Aliases & Classifications for Scleral Disease

MalaCards integrated aliases for Scleral Disease:

Name: Scleral Disease 12 15
Scleral Diseases 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11343
ICD10 33 H15 H15.9
MeSH 44 D015422
NCIt 50 C79717
SNOMED-CT 68 33064008
UMLS 73 C0036412

Summaries for Scleral Disease

MalaCards based summary : Scleral Disease, also known as scleral diseases, is related to chorioretinitis and iritis, and has symptoms including eye manifestations An important gene associated with Scleral Disease is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway and Adipocytokine signaling pathway. The drugs Adrenocorticotropic Hormone and beta-endorphin have been mentioned in the context of this disorder. Affiliated tissues include eye.

Related Diseases for Scleral Disease

Diseases related to Scleral Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 chorioretinitis 10.5 MRAP SRCIN1
2 iritis 10.5 MRAP TNFRSF1B
3 tenosynovitis 10.4 MRAP TNFRSF1B
4 orbital plasma cell granuloma 10.4 MRAP TNFRSF1B
5 chronic orbital inflammation 10.4 MRAP TNFRSF1B
6 posterior scleritis 10.3 MRAP TNF
7 skin sarcoidosis 10.3 TNF TNFRSF1B
8 rheumatoid lung disease 10.3 TNF TNFRSF1B
9 chronic gonococcal salpingitis 10.3 TNF TNFRSF1B
10 peroneal neuropathy 10.2 TNF TNFRSF1B
11 coccidiosis 10.2 MRAP TNF
12 periodic fever, familial, autosomal dominant 10.2 TNF TNFRSF1B
13 sweat gland disease 10.2 TNF TNFRSF1B
14 post-transplant lymphoproliferative disease 10.2 TNF TNFRSF1B
15 chronic salpingitis 10.1 TNF TNFRSF1B
16 exanthem 10.1 TNF TNFRSF1B
17 parasitic helminthiasis infectious disease 10.1 SRCIN1 TNF
18 anterior scleritis 10.1 MRAP SRCIN1 TNFRSF1B
19 cogan syndrome 10.1 TNF TNFRSF1B
20 spondyloarthropathy 10.0 MRAP TNF
21 guillain-barre syndrome 10.0 TNF TNFRSF1B
22 primary bacterial infectious disease 9.9 TNF TNFRSF1B
23 pustulosis of palm and sole 9.9 MRAP TNF TNFRSF1B
24 acute salpingitis 9.9 MRAP TNF TNFRSF1B
25 panuveitis 9.9 MRAP TNF TNFRSF1B
26 palindromic rheumatism 9.9 MRAP TNF TNFRSF1B
27 hypersensitivity reaction type iv disease 9.9 MRAP TNF TNFRSF1B
28 spondyloarthropathy 1 9.9 MRAP TNF TNFRSF1B
29 bone inflammation disease 9.9 MRAP TNF TNFRSF1B
30 intestinal disease 9.9 MRAP TNF TNFRSF1B
31 spondylitis 9.8 TNF TNFRSF1B
32 behcet syndrome 9.8 MRAP TNF TNFRSF1B
33 juvenile rheumatoid arthritis 9.7 TNF TNFRSF1B
34 rheumatoid arthritis 9.6
35 arthritis 9.6
36 rheumatic disease 9.6
37 enthesopathy 9.6
38 sarcoidosis 1 9.5 TNF TNFRSF1B

Graphical network of the top 20 diseases related to Scleral Disease:



Diseases related to Scleral Disease

Symptoms & Phenotypes for Scleral Disease

UMLS symptoms related to Scleral Disease:


eye manifestations

Drugs & Therapeutics for Scleral Disease

Drugs for Scleral Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Adrenocorticotropic Hormone Phase 4
2 beta-endorphin Phase 4
3 Hormone Antagonists Phase 4,Phase 3,Phase 1
4 Hormones Phase 4,Phase 3,Phase 1
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1
6 Melanocyte-Stimulating Hormones Phase 4
7
Infliximab Approved Phase 3,Phase 1 170277-31-3
8
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
9
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
10
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
11 Antirheumatic Agents Phase 3,Phase 1,Phase 2
12 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
13 Anti-Inflammatory Agents Phase 3,Phase 1
14 Antineoplastic Agents, Hormonal Phase 3,Phase 1
15 Dermatologic Agents Phase 3,Phase 1
16 Gastrointestinal Agents Phase 3,Phase 1
17 glucocorticoids Phase 3,Phase 1
18 Alkylating Agents Phase 3
19 Antineoplastic Agents, Alkylating Phase 3
20
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
21
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
22
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
23
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
24 Anti-Bacterial Agents Phase 1, Phase 2
25 Antibiotics, Antitubercular Phase 1, Phase 2
26 Anti-Infective Agents Phase 1, Phase 2
27 Antifungal Agents Phase 1, Phase 2
28
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
29 Antiemetics Phase 1
30 Autonomic Agents Phase 1
31 BB 1101 Phase 1
32 Dexamethasone 21-phosphate Phase 1
33 Dexamethasone acetate Phase 1 1177-87-3
34 HIV Protease Inhibitors Phase 1
35 Ophthalmic Solutions Phase 1
36 Peripheral Nervous System Agents Phase 1
37 Pharmaceutical Solutions Phase 1
38
protease inhibitors Phase 1
39
Adalimumab Approved 331731-18-1 16219006
40
Azathioprine Approved 446-86-6 2265
41
Etanercept Approved, Investigational 185243-69-0
42
Methylprednisolone Approved, Vet_approved 83-43-2 6741
43
Mycophenolate mofetil Approved, Investigational 128794-94-5 5281078
44
Mycophenolic acid Approved 24280-93-1 446541
45
Prednisolone Approved, Vet_approved 50-24-8 5755
46 Antimetabolites
47 Antimetabolites, Antineoplastic
48 Antitubercular Agents
49 Cyclosporins
50 Methylprednisolone acetate

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
2 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 3 Infliximab;Cyclophosphamide
3 Gevokizumab for Active Scleritis Completed NCT01835132 Phase 1, Phase 2
4 Sirolimus Injections for Autoimmune Scleritis Completed NCT01517074 Phase 1, Phase 2 Sirolimus
5 Rituximab in the Treatment of Scleritis and Non-Infectious Orbital Inflammation Completed NCT00415506 Phase 1, Phase 2 Rituximab
6 A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis Not yet recruiting NCT03465111 Phase 2 ACTH (adrenocorticotropic hormone) gel
7 Tofacitinib for Inflammatory Eye Disease Not yet recruiting NCT03580343 Phase 2 tofacitinib
8 Iontophoresis Delivery of Dexamethasone Phosphate for Non-infectious, Non-necrotizing Anterior Scleritis, Phase 1 Dose-varying Study Completed NCT01059955 Phase 1 Dexamethasone Phosphate Ophthalmic Solution (EGP-437);Dexamethasone phosphate ophthalmic solution
9 Infliximab to Treat Non-Infectious Scleritis Completed NCT00075075 Phase 1 Infliximab
10 Study Evaluating PSI-697 in Patients With Scleritis Terminated NCT00367692 Phase 1 PSI-697
11 Causes of Visual Loss in Retinal Disease Unknown status NCT01613963 Immunosuppressive Agents
12 Perichondrium Autograft in Refractory Necrotizing Scleritis Completed NCT02864823 Not Applicable
13 Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis Completed NCT01958567 Not Applicable
14 Human Samples and Data Repository Completed NCT00539370

Search NIH Clinical Center for Scleral Disease

Cochrane evidence based reviews: scleral diseases

Genetic Tests for Scleral Disease

Anatomical Context for Scleral Disease

MalaCards organs/tissues related to Scleral Disease:

41
Eye

Publications for Scleral Disease

Articles related to Scleral Disease:

# Title Authors Year
1
Destructive corneal and scleral disease associated with rheumatoid arthritis. Medical and surgical management. ( 7671613 )
1995
2
Ultrasound biomicroscopy in the assessment of anterior scleral disease. ( 8238225 )
1993
3
Progression of scleral disease. ( 2052300 )
1991
4
'Pulsed' immunosuppressive therapy in the treatment of immunologically induced corneal and scleral disease. ( 3443202 )
1987
5
Rheumatic disease in patients suffering from scleral disease. ( 5427425 )
1970
6
Management of scleral disease. ( 5226566 )
1966
7
Slitlamp diagnosis of corneal and scleral disease. ( 13080411 )
1953
8
Some contemporary concepts of scleral disease. ( 14902177 )
1951

Variations for Scleral Disease

Expression for Scleral Disease

Search GEO for disease gene expression data for Scleral Disease.

Pathways for Scleral Disease

GO Terms for Scleral Disease

Biological processes related to Scleral Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic signaling pathway GO:0097190 9.26 TNF TNFRSF1B
2 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.16 TNF TNFRSF1B
3 extrinsic apoptotic signaling pathway GO:0097191 8.96 TNF TNFRSF1B
4 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.62 TNF TNFRSF1B

Sources for Scleral Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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