MCID: SCH010
MIFTS: 37

Schneiderian Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Schneiderian Carcinoma

MalaCards integrated aliases for Schneiderian Carcinoma:

Name: Schneiderian Carcinoma 12 15 73
Cylindrical Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4003
NCIt 50 C54287
SNOMED-CT 68 5600009
UMLS 73 C0334270

Summaries for Schneiderian Carcinoma

MalaCards based summary : Schneiderian Carcinoma, also known as cylindrical cell carcinoma, is related to papilloma and paranasal sinus cancer, and has symptoms including pain and rhinorrhea. An important gene associated with Schneiderian Carcinoma is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Glioma. Affiliated tissues include tonsil and liver, and related phenotypes are Decreased BBC3 mRNA expression and Decreased CDKN1A mRNA expression

Related Diseases for Schneiderian Carcinoma

Diseases related to Schneiderian Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 papilloma 29.5 CDKN2A KRT5 TP53
2 paranasal sinus cancer 10.8 MAML2 SOX4
3 maxillary sinus cancer 10.8 MAML2 SOX4
4 odontoma 10.5 KRT18 KRT5
5 malignant spiradenoma 10.5 KRT5 TP53
6 vulvar intraepithelial neoplasia 10.5 KRT5 TP53
7 sarcomatoid squamous cell skin carcinoma 10.5 KRT5 TP53
8 lymphoepithelioma-like carcinoma 10.5 KRT18 KRT5
9 inverted transitional papilloma 10.5 CDKN2A KRT5
10 breast squamous cell carcinoma 10.4 KRT5 TP53
11 splenic diffuse red pulp small b-cell lymphoma 10.4 NOTCH1 TP53
12 tetraploidy 10.4 NOTCH1 TP53
13 microglandular adenosis 10.4 KRT18 TP53
14 invasive bladder transitional cell carcinoma 10.4 NOTCH1 TP53
15 optic nerve sheath meningioma 10.4 CDKN2A KRT5
16 pleomorphic carcinoma 10.4 KRT18 TP53
17 anal canal squamous cell carcinoma 10.3 CDKN2A KRT5
18 brain stem astrocytic neoplasm 10.3 CDKN2A TP53
19 epidural neoplasm 10.3 KRT5 TP53
20 spitz nevus 10.3 CDKN2A TP53
21 bladder carcinoma in situ 10.3 CDKN2A TP53
22 bartholin's gland benign neoplasm 10.3 CDKN2A TP53
23 vulva squamous cell carcinoma 10.3 CDKN2A TP53
24 thyroid lymphoma 10.3 CDKN2A TP53
25 nasal cavity adenocarcinoma 10.2 CDKN2A TP53
26 scrotal carcinoma 10.2 CDKN2A TP53
27 lacrimal gland mucoepidermoid carcinoma 10.2 CRTC1 MAML2
28 anal squamous cell carcinoma 10.2 CDKN2A TP53
29 prostate squamous cell carcinoma 10.2 KRT5 TP53
30 glycogen-rich clear cell breast carcinoma 10.2 CDKN2A TP53
31 gastric adenosquamous carcinoma 10.2 CDKN2A TP53
32 cutaneous mucoepidermoid carcinoma 10.2 CRTC1 MAML2
33 oral leukoplakia 10.2 CDKN2A TP53
34 anogenital venereal wart 10.2 CDKN2A TP53
35 megaesophagus 10.2 CDKN2A TP53
36 clear cell hidradenoma 10.2 CRTC1 MAML2
37 cervix uteri carcinoma in situ 10.2 CDKN2A TP53
38 adenosquamous carcinoma 10.2 KRT18 KRT5 TP53
39 mixed cell type cancer 10.2 KRT5 TP53
40 meningeal melanomatosis 10.1 CDKN2A TP53
41 dedifferentiated liposarcoma 10.1 CDKN2A TP53
42 suppressor of tumorigenicity 3 10.1 CDKN2A TP53
43 nasal cavity squamous cell carcinoma 10.1 CDKN2A KRT5
44 plasmablastic lymphoma 10.1 CDKN2A NOTCH1
45 cervical clear cell adenocarcinoma 10.1 CDKN2A KRT18 KRT5
46 oropharynx cancer 10.1 CDKN2A TP53
47 spinal cord astrocytoma 10.0 NOTCH1 TP53
48 endocervical adenocarcinoma 10.0 CDKN2A TP53
49 pleural cancer 10.0 CDKN2A KRT5
50 cholecystitis 10.0 CDKN2A KRT18 TP53

Graphical network of the top 20 diseases related to Schneiderian Carcinoma:



Diseases related to Schneiderian Carcinoma

Symptoms & Phenotypes for Schneiderian Carcinoma

UMLS symptoms related to Schneiderian Carcinoma:


pain, rhinorrhea

GenomeRNAi Phenotypes related to Schneiderian Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased BBC3 mRNA expression GR00389-S-3 8.96 TP53 EP300
2 Decreased CDKN1A mRNA expression GR00389-S-1 8.8 EP300 TP53
3 Decreased CDKN1A mRNA expression GR00389-S-2 8.8 TP53

MGI Mouse Phenotypes related to Schneiderian Carcinoma:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.22 CDKN2A EP300 CRTC1 DLK1 KRT18 MAML3
2 cardiovascular system MP:0005385 10.21 CDKN2A EP300 GAS6 DLK1 RBL2 MAML3
3 cellular MP:0005384 10.2 CDKN2A EP300 GAS6 DLK1 RBL2 MAML3
4 embryo MP:0005380 10.16 EP300 DLK1 KRT18 CDKN2A MAML3 NOTCH1
5 mortality/aging MP:0010768 10.11 CDKN2A EP300 GAS6 DLK1 KRT18 KRT5
6 homeostasis/metabolism MP:0005376 10.09 CDKN2A EP300 CRTC1 GAS6 DLK1 RBL2
7 craniofacial MP:0005382 10.08 EP300 KRT5 MAML3 NOTCH1 SOX4 RBL2
8 hematopoietic system MP:0005397 10.06 CDKN2A EP300 CRTC1 GAS6 DLK1 SOX4
9 endocrine/exocrine gland MP:0005379 10.04 CDKN2A EP300 CRTC1 RBL2 NOTCH1 SOX4
10 immune system MP:0005387 10.01 CDKN2A EP300 CRTC1 GAS6 DLK1 SOX4
11 digestive/alimentary MP:0005381 10 CDKN2A EP300 KRT5 NOTCH1 SOX4 TP53
12 muscle MP:0005369 9.8 CDKN2A EP300 DLK1 RBL2 NOTCH1 TP53
13 neoplasm MP:0002006 9.65 CDKN2A EP300 RBL2 NOTCH1 TP53
14 renal/urinary system MP:0005367 9.63 EP300 GAS6 RBL2 NOTCH1 SOX4 TP53
15 respiratory system MP:0005388 9.43 CDKN2A EP300 RBL2 NOTCH1 SOX4 TP53
16 vision/eye MP:0005391 9.23 CDKN2A EP300 GAS6 DLK1 NOTCH1 SOX4

Drugs & Therapeutics for Schneiderian Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy Active, not recruiting NCT01586767 Phase 2

Search NIH Clinical Center for Schneiderian Carcinoma

Genetic Tests for Schneiderian Carcinoma

Anatomical Context for Schneiderian Carcinoma

MalaCards organs/tissues related to Schneiderian Carcinoma:

41
Tonsil, Liver

Publications for Schneiderian Carcinoma

Articles related to Schneiderian Carcinoma:

# Title Authors Year
1
Whole-Exome Sequencing of Sinonasal Small Cell Carcinoma Arising within a Papillary Schneiderian Carcinoma In Situ. ( 29734873 )
2018
2
Hepatobiliary and Pancreatic: A unique case of HPV related metastatic Schneiderian carcinoma presenting as polycystic liver disease. ( 28052462 )
2017
3
Low-Grade Papillary Schneiderian Carcinoma: A Case Report. ( 28639124 )
2017
4
Low-grade Papillary Schneiderian Carcinoma, a Unique and Deceptively Bland Malignant Neoplasm: Report of a Case. ( 25634744 )
2015
5
Exophytic schneiderian carcinoma of the lacrimal sac: first case report. ( 24977732 )
2014
6
Schneiderian carcinoma developing in an inverted papilloma of the palatine tonsil: an unusual case. ( 21563078 )
2011
7
Sinonasal undifferentiated carcinoma, or schneiderian carcinoma arising from an aspergillosis: a case history. ( 19211176 )
2009

Variations for Schneiderian Carcinoma

Expression for Schneiderian Carcinoma

Search GEO for disease gene expression data for Schneiderian Carcinoma.

Pathways for Schneiderian Carcinoma

Pathways related to Schneiderian Carcinoma according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 EP300 MAML2 MAML3 NOTCH1 RBL2 TP53
2
Show member pathways
12.54 CDKN2A EP300 GAS6 NOTCH1 TP53
3
Show member pathways
12.54 DLK1 EP300 MAML2 MAML3 NOTCH1 TP53
4
Show member pathways
12.37 DLK1 EP300 MAML2 MAML3 NOTCH1
5 12.24 CDKN2A CRTC1 EP300 TP53
6 12.24 CDKN2A EP300 NOTCH1 SOX4 TP53
7 12.18 CDKN2A EP300 RBL2 TP53
8 12.1 CDKN2A EP300 RBL2 TP53
9 12.05 DLK1 MAML2 NOTCH1
10 11.99 CDKN2A RBL2 TP53
11 11.88 EP300 RBL2 TP53
12 11.87 CDKN2A EP300 TP53
13 11.82 EP300 NOTCH1 TP53
14 11.8 CDKN2A RBL2 TP53
15
Show member pathways
11.74 EP300 RBL2 TP53
16
Show member pathways
11.71 DLK1 EP300 MAML2 MAML3 NOTCH1
17 11.64 EP300 KRT5 TP53
18
Show member pathways
11.45 EP300 MAML2 MAML3 NOTCH1 TP53
19 11.42 CDKN2A EP300 TP53
20 11.38 EP300 MAML3 NOTCH1 TP53
21 11.31 EP300 MAML2 NOTCH1
22 10.94 CDKN2A TP53
23
Show member pathways
10.93 CDKN2A TP53
24 10.36 DLK1 MAML2 MAML3 NOTCH1

GO Terms for Schneiderian Carcinoma

Cellular components related to Schneiderian Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.7 CDKN2A CRTC1 EP300 KRT18 KRT5 MAML2
2 nucleoplasm GO:0005654 9.28 CDKN2A CRTC1 EP300 MAML2 MAML3 NOTCH1

Biological processes related to Schneiderian Carcinoma according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cell cycle GO:0007049 9.91 CDKN2A EP300 KRT18 RBL2 TP53
2 negative regulation of cell proliferation GO:0008285 9.88 CDKN2A NOTCH1 SOX4 TP53
3 positive regulation of transcription, DNA-templated GO:0045893 9.88 CDKN2A EP300 NOTCH1 SOX4 TP53
4 positive regulation of gene expression GO:0010628 9.86 CDKN2A EP300 GAS6 TP53
5 viral process GO:0016032 9.85 CRTC1 EP300 GAS6 KRT18 TP53
6 positive regulation of apoptotic process GO:0043065 9.84 CDKN2A NOTCH1 SOX4 TP53
7 transcription initiation from RNA polymerase II promoter GO:0006367 9.77 MAML2 MAML3 NOTCH1
8 protein stabilization GO:0050821 9.77 CDKN2A EP300 SOX4
9 positive regulation of transcription by RNA polymerase II GO:0045944 9.76 CDKN2A CRTC1 EP300 MAML2 MAML3 NOTCH1
10 rhythmic process GO:0048511 9.72 CRTC1 EP300 TP53
11 cell cycle arrest GO:0007050 9.71 CDKN2A GAS6 NOTCH1 TP53
12 Notch signaling pathway GO:0007219 9.62 EP300 MAML2 MAML3 NOTCH1
13 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.61 EP300 TP53
14 entrainment of circadian clock by photoperiod GO:0043153 9.58 CRTC1 TP53
15 positive regulation of protein export from nucleus GO:0046827 9.57 GAS6 TP53
16 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.56 EP300 RBL2 SOX4 TP53
17 replicative senescence GO:0090399 9.52 CDKN2A TP53
18 somatic stem cell division GO:0048103 9.49 CDKN2A NOTCH1
19 positive regulation of Notch signaling pathway GO:0045747 9.26 EP300 MAML2 MAML3 NOTCH1
20 positive regulation of transcription of Notch receptor target GO:0007221 8.92 EP300 MAML2 MAML3 NOTCH1
21 regulation of transcription, DNA-templated GO:0006355 10.09 CDKN2A CRTC1 EP300 MAML2 MAML3 NOTCH1
22 transcription, DNA-templated GO:0006351 10.02 CDKN2A CRTC1 EP300 MAML2 MAML3 NOTCH1

Sources for Schneiderian Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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