SCZD6
MCID: SCH081
MIFTS: 27

Schizophrenia 6 (SCZD6)

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Schizophrenia 6

MalaCards integrated aliases for Schizophrenia 6:

Name: Schizophrenia 6 58 12 30 15 74
Schizophrenia Susceptibility Locus, Chromosome 8p-Related 58 13
Sczd6 58 12
Schizophrenia, Type 6 41

Classifications:



External Ids:

Disease Ontology 12 DOID:0070082
OMIM 58 603013
MedGen 43 C1864275
UMLS 74 C1864275

Summaries for Schizophrenia 6

Disease Ontology : 12 A schizophrenia that has material basis in an autosomal dominant mutation of SCZD6 on chromosome 8p21.

MalaCards based summary : Schizophrenia 6, also known as schizophrenia susceptibility locus, chromosome 8p-related, is related to schizophrenia and cone-rod dystrophy and hearing loss 2. An important gene associated with Schizophrenia 6 is NRG1 (Neuregulin 1), and among its related pathways/superpathways are Glioma and NF-KappaB Family Pathway. The drugs Rimonabant and Anti-Obesity Agents have been mentioned in the context of this disorder.

Description from OMIM: 603013

Related Diseases for Schizophrenia 6

Symptoms & Phenotypes for Schizophrenia 6

Clinical features from OMIM:

603013

Drugs & Therapeutics for Schizophrenia 6

Drugs for Schizophrenia 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rimonabant Approved, Investigational Phase 2 168273-06-1, 158681-13-1 104850
2 Anti-Obesity Agents Phase 2
3 Hormone Antagonists Phase 2
4 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
5 Cannabinoid Receptor Antagonists Phase 2
6 Neurotransmitter Agents Phase 2
7 Hormones Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effects of Rimonabant, on Weight and Metabolic Risk Factors Terminated NCT00547118 Phase 2 Rimonabant;Placebo
2 Cognitive Remediation Program for Hospitalized in the Long Term Patients With Deficit Schizophrenia Not yet recruiting NCT03407950 Not Applicable

Search NIH Clinical Center for Schizophrenia 6

Genetic Tests for Schizophrenia 6

Genetic tests related to Schizophrenia 6:

# Genetic test Affiliating Genes
1 Schizophrenia 6 30 NRG1

Anatomical Context for Schizophrenia 6

Publications for Schizophrenia 6

Articles related to Schizophrenia 6:

# Title Authors Year
1
A randomized controlled trial of a mindfulness-based intervention program for people with schizophrenia: 6-month follow-up. ( 27994466 )
2016

Variations for Schizophrenia 6

Expression for Schizophrenia 6

Search GEO for disease gene expression data for Schizophrenia 6.

Pathways for Schizophrenia 6

GO Terms for Schizophrenia 6

Biological processes related to Schizophrenia 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.16 EP300 NRG1
2 positive regulation of gene expression GO:0010628 8.96 EP300 NRG1
3 heart development GO:0007507 8.62 EP300 NRG1

Molecular functions related to Schizophrenia 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription coregulator activity GO:0003712 8.62 EP300 NRG1

Sources for Schizophrenia 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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