MCID: SCH011
MIFTS: 36

Schizotypal Personality Disorder

Categories: Mental diseases

Aliases & Classifications for Schizotypal Personality Disorder

MalaCards integrated aliases for Schizotypal Personality Disorder:

Name: Schizotypal Personality Disorder 12 73 54 44 15 70
Schizotypal Personality 54

Classifications:



External Ids:

Disease Ontology 12 DOID:10646
ICD9CM 34 301.22
MeSH 44 D012569
NCIt 50 C92632
SNOMED-CT 67 231486008
ICD10 32 F21
UMLS 70 C0036363

Summaries for Schizotypal Personality Disorder

Disease Ontology : 12 A personality disorder that involves a need for social isolation, anxiety in social situations, odd behavior and thinking, and often unconventional beliefs.

MalaCards based summary : Schizotypal Personality Disorder, also known as schizotypal personality, is related to personality disorder and post-traumatic stress disorder. An important gene associated with Schizotypal Personality Disorder is COMT (Catechol-O-Methyltransferase). The drugs Guanfacine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and caudate nucleus, and related phenotype is behavior/neurological.

Wikipedia : 73 Schizotypal personality disorder (STPD), also known as schizotypal disorder, is a personality disorder... more...

Related Diseases for Schizotypal Personality Disorder

Diseases related to Schizotypal Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 personality disorder 32.0 HTR2A COMT CACNA1C
2 post-traumatic stress disorder 30.4 NRG1 HTR2A COMT
3 cannabis abuse 30.3 PRODH NRG1 COMT
4 obsessive-compulsive personality disorder 30.1 HTR2A COMT
5 cannabis dependence 30.1 NRG1 COMT
6 substance abuse 30.1 PRODH HTR2A COMT
7 tic disorder 30.1 PRODH HTR2A COMT
8 mental depression 30.0 PRODH HTR2A DISC1 COMT CACNA1C
9 anxiety 29.7 PRODH HTR2A DISC1 COMT
10 major depressive disorder 29.7 ZNF804A HTR2A DTNBP1 DISC1 COMT CACNA1C
11 autism spectrum disorder 29.7 ZNF804A PRODH NRG1 HTR2A DISC1 COMT
12 autism 29.4 ZNF804A PRODH NRG1 HTR2A DTNBP1 DISC1
13 bipolar i disorder 29.1 ZNF804A NRG1 HTR2A DTNBP1 DAO COMT
14 schizophreniform disorder 28.4 ZNF804A PRODH NRG1 HTR2A DTNBP1 DISC1
15 schizoaffective disorder 28.3 SULT4A1 RGS4 PRODH HTR2A DTNBP1 DISC1
16 psychotic disorder 28.2 ZNF804A RGS4 PRODH NRG1 HTR2A DTNBP1
17 schizophrenia 27.8 ZNF804A SULT4A1 RGS4 PSAT1 PRODH NRG1
18 bipolar disorder 27.6 ZNF804A RGS4 PRODH NRG1 HTR2A DTNBP1
19 disease of mental health 27.6 ZNF804A RGS4 PRODH NRG1 HTR2A DTNBP1
20 avoidant personality disorder 10.9
21 borderline personality disorder 10.6
22 obsessive-compulsive disorder 10.5
23 severe combined immunodeficiency 10.5
24 hand skill, relative 10.4
25 digeorge syndrome 10.2
26 anorexia nervosa 10.2
27 schizophrenia 9 10.2 PRODH DISC1
28 attention deficit-hyperactivity disorder 10.1
29 schizophrenia 2 10.1 PRODH DISC1
30 schizoid personality disorder 10.1 ZNF804A PRODH DISC1
31 tardive dyskinesia 10.1 HTR2A COMT
32 conversion disorder 10.1 HTR2A COMT
33 intermittent explosive disorder 10.1 HTR2A COMT
34 bestiality 10.1 HTR2A COMT
35 fragile x syndrome 10.1
36 frontotemporal dementia 10.1
37 major affective disorder 8 10.1
38 major affective disorder 9 10.1
39 schizophrenia 13 10.1
40 schizophrenia 19 10.1
41 alexithymia 10.1
42 paranoid personality disorder 10.1
43 depersonalization disorder 10.1
44 conduct disorder 10.1
45 toxic shock syndrome 10.1
46 generalized anxiety disorder 10.1
47 severe acute respiratory syndrome 10.1
48 mutism 10.1
49 pneumonia 10.1
50 acute stress disorder 10.1

Graphical network of the top 20 diseases related to Schizotypal Personality Disorder:



Diseases related to Schizotypal Personality Disorder

Symptoms & Phenotypes for Schizotypal Personality Disorder

MGI Mouse Phenotypes related to Schizotypal Personality Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.36 CACNA1C COMT DAO DISC1 DTNBP1 HTR2A

Drugs & Therapeutics for Schizotypal Personality Disorder

Drugs for Schizotypal Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
2 Neurotransmitter Agents Phase 4
3 Adrenergic alpha-Agonists Phase 4
4 Adrenergic Agonists Phase 4
5 Adrenergic Agents Phase 4
6 Antihypertensive Agents Phase 4
7
Dopamine Approved Phase 2 62-31-7, 51-61-6 681
8
Risperidone Approved, Investigational Phase 1, Phase 2 106266-06-2 5073
9 Dihydrexidine Investigational Phase 2 123039-93-0
10 Dopamine Agents Phase 2
11 Dopamine agonists Phase 2
12 Psychotropic Drugs Phase 1, Phase 2
13 Antipsychotic Agents Phase 1, Phase 2
14 Dopamine Antagonists Phase 1, Phase 2
15
Serotonin Investigational, Nutraceutical Phase 1, Phase 2 50-67-9 5202
16
Oxytocin Approved, Vet_approved Phase 1 50-56-6 53477758 439302
17
Pergolide Approved, Investigational, Vet_approved, Withdrawn 66104-22-1 47811
18
Adenosine Approved, Investigational 58-61-7 60961
19
Benserazide Approved, Investigational Early Phase 1 322-35-0
20
Levodopa Approved Early Phase 1 59-92-7 6047
21 Dihydroxyphenylalanine Early Phase 1
22 Benserazide, levodopa drug combination Early Phase 1
23 Antiparkinson Agents Early Phase 1

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Pharmacology of Cognition in Schizotypal Personality Disorder: Guanfacine for Cognitive Symptoms in Schizotypal Personality Disorder Terminated NCT00353379 Phase 4 Guanfacine;Placebo
2 Clinical Testing of a D1 Agonist for Cognitive Enhancement in Schizotypal Personality Disorder Unknown status NCT01466205 Phase 2 DAR-0100A;Placebo
3 A D1 Agonist For Working Memory Enhancement In The Schizophrenia Spectrum Completed NCT02507206 Phase 2 DAR 0-100A;Placebo
4 Schizotypal Personality Disorder Risperidone Completed NCT02535156 Phase 1, Phase 2 Risperidone;Placebo
5 Guanfacine Enhancement of Working Memory: Prospects for Augmenting Cognitive Remediation in the Schizophrenia Spectrum Completed NCT02524899 Phase 2 Guanfacine;Placebo
6 Examining Dose-Related Effects of Oxytocin on Social Cognition Across Populations Suspended NCT02149823 Phase 1 Syntocinon 24 Intranasal Units (IU);Syntocinon 40 Intranasal Units (IU);Intranasal Placebo
7 The Dopaminergic System in Schizotypal Personality Disorder: Pergolide for Cognitive Symptoms in Schizotypal Personality Disorder Unknown status NCT00252044 Pergolide
8 Psychopathological Differences Between Asperger Syndrome/Normal IQ, no Language Impairment Autism Spectrum Disorder and Schizotypal Disorder in an Adult Sample Completed NCT02800681
9 Risperidone in the Treatment of Psychotic-like and Deficit Symptoms of Schizotypal Personality Disorder Completed NCT00158028 Risperidone;Placebo
10 A Psychopathological Study of Latent (Early) Schizophrenia: Clinical Pathology/Neuropsychological Dysfunctions Completed NCT00155519
11 L-Dopa Modulated Striatal Functional Connectivity in Schizotypal Adults: a Randomized Double-blind Placebo-controlled Study Completed NCT03333369 Early Phase 1 200 mg levodopa/50 mg benserazide;Dextrose
12 Compassion and Metacognition Based Therapy for Schizotypal Personality Disorder: A Pilot Non-inferiority Randomized Controlled Trial on Repeated Measures. Recruiting NCT04764708
13 Real or Concieved Death Number Perception in Depression, Anxiety and in Schizotypal Personality Disorder Following Covid-19 Pandemic Lockdown Recruiting NCT04384419
14 Childhood Trauma in Schizophrenia: Exploration of Links Between Gene Expression, Cerebral Morphology and Symptomatology. SCHIZO' TRAUMA Recruiting NCT03355781
15 Randomised Clinical Trial of Integrated Treatment Versus Standard Treatment in First Episode Psychosis Active, not recruiting NCT00157313

Search NIH Clinical Center for Schizotypal Personality Disorder

Cochrane evidence based reviews: schizotypal personality disorder

Genetic Tests for Schizotypal Personality Disorder

Anatomical Context for Schizotypal Personality Disorder

MalaCards organs/tissues related to Schizotypal Personality Disorder:

40
Brain, Eye, Caudate Nucleus, Pituitary, Cortex, Temporal Lobe, Skin

Publications for Schizotypal Personality Disorder

Articles related to Schizotypal Personality Disorder:

(show top 50) (show all 1265)
# Title Authors PMID Year
1
Catechol-o-methyltransferase genotype and childhood trauma may interact to impact schizotypal personality traits. 61 54
20033274 2010
2
A quantitative association study between schizotypal traits and COMT, PRODH and BDNF genes in a healthy Chinese population. 61 54
17604122 2007
3
Schizotypal dimensions: an intermediate phenotype associated with the COMT high activity allele. 54 61
17034018 2007
4
Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups. 54 61
16691129 2006
5
Do schizotypy features predict cannabis problems in partnered community adults? 61
33465724 2021
6
Self-perceived cognitive lapses and psychological well-being in schizotypy: Generalized and domain-specific associations. 61
33373062 2021
7
The effect of effort-reward imbalance on brain structure and resting-state functional connectivity in individuals with high levels of schizotypal traits. 61
33706673 2021
8
Linking narrative identity with schizotypal personality disorder features in adolescents. 61
32567868 2021
9
The Schizotypal Personality Questionnaire for Children (SPQ-C): Factor Structure, Child Abuse, and Family History of Schizotypy. 61
32674122 2021
10
Subclinical schizotypal vs. autistic traits show overlapping and diametrically opposed facets in a non-clinical population. 61
33744683 2021
11
Treatment of catatonia with asenapine in a patient with schizotypal personality disorder, psychotic depression and septic shock from SARS-CoV-2 - A case report. 61
33634761 2021
12
The Relationship Between Multisensory Temporal Processing and Schizotypal Traits. 61
33706260 2021
13
Attenuated Resting-State Functional Anticorrelation between Attention and Executive Control Networks in Schizotypal Personality Disorder. 61
33467694 2021
14
Early life factors of schizotypal personality disorder in adolescents: A systematic review. 61
33502097 2021
15
Positive schizotypy, maladaptive openness, and openness facets. 61
32584093 2021
16
Neural Correlates of Schizotypal Personality Disorder: a Systematic Review of Neuroimaging and EEG Studies. 61
33459241 2021
17
Does variation in trait schizotypy and frequency of cannabis use influence the acute subjective, cognitive and psychotomimetic effects of delta-9-tetrahydrocannabinol? A mega-analysis. 61
33427016 2021
18
Schizotypy, neuroticism, and saccadic eye movements: New data and meta-analysis. 61
33095460 2021
19
The Self in the Spectrum: A Meta-analysis of the Evidence Linking Basic Self-Disorders and Schizophrenia. 61
33479736 2021
20
Examination of the Prefrontal Cortex Hemodynamic Responses to the Fist-Edge-Palm Task in Naïve Subjects Using Functional Near-Infrared Spectroscopy. 61
33633554 2021
21
Self-reported sensory responsiveness patterns in typically-developing and early-onset schizophrenia adolescents: Its relationship with schizotypal and autistic traits. 61
33035958 2020
22
Exploring schizophrenia spectrum psychopathology in borderline personality disorder. 61
31289925 2020
23
Schizophrenia-spectrum psychopathology in obsessive-compulsive disorder: an empirical study. 61
31129700 2020
24
Assessment and treatment planning for schizotypal personality disorder: A metacognitively oriented point of view. 61
32463252 2020
25
Schizotypal traits are not related to multisensory integration or audiovisual speech perception. 61
33120291 2020
26
Extending schizophrenia diagnostic model to predict schizotypy in first-degree relatives. 61
33159092 2020
27
Schizotypy and help-seeking for anxiety. 61
33242926 2020
28
Psychometric Properties of the Schizotypal Personality Questionnaire (SPQ) in a Mexican Population: Invariance Across Gender and Age. 61
33073762 2020
29
Characterizing psychosis-relevant phenomena and cognitive function in a unique population with isolated, chronic and very heavy cannabis exposure. 61
31615592 2020
30
Schizotypal and obsessive-compulsive traits: Co-occurrence rate and relationship with executive function, emotion experience, and emotion expressivity in college students. 61
32677322 2020
31
The association of striatal volume and positive schizotypy in healthy subjects: intelligence as a moderating factor. 61
31530329 2020
32
Grey matter volume and structural covariance associated with schizotypy. 61
33046333 2020
33
Resting frontal EEG asymmetry and schizotypal traits: a test-retest study. 61
32731803 2020
34
Emotion Regulation and Depressive Symptoms Mediate the Association Between Schizotypal Personality Traits and Suicidality in Chinese College Students. 61
32924826 2020
35
Neuropsychological profile of children and adolescents with psychosis risk syndrome: the CAPRIS study. 61
31897849 2020
36
A Dual Therapeutic Setting Model Experience for Schizotypal Personality Disorder in an Inpatient Unit. 61
32890389 2020
37
Amphetamine-induced striatal dopamine release in schizotypal personality disorder. 61
32572588 2020
38
Anhedonia in young people with first episode psychosis: a longitudinal study. 61
32108539 2020
39
Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms. 61
32315977 2020
40
Exploring the Relationship Between Schizotypal Traits and Dispositional Mindfulness From a Network Perspective. 61
32229789 2020
41
Schizotypal personality disorder in clinical obsessive-compulsive disorder samples: a brief overview. 61
32713392 2020
42
A common variant of the NOTCH4 gene modulates functional connectivity of the occipital cortex and its relationship with schizotypal traits. 61
32646407 2020
43
The association of schizotypal traits with Prepulse Inhibition: a double approach exploration. 61
32539604 2020
44
Relationship between religiosity domains and traits from borderline and schizotypal personality disorders in a Brazilian community sample. 61
33084801 2020
45
Co-occurring opioid and sedative use disorder: Gender differences in use patterns and psychiatric co-morbidities in the United States. 61
32527509 2020
46
Multivariate patterns of gray matter volume in thalamic nuclei are associated with positive schizotypy in healthy individuals. 61
31358071 2020
47
Associations between schizotypal personality features, mentalizing difficulties and thought problems in a sample of community adolescents. 61
32573985 2020
48
Does cannabis use predict psychometric schizotypy via aberrant salience? 61
32273148 2020
49
Emerging 5-HT receptor antagonists for the treatment of Schizophrenia. 61
32449404 2020
50
Excitation-inhibition balance and auditory multistable perception are correlated with autistic traits and schizotypy in a non-clinical population. 61
32424307 2020

Variations for Schizotypal Personality Disorder

Expression for Schizotypal Personality Disorder

Search GEO for disease gene expression data for Schizotypal Personality Disorder.

Pathways for Schizotypal Personality Disorder

GO Terms for Schizotypal Personality Disorder

Cellular components related to Schizotypal Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.03 ZNF804A TUBGCP4 SULT4A1 RGS4 PSAT1 NRG1
2 synapse GO:0045202 9.35 NRG1 HTR2A DTNBP1 DISC1 CACNA1C
3 dendritic spine GO:0043197 9.33 ZNF804A DTNBP1 COMT
4 axon GO:0030424 9.1 ZNF804A NRG1 HTR2A DTNBP1 DISC1 COMT

Biological processes related to Schizotypal Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of dopamine secretion GO:0014059 8.96 HTR2A DTNBP1
2 proline catabolic process GO:0006562 8.62 PRODH DAO

Molecular functions related to Schizotypal Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein alpha-subunit binding GO:0001965 8.62 RGS4 HTR2A

Sources for Schizotypal Personality Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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