MCID: SCH052
MIFTS: 28

Schizophrenia 14

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Schizophrenia 14

MalaCards integrated aliases for Schizophrenia 14:

Name: Schizophrenia 14 56 12 15 71
Schizophrenia, Susceptibility to, 14 56 13
Sczd14 56 12
Schizophrenia Susceptibility Locus, Chromosome 2q32-Related 56

Classifications:



External Ids:

Disease Ontology 12 DOID:0070090
OMIM 56 612361
MedGen 41 C2677614
UMLS 71 C2677614

Summaries for Schizophrenia 14

Disease Ontology : 12 A schizophrenia that has material basis in a mutation on chromosome 2q32.1.

MalaCards based summary : Schizophrenia 14, also known as schizophrenia, susceptibility to, 14, is related to schizophrenia and schizophrenia 16. An important gene associated with Schizophrenia 14 is SCZD14 (Schizophrenia, Susceptibility To, 14), and among its related pathways/superpathways are Apoptosis Pathway and MAPK Signaling: Mitogen Stimulation Pathway. Affiliated tissues include brain, testes and cortex, and related phenotype is Increased human cytomegalovirus (HCMV) strain AD169 replication.

More information from OMIM: 612361

Related Diseases for Schizophrenia 14

Symptoms & Phenotypes for Schizophrenia 14

Clinical features from OMIM:

612361

GenomeRNAi Phenotypes related to Schizophrenia 14 according to GeneCards Suite gene sharing:

26 (showing 1, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 8.8 FGFR1 INSRR MAPK14

Drugs & Therapeutics for Schizophrenia 14

Search Clinical Trials , NIH Clinical Center for Schizophrenia 14

Genetic Tests for Schizophrenia 14

Anatomical Context for Schizophrenia 14

MalaCards organs/tissues related to Schizophrenia 14:

40
Brain, Testes, Cortex, Prefrontal Cortex, Temporal Lobe

Publications for Schizophrenia 14

Articles related to Schizophrenia 14:

(showing 42, show less)
# Title Authors PMID Year
1
Neural mechanisms of a genome-wide supported psychosis variant. 56
19407193 2009
2
Identification of loci associated with schizophrenia by genome-wide association and follow-up. 56
18677311 2008
3
Progressive brain structural changes after the first year of treatment in first-episode treatment-naive patients with deficit or nondeficit schizophrenia. 61
31059954 2019
4
Mortality trends in external causes of death in people with mental health disorders in Sweden, 1987-2010. 61
29493432 2019
5
Cortical stress regulation is disrupted in schizophrenia but not in clinical high risk for psychosis. 61
29860329 2018
6
Abnormal functional connectivity of high-frequency rhythms in drug-naïve schizophrenia. 61
29202390 2018
7
A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia. 61
29049482 2017
8
Disturbances of Agency and Ownership in Schizophrenia: An Auditory Verbal Event Related Potentials Study. 61
27209172 2016
9
Different outcomes of never-treated and treated patients with schizophrenia: 14-year follow-up study in rural China. 61
26382951 2015
10
Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives. 61
26594623 2015
11
Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia. 61
22137736 2012
12
Delusions and metacognition in patients with schizophrenia. 61
22216943 2012
13
Immunohistochemical study of vesicle monoamine transporter 2 in the hippocampal region of genetic animal model of schizophrenia. 61
20815037 2010
14
Slow wave sleep deficits as a trait marker in patients with schizophrenia. 61
20826077 2010
15
Hippocampal function in schizophrenia and bipolar disorder. 61
19732478 2010
16
Regional dopamine synthesis in patients with schizophrenia using L-[beta-11C]DOPA PET. 61
19056247 2009
17
Altered metabolic integrity of corpus callosum among individuals at ultra high risk of schizophrenia and first-episode patients. 61
18486106 2008
18
Gray matter volume differences and the effects of smoking on gray matter in schizophrenia. 61
17890058 2007
19
Volumetric analysis of septal region in schizophrenia and affective disorder. 61
17180571 2007
20
Spatial working memory as a cognitive endophenotype of schizophrenia: assessing risk for pathophysiological dysfunction. 61
16687386 2006
21
[The effects of a recovery education program on rehabilitation motivation, symptoms, and function for schizophrenic patients]. 61
16825838 2006
22
Spatial working memory and planning ability: contrasts between schizophrenia and bipolar I disorder. 61
16350658 2005
23
Auditory P300 in high-risk, recent-onset and chronic schizophrenia. 61
15944141 2005
24
The Canadian Psychiatric Association practice profile survey: II. General description of results. 61
12776391 2003
25
[Retrospective analysis of permanent disability among retired workers at Universidade Federal de Minas Gerais from 1966 to 1999]. 61
12724814 2003
26
Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation. 61
11926935 2002
27
[Dynamic paradigm in psychopathology: "chaos theory", from physics to psychiatry]. 61
11488256 2001
28
Olfactory dysfunction in schizophrenia and temporal lobe epilepsy. 61
11417670 2001
29
Early onset psychotic disorders: diagnostic stability and clinical characteristics. 61
10546979 1999
30
Temporal horn enlargement is present in schizophrenia and bipolar disorder. 61
9777171 1998
31
Perceptual organization in schizophrenia: utilization of the Gestalt principles. 61
9358683 1997
32
Deficits in multiple systems of working memory in schizophrenia. 61
9373889 1997
33
Maternal representations of patients with schizophrenia as measured by the Parental Bonding Instrument. 61
9104102 1997
34
Glial fibrillary acidic protein-immunoreactive astrocytosis in elderly patients with schizophrenia and dementia. 61
8834539 1996
35
The correlates of cortical sulci atrophy and central atrophy in a cohort of schizophrenia and manic subjects in Nigeria. 61
7621389 1995
36
Communication deficits in childhood schizophrenia spectrum disorders. 61
7701275 1994
37
First-contact rate for schizophrenia in community psychiatric care. Consideration of the oestrogen hypothesis. 61
8323983 1993
38
Paranoid disorders following war brain damage. Preliminary report. 61
1784707 1991
39
[Thyrotrophin-releasing hormone (TRH) stimulation test in psychiatric patients]. 61
2118064 1990
40
Mental disorder in youth suicide. DSM-III-R Axes I and II. 61
2750550 1989
41
[Changes in various indices of the blood-clotting system and lipid levels in patients with depression]. 61
3591138 1987
42
[Sex gland morphology of schizophrenic patients during treatment with psychotropic drugs]. 61
19906 1977

Variations for Schizophrenia 14

Expression for Schizophrenia 14

Search GEO for disease gene expression data for Schizophrenia 14.

Pathways for Schizophrenia 14

Pathways related to Schizophrenia 14 according to GeneCards Suite gene sharing:

(showing 8, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.75 YWHAH MAPK14 FGFR1
2
Show member pathways
11.68 YWHAH INSRR FGFR1
3
Show member pathways
11.58 YWHAH MAPK14
4 11.11 YWHAH MAPK14
5 11.06 MAPK14 FGFR1
6
Show member pathways
10.91 YWHAH MAPK14
7 10.56 YWHAH MAPK14
8 9.92 YWHAH MAPK14

GO Terms for Schizophrenia 14

Biological processes related to Schizophrenia 14 according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of blood vessel endothelial cell migration GO:0043536 9.16 MAPK14 FGFR1
2 chondrocyte differentiation GO:0002062 8.96 MAPK14 FGFR1
3 positive regulation of cardiac muscle cell proliferation GO:0060045 8.62 MAPK14 FGFR1

Molecular functions related to Schizophrenia 14 according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 INSRR FGFR1

Sources for Schizophrenia 14

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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