MCID: SCR009
MIFTS: 29

Scirrhous Adenocarcinoma

Categories: Cancer diseases

Aliases & Classifications for Scirrhous Adenocarcinoma

MalaCards integrated aliases for Scirrhous Adenocarcinoma:

Name: Scirrhous Adenocarcinoma 12 15 17
Adenocarcinoma, Scirrhous 44 70
Adenocarcinoma with Productive Fibrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4024
MeSH 44 D002293
NCIt 50 C2928
SNOMED-CT 67 4584002
UMLS 70 C0007135

Summaries for Scirrhous Adenocarcinoma

Disease Ontology : 12 An adenocarcinoma that results in a hard structure owing to the formation of dense connective tissue in the stroma.

MalaCards based summary : Scirrhous Adenocarcinoma, also known as adenocarcinoma, scirrhous, is related to glassy cell carcinoma of the cervix and breast intraductal papillomatosis. An important gene associated with Scirrhous Adenocarcinoma is MVD (Mevalonate Diphosphate Decarboxylase), and among its related pathways/superpathways are Gastric cancer and Signaling by ERBB4. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and thyroid, and related phenotypes are Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection and normal

Related Diseases for Scirrhous Adenocarcinoma

Diseases related to Scirrhous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 glassy cell carcinoma of the cervix 10.0 PGR ERBB2
2 breast intraductal papillomatosis 10.0 PGR ERBB2
3 intraductal papilloma 10.0 PGR ERBB2
4 nipple carcinoma 10.0 PGR ERBB2
5 lipid-rich breast carcinoma 10.0 PGR ERBB2
6 breast scirrhous carcinoma 10.0 PGR ERBB2
7 oncocytic breast carcinoma 10.0 PGR ERBB2
8 apocrine adenosis of breast 10.0 PGR ERBB2
9 breast papillary carcinoma 10.0 PGR ERBB2
10 luminal breast carcinoma b 10.0 PGR ERBB2
11 comedo carcinoma 10.0 PGR ERBB2
12 breast adenoid cystic carcinoma 10.0 PGR ERBB2
13 breast metaplastic carcinoma 10.0 PGR ERBB2
14 breast mucinous carcinoma 10.0 PGR ERBB2
15 lipid-rich carcinoma 10.0 PGR ERBB2
16 breast sarcoma 10.0 PGR ERBB2
17 breast malignant phyllodes tumor 10.0 PGR ERBB2
18 progesterone-receptor negative breast cancer 10.0 PGR ERBB2
19 intracystic papillary adenoma 10.0 PGR ERBB2
20 triple-receptor negative breast cancer 10.0 PGR ERBB2
21 breast osteosarcoma 10.0 PGR ERBB2
22 apocrine sweat gland neoplasm 10.0 PGR ERBB2
23 apocrine adenocarcinoma 10.0 PGR ERBB2
24 breast papillomatosis 10.0 PGR ERBB2
25 intraductal breast benign neoplasm 10.0 PGR ERBB2
26 primary peritoneal carcinoma 10.0 PGR ERBB2
27 synchronous bilateral breast carcinoma 10.0 PGR ERBB2
28 cribriform carcinoma 10.0 PGR ERBB2
29 progesterone-receptor positive breast cancer 10.0 PGR ERBB2
30 endometrial serous adenocarcinoma 10.0 PGR ERBB2
31 hypertrophy of breast 10.0 PGR ERBB2
32 retinitis pigmentosa 47 10.0 PGR ERBB2
33 female reproductive endometrioid cancer 10.0 PGR ERBB2
34 adenosarcoma 10.0 PGR ERBB2
35 mulchandani-bhoj-conlin syndrome 10.0 PGR ERBB2
36 endocervical carcinoma 10.0 PGR ERBB2
37 sweat gland cancer 10.0 PGR ERBB2
38 sweat gland disease 10.0 PGR ERBB2
39 short syndrome 10.0 PGR ERBB2
40 mammary paget's disease 10.0 PGR ERBB2
41 endocervical adenocarcinoma 10.0 PGR ERBB2
42 uterine corpus cancer 10.0 PGR ERBB2
43 liver cirrhosis 10.0
44 pelvic organ prolapse 10.0 PGR COL1A2
45 breast fibroadenoma 9.9 PGR ERBB2
46 estrogen-receptor negative breast cancer 9.9 PGR ERBB2
47 mucinous adenocarcinoma 9.9 PGR ERBB2
48 teeth hard tissue disease 9.9 PGR ERBB2
49 fallopian tube carcinoma 9.9 PGR ERBB2
50 gynecomastia 9.9 PGR ERBB2

Graphical network of the top 20 diseases related to Scirrhous Adenocarcinoma:



Diseases related to Scirrhous Adenocarcinoma

Symptoms & Phenotypes for Scirrhous Adenocarcinoma

GenomeRNAi Phenotypes related to Scirrhous Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection GR00233-A-1 8.32 ERBB2

MGI Mouse Phenotypes related to Scirrhous Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 8.92 CDH1 COL1A2 ERBB2 PGR

Drugs & Therapeutics for Scirrhous Adenocarcinoma

Drugs for Scirrhous Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Single-arm, Multi-center, Phase II Study to Evaluate Efficacy and Safety of Dovitinib (TKI258) in Adult Patients With Advanced Scirrhous Gastric Carcinoma That Have Progressed After One or Two Prior Systemic Treatments Completed NCT01576380 Phase 2 TKI258
2 Evaluation of the HepatoPredict Prognostic Tool in the Decision of Liver Transplant in Hepatocellular Carcinoma Not yet recruiting NCT04499833

Search NIH Clinical Center for Scirrhous Adenocarcinoma

Cochrane evidence based reviews: adenocarcinoma, scirrhous

Genetic Tests for Scirrhous Adenocarcinoma

Anatomical Context for Scirrhous Adenocarcinoma

MalaCards organs/tissues related to Scirrhous Adenocarcinoma:

40
Liver, Pancreas, Thyroid, Lymph Node, Colon, Ovary, Prostate

Publications for Scirrhous Adenocarcinoma

Articles related to Scirrhous Adenocarcinoma:

(show all 29)
# Title Authors PMID Year
1
[A Case of Squamous Cell Carcinoma of the Breast]. 61
28133342 2016
2
[A case of delayed subcutaneous metastases of gastric carcinoma effectively treated with S-1 plus cisplatin chemotherapy]. 61
24394079 2013
3
Metastatic ductal adenocarcinoma in a Western Hognose snake (Heterodon nasicus). 61
20597225 2010
4
The impact of primary tumor size, lymph node status, and other prognostic factors on the risk of cancer death. 61
19658184 2009
5
[Local recurrence of pancreatic cancer successfully treated with gemcitabine]. 61
15751641 2005
6
Clinicopathologic and prognostic characterization of poorly differentiated medullary-type gastric adenocarcinoma. 61
15593457 2004
7
Detection method and breast carcinoma histology. 61
12209738 2002
8
[Pancreatic cancer and mast cells]. 61
12184020 2002
9
Colonic adenocarcinoma in rhesus macaques. 61
11291648 2001
10
Clinical implications of metastases to the ovary. 61
7557597 1995
11
Scirrhous adenocarcinoma of the rectum in a cow. 61
8117809 1993
12
[A resected case of endobronchial metastasis from breast carcinoma]. 61
2214419 1990
13
Multiple primary thyroid and breast cancer in Israel, 1960-1976. 61
2595504 1989
14
Metastatic breast carcinoma of the orbit. 61
2560382 1989
15
Immunohistochemical identification of type I procollagen in tumour cells of scirrhous adenocarcinoma of the stomach. 61
2831927 1988
16
[Lymphography in cancer of the prostate]. 61
2991695 1985
17
[Pathology and histogenesis of gastric scirrhous carcinoma]. 61
6086972 1984
18
[Histological and ultrastructural analysis of infiltrative tumors of the human breast]. 61
6312939 1983
19
[Surgical treatment of breast carcinoma - 30 years' experience]. 61
6283775 1982
20
Primary scirrhous adenocarcinoma of the colon (signet-ring cell type). 61
6274043 1981
21
Gastric neoplasms in the dog: a report of 20 cases. 61
1173578 1975
22
[Scirrhous adenocarcinoma of the pancreas]. 61
4335944 1972
23
[SCIRRHOUS ADENOCARCINOMA OF THE THYROID]. 61
14241270 1964
24
CO-EXISTENT CYSTOSARCOMA PHYLLODES AND SCIRRHOUS ADENOCARCINOMA OF THE BREAST. 61
14080403 1963
25
Scirrhous adenocarcinoma arising in a lipomatous pseudohypertrophic pancreas. 61
14441042 1960
26
CLINICOPATHOLOGIC conference: scirrhous adenocarcinoma of bile duct with metastases and biliary cirrhosis of liver. 61
13078623 1953
27
WEEKLY clinicopathological exercise: scirrhous adenocarcinoma of pancreas with metastases to the liver. 61
14910848 1952
28
WEEKLY clinicopathological exercises: scirrhous adenocarcinoma of pancreas. 61
14882472 1951
29
[Seminar on pathology, clinical medicine and surgical technic; scirrhous adenocarcinoma with normal mucosa]. 61
14809399 1951

Variations for Scirrhous Adenocarcinoma

Expression for Scirrhous Adenocarcinoma

Search GEO for disease gene expression data for Scirrhous Adenocarcinoma.

Pathways for Scirrhous Adenocarcinoma

Pathways related to Scirrhous Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.8 PGR ERBB2 CDH1
2
Show member pathways
11.44 PGR ERBB2
3 11.18 ERBB2 CDH1
4 11.11 ERBB2 CDH1
5 10.94 ERBB2 COL1A2
6 10.45 ERBB2 COL1A2 CDH1
7 10.11 ERBB2 CDH1

GO Terms for Scirrhous Adenocarcinoma

Molecular functions related to Scirrhous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.92 PGR ERBB2 COL1A2 CDH1

Sources for Scirrhous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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