Schizophrenia 6 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Schizophrenia 6

MalaCards integrated aliases for Schizophrenia 6:

Name: Schizophrenia 6 ⁵⁷ ¹² ²⁹ ¹⁵ ⁷³

Sczd6 ⁵⁷ ¹²

Schizophrenia Susceptibility Locus, Chromosome 8p-Related ⁵⁷

Schizophrenia, Type 6 ⁴⁰

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Mental diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁷ 603013

Disease Ontology ¹² DOID:0070082

MedGen ⁴² C1864275

UMLS ⁷³ C1864275

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Summaries for Schizophrenia 6

Disease Ontology : ¹² A schizophrenia that has material basis in an autosomal dominant mutation of SCZD6 on chromosome 8p21.

MalaCards based summary : Schizophrenia 6, also known as sczd6, is related to schizophrenia and perrault syndrome 1. An important gene associated with Schizophrenia 6 is NRG1 (Neuregulin 1), and among its related pathways/superpathways are Glioma and NF-KappaB Family Pathway. The drugs Rimonabant and Hormones have been mentioned in the context of this disorder.

Description from OMIM: 603013

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Related Diseases for Schizophrenia 6

Diseases in the Schizophrenia family:

Schizophrenia 1	Schizophrenia 3
Schizophrenia 4	Schizophrenia 6
Schizophrenia 5	Schizophrenia 7
Schizophrenia 8	Schizophrenia 2
Schizophrenia 9	Schizophrenia 10
Schizophrenia 11	Schizophrenia 12
Schizophrenia 14	Schizophrenia 13
Schizophrenia 15	Schizophrenia 16
Schizophrenia 18	Schizophrenia 19
Early-Onset Schizophrenia

Diseases related to Schizophrenia 6 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	schizophrenia	11.3
2	perrault syndrome 1	11.1
3	disease of mental health	9.8	EP300 NRG1

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Symptoms & Phenotypes for Schizophrenia 6

Clinical features from OMIM:

603013

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Drugs & Therapeutics for Schizophrenia 6

Drugs for Schizophrenia 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Rimonabant

Approved, Investigational

Phase 2

158681-13-1, 168273-06-1

104850

Synonyms:

[3H]SR141716A

168273-06-1

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide

5-(p-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidinopyrazole-3-carboxamide

A 281

AC-163720

AC1L2XM5

AC-731

Acomplia

Acomplia (TN)

C14319

CHEMBL111

CID104850

D05731

DB06155

I06-0381

L000572

LS-128155

MolPort-003-850-185

N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride

NCGC00164572-01

nchembio.129-comp21

nchembio.552-comp16

Rimonabant

Rimonabant (JAN/USAN/INN)

Rimonabant [USAN:INN]

Rimoslim

Riobant

Slimona

SR 141716

SR 141716a

SR141,716A

SR141716

SR-141716

SR141716a

SR141716A

SR-141716A

STK642500

UNII-RML78EN3XE

Zimulti

ZINC01540228

2

Hormones

Phase 2

3

Cannabinoid Receptor Antagonists

Phase 2

4

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 2

5

Hormone Antagonists

Phase 2

6

Neurotransmitter Agents

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	The Effects of Rimonabant, on Weight and Metabolic Risk Factors	Terminated	NCT00547118	Phase 2	Rimonabant;Placebo
2	Cognitive Remediation Program for Hospitalized in the Long Term Patients With Deficit Schizophrenia	Not yet recruiting	NCT03407950	Not Applicable

Search NIH Clinical Center for Schizophrenia 6

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Genetic Tests for Schizophrenia 6

Genetic tests related to Schizophrenia 6:

#	Genetic test	Affiliating Genes
1	Schizophrenia 6 ²⁹	NRG1

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Anatomical Context for Schizophrenia 6

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Publications for Schizophrenia 6

Articles related to Schizophrenia 6:

#	Title	Authors	Year
1	A randomized controlled trial of a mindfulness-based intervention program for people with schizophrenia: 6-month follow-up. ( 27994466 )	Wang L.Q....Karatzias T.	2016

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Genes for Schizophrenia 6

Genes related to Schizophrenia 6 (2 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NRG1	Neuregulin 1	Protein Coding	100	Genetic Tests ²⁹
2	SCZD6	Schizophrenia Disorder 6	Genetic Locus	50	Genetic linkage ⁵⁷ Susceptibility factor ⁵⁷
3	EP300	E1A Binding Protein P300	Protein Coding	15.34	DISEASES inferred ¹⁵

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Variations for Schizophrenia 6

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Expression for Schizophrenia 6

Search GEO for disease gene expression data for Schizophrenia 6.

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Pathways for Schizophrenia 6

Pathways related to Schizophrenia 6 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.04	EP300 NRG1
2	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	11.94	EP300 NRG1
3	ErbB signaling pathway ¹ ³⁷ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶¹ Renal cell carcinoma ³⁷ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	11.6	EP300 NRG1
4	Development Ligand-independent activation of ESR1 and ESR2 ²² Show member pathways Transcription CREB pathway ²² Transcription PPAR Pathway ²²	11.28	EP300 NRG1
5	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.27	EP300 NRG1
6	Transcription Androgen Receptor nuclear signaling ²² Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²²	10.79	EP300 NRG1

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GO Terms for Schizophrenia 6

Biological processes related to Schizophrenia 6 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nervous system development	GO:0007399	9.16	EP300 NRG1
2	positive regulation of gene expression	GO:0010628	8.96	EP300 NRG1
3	heart development	GO:0007507	8.62	EP300 NRG1

Molecular functions related to Schizophrenia 6 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transcription coregulator activity	GO:0003712	8.62	EP300 NRG1

Sources

Sources for Schizophrenia 6

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Schizophrenia 6 (SCZD6)

Aliases & Classifications for Schizophrenia 6

MalaCards integrated aliases for Schizophrenia 6:

Classifications:

External Ids:

Summaries for Schizophrenia 6

Related Diseases for Schizophrenia 6

Diseases in the Schizophrenia family:

Diseases related to Schizophrenia 6 via text searches within MalaCards or GeneCards Suite gene sharing:

Symptoms & Phenotypes for Schizophrenia 6

Clinical features from OMIM:

Drugs & Therapeutics for Schizophrenia 6

Drugs for Schizophrenia 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Schizophrenia 6

Genetic tests related to Schizophrenia 6:

Anatomical Context for Schizophrenia 6

Publications for Schizophrenia 6

Articles related to Schizophrenia 6:

Genes for Schizophrenia 6

Genes related to Schizophrenia 6 (2 elite genes):

Variations for Schizophrenia 6

Expression for Schizophrenia 6

Pathways for Schizophrenia 6

Pathways related to Schizophrenia 6 according to GeneCards Suite gene sharing:

GO Terms for Schizophrenia 6

Biological processes related to Schizophrenia 6 according to GeneCards Suite gene sharing:

Molecular functions related to Schizophrenia 6 according to GeneCards Suite gene sharing:

Sources for Schizophrenia 6