SCZD7
MCID: SCH083
MIFTS: 29

Schizophrenia 7 (SCZD7)

Categories: Ear diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Schizophrenia 7

MalaCards integrated aliases for Schizophrenia 7:

Name: Schizophrenia 7 57 12 15
Schizophrenia Susceptibility Locus, Chromosome 13q-Related 57 13
Sczd7 57 12
Schizophrenia 7 with or Without an Affective Disorder 57

Classifications:



External Ids:

Disease Ontology 12 DOID:0070083
OMIM® 57 603176
MedGen 41 C1864152

Summaries for Schizophrenia 7

Disease Ontology : 12 A schizophrenia that has material basis in an autosomal dominant mutation of SCZD7 on chromosome 13q32.

MalaCards based summary : Schizophrenia 7, also known as schizophrenia susceptibility locus, chromosome 13q-related, is related to schizophrenia and non-syndromic intellectual disability. An important gene associated with Schizophrenia 7 is SCZD7 (Schizophrenia Disorder 7), and among its related pathways/superpathways are Amphetamine addiction and Long-term potentiation. Affiliated tissues include eye, temporal lobe and brain.

More information from OMIM: 603176

Related Diseases for Schizophrenia 7

Diseases in the Schizophrenia family:

Schizophrenia 1 Schizophrenia 3
Schizophrenia 4 Schizophrenia 6
Schizophrenia 5 Schizophrenia 7
Schizophrenia 8 Schizophrenia 2
Schizophrenia 9 Schizophrenia 10
Schizophrenia 11 Schizophrenia 12
Schizophrenia 14 Schizophrenia 13
Schizophrenia 15 Schizophrenia 16
Schizophrenia 18 Schizophrenia 19
Early-Onset Schizophrenia

Diseases related to Schizophrenia 7 via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 19, show less)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 28.2 SMARCA2 SCZD7 GRIN2D GRIN1 DAOA
2 non-syndromic intellectual disability 10.0 SMARCA2 H2AC18
3 floating-harbor syndrome 10.0 SMARCA2 H2AC18
4 alpha thalassemia-x-linked intellectual disability syndrome 10.0 SMARCA2 H2AC18
5 epilepsy, familial temporal lobe, 1 10.0 SMARCA2 H2AC18
6 uv-sensitive syndrome 10.0 SMARCA2 H2AC18
7 chromosome 16p13.3 deletion syndrome, proximal 10.0 SMARCA2 H2AC18
8 rhabdoid cancer 9.9 SMARCA2 H2AC18
9 cartilage-hair hypoplasia 9.9 SMARCA2 H2AC18
10 immunodeficiency-centromeric instability-facial anomalies syndrome 9.9 SMARCA2 H2AC18
11 charge syndrome 9.9 SMARCA2 H2AC18
12 alcohol use disorder 9.8 H2AC18 GABBR2
13 psychotic disorder 9.8 SMARCA2 H2AC18 DAOA
14 high pressure neurological syndrome 9.8 GRIN2D GRIN1
15 autosomal dominant non-syndromic intellectual disability 6 9.7 GRIN2D GRIN1
16 tobacco addiction 9.7 H2AC18 GABBR2
17 autosomal dominant non-syndromic intellectual disability 9.6 SMARCA2 H2AC18 GRIN1
18 rett syndrome 9.5 H2AC18 GRIN1 GABBR2
19 disease of mental health 8.7 SMARCA2 H2AC18 GRIN2D GRIN1 GABBR2 DAOA

Graphical network of the top 20 diseases related to Schizophrenia 7:



Diseases related to Schizophrenia 7

Symptoms & Phenotypes for Schizophrenia 7

Clinical features from OMIM®:

603176 (Updated 20-May-2021)

Drugs & Therapeutics for Schizophrenia 7

Search Clinical Trials , NIH Clinical Center for Schizophrenia 7

Genetic Tests for Schizophrenia 7

Anatomical Context for Schizophrenia 7

MalaCards organs/tissues related to Schizophrenia 7:

40
Eye, Temporal Lobe, Brain

Publications for Schizophrenia 7

Articles related to Schizophrenia 7:

(showing 35, show less)
# Title Authors PMID Year
1
Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. 57
16585465 2006
2
Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis. 57
15271585 2004
3
Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. 57
12647258 2003
4
Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. 57
12364586 2002
5
Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. 57
10784452 2000
6
Linkage of familial schizophrenia to chromosome 13q32. 57
10486329 1999
7
Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. 57
9731535 1998
8
A genome-wide search for schizophrenia susceptibility genes. 57
9754621 1998
9
The Johns Hopkins University Collaborative Schizophrenia Study: an epidemiologic-genetic approach to test the heterogeneity hypothesis and identify schizophrenia susceptibility genes. 57
9246505 1996
10
Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32. 57
8746410 1995
11
Delusional Themes Across Affective and Non-Affective Psychoses. 61
29674982 2018
12
What are the top 10 physical activity research questions in schizophrenia? 61
26728764 2016
13
Electroencephalographic findings in schizophreniform and affective disorders. 61
27181256 2016
14
Anti-N-methyl-d-aspartate receptor encephalitis in a patient with a 7-year history of being diagnosed as schizophrenia: complexities in diagnosis and treatment. 61
26089673 2015
15
Volumetric abnormalities predating the onset of schizophrenia and affective psychoses: an MRI study in subjects at ultrahigh risk of psychosis. 61
21518921 2012
16
Structural correlates of auditory hallucinations in schizophrenia: a meta-analysis. 61
22341902 2012
17
Outcome in males with first-episode schizophrenia: 7-year follow-up. 61
21087079 2011
18
Should we expand the toolbox of psychiatric treatment methods to include Repetitive Transcranial Magnetic Stimulation (rTMS)? A meta-analysis of the efficacy of rTMS in psychiatric disorders. 61
20361902 2010
19
Perfusion magnetic resonance imaging in psychiatry. 61
19363433 2008
20
Serum substance P levels in patients with chronic schizophrenia treated with typical or atypical antipsychotics. 61
18728797 2008
21
Psychoeducation in schizophrenia: 7-year follow-up concerning rehospitalization and days in hospital in the Munich Psychosis Information Project Study. 61
17592908 2007
22
A survey of the off-label use of mood stabilizers in a large psychiatric hospital. 61
15982996 2005
23
Probing cortical dopamine function in schizophrenia: what can D1 receptors tell us? 61
16946930 2003
24
Neuronal nicotinic acetylcholine receptors: involvement in Alzheimer's disease and schizophrenia. 61
17715584 2002
25
Proton magnetic resonance spectroscopy of lenticular nuclei in simple schizophrenia. 61
10958147 2000
26
Services to families of adults with schizophrenia: from treatment recommendations to dissemination. 61
10030482 1999
27
Cerebral ventricle-brain ratio in monozygotic twins discordant and concordant for schizophrenia. 61
9789887 1998
28
Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease. 61
8950416 1996
29
3H-spiperone binding to peripheral mononuclear cells in psychiatric in-patients. 61
8771601 1996
30
Clinical characteristics of late-onset schizophrenia and delusional disorder. 61
8303221 1993
31
Dichotic listening in monozygotic twins discordant and concordant for schizophrenia. 61
1515379 1992
32
TSH response to TRH and haloperidol response latency in psychoses. 61
3136807 1988
33
[Independence of the slowly progressive form of schizophrenia]. 61
7010849 1980
34
Chronic cerebellar stimulation in the modulation of behavior. 61
6807046 1980
35
Schizophrenia .7. Group treatment of the acute and chronic patient. 61
1129154 1975

Variations for Schizophrenia 7

Expression for Schizophrenia 7

Search GEO for disease gene expression data for Schizophrenia 7.

Pathways for Schizophrenia 7

GO Terms for Schizophrenia 7

Cellular components related to Schizophrenia 7 according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 postsynaptic membrane GO:0045211 9.13 GRIN2D GRIN1 GABBR2
2 NMDA selective glutamate receptor complex GO:0017146 8.62 GRIN2D GRIN1

Biological processes related to Schizophrenia 7 according to GeneCards Suite gene sharing:

(showing 6, show less)
# Name GO ID Score Top Affiliating Genes
1 calcium-mediated signaling GO:0019722 9.37 GRIN2D GRIN1
2 excitatory postsynaptic potential GO:0060079 9.32 GRIN2D GRIN1
3 regulation of synaptic plasticity GO:0048167 9.26 GRIN2D GRIN1
4 ionotropic glutamate receptor signaling pathway GO:0035235 9.16 GRIN2D GRIN1
5 excitatory chemical synaptic transmission GO:0098976 8.96 GRIN2D GRIN1
6 calcium ion transmembrane import into cytosol GO:0097553 8.62 GRIN2D GRIN1

Molecular functions related to Schizophrenia 7 according to GeneCards Suite gene sharing:

(showing 4, show less)
# Name GO ID Score Top Affiliating Genes
1 ligand-gated ion channel activity GO:0015276 9.26 GRIN2D GRIN1
2 ionotropic glutamate receptor activity GO:0004970 9.16 GRIN2D GRIN1
3 NMDA glutamate receptor activity GO:0004972 8.96 GRIN2D GRIN1
4 glutamate-gated calcium ion channel activity GO:0022849 8.62 GRIN2D GRIN1

Sources for Schizophrenia 7

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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