SCZD3
MCID: SCH080
MIFTS: 31

Schizophrenia 3 (SCZD3)

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Schizophrenia 3

MalaCards integrated aliases for Schizophrenia 3:

Name: Schizophrenia 3 57 12 15 73
Schizophrenia Susceptibility Locus, Chromosome 6-Related 57 13
Sczd3 57 12
Schizophrenia 3 with or Without an Affective Disorder 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant susceptibility (6p23)


Classifications:



External Ids:

OMIM 57 600511
Disease Ontology 12 DOID:0070079
MedGen 42 C1838069
SNOMED-CT via HPO 69 88425004 191526005 58214004
UMLS 73 C1838069

Summaries for Schizophrenia 3

Disease Ontology : 12 A schizophrenia that has material basis in an autosomal dominant mutation of SCZD3 on chromosome 6p23.

MalaCards based summary : Schizophrenia 3, also known as schizophrenia susceptibility locus, chromosome 6-related, is related to perrault syndrome 1 and schizophrenia. An important gene associated with Schizophrenia 3 is SCZD3 (Schizophrenia Disorder 3), and among its related pathways/superpathways is NGF Pathway. The drugs Rimonabant and Hormones have been mentioned in the context of this disorder. Related phenotypes are schizophrenia and abnormality of the nervous system

Description from OMIM: 600511

Related Diseases for Schizophrenia 3

Graphical network of the top 20 diseases related to Schizophrenia 3:



Diseases related to Schizophrenia 3

Symptoms & Phenotypes for Schizophrenia 3

Symptoms via clinical synopsis from OMIM:

57
Neuro:
schizophrenia


Clinical features from OMIM:

600511

Human phenotypes related to Schizophrenia 3:

32
# Description HPO Frequency HPO Source Accession
1 schizophrenia 32 HP:0100753
2 abnormality of the nervous system 32 HP:0000707

MGI Mouse Phenotypes related to Schizophrenia 3:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.62 APOE SLC6A1

Drugs & Therapeutics for Schizophrenia 3

Drugs for Schizophrenia 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rimonabant Approved, Investigational Phase 2 158681-13-1, 168273-06-1 104850
2 Hormones Phase 2
3 Cannabinoid Receptor Antagonists Phase 2
4 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
5 Hormone Antagonists Phase 2
6 Neurotransmitter Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effects of Rimonabant, on Weight and Metabolic Risk Factors Terminated NCT00547118 Phase 2 Rimonabant;Placebo

Search NIH Clinical Center for Schizophrenia 3

Genetic Tests for Schizophrenia 3

Anatomical Context for Schizophrenia 3

Publications for Schizophrenia 3

Articles related to Schizophrenia 3:

# Title Authors Year
1
Chilaiditi syndrome--associated schizophrenia: 3 case reports. ( 11235932 )
2001
2
Neurosis and schizophrenia. 3. Clinical considerations. ( 5965200 )
1966

Variations for Schizophrenia 3

Expression for Schizophrenia 3

Search GEO for disease gene expression data for Schizophrenia 3.

Pathways for Schizophrenia 3

Pathways related to Schizophrenia 3 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.81 HRK NGF

GO Terms for Schizophrenia 3

Cellular components related to Schizophrenia 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular vesicle GO:1903561 8.62 APOE MFGE8

Biological processes related to Schizophrenia 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 8.62 APOE NGF

Sources for Schizophrenia 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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