SCZD6
MCID: SCH081
MIFTS: 27

Schizophrenia 6 (SCZD6)

Categories: Ear diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Schizophrenia 6

MalaCards integrated aliases for Schizophrenia 6:

Name: Schizophrenia 6 57 12 29 15 70
Schizophrenia Susceptibility Locus, Chromosome 8p-Related 57 13
Sczd6 57 12
Schizophrenia, Type 6 39

Classifications:



External Ids:

Disease Ontology 12 DOID:0070082
OMIM® 57 603013
MedGen 41 C1864275
UMLS 70 C1864275

Summaries for Schizophrenia 6

Disease Ontology : 12 A schizophrenia that has material basis in an autosomal dominant mutation of SCZD6 on chromosome 8p21.

MalaCards based summary : Schizophrenia 6, also known as schizophrenia susceptibility locus, chromosome 8p-related, is related to schizophrenia and schizoaffective disorder. An important gene associated with Schizophrenia 6 is NRG1 (Neuregulin 1), and among its related pathways/superpathways are Calcium signaling pathway and Long-term potentiation. Affiliated tissues include cortex, prefrontal cortex and brain.

More information from OMIM: 603013

Related Diseases for Schizophrenia 6

Graphical network of the top 20 diseases related to Schizophrenia 6:



Diseases related to Schizophrenia 6

Symptoms & Phenotypes for Schizophrenia 6

Clinical features from OMIM®:

603013 (Updated 20-May-2021)

Drugs & Therapeutics for Schizophrenia 6

Search Clinical Trials , NIH Clinical Center for Schizophrenia 6

Genetic Tests for Schizophrenia 6

Genetic tests related to Schizophrenia 6:

# Genetic test Affiliating Genes
1 Schizophrenia 6 29 NRG1

Anatomical Context for Schizophrenia 6

MalaCards organs/tissues related to Schizophrenia 6:

40
Cortex, Prefrontal Cortex, Brain

Publications for Schizophrenia 6

Articles related to Schizophrenia 6:

(show top 50) (show all 56)
# Title Authors PMID Year
1
Extreme population differences across Neuregulin 1 gene, with implications for association studies. 57
16189508 2006
2
No evidence for linkage or association of neuregulin-1 (NRG1) with disease in the Irish study of high-density schizophrenia families (ISHDSF). 57
15197397 2004
3
Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. 57
15007393 2004
4
No association with the neuregulin 1 haplotype to Japanese schizophrenia. 57
14699424 2004
5
Polymorphisms within 5' end of the Neuregulin 1 gene are genetically associated with schizophrenia in the Chinese population. 57
14647391 2004
6
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. 57
12851457 2003
7
Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. 57
12851458 2003
8
Neuregulin 1 and susceptibility to schizophrenia. 57
12145742 2002
9
Genetic association studies of schizophrenia using the 8p21-22 genes: prepronociceptin (PNOC), neuronal nicotinic cholinergic receptor alpha polypeptide 2 (CHRNA2) and arylamine N-acetyltransferase 1 (NAT1). 57
11436130 2001
10
Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. 57
9731535 1998
11
NIMH Genetics Initiative Millenium Schizophrenia Consortium: linkage analysis of African-American pedigrees. 57
9674972 1998
12
Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families. 57
8942448 1996
13
The Johns Hopkins University Collaborative Schizophrenia Study: an epidemiologic-genetic approach to test the heterogeneity hypothesis and identify schizophrenia susceptibility genes. 57
9246505 1996
14
COVID-19 impacts the expression of molecular markers associated with neuropsychiatric disorders. 61
33521688 2021
15
Longitudinal trajectory analysis of antipsychotic response in patients with schizophrenia: 6-week, randomised, open-label, multicentre clinical trial. 61
33090091 2020
16
The vicious circle of social exclusion and psychopathology: a systematic review of experimental ostracism research in psychiatric disorders. 61
31586242 2020
17
The 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome: In Silico Analyses of the Four Coding Genes Reveal Functional Associations with Neurodevelopmental Phenotypes. 61
32384786 2020
18
Clinical staging in severe mental disorders; bipolar disorder, depression and schizophrenia. 61
30314812 2019
19
Schizophrenia is a later-onset feature of PCDH19 Girls Clustering Epilepsy. 61
30828795 2019
20
A randomized controlled trial of a mindfulness-based intervention program for people with schizophrenia: 6-month follow-up. 61
27994466 2016
21
Monitoring of physical health parameters for inpatients on a child and adolescent mental health unit receiving regular antipsychotic therapy. 61
26734455 2015
22
Trajectories of antipsychotic response in drug-naive schizophrenia patients: results from the 6-month ESPASS follow-up study. 61
23600715 2014
23
A modified Drug Attitude Inventory used in long-term patients in sheltered housing. 61
23265955 2013
24
Burden of disease in adolescents and young people in Spain. 61
23084798 2013
25
Early-onset schizophrenia. 61
22797279 2012
26
Efficacy and safety of second-generation antipsychotics in children and adolescents with psychotic and bipolar spectrum disorders: comprehensive review of prospective head-to-head and placebo-controlled comparisons. 61
20702068 2011
27
MMPI-II personality profiles of patients with psychogenic nonepileptic seizures. 61
21450531 2011
28
Follow-up of subjects with suspected pre-psychotic state in Taiwan. 61
21112187 2011
29
[Clinical-genetic parameters and the nosological evaluation of schizoaffective psychosis in systematics of attack-like endogenous psychoses]. 61
21512496 2011
30
Diffusion tensor anisotropy in the cingulate gyrus in schizophrenia. 61
20045072 2010
31
Increased risk of acute myocardial infarction after acute episode of schizophrenia: 6 year follow-up study. 61
20050720 2010
32
Increased cortical inhibition in persons with schizophrenia treated with clozapine. 61
18308816 2008
33
GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [11C]Ro15-4513, a radioligand with relatively high affinity for alpha5 subunit. 61
18042347 2008
34
Urticaria and angio-oedema due to ziprasidone. 61
17446198 2007
35
Neurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance. 61
17943687 2007
36
Dysfunction of dorsolateral prefrontal cortex in antipsychotic-naïve schizophreniform psychosis. 61
17052898 2006
37
Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. 61
16275808 2005
38
Hypermetabolic pattern in frontal cortex and other brain regions in unmedicated schizophrenia patients. Results from a FDG-PET study. 61
15834758 2005
39
Longitudinal course of schizophrenia spectrum symptoms in offspring of psychiatrically hospitalized mothers. 61
16092904 2005
40
Effectiveness of antipsychotic treatment for schizophrenia: 6-month results of the Pan-European Schizophrenia Outpatient Health Outcomes (SOHO) study. 61
15701107 2005
41
[Distribution of latencies of visual evoked potentials in a sample of schizophrenic patients]. 61
14727371 2003
42
A cluster-analytic investigation of MMPI profiles of serious male and female juvenile offenders. 61
12819436 2003
43
Mental illness and menopause: a patient and family perspective. 61
12814000 2003
44
Association between the serotonin 2A receptor gene and tardive dyskinesia in chronic schizophrenia. 61
11317227 2001
45
[Morphometric study of ultrastructural changes in oligodendroglial cells in the postmortem brain in endogenous psychoses]. 61
11523429 2001
46
The carbohydrate deposits detected by histochemical methods in the molecular layer of the dentate gyrus in the hippocampal formation of patients with schizophrenia, Down's syndrome and dementia, and aged person. 61
11443283 2000
47
Adverse behavioral events reported in patients taking alprazolam and other benzodiazepines. 61
8262890 1993
48
Auditory P300 studies in schizophrenic subjects and their first degree relatives. 61
1642573 1992
49
[Review of the concept of personality deterioration in schizophrenia]. 61
1862715 1991
50
[Suicidal tendencies in endogenous and organic depression in elderly patients]. 61
3232462 1988

Variations for Schizophrenia 6

Expression for Schizophrenia 6

Search GEO for disease gene expression data for Schizophrenia 6.

Pathways for Schizophrenia 6

Pathways related to Schizophrenia 6 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.18 TRDN PPP3CC GRM5
2
Show member pathways
10.99 PPP3CC GRM5

GO Terms for Schizophrenia 6

Biological processes related to Schizophrenia 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 locomotory behavior GO:0007626 9.26 NRG1 GRM5
2 cytoplasmic microtubule organization GO:0031122 9.16 TRDN PCM1
3 positive regulation of protein tyrosine kinase activity GO:0061098 8.96 NRG1 GRM5
4 G protein-coupled glutamate receptor signaling pathway GO:0007216 8.62 HOMER3 GRM5

Molecular functions related to Schizophrenia 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activator activity GO:0030296 8.62 NRG1 GRM5

Sources for Schizophrenia 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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