Schizophrenia 6 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Schizophrenia 6

MalaCards integrated aliases for Schizophrenia 6:

Name: Schizophrenia 6 ⁵⁸ ¹² ³⁰ ¹⁵ ⁷⁴

Schizophrenia Susceptibility Locus, Chromosome 8p-Related ⁵⁸ ¹³

Sczd6 ⁵⁸ ¹²

Schizophrenia, Type 6 ⁴¹

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Mental diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0070082

OMIM ⁵⁸ 603013

MedGen ⁴³ C1864275

UMLS ⁷⁴ C1864275

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Summaries for Schizophrenia 6

Disease Ontology : ¹² A schizophrenia that has material basis in an autosomal dominant mutation of SCZD6 on chromosome 8p21.

MalaCards based summary : Schizophrenia 6, also known as schizophrenia susceptibility locus, chromosome 8p-related, is related to schizophrenia and cone-rod dystrophy and hearing loss 2. An important gene associated with Schizophrenia 6 is NRG1 (Neuregulin 1), and among its related pathways/superpathways are Glioma and NF-KappaB Family Pathway. The drugs Rimonabant and Anti-Obesity Agents have been mentioned in the context of this disorder.

Description from OMIM: 603013

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Related Diseases for Schizophrenia 6

Diseases in the Schizophrenia family:

Schizophrenia 1	Schizophrenia 3
Schizophrenia 4	Schizophrenia 6
Schizophrenia 5	Schizophrenia 7
Schizophrenia 8	Schizophrenia 2
Schizophrenia 9	Schizophrenia 10
Schizophrenia 11	Schizophrenia 12
Schizophrenia 14	Schizophrenia 13
Schizophrenia 15	Schizophrenia 16
Schizophrenia 18	Schizophrenia 19
Early-Onset Schizophrenia

Diseases related to Schizophrenia 6 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	schizophrenia	11.4
2	cone-rod dystrophy and hearing loss 2	11.1
3	disease of mental health	9.6	EP300 NRG1

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Symptoms & Phenotypes for Schizophrenia 6

Clinical features from OMIM:

603013

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Drugs & Therapeutics for Schizophrenia 6

Drugs for Schizophrenia 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Rimonabant

Approved, Investigational

Phase 2

168273-06-1, 158681-13-1

104850

Synonyms:

[3H]SR141716A

168273-06-1

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide

5-(p-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidinopyrazole-3-carboxamide

A 281

AC-163720

AC1L2XM5

AC-731

Acomplia

Acomplia (TN)

C14319

CHEMBL111

CID104850

D05731

DB06155

I06-0381

L000572

LS-128155

MolPort-003-850-185

N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride

NCGC00164572-01

nchembio.129-comp21

nchembio.552-comp16

Rimonabant

Rimonabant (JAN/USAN/INN)

Rimonabant [USAN:INN]

Rimoslim

Riobant

Slimona

SR 141716

SR 141716a

SR141,716A

SR141716

SR-141716

SR141716a

SR141716A

SR-141716A

STK642500

UNII-RML78EN3XE

Zimulti

ZINC01540228

2

Anti-Obesity Agents

Phase 2

3

Hormone Antagonists

Phase 2

4

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 2

5

Cannabinoid Receptor Antagonists

Phase 2

6

Neurotransmitter Agents

Phase 2

7

Hormones

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	The Effects of Rimonabant, on Weight and Metabolic Risk Factors	Terminated	NCT00547118	Phase 2	Rimonabant;Placebo
2	Cognitive Remediation Program for Hospitalized in the Long Term Patients With Deficit Schizophrenia	Not yet recruiting	NCT03407950	Not Applicable

Search NIH Clinical Center for Schizophrenia 6

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Genetic Tests for Schizophrenia 6

Genetic tests related to Schizophrenia 6:

#	Genetic test	Affiliating Genes
1	Schizophrenia 6 ³⁰	NRG1

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Anatomical Context for Schizophrenia 6

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Publications for Schizophrenia 6

Articles related to Schizophrenia 6:

#	Title	Authors	Year
1	A randomized controlled trial of a mindfulness-based intervention program for people with schizophrenia: 6-month follow-up. ( 27994466 )	Wang LQ...Karatzias T	2016

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Genes for Schizophrenia 6

Genes related to Schizophrenia 6 (2 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NRG1	Neuregulin 1	Protein Coding	100	Genetic Tests ³⁰
2	SCZD6	Schizophrenia Disorder 6	Genetic Locus	50	Genetic linkage ⁵⁸ Susceptibility factor ⁵⁸
3	EP300	E1A Binding Protein P300	Protein Coding	15.37	DISEASES inferred ¹⁵

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Variations for Schizophrenia 6

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Expression for Schizophrenia 6

Search GEO for disease gene expression data for Schizophrenia 6.

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Pathways for Schizophrenia 6

Pathways related to Schizophrenia 6 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Glioma ³⁸ Show member pathways Endocrine resistance ³⁸ Melanoma ³⁸ Non-small cell lung cancer ³⁸ Signaling Pathways in Glioblastoma ¹	11.96	EP300 NRG1
2	NF-KappaB Family Pathway ⁶⁵ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁵	11.94	EP300 NRG1
3	ErbB signaling pathway ¹ ³⁸ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶² EGFR tyrosine kinase inhibitor resistance ³⁸ Renal cell carcinoma ³⁸ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	11.71	EP300 NRG1
4	Development Ligand-independent activation of ESR1 and ESR2 ²³ Show member pathways Transcription CREB pathway ²³ Transcription PPAR Pathway ²³	11.28	EP300 NRG1
5	Immune response IFN gamma signaling pathway ²³ Show member pathways IFN-gamma pathway ¹	11.27	EP300 NRG1
6	Transcription Androgen Receptor nuclear signaling ²³ Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²³	10.79	EP300 NRG1

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GO Terms for Schizophrenia 6

Biological processes related to Schizophrenia 6 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nervous system development	GO:0007399	9.16	EP300 NRG1
2	positive regulation of gene expression	GO:0010628	8.96	EP300 NRG1
3	heart development	GO:0007507	8.62	EP300 NRG1

Molecular functions related to Schizophrenia 6 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transcription coregulator activity	GO:0003712	8.62	EP300 NRG1

Sources

Sources for Schizophrenia 6

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Schizophrenia 6 (SCZD6)

Aliases & Classifications for Schizophrenia 6

MalaCards integrated aliases for Schizophrenia 6:

Classifications:

External Ids:

Summaries for Schizophrenia 6

Related Diseases for Schizophrenia 6

Diseases in the Schizophrenia family:

Diseases related to Schizophrenia 6 via text searches within MalaCards or GeneCards Suite gene sharing:

Symptoms & Phenotypes for Schizophrenia 6

Clinical features from OMIM:

Drugs & Therapeutics for Schizophrenia 6

Drugs for Schizophrenia 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Schizophrenia 6

Genetic tests related to Schizophrenia 6:

Anatomical Context for Schizophrenia 6

Publications for Schizophrenia 6

Articles related to Schizophrenia 6:

Genes for Schizophrenia 6

Genes related to Schizophrenia 6 (2 elite genes):

Variations for Schizophrenia 6

Expression for Schizophrenia 6

Pathways for Schizophrenia 6

Pathways related to Schizophrenia 6 according to GeneCards Suite gene sharing:

GO Terms for Schizophrenia 6

Biological processes related to Schizophrenia 6 according to GeneCards Suite gene sharing:

Molecular functions related to Schizophrenia 6 according to GeneCards Suite gene sharing:

Sources for Schizophrenia 6