Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: SCH014
MIFTS: 61

Schistosomiasis

Categories: Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Schistosomiasis

About this section

MalaCards integrated aliases for Schistosomiasis:

Name: Schistosomiasis 12 76 53 55 3 44 15 73
Katayama Fever 53 73
Bilharzia 53 3
Schistosoma Mansoni Infection 53
Schistosomiasis Mansoni 73
Blood Fluke 53

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1395
ICD9CM 35 120.8
MeSH 44 D012552
Sources

Summaries for Schistosomiasis

About this section
NIH Rare Diseases : 53 Schistosomiasis is a disease caused by parasitic worms. Although the worms that cause schistosomiasis are not found in the United States, more than 200 million people are infected worldwide. Infection occurs through contact with contaminated water. The parasite in its infective stages is called a cercaria. It swims freely in open bodies of water. On contact with humans, the parasite burrows into the skin, matures into another stage (schistosomula), then migrates to the lungs and liver, where it matures into the adult form. The adult worm then migrates to its preferred body part (bladder, rectum, intestines, liver, portal venous system (the veins that carry blood from the intestines to liver, spleen, lungs), depending on its species.  Schistosomiasis is common in many tropical and subtropical areas worldwide. It can be treated safely and effectively with praziquantel.

MalaCards based summary : Schistosomiasis, also known as katayama fever, is related to intestinal schistosomiasis and urinary schistosomiasis. An important gene associated with Schistosomiasis is IL4 (Interleukin 4), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Lumefantrine and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and skin, and related phenotypes are homeostasis/metabolism and hematopoietic system

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

CDC : 3  

Wikipedia : 76 Schistosomiasis, also known as snail fever and bilharzia, is a disease caused by parasitic flatworms... more...

Sources

Related Diseases for Schistosomiasis

About this section

Diseases related to Schistosomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 450)
# Related Disease Score Top Affiliating Genes
1 intestinal schistosomiasis 34.3 ARG1 IL13 IL4 IL5
2 urinary schistosomiasis 34.0 IFNG IL13 IL4 IL5 RNASE3
3 portal hypertension 30.7 ALB F2 TNF
4 hepatitis b 30.6 ALB F2 IFNG TNF
5 fascioliasis 30.5 ALB IFNG IL10
6 appendicitis 30.5 ALB IL10 TNF
7 strongyloidiasis 30.5 IFNG IL13 IL5
8 filarial elephantiasis 30.4 IL10 IL4 IL5
9 endomyocardial fibrosis 30.3 IL10 IL4 TNF
10 paragonimiasis 30.2 IL13 IL5 RNASE3
11 salmonellosis 30.1 ALB IFNG IFNGR1
12 viral hepatitis 30.1 ALB F2 TNF
13 plasmodium falciparum malaria 30.1 IFNG IL10 TNF
14 onchocerciasis 30.0 IL13 IL2 IL4 IL5 RNASE3
15 filariasis 30.0 ALB IFNG IL10 IL2 IL5 TNF
16 toxoplasmosis 29.9 CD40LG IFNG IL10 IL4 TNF
17 echinococcosis 29.9 IFNG IL10 IL5 TNF
18 eosinophilic pneumonia 29.9 IL13 IL5 RNASE3
19 parasitic helminthiasis infectious disease 29.9 IL10 IL13 IL2 IL4 IL5 RNASE3
20 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 29.9 CD40LG IFNG IL10 IL2 IL4
21 neuritis 29.8 IFNG IL4 TNF
22 hypersplenism 29.8 ALB F2 IFNG IL4
23 hepatic encephalopathy 29.8 ALB F2 TNF
24 tropical endomyocardial fibrosis 29.8 IL10 IL4 TNF
25 clonorchiasis 29.7 IFNG IL10 IL2 TNF
26 trichuriasis 29.7 IL10 IL13 RNASE3 TNF
27 tetanus 29.7 CD40LG IFNG IL10 IL13 IL2 IL4
28 buruli ulcer 29.7 CD40LG IFNG IL10 IL4
29 poliomyelitis 29.7 IFNG IL10 IL4 TNF
30 dermatitis 29.6 IFNG IGHE IL13 IL4 IL5
31 chlamydia 29.6 IFNG IL10 IL4 TNF
32 alcoholic liver cirrhosis 29.6 ALB F2 GSTM1
33 hepatitis e 29.5 ALB CD40LG F2 IFNG TNF
34 smallpox 29.5 IFNG IL2 TNF
35 lymphadenitis 29.5 IFNG IFNGR1 IL10 TNF
36 meningitis 29.4 ALB CCL3 IFNG IL10 TNF
37 dermatitis, atopic 29.4 IFNG IGHE IL10 IL13 IL2 IL4
38 pneumonia 29.4 CCL3 CD40LG IL10 IL13 IL5 TNF
39 mycobacterium tuberculosis 1 29.4 IFNG IFNGR1 IL10 IL4 TNF
40 trypanosomiasis 29.4 ALB CCL3 IFNG IL10 IL2 IL4
41 typhoid fever 29.4 ALB F2 IFNG IFNGR1 TNF
42 lung disease 29.4 CCL3 IL10 IL13 IL5 RNASE3 TNF
43 viral infectious disease 29.4 CCL3 CD40LG IFNG IL10 IL2 IL4
44 human immunodeficiency virus type 1 29.2 CCL3 IFNG IL10 IL2 TNF
45 colitis 29.2 IFNG IL10 IL2 IL4 TNF
46 human immunodeficiency virus infectious disease 29.2 CCL3 IFNG IL10 IL2 TNF
47 malaria 29.1 ALB CCL3 CD40LG GAPDH IFNG IFNGR1
48 chagas disease 29.1 CCL3 IFNG IL10 IL2 TNF
49 paracoccidioidomycosis 29.1 IFNG IL10 IL2 IL4 IL5 TNF
50 leprosy 3 29.1 ALB IFNG IL10 IL2 IL4 TNF

Graphical network of the top 20 diseases related to Schistosomiasis:



Diseases related to Schistosomiasis
Sources

Symptoms & Phenotypes for Schistosomiasis

About this section

MGI Mouse Phenotypes related to Schistosomiasis:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 ALB ARG1 CD40LG F2 IFNG IFNGR1
2 hematopoietic system MP:0005397 10.23 ARG1 CD40LG F2 IFNG IFNGR1 IL10
3 digestive/alimentary MP:0005381 10.19 ALB F2 IFNG IFNGR1 IL10 IL13
4 immune system MP:0005387 10.18 ARG1 CD40LG F2 IFNG IFNGR1 IL10
5 endocrine/exocrine gland MP:0005379 10.13 ALB CD40LG IFNG IFNGR1 IL10 IL13
6 liver/biliary system MP:0005370 10.02 ALB ARG1 IFNG IFNGR1 IL10 IL2
7 integument MP:0010771 9.97 CD40LG F2 IFNG IFNGR1 IL10 IL13
8 reproductive system MP:0005389 9.85 CD40LG F2 IFNG IFNGR1 IL10 IL13
9 neoplasm MP:0002006 9.8 ALB IFNG IFNGR1 IL10 IL2 IL5
10 respiratory system MP:0005388 9.56 F2 IFNG IL10 IL13 IL2 IL4
11 skeleton MP:0005390 9.28 CD40LG F2 IFNG IFNGR1 IL10 IL13
Sources

Drugs & Therapeutics for Schistosomiasis

About this section

Drugs for Schistosomiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lumefantrine Approved Phase 4 82186-77-4 6437380
2
Albendazole Approved, Vet_approved Phase 4,Phase 3,Not Applicable 54965-21-8 2082
3
Artemether Approved Phase 4 71963-77-4 119380 68911
4
Praziquantel Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55268-74-1 4891
5
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
6
Pyrimethamine Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 58-14-0 4993
7
Sulfadoxine Approved, Investigational Phase 4,Phase 3,Phase 2 2447-57-6 17134
8
leucovorin Approved Phase 4,Phase 2,Phase 3 58-05-9 6006 143
9
Amodiaquine Approved, Investigational Phase 4 86-42-0 2165
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
11
Piperaquine Experimental, Investigational Phase 4,Phase 3 4085-31-8 5079497
12 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Not Applicable
13 Anthelmintics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
14 Antimitotic Agents Phase 4,Phase 3,Not Applicable
15 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Artemether-lumefantrine combination Phase 4
17 Artemisinine Phase 4,Phase 2,Phase 3
18 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Antifungal Agents Phase 4
20 Antimalarials Phase 4,Phase 2,Phase 3
21 Artemisinins Phase 4,Phase 2,Phase 3
22 Vitamin B9 Phase 4,Phase 2,Phase 3
23 Renal Agents Phase 4,Phase 2,Phase 3
24 Folate Phase 4,Phase 2,Phase 3
25 Vitamin B Complex Phase 4,Phase 2,Phase 3
26 Fanasil, pyrimethamine drug combination Phase 4,Phase 3,Phase 2
27 Folic Acid Antagonists Phase 4,Phase 2,Phase 3
28 Anti-Infective Agents, Urinary Phase 4,Phase 2,Phase 3
29
Myrrh Approved Phase 3 9000-45-7
30
Artesunate Approved, Investigational Phase 2, Phase 3 88495-63-0 5464098 6917864
31
Iron Approved Phase 3,Not Applicable 7439-89-6 23925
32
Tranexamic Acid Approved Phase 3 1197-18-8 5526
33 Triclabendazole Investigational Phase 3 68786-66-3
34 Vitamins Phase 3,Not Applicable
35 Micronutrients Phase 3,Not Applicable
36 Trace Elements Phase 3,Not Applicable
37 Immunologic Factors Phase 3,Phase 2,Phase 1
38 Vaccines Phase 3,Phase 2,Phase 1
39 Sulfalene Phase 2, Phase 3
40 Iron Supplement Phase 3,Not Applicable
41 Antifibrinolytic Agents Phase 3
42 Coagulants Phase 3
43 Hemostatics Phase 3
44 Ferric Compounds Phase 3
45 Hematinics Phase 3
46
Mefloquine Approved, Investigational Phase 2 53230-10-7 4046
47 Pharmaceutical Solutions Phase 2,Phase 1,Not Applicable
48
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
49
Aluminum sulfate Approved Phase 1 10043-01-3
50 Adjuvants, Immunologic Phase 1

Interventional clinical trials:

(show top 50) (show all 69)
# Name Status NCT ID Phase Drugs
1 Artemisinin-based Combination Therapy-Intermittent Preventive Treatment (ACT-IPT) Trial Among Schoolchildren in Kassena-Nankana, Ghana Unknown status NCT01459146 Phase 4 Artemether-lumefantrine combination plus albendazole;Artemether-lumefantrine plus Praziquantel plus Albendazole;Albendazole plus Praziquantel
2 Effect of Schistosomiasis Mansoni on HIV Susceptibility and Female Genital Immunology Completed NCT02878564 Phase 4 Praziquantel
3 Evaluation of Praziquantel Dosage for Treatment of Schistosomiasis in Brazil Completed NCT00403611 Phase 4 Praziquantel 60 mg/kg;Praziquantel 40 mg/kg
4 A Multinational Trial of the Efficacy of Albendazole Against Soil-transmitted Nematode Infections in Children Completed NCT01087099 Phase 4 Albendazole
5 Intermittent Preventive Treatment to Shrink the Malaria Reservoir and relaTed Morbidities by Targeting School Children in Regions With Different Malaria Endemicities Not yet recruiting NCT03640403 Phase 4 Sulfadoxine-Pyrimethamine;Piperaquine;Amodiaquine
6 Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis Withdrawn NCT02734186 Phase 4 Praziquantel
7 Safety and Efficacy of Mirazid for Schistosomiasis Treatment Completed NCT01529710 Phase 3 Myrrh
8 Efficacy of Bilhvax in Association With Praziquantel for Prevention of Clinical Recurrences of Schistosoma Haematobium Completed NCT00870649 Phase 3
9 Schistosoma Haematobium Infections and Praziquantel Completed NCT01558336 Phase 3 praziquantel
10 Comparing Praziquantel Versus Artesunate + Sulfamethoxypyrazine/Pyrimethamine for Treating Schistosomiasis Completed NCT00510159 Phase 2, Phase 3 Artesunate+Sulfamethoxypyrazine/pyrimethamin;Praziquantel
11 Impact IPT With Sulfadoxine-pyrimethamine or Sulfadoxine-pyrimethamine Plus Piperaquine in Schoolchildren Completed NCT01722539 Phase 3 Sulfadoxine-pyrimethamine;Piperaquine;Albendazole;Praziquantel
12 The Chinese-made Praziquantel for Treatment of Schistosoma Haematobium Recruiting NCT03133832 Phase 3 Companion Tablet
13 Haemorrhage Alleviation With Tranexamic Acid- Intestinal System Recruiting NCT01658124 Phase 3 Tranexamic Acid;Placebo
14 IV Ferric Carboxymaltose Compared With Oral Iron in the Treatment of Iron Deficiency Anemia at Delivery in Tanzania Active, not recruiting NCT02541708 Phase 3 Ferric carboxymaltose;Ferrous sulfate + folic acid
15 Repeated Doses of Praziquantel in Schistosomiasis Treatment (RePST) Not yet recruiting NCT02868385 Phase 3 4x Praziquantel;1x Praziquantel
16 Schistosomiasis Diagnosis Using a CAA Antigen Test Not yet recruiting NCT03779347 Phase 3 Praziquantel
17 Activity of Mefloquine Against Urinary Schistosomiasis Completed NCT01132248 Phase 2 Mefloquine;S/P
18 An Open Label Dose Finding Safety and Efficacy in Children and Infants Infected With Schistosomiasis (S.Mansoni) Completed NCT02806232 Phase 2 Biltricide (racemate praziquantel) oral tablets;Racemate Praziquantel ODT;Levo Praziquantel ODT
19 Schistosoma Mansoni Morbidity in Children Aged 1-5 Years Completed NCT01901484 Phase 2 Praziquantel
20 S. Japonicum and Pregnancy Outcomes Completed NCT00486863 Phase 2 Praziquantel
21 Study of Safety and Immune Response of the Sm14 Vaccine in Adults of Endemic Regions Completed NCT03041766 Phase 2 GLA-SE solution
22 Trial to Investigate the Effect of Schistosoma Mansoni Infection on the Response to Vaccination With MVA85A in BCG-vaccinated African Adolescents Completed NCT02178748 Phase 2
23 Anti-Schistosomiasis Vaccine: Sm14 Phase 2b-Sn in School Children Active, not recruiting NCT03799510 Phase 2 GLA-SE solution
24 Praziquantel in Children Under Age 4 Not yet recruiting NCT03640377 Phase 2 Praziquantel
25 Study to Evaluate the Safety of the Vaccine Prepared sm14 Against Schistosomiasis Completed NCT01154049 Phase 1
26 Clinical Trial of Bilhvax,a Vaccine Candidate Against Schistosomiasis Completed NCT01512277 Phase 1
27 A Phase I Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel® With or Without GLA-AF for Intestinal Schistosomiasis in Healthy Adults Completed NCT02337855 Phase 1
28 Praziquantel-Pharmacokinetic Study Completed NCT01288872 Phase 1 Praziquantel
29 Safety and Immunogenicity Study of a DNA Vaccine Combined With Protein Vaccine Against HIV/AIDS Completed NCT02376582 Phase 1
30 A Phase Ib Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel)(R) With or Without AP 10-701 for Intestinal Schistosomiasis in Healthy Exposed Adults Recruiting NCT03110757 Phase 1
31 Controlled Human Infection for Vaccination Against Streptococcus Pyogenes Recruiting NCT03361163 Phase 1
32 Evaluation of Strategies for Improved Uptake of Preventive Treatment for Intestinal Schistosomiasis Unknown status NCT01869465 Not Applicable
33 Antioxidant Supplements in the Reversal of Schistosomal Peri-portal Fibrosis Unknown status NCT01260012 Not Applicable
34 A Study of Co-infections of HIV-1 and Schistosoma Mansoni and Its Impact on Praziquantel Treatment Outcomes Unknown status NCT01541631 Not Applicable Praziquantel and Albendazole;Praziquantel and Albendazole;Praziquantel and Albendazole
35 Health Benefits of Repeated Treatment in Pediatric Schistosomiasis Completed NCT01424410
36 Childhood Schistosomiasis: a Novel Strategy Extending the Benefits/Reach of Antihelminthic Treatment Completed NCT02495909
37 Arachidonic Acid Treatment Against Schistosomiasis Infection in Children Completed NCT02144389 Not Applicable Praziquantel (PZQ)
38 Women and Children as the Focus for Control of Schistosomiasis Infections in the Irrigations Area of Burkina Faso Completed NCT00463528
39 Assessment of Anaemia Attributable to Schistosomiasis in School Children in Kenya: Mechanisms and Effect of Treatment Completed NCT00414479 praziquantl, iron, ACT
40 Urinary Schistosomiasis Infection Completed NCT00138450
41 Schistosomiasis in Women of Reproductive Age in Burkina Faso: Implications for Control Completed NCT00463632
42 Evaluation of the Use of a Urin Test Strip to Determine the Spread of Schistosoma Infections in Areas Where Schistosomiasis Infections Are Low in Kenya Completed NCT00463307
43 Schistosomiasis in Formal and Non-Formal Schools in Uganda: Implications for Control Programmes Completed NCT00463593
44 Using Community-Based Volunteers to Reach Non-Enrolled School Aged Children Through Community-Directed Treatment of Schistosomiasis in School-Aged Children in Rural Northern Ghana Completed NCT00463931
45 Urogenital Schistosomiasis and Sexually Transmitted Infections in Madagascar Completed NCT00713999 Not Applicable Treatment with anti-STI and anti-schistosoma regimens
46 Iron Supplementation in Schistosomiasis and Soil Transmitted Helminths Control Programmes in Zambia Completed NCT00276224 Not Applicable ferrous sulphate (drug)
47 Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal Completed NCT01553552
48 Treatment Schistosomal Portal Hypertension: Efficacy of Endoscopy or Surgery Completed NCT01931826 Not Applicable
49 The Effect of Praziquantel Treatment on Schistosoma Mansoni Morbidity and re-Infection Along Lake Victoria, Uganda Completed NCT00215267 Not Applicable praziquantel
50 Worm Infestation and Child Health in Zimbabwe Completed NCT01283165

Search NIH Clinical Center for Schistosomiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: schistosomiasis

Sources

Genetic Tests for Schistosomiasis

About this section
Sources

Anatomical Context for Schistosomiasis

About this section

MalaCards organs/tissues related to Schistosomiasis:

41
Liver, Testes, Skin, Spleen, Kidney, Lung, T Cells
Sources

Publications for Schistosomiasis

About this section

Articles related to Schistosomiasis:

(show top 50) (show all 2972)
# Title Authors Year
1
A case of acute appendicitis due to intestinal schistosomiasis. ( 30555690 )
2019
2
Schistosomiasis in immigrants, refugees and travellers in an Italian referral centre for tropical diseases. ( 29907162 )
2018
3
Dataset on usnic acid from <i>Cladonia substellata</i> Vainio (Lichen) schistosomiasis mansoni's vector control and environmental toxicity. ( 29876395 )
2018
4
Praziquantel for the treatment of schistosomiasis during human pregnancy. ( 29403101 )
2018
5
Schistosomiasis in a returning international traveler with cyclic fevers and diarrhea. ( 29449243 )
2018
6
18F-NaF PET/CT Finding in a Patient With Abdominal Discomfort After Schistosomiasis. ( 29356743 )
2018
7
Underestimation of the global burden of schistosomiasis. ( 29413041 )
2018
8
Eggs and Magnetism: New Approaches for Schistosomiasis Diagnosis. ( 29422443 )
2018
9
Urinary schistosomiasis presented as bladder malignancy with pulmonary metastases: a case report. ( 29962297 )
2018
10
The current epidemiological status of urogenital schistosomiasis among primary school pupils in Katsina State, Nigeria: An imperative for a scale up of water and sanitation initiative and mass administration of medicines with Praziquantel. ( 29979684 )
2018
11
Infection status and risk factors associated with urinary schistosomiasis among school-going children in the Ndumo area of uMkhanyakude District in KwaZulu-Natal, South Africa two years post-treatment. ( 29679769 )
2018
12
Gastric fundus splenosis with hemangioma masquerading as a gastrointestinal stromal tumor in a patient with schistosomiasis and cirrhosis who underwent splenectomy: A case report and literature review. ( 29979450 )
2018
13
Schistosomiasis as a cause of acute cholecystitis. ( 29968897 )
2018
14
The use of gold nanorods as a new vaccine platform against schistosomiasis. ( 29428201 )
2018
15
Estimating the prevalence of schistosomiasis japonica in China: a serological approach. ( 29961423 )
2018
16
The epidemiology of schistosomiasis in Lango region Uganda 60 years after Schwetz 1951: Can schistosomiasis be eliminated through mass drug administration without other supportive control measures? ( 29935144 )
2018
17
Hepatic schistosomiasis with massive splenomegaly: a case report and literature review. ( 29562382 )
2018
18
Defining the Pathways of Urogenital Schistosomiasis-Associated Urothelial Carcinogenesis through Transgenic and Bladder Wall Egg Injection Models. ( 28889378 )
2018
19
Prevalence of schistosomiasis mansoni in indigenous Maxakali villages, Minas Gerais, Brazil. ( 29972467 )
2018
20
A rare cause of diarrhea in the occident: A case of colonic schistosomiasis. ( 29887404 )
2018
21
Capacity gaps in health facilities for case management of intestinal schistosomiasis and soil-transmitted helminthiasis in Burundi. ( 29970181 )
2018
22
Low incidence of helminth infections (schistosomiasis, strongyloidiasis, filariasis, toxocariasis) among Dutch long-term travelers: A prospective study, 2008-2011. ( 29847574 )
2018
23
Schistosomiasis detected during appendectomy. ( 29976471 )
2018
24
Could diet composition modulate pathological outcomes in schistosomiasis mansoni? A systematic review of in vivo preclinical evidence. ( 29400268 )
2018
25
Impact of Mothers' Schistosomiasis Status During Gestation on Children's IgG Antibody Responses to Routine Vaccines 2a88Years Later and Anti-Schistosome and Anti-Malarial Responses by Neonates in Western Kenya. ( 29967622 )
2018
26
Schistosomiasis in Africa: Improving strategies for long-term and sustainable morbidity control. ( 29953454 )
2018
27
The Spatial-Temporal Trend Analysis of Schistosomiasis from 1997 to 2010 in Anhui Province, Eastern China. ( 29436347 )
2018
28
Post-transplant liver graft schistosomiasis in a migrant from Sub-Saharan Africa, Italy 2017. ( 29890019 )
2018
29
Field and laboratory comparative evaluation of a LAMP assay for the diagnosis of urogenital schistosomiasis in Cubal, Central Angola. ( 29920859 )
2018
30
Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis. ( 29744736 )
2018
31
Evaluation of transient elastography in assessing liver fibrosis in patients with advanced schistosomiasis japonica. ( 29355611 )
2018
32
Expanding molecular diagnostics of helminthiasis: Piloting use of the GPLN platform for surveillance of soil transmitted helminthiasis and schistosomiasis in Ghana. ( 29370166 )
2018
33
Historical perspective: Revisiting the St. Lucia Project, a multi-year comparison trial of schistosomiasis control strategies. ( 29385131 )
2018
34
Quality of life and quality-adjusted life years of chronic schistosomiasis mansoni patients in Brazil in 2015. ( 29945168 )
2018
35
Arsenicosis in bladder pathology and schistosomiasis in Eggua, Nigeria. ( 29868729 )
2018
36
An Integrated Approach to Control Soil-Transmitted Helminthiasis, Schistosomiasis, Intestinal Protozoa Infection, and Diarrhea: Protocol for a Cluster Randomized Trial. ( 29895511 )
2018
37
Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules. ( 29401734 )
2018
38
Paediatric schistosomiasis: What we know and what we need to know. ( 29420537 )
2018
39
Knowledge, attitudes and practices on Schistosomiasis in sub-Saharan Africa: a systematic review. ( 29347919 )
2018
40
Study of diagnostic accuracy of Helmintex, Kato-Katz, and POC-CCA methods for diagnosing intestinal schistosomiasis in Candeal, a low intensity transmission area in northeastern Brazil. ( 29518081 )
2018
41
Intestinal Schistosomiasis: A Rare Cause of Abdominal Pain and Weight loss. ( 29560299 )
2018
42
Rifaximin Reduces Markers of Inflammation and Bacterial 16S rRNA in Zambian Adults with Hepatosplenic Schistosomiasis: A Randomized Control Trial. ( 29436337 )
2018
43
Evaluation of diagnostic methods for the detection of intestinal schistosomiasis in endemic areas with low parasite loads: Saline gradient, Helmintex, Kato-Katz and rapid urine test. ( 29470516 )
2018
44
Under diagnosis of intestinal schistosomiasis in a referral hospital, North Ethiopia. ( 29661251 )
2018
45
Mass drug administration and the sustainable control of schistosomiasis: Community health workers are vital for global elimination efforts. ( 29128644 )
2018
46
Praziquantel Targets M1 Macrophages and Ameliorates Splenomegaly in Chronic Schistosomiasis. ( 29061758 )
2018
47
Underestimation of the global burden of schistosomiasis - Authors' reply. ( 29413043 )
2018
48
Effectiveness of vinpocetine and isosorbide-5-mononitrate on experimental schistosomiasis mansoni: Biochemical and immunohistochemical study. ( 29963994 )
2018
49
Surveillance of intestinal schistosomiasis during control: a comparison of four diagnostic tests across five Ugandan primary schools in the Lake Albert region. ( 29560841 )
2018
50
Schistosomiasis and Strongyloidiasis Recommendations for Solid-Organ Transplant Recipients and Donors. ( 29381575 )
2018
Sources

Variations for Schistosomiasis

About this section
Sources

Expression for Schistosomiasis

About this section
Search GEO for disease gene expression data for Schistosomiasis.
Sources

Pathways for Schistosomiasis

About this section

Pathways related to Schistosomiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.09 ARG1 CCL3 CD40LG IFNG IFNGR1 IGHE
2
PEDF Induced Signaling 64
Show member pathways
 13.74 CCL3 CD40LG F2 IFNG IFNGR1 IL10
3
TGF-Beta Pathway 64
Show member pathways
 13.61 CCL3 F2 IFNG IFNGR1 IL10 IL13
4
Akt Signaling 64
Show member pathways
 13.45 CCL3 CD40LG IL10 IL13 IL2 IL4
5
Cytokine Signaling in Immune system 66
Show member pathways
 13.42 CCL3 CD40LG IFNG IFNGR1 IGHE IL10
6
PAK Pathway 64
Show member pathways
 13.35 CCL3 CD40LG IL10 IL13 IL2 IL4
7
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13.05 CCL3 IFNG IFNGR1 IL10 IL2 TNF
8
Pathways in cancer 37
12.92 GSTM1 IFNG IFNGR1 IL13 IL2 IL4
9
Influenza A 37
Show member pathways
 12.85 IFNG IFNGR1 IL13 IL2 IL4 TNF
10
Allograft rejection 1 37
Show member pathways
 12.8 CD40LG IFNG IFNGR1 IL10 IL13 IL2
11
Immune response NFAT in immune response 22
Show member pathways
 12.7 CD40LG IFNG IFNGR1 IGHE IL10 IL2
12
NF-kappaB Signaling 4
12.65 CD40LG IFNG IL10 IL2 IL4 TNF
13
Th17 cell differentiation 37
Show member pathways
 12.65 IFNG IFNGR1 IL10 IL13 IL2 IL4
14
Immune response IL-23 signaling pathway 22
Show member pathways
 12.64 F2 IFNG IL10 IL2 TNF
15
Immune response Fc epsilon RI pathway 22
Show member pathways
 12.63 IGHE IL13 IL4 IL5 TNF
16
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.57 IFNG IFNGR1 IL2 IL4 TNF
17
T cell receptor signaling pathway 37
Show member pathways
 12.53 CD40LG IFNG IL10 IL2 IL4 IL5
18
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.5 IFNG IFNGR1 IL10 IL13 IL2 IL4
19
Selenium Micronutrient Network 1
Show member pathways
 12.43 ALB F2 IFNG IL2 IL4 TNF
20
IL-17 Family Signaling Pathways 65
Show member pathways
 12.41 IFNG IL13 IL4 IL5 TNF
21
Toxoplasmosis 37
Show member pathways
 12.37 CD40LG IFNG IFNGR1 IL10 IL4 TNF
22
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.36 IFNG IL10 IL13 IL2 IL4 IL5
23
Tuberculosis 37
12.27 IFNG IFNGR1 IL10 TNF
24
Bacterial infections in CF airways 22
Show member pathways
 12.23 IFNG IFNGR1 IL4 TNF
25
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.22 GAPDH IL10 IL13 TNF
26
Th1 Differentiation Pathway 65
Show member pathways
 12.15 IFNG IFNGR1 IL10 IL2 TNF
27
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 12.14 F2 IFNG IL13 IL4 TNF
28
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.14 CCL3 IFNG IFNGR1 IL10 IL13 IL2
29
Spinal Cord Injury 1
12.11 ARG1 IFNG IL2 IL4 TNF
30
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
12.09 IFNG IL10 IL2 IL4 IL5 TNF
31
Interleukin-4 and 13 signaling 66
12.08 IGHE IL10 IL13 IL4 TNF
32
IL12-mediated signaling events 1
Show member pathways
 12.04 CCL3 IFNG IL2 IL4
33
Amoebiasis 37
11.96 ARG1 IFNG IL10 TNF
34
Jak-Stat Signaling Pathway (sino) 67
11.94 IFNG IFNGR1 IL10 IL2
35
Glucocorticoid receptor regulatory network 1
11.92 IFNG IL13 IL2 IL4 IL5
36
Hematopoietic cell lineage 37
11.89 IL4 IL5 TNF
37
Rheumatoid arthritis 37
11.86 CCL3 IFNG TNF
38
Dendritic Cells Developmental Lineage Pathway 65
11.84 IFNG IL10 IL2 TNF
39
Salmonella infection (KEGG) 37
11.83 CCL3 IFNG IFNGR1
40
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.81 CD40LG IFNG IL2 IL4 IL5 TNF
41
Lung fibrosis 1
11.78 CCL3 IL13 IL4 IL5 TNF
42
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.77 CD40LG IFNG IL2 TNF
43
IL4-mediated signaling events 1
11.71 ARG1 CD40LG IGHE IL10 IL4 IL5
44
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.68 IFNG IL2 TNF
45
Innate Lymphoid Cell Differentiation Pathways 65
11.66 CCL3 IFNG IL10 IL13 IL2 IL4
46
Interleukin-10 signaling 66
11.65 CCL3 IL10 IL13 IL4 TNF
47
Malaria 37
11.64 CD40LG IFNG IL10 TNF
48
Photodynamic therapy-induced AP-1 survival signaling. 1
11.6 IFNG IL2 TNF
49
Cellular Transformation by HTLV1 64
Show member pathways
 11.59 IFNG IFNGR1 TNF
50
Aryl Hydrocarbon Receptor Pathway 1
11.57 IFNG IL2 TNF
Sources

GO Terms for Schistosomiasis

About this section

Cellular components related to Schistosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 ALB ARG1 CCL3 CD40LG F2 IFNG
2 external side of plasma membrane GO:0009897 9.55 CD40LG F2 IGHE IL13 TNF
3 extracellular region GO:0005576 9.53 ALB ARG1 CCL3 CD40LG F2 IFNG

Biological processes related to Schistosomiasis according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.96 CCL3 IFNG LGMN TNF
2 defense response to bacterium GO:0042742 9.94 IGHE IL10 RNASE3 TNF
3 MAPK cascade GO:0000165 9.92 CCL3 IL2 IL5 TNF
4 positive regulation of protein phosphorylation GO:0001934 9.87 F2 IFNG IL2 TNF
5 inflammatory response GO:0006954 9.85 CCL3 CD40LG IL10 IL13 IL5 TNF
6 immune response GO:0006955 9.85 CCL3 CD40LG IFNG IGHE IL10 IL13
7 response to organic substance GO:0010033 9.84 IL10 SERPINF2 TNF
8 positive regulation of inflammatory response GO:0050729 9.81 CCL3 IL2 TNF
9 B cell differentiation GO:0030183 9.8 CD40LG IL10 IL4
10 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.79 F2 GAPDH RNASE3
11 positive regulation of T cell proliferation GO:0042102 9.77 CD40LG IL2 IL4
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.75 IL13 SERPINF2 TNF
13 negative regulation of endothelial cell apoptotic process GO:2000352 9.69 IL10 IL13 IL4
14 cellular response to hepatocyte growth factor stimulus GO:0035729 9.67 IL10 LGMN
15 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.66 IFNG IFNGR1
16 positive regulation of immunoglobulin secretion GO:0051024 9.65 IL2 IL5
17 positive regulation of podosome assembly GO:0071803 9.65 IL5 TNF
18 negative regulation of fibrinolysis GO:0051918 9.63 F2 SERPINF2
19 positive regulation of isotype switching to IgG isotypes GO:0048304 9.63 IL2 IL4
20 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.62 IFNG IL13 IL2 IL4
21 endothelial cell apoptotic process GO:0072577 9.61 IL10 TNF
22 positive regulation of cytokine secretion GO:0050715 9.61 GAPDH IL10 TNF
23 cytokine-mediated signaling pathway GO:0019221 9.61 CCL3 IFNGR1 IGHE IL10 IL13 IL2
24 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL10 IL4
25 negative regulation of cytokine secretion involved in immune response GO:0002740 9.56 IL10 TNF
26 positive regulation of B cell proliferation GO:0030890 9.56 IL13 IL2 IL4 IL5
27 regulation of immunoglobulin secretion GO:0051023 9.55 CD40LG TNF
28 regulation of isotype switching GO:0045191 9.54 IL10 IL4
29 type 2 immune response GO:0042092 9.52 IL10 IL4
30 negative regulation of complement-dependent cytotoxicity GO:1903660 9.49 IL13 IL4
31 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 IFNG TNF
32 receptor biosynthetic process GO:0032800 9.46 IL10 TNF
33 positive regulation of vitamin D biosynthetic process GO:0060557 9.4 IFNG TNF
34 regulation of signaling receptor activity GO:0010469 9.32 CCL3 CD40LG F2 IFNG IL10 IL13
35 positive regulation of cell proliferation GO:0008284 10.07 F2 IFNG IL2 IL5 LGMN
36 positive regulation of gene expression GO:0010628 10 CCL3 IFNG IL13 IL4 TNF

Molecular functions related to Schistosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 F2 IL10 IL2 IL4 IL5
2 cytokine activity GO:0005125 9.28 CCL3 CD40LG IFNG IL10 IL13 IL2
Sources

Sources for Schistosomiasis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....