SCZD9
MCID: SCH073
MIFTS: 21

Schizophrenia 9 (SCZD9)

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Schizophrenia 9

MalaCards integrated aliases for Schizophrenia 9:

Name: Schizophrenia 9 58 12 76 30 15 74
Sczd9 58 12 76
Schizophrenia 9, Susceptibility to 58 6
Schizophrenia Susceptibility Locus, Chromosome 1q42-Related 58
Schizophrenia Susceptibility Locus Chromosome 1q-Related 76
Schizophrenia 9 with or Without an Affective Disorder 58
Schizophrenia, Type 9 41

Classifications:



External Ids:

Disease Ontology 12 DOID:0070085
OMIM 58 604906
MeSH 45 D012559
MedGen 43 C1858050
UMLS 74 C1858050

Summaries for Schizophrenia 9

UniProtKB/Swiss-Prot : 76 Schizophrenia 9: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.

MalaCards based summary : Schizophrenia 9, also known as sczd9, is related to schizophrenia. An important gene associated with Schizophrenia 9 is DISC1 (DISC1 Scaffold Protein).

Disease Ontology : 12 A schizophrenia that has material basis in a mutation of DISC1 on chromosome 1q42.2.

Description from OMIM: 604906

Related Diseases for Schizophrenia 9

Diseases in the Schizophrenia family:

Schizophrenia 1 Schizophrenia 3
Schizophrenia 4 Schizophrenia 6
Schizophrenia 5 Schizophrenia 7
Schizophrenia 8 Schizophrenia 2
Schizophrenia 9 Schizophrenia 10
Schizophrenia 11 Schizophrenia 12
Schizophrenia 14 Schizophrenia 13
Schizophrenia 15 Schizophrenia 16
Schizophrenia 18 Schizophrenia 19
Early-Onset Schizophrenia

Diseases related to Schizophrenia 9 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 schizophrenia 9.5 DISC1 SYN3

Symptoms & Phenotypes for Schizophrenia 9

Clinical features from OMIM:

604906

Drugs & Therapeutics for Schizophrenia 9

Search Clinical Trials , NIH Clinical Center for Schizophrenia 9

Genetic Tests for Schizophrenia 9

Genetic tests related to Schizophrenia 9:

# Genetic test Affiliating Genes
1 Schizophrenia 9 30 DISC1

Anatomical Context for Schizophrenia 9

Publications for Schizophrenia 9

Articles related to Schizophrenia 9:

# Title Authors Year
1
Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. ( 17984054 )
2007
2
A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia. ( 16103888 )
2005
3
Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. ( 15386212 )
2004
4
Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects. ( 14532331 )
2003

Variations for Schizophrenia 9

ClinVar genetic disease variations for Schizophrenia 9:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 DISC1 DISC1, HAPLOTYPE, HEP3 undetermined variant risk factor

Expression for Schizophrenia 9

Search GEO for disease gene expression data for Schizophrenia 9.

Pathways for Schizophrenia 9

GO Terms for Schizophrenia 9

Cellular components related to Schizophrenia 9 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.16 DISC1 SYN3
2 synapse GO:0045202 8.96 DISC1 SYN3
3 postsynaptic density GO:0014069 8.62 DISC1 SYN3

Sources for Schizophrenia 9

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....