Aliases & Classifications for Sciatic Neuropathy

MalaCards integrated aliases for Sciatic Neuropathy:

Name: Sciatic Neuropathy 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11446
MeSH 44 D020426
SNOMED-CT 68 52585001
UMLS 73 C0149940

Summaries for Sciatic Neuropathy

MalaCards based summary : Sciatic Neuropathy is related to plexopathy and neuropathy, and has symptoms including sciatica An important gene associated with Sciatic Neuropathy is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are PAK Pathway and 4-1BB Pathway. The drugs Morphine and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include brain, b cells and thalamus, and related phenotypes are cardiovascular system and integument

Related Diseases for Sciatic Neuropathy

Diseases related to Sciatic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 plexopathy 29.9 NGF NOTCH1
2 neuropathy 10.8
3 paroxysmal extreme pain disorder 10.2 SCN10A TRPV1
4 trigeminal neuralgia 10.2 SCN10A TRPV1
5 cough variant asthma 10.2 NGF TRPV1
6 mononeuropathy 10.2 MYOM2 TRPV1
7 burning mouth syndrome 10.2 NGF TRPV1
8 neurogenic arthropathy 10.2 MYOM2 NGF
9 mononeuritis of lower limb 10.2 SCN10A TRPV1 USP6
10 substernal goiter 10.1 KANTR NOTCH1
11 subclavian steal syndrome 10.1 KANTR NOTCH1
12 chronic gonococcal salpingitis 10.1 TNFRSF1A TNFRSF1B
13 pericoronitis 10.1 TNFRSF1A TNFRSF1B
14 petroclival meningioma 10.1 KANTR NOTCH1
15 brachial plexus neuritis 10.1 KANTR NOTCH1
16 paine syndrome 10.1 NGF SCN10A TRPV1
17 neuroma 10.1 NGF SCN10A TRPV1
18 periodic fever, familial, autosomal dominant 10.1 TNFRSF1A TNFRSF1B
19 optic disk drusen 10.1 KANTR NOTCH1
20 short-rib thoracic dysplasia 5 with or without polydactyly 10.1 TNFRSF1A TNFRSF1B
21 acute salpingitis 10.1 TNFRSF1A TNFRSF1B
22 cardiovascular organ benign neoplasm 10.0 KANTR TRPV1
23 post-transplant lymphoproliferative disease 10.0 TNFRSF1A TNFRSF1B
24 cochlear disease 10.0 KANTR TNFRSF1B
25 lesion of sciatic nerve 10.0 NGF SCN10A TRPV1 USP6
26 nervous system disease 10.0 KANTR NGF TRPV1
27 benign perivascular tumor 10.0 KANTR TRPV1
28 thrombosis 10.0
29 compartment syndrome 10.0
30 alveolar periostitis 10.0 KANTR TNFRSF9
31 subdural empyema 10.0 KANTR RPL34
32 dystonia 1, torsion, autosomal dominant 10.0 KANTR NOTCH1
33 chronic salpingitis 9.9 KANTR TNFRSF1A TNFRSF1B
34 peripheral nervous system disease 9.9 KANTR MYOM2 NGF TRPV1
35 ecthyma 9.9 KANTR MYOM2
36 aortic aneurysm, familial abdominal, 1 9.9
37 neuropathy, hereditary, with liability to pressure palsies 9.9
38 temporal arteritis 9.9
39 thrombophilia due to thrombin defect 9.9
40 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 9.9
41 arthritis 9.9
42 b-cell lymphomas 9.9
43 brain injury 9.9
44 breast reconstruction 9.9
45 diabetes mellitus 9.9
46 traumatic brain injury 9.9
47 lymphoma 9.9
48 ehlers-danlos syndrome 9.9
49 bursitis 9.9
50 aortic aneurysm 9.9

Graphical network of the top 20 diseases related to Sciatic Neuropathy:



Diseases related to Sciatic Neuropathy

Symptoms & Phenotypes for Sciatic Neuropathy

UMLS symptoms related to Sciatic Neuropathy:


sciatica

MGI Mouse Phenotypes related to Sciatic Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 NGF NOTCH1 PDGFB SCN10A TJP1 TNFRSF1A
2 integument MP:0010771 9.86 NGF NOTCH1 PDGFB SCN10A TNFRSF1A TNFRSF1B
3 no phenotypic analysis MP:0003012 9.63 NGF PDGFB SCN10A TNFRSF1A TNFRSF9 TRPV1
4 renal/urinary system MP:0005367 9.5 NOTCH1 PDGFB TJP1 TNFRSF1A TNFRSF1B TNFRSF9
5 vision/eye MP:0005391 9.1 NGF NOTCH1 PDGFB TNFRSF1A TNFRSF1B TNFRSF9

Drugs & Therapeutics for Sciatic Neuropathy

Drugs for Sciatic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 128)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Ibuprofen Approved Phase 4 15687-27-1 3672
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 83-43-2 6741
5
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
6
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 50-24-8 5755
7
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 302-25-0
8
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Not Applicable,Early Phase 1 2921-57-5
9
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
10
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Not Applicable,Early Phase 1 2920-86-7
11 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Analgesics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
13 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
14 Narcotics Phase 4,Phase 3,Phase 2,Not Applicable
15 Analgesics, Opioid Phase 4,Phase 3,Phase 2,Not Applicable
16 Antipyretics Phase 4
17 Analgesics, Non-Narcotic Phase 4,Phase 1,Phase 2,Not Applicable
18 Cyclooxygenase Inhibitors Phase 4,Not Applicable
19 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 1,Phase 2,Not Applicable
20 Antirheumatic Agents Phase 4,Phase 2,Phase 1,Not Applicable
21 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
22 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
25 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Gastrointestinal Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
28 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
29 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Methylprednisolone acetate Phase 4,Phase 3,Not Applicable,Early Phase 1
31 Prednisolone acetate Phase 4,Phase 3,Not Applicable,Early Phase 1
32 Neuroprotective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
33 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
34
Meperidine Approved Phase 3 57-42-1 4058
35
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
36
Oxycodone Approved, Illicit, Investigational Phase 3 76-42-6 5284603
37
Lidocaine Approved, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
38 Cortivazol Investigational Phase 3 1110-40-3
39 Adjuvants, Anesthesia Phase 3
40 Anesthetics Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
41 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
42 Neurotransmitter Agents Phase 3,Phase 2,Not Applicable
43 Adrenergic alpha-Antagonists Phase 3
44 Adrenergic Antagonists Phase 3
45 Adrenergic Agents Phase 3,Phase 2
46 Diuretics, Potassium Sparing Phase 3,Phase 1,Not Applicable
47 Anesthetics, Local Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Anti-Arrhythmia Agents Phase 3,Phase 1,Not Applicable
49 Sodium Channel Blockers Phase 3,Phase 1,Not Applicable
50
Nortriptyline Approved Phase 2,Not Applicable 72-69-5 4543

Interventional clinical trials:

(show top 50) (show all 75)
# Name Status NCT ID Phase Drugs
1 Ultrasound-guided Caudal or Interlaminar Corticosteroid Epidural Injection for Sciatica Unknown status NCT02897336 Phase 4
2 IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia Unknown status NCT02504996 Phase 4 Paracetamol;morphine;Placebo
3 Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Department Unknown status NCT02777320 Phase 4 paracetamol;Ibuprofen
4 Safety and Efficacy of Nonsteroidal Antiinflammatory (NSAI)Drug and Glucocorticoids in Acute Sciatica Completed NCT01816334 Phase 4 methylprednisolone;Ketoprofen;Sodium Chloride
5 Herniectomy Versus Herniectomy With a Spinal Stabilization System for the Treatment of Complex Disc Disease Completed NCT00749996 Phase 4
6 NSAIDs in Sciatica NSAIDS IN SCIATICA Recruiting NCT03347929 Phase 4 Naproxen 500 Mg;Placebo
7 Comparison of a Cortivazol (ALTIM®) Infiltration of Posterior Epidural Space at L3-L4 Stage Versus an Epidural Infiltration of Cortivazol (ALTIM®) on Contact With Disco Radicular Conflict in Discal Sciatica Unknown status NCT02151045 Phase 3
8 Neuraxial Pethidine After Lumbar Surgery Trial Unknown status NCT00163553 Phase 3 Pethidine;Placebo
9 Physiotherapy for Sciatica; Is Earlier Better? Completed NCT02618278 Phase 3
10 The Value of Traction in Treatment of Lumbar Radiculopathy Completed NCT00942227 Phase 3
11 The Efficacy of Oral Steroids in the Treatment of Acute Sciatica Completed NCT00317447 Phase 3 Oral Prednisone
12 Lumbar Spinal Fibrosis and TNF Alpha Inhibition Completed NCT00385086 Phase 3 TNF blocker;Placebo
13 A Study to Evaluate 90-Day Safety of Tapentadol(CG5503) Immediate Release (IR) or Oxycodone Immediate Release in Patients With Chronic Pain Completed NCT00364546 Phase 3 CG 5503;tapentadol
14 Efficacy of corticoïd Infiltration Via Sacro-coccygien Hiatus in Discal Sciatica Terminated NCT01482897 Phase 3 Prednisolone acetate;sham procedure;comparator : physiological solution
15 Study of REN-1654 in Patients With Sciatica Pain Unknown status NCT00107055 Phase 2 REN-1654
16 Effectiveness Study of Physical Therapy as an Adjunct to a Lumbar Therapeutic Selective Nerve Root Block Completed NCT00934284 Phase 2
17 Study to Evaluate the Safety and Efficacy of Placulumab (CEP-37247) Administered by the Transforaminal Epidural Route for the Treatment of Patients With Lumbosacral Radicular Pain Associated With Disk Herniation Completed NCT01240876 Phase 1, Phase 2 CEP-37247;Placebo
18 A Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of MDT-15 in Subjects With Lumbosacral Radiculopathy Completed NCT01917825 Phase 2 MDT-15
19 BG00010 (Neublastin) Phase 2 Multiple Dose Adaptive Design in Participants With Painful Lumbar Radiculopathy Completed NCT01873404 Phase 2 BG00010;Placebo
20 A Study to Evaluate the Safety and Efficacy of Subcutaneously Administered REGN475(SAR164877) in Patients With Sciatic Pain Completed NCT00991172 Phase 2 REGN475;REGN475;Placebo Injection
21 Effectiveness of Oral Prednisone in Improving Physical Functioning and Decreasing Pain in People With Sciatica Completed NCT00668434 Phase 2 Prednisone;Placebo
22 Adalimumab in Severe and Acute Sciatica Completed NCT00470509 Phase 2 adalimumab (2 subcutaneous 40 mg injections on day 0 and 7)
23 Manipulation or Microdiscectomy For Sciatica? A Prospective Randomized Controlled Trial. Completed NCT00415220 Phase 2
24 Efficacy of Epidural Etanercept in the Treatment of Sciatica Completed NCT00364572 Phase 1, Phase 2 epidural injection of etanercept;placebo (control procedure)
25 Topiramate in the Treatment of Sciatica Completed NCT00011804 Phase 2 Topiramate
26 Magnets in the Treatment of Sciatica Completed NCT00044109 Phase 2
27 Effect of Antidepressants on Back Pain Completed NCT00018200 Phase 2 Desipramine;Fluoxetine;Benztropine
28 Pain Treatment for Sciatica Completed NCT00009672 Phase 2 Nortriptyline;Morphine
29 A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain Recruiting NCT03240783 Phase 2 Betamethasone OR Dexamethasone Injectable;Normal Saline Flush, 0.9% Injectable Solution;Dexamethasone Oral Tablet
30 Energy Specific Far Infrared Radiation Treatment for Sciatica Unknown status NCT00573807 Phase 1
31 Clinical Trial to Evaluate the Safety and Analgesic Efficacy of VVZ-149 in Lumbar Radiculopathy (Sciatica) Completed NCT02644421 Phase 1 VVZ-149;Lidocaine;Placebo
32 Study of the Safety, Tolerability, Pharmacokinetics and Safety of BG00010 (Neublastin) in Subjects With Sciatica. Completed NCT01405833 Phase 1 BG00010 (Neublastin);Placebo
33 Evaluate the Safety, Tolerability and Pharmacokinetics of BG00010 (Neublastin) Administered to Sciatica Participants Completed NCT00961766 Phase 1 BG00010 (Neublastin);Placebo
34 Mechanical Diagnosis and Treatment and/or Steroid Injections for Lumbar Radiculopathy Not yet recruiting NCT02951377 Phase 1 Transforaminal epidural steroid injection (20mg dexamethasone 0.5cc lidocaine 2%)
35 Efficacy of Acupuncture for Discogenic Sciatica Unknown status NCT02770963 Not Applicable
36 "The Lived Experience of Investigations for Sciatica" Unknown status NCT02512081
37 Intradiscal Discogel® in Resistant Sciatica Unknown status NCT02313350 Not Applicable
38 Electroacupuncture for Sciatica Due to Intervertebral Disc Displacement Unknown status NCT02087462 Not Applicable Voltaren;Vitamin B1
39 Pain Relief by Platelet-rich Plasma (PRP) Treatment Unknown status NCT01749839
40 Chiropractic Spinal Manipulative Therapy for Acute Sciatica Secondary to Lumbar Disc Herniation Unknown status NCT01552486 Not Applicable
41 Efficacy of Intravenous Dexamethasone for Acute Disc Herniation-Induced Sciatica Unknown status NCT00516009 Not Applicable DEXAMETHASONE
42 Neuromuscular Ultrasound for Focal Neuropathies Completed NCT01394822
43 The Effectiveness of Neurodynamic Techniques in Patients With Nerve-Related Leg Pain Completed NCT01954199 Not Applicable
44 Effectiveness of a Novel Neural Tissue Management to Improve Short-term Pain and Disability in Patients With Sciatica Completed NCT03663842 Not Applicable
45 Outcome of Surgery for Sciatica - a Comparison of Data From Three National Quality Registries Completed NCT02889484
46 Long-Term Course of Korean Medicine Treatment for Lumbar Disc Herniation Completed NCT03426215
47 Effects of Shinbaro Pharmacopuncture in Sciatic Pain Patients With Lumbar Disc Herniation Completed NCT02384928 Not Applicable Conventional medicine
48 Alternative and Integrative Therapy for Lumbar Disk Herniation Completed NCT01989403
49 Long-term Outcomes of Surgical and Nonsurgical Management of Sciatica Secondary to a Lumbar Disc Herniation or Spinal Stenosis Completed NCT02836730
50 [18F]FTC-146 PET/MRI in Healthy Volunteers and in CRPS and Sciatica Completed NCT02753101 Early Phase 1 [18F]-FTC-146

Search NIH Clinical Center for Sciatic Neuropathy

Cochrane evidence based reviews: sciatic neuropathy

Genetic Tests for Sciatic Neuropathy

Anatomical Context for Sciatic Neuropathy

MalaCards organs/tissues related to Sciatic Neuropathy:

41
Brain, B Cells, Thalamus

Publications for Sciatic Neuropathy

Articles related to Sciatic Neuropathy:

(show top 50) (show all 96)
# Title Authors Year
1
Sciatic neuropathy and rhabdomyolysis after carbon monoxide intoxication: A case report. ( 29879074 )
2018
2
Bilateral Sciatic Neuropathy following Gluteal Augmentation With Autologous Fat Grafting. ( 29707455 )
2018
3
Clinical and electrodiagnostic features of non-traumatic sciatic neuropathy. ( 30414322 )
2018
4
Sciatic neuropathy caused by a pressure ulcer: A case report. ( 30200159 )
2018
5
Bilateral sciatic neuropathy with severe rhabdomyolysis following venlafaxine overdose: A case report. ( 30212953 )
2018
6
Sciatic neuropathy: findings on magnetic resonance neurography. ( 28670031 )
2017
7
Sciatic neuropathy due to popliteal fossa nerve block. ( 28214338 )
2017
8
Chronic Sciatic Neuropathy in Rat Reduces Voluntary Wheel-Running Activity With Concurrent Chronic Mechanical Allodynia. ( 27782944 )
2017
9
Bilateral Sciatic Neuropathy after an Autologous Breast Reconstruction in a Massive Weight Loss Patient. ( 28203505 )
2017
10
Isolated sciatic neuropathy as an initial manifestation of a high grade B-cell lymphoma: A case report and literature review. ( 27540756 )
2016
11
Preventive Effects of the Chinese Herbal Medicine Prescription Tangkuei Decoction for Frigid Extremities on Sciatic Neuropathy in Streptozotocin-Induced Diabetic Rats. ( 27057201 )
2016
12
Synovial cyst of the knee: A rare case of acute sciatic neuropathy. ( 27659236 )
2016
13
Sequential Early and Delayed Painful Sciatic Neuropathy Following Revision Total Hip Arthroplasty. ( 26990207 )
2016
14
Sciatic neuropathy developed after injection during curettage. ( 27225613 )
2016
15
Irreversible electroporation-induced sciatic neuropathy observed by intraoperative neuromonitoring. ( 27417051 )
2016
16
Postpartum sciatic neuropathy: Segmental fractional anisotropy analysis to disclose neurapraxia. ( 27572428 )
2016
17
Early diagnosis of Varicella-zoster virus sciatic neuropathy by MRI neurography. ( 27625277 )
2016
18
Bilateral sciatic neuropathy misdiagnosed as critical illness neuropathy: a case report. ( 25990100 )
2015
19
Sciatic Neuropathy Caused by Focal Venous Engorgement Associated With Deep Vein Thrombosis: A Case Report. ( 26079864 )
2015
20
Right calf claudication revealing leriche syndrome presenting as right sciatic neuropathy. ( 24639938 )
2014
21
Hereditary neuropathy with liability to pressure palsies presenting with sciatic neuropathy. ( 25326571 )
2014
22
Severe isolated sciatic neuropathy due to a modified lotus position. ( 24579070 )
2014
23
Post-injection sciatic neuropathy in a cynomolgus macaque (Macaca fascicularis). ( 24236754 )
2014
24
Gluteal Compartment Syndrome Complicated with Bilateral Sciatic Neuropathy. ( 26077186 )
2014
25
Bilateral sciatic neuropathy due to fibrous bands in a patient with severe traumatic brain injury. ( 24731584 )
2014
26
Teaching NeuroImages: sciatic neuropathy after heroin abuse. ( 23960198 )
2013
27
Pediatric sciatic neuropathy presenting as painful leg: A case report and review of literature. ( 24082941 )
2013
28
Sciatic neuropathy after extruded cement from cementoplasty. ( 22698999 )
2012
29
Bilateral sciatic neuropathy as a complication of craniotomy performed in the sitting position: localization of nerve injury by using magnetic resonance imaging. ( 21956785 )
2012
30
Experimental study of the etiology and pathogenesis of sciatic neuropathy under conditions of therapy for ischium fractures. ( 22803181 )
2012
31
Bilateral sciatic neuropathy in dogs caused by spontaneous muscular and intraneural hemorrhage. ( 22742071 )
2012
32
3-T high-resolution MR neurography of sciatic neuropathy. ( 22451573 )
2012
33
Minocycline injection in the ventral posterolateral thalamus reverses microglial reactivity and thermal hyperalgesia secondary to sciatic neuropathy. ( 21571034 )
2011
34
Pediatric sciatic neuropathy associated with neoplasms. ( 21254082 )
2011
35
Vascular malformations, rare causes of sciatic neuropathy: a case series. ( 20881578 )
2010
36
Sciatic neuropathy after body contouring surgery in massive weight loss patients. ( 19703796 )
2010
37
Postpartum septic sacroiliitis misdiagnosed as sciatic neuropathy. ( 20090512 )
2010
38
A treatment option for post-injection sciatic neuropathy: transsacral block with methylprednisolone. ( 20859314 )
2010
39
Delayed sciatic neuropathy after distal semimembranosus muscle rupture associated with tethering of the sciatic nerve by a rare distal muscular branch. ( 19193374 )
2009
40
Forceful stretching of the hamstrings at what expense? Sciatic neuropathy in a child. ( 19787185 )
2009
41
Post-radiation sciatic neuropathy: a case report and review of the literature. ( 19077234 )
2008
42
Deep venous thrombosis and inferior vena cava agenesis causing double crush sciatic neuropathy in BehAset's disease. ( 18848486 )
2008
43
Cryoglobulinaemic neuropathy: a further cause of bilateral sciatic neuropathy. ( 18834546 )
2008
44
Governing role of primary afferent drive in increased excitation of spinal nociceptive neurons in a model of sciatic neuropathy. ( 18773893 )
2008
45
Sciatic neuropathy from a giant hibernoma of the thigh: a case report. ( 18587508 )
2008
46
Sciatic neuropathy after lower-extremity trauma: successful treatment of an uncommon pain and disability syndrome in an adolescent. ( 17581294 )
2007
47
Duration of preoperative traction associated with sciatic neuropathy after hip fracture surgery. ( 16601417 )
2006
48
Intravenous use of buprenorphine tablets associated with rhabdomyolysis and compressive sciatic neuropathy. ( 16546629 )
2006
49
Sciatic neuropathy following endovascular treatment of a limb vascular malformation. ( 17173687 )
2006
50
Sciatic neuropathy: case report and discussion of the literature on postoperative sciatic neuropathy and sciatic nerve tumors. ( 18751834 )
2006

Variations for Sciatic Neuropathy

Expression for Sciatic Neuropathy

Search GEO for disease gene expression data for Sciatic Neuropathy.

Pathways for Sciatic Neuropathy

Pathways related to Sciatic Neuropathy according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 NGF NOTCH1 PDGFB TJP1 TNFRSF1A TNFRSF1B
2
Show member pathways
12.33 PDGFB TNFRSF1A TNFRSF1B TNFRSF9
3
Show member pathways
12.33 NGF PDGFB TNFRSF1A TNFRSF1B
4
Show member pathways
12.29 NGF TNFRSF1A TNFRSF1B TNFRSF9
5
Show member pathways
11.68 NGF PDGFB TNFRSF1A TNFRSF1B
6 11.4 NGF NOTCH1 PDGFB
7
Show member pathways
11.3 NGF TNFRSF1A TNFRSF1B
8 11.01 TNFRSF1A TNFRSF1B
9 10.98 NGF TRPV1
10 10.64 NGF TNFRSF1A TNFRSF1B
11 10.28 TNFRSF1A TNFRSF1B TNFRSF9

GO Terms for Sciatic Neuropathy

Cellular components related to Sciatic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor superfamily complex GO:0002947 8.62 TNFRSF1A TNFRSF1B

Biological processes related to Sciatic Neuropathy according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.65 NOTCH1 TJP1 TNFRSF1B
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.58 TNFRSF1A TNFRSF1B TNFRSF9
3 cellular response to growth factor stimulus GO:0071363 9.54 PDGFB TNFRSF1B TRPV1
4 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.49 NGF TNFRSF1A
5 cardiac muscle tissue morphogenesis GO:0055008 9.46 MYOM2 NOTCH1
6 positive regulation of Ras protein signal transduction GO:0046579 9.43 NGF NOTCH1
7 negative regulation of cardiac muscle hypertrophy GO:0010614 9.33 NOTCH1 TNFRSF1A TNFRSF1B
8 aortic valve development GO:0003176 9.32 TNFRSF1A TNFRSF1B
9 pulmonary valve development GO:0003177 9.26 TNFRSF1A TNFRSF1B
10 negative regulation of extracellular matrix constituent secretion GO:0003332 9.13 NOTCH1 TNFRSF1A TNFRSF1B
11 positive regulation of apoptotic process involved in morphogenesis GO:1902339 8.8 NOTCH1 TNFRSF1A TNFRSF1B

Molecular functions related to Sciatic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.33 TJP1 TRPV1 USP6
2 tumor necrosis factor-activated receptor activity GO:0005031 8.96 TNFRSF1A TNFRSF1B
3 tumor necrosis factor binding GO:0043120 8.62 TNFRSF1A TNFRSF1B

Sources for Sciatic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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