Aliases & Classifications for Sciatic Neuropathy

MalaCards integrated aliases for Sciatic Neuropathy:

Name: Sciatic Neuropathy 12 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11446
MeSH 45 D020426
SNOMED-CT 69 52585001
UMLS 74 C0149940

Summaries for Sciatic Neuropathy

MalaCards based summary : Sciatic Neuropathy is related to neuropathy and paroxysmal extreme pain disorder, and has symptoms including sciatica An important gene associated with Sciatic Neuropathy is SH3TC2 (SH3 Domain And Tetratricopeptide Repeats 2), and among its related pathways/superpathways are PAK Pathway and 4-1BB Pathway. The drugs Morphine and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Sciatic Neuropathy

Diseases related to Sciatic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 neuropathy 10.9
2 paroxysmal extreme pain disorder 10.3 SCN10A TRPV1
3 mononeuritis of lower limb 10.3 SCN10A TRPV1 USP6
4 autoimmune encephalitis 10.3 CNR1 TRPV1
5 mononeuropathy 10.3 MYOM2 SH3TC2 TRPV1
6 neurogenic arthropathy 10.2 MYOM2 NGF
7 cough variant asthma 10.2 NGF TRPV1
8 cannabis abuse 10.2 CNR1 CNR2 NGF
9 neuroma 10.2 NGF SCN10A TRPV1
10 bone cancer 10.2 CNR1 NOTCH1 TRPV1
11 substernal goiter 10.2 KANTR NOTCH1
12 familial cold autoinflammatory syndrome 1 10.2 IL1B TNFRSF1A
13 chronic gonococcal salpingitis 10.2 TNFRSF1A TNFRSF1B
14 subclavian steal syndrome 10.2 KANTR NOTCH1
15 stomach disease 10.1 IL1B SCN10A TRPV1
16 diabetic neuropathy 10.1 CNR1 NGF TRPV1
17 upper respiratory tract disease 10.1 IL1B MYOM2 TRPV1
18 uremic pruritus 10.1 CNR1 IL1B
19 mouth disease 10.1 IL1B NOTCH1 TRPV1
20 lesion of sciatic nerve 10.1 NGF SCN10A TRPV1 USP6
21 petroclival meningioma 10.1 KANTR NOTCH1
22 somatoform disorder 10.1 IL1B NGF TRPV1
23 toxic encephalopathy 10.1 IL1B NGF TRPV1
24 pain agnosia 10.1 CNR1 RPL34 TRPV1
25 agnosia 10.1 CNR1 RPL34 TRPV1
26 brachial plexus neuritis 10.0 KANTR NOTCH1
27 specific developmental disorder 10.0 CNR1 RPL34 TRPV1
28 bone structure disease 10.0 IL1B RPL34 SH3TC2
29 bone inflammation disease 10.0 IL1B TNFRSF1B TRPV1
30 thrombosis 10.0
31 compartment syndrome 10.0
32 pericoronitis 10.0 IL1B TNFRSF1A TNFRSF1B
33 palindromic rheumatism 10.0 IL1B TNFRSF1A TNFRSF1B
34 paine syndrome 10.0 IL1B NGF SCN10A TRPV1
35 arteries, anomalies of 10.0 IL1B KANTR TRPV1
36 migraine with or without aura 1 9.9 CNR1 KANTR TRPV1
37 chronic salpingitis 9.9 KANTR TNFRSF1A TNFRSF1B
38 central nervous system disease 9.9 CNR1 IL1B NGF TRPV1
39 cochlear disease 9.9 KANTR TNFRSF1B
40 aortic aneurysm, familial abdominal, 1 9.9
41 lipomatosis, multiple 9.9
42 neuropathy, hereditary, with liability to pressure palsies 9.9
43 thrombophilia due to thrombin defect 9.9
44 arthritis 9.9
45 brain injury 9.9
46 breast reconstruction 9.9
47 diabetes mellitus 9.9
48 traumatic brain injury 9.9
49 lymphoma 9.9
50 pleomorphic lipoma 9.9

Graphical network of the top 20 diseases related to Sciatic Neuropathy:



Diseases related to Sciatic Neuropathy

Symptoms & Phenotypes for Sciatic Neuropathy

UMLS symptoms related to Sciatic Neuropathy:


sciatica

MGI Mouse Phenotypes related to Sciatic Neuropathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 CNR1 DLG4 IL1B NGF NOTCH1 PDGFB
2 growth/size/body region MP:0005378 10.11 CNR1 DLG4 IL1B NGF NOTCH1 PDGFB
3 cardiovascular system MP:0005385 10.1 IL1B NGF NOTCH1 PDGFB SCN10A SH3TC2
4 integument MP:0010771 10.03 CNR1 CNR2 DLG4 IL1B NGF NOTCH1
5 nervous system MP:0003631 9.93 CNR1 DLG4 IL1B NGF NOTCH1 PDGFB
6 no phenotypic analysis MP:0003012 9.5 CNR1 NGF PDGFB SCN10A TNFRSF1A TNFRSF9
7 renal/urinary system MP:0005367 9.17 NOTCH1 PDGFB TJP1 TNFRSF1A TNFRSF1B TNFRSF9

Drugs & Therapeutics for Sciatic Neuropathy

Drugs for Sciatic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 130)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Ibuprofen Approved Phase 4 15687-27-1 3672
4
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
5
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 302-25-0
6
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Not Applicable,Early Phase 1 2921-57-5
7
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 50-24-8 5755
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 83-43-2 6741
9
Naproxen Approved, Vet_approved Phase 4 22204-53-1 156391 1302
10
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Not Applicable,Early Phase 1 2920-86-7
11 Narcotics Phase 4,Phase 3,Phase 2,Not Applicable
12 Antipyretics Phase 4
13 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
14 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 1,Not Applicable
16 Analgesics, Opioid Phase 4,Phase 3,Phase 2,Not Applicable
17 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 1,Phase 2,Not Applicable
19 Cyclooxygenase Inhibitors Phase 4,Not Applicable
20 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
21 Antirheumatic Agents Phase 4,Phase 2,Phase 1,Not Applicable
22 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
23 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
25 Gastrointestinal Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
26 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Protective Agents Phase 4,Phase 3,Not Applicable,Early Phase 1
31 Methylprednisolone Acetate Phase 4,Phase 3,Not Applicable,Early Phase 1
32 Prednisolone acetate Phase 4,Phase 3,Not Applicable,Early Phase 1
33 Neuroprotective Agents Phase 4,Phase 3,Not Applicable,Early Phase 1
34
Meperidine Approved Phase 3 57-42-1 4058
35
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
36
Oxycodone Approved, Illicit, Investigational Phase 3 76-42-6 5284603
37
Tapentadol Approved Phase 3 175591-23-8 9838022
38
Lidocaine Approved, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
39 Cortivazol Investigational Phase 3 1110-40-3
40 Anesthetics Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
41 Adjuvants, Anesthesia Phase 3
42 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
43 Adrenergic Antagonists Phase 3
44 Adrenergic alpha-Antagonists Phase 3
45 Adrenergic Agents Phase 3,Phase 2
46 Neurotransmitter Agents Phase 3,Phase 2,Not Applicable
47 Neurotransmitter Uptake Inhibitors Phase 3,Phase 2
48 Anesthetics, Local Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
49 Diuretics, Potassium Sparing Phase 3,Phase 1,Not Applicable
50 Anti-Arrhythmia Agents Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 79)
# Name Status NCT ID Phase Drugs
1 Ultrasound-guided Caudal or Interlaminar Corticosteroid Epidural Injection for Sciatica Unknown status NCT02897336 Phase 4
2 IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia Unknown status NCT02504996 Phase 4 Paracetamol;morphine;Placebo
3 Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Department Unknown status NCT02777320 Phase 4 paracetamol;Ibuprofen
4 Safety and Efficacy of Nonsteroidal Antiinflammatory (NSAI)Drug and Glucocorticoids in Acute Sciatica Completed NCT01816334 Phase 4 methylprednisolone;Ketoprofen;Sodium Chloride
5 Herniectomy Versus Herniectomy With a Spinal Stabilization System for the Treatment of Complex Disc Disease Completed NCT00749996 Phase 4
6 NSAIDs in Sciatica NSAIDS IN SCIATICA Recruiting NCT03347929 Phase 4 Naproxen 500 Mg;Placebo
7 Comparison of a Cortivazol (ALTIM®) Infiltration of Posterior Epidural Space at L3-L4 Stage Versus an Epidural Infiltration of Cortivazol (ALTIM®) on Contact With Disco Radicular Conflict in Discal Sciatica Unknown status NCT02151045 Phase 3
8 Neuraxial Pethidine After Lumbar Surgery Trial Unknown status NCT00163553 Phase 3 Pethidine;Placebo
9 The Efficacy of Oral Steroids in the Treatment of Acute Sciatica Completed NCT00317447 Phase 3 Oral Prednisone
10 Lumbar Spinal Fibrosis and TNF Alpha Inhibition Completed NCT00385086 Phase 3 TNF blocker;Placebo
11 The Value of Traction in Treatment of Lumbar Radiculopathy Completed NCT00942227 Phase 3
12 Physiotherapy for Sciatica; Is Earlier Better? Completed NCT02618278 Phase 3
13 A Study to Evaluate 90-Day Safety of Tapentadol(CG5503) Immediate Release (IR) or Oxycodone Immediate Release in Patients With Chronic Pain Completed NCT00364546 Phase 3 CG 5503;tapentadol
14 Efficacy of corticoïd Infiltration Via Sacro-coccygien Hiatus in Discal Sciatica Terminated NCT01482897 Phase 3 Prednisolone acetate;sham procedure;comparator : physiological solution
15 Study of REN-1654 in Patients With Sciatica Pain Unknown status NCT00107055 Phase 2 REN-1654
16 Effectiveness Study of Physical Therapy as an Adjunct to a Lumbar Therapeutic Selective Nerve Root Block Completed NCT00934284 Phase 2
17 Study to Evaluate the Safety and Efficacy of Placulumab (CEP-37247) Administered by the Transforaminal Epidural Route for the Treatment of Patients With Lumbosacral Radicular Pain Associated With Disk Herniation Completed NCT01240876 Phase 1, Phase 2 CEP-37247;Placebo
18 A Study to Evaluate the Safety and Efficacy of Subcutaneously Administered REGN475(SAR164877) in Patients With Sciatic Pain Completed NCT00991172 Phase 2 REGN475;REGN475;Placebo Injection
19 Effectiveness of Oral Prednisone in Improving Physical Functioning and Decreasing Pain in People With Sciatica Completed NCT00668434 Phase 2 Prednisone;Placebo
20 Adalimumab in Severe and Acute Sciatica Completed NCT00470509 Phase 2 Adalimumab;Placebos
21 Manipulation or Microdiscectomy For Sciatica? A Prospective Randomized Controlled Trial. Completed NCT00415220 Phase 2
22 Efficacy of Epidural Etanercept in the Treatment of Sciatica Completed NCT00364572 Phase 1, Phase 2 epidural injection of etanercept;placebo (control procedure)
23 Topiramate in the Treatment of Sciatica Completed NCT00011804 Phase 2 Topiramate
24 A Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of MDT-15 in Subjects With Lumbosacral Radiculopathy Completed NCT01917825 Phase 2 MDT-15
25 BG00010 (Neublastin) Phase 2 Multiple Dose Adaptive Design in Participants With Painful Lumbar Radiculopathy Completed NCT01873404 Phase 2 BG00010;Placebo
26 Magnets in the Treatment of Sciatica Completed NCT00044109 Phase 2
27 Effect of Antidepressants on Back Pain Completed NCT00018200 Phase 2 Desipramine;Fluoxetine;Benztropine
28 Pain Treatment for Sciatica Completed NCT00009672 Phase 2 Nortriptyline;Morphine
29 A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain Recruiting NCT03240783 Phase 2 Betamethasone OR Dexamethasone Injectable;Normal Saline Flush, 0.9% Injectable Solution;Dexamethasone Oral Tablet
30 Energy Specific Far Infrared Radiation Treatment for Sciatica Unknown status NCT00573807 Phase 1
31 Study of the Safety, Tolerability, Pharmacokinetics and Safety of BG00010 (Neublastin) in Subjects With Sciatica. Completed NCT01405833 Phase 1 BG00010 (Neublastin);Placebo
32 Evaluate the Safety, Tolerability and Pharmacokinetics of BG00010 (Neublastin) Administered to Sciatica Participants Completed NCT00961766 Phase 1 BG00010 (Neublastin);Placebo
33 Clinical Trial to Evaluate the Safety and Analgesic Efficacy of VVZ-149 in Lumbar Radiculopathy (Sciatica) Completed NCT02644421 Phase 1 VVZ-149;Lidocaine;Placebo
34 Mechanical Diagnosis and Treatment and/or Steroid Injections for Lumbar Radiculopathy Not yet recruiting NCT02951377 Phase 1 Transforaminal epidural steroid injection (20mg dexamethasone 0.5cc lidocaine 2%)
35 Efficacy of Acupuncture for Discogenic Sciatica Unknown status NCT02770963 Not Applicable
36 "The Lived Experience of Investigations for Sciatica" Unknown status NCT02512081
37 Intradiscal Discogel® in Resistant Sciatica Unknown status NCT02313350 Not Applicable
38 Electroacupuncture for Sciatica Due to Intervertebral Disc Displacement Unknown status NCT02087462 Not Applicable Voltaren;Vitamin B1
39 Pain Relief by Platelet-rich Plasma (PRP) Treatment Unknown status NCT01749839
40 Efficacy of Intravenous Dexamethasone for Acute Disc Herniation-Induced Sciatica Unknown status NCT00516009 Not Applicable DEXAMETHASONE
41 Chiropractic Spinal Manipulative Therapy for Acute Sciatica Secondary to Lumbar Disc Herniation Unknown status NCT01552486 Not Applicable
42 Neuromuscular Ultrasound for Focal Neuropathies Completed NCT01394822
43 Effectiveness of a Novel Neural Tissue Management to Improve Short-term Pain and Disability in Patients With Sciatica Completed NCT03663842 Not Applicable
44 Outcome of Surgery for Sciatica - a Comparison of Data From Three National Quality Registries Completed NCT02889484
45 Effects of Shinbaro Pharmacopuncture in Sciatic Pain Patients With Lumbar Disc Herniation Completed NCT02384928 Not Applicable Conventional medicine
46 Alternative and Integrative Therapy for Lumbar Disk Herniation Completed NCT01989403
47 Effects of Control Scan for Presumed Difficult Epidural Infiltrations (ECHORACHIS) Completed NCT01832844 Not Applicable
48 Kinesio Taping Technique and Trigger Point Completed NCT01752179 Not Applicable
49 High Versus Low Level of Lumbar Traction in Acute Lumbar Sciatica Due to Disc Herniation Completed NCT02091791 Not Applicable
50 The Efficacy of Active Conservative Treatment for Patients With Severe Sciatica. A Randomized Clinical Controlled Trial Completed NCT00246948 Not Applicable

Search NIH Clinical Center for Sciatic Neuropathy

Cochrane evidence based reviews: sciatic neuropathy

Genetic Tests for Sciatic Neuropathy

Anatomical Context for Sciatic Neuropathy

MalaCards organs/tissues related to Sciatic Neuropathy:

42
Brain, Bone, Testes, Spinal Cord, B Cells, Thalamus

Publications for Sciatic Neuropathy

Articles related to Sciatic Neuropathy:

(show top 50) (show all 97)
# Title Authors Year
1
Clinical and Electrodiagnostic Features Of Nontraumatic Sciatic Neuropathy. ( 30414322 )
2019
2
Sciatic neuropathy caused by a pressure ulcer: A case report. ( 30200159 )
2018
3
Bilateral sciatic neuropathy with severe rhabdomyolysis following venlafaxine overdose: A case report. ( 30212953 )
2018
4
Sciatic neuropathy and rhabdomyolysis after carbon monoxide intoxication: A case report. ( 29879074 )
2018
5
Bilateral Sciatic Neuropathy following Gluteal Augmentation With Autologous Fat Grafting. ( 29707455 )
2018
6
Sciatic neuropathy: findings on magnetic resonance neurography. ( 28670031 )
2017
7
Sciatic neuropathy due to popliteal fossa nerve block. ( 28214338 )
2017
8
Synovial cyst of the knee: A rare case of acute sciatic neuropathy. ( 27659236 )
2017
9
Chronic Sciatic Neuropathy in Rat Reduces Voluntary Wheel-Running Activity With Concurrent Chronic Mechanical Allodynia. ( 27782944 )
2017
10
Bilateral Sciatic Neuropathy after an Autologous Breast Reconstruction in a Massive Weight Loss Patient. ( 28203505 )
2017
11
Isolated sciatic neuropathy as an initial manifestation of a high grade B-cell lymphoma: A case report and literature review. ( 27540756 )
2016
12
Irreversible electroporation-induced sciatic neuropathy observed by intraoperative neuromonitoring. ( 27417051 )
2016
13
Sciatic neuropathy developed after injection during curettage. ( 27225613 )
2016
14
Preventive Effects of the Chinese Herbal Medicine Prescription Tangkuei Decoction for Frigid Extremities on Sciatic Neuropathy in Streptozotocin-Induced Diabetic Rats. ( 27057201 )
2016
15
Sequential early and delayed painful sciatic neuropathy following revision total hip arthroplasty. ( 26990207 )
2016
16
Sciatic Neuropathy Caused by Focal Venous Engorgement Associated With Deep Vein Thrombosis: A Case Report. ( 26079864 )
2016
17
Early diagnosis of Varicella-zoster virus sciatic neuropathy by MRI neurography. ( 27625277 )
2016
18
Postpartum sciatic neuropathy: Segmental fractional anisotropy analysis to disclose neurapraxia. ( 27572428 )
2016
19
Bilateral sciatic neuropathy misdiagnosed as critical illness neuropathy: a case report. ( 25990100 )
2015
20
Post-injection sciatic neuropathy in a cynomolgus macaque (Macaca fascicularis). ( 24236754 )
2014
21
Hereditary neuropathy with liability to pressure palsies presenting with sciatic neuropathy. ( 25326571 )
2014
22
Bilateral sciatic neuropathy due to fibrous bands in a patient with severe traumatic brain injury. ( 24731584 )
2014
23
Right calf claudication revealing leriche syndrome presenting as right sciatic neuropathy. ( 24639938 )
2014
24
Severe isolated sciatic neuropathy due to a modified lotus position. ( 24579070 )
2014
25
Gluteal Compartment Syndrome Complicated with Bilateral Sciatic Neuropathy. ( 26077186 )
2014
26
Pediatric sciatic neuropathy presenting as painful leg: A case report and review of literature. ( 24082941 )
2013
27
Teaching NeuroImages: sciatic neuropathy after heroin abuse. ( 23960198 )
2013
28
Experimental study of the etiology and pathogenesis of sciatic neuropathy under conditions of therapy for ischium fractures. ( 22803181 )
2012
29
Bilateral sciatic neuropathy in dogs caused by spontaneous muscular and intraneural hemorrhage. ( 22742071 )
2012
30
Sciatic neuropathy after extruded cement from cementoplasty. ( 22698999 )
2012
31
3-T high-resolution MR neurography of sciatic neuropathy. ( 22451573 )
2012
32
Bilateral sciatic neuropathy as a complication of craniotomy performed in the sitting position: localization of nerve injury by using magnetic resonance imaging. ( 21956785 )
2012
33
Minocycline injection in the ventral posterolateral thalamus reverses microglial reactivity and thermal hyperalgesia secondary to sciatic neuropathy. ( 21571034 )
2011
34
Pediatric sciatic neuropathy associated with neoplasms. ( 21254082 )
2011
35
Vascular malformations, rare causes of sciatic neuropathy: a case series. ( 20881578 )
2010
36
A treatment option for post-injection sciatic neuropathy: transsacral block with methylprednisolone. ( 20859314 )
2010
37
Postpartum septic sacroiliitis misdiagnosed as sciatic neuropathy. ( 20090512 )
2010
38
Sciatic neuropathy after body contouring surgery in massive weight loss patients. ( 19703796 )
2010
39
Forceful stretching of the hamstrings at what expense? Sciatic neuropathy in a child. ( 19787185 )
2009
40
Delayed sciatic neuropathy after distal semimembranosus muscle rupture associated with tethering of the sciatic nerve by a rare distal muscular branch. ( 19193374 )
2009
41
Sciatic neuropathy following robot-assisted laparoscopic myomectomy under lithotomy position: A case report. ( 30625841 )
2009
42
Post-radiation sciatic neuropathy: a case report and review of the literature. ( 19077234 )
2008
43
Deep venous thrombosis and inferior vena cava agenesis causing double crush sciatic neuropathy in Behçet's disease. ( 18848486 )
2008
44
Cryoglobulinaemic neuropathy: a further cause of bilateral sciatic neuropathy. ( 18834546 )
2008
45
Governing role of primary afferent drive in increased excitation of spinal nociceptive neurons in a model of sciatic neuropathy. ( 18773893 )
2008
46
Sciatic neuropathy from a giant hibernoma of the thigh: a case report. ( 18587508 )
2008
47
Sciatic neuropathy after lower-extremity trauma: successful treatment of an uncommon pain and disability syndrome in an adolescent. ( 17581294 )
2007
48
Sciatic neuropathy: case report and discussion of the literature on postoperative sciatic neuropathy and sciatic nerve tumors. ( 18751834 )
2006
49
Sciatic neuropathy following endovascular treatment of a limb vascular malformation. ( 17173687 )
2006
50
A case of sciatic neuropathy after caesarean section under spinal anaesthesia. ( 16774831 )
2006

Variations for Sciatic Neuropathy

Expression for Sciatic Neuropathy

Search GEO for disease gene expression data for Sciatic Neuropathy.

Pathways for Sciatic Neuropathy

Pathways related to Sciatic Neuropathy according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.62 IL1B NGF NOTCH1 PDGFB TJP1 TNFRSF1A
2
Show member pathways
12.45 IL1B PDGFB TNFRSF1A TNFRSF1B TNFRSF9
3
Show member pathways
12.45 IL1B NGF PDGFB TNFRSF1A TNFRSF1B
4
Show member pathways
12.41 IL1B NGF TNFRSF1A TNFRSF1B TNFRSF9
5 12.34 IL1B TNFRSF1A TNFRSF1B TNFRSF9
6 12.25 CNR1 DLG4 NGF NOTCH1 SCN10A
7
Show member pathways
11.78 IL1B NGF PDGFB TNFRSF1A TNFRSF1B
8 11.73 IL1B TNFRSF1A TNFRSF1B
9
Show member pathways
11.53 NGF TNFRSF1A TNFRSF1B
10 11.27 IL1B TNFRSF1A TNFRSF1B
11 10.94 NGF TNFRSF1A TNFRSF1B
12 10.82 DLG4 NGF NOTCH1 PDGFB
13 10.81 TNFRSF1A TNFRSF1B TNFRSF9

GO Terms for Sciatic Neuropathy

Cellular components related to Sciatic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.93 CNR1 CNR2 DLG4 NOTCH1 SCN10A SH3TC2
2 axon GO:0030424 9.35 CNR1 DLG4 NGF SCN10A TNFRSF1B
3 tumor necrosis factor receptor superfamily complex GO:0002947 8.62 TNFRSF1A TNFRSF1B

Biological processes related to Sciatic Neuropathy according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.93 CNR1 NGF NOTCH1 TRPV1
2 inflammatory response GO:0006954 9.92 CNR2 IL1B TNFRSF1A TNFRSF1B TRPV1
3 negative regulation of inflammatory response GO:0050728 9.77 CNR2 TNFRSF1A TNFRSF1B
4 tumor necrosis factor-mediated signaling pathway GO:0033209 9.74 TNFRSF1A TNFRSF1B TNFRSF9
5 cellular response to growth factor stimulus GO:0071363 9.72 PDGFB TNFRSF1B TRPV1
6 cardiac muscle tissue morphogenesis GO:0055008 9.62 MYOM2 NOTCH1
7 positive regulation of Ras protein signal transduction GO:0046579 9.62 NGF NOTCH1
8 response to ethanol GO:0045471 9.61 CNR1 TJP1
9 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IL1B TNFRSF1B
10 negative regulation of nitric-oxide synthase activity GO:0051001 9.58 CNR1 CNR2
11 memory GO:0007613 9.58 CNR1 NGF
12 regulation of establishment of endothelial barrier GO:1903140 9.56 IL1B TNFRSF1A
13 sensory perception of pain GO:0019233 9.56 CNR1 CNR2 SCN10A TRPV1
14 negative regulation of mast cell activation GO:0033004 9.51 CNR1 CNR2
15 negative regulation of cardiac muscle hypertrophy GO:0010614 9.5 NOTCH1 TNFRSF1A TNFRSF1B
16 positive regulation of fever generation GO:0031622 9.49 CNR1 IL1B
17 aortic valve development GO:0003176 9.48 TNFRSF1A TNFRSF1B
18 negative regulation of action potential GO:0045759 9.46 CNR1 CNR2
19 cannabinoid signaling pathway GO:0038171 9.43 CNR1 CNR2
20 response to lipopolysaccharide GO:0032496 9.43 CNR1 CNR2 IL1B NOTCH1 TJP1 TNFRSF1B
21 fever generation GO:0001660 9.4 IL1B TRPV1
22 pulmonary valve development GO:0003177 9.37 TNFRSF1A TNFRSF1B
23 negative regulation of extracellular matrix constituent secretion GO:0003332 9.33 NOTCH1 TNFRSF1A TNFRSF1B
24 positive regulation of astrocyte differentiation GO:0048711 9.29 NOTCH1
25 positive regulation of glial cell differentiation GO:0045687 9.24 NOTCH1
26 positive regulation of apoptotic process involved in morphogenesis GO:1902339 8.8 NOTCH1 TNFRSF1A TNFRSF1B

Molecular functions related to Sciatic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 9.16 TNFRSF1A TNFRSF1B
2 cannabinoid receptor activity GO:0004949 8.96 CNR1 CNR2
3 tumor necrosis factor binding GO:0043120 8.62 TNFRSF1A TNFRSF1B

Sources for Sciatic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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