MCID: SCH004
MIFTS: 25

Schizoid Personality Disorder

Categories: Mental diseases

Aliases & Classifications for Schizoid Personality Disorder

MalaCards integrated aliases for Schizoid Personality Disorder:

Name: Schizoid Personality Disorder 12 76 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10936
ICD10 33 F60.1
ICD9CM 35 301.2 301.20
MeSH 44 D012557
NCIt 50 C92631
SNOMED-CT 68 52954000
UMLS 73 C0036339

Summaries for Schizoid Personality Disorder

Disease Ontology : 12 A personality disorder that is characterized by a lack of interest in social relationships, a tendency towards a solitary lifestyle, secretiveness, emotional coldness and sometimes sexual apathy, with a simultaneous rich, elaborate and exclusively internal fantasy world.

MalaCards based summary : Schizoid Personality Disorder is related to personality disorder and alexithymia. An important gene associated with Schizoid Personality Disorder is PIR (Pirin), and among its related pathways/superpathways are Apoptosis and Autophagy and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Atomoxetine Hydrochloride and Neurotransmitter Agents have been mentioned in the context of this disorder.

Wikipedia : 76 Schizoid personality disorder (/�?skɪts�?ɪd, �?skɪdz�?ɪd/, often abbreviated as SPD or SzPD) is a... more...

Related Diseases for Schizoid Personality Disorder

Diseases related to Schizoid Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 personality disorder 31.0 HTR1A HTR2A
2 alexithymia 10.1
3 dysthymic disorder 10.1 HTR2A PIR
4 phobic disorder 10.0 HTR1A PIR
5 agoraphobia 10.0 HTR1A PIR
6 hypoactive sexual desire disorder 10.0 HTR1A HTR2A
7 substance-induced psychosis 10.0 HTR1A HTR2A
8 psychosexual disorder 10.0 HTR1A HTR2A
9 periodic limb movement disorder 10.0 HTR1A HTR2A
10 drug-induced mental disorder 10.0 HTR1A HTR2A
11 drug psychosis 10.0 HTR1A HTR2A
12 borderline personality disorder 10.0 HTR1A HTR2A
13 serotonin syndrome 10.0 HTR1A HTR2A
14 bipolar i disorder 10.0 HTR1A HTR2A
15 mental depression 10.0 HTR1A HTR2A
16 depression 10.0 HTR1A HTR2A
17 endogenous depression 10.0 HTR1A HTR2A
18 generalized anxiety disorder 10.0 HTR1A HTR2A
19 histrionic personality disorder 10.0 MME PIR
20 anxiety 10.0 HTR1A HTR2A
21 chronic fatigue syndrome 10.0 HTR1A HTR2A
22 dependent personality disorder 10.0 MME PIR
23 disease of mental health 9.9 HTR1A HTR2A
24 mood disorder 9.9 HTR1A HTR2A
25 psychotic disorder 9.9 HTR1A HTR2A
26 panic disorder 9.9 HTR1A HTR2A
27 obsessive-compulsive disorder 9.9 HTR1A HTR2A
28 migraine with or without aura 1 9.9 HTR1A HTR2A
29 sudden infant death syndrome 9.9 HTR1A HTR2A
30 alcohol dependence 9.8 HTR1A HTR2A
31 major depressive disorder 9.8 HTR1A HTR2A

Comorbidity relations with Schizoid Personality Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Major Depressive Disorder
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Schizoid Personality Disorder:



Diseases related to Schizoid Personality Disorder

Symptoms & Phenotypes for Schizoid Personality Disorder

Drugs & Therapeutics for Schizoid Personality Disorder

Drugs for Schizoid Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Atomoxetine Hydrochloride Phase 3
2 Neurotransmitter Agents Phase 3
3 Neurotransmitter Uptake Inhibitors Phase 3
4 Adrenergic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Atomoxetine on Psychosocial Function of Children and Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD) Completed NCT00320528 Phase 3 atomoxetine
2 Essential Oils for Enhancing QOL in ASD Completed NCT02543203 Phase 2

Search NIH Clinical Center for Schizoid Personality Disorder

Cochrane evidence based reviews: schizoid personality disorder

Genetic Tests for Schizoid Personality Disorder

Anatomical Context for Schizoid Personality Disorder

Publications for Schizoid Personality Disorder

Articles related to Schizoid Personality Disorder:

(show all 12)
# Title Authors Year
1
Poor Validity of the DSM-IV Schizoid Personality Disorder Construct as a Diagnostic Category. ( 25248009 )
2014
2
Are alexithymia and schizoid personality disorder synonymous diagnoses? ( 23021894 )
2013
3
Schizoid Personality Disorder. ( 22928849 )
2012
4
Schizoid personality disorder. ( 23281676 )
2012
5
Failures of the 'moral defence' in the films Shutter Island, Inception and Memento: narcissism or schizoid personality disorder? ( 22320143 )
2012
6
"I am not complaining"--ambivalence construct in schizoid personality disorder. ( 19711768 )
2009
7
Does change in temperament predict change in schizoid personality disorder? A methodological framework and illustration from the Longitudinal Study of Personality Disorders. ( 19825265 )
2009
8
Assessing interpersonal aspects of schizoid personality disorder: preliminary validation studies. ( 18444113 )
2008
9
Low body weight in male children and adolescents with schizoid personality disorder or Asperger's disorder. ( 9259226 )
1997
10
Schizoid personality disorder after prenatal exposure to famine. ( 8942466 )
1996
11
Lifelong eccentricity and social isolation. II: Asperger's syndrome or schizoid personality disorder? ( 3256377 )
1988
12
Schizoid personality disorder: a synthesis of developmental, dynamic, and descriptive features. ( 3324773 )
1987

Variations for Schizoid Personality Disorder

Expression for Schizoid Personality Disorder

Search GEO for disease gene expression data for Schizoid Personality Disorder.

Pathways for Schizoid Personality Disorder

GO Terms for Schizoid Personality Disorder

Cellular components related to Schizoid Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 8.8 HTR1A HTR2A MME

Biological processes related to Schizoid Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.32 HTR1A HTR2A
2 sensory perception of pain GO:0019233 9.26 HTR2A MME
3 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.16 HTR1A HTR2A
4 behavior GO:0007610 8.96 HTR1A HTR2A
5 serotonin receptor signaling pathway GO:0007210 8.62 HTR1A HTR2A

Molecular functions related to Schizoid Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter receptor activity GO:0030594 9.16 HTR1A HTR2A
2 G protein-coupled serotonin receptor activity GO:0004993 8.96 HTR1A HTR2A
3 serotonin binding GO:0051378 8.62 HTR1A HTR2A

Sources for Schizoid Personality Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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