SCZD8
MCID: SCH084
MIFTS: 27

Schizophrenia 8 (SCZD8)

Categories: Ear diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Schizophrenia 8

MalaCards integrated aliases for Schizophrenia 8:

Name: Schizophrenia 8 57 12 15 70
Schizophrenia Susceptibility Locus, Chromosome 18-Related 57 13
Sczd8 57 12
Schizophrenia 8 with or Without an Affective Disorder 57

Classifications:



External Ids:

Disease Ontology 12 DOID:0070084
OMIM® 57 603206
MedGen 41 C1864124
UMLS 70 C1864124

Summaries for Schizophrenia 8

Disease Ontology : 12 A schizophrenia that has material basis in an autosomal dominant mutation of SCZD8 on chromosome 18p.

MalaCards based summary : Schizophrenia 8, also known as schizophrenia susceptibility locus, chromosome 18-related, is related to schizophrenia and depression. An important gene associated with Schizophrenia 8 is SCZD8 (Schizophrenia Disorder 8), and among its related pathways/superpathways is Chromatin Regulation / Acetylation. Affiliated tissues include brain, cortex and amygdala, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

More information from OMIM: 603206

Related Diseases for Schizophrenia 8

Graphical network of the top 20 diseases related to Schizophrenia 8:



Diseases related to Schizophrenia 8

Symptoms & Phenotypes for Schizophrenia 8

Clinical features from OMIM®:

603206 (Updated 05-Apr-2021)

GenomeRNAi Phenotypes related to Schizophrenia 8 according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.44 CHD1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.44 CHD1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.44 CHD1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.44 CHD6
5 Increased shRNA abundance (Z-score > 2) GR00366-A-15 9.44 CHD6
6 Increased shRNA abundance (Z-score > 2) GR00366-A-17 9.44 CHD6
7 Increased shRNA abundance (Z-score > 2) GR00366-A-179 9.44 CHD1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-187 9.44 CHD1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.44 CHD6
10 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.44 CHD6
11 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.44 CHD1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.44 CHD6
13 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.44 CHD1

MGI Mouse Phenotypes related to Schizophrenia 8:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 8.8 CHD1 CHD4 CHD6

Drugs & Therapeutics for Schizophrenia 8

Search Clinical Trials , NIH Clinical Center for Schizophrenia 8

Genetic Tests for Schizophrenia 8

Anatomical Context for Schizophrenia 8

MalaCards organs/tissues related to Schizophrenia 8:

40
Brain, Cortex, Amygdala

Publications for Schizophrenia 8

Articles related to Schizophrenia 8:

(show all 34)
# Title Authors PMID Year
1
Alternative transcripts and evidence of imprinting of GNAL on 18p11.2. 57
16044173 2005
2
Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis. 57
9758604 1998
3
Searching for susceptibility genes in schizophrenia by genetic linkage analysis. 57
9246509 1996
4
Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. 57
8533768 1995
5
Synchronous patchy pattern of gene expression for adenylyl cyclase and phosphodiesterase but discrete expression for G-protein in developing rat striatum. 57
8750876 1995
6
A continuum of psychosis, one human gene, and not much else--the case for homogeneity. 57
8562488 1995
7
Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. 57
8016089 1994
8
G(olf) and Gs in rat basal ganglia: possible involvement of G(olf) in the coupling of dopamine D1 receptor with adenylyl cyclase. 57
8478697 1993
9
ALDH4A1 expression levels are elevated in postmortem brains of patients with schizophrenia and are associated with genetic variants in enzymes related to proline metabolism. 61
32065947 2020
10
Meta-Analysis of Cognitive Performance in Neurodevelopmental Disorders during Adulthood: Comparisons between Autism Spectrum Disorder and Schizophrenia on the Wechsler Adult Intelligence Scales. 61
32273855 2020
11
Feasibility of remotely supervised transcranial direct current stimulation and cognitive remediation: A systematic review. 61
32092069 2020
12
Hippocampal volume and cell number in depression, schizophrenia, and suicide subjects. 61
31715144 2020
13
[Depression in relatives of patients with schizophrenia: 8-month longitudinal outcome of ProFamille Program]. 61
28073465 2018
14
Mild Cognitive Impairment in Rural Tanzania: Prevalence, Profile, and Outcomes at 4-Year Follow-up. 61
25579049 2015
15
Circuit- and Diagnosis-Specific DNA Methylation Changes at γ-Aminobutyric Acid-Related Genes in Postmortem Human Hippocampus in Schizophrenia and Bipolar Disorder. 61
25738424 2015
16
One-year follow-up study of psychotic patients treated with blonanserin: a case series. 61
23857800 2013
17
A morphometric analysis of the septal nuclei in schizophrenia and affective disorders: reduced neuronal density in the lateral septal nucleus in bipolar disorder. 61
20607547 2011
18
Levels of neuregulin 1 and 3 proteins in Brodmann's area 46 from subjects with schizophrenia and bipolar disorder. 61
19765633 2009
19
Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins. 61
19051289 2009
20
Reward feedback alterations in unmedicated schizophrenia patients: relevance for delusions. 61
19195646 2009
21
Short-term treatment with risperidone or haloperidol in first-episode schizophrenia: 8-week results of a randomized controlled trial within the German Research Network on Schizophrenia. 61
18466670 2008
22
Reduced word-repetition effect in the event-related potentials of thought-disordered patients with schizophrenia. 61
15892981 2005
23
Electroconvulsive therapy in Belgium: a questionnaire study on the practice of electroconvulsive therapy in Flanders and the Brussels Capital region. 61
15791169 2005
24
Decreased 5-HT1A receptor binding in amygdala of schizophrenia. 61
15023569 2004
25
Quality of life in schizophrenia: a grounded theory approach. 61
12952542 2003
26
Neuritic pathology is lacking in the entorhinal cortex, subiculum and hippocampus in middle-aged adults with schizophrenia, bipolar disorder or unipolar depression. 61
11935265 2002
27
Differential alteration of phospholipase A2 activities in brain of patients with schizophrenia. 61
10064828 1999
28
MMPI manifestations of Chinese migraine syndromes: a control study. 61
10354815 1999
29
[The clinical characteristics of endogenous mental diseases with paroxysm-like disorders]. 61
9245152 1997
30
Neurologic abnormalities in murderers. 61
7675220 1995
31
Obsessive compulsive disorder with psychotic features. 61
8262879 1993
32
[Anamnesis of adolescent schizophrenics. A contribution on the problem of the etiology of schizophrenia]. 61
2409587 1985
33
Ego function assessment of schizo-affective patients as compared to schizophrenic and affective psychotic patients. 61
6622734 1983
34
Schizophrenia .8. From hospital to community. 61
1129165 1975

Variations for Schizophrenia 8

Expression for Schizophrenia 8

Search GEO for disease gene expression data for Schizophrenia 8.

Pathways for Schizophrenia 8

Pathways related to Schizophrenia 8 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.21 CHD8 CHD4 CHD1

GO Terms for Schizophrenia 8

Biological processes related to Schizophrenia 8 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin organization GO:0006325 9.26 CHD8 CHD6 CHD4 CHD1
2 ATP-dependent chromatin remodeling GO:0043044 9.16 CHD8 CHD4
3 DNA duplex unwinding GO:0032508 8.92 CHD8 CHD6 CHD4 CHD1

Molecular functions related to Schizophrenia 8 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.76 CHD8 CHD6 CHD4 CHD1
2 nucleotide binding GO:0000166 9.73 CHD8 CHD6 CHD4 CHD1
3 hydrolase activity GO:0016787 9.71 CHD8 CHD6 CHD4 CHD1
4 ATP binding GO:0005524 9.62 CHD8 CHD6 CHD4 CHD1
5 methylated histone binding GO:0035064 9.37 CHD8 CHD1
6 DNA-dependent ATPase activity GO:0008094 9.26 CHD8 CHD6
7 helicase activity GO:0004386 9.26 CHD8 CHD6 CHD4 CHD1
8 hydrolase activity, acting on acid anhydrides GO:0016817 9.16 CHD8 CHD6
9 DNA helicase activity GO:0003678 8.92 CHD8 CHD6 CHD4 CHD1

Sources for Schizophrenia 8

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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