MCID: SCH001
MIFTS: 28

Schwannoma of Twelfth Cranial Nerve

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Schwannoma of Twelfth Cranial Nerve

MalaCards integrated aliases for Schwannoma of Twelfth Cranial Nerve:

Name: Schwannoma of Twelfth Cranial Nerve 12 15
Schwannoma of the Twelfth Cranial Nerve 71
Hypoglossal Schwannoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3197
NCIt 49 C5434
UMLS 71 C1335928

Summaries for Schwannoma of Twelfth Cranial Nerve

Disease Ontology : 12 A neurilemmoma that is located in the 12th cranial nerve.

MalaCards based summary : Schwannoma of Twelfth Cranial Nerve, also known as schwannoma of the twelfth cranial nerve, is related to neurilemmoma and plexiform schwannoma. An important gene associated with Schwannoma of Twelfth Cranial Nerve is NF2 (Neurofibromin 2). Affiliated tissues include 12th cranial nerve, tongue and thymus, and related phenotypes are Decreased cell migration and Increased cell migration

Related Diseases for Schwannoma of Twelfth Cranial Nerve

Diseases related to Schwannoma of Twelfth Cranial Nerve via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 neurilemmoma 31.3 SMARCB1 NF2 NF1
2 plexiform schwannoma 30.7 NF2 NF1
3 neurofibromatosis, type iv, of riccardi 30.3 SMARCB1 NF2 NF1
4 epithelioid neurofibroma 10.5 NF2 NF1
5 amyloid tumor 10.5 NF2 NF1
6 orbital cancer 10.5 NF2 NF1
7 polyp of corpus uteri 10.5 NF2 NF1
8 rete ovarii adenoma 10.5 NF2 NF1
9 rete ovarii neoplasm 10.5 NF2 NF1
10 cellular schwannoma 10.5 NF2 NF1
11 adult malignant schwannoma 10.4 NF2 NF1
12 optic nerve glioma 10.4 NF2 NF1
13 neurofibrosarcoma 10.4 NF2 NF1
14 lateral medullary syndrome 10.3 SLC52A1 CANX
15 obstructive hydrocephalus 10.3 NF2 NF1
16 monosomy 22 10.3 SMARCB1 NF2
17 cerebral falx meningioma 10.3 SMARCB1 NF2
18 anterior cranial fossa meningioma 10.3 SMARCB1 NF2
19 optic nerve sheath meningioma 10.3 SMARCB1 NF2
20 schwannomatosis 1 10.3 SMARCB1 NF2
21 mucinous stomach adenocarcinoma 10.3 NF2 KRT7
22 epididymal neoplasm 10.3 NF1 KRT7
23 rhabdoid meningioma 10.3 SMARCB1 NF2
24 secretory meningioma 10.2 NF2 KRT7
25 neurilemmoma of the fifth cranial nerve 10.2 TFF3 NF2 NF1
26 bladder leiomyoma 10.2 NF1 KRT7
27 trigeminal nerve neoplasm 10.2 TFF3 NF2 NF1
28 clear cell meningioma 10.2 SMARCB1 NF2
29 chordoid glioma 10.2 NF2 KRT7
30 horner's syndrome 10.2 NF1 KRT7
31 vulvar melanoma 10.2 NF1 MLANA
32 bladder benign neoplasm 10.2 NF1 KRT7
33 cerebrospinal fluid leak 10.1
34 headache 10.1
35 peripheral nerve schwannoma 10.1 SMARCB1 NF2 NF1
36 optic nerve neoplasm 10.1 SMARCB1 NF2 NF1
37 spinal canal and spinal cord meningioma 10.1 SMARCB1 NF2 NF1
38 spinal meningioma 10.1 SMARCB1 NF2 NF1
39 corpus callosum lipoma 10.1 SMARCB1 NF2 NF1
40 cerebral hemisphere lipoma 10.1 SMARCB1 NF2 NF1
41 spinal cancer 10.1 SMARCB1 NF2 NF1
42 neurilemmomatosis 10.1 SMARCB1 NF2 NF1
43 acoustic neuroma 10.1 SMARCB1 NF2 NF1
44 neuroma 10.1 SMARCB1 NF2 NF1
45 esophageal adenosquamous carcinoma 10.1 KRT7 CANX
46 malignant spindle cell melanoma 10.1 NF1 MLANA
47 peritoneum cancer 10.1 NF2 KRT7
48 small intestine leiomyoma 10.0 NF2 NF1 MLANA
49 neurofibroma 10.0 NF2 NF1 MLANA
50 cerebrovascular benign neoplasm 10.0 SMARCB1 KRT7

Graphical network of the top 20 diseases related to Schwannoma of Twelfth Cranial Nerve:



Diseases related to Schwannoma of Twelfth Cranial Nerve

Symptoms & Phenotypes for Schwannoma of Twelfth Cranial Nerve

GenomeRNAi Phenotypes related to Schwannoma of Twelfth Cranial Nerve according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.46 GJB1 MUSK NF1 NF2
2 Increased cell migration GR00055-A-3 9.26 GJB1 MUSK NF1 NF2
3 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Schwannoma of Twelfth Cranial Nerve:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.1 AAAS BLNK FPR1 GJB1 KRT7 LMNB1
2 homeostasis/metabolism MP:0005376 10.1 AAAS FPR1 GJB1 KRT7 LMNB1 MUSK
3 growth/size/body region MP:0005378 10.07 AAAS CANX GJB1 LMNB1 MUSK NF1
4 immune system MP:0005387 9.96 BLNK CANX FPR1 GJB1 NF1 NF2
5 integument MP:0010771 9.7 LMNB1 MLANA MUSK NF1 NF2 SMARCB1
6 mortality/aging MP:0010768 9.7 BLNK CANX FPR1 GJB1 LMNB1 MUSK
7 nervous system MP:0003631 9.32 AAAS CANX GJB1 LMNB1 MUSK NF1

Drugs & Therapeutics for Schwannoma of Twelfth Cranial Nerve

Search Clinical Trials , NIH Clinical Center for Schwannoma of Twelfth Cranial Nerve

Genetic Tests for Schwannoma of Twelfth Cranial Nerve

Anatomical Context for Schwannoma of Twelfth Cranial Nerve

The Foundational Model of Anatomy Ontology organs/tissues related to Schwannoma of Twelfth Cranial Nerve:

19
12th Cranial Nerve

MalaCards organs/tissues related to Schwannoma of Twelfth Cranial Nerve:

40
Tongue, Thymus, Spinal Cord, Small Intestine, Kidney, Uterus

Publications for Schwannoma of Twelfth Cranial Nerve

Articles related to Schwannoma of Twelfth Cranial Nerve:

(show all 44)
# Title Authors PMID Year
1
[Hypoglossal schwannoma: case report and literature review]. 61
31825375 2019
2
Muscular-stage Dissection during Far Lateral Approach and Its Transcondylar Extension. 61
30210990 2018
3
Single-stage total resection of giant dumbbell-shaped hypoglossal schwannoma: a case report. 61
29285680 2018
4
Hypoglossal Schwannoma of Neck: Case Report and Review of Literature. 61
29175571 2018
5
Hypofractionated stereotactic radiotherapy for dumbbell-shaped hypoglossal schwannomas: Two cases of long-term follow-up and a review of the literature. 61
27446582 2016
6
Giant recurrent dumbbell-shaped hypoglossal schwannoma in an elderly male: A case report. 61
26870204 2016
7
Hypoglossal schwannoma of parapharyngeal space: an unusual case report. 61
25838673 2015
8
Spatial Relationship between Hypoglossal Schwannoma and the Vertebral Artery Using the Far-Lateral Approach. 61
26345663 2015
9
Diffuse cerebral vasospasm following resection of a hypoglossal schwannoma in a child. 61
24350734 2014
10
Management of hypoglossal schwannomas: single institutional experience of 14 cases. 61
25072009 2014
11
Spontaneous regression of a cystic hypoglossal schwannoma causing unilateral tongue atrophy. 61
23855391 2014
12
Acute brainstem compression by intratumoral hemorrhages in an intracranial hypoglossal schwannoma. 61
23541888 2013
13
Hypoglossal schwannoma presenting as hemi-atrophy of the tongue. 61
23860167 2013
14
Plexiform hypoglossal schwannoma of the tongue and the submandibular region. 61
22976661 2012
15
Isolated hypoglossal schwannoma in a 9-year-old child. 61
22725844 2012
16
Surgical treatment of dumbbell-shaped hypoglossal schwannoma via a pure endoscopic transoral approach. 61
22009014 2012
17
Hypoglossal schwannoma masquerading as a carotid body tumor. 61
23213586 2012
18
Hypoglossal nerve schwannoma with intratumoral hemorrhage. 61
21837502 2012
19
Endoscopic transoral approach for extracranial hypoglossal schwannoma. 61
21876364 2011
20
Intraoperative monitoring during surgery for hypoglossal schwannoma. 61
20488709 2010
21
Large cystic hypoglossal schwannoma with fluid-fluid level: a case report. 61
21318038 2010
22
Hypoglossal schwannoma presenting only with headache. 61
20098193 2010
23
[Surgical strategy for hypoglossal schwannoma]. 61
20085098 2010
24
Hypoglossal schwannoma-successful reinnervation and functional recovery of the tongue following tumour removal and nerve grafting. 61
19290472 2009
25
Isolated unilateral hypoglossal nerve palsy secondary to an atlantooccipital joint juxtafacet synovial cyst. 61
19320583 2009
26
Extradural dumbbell schwannoma of the hypoglossal nerve: a case report with review of the literature. 61
18423539 2008
27
Intradural microsurgery and extradural gamma knife surgery for hypoglossal schwannoma: case report and review of the literature. 61
18210363 2007
28
Hypoglossal schwannoma presenting as hemi-atrophy of the tongue. 61
17486732 2007
29
[MRI performance and diagnosis of schwannomas from cranial nerves in posterior cranial fossae]. 61
16965666 2006
30
Usefulness of transcervical approach for surgical treatment of hypoglossal schwannoma with paraspinal extension: case report. 61
16531208 2006
31
Dumbbell-shaped hypoglossal schwannoma in an elderly woman: a clinical dilemma. 61
15936371 2005
32
Navigated dorsolateral suboccipital transcondylar (NADOSTA) approach for treatment of hypoglossal schwannoma. Case report and review of the literature. 61
15823681 2005
33
Bilateral hypoglossal schwannoma: a radiologic diagnosis. 61
16010098 2004
34
Extracranial hypoglossal schwannoma. 61
12821768 2003
35
Dumbbell-shaped hypoglossal schwannoma. A case report. 61
12670602 2003
36
Stereotactic radiosurgery: the preferred management for patients with nonvestibular schwannomas? 61
11958895 2002
37
Health-related quality of life in patients with skull base tumours. 61
11926460 2002
38
Hypoglossal schwannoma in the submandibular space. 61
11860659 2002
39
Hypoglossal schwannoma: an uncommon cause of twelfth-nerve palsy. 61
10846888 2000
40
Hemorrhagic necrotic schwannoma presenting as purulent meningitis. 61
9604141 1998
41
Surgical management of transcranial hypoglossal schwannomas. 61
8588644 1995
42
Hypoglossal schwannoma. 61
7771724 1995
43
Hemiatrophy of the tongue due to hypoglossal schwannoma shown by MRI. 61
8041451 1994
44
Intracranial hypoglossal schwannoma as an unusual cause of facial nerve palsy. Case report. 61
7057241 1982

Variations for Schwannoma of Twelfth Cranial Nerve

Expression for Schwannoma of Twelfth Cranial Nerve

Search GEO for disease gene expression data for Schwannoma of Twelfth Cranial Nerve.

Pathways for Schwannoma of Twelfth Cranial Nerve

GO Terms for Schwannoma of Twelfth Cranial Nerve

Biological processes related to Schwannoma of Twelfth Cranial Nerve according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of MAPK cascade GO:0043409 9.16 NF2 NF1
2 artery morphogenesis GO:0048844 8.96 TBX1 NF1
3 negative regulation of cell-matrix adhesion GO:0001953 8.62 NF2 NF1

Sources for Schwannoma of Twelfth Cranial Nerve

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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