Aliases & Classifications for Sciatic Neuropathy

MalaCards integrated aliases for Sciatic Neuropathy:

Name: Sciatic Neuropathy 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11446
MeSH 44 D020426
SNOMED-CT 68 52585001
UMLS 73 C0149940

Summaries for Sciatic Neuropathy

MalaCards based summary : Sciatic Neuropathy is related to plexopathy and paroxysmal extreme pain disorder, and has symptoms including sciatica An important gene associated with Sciatic Neuropathy is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are PAK Pathway and NF-KappaB Family Pathway. The drugs Acetaminophen and Morphine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, thalamus and b cells, and related phenotypes are cardiovascular system and integument

Related Diseases for Sciatic Neuropathy

Diseases related to Sciatic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 plexopathy 30.0 NGF NOTCH1
2 paroxysmal extreme pain disorder 10.7 SCN10A TRPV1
3 neuropathy 10.7
4 trigeminal neuralgia 10.6 SCN10A TRPV1
5 cough variant asthma 10.6 NGF TRPV1
6 mononeuropathy 10.6 MYOM2 TRPV1
7 burning mouth syndrome 10.5 NGF TRPV1
8 mononeuritis of lower limb 10.5 SCN10A TRPV1 USP6
9 subclavian steal syndrome 10.4 KANTR NOTCH1
10 substernal goiter 10.4 KANTR NOTCH1
11 chronic gonococcal salpingitis 10.4 TNFRSF1A TNFRSF1B
12 petroclival meningioma 10.4 KANTR NOTCH1
13 pericoronitis 10.4 TNFRSF1A TNFRSF1B
14 brachial plexus neuritis 10.4 KANTR NOTCH1
15 paine syndrome 10.4 NGF SCN10A TRPV1
16 neuroma 10.3 NGF SCN10A TRPV1
17 periodic fever, familial, autosomal dominant 10.3 TNFRSF1A TNFRSF1B
18 optic disk drusen 10.3 KANTR NOTCH1
19 short-rib thoracic dysplasia 5 with or without polydactyly 10.2 TNFRSF1A TNFRSF1B
20 sweat gland disease 10.2 NGF TNFRSF1B
21 acute salpingitis 10.2 TNFRSF1A TNFRSF1B
22 post-transplant lymphoproliferative disease 10.2 TNFRSF1A TNFRSF1B
23 cochlear disease 10.1 KANTR TNFRSF1B
24 lesion of sciatic nerve 10.1 NGF SCN10A TRPV1 USP6
25 dystonia 1, torsion, autosomal dominant 10.1 KANTR NOTCH1
26 cardiovascular organ benign neoplasm 10.0 KANTR TRPV1
27 central nervous system disease 10.0 KANTR NGF TRPV1
28 nervous system disease 10.0 KANTR NGF TRPV1
29 alveolar periostitis 10.0 KANTR TNFRSF9
30 benign perivascular tumor 9.9 KANTR TRPV1
31 thrombosis 9.9
32 compartment syndrome 9.9
33 aneurysm 9.9
34 chronic salpingitis 9.8 KANTR TNFRSF1A TNFRSF1B
35 aortic aneurysm, familial abdominal, 1 9.7
36 neuropathy, hereditary, with liability to pressure palsies 9.7
37 thrombophilia due to thrombin defect 9.7
38 arthritis 9.7
39 b-cell lymphomas 9.7
40 brain injury 9.7
41 breast reconstruction 9.7
42 diabetes mellitus 9.7
43 traumatic brain injury 9.7
44 lymphoma 9.7
45 ehlers-danlos syndrome 9.7
46 vaginitis 9.7
47 bursitis 9.7
48 aortic aneurysm 9.7
49 neuronitis 9.7
50 septic arthritis 9.7

Graphical network of the top 20 diseases related to Sciatic Neuropathy:



Diseases related to Sciatic Neuropathy

Symptoms & Phenotypes for Sciatic Neuropathy

UMLS symptoms related to Sciatic Neuropathy:


sciatica

MGI Mouse Phenotypes related to Sciatic Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 NGF TRPV1 NOTCH1 PDGFB SCN10A TJP1
2 integument MP:0010771 9.86 TNFRSF9 NGF TRPV1 NOTCH1 PDGFB SCN10A
3 no phenotypic analysis MP:0003012 9.63 TNFRSF9 NGF TRPV1 PDGFB SCN10A TNFRSF1A
4 renal/urinary system MP:0005367 9.5 TNFRSF9 TRPV1 NOTCH1 PDGFB TJP1 TNFRSF1A
5 vision/eye MP:0005391 9.1 TNFRSF9 NGF NOTCH1 PDGFB TNFRSF1A TNFRSF1B

Drugs & Therapeutics for Sciatic Neuropathy

Drugs for Sciatic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 126)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
3
Ibuprofen Approved Phase 4 15687-27-1 3672
4
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Early Phase 1 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Early Phase 1 50-24-8 5755
7
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
8 Analgesics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
9 Analgesics, Non-Narcotic Phase 4,Phase 1,Phase 2,Not Applicable
10 Analgesics, Opioid Phase 4,Phase 3,Phase 2,Not Applicable
11 Antipyretics Phase 4
12 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Narcotics Phase 4,Phase 3,Phase 2,Not Applicable
14 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
15 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 1,Phase 2,Not Applicable
17 Antirheumatic Agents Phase 4,Phase 2,Phase 1,Not Applicable
18 Cyclooxygenase Inhibitors Phase 4,Not Applicable
19 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Gastrointestinal Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
23 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Methylprednisolone acetate Phase 4,Phase 3,Early Phase 1
28 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Early Phase 1
29 Neuroprotective Agents Phase 4,Phase 3,Phase 2
30 Prednisolone acetate Phase 4,Phase 3,Early Phase 1
31 Prednisolone hemisuccinate Phase 4,Phase 3,Early Phase 1
32 Prednisolone phosphate Phase 4,Phase 3,Early Phase 1
33 Protective Agents Phase 4,Phase 3,Phase 2
34
Meperidine Approved Phase 3 57-42-1 4058
35
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
36
Oxycodone Approved, Illicit, Investigational Phase 3 76-42-6 5284603
37
Menthol Approved Phase 3,Not Applicable 2216-51-5 16666
38
Lidocaine Approved, Vet_approved Phase 3,Phase 2,Phase 1,Early Phase 1 137-58-6 3676
39 Cortivazol Investigational Phase 3 1110-40-3
40 Adjuvants, Anesthesia Phase 3
41 Anesthetics Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
42 Adrenergic Agents Phase 3,Phase 2
43 Adrenergic alpha-Antagonists Phase 3
44 Adrenergic Antagonists Phase 3
45 Neurotransmitter Agents Phase 3,Phase 2,Not Applicable
46 Anesthetics, Local Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Anti-Arrhythmia Agents Phase 3,Phase 1
48 Diuretics, Potassium Sparing Phase 3,Phase 1
49 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable
50 Sodium Channel Blockers Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 71)
# Name Status NCT ID Phase Drugs
1 IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia Unknown status NCT02504996 Phase 4 Paracetamol;morphine;Placebo
2 Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Department Unknown status NCT02777320 Phase 4 paracetamol;Ibuprofen
3 Safety and Efficacy of Nonsteroidal Antiinflammatory (NSAI)Drug and Glucocorticoids in Acute Sciatica Completed NCT01816334 Phase 4 methylprednisolone;Ketoprofen;Sodium Chloride
4 Herniectomy Versus Herniectomy With a Spinal Stabilization System for the Treatment of Complex Disc Disease Completed NCT00749996 Phase 4
5 NSAIDs in Sciatica NSAIDS IN SCIATICA Recruiting NCT03347929 Phase 4 Naproxen 500 Mg;Placebo
6 Ultrasound-guided Caudal or Interlaminar Corticosteroid Epidural Injection for Sciatica Recruiting NCT02897336 Phase 4
7 Comparison of a Cortivazol (ALTIM®) Infiltration of Posterior Epidural Space at L3-L4 Stage Versus an Epidural Infiltration of Cortivazol (ALTIM®) on Contact With Disco Radicular Conflict in Discal Sciatica Unknown status NCT02151045 Phase 3
8 Neuraxial Pethidine After Lumbar Surgery Trial Unknown status NCT00163553 Phase 3 Pethidine;Placebo
9 Physiotherapy for Sciatica; Is Earlier Better? Completed NCT02618278 Phase 3
10 The Value of Traction in Treatment of Lumbar Radiculopathy Completed NCT00942227 Phase 3
11 The Efficacy of Oral Steroids in the Treatment of Acute Sciatica Completed NCT00317447 Phase 3 Oral Prednisone
12 Lumbar Spinal Fibrosis and TNF Alpha Inhibition Completed NCT00385086 Phase 3 TNF blocker;Placebo
13 A Study to Evaluate 90-Day Safety of Tapentadol(CG5503) Immediate Release (IR) or Oxycodone Immediate Release in Patients With Chronic Pain Completed NCT00364546 Phase 3 CG 5503;tapentadol
14 Management Strategies for Patients With Low Back Pain and Sciatica Recruiting NCT02391350 Phase 3
15 Efficacy of corticoïd Infiltration Via Sacro-coccygien Hiatus in Discal Sciatica Terminated NCT01482897 Phase 3 Prednisolone acetate;sham procedure;comparator : physiological solution
16 Study of REN-1654 in Patients With Sciatica Pain Unknown status NCT00107055 Phase 2 REN-1654
17 Effectiveness Study of Physical Therapy as an Adjunct to a Lumbar Therapeutic Selective Nerve Root Block Completed NCT00934284 Phase 2
18 A Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of MDT-15 in Subjects With Lumbosacral Radiculopathy Completed NCT01917825 Phase 2 MDT-15
19 Study to Evaluate the Safety and Efficacy of Placulumab (CEP-37247) Administered by the Transforaminal Epidural Route for the Treatment of Patients With Lumbosacral Radicular Pain Associated With Disk Herniation Completed NCT01240876 Phase 1, Phase 2 CEP-37247;Placebo
20 BG00010 (Neublastin) Phase 2 Multiple Dose Adaptive Design in Participants With Painful Lumbar Radiculopathy Completed NCT01873404 Phase 2 BG00010;Placebo
21 A Study to Evaluate the Safety and Efficacy of Subcutaneously Administered REGN475(SAR164877) in Patients With Sciatic Pain Completed NCT00991172 Phase 2 REGN475;REGN475;Placebo Injection
22 Effectiveness of Oral Prednisone in Improving Physical Functioning and Decreasing Pain in People With Sciatica Completed NCT00668434 Phase 2 Prednisone;Placebo
23 Adalimumab in Severe and Acute Sciatica Completed NCT00470509 Phase 2 adalimumab (2 subcutaneous 40 mg injections on day 0 and 7)
24 Manipulation or Microdiscectomy For Sciatica? A Prospective Randomized Controlled Trial. Completed NCT00415220 Phase 2
25 Efficacy of Epidural Etanercept in the Treatment of Sciatica Completed NCT00364572 Phase 1, Phase 2 epidural injection of etanercept;placebo (control procedure)
26 Topiramate in the Treatment of Sciatica Completed NCT00011804 Phase 2 Topiramate
27 Magnets in the Treatment of Sciatica Completed NCT00044109 Phase 2
28 Effect of Antidepressants on Back Pain Completed NCT00018200 Phase 2 Desipramine;Fluoxetine;Benztropine
29 Pain Treatment for Sciatica Completed NCT00009672 Phase 2 Nortriptyline;Morphine
30 A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain Recruiting NCT03240783 Phase 2 Betamethasone OR Dexamethasone Injectable;Normal Saline Flush, 0.9% Injectable Solution;Dexamethasone Oral Tablet
31 Energy Specific Far Infrared Radiation Treatment for Sciatica Unknown status NCT00573807 Phase 1
32 Clinical Trial to Evaluate the Safety and Analgesic Efficacy of VVZ-149 in Lumbar Radiculopathy (Sciatica) Completed NCT02644421 Phase 1 VVZ-149;Lidocaine;Placebo
33 Study of the Safety, Tolerability, Pharmacokinetics and Safety of BG00010 (Neublastin) in Subjects With Sciatica. Completed NCT01405833 Phase 1 BG00010 (Neublastin);Placebo
34 Evaluate the Safety, Tolerability and Pharmacokinetics of BG00010 (Neublastin) Administered to Sciatica Participants Completed NCT00961766 Phase 1 BG00010 (Neublastin);Placebo
35 Mechanical Diagnosis and Treatment and/or Steroid Injections for Lumbar Radiculopathy Not yet recruiting NCT02951377 Phase 1 Transforaminal epidural steroid injection (20mg dexamethasone 0.5cc lidocaine 2%)
36 Efficacy of Acupuncture for Discogenic Sciatica Unknown status NCT02770963 Not Applicable
37 "The Lived Experience of Investigations for Sciatica" Unknown status NCT02512081
38 Electroacupuncture for Sciatica Due to Intervertebral Disc Displacement Unknown status NCT02087462 Not Applicable Voltaren;Vitamin B1
39 Pain Relief by Platelet-rich Plasma (PRP) Treatment Unknown status NCT01749839
40 Efficacy of Intravenous Dexamethasone for Acute Disc Herniation-Induced Sciatica Unknown status NCT00516009 Not Applicable DEXAMETHASONE
41 Neuromuscular Ultrasound for Focal Neuropathies Completed NCT01394822
42 The Effectiveness of Neurodynamic Techniques in Patients With Nerve-Related Leg Pain Completed NCT01954199 Not Applicable
43 Outcome of Surgery for Sciatica - a Comparison of Data From Three National Quality Registries Completed NCT02889484
44 Long-Term Course of Korean Medicine Treatment for Lumbar Disc Herniation Completed NCT03426215
45 Effects of Shinbaro Pharmacopuncture in Sciatic Pain Patients With Lumbar Disc Herniation Completed NCT02384928 Not Applicable Conventional medicine
46 Alternative and Integrative Therapy for Lumbar Disk Herniation Completed NCT01989403
47 Long-term Outcomes of Surgical and Nonsurgical Management of Sciatica Secondary to a Lumbar Disc Herniation or Spinal Stenosis Completed NCT02836730
48 [18F]FTC-146 PET/MRI in Healthy Volunteers and in CRPS and Sciatica Completed NCT02753101 Early Phase 1 [18F]-FTC-146
49 Effects of Control Scan for Presumed Difficult Epidural Infiltrations (ECHORACHIS) Completed NCT01832844 Not Applicable
50 NAPS: Non-awake Versus Awake Placement of Spinal Cord Stimulators Completed NCT02284542

Search NIH Clinical Center for Sciatic Neuropathy

Cochrane evidence based reviews: sciatic neuropathy

Genetic Tests for Sciatic Neuropathy

Anatomical Context for Sciatic Neuropathy

MalaCards organs/tissues related to Sciatic Neuropathy:

41
Spinal Cord, Thalamus, B Cells, Brain

Publications for Sciatic Neuropathy

Articles related to Sciatic Neuropathy:

(show top 50) (show all 91)
# Title Authors Year
1
Sciatic neuropathy and rhabdomyolysis after carbon monoxide intoxication: A case report. ( 29879074 )
2018
2
Bilateral Sciatic Neuropathy following Gluteal Augmentation With Autologous Fat Grafting. ( 29707455 )
2018
3
Sciatic neuropathy: findings on magnetic resonance neurography. ( 28670031 )
2017
4
Sciatic neuropathy due to popliteal fossa nerve block. ( 28214338 )
2017
5
Chronic Sciatic Neuropathy in Rat Reduces Voluntary Wheel-Running Activity With Concurrent Chronic Mechanical Allodynia. ( 27782944 )
2017
6
Bilateral Sciatic Neuropathy after an Autologous Breast Reconstruction in a Massive Weight Loss Patient. ( 28203505 )
2017
7
Isolated sciatic neuropathy as an initial manifestation of a high grade B-cell lymphoma: A case report and literature review. ( 27540756 )
2016
8
Preventive Effects of the Chinese Herbal Medicine Prescription Tangkuei Decoction for Frigid Extremities on Sciatic Neuropathy in Streptozotocin-Induced Diabetic Rats. ( 27057201 )
2016
9
Synovial cyst of the knee: A rare case of acute sciatic neuropathy. ( 27659236 )
2016
10
Sequential Early and Delayed Painful Sciatic Neuropathy Following Revision Total Hip Arthroplasty. ( 26990207 )
2016
11
Sciatic neuropathy developed after injection during curettage. ( 27225613 )
2016
12
Irreversible electroporation-induced sciatic neuropathy observed by intraoperative neuromonitoring. ( 27417051 )
2016
13
Postpartum sciatic neuropathy: Segmental fractional anisotropy analysis to disclose neurapraxia. ( 27572428 )
2016
14
Early diagnosis of Varicella-zoster virus sciatic neuropathy by MRI neurography. ( 27625277 )
2016
15
Bilateral sciatic neuropathy misdiagnosed as critical illness neuropathy: a case report. ( 25990100 )
2015
16
Sciatic Neuropathy Caused by Focal Venous Engorgement Associated With Deep Vein Thrombosis: A Case Report. ( 26079864 )
2015
17
Right calf claudication revealing leriche syndrome presenting as right sciatic neuropathy. ( 24639938 )
2014
18
Hereditary neuropathy with liability to pressure palsies presenting with sciatic neuropathy. ( 25326571 )
2014
19
Severe isolated sciatic neuropathy due to a modified lotus position. ( 24579070 )
2014
20
Post-injection sciatic neuropathy in a cynomolgus macaque (Macaca fascicularis). ( 24236754 )
2014
21
Gluteal Compartment Syndrome Complicated with Bilateral Sciatic Neuropathy. ( 26077186 )
2014
22
Bilateral sciatic neuropathy due to fibrous bands in a patient with severe traumatic brain injury. ( 24731584 )
2014
23
Teaching NeuroImages: sciatic neuropathy after heroin abuse. ( 23960198 )
2013
24
Pediatric sciatic neuropathy presenting as painful leg: A case report and review of literature. ( 24082941 )
2013
25
Sciatic neuropathy after extruded cement from cementoplasty. ( 22698999 )
2012
26
Bilateral sciatic neuropathy as a complication of craniotomy performed in the sitting position: localization of nerve injury by using magnetic resonance imaging. ( 21956785 )
2012
27
Experimental study of the etiology and pathogenesis of sciatic neuropathy under conditions of therapy for ischium fractures. ( 22803181 )
2012
28
Bilateral sciatic neuropathy in dogs caused by spontaneous muscular and intraneural hemorrhage. ( 22742071 )
2012
29
3-T high-resolution MR neurography of sciatic neuropathy. ( 22451573 )
2012
30
Minocycline injection in the ventral posterolateral thalamus reverses microglial reactivity and thermal hyperalgesia secondary to sciatic neuropathy. ( 21571034 )
2011
31
Pediatric sciatic neuropathy associated with neoplasms. ( 21254082 )
2011
32
Vascular malformations, rare causes of sciatic neuropathy: a case series. ( 20881578 )
2010
33
Sciatic neuropathy after body contouring surgery in massive weight loss patients. ( 19703796 )
2010
34
Postpartum septic sacroiliitis misdiagnosed as sciatic neuropathy. ( 20090512 )
2010
35
A treatment option for post-injection sciatic neuropathy: transsacral block with methylprednisolone. ( 20859314 )
2010
36
Delayed sciatic neuropathy after distal semimembranosus muscle rupture associated with tethering of the sciatic nerve by a rare distal muscular branch. ( 19193374 )
2009
37
Forceful stretching of the hamstrings at what expense? Sciatic neuropathy in a child. ( 19787185 )
2009
38
Post-radiation sciatic neuropathy: a case report and review of the literature. ( 19077234 )
2008
39
Deep venous thrombosis and inferior vena cava agenesis causing double crush sciatic neuropathy in BehAset's disease. ( 18848486 )
2008
40
Cryoglobulinaemic neuropathy: a further cause of bilateral sciatic neuropathy. ( 18834546 )
2008
41
Governing role of primary afferent drive in increased excitation of spinal nociceptive neurons in a model of sciatic neuropathy. ( 18773893 )
2008
42
Sciatic neuropathy after lower-extremity trauma: successful treatment of an uncommon pain and disability syndrome in an adolescent. ( 17581294 )
2007
43
Duration of preoperative traction associated with sciatic neuropathy after hip fracture surgery. ( 16601417 )
2006
44
Intravenous use of buprenorphine tablets associated with rhabdomyolysis and compressive sciatic neuropathy. ( 16546629 )
2006
45
Sciatic neuropathy following endovascular treatment of a limb vascular malformation. ( 17173687 )
2006
46
Sciatic neuropathy: case report and discussion of the literature on postoperative sciatic neuropathy and sciatic nerve tumors. ( 18751834 )
2006
47
A case of sciatic neuropathy after caesarean section under spinal anaesthesia. ( 16774831 )
2006
48
HNPP presenting as sciatic neuropathy. ( 15703012 )
2005
49
Traumatic venous varix causing sciatic neuropathy: case report. ( 15791740 )
2004
50
Use of an ankle-foot orthosis in a dog with traumatic sciatic neuropathy. ( 12779177 )
2003

Variations for Sciatic Neuropathy

Expression for Sciatic Neuropathy

Search GEO for disease gene expression data for Sciatic Neuropathy.

Pathways for Sciatic Neuropathy

GO Terms for Sciatic Neuropathy

Biological processes related to Sciatic Neuropathy according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.78 NOTCH1 TNFRSF1A TNFRSF1B TNFRSF9
2 inflammatory response GO:0006954 9.73 TNFRSF1A TNFRSF1B TNFRSF9 TRPV1
3 positive regulation of MAPK cascade GO:0043410 9.63 PDGFB TNFRSF1A TNFRSF1B
4 tumor necrosis factor-mediated signaling pathway GO:0033209 9.54 TNFRSF1A TNFRSF1B TNFRSF9
5 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.49 NGF TNFRSF1A
6 regulation of cell proliferation GO:0042127 9.46 NOTCH1 TNFRSF1A TNFRSF1B TNFRSF9
7 apoptotic signaling pathway GO:0097190 9.43 TNFRSF1A TNFRSF1B TNFRSF9
8 positive regulation of Ras protein signal transduction GO:0046579 9.4 NGF NOTCH1
9 cardiac muscle tissue morphogenesis GO:0055008 9.32 MYOM2 NOTCH1
10 cellular response to growth factor stimulus GO:0071363 9.13 PDGFB TNFRSF1B TRPV1
11 response to lipopolysaccharide GO:0032496 9.02 NOTCH1 TJP1 TNFRSF1A TNFRSF1B TNFRSF9

Molecular functions related to Sciatic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.13 TJP1 TRPV1 USP6
2 tumor necrosis factor-activated receptor activity GO:0005031 8.8 TNFRSF1A TNFRSF1B TNFRSF9

Sources for Sciatic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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