SCZD13
MCID: SCH053
MIFTS: 26

Schizophrenia 13 (SCZD13)

Categories: Ear diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Schizophrenia 13

MalaCards integrated aliases for Schizophrenia 13:

Name: Schizophrenia 13 57 12 29 15 70
Schizophrenia, Susceptibility to, 13 57 13
Sczd13 57 12
Schizophrenia Susceptibility Locus, Chromosome 15q13-Q14-Related 57

Classifications:



External Ids:

Disease Ontology 12 DOID:0070089
OMIM® 57 613025
MedGen 41 C2751663
UMLS 70 C2751663

Summaries for Schizophrenia 13

Disease Ontology : 12 A schizophrenia that has material basis in a mutation on chromosome 15q13.

MalaCards based summary : Schizophrenia 13, also known as schizophrenia, susceptibility to, 13, is related to schizophrenia and stromal dystrophy. An important gene associated with Schizophrenia 13 is SCZD13 (Schizophrenia 13), and among its related pathways/superpathways is mTOR signaling pathway (KEGG). Affiliated tissues include eye, thyroid and pituitary.

More information from OMIM: 613025

Related Diseases for Schizophrenia 13

Graphical network of the top 20 diseases related to Schizophrenia 13:



Diseases related to Schizophrenia 13

Symptoms & Phenotypes for Schizophrenia 13

Clinical features from OMIM®:

613025 (Updated 05-Apr-2021)

Drugs & Therapeutics for Schizophrenia 13

Search Clinical Trials , NIH Clinical Center for Schizophrenia 13

Genetic Tests for Schizophrenia 13

Genetic tests related to Schizophrenia 13:

# Genetic test Affiliating Genes
1 Schizophrenia 13 29

Anatomical Context for Schizophrenia 13

MalaCards organs/tissues related to Schizophrenia 13:

40
Eye, Thyroid, Pituitary

Publications for Schizophrenia 13

Articles related to Schizophrenia 13:

(show top 50) (show all 53)
# Title Authors PMID Year
1
Population analysis of large copy number variants and hotspots of human genetic disease. 57
19166990 2009
2
Large recurrent microdeletions associated with schizophrenia. 57
18668039 2008
3
Rare chromosomal deletions and duplications increase risk of schizophrenia. 57
18668038 2008
4
Genetics of chromosome 15q13-q14 in schizophrenia. 57
16843094 2006
5
Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7). 57
11424985 2001
6
Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. 57
9012828 1997
7
Dopaminergic, Noradrenergic, Adrenal, and Thyroid Abnormalities in Psychotic and Affective Disorders. 61
33101075 2020
8
Basic self-disturbances are associated with Sense of Coherence in patients with psychotic disorders. 61
32294097 2020
9
Adjunctive minocycline for major mental disorders: A systematic review. 61
31294649 2019
10
Negative voice-content as a full mediator of a relation between childhood adversity and distress ensuing from hearing voices. 61
29580740 2018
11
Fast sleep spindle reduction in schizophrenia and healthy first-degree relatives: association with impaired cognitive function and potential intermediate phenotype. 61
27565806 2017
12
Is it relevant to screen young women hospitalized in psychiatric department for neuropsychiatric systemic lupus erythematosus (NPSLE)?: A prospective study of 100 psychiatric inpatients. 61
27893665 2016
13
Comparative neuropsychiatry: white matter abnormalities in children and adolescents with schizophrenia, bipolar affective disorder, and obsessive-compulsive disorder. 61
25498242 2015
14
Neurocognitive similarities between severe chronic schizophrenia and behavioural variant frontotemporal dementia. 61
25510904 2015
15
Health and use of health services of people who are homeless and at risk of homelessness who receive free primary health care in Dublin. 61
25884629 2015
16
Preserved priming effect in individuals with schizophrenia: cues towards rehabilitation. 61
26512433 2015
17
High aerobic intensity training and psychological States in patients with depression or schizophrenia. 61
25400592 2014
18
Functional MRI of sentence-level language comprehension in schizophrenia: a coordinate-based analysis. 61
23911258 2013
19
Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001-2007: a population-based study of 585,615 deliveries. 61
23389622 2013
20
Abnormal contextual modulation of visual contour detection in patients with schizophrenia. 61
23922637 2013
21
Overlapping and segregating structural brain abnormalities in twins with schizophrenia or bipolar disorder. 61
22474104 2012
22
A follow-up MRI study of the fusiform gyrus and middle and inferior temporal gyri in schizophrenia spectrum. 61
21820482 2011
23
Multivoxel proton MR spectroscopy used to distinguish anterior cingulate metabolic abnormalities in patients with schizophrenia. 61
21900615 2011
24
Factors associated with medication adherence among psychiatric outpatients at substance abuse risk. 61
23264842 2011
25
Longitudinal volume changes of the pituitary gland in patients with schizotypal disorder and first-episode schizophrenia. 61
21044655 2011
26
A follow-up MRI study of the superior temporal subregions in schizotypal disorder and first-episode schizophrenia. 61
20051316 2010
27
Substance Use and Mental Health Outcomes for Comorbid Patients in Psychiatric Day Treatment. 61
20333262 2009
28
An audit of new long-stay patients in Irish psychiatric inpatient services. 61
30282308 2009
29
Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophrenia. 61
19054502 2009
30
Physiogenomic analysis of localized FMRI brain activity in schizophrenia. 61
18330705 2008
31
Fronto-limbic and autonomic disjunctions to negative emotion distinguish schizophrenia subtypes. 61
17398080 2007
32
Progressive and interrelated functional and structural evidence of post-onset brain reduction in schizophrenia. 61
17485604 2007
33
[Effects of risperidone on polysomnography in patients with first-episode schizophrenia]. 61
17156674 2006
34
Preferences for schizophrenia treatment outcomes among public policy makers, consumers, families, and providers. 61
12883140 2003
35
Increased prevalence of type 2 diabetes mellitus among psychiatric inpatients with bipolar I affective and schizoaffective disorders independent of psychotropic drug use. 61
12113916 2002
36
Estimated neuronal populations and volumes of the hippocampus and its subfields in schizophrenia. 61
11986137 2002
37
Deficits in auditory and visual context-dependent processing in schizophrenia: defining the pattern. 61
11115326 2000
38
Shape and size of the corpus callosum in schizophrenia and schizotypal personality disorder. 61
10785578 2000
39
Diagnostic efficiency of the Rorschach schizophrenia and depression indices in identifying first-episode schizophrenia and severe depression 61
10579551 1999
40
EEG differences in monozygotic twins discordant and concordant for schizophrenia. 61
10098386 1999
41
Neurodevelopmental Pathways in Schizophrenia. 61
10085218 1998
42
Neuroendocrine responsivity to clomipramine challenge test in neuroleptic naive psychotic patients before and after treatment with haloperidol. 61
19698552 1997
43
A survey of sentenced prisoners transferred to hospital for urgent psychiatric treatment over a three-year period in one region. 61
9029919 1997
44
Prenatal growth markers in schizophrenia: a monozygotic co-twin control study. 61
8780420 1996
45
Effects of modality shift and motor response shift on simple reaction time in schizophrenia patients. 61
8772017 1996
46
Brain anatomic magnetic resonance imaging in childhood-onset schizophrenia. 61
8660128 1996
47
Mental health service use by the elderly in nursing homes. 61
8438968 1993
48
Extrapyramidal motor abnormalities associated with late-life psychosis. 61
7905662 1993
49
Detection of anti-cerebral autoantibodies in schizophrenia and Alzheimer's disease. 61
2657070 1989
50
[Disorders of repair processes in the lymphocytes of schizophrenia patients, cultured in vitro]. 61
3109521 1987

Variations for Schizophrenia 13

Expression for Schizophrenia 13

Search GEO for disease gene expression data for Schizophrenia 13.

Pathways for Schizophrenia 13

Pathways related to Schizophrenia 13 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.27 NPRL3 NPRL2 DEPDC5

GO Terms for Schizophrenia 13

Cellular components related to Schizophrenia 13 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 9.43 TPPP MOBP DEPDC5
2 lysosome GO:0005764 9.33 NPRL3 NPRL2 DEPDC5
3 lysosomal membrane GO:0005765 9.13 NPRL3 NPRL2 DEPDC5
4 GATOR1 complex GO:1990130 8.8 NPRL3 NPRL2 DEPDC5

Biological processes related to Schizophrenia 13 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of GTPase activity GO:0043547 9.43 NPRL3 NPRL2 DEPDC5
2 regulation of autophagosome assembly GO:2000785 9.16 NPRL3 NPRL2
3 cellular response to amino acid starvation GO:0034198 9.13 NPRL3 NPRL2 DEPDC5
4 negative regulation of TOR signaling GO:0032007 8.8 NPRL3 NPRL2 DEPDC5

Molecular functions related to Schizophrenia 13 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTPase activator activity GO:0005096 8.8 NPRL3 NPRL2 DEPDC5

Sources for Schizophrenia 13

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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