a disease which can occur as a result of a group A streptococcus (group A strep)... more...

Related Diseases for Scarlet Fever

Diseases related to Scarlet Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 staphylococcal scarlet fever 12.6
2 rheumatic fever 11.6
3 diphtheria 10.7
4 measles 10.6
5 rheumatic fever-related antigen 10.4
6 tonsillitis 10.4
7 purpura 10.3
8 otitis media 10.3
9 pharyngitis 10.3
10 hepatitis 10.3
11 mastoiditis 10.3
12 pertussis 10.3
13 toxic shock syndrome 10.3
14 erysipelas 10.2
15 cellulitis 10.2
16 rubella 10.2
17 glomerulonephritis 10.2
18 sinusitis 10.2
19 purpura fulminans 10.2
20 thrombosis 10.2
21 pericarditis 10.2
22 pneumonia 10.2
23 meningitis 10.2
24 bullous impetigo 10.1 EDNRA EDNRB
25 perinephritis 10.1 EDNRA EDNRB
26 exanthem 10.1
27 nasopharyngitis 10.1
28 hemiplegia 10.1
29 heart disease 10.1
30 hepatitis a 10.1
31 typhoid fever 10.1
32 laryngitis 10.1
33 myocarditis 10.1
34 chickenpox 10.1
35 psoriasis 10.1
36 streptococcal toxic-shock syndrome 10.1
37 radiation proctitis 10.1 EDNRA EDNRB
38 commensal bacterial infectious disease 10.0 EDNRB MYOM2
39 cystic kidney disease 10.0 EDNRA EDNRB
40 streptococcal meningitis 10.0 MYOM2 SPEG
41 relapsing fever 9.9
42 urticaria 9.9
43 suppurative lymphadenitis 9.9 HSF4 P3H2
44 pleural empyema 9.9 HSF4 P3H2
45 atrial standstill 1 9.9
46 thrombocytopenic purpura, autoimmune 9.9
47 asthma 9.9
48 kawasaki disease 9.9
49 rheumatic heart disease 9.9
50 breast abscess 9.9

Graphical network of the top 20 diseases related to Scarlet Fever:



Diseases related to Scarlet Fever

Symptoms & Phenotypes for Scarlet Fever

MGI Mouse Phenotypes related to Scarlet Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.26 EDNRA EDNRB HOXD13 SPEG
2 vision/eye MP:0005391 9.02 EDNRA EDNRB HOXD13 HSF4 P3H2

Drugs & Therapeutics for Scarlet Fever

PubMedHealth treatment related to Scarlet Fever: 63

Scarlet fever is treated with antibiotics – also because that means you will no longer be contagious after 24 hours. They make the symptoms go away a little faster and help to prevent possible complications too. The most commonly used antibiotics for the treatment of scarlet fever are penicillin-based. They are taken two or three times a day for ten days. If someone is allergic to penicillin or it is not well-tolerated, they can take other antibiotics. The possible side effects include nausea, diarrhea and a rash. It’s important to keep taking all the antibiotics even if your symptoms have already gone away. That’s the only way to make sure that all of the germs are killed.Symptoms like a sore throat or fever can be relieved by taking medicine such as ibuprofen or acetaminophen (paracetamol). Other things that may have a soothing effect include sucking throat lozenges, drinking tea or using home remedies such as neck wraps.

Drugs for Scarlet Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
2 Anti-Bacterial Agents Phase 4
3 Anti-Infective Agents Phase 4
4 Antibiotics, Antitubercular Phase 4
5 Immunoglobulins, Intravenous Phase 3
6 gamma-Globulins Phase 3
7 Immunoglobulins Phase 3
8 Immunologic Factors Phase 3
9 Rho(D) Immune Globulin Phase 3
10 Antibodies Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Group A Pharyngitis in Children: The GASPARD Study Recruiting NCT03264911 Phase 4 Amoxicillin or Placebo
2 Intravenous Immunoglobulin for PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections) Unknown status NCT01281969 Phase 3 Gamunex Intravenous Immunoglobulin;Placebo
3 Characterization of Childhood-Onset Obsessive-Compulsive Disorder Completed NCT00044239

Search NIH Clinical Center for Scarlet Fever

Cochrane evidence based reviews: scarlet fever

Genetic Tests for Scarlet Fever

Anatomical Context for Scarlet Fever

MalaCards organs/tissues related to Scarlet Fever:

41
Lymph Node, Tongue, Testes, Tonsil, Bone, Heart, Kidney

Publications for Scarlet Fever

Articles related to Scarlet Fever:

(show top 50) (show all 892)
# Title Authors Year
1
Constantly high incidence of scarlet fever in Germany. ( 29695362 )
2018
2
Increasing Number of Scarlet Fever Cases, South Korea, 2011-2016. ( 29260684 )
2018
3
Complete Genome Sequence of a Streptococcus pyogenes Serotype M12 Scarlet Fever Outbreak Isolate from China, Compiled Using Oxford Nanopore and Illumina Sequencing. ( 29724853 )
2018
4
Scarlet fever makes a comeback. ( 29191627 )
2018
5
Lichen striatus following scarlet fever in a 3-year-old female patient. ( 29655190 )
2018
6
Resurgence of scarlet fever in China: a 13-year population-based surveillance study. ( 29858148 )
2018
7
Resurgence of scarlet fever in England, 2014-16: a population-based surveillance study. ( 29191628 )
2018
8
Outbreak Investigation of Scarlet Fever in a Kindergarten. ( 29637758 )
2018
9
Impact of meteorological factors on scarlet fever in Jiangsu province, China. ( 29909092 )
2018
10
The resurgence of scarlet fever in China. ( 29858151 )
2018
11
Scarlet Fever Epidemic in China Caused by Streptococcus pyogenes Serotype M12: Epidemiologic and Molecular Analysis. ( 29342444 )
2018
12
Investigation of Scarlet Fever Outbreak in a Kindergarten. ( 29637751 )
2018
13
The Comeback of Scarlet Fever. ( 29396303 )
2018
14
Unusual case of suspected recurrent scarlet fever in a UK serviceman. ( 29653937 )
2018
15
Scarlet Fever ( 29939666 )
2018
16
Hypotheses for the resurgence of scarlet fever in China. ( 30152352 )
2018
17
A 12 year outbreak of scarlet fever in Singapore. ( 30152353 )
2018
18
Hypotheses for the resurgence of scarlet fever in China - Authors' reply. ( 30152354 )
2018
19
Managing scarlet fever. ( 30166279 )
2018
20
Effects of meteorological factors on incidence of scarlet fever during different periods in different districts of China. ( 28073056 )
2017
21
Incidence and Characteristics of Scarlet Fever, South Korea, 2008-2015. ( 28322696 )
2017
22
Epidemiology of Reemerging Scarlet Fever, Hong Kong, 2005-2015. ( 28930009 )
2017
23
Genome analysis following a national increase in Scarlet Fever in England 2014. ( 28283023 )
2017
24
Scarlet fever: a guide for general practitioners. ( 29081840 )
2017
25
Spatiotemporal epidemiology of scarlet fever in Jiangsu Province, China, 2005-2015. ( 28854889 )
2017
26
Scarlet Fever. ( 28514617 )
2017
27
Managing scarlet fever. ( 28882851 )
2017
28
Scarlet fever in Poland in 2014 ( 27779834 )
2016
29
Spatiotemporal Pattern Analysis of Scarlet Fever Incidence in Beijing, China, 2005-2014. ( 26784213 )
2016
30
Pharyngitis and Scarlet Fever ( 26866221 )
2016
31
Scarlet Fever Upsurge in England and Molecular-Genetic Analysis in North-West London, 2014. ( 27192393 )
2016
32
Impact of meteorological changes on the incidence of scarlet fever in Hefei City, China. ( 26932715 )
2016
33
Effect of administration of Streptococcus salivarius K12 on the occurrence of streptococcal pharyngo-tonsillitis, scarlet fever and acute otitis media in 3 years old children. ( 27874935 )
2016
34
Scarlet fever warning as number of cases jumps to highest level since the 1960s. ( 27156406 )
2016
35
Re-emergence of scarlet fever: old players return? ( 27249582 )
2016
36
Scarlet fever. ( 27191292 )
2016
37
Increasing prevalence of scarlet fever in China. ( 27188472 )
2016
38
The Association between Environmental Factors and Scarlet Fever Incidence in Beijing Region: Using GIS and Spatial Regression Models. ( 27827946 )
2016
39
Sixty seconds on . . . scarlet fever. ( 27009299 )
2016
40
Operation Pied Piper: a geographical reappraisal of the impact of wartime evacuation on scarlet fever and diphtheria rates in England and Wales, 1939-1945. ( 25703695 )
2015
41
Scarlet fever: A not so typical exanthematous pharyngotonsillitis (based on 171 cases). ( 26585817 )
2015
42
Scarlet fever in Poland in 2013. ( 26233076 )
2015
43
Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone. ( 26522788 )
2015
44
PHE issues scarlet fever guidance for schools. ( 24974543 )
2014
45
At a glance: scarlet fever in children. ( 24941729 )
2014
46
Scarlet Fever in an adult. ( 24429462 )
2014
47
Spectral analysis based on fast Fourier transformation (FFT) of surveillance data: the case of scarlet fever in China. ( 23746087 )
2014
48
Increase in scarlet fever notifications in the United Kingdom, 2013/2014. ( 24698137 )
2014
49
Scarlet fever in Poland in 2012. ( 25135501 )
2014
50
Scarlet fever. ( 24823566 )
2014

Variations for Scarlet Fever

Expression for Scarlet Fever

Search GEO for disease gene expression data for Scarlet Fever.

Pathways for Scarlet Fever

Pathways related to Scarlet Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.88 EDNRA EDNRB
2 10.49 EDNRA EDNRB
3 10.1 EDNRA EDNRB

GO Terms for Scarlet Fever

Biological processes related to Scarlet Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.26 EDNRA EDNRB
2 vasoconstriction GO:0042310 9.16 EDNRA EDNRB
3 enteric nervous system development GO:0048484 8.96 EDNRA EDNRB
4 endothelin receptor signaling pathway GO:0086100 8.62 EDNRA EDNRB

Molecular functions related to Scarlet Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endothelin receptor activity GO:0004962 8.62 EDNRA EDNRB

Sources for Scarlet Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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