MCID: SCR015
MIFTS: 38

Scarlet Fever

Categories: Immune diseases, Infectious diseases, Oral diseases, Respiratory diseases, Smell/Taste diseases

Aliases & Classifications for Scarlet Fever

MalaCards integrated aliases for Scarlet Fever:

Name: Scarlet Fever 12 73 54 44 15 62 17 70 32
Scarlatina 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8596
ICD9CM 34 034 034.1
MeSH 44 D012541
NCIt 50 C94575
SNOMED-CT 67 154301006 154303009
ICD10 32 A38
UMLS 70 C0036285 C0343487

Summaries for Scarlet Fever

PubMed Health : 62 About scarlet fever: Scarlet fever is a bacterial infection that mainly affects children. It usually causes a typical rash, fever and a sore throat. Thanks to antibiotics like penicillin, scarlet fever is easy to treat. Antibiotics can also reduce the time during which children with scarlet fever are contagious. The infection is spread through bacteria-containing droplets and close physical contact. Before the development of penicillin, scarlet fever sometimes led to serious complications. But it’s usually quite a mild illness nowadays. It’s still important to try to stop it from spreading to other people, though. One thing you can do is wash your hands often. Unlike with many other childhood diseases, having had scarlet fever in the past doesn't make you immune to future scarlet fever infections. So people can have it more than once in their lives.

MalaCards based summary : Scarlet Fever, also known as scarlatina, is related to rheumatic fever and mastoiditis. An important gene associated with Scarlet Fever is EDNRA (Endothelin Receptor Type A), and among its related pathways/superpathways is Overview of nanoparticle effects. Affiliated tissues include skin, tongue and t cells, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Disease Ontology : 12 An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash.

Wikipedia : 73 Scarlet fever is a disease resulting from a group A streptococcus (group A strep) infection, also known... more...

Related Diseases for Scarlet Fever

Diseases related to Scarlet Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 385)
# Related Disease Score Top Affiliating Genes
1 rheumatic fever 31.6 TNF MYOM2 ALB
2 mastoiditis 30.9 SPEG CRP
3 exanthem 30.7 TNF CRP ALB
4 impetigo 30.6 TST MYOM2 EDNRB EDNRA
5 streptococcal toxic-shock syndrome 30.4 TNF MYOM2
6 toxic shock syndrome 30.4 TNF MYOM2 EDNRA CRP
7 chickenpox 30.3 TNF CRP ALB
8 purpura 30.3 TNF CRP C3
9 erysipelas 30.3 TNF MYOM2 CRP
10 breast abscess 30.3 ETV5 CRP
11 pharyngitis 30.3 TNF SPEG MYOM2 ETV5 CRP
12 ritter's disease 30.3 TST EDNRB EDNRA
13 typhoid fever 30.2 TNF CRP ALB
14 pleural empyema 30.1 CRP ALB
15 laryngitis 30.0 TNF CRP
16 pericarditis 30.0 TNF CRP ALB
17 mastitis 30.0 TST EDNRA ALB
18 pustulosis of palm and sole 30.0 TNF CRP
19 cellulitis 30.0 TNF MYOM2 CRP ALB
20 tetanus 30.0 TNF CRP ALB
21 pyomyositis 30.0 TST MYOM2 EDNRB CRP
22 dysentery 30.0 TNF CRP ALB
23 otitis media 29.9 TNF CRP C3 ALB
24 endocarditis 29.9 TNF CRP ALB
25 diffuse glomerulonephritis 29.9 CFP C3
26 parotitis 29.9 CRP ALB
27 necrotizing fasciitis 29.8 TST SPEG MYOM2 ETV5 CRP ALB
28 syphilis 29.6 TNF CRP ALB
29 hemorrhoid 29.6 TNF CRP ALB
30 facial paralysis 29.6 TNF CRP ALB
31 appendicitis 29.6 TNF CRP ALB
32 peritonitis 29.6 TNF CRP ALB
33 gastroenteritis 29.6 TNF CRP ALB
34 relapsing fever 29.4 TNF CRP C3
35 kawasaki disease 29.4 TNF ITPKC CRP ALB
36 pulmonary tuberculosis 29.4 TNF C3 ALB
37 meningitis 29.3 TNF CRP CFP C3 ALB
38 streptococcus pneumonia 29.2 TNF CRP C3 ALB
39 heart disease 28.6 TNF MYOM2 EDNRB EDNRA CRP C3
40 staphylococcal scarlet fever 11.4
41 diphtheria 10.8
42 measles 10.7
43 tonsillitis 10.5
44 pertussis 10.5
45 rheumatic fever-related antigen 10.5
46 disease by infectious agent 10.5
47 pulmonary arterial hypertension associated with connective tissue disease 10.4 EDNRB EDNRA
48 bullous impetigo 10.4 EDNRB EDNRA
49 enthesopathy 10.4
50 acquired color blindness 10.4 EDNRB EDNRA

Graphical network of the top 20 diseases related to Scarlet Fever:



Diseases related to Scarlet Fever

Symptoms & Phenotypes for Scarlet Fever

MGI Mouse Phenotypes related to Scarlet Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 ALB B4GALNT2 C3 CFP CRP EDNRA
2 endocrine/exocrine gland MP:0005379 9.91 ALB C3 EDNRA EDNRB ETV5 HOXD13
3 immune system MP:0005387 9.9 ALB B4GALNT2 C3 CFP CRP EDNRA
4 digestive/alimentary MP:0005381 9.87 ALB B4GALNT2 C3 EDNRA EDNRB HOXD13
5 muscle MP:0005369 9.5 ALB C3 EDNRA EDNRB HOXD13 SPEG
6 renal/urinary system MP:0005367 9.17 ALB C3 EDNRA EDNRB ETV5 HOXD13

Drugs & Therapeutics for Scarlet Fever

PubMed Health treatment related to Scarlet Fever: 62

Scarlet fever is treated with antibiotics – also because that means you will no longer be contagious after 24 hours. They make the symptoms go away a little faster and help to prevent possible complications too. The most commonly used antibiotics for the treatment of scarlet fever are penicillin -based. They are taken two or three times a day for ten days. If someone is allergic to penicillin or it is not well-tolerated, they can take other antibiotics. The possible side effects include nausea , diarrhea and a rash . It’s important to keep taking all the antibiotics even if your symptoms have already gone away. That’s the only way to make sure that all of the germs are killed. Symptoms like a sore throat or fever can be relieved by taking medicine such as ibuprofen or acetaminophen (paracetamol). Other things that may have a soothing effect include sucking throat lozenges, drinking tea or using home remedies such as neck wraps.

Search Clinical Trials , NIH Clinical Center for Scarlet Fever

Cochrane evidence based reviews: scarlet fever

Genetic Tests for Scarlet Fever

Anatomical Context for Scarlet Fever

MalaCards organs/tissues related to Scarlet Fever:

40
Skin, Tongue, T Cells, Cortex, Adrenal Cortex, Kidney, Bone Marrow

Publications for Scarlet Fever

Articles related to Scarlet Fever:

(show top 50) (show all 2500)
# Title Authors PMID Year
1
[Streptococcal group A carriage: new data on the characteristics of the biology of the causative agent and of the immune response of the host]. 54 61
7856351 1994
2
Erythrogenic toxin type A (ETA): epidemiological analysis of gene distribution and protein formation in clinical Streptococcus pyogenes strains causing scarlet fever and the streptococcal toxic shock-like syndrome (TSLS). 61 54
8219499 1993
3
Use of meteorological parameters for forecasting scarlet fever morbidity in Tianjin, Northern China. 61
33026621 2021
4
Spatiotemporal clustering and meteorological factors affected scarlet fever incidence in mainland China from 2004 to 2017. 61
33684741 2021
5
Characterization of group A beta-haemolytic streptococcus with mucoid phenotype isolated in a tertiary hospital. 61
33593612 2021
6
Thoughts, beliefs and concepts concerning infectious childhood diseases of physicians practicing homeopathic, anthroposophic and conventional medicine - a qualitative study. 61
33499846 2021
7
Natural or intended mummification? Specific case of a child mummy. 61
33399626 2021
8
Mathematical modelling for scarlet fever with direct and indirect infections. 61
33063646 2020
9
Epidemiological analysis of Group A Streptococcus infections in a hospital in Beijing, China. 61
32676802 2020
10
Non-Pharmaceutical Interventions and Military Hygiene at the United States Military Academy between 1890 and 1910. 61
32870979 2020
11
Chronological changes in strawberry tongue in toxic shock syndrome toxin-1-mediated Exanthematous Disease. 61
33304729 2020
12
Impact of non-pharmaceutical interventions on the incidence of respiratory infections during the COVID-19 outbreak in Korea: a nationwide surveillance study. 61
33150393 2020
13
Scarlet Fever After Streptococcus pyogenes Skin Infection Associated With FreeStyle Libre Glucose Monitoring. 61
33582045 2020
14
Scarlet fever outbreak in a primary and middle school in Germany: importance of case ascertainment and risk communication. 61
33143786 2020
15
Out-of-season increase of puerperal fever with group A Streptococcus infection: a case-control study, Netherlands, July to August 2018. 61
33034283 2020
16
Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes. 61
33024089 2020
17
Scarlet fever - a diagnostic challenge for dentists and physicians: A report of 2 cases with diverse symptoms. 61
33448168 2020
18
Increase of emm1 isolates among group A Streptococcus strains causing scarlet fever in Shanghai, China. 61
32562850 2020
19
Severe scarlet fever in a child with Down syndrome - a case report. 61
33134206 2020
20
[Textual research on Xilei Powder]. 61
33164412 2020
21
Emergence of macrolide-resistant Streptococcus pyogenes emm12 in southern Taiwan from 2000 to 2019. 61
32994137 2020
22
Exposure to air pollution and scarlet fever resurgence in China: a six-year surveillance study. 61
32843631 2020
23
Changes in M types of Streptococcus pyogenes in Chinese children with scarlet fever. 61
32592668 2020
24
Using the MCRISP Network for Surveillance of Pediatric Exanthema in Child Care Centers. 61
32693853 2020
25
Molecular epidemiology and antimicrobial resistance of group a streptococcus recovered from patients in Beijing, China. 61
32660436 2020
26
Two females with coronary artery occlusion caused by presumed Kawasaki disease would have delivered without recognition of ischaemic heart disease. 61
32383412 2020
27
Paediatrics in Theresienstadt ghetto. 61
32592562 2020
28
Alexandroupolis (Dedeagatch): A city born of infections and the first documented death of the Italian civilian Giuseppe Bigheti. 61
32487795 2020
29
The association between ambient particulate matters, nitrogen dioxide, and childhood scarlet fever in Hangzhou, Eastern China, 2014-2018. 61
31918112 2020
30
[Epidemiological characteristics of scarlet fever in Hubei Province from 2009 to 2018]. 61
32388961 2020
31
Urbanization and mortality in Britain, c. 1800-50. 61
32355360 2020
32
Spatial-temporal analysis and visualization of scarlet fever in mainland China from 2004 to 2017. 61
32241094 2020
33
Infectious diseases in children and adolescents in China: analysis of national surveillance data from 2008 to 2017. 61
32241761 2020
34
Bacterial, viral, and fungal infection-related risk of Parkinson's disease: Meta-analysis of cohort and case-control studies. 61
32017453 2020
35
Notifiable Respiratory Infectious Diseases in China: A Spatial-Temporal Epidemiology Analysis. 61
32235375 2020
36
Genome analysis of a multidrug-resistant Streptococcus sanguis isolated from a throat swab of a child with scarlet fever. 61
31698106 2020
37
Brief report: Diagnoses of scarlet fever in Military Health System (MHS) beneficiaries under 17 years of age across the MHS and in England, 2013-2018. 61
32105495 2020
38
Long-term, single-center surveillance of non-invasive group A streptococcal (GAS) infections, emm types and emm clusters. 61
31758439 2020
39
Streptococcal Infection as a Major Historical Cause of Stuttering: Data, Mechanisms, and Current Importance. 61
33304252 2020
40
The rash with mucosal ulceration. 61
32197747 2020
41
Taxonomic studies on Amomum Roxburgh s.l. (Zingiberaceae) in Myanmar II: one new species and five new records for the flora of Myanmar. 61
31988609 2020
42
[Dramatic achievements in infectious disease prevention and treatment in China during the past 70 years]. 61
32062906 2019
43
Epidemiological study of scarlet fever in Shenyang, China. 61
31864293 2019
44
Scarlet fever-the value of microbiological global surveillance. 61
31672693 2019
45
Against the trend: a decrease in scarlet fever in New Zealand. 61
31782393 2019
46
Scarlet fever changes its spots. 61
31519542 2019
47
Emergence of dominant toxigenic M1T1 Streptococcus pyogenes clone during increased scarlet fever activity in England: a population-based molecular epidemiological study. 61
31519541 2019
48
Acute rheumatic fever diagnosis and management: Review of the global implications of the new revised diagnostic criteria with a focus on Saudi Arabia. 61
31516307 2019
49
Immune-Related Comorbidities in Childhood-Onset Obsessive Compulsive Disorder: Lifetime Prevalence in the Obsessive Compulsive Disorder Collaborative Genetics Association Study. 61
31170001 2019
50
Analysis of Epidemiological Characteristics of Scarlet Fever in Zhejiang Province, China, 2004-2018. 61
31533311 2019

Variations for Scarlet Fever

Expression for Scarlet Fever

Search GEO for disease gene expression data for Scarlet Fever.

Pathways for Scarlet Fever

Pathways related to Scarlet Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.9 TNF CRP

GO Terms for Scarlet Fever

Biological processes related to Scarlet Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of glial cell proliferation GO:0060252 9.37 TNF ETV5
2 complement activation, alternative pathway GO:0006957 9.32 CFP C3
3 enteric nervous system development GO:0048484 9.26 EDNRB EDNRA
4 negative regulation of lipid storage GO:0010888 9.16 TNF CRP
5 endothelin receptor signaling pathway GO:0086100 8.96 EDNRB EDNRA
6 vasoconstriction GO:0042310 8.8 EDNRB EDNRA CRP

Molecular functions related to Scarlet Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endothelin receptor activity GO:0004962 8.62 EDNRB EDNRA

Sources for Scarlet Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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