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SCZD6
MCID: SCH081
MIFTS: 32

Schizophrenia 6 (SCZD6)

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Schizophrenia 6

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MalaCards integrated aliases for Schizophrenia 6:

Name: Schizophrenia 6 56 12 29 15 71
Schizophrenia Susceptibility Locus, Chromosome 8p-Related 56 13
Sczd6 56 12
Schizophrenia, Type 6 39

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Mental diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0070082
OMIM 56 603013
MedGen 41 C1864275
UMLS 71 C1864275
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Summaries for Schizophrenia 6

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Disease Ontology : 12 A schizophrenia that has material basis in an autosomal dominant mutation of SCZD6 on chromosome 8p21.

MalaCards based summary : Schizophrenia 6, also known as schizophrenia susceptibility locus, chromosome 8p-related, is related to schizophrenia and myocardial infarction. An important gene associated with Schizophrenia 6 is NRG1 (Neuregulin 1), and among its related pathways/superpathways are Circadian entrainment and Calcium signaling pathway. The drugs Tranquilizing Agents and Antipsychotic Agents have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and testes.

More information from OMIM: 603013
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Related Diseases for Schizophrenia 6

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Diseases in the Schizophrenia family:

Schizophrenia 1 Schizophrenia 3
Schizophrenia 4 Schizophrenia 6
Schizophrenia 5 Schizophrenia 7
Schizophrenia 8 Schizophrenia 2
Schizophrenia 9 Schizophrenia 10
Schizophrenia 11 Schizophrenia 12
Schizophrenia 14 Schizophrenia 13
Schizophrenia 15 Schizophrenia 16
Schizophrenia 18 Schizophrenia 19
Early-Onset Schizophrenia

Diseases related to Schizophrenia 6 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 schizophrenia 26.9 SCZD6 PPP3CC PIP4K2A NRG1 GRM5 DAOA
2 myocardial infarction 9.7
3 acute myocardial infarction 9.7
4 schizotypal personality disorder 9.6 NRG1 DAOA
5 psychotic disorder 9.5 NRG1 GRM5 DAOA
6 schizophrenia 11 9.2 TRDN PPP3CC MIR662 MIR657
7 bipolar disorder 8.8 PIP4K2A NRG1 GRM5 DAOA

Graphical network of the top 20 diseases related to Schizophrenia 6:



Diseases related to Schizophrenia 6
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Symptoms & Phenotypes for Schizophrenia 6

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Clinical features from OMIM:

603013
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Drugs & Therapeutics for Schizophrenia 6

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Drugs for Schizophrenia 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Tranquilizing Agents Phase 3
2 Antipsychotic Agents Phase 3
3 Psychotropic Drugs Phase 3
4 Central Nervous System Depressants Phase 3
5 Antidepressive Agents Phase 3
6 Quetiapine Fumarate Phase 3 111974-72-2
7
Oxytocin Approved, Vet_approved Phase 2 50-56-6 439302 53477758
8
Olanzapine Approved, Investigational Phase 2 132539-06-1 4585
9
Rimonabant Approved, Investigational Phase 2 168273-06-1, 158681-13-1 104850
10 Oxytocics Phase 2
11 Antiemetics Phase 2
12 Serotonin Uptake Inhibitors Phase 2
13 Gastrointestinal Agents Phase 2
14 Autonomic Agents Phase 2
15 Serotonin Agents Phase 2
16 Neurotransmitter Agents Phase 2
17 Anti-Obesity Agents Phase 2
18 Hormone Antagonists Phase 2
19 Hormones Phase 2
20
Serine Investigational, Nutraceutical Phase 2 56-45-1 5951
21
Serotonin Investigational, Nutraceutical Phase 2 50-67-9 5202
22
Dopamine Approved 51-61-6, 62-31-7 681
23 Dopamine Agents
24 Dopamine D2 Receptor Antagonists
25 Serotonin 5-HT2 Receptor Antagonists
26 Dopamine Antagonists
27 Serotonin Antagonists
28 Paliperidone Palmitate

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 6-week Multicenter, Double-blind, Randomized, Parallel-group, Phase 3 Study to Evaluate the Feasibility of Switching From Immediate-release Quetiapine Fumarate (SEROQUEL) to Sustained-release Quetiapine Fumarate in Outpatients With Schizophrenia (Abbreviated) Completed NCT00206128 Phase 3 Seroquel SR
2 A Randomized Trial Administering Oxytocin vs Placebo as add-on to Antipsychotics in Patients With Schizophrenia and Schizo-affective Disorder Unknown status NCT01598623 Phase 2 Oxytocin
3 D-serine Antipsychotic Monotherapy for Treatment Refractory Schizophrenia Completed NCT00816894 Phase 2 D-serine;Olanzapine
4 The Effects of the Cannabinoid-1 Receptor Antagonist, Rimonabant, on Weight and Metabolic Risk Factors in People With Schizophrenia Terminated NCT00547118 Phase 2 Rimonabant;Placebo
5 Expanding Rapid Ascertainment Networks of Schizophrenia Families in Taiwan Unknown status NCT01357005
6 Expanding Rapid Ascertainment Network of Schizophrenia Families in Taiwan Unknown status NCT01249079
7 Expanding Rapid Ascertainment Networks of Schizophrenia Families in Taiwan Unknown status NCT01077687
8 INVega Is Studied In an Observational Design in the Netherlands Completed NCT00697658 Paliperidone ER
9 The Effectiveness of The Meta-cognitive Training Among Chronic Schizophrenia Patients Treated Within Community Support Groups in Poland. Completed NCT02187692
10 Cognitive Remediation Program for Hospitalized in the Long Term Patients With Deficit Schizophrenia : Impact on the Capacities of Autonomy Not yet recruiting NCT03407950
11 A Study on Etiological Factors of Schizophrenia Terminated NCT00155636

Search NIH Clinical Center for Schizophrenia 6

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Genetic Tests for Schizophrenia 6

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Genetic tests related to Schizophrenia 6:

# Genetic test Affiliating Genes
1 Schizophrenia 6 29 NRG1
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Anatomical Context for Schizophrenia 6

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MalaCards organs/tissues related to Schizophrenia 6:

40
Cortex, Brain, Testes, Prefrontal Cortex
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Publications for Schizophrenia 6

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Articles related to Schizophrenia 6:

(show top 50) (show all 53)
# Title Authors PMID Year
1
Extreme population differences across Neuregulin 1 gene, with implications for association studies. 56
16189508 2006
2
No evidence for linkage or association of neuregulin-1 (NRG1) with disease in the Irish study of high-density schizophrenia families (ISHDSF). 56
15197397 2004
3
Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. 56
15007393 2004
4
No association with the neuregulin 1 haplotype to Japanese schizophrenia. 56
14699424 2004
5
Polymorphisms within 5' end of the Neuregulin 1 gene are genetically associated with schizophrenia in the Chinese population. 56
14647391 2004
6
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. 56
12851457 2003
7
Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. 56
12851458 2003
8
Neuregulin 1 and susceptibility to schizophrenia. 56
12145742 2002
9
Genetic association studies of schizophrenia using the 8p21-22 genes: prepronociceptin (PNOC), neuronal nicotinic cholinergic receptor alpha polypeptide 2 (CHRNA2) and arylamine N-acetyltransferase 1 (NAT1). 56
11436130 2001
10
Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. 56
9731535 1998
11
NIMH Genetics Initiative Millenium Schizophrenia Consortium: linkage analysis of African-American pedigrees. 56
9674972 1998
12
Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families. 56
8942448 1996
13
The Johns Hopkins University Collaborative Schizophrenia Study: an epidemiologic-genetic approach to test the heterogeneity hypothesis and identify schizophrenia susceptibility genes. 56
9246505 1996
14
The vicious circle of social exclusion and psychopathology: a systematic review of experimental ostracism research in psychiatric disorders. 61
31586242 2019
15
Clinical staging in severe mental disorders; bipolar disorder, depression and schizophrenia. 61
30314812 2019
16
Schizophrenia is a later-onset feature of PCDH19 Girls Clustering Epilepsy. 61
30828795 2019
17
A randomized controlled trial of a mindfulness-based intervention program for people with schizophrenia: 6-month follow-up. 61
27994466 2016
18
Monitoring of physical health parameters for inpatients on a child and adolescent mental health unit receiving regular antipsychotic therapy. 61
26734455 2015
19
Trajectories of antipsychotic response in drug-naive schizophrenia patients: results from the 6-month ESPASS follow-up study. 61
23600715 2014
20
A modified Drug Attitude Inventory used in long-term patients in sheltered housing. 61
23265955 2013
21
Burden of disease in adolescents and young people in Spain. 61
23084798 2013
22
Early-onset schizophrenia. 61
22797279 2012
23
Efficacy and safety of second-generation antipsychotics in children and adolescents with psychotic and bipolar spectrum disorders: comprehensive review of prospective head-to-head and placebo-controlled comparisons. 61
20702068 2011
24
MMPI-II personality profiles of patients with psychogenic nonepileptic seizures. 61
21450531 2011
25
Follow-up of subjects with suspected pre-psychotic state in Taiwan. 61
21112187 2011
26
[Clinical-genetic parameters and the nosological evaluation of schizoaffective psychosis in systematics of attack-like endogenous psychoses]. 61
21512496 2011
27
Diffusion tensor anisotropy in the cingulate gyrus in schizophrenia. 61
20045072 2010
28
Increased risk of acute myocardial infarction after acute episode of schizophrenia: 6 year follow-up study. 61
20050720 2010
29
Increased cortical inhibition in persons with schizophrenia treated with clozapine. 61
18308816 2008
30
GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [11C]Ro15-4513, a radioligand with relatively high affinity for alpha5 subunit. 61
18042347 2008
31
Urticaria and angio-oedema due to ziprasidone. 61
17446198 2007
32
Neurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance. 61
17943687 2007
33
Dysfunction of dorsolateral prefrontal cortex in antipsychotic-naïve schizophreniform psychosis. 61
17052898 2006
34
Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. 61
16275808 2005
35
Hypermetabolic pattern in frontal cortex and other brain regions in unmedicated schizophrenia patients. Results from a FDG-PET study. 61
15834758 2005
36
Longitudinal course of schizophrenia spectrum symptoms in offspring of psychiatrically hospitalized mothers. 61
16092904 2005
37
Effectiveness of antipsychotic treatment for schizophrenia: 6-month results of the Pan-European Schizophrenia Outpatient Health Outcomes (SOHO) study. 61
15701107 2005
38
[Distribution of latencies of visual evoked potentials in a sample of schizophrenic patients]. 61
14727371 2003
39
A cluster-analytic investigation of MMPI profiles of serious male and female juvenile offenders. 61
12819436 2003
40
Mental illness and menopause: a patient and family perspective. 61
12814000 2003
41
Association between the serotonin 2A receptor gene and tardive dyskinesia in chronic schizophrenia. 61
11317227 2001
42
[Morphometric study of ultrastructural changes in oligodendroglial cells in the postmortem brain in endogenous psychoses]. 61
11523429 2001
43
The carbohydrate deposits detected by histochemical methods in the molecular layer of the dentate gyrus in the hippocampal formation of patients with schizophrenia, Down's syndrome and dementia, and aged person. 61
11443283 2000
44
Adverse behavioral events reported in patients taking alprazolam and other benzodiazepines. 61
8262890 1993
45
Auditory P300 studies in schizophrenic subjects and their first degree relatives. 61
1642573 1992
46
[Review of the concept of personality deterioration in schizophrenia]. 61
1862715 1991
47
[Suicidal tendencies in endogenous and organic depression in elderly patients]. 61
3232462 1988
48
Sialic acid in platelets of schizophrenic patients. 61
3363163 1988
49
Drug-induced growth hormone and prolactin responses in schizophrenia research. 61
6131495 1982
50
Efficacy of loxapine in the treatment of paranoid schizophrenia. 61
14350 1977
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Variations for Schizophrenia 6

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Expression for Schizophrenia 6

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Search GEO for disease gene expression data for Schizophrenia 6.
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Pathways for Schizophrenia 6

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Pathways related to Schizophrenia 6 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Circadian entrainment 36
Show member pathways
 11.8 PPP3CC HOMER3 GRM5
2
Calcium signaling pathway 36
Show member pathways
 11.09 TRDN PPP3CC GRM5
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GO Terms for Schizophrenia 6

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Biological processes related to Schizophrenia 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 locomotory behavior GO:0007626 9.16 NRG1 GRM5
2 positive regulation of protein tyrosine kinase activity GO:0061098 8.96 NRG1 GRM5
3 G protein-coupled glutamate receptor signaling pathway GO:0007216 8.62 HOMER3 GRM5

Molecular functions related to Schizophrenia 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activator activity GO:0030296 8.62 NRG1 GRM5
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Sources for Schizophrenia 6

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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