MCID: SCR015
MIFTS: 43

Scarlet Fever

Categories: Immune diseases, Infectious diseases, Oral diseases, Respiratory diseases, Smell/Taste diseases
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Aliases & Classifications for Scarlet Fever

MalaCards integrated aliases for Scarlet Fever:

Name: Scarlet Fever 11 75 53 43 14 63 16 71 31 33
Scarlatina Nos 33
Scarlatina 11

Classifications:



External Ids:

Disease Ontology 11 DOID:8596
ICD9CM 34 034 034.1
MeSH 43 D012541
NCIt 49 C94575
SNOMED-CT 68 154301006 154303009
ICD10 31 A38
ICD11 33 107294155
UMLS 71 C0036285 C0343487

Summaries for Scarlet Fever

PubMed Health : 63 Scarlet fever: Scarlet fever is a bacterial infection that mainly affects children. It usually causes a typical rash, fever and a sore throat. Thanks to antibiotics like penicillin, scarlet fever is easy to treat. Antibiotics can also reduce the time during which children with scarlet fever are contagious. The infection is spread through bacteria-containing droplets and close physical contact. Before the development of penicillin, scarlet fever sometimes led to serious complications. But it’s usually quite a mild illness nowadays. It’s still important to try to stop it from spreading to other people, though. One thing you can do is wash your hands often. Unlike with many other childhood diseases, having had scarlet fever in the past doesn't make you immune to future scarlet fever infections. So people can have it more than once in their lives.

MalaCards based summary: Scarlet Fever, also known as scarlatina nos, is related to rheumatic fever and tonsillitis. An important gene associated with Scarlet Fever is EDNRA (Endothelin Receptor Type A), and among its related pathways/superpathways are Th17 Differentiation and Innate Lymphoid Cells Differentiation. Affiliated tissues include tongue, skin and adrenal cortex, and related phenotypes are digestive/alimentary and cardiovascular system

Disease Ontology: 11 An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash.

Wikipedia: 75 Scarlet fever is an infectious disease resulting from a group A streptococcus (group A strep) infection,... more...

Related Diseases for Scarlet Fever

Diseases related to Scarlet Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 819)
# Related Disease Score Top Affiliating Genes
1 rheumatic fever 31.8 TNF MYOM2 IL6 ALB
2 tonsillitis 30.7 TNF IL6 IL1B
3 fasciitis 30.6 TNF MYOM2 IL6
4 purpura 30.5 TNF IL6 IL1B CRP
5 angina pectoris 30.5 TNF IL6 CRP
6 rubella 30.4 TNF IL6 IL1B
7 hydrops of gallbladder 30.4 ITPKC CRP ALB
8 impetigo 30.4 TST MYOM2 IL6 EDNRB EDNRA
9 toxic shock syndrome 30.3 TNF MYOM2 IL6 IL1B EDNRA CRP
10 nasopharyngitis 30.3 TNF IL6 CRP
11 glomerulonephritis 30.2 TNF IL6 IL1B CRP ALB
12 pericarditis 30.1 TNF IL6 IL1B CRP
13 meningitis 30.1 TNF IL6 IL1B CRP ALB
14 typhoid fever 30.1 TNF IL6 IL1B CRP ALB
15 endocarditis 30.1 TNF IL6 CRP ALB
16 haemophilus influenzae 30.1 TNF IL1B
17 erysipelas 30.1 TNF MYOM2 IL6 IL1B CRP
18 osteomyelitis 30.1 TNF IL6 IL1B CRP
19 kawasaki disease 30.0 TNF ITPKC CRP
20 polyarteritis nodosa 30.0 TNF IL6 CRP
21 brucellosis 30.0 TNF IL6 CRP
22 mumps 30.0 TNF IL6 IL1B
23 tetanus 30.0 TNF IL6 IL1B CRP ALB
24 paratyphoid fever 30.0 TNF IL1B CRP
25 otitis media 30.0 TNF IL6 IL1B FUT2 CRP ALB
26 mastitis 30.0 IL6 EDNRA ALB
27 exanthem 30.0 TNF IL6 IL1B CRP CD4 ALB
28 rheumatic heart disease 29.9 TNF MYOM2 IL6 IL1B
29 neuritis 29.9 TNF IL6 IL1B
30 poliomyelitis 29.9 TNF IL6 CD4 ALB
31 breast abscess 29.8 CRP CD4
32 pleurisy 29.8 TNF IL1B CRP
33 yellow fever 29.8 IL6 IL1B CRP
34 hyperthyroidism 29.8 TNF IL6 CRP ALB
35 lymphangitis 29.8 CRP CD4 ALB
36 parotitis 29.8 CRP CD4 ALB
37 drug allergy 29.8 CRP CD4 ALB
38 pharyngitis 29.7 TNF SPEG MYOM2 IL6 IL1B CRP
39 epidemic typhus 29.7 CRP CD4 ALB
40 neurotic disorder 29.7 TNF IL6 IL1B CRP
41 thyroiditis 29.7 TNF IL6 IL1B CRP
42 proteasome-associated autoinflammatory syndrome 1 29.7 TNF IL6 IL1B CRP ALB
43 hepatitis a 29.7 TNF IL1B CD4 ALB
44 orbital cellulitis 29.7 IL6 CRP CD4
45 otitis externa 29.7 IL6 CRP CD4
46 croup 29.7 IL6 CRP CD4
47 severe acute respiratory syndrome 29.7 TNF IL6 IL1B CRP
48 anemia, autoimmune hemolytic 29.6 IL6 CRP CD4
49 chickenpox 29.6 TNF IL6 IL1B CRP CD4 ALB
50 ritter's disease 29.6 TST SETBP1 EPHX2 EDNRB EDNRA

Graphical network of the top 20 diseases related to Scarlet Fever:



Diseases related to Scarlet Fever

Symptoms & Phenotypes for Scarlet Fever

GenomeRNAi Phenotypes related to Scarlet Fever according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.14 ALB B4GALNT2 CD4 CRP EDNRA EDNRB
2 no effect GR00402-S-2 10.14 ALB CD4 CRP EDNRB EPHX2 ERMAP

MGI Mouse Phenotypes related to Scarlet Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.81 ALB B4GALNT2 CD4 EDNRA EDNRB FUT2
2 cardiovascular system MP:0005385 9.7 ALB B4GALNT2 CRP EDNRA EDNRB EPHX2
3 immune system MP:0005387 9.44 ALB B4GALNT2 CD4 CRP EDNRA EDNRB

Drugs & Therapeutics for Scarlet Fever

PubMed Health treatment related to Scarlet Fever: 63

Scarlet fever is treated with antibiotics – also because that means you will no longer be contagious after 24 hours. They make the symptoms go away a little faster and help to prevent possible complications too. The most commonly used antibiotics for the treatment of scarlet fever are penicillin -based. They are taken two or three times a day for ten days. If someone is allergic to penicillin or it is not well-tolerated, they can take other antibiotics. The possible side effects include nausea , diarrhea and a rash . It’s important to keep taking all the antibiotics even if your symptoms have already gone away. That’s the only way to make sure that all of the germs are killed. Symptoms like a sore throat or fever can be relieved by taking medicine such as ibuprofen or acetaminophen (paracetamol). Other things that may have a soothing effect include sucking throat lozenges, drinking tea or using home remedies such as neck wraps.

Search Clinical Trials, NIH Clinical Center for Scarlet Fever

Cochrane evidence based reviews: scarlet fever

Genetic Tests for Scarlet Fever

Anatomical Context for Scarlet Fever

Organs/tissues related to Scarlet Fever:

MalaCards : Tongue, Skin, Adrenal Cortex, T Cells, Heart, Liver, Kidney

Publications for Scarlet Fever

Articles related to Scarlet Fever:

(show top 50) (show all 2588)
# Title Authors PMID Year
1
[Streptococcal group A carriage: new data on the characteristics of the biology of the causative agent and of the immune response of the host]. 53 62
7856351 1994
2
Erythrogenic toxin type A (ETA): epidemiological analysis of gene distribution and protein formation in clinical Streptococcus pyogenes strains causing scarlet fever and the streptococcal toxic shock-like syndrome (TSLS). 53 62
8219499 1993
3
The indirect impact of control measures in COVID-19 pandemic on the incidence of other infectious diseases in China. 62
35722540 2022
4
Application of logistic differential equation models for early warning of infectious diseases in Jilin Province. 62
36333699 2022
5
Trends in pediatric ambulatory community acquired infections before and during COVID-19 pandemic: A prospective multicentric surveillance study in France. 62
36034052 2022
6
Spatiotemporal dynamics and potential ecological drivers of acute respiratory infectious diseases: an example of scarlet fever in Sichuan Province. 62
36411416 2022
7
The dynamics of scarlet fever in The Netherlands, 1906-1920: a historical analysis. 62
36397968 2022
8
Retrospective study on the effectiveness and safety of the shortened 5- to 7-day antibiotic regimen for acute streptococcal pharyngotonsillitis compared to the classic 10-day regimen. 62
36302708 2022
9
Prevalence and identification of antibiotic-resistant scarlet fever group A Streptococcus strains in some paediatric cases at Shenzhen, China. 62
35618209 2022
10
Public awareness for "classic" childhood diseases and inflammatory syndromes in children during the COVID-19 pandemic. 62
35835017 2022
11
Ten-year prevalence of acute hospital ENT infections and the impact of COVID: A large population study. 62
36068673 2022
12
Characterization of group A beta-haemolytic streptococcus with mucoid phenotype isolated in a tertiary hospital. 62
35570126 2022
13
Collateral Impact of COVID-19 Prevention Measures on Re-Emergence of Scarlet Fever and Pertussis in Mainland China and Hong Kong China. 62
36011545 2022
14
Distribution of emm genotypes in group A streptococcus isolates of Korean children from 2012 to 2019. 62
35624007 2022
15
The secondary outcome of public health measures amidst the COVID-19 pandemic in the spread of other respiratory infectious diseases in Thailand. 62
35523394 2022
16
Modeling the effects of air pollutants and meteorological factors on scarlet fever in five provinces, Northwest China, 2013-2018. 62
35469892 2022
17
Now- and Fore-casting the Secular Epidemiological Trends and Seasonality of the Comeback of Scarlet Fever in China: A 16-year Time Series Analysis. 62
35882418 2022
18
Proteome based mapping and reverse vaccinology techniques to contrive multi-epitope based subunit vaccine (MEBSV) against Streptococcus pyogenes. 62
35231667 2022
19
Decreased Antibiotic Consumption Coincided with Reduction in Bacteremia Caused by Bacterial Species with Respiratory Transmission Potential during the COVID-19 Pandemic. 62
35740153 2022
20
Frequency of transmission, asymptomatic shedding, and airborne spread of Streptococcus pyogenes in schoolchildren exposed to scarlet fever: a prospective, longitudinal, multicohort, molecular epidemiological, contact-tracing study in England, UK. 62
35544097 2022
21
Forecasting the monthly incidence of scarlet fever in Chongqing, China using the SARIMA model. 62
35543101 2022
22
[Demographics of war: mortality in Porto Alegre during Guerra dos Farrapos, 1835-1845]. 62
35674619 2022
23
Rash, red eyes, lip erosions and genital ulcer - What is the diagnosis? 62
35440965 2022
24
Using the MCRISP Network for Surveillance of Pediatric Exanthema in Child Care Centers. 62
32693853 2022
25
Nonshared environmental factors in the aetiology of autism and other neurodevelopmental conditions: a monozygotic co-twin control study. 62
35183250 2022
26
Impact of non-pharmaceutical interventions during COVID-19 pandemic on pertussis, scarlet fever and hand-foot-mouth disease in China. 62
34953908 2022
27
Lactobacillus crispatus DSM25988 as novel bioactive agent to co-aggregate Streptococcus pyogenes and to exclude it by binding to human cells. 62
35144524 2022
28
Prevalence of Infectious Diseases Among 6078 Individuals With Down Syndrome in the United States. 62
35111884 2022
29
Clinical management and impact of scarlet fever in the modern era: findings from a cross-sectional study of cases in London, 2018-2019. 62
34952887 2021
30
Streptococcal superantigens and the return of scarlet fever. 62
34969060 2021
31
Emergence of macrolide-resistant Streptococcus pyogenes emm12 in southern Taiwan from 2000 to 2019. 62
32994137 2021
32
Normal values of antistreptolysin O for adults ages 30 to 70 in Syria: A cross sectional study. 62
34840763 2021
33
Invasive Streptococcus pyogenes disease in Spain: a microbiological and epidemiological study covering the period 2007-2019. 62
34046804 2021
34
Scarlet Fever After Streptococcus pyogenes Skin Infection Associated With FreeStyle Libre Glucose Monitoring. 62
33582045 2021
35
The association between ambient air pollution and scarlet fever in Qingdao, China, 2014-2018: a quantitative analysis. 62
34548016 2021
36
Analysis of spatial-temporal distribution of notifiable respiratory infectious diseases in Shandong Province, China during 2005-2014. 62
34461855 2021
37
Spatiotemporal clustering and meteorological factors affected scarlet fever incidence in mainland China from 2004 to 2017. 62
33684741 2021
38
Infectious Respiratory Diseases Decreased during the COVID-19 Pandemic in South Korea. 62
34205018 2021
39
[Epidemiological characteristics of infectious diseases of group A, B and C among Chinese students' population]. 62
34145851 2021
40
Impact of Nonpharmaceutical Interventions on the Incidence of Respiratory Infections During the Coronavirus Disease 2019 (COVID-19) Outbreak in Korea: A Nationwide Surveillance Study. 62
33150393 2021
41
Use of meteorological parameters for forecasting scarlet fever morbidity in Tianjin, Northern China. 62
33026621 2021
42
Characterization of group A beta-haemolytic streptococcus with mucoid phenotype isolated in a tertiary hospital. 62
33593612 2021
43
Incidence and Effects of Acquisition of the Phage-Encoded ssa Superantigen Gene in Invasive Group A Streptococcus. 62
34149675 2021
44
Identification of epidemic scarlet fever group A Streptococcus strains in the paediatric population of Houston, TX, USA. 62
34816093 2021
45
Scarlet fever in an adult patient: A challenging diagnosis in an airway emergency. 62
34659770 2021
46
Public Health Measures During the COVID-19 Pandemic Reduce the Spread of Other Respiratory Infectious Diseases. 62
34858936 2021
47
Thoughts, beliefs and concepts concerning infectious childhood diseases of physicians practicing homeopathic, anthroposophic and conventional medicine - a qualitative study. 62
33499846 2021
48
[Risk factors for multiple sclerosis in the Kabardino-Balkar Republic]. 62
34387449 2021
49
Molecular Characteristics of Streptococcus pyogenes Isolated From Chinese Children With Different Diseases. 62
34956108 2021
50
Natural or intended mummification? Specific case of a child mummy. 62
33399626 2021

Variations for Scarlet Fever

Expression for Scarlet Fever

Search GEO for disease gene expression data for Scarlet Fever.

Pathways for Scarlet Fever

Pathways related to Scarlet Fever according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.73 IL6 IL1B CD4
2 11.66 TNF IL1B CD4
3
Show member pathways
11.64 IL6 CRP CD4
4 11.62 TNF IL6 IL1B
5 11.59 TNF IL6 CRP
6 11.56 IL6 IL1B CD4
7
Show member pathways
11.56 TNF IL6 IL1B CD4
8
Show member pathways
11.51 TNF IL6 IL1B
9 11.5 TNF IL6 IL1B
10 11.48 TNF IL6 IL1B
11 11.33 IL1B IL6 TNF
12 11.29 TNF IL6 IL1B
13 11.15 TNF IL6 IL1B
14 11.13 TNF IL6 IL1B CD4
15 11.09 TNF IL6 IL1B
16 11.02 TNF IL6 IL1B
17 10.94 TNF IL6 IL1B
18 10.68 IL6 IL1B
19 10.61 TNF IL6 CRP
20 10.39 TNF IL6 IL1B CD4
21
Show member pathways
10.19 TNF IL6

GO Terms for Scarlet Fever

Biological processes related to Scarlet Fever according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 10.11 CRP IL1B IL6 TNF
2 regulation of insulin secretion GO:0050796 10.03 TNF IL6 IL1B
3 positive regulation of chemokine production GO:0032722 9.95 TNF IL6 IL1B
4 negative regulation of neurogenesis GO:0050768 9.93 TNF IL6 IL1B
5 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.92 EDNRA EDNRB IL1B TNF
6 vasoconstriction GO:0042310 9.88 EDNRB EDNRA CRP
7 positive regulation of glial cell proliferation GO:0060252 9.85 TNF IL6 IL1B
8 positive regulation of fever generation GO:0031622 9.84 TNF IL1B
9 heparin metabolic process GO:0030202 9.83 EDNRB EDNRA
10 sequestering of triglyceride GO:0030730 9.8 TNF IL1B
11 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.78 TNF IL1B
12 response to organic substance GO:0010033 9.74 TNF EDNRB EDNRA
13 renal albumin absorption GO:0097018 9.73 EDNRA EDNRB
14 positive regulation of neuroinflammatory response GO:0150078 9.73 TNF IL6 IL1B
15 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP
16 regulation of biological quality GO:0065008 9.33 TNF EDNRB EDNRA
17 vascular endothelial growth factor production GO:0010573 9.1 TNF IL6 IL1B

Molecular functions related to Scarlet Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endothelin receptor activity GO:0004962 8.92 EDNRB EDNRA

Sources for Scarlet Fever

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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