Aliases & Classifications for Sciatic Neuropathy

MalaCards integrated aliases for Sciatic Neuropathy:

Name: Sciatic Neuropathy 12 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:11446
MeSH 43 D020426
SNOMED-CT 67 52585001
UMLS 71 C0149940

Summaries for Sciatic Neuropathy

MalaCards based summary : Sciatic Neuropathy is related to radiculopathy and plexopathy, and has symptoms including sciatica An important gene associated with Sciatic Neuropathy is TMEM119 (Transmembrane Protein 119). The drugs Lidocaine and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and kidney.

Related Diseases for Sciatic Neuropathy

Diseases related to Sciatic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 radiculopathy 30.3 RPL34 PMP22
2 plexopathy 30.0 RPL34 PMP22
3 neuropathy, hereditary, with liability to pressure palsies 29.4 SH3TC2 PMP22 PES1
4 mononeuropathy 28.7 TRPV1 SH3TC2 RPL34 PMP22 PES1
5 peripheral nervous system disease 28.6 TRPV1 SH3TC2 RPL34 PMP22 PES1
6 neuropathy 10.9
7 foot drop 10.3
8 paresthesia 10.2
9 tibial nerve palsy 10.2 RPL34 PMP22
10 cauda equina syndrome 10.1 RPL34 PMP22
11 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.1
12 compartment syndrome 10.1
13 vasculitis 10.1
14 scheuermann disease 10.1 RPL34 PES1
15 tethered spinal cord syndrome 10.1 RPL34 PES1
16 lumbosacral lipoma 10.1 RPL34 PES1
17 charcot-marie-tooth disease, type 4b3 10.0 SH3TC2 PMP22
18 charcot-marie-tooth disease, demyelinating, type 1c 10.0 SH3TC2 PMP22
19 ocular motor apraxia 10.0
20 thrombosis 10.0
21 arteriovenous malformation 10.0
22 spinal stenosis 10.0
23 diabetes mellitus 10.0
24 peroneal nerve paralysis 10.0 PMP22 PES1
25 polyradiculoneuropathy 10.0 RPL34 PMP22
26 asymmetric motor neuropathy 10.0 PMP22 PES1
27 charcot-marie-tooth disease, demyelinating, type 4f 10.0 SH3TC2 PES1
28 autosomal dominant distal hereditary motor neuronopathy 9.9 SH3TC2 PES1
29 aortic aneurysm, familial abdominal, 1 9.9
30 klippel-trenaunay-weber syndrome 9.9
31 lipomatosis, multiple 9.9
32 thrombophilia due to thrombin defect 9.9
33 osteogenic sarcoma 9.9
34 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.9
35 diffuse large b-cell lymphoma 9.9
36 pleomorphic lipoma 9.9
37 gestational diabetes 9.9
38 enterocele 9.9
39 quadriplegia 9.9
40 ehlers-danlos syndrome 9.9
41 frozen shoulder 9.9
42 neuritis 9.9
43 acromegaly 9.9
44 hemangioma 9.9
45 myoma 9.9
46 capillary hemangioma 9.9
47 endometriosis 9.9
48 bursitis 9.9
49 neurilemmoma 9.9
50 myelitis 9.9

Graphical network of the top 20 diseases related to Sciatic Neuropathy:



Diseases related to Sciatic Neuropathy

Symptoms & Phenotypes for Sciatic Neuropathy

UMLS symptoms related to Sciatic Neuropathy:


sciatica

Drugs & Therapeutics for Sciatic Neuropathy

Drugs for Sciatic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
3
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
4
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
5
Betamethasone Approved, Vet_approved Phase 2 378-44-9 9782
6 Respiratory System Agents Phase 2
7 Anesthetics Phase 2
8 Antineoplastic Agents, Hormonal Phase 2
9 Hormones Phase 2
10 Hormone Antagonists Phase 2
11 Pharmaceutical Solutions Phase 2
12
protease inhibitors Phase 2
13 Antiemetics Phase 2
14 HIV Protease Inhibitors Phase 2
15 Anesthetics, Local Phase 2
16 Anti-Asthmatic Agents Phase 2
17 glucocorticoids Phase 2
18 Gastrointestinal Agents Phase 2
19 Betamethasone sodium phosphate Phase 2
20 Betamethasone benzoate Phase 2
21 BB 1101 Phase 2
22 Betamethasone-17,21-dipropionate Phase 2
23 Betamethasone Valerate Phase 2 2152-44-5
24 Anti-Inflammatory Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain: Evaluate Route Versus Pharmacology of Intervention, and Feasibility in Public Hospital and Community Practice Settings. Unknown status NCT03240783 Phase 2 Betamethasone OR Dexamethasone Injectable;Normal Saline Flush, 0.9% Injectable Solution;Dexamethasone Oral Tablet
2 Effectiveness of Physical Therapy as an Adjunct to a Selective Nerve Root Block in the Treatment of Lumbar Radicular Pain From Disk Herniation Completed NCT00934284 Phase 2
3 Neuromuscular Ultrasound for Focal Neuropathies Completed NCT01394822
4 Prospective, Multi-center, Cohort Study of the Cost Effectiveness of Osteopathic Manipulative Treatment for Chronic Low Back Pain Completed NCT03532230

Search NIH Clinical Center for Sciatic Neuropathy

Cochrane evidence based reviews: sciatic neuropathy

Genetic Tests for Sciatic Neuropathy

Anatomical Context for Sciatic Neuropathy

MalaCards organs/tissues related to Sciatic Neuropathy:

40
Brain, Spinal Cord, Kidney, Breast, B Cells, Thalamus

Publications for Sciatic Neuropathy

Articles related to Sciatic Neuropathy:

(show top 50) (show all 185)
# Title Authors PMID Year
1
Radiofrequency ablation vs microwave ablation for osteoid osteomas: long-term results. 61
32564104 2020
2
Circumferential Adipose Lesion of the Sciatic Nerve. 61
32407922 2020
3
Tibialis posterior (TP) tendon transfer for foot drop: A single center experience. 61
32405209 2020
4
Sciatic neuropathy after normal vaginal delivery: A case report. 61
31822439 2020
5
Sciatic neuropathy in an acromegalic cat without concurrent diabetes mellitus. 61
32128232 2020
6
A case of solitary rectal diverticulum presenting with a large retrorectal abscess. 61
31890199 2020
7
Intraneural Ganglion Cyst of the Sciatic Nerve Treated Using Arthroscopic Hip Surgery: A Case Report. 61
30690884 2019
8
Use of fluoroscopic-guided transsacral block for the treatment of iatrogenic post-injection sciatic neuropathy: Report of three cases. 61
31893279 2019
9
Isolated injury to the tibial division of sciatic nerve after self-massage of the gluteal muscle with massage ball: A case report. 61
31083184 2019
10
Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure. 61
30961664 2019
11
Clinical and Electrodiagnostic Features Of Nontraumatic Sciatic Neuropathy. 61
30414322 2019
12
Stimulation Contractility Gradient of a Neuromuscular Choristoma Within the Sciatic Nerve: 2-Dimensional Operative Video. 61
29800277 2019
13
MRI of Foot Drop: How We Do It. 61
30152741 2018
14
Sciatic neuropathy caused by a pressure ulcer: A case report. 61
30200159 2018
15
Bilateral sciatic neuropathy with severe rhabdomyolysis following venlafaxine overdose: A case report. 61
30212953 2018
16
A Central Nervous System Tumor Mimicking a Lumbar Spine Pathology Causing Acute Foot Drop: A Case Report. 61
30740383 2018
17
Post-operative extra-spinal etiologies of sciatic nerve impingement. 61
29423723 2018
18
Utility of Magnetic Resonance Imaging for Predicting Severity of Sciatic Nerve Injury. 61
29659424 2018
19
Sciatic neuropathy and rhabdomyolysis after carbon monoxide intoxication: A case report. 61
29879074 2018
20
Sciatic neurosteatosis: Relationship with age, gender, obesity and height. 61
29063256 2018
21
Bilateral Sciatic Neuropathy following Gluteal Augmentation With Autologous Fat Grafting. 61
29707455 2018
22
Gluteal compartment syndrome with neurologic impairment: Report of 2 cases and review of the literature. 61
28224633 2018
23
Segmentation of Peripheral Nerves From Magnetic Resonance Neurography: A Fully-Automatic, Deep Learning-Based Approach. 61
30283397 2018
24
Clinical and Genetic Analysis of an Asian Indian Family with Charcot-Marie-Tooth Disease Type 4C. 61
29515423 2018
25
Prenatal alcohol exposure is a risk factor for adult neuropathic pain via aberrant neuroimmune function. 61
29258553 2017
26
Sciatic neuropathy due to popliteal fossa nerve block. 61
28214338 2017
27
Management of refractory sciatic neuropathic pain using ultrasound-guided pulsed radiofrequency. 61
28946529 2017
28
Synovial cyst of the knee: A rare case of acute sciatic neuropathy. 61
27659236 2017
29
Sciatic neuropathy: findings on magnetic resonance neurography. 61
28670031 2017
30
Observational multicentric study on chronic sciatic pain: clinical data from 44 Italian centers. 61
28429339 2017
31
Preventing Sciatic Nerve Injury due to Intramuscular Injection: Ten-Year Single-Center Experience and Literature Review. 61
27593812 2017
32
Bilateral Sciatic Neuropathy after an Autologous Breast Reconstruction in a Massive Weight Loss Patient. 61
28203505 2017
33
Chronic Sciatic Neuropathy in Rat Reduces Voluntary Wheel-Running Activity With Concurrent Chronic Mechanical Allodynia. 61
27782944 2017
34
Isolated sciatic neuropathy as an initial manifestation of a high grade B-cell lymphoma: A case report and literature review. 61
27540756 2016
35
Is diffusion tensor imaging useful in the assessment of the sciatic nerve and its pathologies? Our clinical experience. 61
27459247 2016
36
Early diagnosis of Varicella-zoster virus sciatic neuropathy by MRI neurography. 61
27625277 2016
37
Sequential early and delayed painful sciatic neuropathy following revision total hip arthroplasty. 61
26990207 2016
38
Irreversible electroporation-induced sciatic neuropathy observed by intraoperative neuromonitoring. 61
27417051 2016
39
Postpartum sciatic neuropathy: Segmental fractional anisotropy analysis to disclose neurapraxia. 61
27572428 2016
40
Tissue-engineered conduit promotes sciatic nerve regeneration following radiation-induced injury as monitored by magnetic resonance imaging. 61
26686023 2016
41
Nerve Wrapping of the Sciatic Nerve With Acellular Dermal Matrix in Chronic Complete Proximal Hamstring Ruptures and Ischial Apophyseal Avulsion Fractures. 61
27081655 2016
42
Sciatic Neuropathy Caused by Focal Venous Engorgement Associated With Deep Vein Thrombosis: A Case Report. 61
26079864 2016
43
Sciatic neuropathy developed after injection during curettage. 61
27225613 2016
44
Preventive Effects of the Chinese Herbal Medicine Prescription Tangkuei Decoction for Frigid Extremities on Sciatic Neuropathy in Streptozotocin-Induced Diabetic Rats. 61
27057201 2016
45
Leg Weakness Caused by Bilateral Piriformis Syndrome: A Case Report. 61
26798622 2015
46
Bilateral sciatic neuropathy misdiagnosed as critical illness neuropathy: a case report. 61
25990100 2015
47
The origin variability of the iliolumbar artery and iatrogenic sciatica. 61
25269394 2015
48
Effect of styrene maleic acid WIN55,212-2 micelles on neuropathic pain in a rat model. 61
25541465 2015
49
Feasibility of 18F-FDG PET as a noninvasive diagnostic tool of muscle denervation: a preliminary study. 61
25104824 2014
50
Hereditary neuropathy with liability to pressure palsies presenting with sciatic neuropathy. 61
25326571 2014

Variations for Sciatic Neuropathy

Expression for Sciatic Neuropathy

Search GEO for disease gene expression data for Sciatic Neuropathy.

Pathways for Sciatic Neuropathy

GO Terms for Sciatic Neuropathy

Biological processes related to Sciatic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to ATP GO:0071318 8.62 TRPV1 CIB2

Sources for Sciatic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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