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MCID: SCL013
MIFTS: 29

Scleral Disease

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Scleral Disease

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MalaCards integrated aliases for Scleral Disease:

Name: Scleral Disease 12 15
Scleral Diseases 44 73

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:11343
ICD10 33 H15 H15.9
MeSH 44 D015422
NCIt 50 C79717
SNOMED-CT 68 33064008
UMLS 73 C0036412
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Summaries for Scleral Disease

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MalaCards based summary : Scleral Disease, also known as scleral diseases, is related to arthritis and iritis, and has symptoms including eye manifestations An important gene associated with Scleral Disease is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are NF-kappaB Signaling and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. The drugs beta-endorphin and Hormones have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and lung.

Wikipedia : 76 The sclera,[help 1] also known as the white of the eye, is the opaque, fibrous, protective, outer layer... more...

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Related Diseases for Scleral Disease

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Diseases related to Scleral Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 arthritis 29.5 IL1RN TNF TNFRSF1B
2 iritis 10.2 MRAP TNFRSF1B
3 tenosynovitis 10.2 MRAP TNFRSF1B
4 orbital plasma cell granuloma 10.2 MRAP TNFRSF1B
5 chronic orbital inflammation 10.2 MRAP TNFRSF1B
6 transient arthritis 10.2 MRAP TNFRSF1B
7 chorioretinitis 10.1 MRAP SRCIN1
8 spondyloarthropathy 10.1 MRAP TNF
9 posterior scleritis 10.1 MRAP TNF
10 diffuse infiltrative lymphocytosis syndrome 10.1 MRAP TNF
11 coccidiosis 10.1 MRAP TNF
12 skin sarcoidosis 10.1 TNF TNFRSF1B
13 chronic gonococcal salpingitis 10.1 TNF TNFRSF1B
14 granulomatous dermatitis 10.1 TNF TNFRSF1B
15 inclusion conjunctivitis 10.1 MRAP TNF
16 rheumatoid lung disease 10.1 TNF TNFRSF1B
17 conjunctival disease 10.1 MRAP TNF
18 glaucomatocyclitic crisis 10.1 MRAP TNF
19 chondromalacia 10.1 IL1RN TNFRSF1B
20 peroneal neuropathy 10.1 TNF TNFRSF1B
21 periodic fever, familial, autosomal dominant 10.1 TNF TNFRSF1B
22 post-transplant lymphoproliferative disease 10.1 TNF TNFRSF1B
23 chronic salpingitis 10.1 TNF TNFRSF1B
24 cogan syndrome 10.1 TNF TNFRSF1B
25 melkersson-rosenthal syndrome 10.1 TNF TNFRSF1B
26 systemic onset juvenile idiopathic arthritis 10.1 IL1RN TNF
27 vulvar vestibulitis syndrome 10.1 IL1RN TNF
28 synovitis 10.1 IL1RN TNF
29 osteosclerotic myeloma 10.1 IL1RN TNF
30 aseptic meningitis 10.0 IL1RN TNF
31 joint disorders 10.0 IL1RN TNF
32 guillain-barre syndrome 10.0 TNF TNFRSF1B
33 adult-onset still's disease 10.0 IL1RN TNF
34 parasitic helminthiasis infectious disease 10.0 SRCIN1 TNF
35 dengue shock syndrome 10.0 IL1RN TNF
36 aphthous stomatitis 10.0 IL1RN TNF
37 idiopathic neutropenia 10.0 IL1RN TNF
38 peptic ulcer disease 10.0 IL1RN TNF
39 pericarditis 10.0 IL1RN TNF
40 brucellosis 10.0 IL1RN TNF
41 temporal arteritis 10.0 IL1RN TNF
42 acute salpingitis 10.0 MRAP TNF TNFRSF1B
43 panuveitis 10.0 MRAP TNF TNFRSF1B
44 palindromic rheumatism 10.0 MRAP TNF TNFRSF1B
45 uveal disease 10.0 MRAP TNF TNFRSF1B
46 spondyloarthropathy 1 10.0 MRAP TNF TNFRSF1B
47 silicosis 10.0 IL1RN TNF
48 atrophic gastritis 10.0 IL1RN TNF
49 primary bacterial infectious disease 10.0 TNF TNFRSF1B
50 aggressive periodontitis 10.0 IL1RN TNF

Graphical network of the top 20 diseases related to Scleral Disease:



Diseases related to Scleral Disease
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Symptoms & Phenotypes for Scleral Disease

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UMLS symptoms related to Scleral Disease:


eye manifestations
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Drugs & Therapeutics for Scleral Disease

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Drugs for Scleral Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 beta-endorphin Phase 4,Phase 2
2 Hormones Phase 4,Phase 3,Phase 2,Phase 1
3 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
4 Adrenocorticotropic Hormone Phase 4,Phase 2
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
6 Melanocyte-Stimulating Hormones Phase 4,Phase 2
7
Infliximab Approved Phase 3,Phase 1 170277-31-3
8
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
9
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
10
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
11 Antirheumatic Agents Phase 3,Phase 1,Phase 2
12 Immunologic Factors Phase 3,Phase 1,Phase 2
13 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
14 Antineoplastic Agents, Hormonal Phase 3,Phase 1
15 glucocorticoids Phase 3,Phase 1
16 Anti-Inflammatory Agents Phase 3,Phase 1
17 Gastrointestinal Agents Phase 3,Phase 1
18 Dermatologic Agents Phase 3,Phase 1
19 Antineoplastic Agents, Alkylating Phase 3
20 Alkylating Agents Phase 3
21
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
22
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
23
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 6436030 5284616
24
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
25
Tofacitinib Approved, Investigational Phase 2 477600-75-2
26 Anti-Infective Agents Phase 1, Phase 2
27 Antibiotics, Antitubercular Phase 1, Phase 2
28 Anti-Bacterial Agents Phase 1, Phase 2
29 Antifungal Agents Phase 1, Phase 2
30 Protein Kinase Inhibitors Phase 2
31 Neurotransmitter Agents Phase 2
32 Endorphins Phase 2
33
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
34
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
35 Ophthalmic Solutions Phase 1
36 Peripheral Nervous System Agents Phase 1
37 Dexamethasone 21-phosphate Phase 1
38 HIV Protease Inhibitors Phase 1
39
protease inhibitors Phase 1
40 Autonomic Agents Phase 1
41 Antiemetics Phase 1
42 BB 1101 Phase 1
43 Pharmaceutical Solutions Phase 1
44
Mycophenolic acid Approved 24280-93-1 446541
45
Prednisolone Approved, Vet_approved 50-24-8 5755
46
Azathioprine Approved 446-86-6 2265
47
Etanercept Approved, Investigational 185243-69-0
48
Methylprednisolone Approved, Vet_approved 83-43-2 6741
49
Adalimumab Approved 331731-18-1 16219006
50
Methylprednisolone hemisuccinate Approved 2921-57-5

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
2 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 3 Infliximab;Cyclophosphamide
3 Gevokizumab for Active Scleritis Completed NCT01835132 Phase 1, Phase 2
4 Sirolimus Injections for Autoimmune Scleritis Completed NCT01517074 Phase 1, Phase 2 Sirolimus
5 Rituximab in the Treatment of Scleritis and Non-Infectious Orbital Inflammation Completed NCT00415506 Phase 1, Phase 2 Rituximab
6 Tofacitinib for Inflammatory Eye Disease Recruiting NCT03580343 Phase 2 tofacitinib
7 A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis Not yet recruiting NCT03465111 Phase 2 ACTH (adrenocorticotropic hormone) gel
8 Iontophoresis Delivery of Dexamethasone Phosphate for Non-infectious, Non-necrotizing Anterior Scleritis, Phase 1 Dose-varying Study Completed NCT01059955 Phase 1 Dexamethasone Phosphate Ophthalmic Solution (EGP-437);Dexamethasone phosphate ophthalmic solution
9 Infliximab to Treat Non-Infectious Scleritis Completed NCT00075075 Phase 1 Infliximab
10 Study Evaluating PSI-697 in Patients With Scleritis Terminated NCT00367692 Phase 1 PSI-697
11 Causes of Visual Loss in Retinal Disease Unknown status NCT01613963 Immunosuppressive Agents
12 Perichondrium Autograft in Refractory Necrotizing Scleritis Completed NCT02864823 Not Applicable
13 Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis Completed NCT01958567 Not Applicable
14 Human Samples and Data Repository Completed NCT00539370
15 LSFG-SKIN, Laser Speckle Flowgraphy Completed NCT03660618 Not Applicable
16 Ocular Manifestations in Rheumatic Diseases Active, not recruiting NCT03753893

Search NIH Clinical Center for Scleral Disease

Cochrane evidence based reviews: scleral diseases

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Genetic Tests for Scleral Disease

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Anatomical Context for Scleral Disease

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MalaCards organs/tissues related to Scleral Disease:

41
Eye, Skin, Lung, Bone
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Publications for Scleral Disease

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Articles related to Scleral Disease:

# Title Authors Year
1
Destructive corneal and scleral disease associated with rheumatoid arthritis. Medical and surgical management. ( 7671613 )
1995
2
Ultrasound biomicroscopy in the assessment of anterior scleral disease. ( 8238225 )
1993
3
Progression of scleral disease. ( 2052300 )
1991
4
'Pulsed' immunosuppressive therapy in the treatment of immunologically induced corneal and scleral disease. ( 3443202 )
1987
5
Rheumatic disease in patients suffering from scleral disease. ( 5427425 )
1970
6
Management of scleral disease. ( 5226566 )
1966
7
Slitlamp diagnosis of corneal and scleral disease. ( 13080411 )
1953
8
Some contemporary concepts of scleral disease. ( 14902177 )
1951
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Variations for Scleral Disease

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Expression for Scleral Disease

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Search GEO for disease gene expression data for Scleral Disease.
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Pathways for Scleral Disease

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Pathways related to Scleral Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
11.95 IL1RN TNF TNFRSF1B
2
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 22
Show member pathways
 11.3 TNF TNFRSF1B
3
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.26 IL1RN TNF
4
Adipocytokine signaling pathway 37
11.21 TNF TNFRSF1B
5
Transcription_NF-kB signaling pathway 22
11.05 TNF TNFRSF1B
6
Cellular Transformation by HTLV1 64
Show member pathways
 10.85 TNF TNFRSF1B
7
Interleukin-10 signaling 66
10.49 IL1RN TNF TNFRSF1B
8
14-3-3 and Regulation of BAD Activity 64
10.46 TNF TNFRSF1B
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GO Terms for Scleral Disease

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Biological processes related to Scleral Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.63 IL1RN TNF TNFRSF1B
2 cytokine-mediated signaling pathway GO:0019221 9.5 IL1RN TNF TNFRSF1B
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.49 TNF TNFRSF1B
4 response to glucocorticoid GO:0051384 9.48 IL1RN TNF
5 positive regulation of interleukin-6 production GO:0032755 9.43 IL1RN TNF
6 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.4 TNF TNFRSF1B
7 extrinsic apoptotic signaling pathway GO:0097191 9.37 TNF TNFRSF1B
8 cellular response to lipopolysaccharide GO:0071222 9.33 IL1RN TNF TNFRSF1B
9 positive regulation of JUN kinase activity GO:0043507 9.26 IL1RN TNF
10 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.96 TNF TNFRSF1B
11 chronic inflammatory response to antigenic stimulus GO:0002439 8.62 IL1RN TNF
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Sources for Scleral Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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