MCID: SCH002
MIFTS: 50

Schnitzler Syndrome

Categories: Bone diseases, Immune diseases, Rare diseases

Aliases & Classifications for Schnitzler Syndrome

MalaCards integrated aliases for Schnitzler Syndrome:

Name: Schnitzler Syndrome 12 52 58 54 43 15 17 71
Chronic Urticaria with Macroglobulinemia 52 58
Chronic Urticaria with Gammopathy 52 58
Chronic Urticaria with Gammapathy 52

Characteristics:

Orphanet epidemiological data:

58
schnitzler syndrome
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases


Summaries for Schnitzler Syndrome

NIH Rare Diseases : 52 Schnitzler syndrome is a rare autoinflammatory condition. Signs and symptoms of the condition vary but may include urticaria ; recurrent fevers; joint pain and inflammation; organomegaly (abnormally enlarged organs ); and/or blood abnormalities. The exact underlying cause of the condition is unknown; however, most cases occur sporadically in people with no family history of the condition. Treatment is focused on alleviating the signs and symptoms associated with the condition and may include various medications and/or phototherapy .

MalaCards based summary : Schnitzler Syndrome, also known as chronic urticaria with macroglobulinemia, is related to urticaria and autoinflammatory syndrome, and has symptoms including rash An important gene associated with Schnitzler Syndrome is IL1R1 (Interleukin 1 Receptor Type 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Rilonacept and Givinostat hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include bone, spleen and liver, and related phenotypes are splenomegaly and hepatomegaly

Disease Ontology : 12 A hypersensitivity reaction type IV disease that is characterized by chronic urticarial rash and monoclonal IgM gammopathy, has symptom rash, intermittent fever, arthralgia, and lymphadenopathy.

Wikipedia : 74 Schnitzler syndrome or Schnitzler's syndrome is a rare disease characterised by onset around middle age... more...

Related Diseases for Schnitzler Syndrome

Diseases related to Schnitzler Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
# Related Disease Score Top Affiliating Genes
1 urticaria 30.9 NLRP3 CRP CD40LG
2 autoinflammatory syndrome 30.8 NLRP3 NLRP12
3 exanthem 30.4 NLRP3 IL1RN CRP CD40LG
4 physical urticaria 30.3 NLRP3 CRP
5 amyloidosis 30.0 NLRP3 IL1RN CRP CD40LG
6 aortitis 29.7 IL1RN CRP CD40LG
7 hyper-igd syndrome 29.5 MVK IL1RN CRP
8 wells syndrome 29.4 NLRP3 IL1RAPL2 IL1R1 IL1B CRP
9 relapsing fever 29.3 MVK CRP
10 adult-onset still's disease 29.3 IL1RN IL1RAPL2 IL1R1 IL1B IL18 CRP
11 skin disease 29.0 IL18 CRP CD40LG CASP1
12 periodic fever, familial, autosomal dominant 28.2 NLRP3 NLRP12 MVK IL1RN IL1B CASP1
13 rheumatoid arthritis 28.2 IL1RN IL1RAPL2 IL1R1 IL1B IL18 CRP
14 familial mediterranean fever 27.0 PYCARD NLRP3 MVK IL1RN IL1R1 IL1B
15 cinca syndrome 26.1 PYCARD NLRP3 NLRP12 MVK IL1RN IL1RAPL2
16 muckle-wells syndrome 26.1 PYCARD NLRP3 NLRP12 MVK IL1RN IL1RAPL2
17 neisseria meningitidis infection 10.4 IL1RN IL1R1
18 bone sarcoma 10.4 IL1RN IL1R1
19 pars planitis 10.4 IL1RN IL1R1
20 meningococcemia 10.4 IL1RN IL1B
21 lymphoproliferative syndrome 10.4
22 amyloidosis aa 10.4
23 vasculitis 10.3
24 stachybotrys chartarum 10.3 IL1B IL18
25 sapho syndrome 10.3 IL1RN IL18
26 macroglobulinemia 10.3
27 autoinflammation with arthritis and dyskeratosis 10.3 IL18 CASP1
28 silo filler's disease 10.3 IL1R1 CASP1
29 inflammatory bowel disease 23 10.3 IL1RN CRP
30 anterior scleritis 10.3 IL1RAPL2 CRP
31 cold urticaria 10.3 NLRP3 IL1RAPL2 IL1R1
32 baastrup's syndrome 10.3 IL1RN CRP
33 wissler's syndrome 10.2 IL1RN CRP
34 prosthetic joint infection 10.2 IL1B CRP
35 hypopyon 10.2 IL1RN CRP
36 heart aneurysm 10.2 IL1RN CRP
37 coronary aneurysm 10.2 IL1RN CRP
38 chondromalacia 10.2 IL1RN CRP
39 cerebral artery occlusion 10.2 IL1RN IL1RAPL2 IL1B
40 constrictive pericarditis 10.2 IL1RN CRP
41 lymphoma 10.2
42 b-cell lymphoma 10.2
43 focal chorioretinitis 10.2 NLRP3 CD40LG
44 mastitis 10.2 IL1RN IL1R1 IL18
45 familial cold autoinflammatory syndrome 1 10.2 NLRP3 IL1R1 CASP1
46 pneumoconiosis 10.2 NLRP3 IL1RN IL1B
47 osteosclerotic myeloma 10.2 IL1B CD40LG
48 periostitis 10.1 IL1RN CRP
49 erysipeloid 10.1 PYCARD NLRP12
50 chondrocalcinosis 10.1 NLRP3 IL1RN CASP1

Graphical network of the top 20 diseases related to Schnitzler Syndrome:



Diseases related to Schnitzler Syndrome

Symptoms & Phenotypes for Schnitzler Syndrome

Human phenotypes related to Schnitzler Syndrome:

58 31 (show all 22)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 splenomegaly 58 31 hallmark (90%) Very frequent (99-80%) HP:0001744
2 hepatomegaly 58 31 hallmark (90%) Very frequent (99-80%) HP:0002240
3 arthritis 58 31 hallmark (90%) Very frequent (99-80%) HP:0001369
4 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
5 arthralgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002829
6 skin rash 58 31 hallmark (90%) Very frequent (99-80%) HP:0000988
7 macule 58 31 hallmark (90%) Very frequent (99-80%) HP:0012733
8 papule 58 31 hallmark (90%) Very frequent (99-80%) HP:0200034
9 urticaria 58 31 hallmark (90%) Very frequent (99-80%) HP:0001025
10 myalgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0003326
11 bone pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0002653
12 increased bone mineral density 58 31 hallmark (90%) Very frequent (99-80%) HP:0011001
13 increased circulating igm level 31 hallmark (90%) HP:0003496
14 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
15 anemia 58 31 frequent (33%) Frequent (79-30%) HP:0001903
16 leukocytosis 58 31 frequent (33%) Frequent (79-30%) HP:0001974
17 pruritus 58 31 occasional (7.5%) Occasional (29-5%) HP:0000989
18 peripheral neuropathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0009830
19 lymphoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0002665
20 vasculitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002633
21 lymphadenopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0002716
22 increased igm level 58 Very frequent (99-80%)

Symptoms:

12
  • rash

GenomeRNAi Phenotypes related to Schnitzler Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 CASP1 CD40LG IL18 IL1B NLRP3 PYCARD
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 CASP1 CD40LG IL18 IL1B NLRP3 PYCARD

MGI Mouse Phenotypes related to Schnitzler Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 CASP1 CD40LG IL18 IL1B IL1R1 IL1RN
2 homeostasis/metabolism MP:0005376 9.96 CASP1 CD40LG CRP IL18 IL1B IL1R1
3 immune system MP:0005387 9.85 CASP1 CD40LG CRP IL18 IL1B IL1R1
4 integument MP:0010771 9.5 CASP1 CD40LG IL18 IL1B IL1R1 IL1RN
5 neoplasm MP:0002006 9.02 CASP1 IL1B IL1R1 NLRP12 PYCARD

Drugs & Therapeutics for Schnitzler Syndrome

Drugs for Schnitzler Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rilonacept Approved, Investigational Phase 2 501081-76-1 104924
2 Givinostat hydrochloride Phase 2
3 Histone Deacetylase Inhibitors Phase 2
4 Antibodies, Monoclonal Phase 2
5 Immunologic Factors Phase 2
6 Antibodies Phase 2
7 Immunoglobulins Phase 2
8 Anti-Inflammatory Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effects and Side Effects of ITS2357 in Autoinflammatory Syndromes Unknown status NCT00442182 Phase 2 ITF2357
2 A Multi-center, Double-blind, Placebo-controlled Phase II Study of the Efficacy and Safety of Canakinumab in Subjects With Schnitzler Syndrome Completed NCT01390350 Phase 2 Canakinumab;Placebo
3 Efficacy and Safety of Canakinumab in Schnitzler Syndrome Completed NCT01276522 Phase 2 Canakinumab
4 Ilaris (Canakinumab) in the Schnitzler Syndrome. A Case Series. Completed NCT01245127 Phase 2 Ilaris
5 A Single-Centre, Open Label Study of the Safety and Tolerability of Rilonacept in Subjects Living in Germany With Muckle-Wells Syndrome (MWS), a Cryopyrin-Associated Periodic Syndrome (CAPS), or Schnitzler Syndrome (SchS) Completed NCT01045772 Phase 2 rilonacept
6 A Pilot, Open-Label, Phase 2, Single-Center, Repeat Dose, Proof- Of-Concept Safety, Pharmacodynamics and Efficacy Study of Orally Administered Dapansutrile Capsules in Subjects With Schnitzler's Syndrome Recruiting NCT03595371 Phase 2 dapansutrile
7 A Pilot Open-label Study to Assess the Efficacy and Safety of Tocilizumab in Patients With Active Schnitzler's Syndrome Recruiting NCT03046381 Phase 2 Tocilizumab
8 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Completed NCT00933296

Search NIH Clinical Center for Schnitzler Syndrome

Cochrane evidence based reviews: schnitzler syndrome

Genetic Tests for Schnitzler Syndrome

Anatomical Context for Schnitzler Syndrome

MalaCards organs/tissues related to Schnitzler Syndrome:

40
Bone, Spleen, Liver, Skin, B Cells, T Cells, Heart

Publications for Schnitzler Syndrome

Articles related to Schnitzler Syndrome:

(show top 50) (show all 168)
# Title Authors PMID Year
1
Schnitzler syndrome: response to anakinra in two cases and a review of the literature. 54 61
20064173 2009
2
The Schnitzler syndrome: chronic urticaria and monoclonal gammopathy--an autoinflammatory syndrome? 54 61
18371052 2008
3
Schnitzler syndrome: beyond the case reports: review and follow-up of 94 patients with an emphasis on prognosis and treatment. 54 61
17586002 2007
4
Long-term Efficacy of Canakinumab in the Treatment of Schnitzler Syndrome. 61
31940469 2020
5
Exploratory Study of MYD88 L265P, Rare NLRP3 Variants, and Clonal Hematopoiesis Prevalence in Patients With Schnitzler Syndrome. 61
31268627 2019
6
Diagnostic value of 18-F fluorodeoxyglucose PET/CT and bone scan in Schnitzler syndrome. 61
31646899 2019
7
Monoclonal Gammopathy, Arthralgias, and Recurrent Fever Syndrome: A New Autoinflammatory Syndrome? 61
30877203 2019
8
Neutrophilic urticarial dermatosis: an entity bridging monogenic and polygenic autoinflammatory disorders, and beyond. 61
31562783 2019
9
[Membranoproliferative glomerulonephritis with relapsing episodes of acute kidney injury in the Schnitzler syndrome]. 61
31251000 2019
10
Schnitzler syndrome. 61
31165908 2019
11
Cytokines and soluble receptors of the interleukin-1 family in Schnitzler syndrome. 61
30668200 2019
12
Variable Responses to Tocilizumab in Four Patients with Schnitzler Syndrome. 61
31111419 2019
13
Schnitzler syndrome associated with MYD88 L265P mutation. 61
30989098 2019
14
Association of CCL2 with systemic inflammation in Schnitzler syndrome. 61
30339714 2019
15
CCL2 serves as a downstream effector of interleukin-1β and tumour necrosis factor-α signalling in Schnitzler syndrome. 61
30933334 2019
16
[Schnitzler syndrome]. 61
30666414 2019
17
The First Case Report of Schnitzler Syndrome Presenting with Eye Pain. 61
30794479 2019
18
Neutrophilic urticarial dermatosis: A review. 61
30224079 2018
19
[Diagnosis and treatment of Schnitzler syndrome]. 61
30612413 2018
20
[Schnitzler syndrome]. 61
30167710 2018
21
Schnitzler syndrome co-occurring with idiopathic multicentric Castleman disease that responds to anti-IL-1 therapy: A case report and clue to pathophysiology. 61
30108026 2018
22
Schnitzler syndrome: A rare cause of chronic recalcitrant urticaria successfully treated with Anakinra. 61
29027204 2018
23
Schnitzler Syndrome: A Case Report and Review of Literature. 61
30065595 2018
24
Mimickers of Urticaria: Urticarial Vasculitis and Autoinflammatory Diseases. 61
29871797 2018
25
Ibrutinib for the Management of Schnitzler Syndrome: A Novel Therapy for a Rare Condition. 61
29558252 2018
26
[Schnitzler syndrome: a case report]. 61
30032576 2018
27
Schnitzler syndrome associated with hairy cell leukemia presenting with chronic urticaria and arthralgias. 61
29693079 2018
28
[Clinical overview of auto-inflammatory diseases]. 61
29501512 2018
29
Molecular genetic investigation, clinical features, and response to treatment in 21 patients with Schnitzler syndrome. 61
29284595 2018
30
The elusive pathogenesis of Schnitzler syndrome. 61
29496698 2018
31
Use of skin biomarker profiles to distinguish Schnitzler syndrome from chronic spontaneous urticaria: results of a pilot study. 61
28580686 2018
32
Schnitzler syndrome in a patient with a family history of monoclonal gammopathy. 61
29469761 2018
33
Schnitzler syndrome with IgG gammopathy and elevated IL-1β and IL-17 in skin biopsy. 61
29162318 2018
34
A Rare but Fascinating Disorder: Case Collection of Patients with Schnitzler Syndrome. 61
29707401 2018
35
Kidney involvement in the Schnitzler syndrome, a rare disease. 61
29225799 2017
36
Peripheral T-cell lymphoma mimicking Schnitzler syndrome. 61
27321901 2017
37
Schnitzler Syndrome With Response to Anakinra Monotherapy: 7 Years of Follow-up. 61
28728792 2017
38
Radiotherapy for a breast cancer patient with Schnitzler syndrome: Report of acute toxicity and early follow-up. 61
28932175 2017
39
Schnitzler syndrome, a rare autoinflammatory disease. Complete response to IL-1 blockade. 61
29291047 2017
40
Aortitis: A new feature of Schnitzler syndrome. 61
28971133 2017
41
Beyond Urticaria: Schnitzler Syndrome. 61
28552842 2017
42
Schnitzler Syndrome: a Review. 61
28718061 2017
43
Schnitzler Syndrome With Delirium and Vertigo: The Utility of Neurologic Manifestations in Diagnosis. 61
28686783 2017
44
Disorders characterized by predominant or exclusive dermal inflammation. 61
28094164 2017
45
Biologic Therapy in the Treatment of Chronic Skin Disorders. 61
28366479 2017
46
[Refractory urticaria: Schnitzler syndrome]. 61
29077281 2017
47
Efficacy and safety of canakinumab in Schnitzler syndrome: A multicenter randomized placebo-controlled study. 61
27658762 2017
48
Schnitzler syndrome: validation and applicability of diagnostic criteria in real-life patients. 61
27564982 2017
49
The Schnitzler syndrome: chronic urticaria in disguise: a single-centre report of 11 cases and a critical reappraisal of the literature. 61
27606610 2017
50
Monoclonal gammopathy of cutaneous significance: review of a relevant concept. 61
27501129 2017

Variations for Schnitzler Syndrome

Expression for Schnitzler Syndrome

Search GEO for disease gene expression data for Schnitzler Syndrome.

Pathways for Schnitzler Syndrome

Pathways related to Schnitzler Syndrome according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 PYCARD NLRP3 IL1RN IL1R1 IL1B IL18
2
Show member pathways
13.2 IL1RN IL1R1 IL1B IL18 CD40LG CASP1
3
Show member pathways
12.97 PYCARD NLRP3 NLRP12 IL1B IL18 CASP1
4
Show member pathways
12.69 PYCARD NLRP3 IL1B IL18 CASP1
5
Show member pathways
12.61 PYCARD IL1B IL18 CASP1
6
Show member pathways
12.45 IL1R1 IL1B CD40LG CASP1
7
Show member pathways
12.19 IL1RN IL1R1 IL1B CASP1
8 12.17 PYCARD NLRP3 IL1R1 IL1B IL18 CASP1
9
Show member pathways
12.09 IL1RN IL1R1 IL1B IL18
10
Show member pathways
12.08 PYCARD NLRP3 IL1B CASP1
11
Show member pathways
12.06 PYCARD NLRP3 IL1B CASP1
12 11.94 PYCARD NLRP3 IL1R1 IL1B IL18 CASP1
13
Show member pathways
11.93 IL1R1 IL1B IL18
14
Show member pathways
11.87 PYCARD NLRP3 CASP1
15
Show member pathways
11.86 IL1R1 IL1B IL18
16 11.85 PYCARD NLRP3 IL1B IL18 CASP1
17 11.81 IL1R1 IL1B CD40LG
18 11.7 PYCARD IL1B IL18 CASP1
19 11.69 PYCARD NLRP3 NLRP12 IL1B IL18 CASP1
20 11.68 IL1R1 IL1B IL18
21 11.66 PYCARD NLRP3 IL1B CASP1
22 11.62 IL1RN IL1B IL18
23 11.51 PYCARD IL1B IL18 CASP1
24 11.44 IL1B IL18 CD40LG
25 11.42 IL1RN IL1R1 IL1B IL18
26 11.03 IL1B IL18 CASP1
27 10.96 NLRP3 IL1R1 IL1B IL18
28 10.94 IL1R1 IL18
29 10.71 PYCARD NLRP3 NLRP12 IL1B IL18 CASP1
30 10.43 IL1B IL18 CASP1

GO Terms for Schnitzler Syndrome

Cellular components related to Schnitzler Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 PYCARD NLRP3 IL1RN IL1R1 IL1B IL18
2 AIM2 inflammasome complex GO:0097169 9.26 PYCARD CASP1
3 NLRP1 inflammasome complex GO:0072558 8.96 PYCARD CASP1
4 NLRP3 inflammasome complex GO:0072559 8.8 PYCARD NLRP3 CASP1

Biological processes related to Schnitzler Syndrome according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.92 IL1RN IL1R1 IL1B IL18 CD40LG
2 cellular response to lipopolysaccharide GO:0071222 9.85 PYCARD NLRP3 IL1RN IL1B CASP1
3 cytokine-mediated signaling pathway GO:0019221 9.85 IL1RN IL1RAPL2 IL1R1 IL1B IL18 CASP1
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 PYCARD NLRP3 IL1B IL18 CD40LG
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.82 IL1RN IL1B CASP1
6 negative regulation of inflammatory response GO:0050728 9.8 NLRP3 NLRP12 MVK
7 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.8 PYCARD NLRP3 NLRP12 CASP1
8 regulation of inflammatory response GO:0050727 9.78 PYCARD NLRP3 IL1R1 CASP1
9 interleukin-1-mediated signaling pathway GO:0070498 9.77 IL1RN IL1R1 IL1B
10 positive regulation of inflammatory response GO:0050729 9.77 NLRP12 IL1B IL18
11 positive regulation of JNK cascade GO:0046330 9.76 PYCARD IL1RN IL1B
12 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.75 PYCARD NLRP3 NLRP12
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.72 NLRP12 IL1B IL18
14 positive regulation of interleukin-6 production GO:0032755 9.71 PYCARD IL1RN IL1B
15 positive regulation of interferon-gamma production GO:0032729 9.71 PYCARD IL1R1 IL1B IL18
16 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.69 PYCARD NLRP3 CASP1
17 signal transduction GO:0007165 9.65 PYCARD NLRP3 NLRP12 IL1RN IL1RAPL2 IL1R1
18 positive regulation of activated T cell proliferation GO:0042104 9.64 PYCARD IL18
19 positive regulation of interleukin-4 production GO:0032753 9.64 NLRP3 CD40LG
20 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.63 NLRP12 IL1B
21 positive regulation of interleukin-1 beta production GO:0032731 9.63 PYCARD CASP1
22 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.62 PYCARD NLRP12
23 positive regulation of neuroinflammatory response GO:0150078 9.61 IL1B IL18
24 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.61 IL1B IL18
25 positive regulation of T-helper 2 cell differentiation GO:0045630 9.57 NLRP3 IL18
26 interleukin-6 production GO:0032635 9.56 IL1B IL18
27 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.5 IL1R1 IL1B IL18
28 positive regulation of interleukin-1 beta secretion GO:0050718 9.46 PYCARD NLRP3 NLRP12 CASP1
29 interleukin-1 beta production GO:0032611 9.43 PYCARD NLRP3 IL1B
30 inflammatory response GO:0006954 9.23 PYCARD NLRP3 IL1RN IL1R1 IL1B IL18

Molecular functions related to Schnitzler Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.15 PYCARD NLRP3 NLRP12 MVK IL1RN IL1RAPL2
2 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.32 PYCARD CASP1
3 interleukin-1 receptor binding GO:0005149 9.26 IL1RN IL1B
4 cytokine activity GO:0005125 9.26 IL1RN IL1B IL18 CD40LG
5 interleukin-1 receptor activity GO:0004908 9.16 IL1RAPL2 IL1R1
6 cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656 8.8 PYCARD NLRP12 CASP1

Sources for Schnitzler Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....