SCZD2
MCID: SCH085
MIFTS: 38

Schizophrenia 2 (SCZD2)

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Schizophrenia 2

MalaCards integrated aliases for Schizophrenia 2:

Name: Schizophrenia 2 58 12 76 15 74
Sczd2 58 12 76
Schizophrenia Susceptibility Locus, Chromosome 11q-Related 58
Schizophrenia Susceptibility Locus Chromosome 11q-Related 76

Classifications:



External Ids:

Disease Ontology 12 DOID:0070078
OMIM 58 603342
MeSH 45 D012559
MedGen 43 C1864010
UMLS 74 C1864010

Summaries for Schizophrenia 2

UniProtKB/Swiss-Prot : 76 Schizophrenia 2: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.

MalaCards based summary : Schizophrenia 2, also known as sczd2, is related to schizophrenia and perrault syndrome 1. An important gene associated with Schizophrenia 2 is SCZD2 (Schizophrenia Disorder 2), and among its related pathways/superpathways are MAPK signaling pathway and Ras signaling pathway. Related phenotypes are behavior/neurological and growth/size/body region

Disease Ontology : 12 A schizophrenia that has material basis in an autosomal dominant mutation of SCZD2 on chromosome 11q14-q21.

Description from OMIM: 603342

Related Diseases for Schizophrenia 2

Diseases in the Schizophrenia family:

Schizophrenia 1 Schizophrenia 3
Schizophrenia 4 Schizophrenia 6
Schizophrenia 5 Schizophrenia 7
Schizophrenia 8 Schizophrenia 2
Schizophrenia 9 Schizophrenia 10
Schizophrenia 11 Schizophrenia 12
Schizophrenia 14 Schizophrenia 13
Schizophrenia 15 Schizophrenia 16
Schizophrenia 18 Schizophrenia 19
Early-Onset Schizophrenia

Diseases related to Schizophrenia 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 29.4 BDNF CCKAR DISC1 DISC2 NTF3 SCZD2
2 perrault syndrome 1 11.1
3 hypochondriasis 10.2 NTF3 NTF4
4 diabetic autonomic neuropathy 10.1 NGF NTF3
5 diabetic polyneuropathy 10.1 NGF NTF3
6 simultanagnosia 10.0 APOE MFGE8
7 schizoaffective disorder 10.0 BDNF DISC1 DISC2
8 cannabis abuse 10.0 BDNF NGF
9 mood disorder 10.0 BDNF DISC1 DISC2
10 neuropathy, hereditary sensory and autonomic, type v 9.9 BDNF NGF
11 adult astrocytic tumour 9.9 BDNF NGF
12 senile plaque formation 9.9 APOE CHAT
13 head injury 9.9 APOE CHAT
14 paine syndrome 9.9 BDNF NGF
15 paranoid schizophrenia 9.9 BDNF CCKAR
16 tendinosis 9.9 BDNF CHAT
17 drug-induced hearing loss 9.8 BDNF HRK
18 hermansky-pudlak syndrome 3 9.8 APOE TYR
19 bipolar disorder 9.8 BDNF DISC1 DISC2 NTF3
20 traumatic brain injury 9.7 APOE BDNF
21 brain injury 9.7 APOE BDNF
22 amnestic disorder 9.7 BDNF CHAT
23 schizophrenia 1 9.7
24 major affective disorder 4 9.7
25 major affective disorder 8 9.7
26 major affective disorder 7 9.7
27 major affective disorder 9 9.7
28 disease of mental health 9.6 APOE BDNF DISC1
29 hydrocephalus 9.6 APOE NGF NTF3
30 ocular dominance 9.6 BDNF CHAT NGF NTF3
31 major depressive disorder 9.5 APOE BDNF DISC1 DISC2
32 schizophrenia 3 9.4 APOE HRK MFGE8 NGF
33 nervous system disease 9.3 APOE BDNF CHAT NGF
34 central nervous system disease 9.3 APOE BDNF CHAT NGF
35 parkinson disease, late-onset 9.3 APOE BDNF CHAT NGF

Graphical network of the top 20 diseases related to Schizophrenia 2:



Diseases related to Schizophrenia 2

Symptoms & Phenotypes for Schizophrenia 2

Clinical features from OMIM:

603342

MGI Mouse Phenotypes related to Schizophrenia 2:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 APOE BDNF CCKAR CHAT DISC1 NGF
2 growth/size/body region MP:0005378 10.13 APOE BDNF CCKAR CHAT DISC1 NGF
3 homeostasis/metabolism MP:0005376 10.06 APOE BDNF CCKAR CHAT DISC1 NGF
4 cardiovascular system MP:0005385 10 APOE CHAT MFGE8 NGF NTF3 TENM4
5 nervous system MP:0003631 9.96 APOE BDNF CCKAR CHAT DISC1 NGF
6 integument MP:0010771 9.85 APOE BDNF MFGE8 NGF NTF4 TYR
7 limbs/digits/tail MP:0005371 9.72 APOE CHAT NTF4 TENM4 TYR
8 reproductive system MP:0005389 9.7 APOE BDNF CHAT MFGE8 NTF3 NTF4
9 taste/olfaction MP:0005394 9.13 APOE BDNF CCKAR
10 vision/eye MP:0005391 9.1 APOE BDNF CHAT NGF NTF3 TYR

Drugs & Therapeutics for Schizophrenia 2

Search Clinical Trials , NIH Clinical Center for Schizophrenia 2

Genetic Tests for Schizophrenia 2

Anatomical Context for Schizophrenia 2

Publications for Schizophrenia 2

Articles related to Schizophrenia 2:

(show all 14)
# Title Authors Year
1
Exome Sequencing Identifies TENM4 as a Novel Candidate Gene for Schizophrenia in the SCZD2 Locus at 11q14-21. ( 30745909 )
2018
2
Effects of cognitive rehabilitation training on schizophrenia: 2 years of follow-up. ( 26629117 )
2015
3
Effects of a mindfulness-based psychoeducation programme for Chinese patients with schizophrenia: 2-year follow-up. ( 24809397 )
2014
4
Symptomatic remission in previously untreated patients with schizophrenia: 2-year results from the SOHO study. ( 17310386 )
2007
5
Prediction of medication noncompliance in outpatients with schizophrenia: 2-year follow-up study. ( 16318875 )
2006
6
Quality of life of patients with schizophrenia 2. ( 16761659 )
2005
7
Musical hallucinations in schizophrenia. 2. Relations with verbal hallucinations. ( 12766321 )
2003
8
Natural course of schizophrenia: 2-year follow-up study in a rural Chinese community. ( 11157428 )
2001
9
Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder. ( 11525420 )
2001
10
Invited commentary on: Natural course of schizophrenia: 2-year follow-up study in a rural Chinese community. ( 11157429 )
2001
11
Environmental interventions in schizophrenia. 2: The community level. ( 10495650 )
1999
12
Motor, volitional and behavioural disorders in schizophrenia. 2: The 'conflict of paradigms' hypothesis. ( 2036530 )
1991
13
Schizophrenia. 2. Psycho-analytical and other opinions. ( 1121434 )
1975
14
Elementary psychiatry; schizophrenia. 2. ( 5245241 )
1968

Variations for Schizophrenia 2

Expression for Schizophrenia 2

Search GEO for disease gene expression data for Schizophrenia 2.

Pathways for Schizophrenia 2

Pathways related to Schizophrenia 2 according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1 12.5 BDNF NGF NTF3 NTF4
2
Show member pathways
12.45 BDNF NGF NTF3 NTF4
3
Show member pathways
12.43 BDNF NGF NTF3 NTF4
4
Show member pathways
12.38 BDNF NGF NTF3 NTF4
5
Show member pathways
12.29 BDNF NGF NTF3 NTF4
6
Show member pathways
12.15 BDNF NGF NTF3 NTF4
7 11.91 BDNF CHAT NGF
8
Show member pathways
11.88 BDNF NGF NTF3 NTF4
9 11.81 BDNF NGF NTF3
10
Show member pathways
11.72 BDNF NGF NTF3 NTF4
11 11.31 BDNF NGF NTF3 NTF4
12
Show member pathways
11.28 BDNF NGF NTF3 NTF4
13 11.09 BDNF NGF NTF3
14
Show member pathways
11.04 BDNF NGF NTF3 NTF4
15 10.92 BDNF CHAT NGF NTF3 NTF4
16 10.76 BDNF NGF NTF3 NTF4

GO Terms for Schizophrenia 2

Cellular components related to Schizophrenia 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 APOE BDNF MFGE8 NGF NTF3 NTF4
2 axon GO:0030424 9.46 BDNF NGF NTF3 NTF4
3 dendrite GO:0030425 9.35 APOE BDNF NGF NTF3 NTF4
4 synaptic vesicle GO:0008021 8.92 BDNF NGF NTF3 NTF4

Biological processes related to Schizophrenia 2 according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.81 BDNF NGF NTF3 NTF4
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.78 BDNF NGF NTF3 NTF4
3 memory GO:0007613 9.73 BDNF NGF NTF3 NTF4
4 negative regulation of neuron apoptotic process GO:0043524 9.72 APOE BDNF NGF NTF3 NTF4
5 neuron projection morphogenesis GO:0048812 9.71 BDNF NGF NTF3 NTF4
6 modulation of chemical synaptic transmission GO:0050804 9.67 BDNF NGF NTF3 NTF4
7 neurotrophin TRK receptor signaling pathway GO:0048011 9.63 BDNF NGF NTF4
8 peripheral nervous system development GO:0007422 9.56 BDNF NGF NTF3 NTF4
9 long-term memory GO:0007616 9.54 APOE NTF4
10 activation of phospholipase C activity GO:0007202 9.52 BDNF NTF4
11 positive regulation of collateral sprouting GO:0048672 9.49 BDNF NGF
12 regulation of neuron differentiation GO:0045664 9.46 BDNF NGF NTF3 NTF4
13 nerve development GO:0021675 9.26 BDNF NGF NTF3 NTF4
14 nerve growth factor signaling pathway GO:0038180 8.92 BDNF NGF NTF3 NTF4

Molecular functions related to Schizophrenia 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.92 BDNF NGF NTF3 NTF4

Sources for Schizophrenia 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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