SCZD5
MCID: SCH082
MIFTS: 23

Schizophrenia 5 (SCZD5)

Categories: Ear diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Schizophrenia 5

MalaCards integrated aliases for Schizophrenia 5:

Name: Schizophrenia 5 57 12 15 70
Schizophrenia Susceptibility Locus, Chromosome 6q-Related 57 13
Sczd5 57 12
Schizophrenia 5 with or Without an Affective Disorder 57

Classifications:



External Ids:

Disease Ontology 12 DOID:0070081
OMIM® 57 603175
MedGen 41 C1864153
UMLS 70 C1864153

Summaries for Schizophrenia 5

Disease Ontology : 12 A schizophrenia that has material basis in a mutation on chromosome 6q13-q26.

MalaCards based summary : Schizophrenia 5, also known as schizophrenia susceptibility locus, chromosome 6q-related, is related to schizophrenia and autism spectrum disorder. An important gene associated with Schizophrenia 5 is TAAR6 (Trace Amine Associated Receptor 6), and among its related pathways/superpathways are GABAergic synapse and G alpha (s) signalling events. Affiliated tissues include brain, cortex and prefrontal cortex.

More information from OMIM: 603175

Related Diseases for Schizophrenia 5

Symptoms & Phenotypes for Schizophrenia 5

Clinical features from OMIM®:

603175 (Updated 05-Apr-2021)

Drugs & Therapeutics for Schizophrenia 5

Search Clinical Trials , NIH Clinical Center for Schizophrenia 5

Genetic Tests for Schizophrenia 5

Anatomical Context for Schizophrenia 5

MalaCards organs/tissues related to Schizophrenia 5:

40
Brain, Cortex, Prefrontal Cortex, Cerebellum

Publications for Schizophrenia 5

Articles related to Schizophrenia 5:

(show top 50) (show all 67)
# Title Authors PMID Year
1
Fine mapping of a schizophrenia susceptibility locus at chromosome 6q23: increased evidence for linkage and reduced linkage interval. 57
15812564 2005
2
Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia. 57
15329799 2004
3
Genome scan of Arab Israeli families maps a schizophrenia susceptibility gene to chromosome 6q23 and supports a locus at chromosome 10q24. 57
12808429 2003
4
A schizophrenia-susceptibility locus at 6q25, in one of the world's largest reported pedigrees. 57
11389481 2001
5
Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees. 57
9226366 1997
6
Association of Follow-Up After an Emergency Department Visit for Mental Illness with Utilization Based Outcomes. 61
33438094 2021
7
SZDB2.0: an updated comprehensive resource for schizophrenia research. 61
32385526 2020
8
Targeting Serotonin 5-HT2A Receptors to Better Treat Schizophrenia: Rationale and Current Approaches. 61
32783116 2020
9
Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders. 61
32398722 2020
10
Comprehensive review of the research employing the schizophrenia cognition rating scale (SCoRS). 61
31196736 2019
11
Renaming schizophrenia: 5 × 5. 61
30334509 2019
12
Patients with Schizophrenia Do Not Demonstrate Worse Outcome After Sleeve Gastrectomy: a Short-Term Cohort Study. 61
30397877 2019
13
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update. 61
29767995 2018
14
Neurochemical changes underlying schizophrenia-related behavior in a modified forced swim test in mice. 61
29913190 2018
15
The Dopamine Allosteric Agent, PAOPA, Demonstrates Therapeutic Potential in the Phencyclidine NMDA Pre-clinical Rat Model of Schizophrenia. 61
30618660 2018
16
Paliperidone Palmitate Improves and Maintains Functioning in Asia-Pacific Patients with Schizophrenia. 61
29101715 2017
17
Guidelines for the Pharmacotherapy of Schizophrenia in Adults. 61
28703015 2017
18
AVN-322 is a Safe Orally Bio-Available Potent and Highly Selective Antagonist of 5-HT6R with Demonstrated Ability to Improve Impaired Memory in Animal Models. 61
27829340 2017
19
[Ultrastructural changes of myelinated fibers in the brain in continuous and attack-like paranoid schizophrenia]. 61
28374702 2017
20
What are the top 10 physical activity research questions in schizophrenia? 61
26728764 2016
21
Schizophrenia--time to commit to policy change. 61
24778411 2014
22
Medial prefrontal cortex: genes linked to bipolar disorder and schizophrenia have altered expression in the highly social maternal phenotype. 61
24765068 2014
23
Paliperidone palmitate versus oral risperidone and risperidone long-acting injection in patients with recently diagnosed schizophrenia: a tolerability and efficacy comparison. 61
24113628 2014
24
Neurocognitive functioning in patients with first-episode schizophrenia 1 year from onset in comparison with patients 5 years from onset. 61
24047425 2014
25
An EJC factor RBM8a regulates anxiety behaviors. 61
23638902 2013
26
Suicidal burn in Hong Kong. 61
22360959 2012
27
[Implication of 5-HT2A receptors in the genetic mechanisms of the brain 5-HT system autoregulation]. 61
22888631 2012
28
Self-experience in the early phases of schizophrenia: 5-year follow-up of the Copenhagen Prodromal Study. 61
21991279 2011
29
Serotonin 2A receptor antagonists for treatment of schizophrenia. 61
21740279 2011
30
[Clinical-genetic parameters and the nosological evaluation of schizoaffective psychosis in systematics of attack-like endogenous psychoses]. 61
21512496 2011
31
18F-fallypride binding potential in patients with schizophrenia compared to healthy controls. 61
20655709 2010
32
Regulation of serotonin receptor function in the nervous system by lipid rafts and adaptor proteins. 61
20211176 2010
33
Haplotype analysis confirms association of the serotonin transporter (5-HTT) gene with schizophrenia in the Han Chinese population. 61
19429037 2009
34
Delayed sympathetic hyperactivity following electroconvulsive therapy in patients with catatonic schizophrenia. 61
19562946 2009
35
The acute efficacy of aripiprazole across the symptom spectrum of schizophrenia: a pooled post hoc analysis from 5 short-term studies. 61
19192472 2009
36
Recovery as perceived by people with schizophrenia, family members and health professionals: a grounded theory. 61
17888440 2008
37
Needs-based cognitive-behavioural family intervention for patients suffering from schizophrenia: 5-year follow-up of a randomized controlled effectiveness trial. 61
17961200 2007
38
Failure to find association between TRAR4 and schizophrenia in the Chinese Han population. 61
16075187 2006
39
The relationships among cognition, motivation, and emotion in schizophrenia: how much and how little we know. 61
16079388 2005
40
[Interdependencies between anxiety versus premorbid and present self-image in patients with paranoid schizophrenia]. 61
15881627 2005
41
Effects on rat thalamic proteome by acute and subchronic MK-801-treatment. 61
15556142 2004
42
Clozapine increases both acetylcholine and dopamine release in rat ventral hippocampus: role of 5-HT1A receptor agonism. 61
15364019 2004
43
Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders. 61
15205874 2004
44
[Distribution of latencies of visual evoked potentials in a sample of schizophrenic patients]. 61
14727371 2003
45
Long-term outcome of late-onset schizophrenia: 5-year follow-up study. 61
12948993 2003
46
Endocannabinoid signalling in the blood of patients with schizophrenia. 61
12969514 2003
47
An RT-PCR study of 5-HT(6) and 5-HT(7) receptor mRNAs in the hippocampal formation and prefrontal cortex in schizophrenia. 61
12165372 2002
48
Expression of serotonin 5-HT(2A) receptors in the human cerebellum and alterations in schizophrenia. 61
11574947 2001
49
Plasma serotonin response to carbohydrate-rich food in chronic schizophrenic patients: clozapine versus classic antipsychotic agents. 61
12404560 2001
50
Oxidative stress and role of antioxidant and omega-3 essential fatty acid supplementation in schizophrenia. 61
11370992 2001

Variations for Schizophrenia 5

Expression for Schizophrenia 5

Search GEO for disease gene expression data for Schizophrenia 5.

Pathways for Schizophrenia 5

Pathways related to Schizophrenia 5 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.47 PDE4C NDUFA3
2 10.79 TAAR6 PDE4C

GO Terms for Schizophrenia 5

Sources for Schizophrenia 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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