MCID: SCH010
MIFTS: 35

Schneiderian Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Schneiderian Carcinoma

MalaCards integrated aliases for Schneiderian Carcinoma:

Name: Schneiderian Carcinoma 12 15 73
Cylindrical Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4003
NCIt 50 C54287
SNOMED-CT 68 5600009
UMLS 73 C0334270

Summaries for Schneiderian Carcinoma

MalaCards based summary : Schneiderian Carcinoma, also known as cylindrical cell carcinoma, is related to paranasal sinus cancer and conventional angiosarcoma, and has symptoms including pain and rhinorrhea. An important gene associated with Schneiderian Carcinoma is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Signaling by NOTCH1. Affiliated tissues include liver, tonsil and kidney, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Schneiderian Carcinoma

Diseases related to Schneiderian Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 paranasal sinus cancer 10.2 MAML2 SOX4
2 conventional angiosarcoma 10.1 MAML2 SYP
3 lymphoepithelioma-like thymic carcinoma 10.1 KRT18 KRT5
4 odontoma 10.1 KRT18 KRT5
5 breast papillary carcinoma 10.1 KRT5 SYP
6 lymphoepithelioma-like carcinoma 10.1 KRT18 KRT5
7 sensory organ benign neoplasm 10.1 KRT5 SYP
8 pineal gland cancer 10.1 KRT18 SYP
9 middle ear adenoma 10.1 KRT5 SYP
10 seminal vesicle tumor 10.1 KRT18 SYP
11 papillary ependymoma 10.1 KRT18 SYP
12 gastric squamous cell carcinoma 10.1 KRT5 SYP
13 intraneural perineurioma 10.1 KRT18 KRT5
14 tonsil cancer 10.1 KRT5 MAML2
15 atypical choroid plexus papilloma 10.1 KRT5 SYP
16 optic nerve neoplasm 10.0 KRT5 SYP
17 carcinoid tumors, intestinal 10.0 NOTCH1 SYP
18 lacrimal gland mucoepidermoid carcinoma 10.0 CRTC1 MAML2
19 cutaneous mucoepidermoid carcinoma 10.0 CRTC1 MAML2
20 breast mucoepidermoid carcinoma 10.0 CRTC1 MAML2
21 clear cell hidradenoma 10.0 CRTC1 MAML2
22 cervical clear cell adenocarcinoma 10.0 KRT18 KRT5 SYP
23 hypoplastic right heart syndrome 10.0 NOTCH1 RBL2
24 sweat gland cancer 10.0 KRT18 KRT5 SYP
25 endodermal sinus tumor 10.0
26 polycystic liver disease 1 with or without kidney cysts 10.0
27 aspergillosis 10.0
28 liver disease 10.0
29 small cell carcinoma 10.0
30 polycystic liver disease 10.0
31 papilloma 10.0
32 inverted papilloma 10.0
33 in situ carcinoma 10.0
34 sinonasal undifferentiated carcinoma 10.0
35 spindle cell carcinoma 9.9 KRT5 SYP
36 adenoid cystic carcinoma 9.9 KRT5 NOTCH1 SOX4
37 primary cutaneous amyloidosis 9.9 KRT18 KRT5
38 warthin tumor 9.9 CRTC1 KRT18 MAML2
39 lipoadenoma 9.9 CRTC1 KRT5 MAML2
40 necrotizing sialometaplasia 9.9 CRTC1 KRT5 MAML2
41 oropharynx cancer 9.9 CRTC1 KRT5 MAML2
42 salivary gland disease 9.9 CRTC1 MAML2
43 human t-cell leukemia virus type 1 9.9 CRTC1 EP300
44 cervical adenosquamous carcinoma 9.8 CRTC1 MAML2 NOTCH1

Graphical network of the top 20 diseases related to Schneiderian Carcinoma:



Diseases related to Schneiderian Carcinoma

Symptoms & Phenotypes for Schneiderian Carcinoma

UMLS symptoms related to Schneiderian Carcinoma:


pain, rhinorrhea

GenomeRNAi Phenotypes related to Schneiderian Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.4 EP300
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.4 EP300 NOTCH1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.4 SOX4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.4 SOX4
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.4 NOTCH1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.4 EP300 NOTCH1 SOX4
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.4 EP300 SOX4
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.4 NOTCH1

MGI Mouse Phenotypes related to Schneiderian Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.98 DLK1 EP300 GAS6 MAML3 NOTCH1 RBL2
2 growth/size/body region MP:0005378 9.97 CRTC1 DLK1 EP300 KRT18 KRT5 MAML3
3 embryo MP:0005380 9.91 DLK1 EP300 KRT18 MAML3 NOTCH1 RBL2
4 mortality/aging MP:0010768 9.91 DLK1 EP300 GAS6 KRT18 KRT5 MAML3
5 craniofacial MP:0005382 9.88 EP300 KRT5 MAML3 NOTCH1 RBL2 SOX4
6 normal MP:0002873 9.63 EP300 MAML3 NOTCH1 RBL2 SOX4 SYP
7 renal/urinary system MP:0005367 9.35 EP300 GAS6 NOTCH1 RBL2 SOX4
8 vision/eye MP:0005391 9.1 DLK1 EP300 GAS6 NOTCH1 RBL2 SOX4

Drugs & Therapeutics for Schneiderian Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy Recruiting NCT01586767 Not Applicable

Search NIH Clinical Center for Schneiderian Carcinoma

Genetic Tests for Schneiderian Carcinoma

Anatomical Context for Schneiderian Carcinoma

MalaCards organs/tissues related to Schneiderian Carcinoma:

41
Liver, Tonsil, Kidney, Heart, T Cells, Pineal, Salivary Gland

Publications for Schneiderian Carcinoma

Articles related to Schneiderian Carcinoma:

(show all 11)
# Title Authors Year
1
Whole-Exome Sequencing of Sinonasal Small Cell Carcinoma Arising within a Papillary Schneiderian Carcinoma In Situ. ( 29734873 )
2018
2
Low-Grade Papillary Schneiderian Carcinoma: A Case Report. ( 28639124 )
2018
3
Low-Grade Papillary Schneiderian Carcinoma of the Sinonasal Cavity and Temporal Bone. ( 30269519 )
2018
4
Hepatobiliary and Pancreatic: A unique case of HPV related metastatic Schneiderian carcinoma presenting as polycystic liver disease. ( 28052462 )
2017
5
Low-grade Papillary Schneiderian Carcinoma, a Unique and Deceptively Bland Malignant Neoplasm: Report of a Case. ( 25634744 )
2015
6
Exophytic schneiderian carcinoma of the lacrimal sac: first case report. ( 24977732 )
2014
7
Schneiderian carcinoma developing in an inverted papilloma of the palatine tonsil: an unusual case. ( 21563078 )
2011
8
Sinonasal undifferentiated carcinoma, or schneiderian carcinoma arising from an aspergillosis: a case history. ( 19211176 )
2009
9
Prevalence of high-risk human papillomavirus DNA in nonkeratinizing (cylindrical cell) carcinoma of the sinonasal tract: a distinct clinicopathologic and molecular disease entity. ( 16160480 )
2005
10
Cylindrical-cell carcinoma of the nose. ( 14923304 )
1952
11
Primary Gelatinous Cylindrical Cell Carcinoma of the Lung. ( 19969689 )
1926

Variations for Schneiderian Carcinoma

Expression for Schneiderian Carcinoma

Search GEO for disease gene expression data for Schneiderian Carcinoma.

Pathways for Schneiderian Carcinoma

Pathways related to Schneiderian Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 EP300 MAML2 MAML3 NOTCH1 RBL2
2
Show member pathways
12.5 DLK1 EP300 MAML2 MAML3 NOTCH1
3
Show member pathways
12.19 DLK1 EP300 MAML2 MAML3 NOTCH1
4 11.89 DLK1 MAML2 NOTCH1
5
Show member pathways
11.56 EP300 MAML2 MAML3 NOTCH1
6
Show member pathways
11.51 DLK1 EP300 MAML2 MAML3 NOTCH1
7 11.4 EP300 MAML3 NOTCH1
8 11.18 EP300 MAML2 NOTCH1
9 10.36 DLK1 MAML2 MAML3 NOTCH1

GO Terms for Schneiderian Carcinoma

Cellular components related to Schneiderian Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.17 CRTC1 EP300 MAML2 MAML3 NOTCH1 RBL2

Biological processes related to Schneiderian Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.85 CRTC1 EP300 MAML2 MAML3 NOTCH1 SOX4
2 viral process GO:0016032 9.71 CRTC1 EP300 GAS6 KRT18
3 heart development GO:0007507 9.65 EP300 NOTCH1 SOX4
4 transcription initiation from RNA polymerase II promoter GO:0006367 9.61 MAML2 MAML3 NOTCH1
5 animal organ regeneration GO:0031100 9.49 GAS6 NOTCH1
6 ventricular septum morphogenesis GO:0060412 9.46 NOTCH1 SOX4
7 Notch signaling pathway GO:0007219 9.46 EP300 MAML2 MAML3 NOTCH1
8 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.43 EP300 RBL2 SOX4
9 negative regulation of biomineral tissue development GO:0070168 9.32 GAS6 NOTCH1
10 positive regulation of Notch signaling pathway GO:0045747 9.26 EP300 MAML2 MAML3 NOTCH1
11 positive regulation of transcription of Notch receptor target GO:0007221 8.92 EP300 MAML2 MAML3 NOTCH1

Molecular functions related to Schneiderian Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II activating transcription factor binding GO:0001102 8.96 EP300 RBL2
2 transcription coactivator activity GO:0003713 8.92 EP300 MAML2 MAML3 SOX4

Sources for Schneiderian Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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