SCZD18
MCID: SCH087
MIFTS: 28

Schizophrenia 18 (SCZD18)

Categories: Ear diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Schizophrenia 18

MalaCards integrated aliases for Schizophrenia 18:

Name: Schizophrenia 18 57 12 72 29 6 15 70
Sczd18 57 12 72
Schizophrenia 18 with or Without an Affective Disorder 57 72
Schizophrenia Susceptibility 18 57 13
Chromosome 7q36.3 Duplication Syndrome, 362-Kb 12
Schizophrenia, Type 18 39

Classifications:



External Ids:

Disease Ontology 12 DOID:0070093
OMIM® 57 615232
MeSH 44 D012559
UMLS 70 C3808913

Summaries for Schizophrenia 18

UniProtKB/Swiss-Prot : 72 Schizophrenia 18: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.

MalaCards based summary : Schizophrenia 18, also known as sczd18, is related to schizophrenia 16 and aminoaciduria. An important gene associated with Schizophrenia 18 is SLC1A1 (Solute Carrier Family 1 Member 1). Affiliated tissues include brain, cortex and skin.

Disease Ontology : 12 A schizophrenia that has material basis in a mutation of SLC1A1 on chromosome 9p24.2.

More information from OMIM: 615232

Related Diseases for Schizophrenia 18

Diseases in the Schizophrenia family:

Schizophrenia 1 Schizophrenia 3
Schizophrenia 4 Schizophrenia 6
Schizophrenia 5 Schizophrenia 7
Schizophrenia 8 Schizophrenia 2
Schizophrenia 9 Schizophrenia 10
Schizophrenia 11 Schizophrenia 12
Schizophrenia 14 Schizophrenia 13
Schizophrenia 15 Schizophrenia 16
Schizophrenia 18 Schizophrenia 19
Early-Onset Schizophrenia

Diseases related to Schizophrenia 18 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 16 11.6
2 aminoaciduria 10.1 SPATA6L SLC1A1
3 learning disability 10.0 PRODH NPAS3
4 dicarboxylic aminoaciduria 9.9 SPATA6L SLC1A1 PRODH
5 echolalia 9.8 PRODH NRXN1
6 schizophreniform disorder 9.8 PRODH NRXN1
7 potocki-lupski syndrome 9.8 PRODH NRXN1
8 schizophrenia 9 9.8 PRODH NPAS3 FCSK
9 schizophrenia 15 9.8 PRODH NPAS3 FCSK
10 speech disorder 9.8 PRODH NRXN1
11 parkinsonism 9.8
12 chromosomal deletion syndrome 9.8 PRODH NRXN1
13 velocardiofacial syndrome 9.7 PRODH NRXN1
14 schizophrenia 2 9.7 PRODH LRRTM4 FCSK
15 chromosomal disease 9.7 PRODH NRXN1
16 tic disorder 9.7 SLC1A1 PRODH NRXN1
17 schizoaffective disorder 9.7 SLC1A1 PRODH NRXN1
18 psychotic disorder 9.7 SLC1A1 PRODH NRXN1
19 specific developmental disorder 9.6 PRODH NRXN1
20 pervasive developmental disorder 9.5 PRODH NRXN1
21 schizophrenia 9.5 SLC1A1 PRODH NRXN1 NPAS3
22 bipolar disorder 9.4 SLC1A1 PRODH NRXN1 NPAS3
23 autism 9.4 SLC1A1 PRODH NRXN1 NPAS3
24 autism spectrum disorder 9.4 SLC1A1 PRODH NRXN1 NPAS3
25 schizophrenia 4 9.3 SLC1A1 PRODH NPAS3 LRRTM4 FCSK

Graphical network of the top 20 diseases related to Schizophrenia 18:



Diseases related to Schizophrenia 18

Symptoms & Phenotypes for Schizophrenia 18

Clinical features from OMIM®:

615232 (Updated 05-Apr-2021)

Drugs & Therapeutics for Schizophrenia 18

Search Clinical Trials , NIH Clinical Center for Schizophrenia 18

Genetic Tests for Schizophrenia 18

Genetic tests related to Schizophrenia 18:

# Genetic test Affiliating Genes
1 Schizophrenia 18 29 SLC1A1

Anatomical Context for Schizophrenia 18

MalaCards organs/tissues related to Schizophrenia 18:

40
Brain, Cortex, Skin, Cingulate Cortex

Publications for Schizophrenia 18

Articles related to Schizophrenia 18:

(show all 40)
# Title Authors PMID Year
1
Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family. 57 6
23341099 2013
2
Copy number variants for schizophrenia and related psychotic disorders in Oceanic Palau: risk and transmission in extended pedigrees. 57
21982423 2011
3
Atypical response inhibition and error processing in 22q11.2 Deletion Syndrome and schizophrenia: Towards neuromarkers of disease progression and risk. 61
32731196 2020
4
Assessing the potential of longitudinal smartphone based cognitive assessment in schizophrenia: A naturalistic pilot study. 61
31024801 2019
5
Advanced Paternal Age and Early Onset of Schizophrenia in Sporadic Cases: Not Confounded by Parental Polygenic Risk for Schizophrenia. 61
30926130 2019
6
Cerebrospinal fluid BDNF pro-peptide levels in major depressive disorder and schizophrenia. 61
30986693 2019
7
Inpatient Psychiatric Hospitalization in Texas 1999 to 2010. 61
31042801 2019
8
Improving the quality of life of people with schizophrenia through community based rehabilitation in Yogyakarta Province, Indonesia: A quasi experimental study. 61
30974306 2019
9
Working Memory in Patients with Schizophrenia and Bipolar Affective Disorder: Quantitative or Qualitative Differences? 61
30948690 2019
10
The effects of illness severity, cognition, and estimated antipsychotic dopamine receptor occupancy on insight into the illness in schizophrenia: An analysis of clinical antipsychotic trials of intervention effectiveness (CATIE) data. 61
30172739 2019
11
Occurrence of post-injection delirium/sedation syndrome after application of olanzapine long-acting injection during one year period. 61
29197208 2017
12
Decreased middle temporal gyrus connectivity in the language network in schizophrenia patients with auditory verbal hallucinations. 61
28572034 2017
13
The effect of brexpiprazole in adult outpatients with early-episode schizophrenia: an exploratory study. 61
27571460 2016
14
Diagnostic shift in patients diagnosed with schizoaffective disorder: a systematic review and meta-analysis of rediagnosis studies. 61
27226263 2016
15
Measurement of Bmax and Kd with the glycine transporter 1 radiotracer ¹⁸F-MK6577 using a novel multi-infusion paradigm. 61
26198176 2015
16
Schizotypy and personality profiles of Cluster A in a group of schizophrenic patients and their siblings. 61
24094118 2013
17
Processes of in-hospital psychiatric care and subsequent criminal behaviour among patients with schizophrenia: a national population-based, follow-up study. 61
24099499 2013
18
Neuroimaging evidence for the deficit subtype of schizophrenia. 61
23467781 2013
19
Facial emotion recognition in child psychiatry: a systematic review. 61
23475001 2013
20
Inefficient cerebral recruitment as a vulnerability marker for schizophrenia. 61
22578475 2013
21
Predicting the likelihood of suicide attempts for rural outpatients with schizophrenia. 61
22861353 2012
22
Impact of reversionary and other etiological factors on prognosis and course of schizophrenia. 61
21258311 2010
23
Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophrenia. 61
19884604 2009
24
Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders. 61
19736350 2009
25
Absent response to niacin skin patch is specific to schizophrenia and independent of smoking. 61
17459487 2007
26
Neural correlates of verbal and nonverbal working memory deficits in individuals with schizophrenia and their high-risk siblings. 61
16842976 2006
27
Effects of a mutual support group for families of Chinese people with schizophrenia: 18-month follow-up. 61
16816305 2006
28
"Bread madness" revisited: screening for specific celiac antibodies among schizophrenia patients. 61
15276666 2004
29
[Liaison psychiatry in two public hospitals of Santiago]. 61
15332374 2004
30
Cognitive-behavioural therapy in first-episode and early schizophrenia. 18-month follow-up of a randomised controlled trial. 61
14990521 2004
31
Application of a new image analysis technique to study brain asymmetry in schizophrenia. 61
14511793 2003
32
Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density. 61
12814860 2003
33
Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives. 61
12215084 2002
34
Spontaneous dyskinesia and parkinsonism in never-medicated, chronically ill patients with schizophrenia: 18-month follow-up. 61
12151284 2002
35
Neuropsychological deficit in siblings discordant for schizophrenia. 61
11087021 2000
36
Albumin decrement in depression and cholesterol decrement in mania. 61
2145338 1990
37
[Clinico-psychological correlations of mental rigidity in anorexia nervosa]. 61
1963009 1990
38
Do neuroleptics cause depression? 61
6145454 1984
39
Relationship between cerebrospinal fluid amine metabolites, neuroendocrine findings and personality dimensions (Marke-Nyman scale factors) in psychiatric patients. 61
6190356 1983
40
Psychiatric morbidity among university students in Egypt. 61
912216 1977

Variations for Schizophrenia 18

ClinVar genetic disease variations for Schizophrenia 18:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 SLC1A1 nsv1067898 Deletion Pathogenic 50362 GRCh37: 9:4406529-4490826
GRCh38: 9:4406529-4490826
2 SLC1A1 , SPATA6L NM_004170.6(SLC1A1):c.860C>G (p.Ala287Gly) SNV Likely benign 620038 GRCh37: 9:4573999-4573999
GRCh38: 9:4573999-4573999

Expression for Schizophrenia 18

Search GEO for disease gene expression data for Schizophrenia 18.

Pathways for Schizophrenia 18

GO Terms for Schizophrenia 18

Cellular components related to Schizophrenia 18 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 8.92 SORBS3 SLC1A1 NRXN1 LRRTM4

Biological processes related to Schizophrenia 18 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 establishment of protein localization GO:0045184 8.62 SLC1A1 NRXN1

Sources for Schizophrenia 18

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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