SCZD5
MCID: SCH082
MIFTS: 33

Schizophrenia 5 (SCZD5)

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Schizophrenia 5

MalaCards integrated aliases for Schizophrenia 5:

Name: Schizophrenia 5 57 12 15 73
Schizophrenia Susceptibility Locus, Chromosome 6q-Related 57 13
Sczd5 57 12
Schizophrenia 5 with or Without an Affective Disorder 57

Classifications:



External Ids:

OMIM 57 603175
Disease Ontology 12 DOID:0070081
MedGen 42 C1864153
UMLS 73 C1864153

Summaries for Schizophrenia 5

Disease Ontology : 12 A schizophrenia that has material basis in a mutation on chromosome 6q13-q26.

MalaCards based summary : Schizophrenia 5, also known as schizophrenia susceptibility locus, chromosome 6q-related, is related to schizophrenia and personality disorder. An important gene associated with Schizophrenia 5 is SCZD5 (Schizophrenia Disorder 5), and among its related pathways/superpathways are Neuroscience and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include brain.

Description from OMIM: 603175

Related Diseases for Schizophrenia 5

Graphical network of the top 20 diseases related to Schizophrenia 5:



Diseases related to Schizophrenia 5

Symptoms & Phenotypes for Schizophrenia 5

Clinical features from OMIM:

603175

Drugs & Therapeutics for Schizophrenia 5

Search Clinical Trials , NIH Clinical Center for Schizophrenia 5

Genetic Tests for Schizophrenia 5

Anatomical Context for Schizophrenia 5

MalaCards organs/tissues related to Schizophrenia 5:

41
Brain

Publications for Schizophrenia 5

Articles related to Schizophrenia 5:

# Title Authors Year
1
Renaming schizophrenia: 5 × 5. ( 30334509 )
2018

Variations for Schizophrenia 5

Expression for Schizophrenia 5

Search GEO for disease gene expression data for Schizophrenia 5.

Pathways for Schizophrenia 5

GO Terms for Schizophrenia 5

Cellular components related to Schizophrenia 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.62 HTR2A MAP2 MAPT PRKAA2
2 axon GO:0030424 9.56 COMT HTR2A MAPT PRKAA2
3 dendritic shaft GO:0043198 9.4 HTR2A MAP2
4 nuclear periphery GO:0034399 9.37 MAP2 MAPT
5 cell body GO:0044297 9.33 COMT MAP2 MAPT
6 dendrite GO:0030425 9.1 COMT HTR2A HTR6 MAP2 MAPT PRKAA2
7 main axon GO:0044304 8.96 MAP2 MAPT

Biological processes related to Schizophrenia 5 according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of autophagy GO:0010506 9.51 EP300 MAPT
2 response to estrogen GO:0043627 9.49 COMT EP300
3 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.48 HTR2A HTR6
4 regulation of cellular response to heat GO:1900034 9.46 EP300 MAPT
5 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.43 HTR2A HTR6
6 regulation of microtubule cytoskeleton organization GO:0070507 9.4 MAPT PRKAA2
7 positive regulation of glycolytic process GO:0045821 9.37 HTR2A PRKAA2
8 central nervous system neuron development GO:0021954 9.32 MAP2 MAPT
9 regulation of microtubule polymerization GO:0031113 9.26 MAP2 MAPT
10 positive regulation of cellular protein localization GO:1903829 9.16 MAPT PRKAA2
11 internal protein amino acid acetylation GO:0006475 8.96 EP300 MAPT
12 negative regulation of tubulin deacetylation GO:1904428 8.62 MAPT PRKAA2

Molecular functions related to Schizophrenia 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tubulin binding GO:0015631 9.16 MAP2 MAPT
2 neurotransmitter receptor activity GO:0030594 8.96 HTR2A HTR6
3 G protein-coupled serotonin receptor activity GO:0004993 8.62 HTR2A HTR6

Sources for Schizophrenia 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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