Scleral Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Scleral Disease, also known as scleral diseases, is related to scleritis and anterior scleritis, and has symptoms including eye manifestations An important gene associated with Scleral Disease is PRTN3 (Proteinase 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include eye, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

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Related Diseases for Scleral Disease

Diseases in the Scleral Disease family:

Rare Scleral Disorder

Diseases related to Scleral Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 951)

#	Related Disease	Score	Top Affiliating Genes
1	scleritis	29.8	TNF PRTN3 MPO IFNG CRP CCR6
2	anterior scleritis	29.7	TNF PRTN3 IFNG CRP ACE
3	corneal ulcer	29.5	VEGFA TNF IL6 IL1B
4	keratitis, hereditary	28.9	VEGFA TNF IL6 IL1B IL17A CD4
5	posterior scleritis	28.9	VEGFA TNFRSF10A TNF PRTN3 MPO IFNG
6	vasculitis	28.7	TNF PRTN3 MPO IL6 IL1B IL17A
7	rheumatoid arthritis	26.7	VEGFA TNFRSF10A TNF SOCS1 PRTN3 MPO
8	episcleritis periodica fugax	11.0
9	scleromalacia perforans	11.0
10	nodular episcleritis	11.0
11	acquired tear duct stenosis	10.4	PRTN3 MPO
12	stenosis of lacrimal passage	10.4	PRTN3 MPO
13	bicipital tenosynovitis	10.4	PRTN3 CRP
14	allergic cutaneous vasculitis	10.4	PRTN3 MPO
15	mediastinum teratoma	10.4	CRP ACE
16	middle ear cholesterol granuloma	10.4	PRTN3 MPO
17	arteritic anterior ischemic optic neuropathy	10.3	PRTN3 CRP
18	external pathological resorption	10.3	TNF IL6
19	clivus meningioma	10.3	PRTN3 MPO
20	laryngostenosis	10.3	PRTN3 MPO
21	lateral medullary syndrome	10.3	PRTN3 CRP
22	wissler-fanconi syndrome	10.3	PRTN3 CD4
23	ventilation pneumonitis	10.3	CRP CD4
24	syphilitic meningitis	10.3	CRP CD4
25	libman-sacks endocarditis	10.3	PRTN3 CRP
26	brawny scleritis	10.3	IFNG ACE
27	subclavian steal syndrome	10.3	CRP ACE
28	pulmonary aspergilloma	10.3	PRTN3 CRP
29	orbital granuloma	10.3	PRTN3 MPO CRP
30	chronic orbital inflammation	10.3	TNF PRTN3 CRP
31	interstitial keratitis	10.3	TNF PRTN3 CRP
32	ethmoid sinusitis	10.3	PRTN3 MPO CRP
33	acute frontal sinusitis	10.3	PRTN3 MPO CRP
34	cogan syndrome	10.3	TNF PRTN3 CRP
35	erythema elevatum diutinum	10.3	PRTN3 MPO CRP
36	pulmonary hemosiderosis	10.3	PRTN3 MPO CRP
37	enterocolitis	10.3	TNF IL6 CRP
38	subacute bacterial endocarditis	10.3	PRTN3 MPO CRP
39	toxic megacolon	10.3	TNF CRP CCR6
40	angelucci's syndrome	10.3	IL17A IFNG
41	silent myocardial infarction	10.3	CRP ACE
42	splenic infarction	10.3	PRTN3 MPO CRP
43	cholesterol embolism	10.3	PRTN3 CRP ACE
44	tolosa-hunt syndrome	10.3	PRTN3 CRP ACE
45	type 1 diabetes mellitus 23	10.3	TNF CD4
46	maxillary sinusitis	10.3	PRTN3 MPO CRP
47	intracranial abscess	10.3	CRP CD4
48	melkersson-rosenthal syndrome	10.3	TNF CRP ACE
49	pyuria	10.3	PRTN3 IL6 CRP
50	chromium allergic contact dermatitis	10.3	IL2 IL17A

Graphical network of the top 20 diseases related to Scleral Disease:

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Symptoms & Phenotypes for Scleral Disease

UMLS symptoms related to Scleral Disease:

eye manifestations

GenomeRNAi Phenotypes related to Scleral Disease according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.36	IL17A IL1B MPO TNF TNFRSF10A
2	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.36	ACE IL17A IL1B IL2 MPO TNF

MGI Mouse Phenotypes related to Scleral Disease:

⁴⁵ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.33	ACE CCR6 CD4 CRP IFNG IL17A
2	immune system	MP:0005387	10.22	ACE CCR6 CD4 CRP IFNG IL17A
3	endocrine/exocrine gland	MP:0005379	10.17	ACE CD4 IFNG IL17A IL2 IL6
4	neoplasm	MP:0002006	10.16	ACE IFNG IL1B IL2 IL6 SOCS1
5	cardiovascular system	MP:0005385	10.15	ACE CCR6 CRP IFNG IL1B IL2
6	liver/biliary system	MP:0005370	10.13	ACE IFNG IL17A IL2 IL6 JAK1
7	no phenotypic analysis	MP:0003012	10.1	CD4 IFNG IL17A IL2 PRTN3 TNF
8	hematopoietic system	MP:0005397	10.03	ACE CCR6 CD4 IFNG IL17A IL1B
9	digestive/alimentary	MP:0005381	10.01	CD4 IFNG IL17A IL2 IL6 SOCS1
10	respiratory system	MP:0005388	9.86	IFNG IL17A IL2 IL6 JAK1 SOCS1
11	mortality/aging	MP:0010768	9.77	ACE CD4 IFNG IL17A IL1B IL2
12	integument	MP:0010771	9.28	CD4 IFNG IL17A IL1B IL6 JAK1

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Drugs & Therapeutics for Scleral Disease

Search Clinical Trials, NIH Clinical Center for Scleral Disease

Cochrane evidence based reviews: scleral diseases

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Genetic Tests for Scleral Disease

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Anatomical Context for Scleral Disease

Organs/tissues related to Scleral Disease:

MalaCards : Eye

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Publications for Scleral Disease

Articles related to Scleral Disease:

(show all 22)

#	Title	Authors	PMID	Year
1	Semilunar sign of cornea: A multimodal analysis of the posterior corneal opacity in non-infectious anterior scleritis. ⁶²	Kumar DA...Chinnappan RM	35326015	2022
2	Enteric-coated mycophenolate sodium as a corticosteroid-sparing agent for the treatment of autoimmune scleritis. ⁶²	Hwang YS...Hsiao CH	21099416	2011
3	Retinoblastoma patients with high risk ocular pathological features: who needs adjuvant therapy? ⁶²	Chantada GL...Abramson DH	15258027	2004
4	Scleral nodule associated with sarcoidosis. ⁶²	Qazi FA...Jabs DA	14516826	2003
5	Ultrasound biomicroscopy in scleritis. ⁶²	Heiligenhaus A...Steuhl KP	9499786	1998
6	Successful management of Aspergillus scleritis by medical and surgical treatment. ⁶²	Bernauer W...Dart JK	9683961	1998
7	Destructive corneal and scleral disease associated with rheumatoid arthritis. Medical and surgical management. ⁶²	Messmer EM...Foster CS	7671613	1995
8	Ultrasound biomicroscopy in the assessment of anterior scleral disease. ⁶²	Pavlin CJ...Foster FS	8238225	1993
9	Progression of scleral disease. ⁶²	Tuft SJ...Watson PG	2052300	1991
10	Current concepts in the management of scleritis. ⁶²	McCluskey P...Wakefield D	3052526	1988
11	Anterior segment fluorescein angiography in the surgery of immunologically induced corneal and scleral destructive disorders. ⁶²	Watson PG	3317186	1987
12	'Pulsed' immunosuppressive therapy in the treatment of immunologically induced corneal and scleral disease. ⁶²	Meyer PA...Dubord P	3443202	1987
13	Changes at the periphery of a lesion in necrotising scleritis: anterior segment fluorescein angiography correlated with electron microscopy. ⁶²	Watson PG...Young RD	4041412	1985
14	Microscopical studies of necrotising scleritis. I. Cellular aspects. ⁶²	Young RD...Watson PG	6498132	1984
15	Ultrastructural studies of corneal collagen during the development of experimental scleritis in rabbits. ⁶²	Young RD...Dingle JT	6455278	1981
16	Destructive corneal disease in the connective tissue disorders. Comparison with an experimental animal model. ⁶²	Lloyd-Jones D...Hembry RM	38536	1978
17	Senile scleral plaques and senile scleromalacia. ⁶²	Manschot WA	666986	1978
18	Scleritis and associated disease. ⁶²	Lachmann SM...Watson PG	620214	1978
19	Rheumatic disease in patients suffering from scleral disease. ⁶²	Fowler P	5427425	1970
20	Management of scleral disease. ⁶²	Watson PG	5226566	1966
21	Slitlamp diagnosis of corneal and scleral disease. ⁶²	BERLINER ML	13080411	1953
22	Some contemporary concepts of scleral disease. ⁶²	SWAN KC	14902177	1951

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Genes for Scleral Disease

Genes related to Scleral Disease (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PRTN3	Proteinase 3	Protein Coding	7.32	DISEASES inferred ¹⁴
2	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	7.14	DISEASES inferred ¹⁴ ¹⁴
3	CRP	C-Reactive Protein	Protein Coding	6.49	DISEASES inferred ¹⁴
4	TNF	Tumor Necrosis Factor	Protein Coding	6.43	DISEASES inferred ¹⁴
5	MPO	Myeloperoxidase	Protein Coding	6.04	DISEASES inferred ¹⁴
6	ACE	Angiotensin I Converting Enzyme	Protein Coding	5.86	DISEASES inferred ¹⁴
7	IL17A	Interleukin 17A	Protein Coding	5.81	DISEASES inferred ¹⁴
8	IL6	Interleukin 6	Protein Coding	5.78	DISEASES inferred ¹⁴
9	CD4	CD4 Molecule	Protein Coding	5.74	DISEASES inferred ¹⁴
10	IL2	Interleukin 2	Protein Coding	5.63	DISEASES inferred ¹⁴
11	IFNG	Interferon Gamma	Protein Coding	5.48	DISEASES inferred ¹⁴
12	RBP3	Retinol Binding Protein 3	Protein Coding	5.46	DISEASES inferred ¹⁴
13	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	5.38	DISEASES inferred ¹⁴
14	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	5.22	DISEASES inferred ¹⁴
15	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	5.17	DISEASES inferred ¹⁴
16	IL1B	Interleukin 1 Beta	Protein Coding	5.03	DISEASES inferred ¹⁴
17	JAK1	Janus Kinase 1	Protein Coding	4.98	DISEASES inferred ¹⁴
18	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	4.95	DISEASES inferred ¹⁴

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Variations for Scleral Disease

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Expression for Scleral Disease

Search GEO for disease gene expression data for Scleral Disease.

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Pathways for Scleral Disease

Pathways related to Scleral Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 77)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.98	VEGFA TNF SOCS1 PRTN3 MPO JAK1
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.87	CCR6 CD4 IL17A IL1B IL2 IL6
3	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.67	CCR6 CD4 IFNG IL17A IL1B IL2
4	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.6	VEGFA TNFRSF10A TNF SOCS1 JAK1 IL6
5	Prolactin Signaling ⁶⁴ Show member pathways Development Prolactin receptor signaling ²² EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ⁷⁴ ErbB Family Pathway ⁶⁴ ErbB signaling pathway ⁷⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Estrogen-stimulated signaling through PRKCZ ⁶⁶ Glioblastoma Multiforme ⁶⁴ Glioblastoma signaling pathways ⁷⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-2 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TCA cycle nutrient use and invasiveness of ovarian cancer ⁷⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVA-Induced MAPK Signaling ⁶⁴ UVB-Induced MAPK Signaling ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.51	VEGFA TNF SOCS1 JAK1 IL6 IL2
6	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.47	TNFRSF10A TNF JAK1 IL6 IL2 IL1B
7	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.36	TNFRSF10A TNF IL6 IL2 IL1B IL17A
8	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.32	VEGFA TNF SOCS1 PRTN3 JAK1 IL6
9	IL-9 Signaling Pathways ⁶⁵ Show member pathways Adipocytokines and Insulin Signaling ⁶⁵ Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁵ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁵ IL-2 Signaling Pathways ⁶⁵ IL-21 Signaling Pathways ⁶⁵ IL-4 Pathway ⁶⁴ IL-4 Signaling Pathways ⁶⁵ IL-7 Signaling Pathways ⁶⁵ IL-9 Pathway ⁶⁴ Immune response IL-9 signaling pathway ²² Interleukin-9 signaling ⁶⁶	12.93	TNF SOCS1 JAK1 IL6 IL2 HLA-DRB1
10	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.91	IL1B IL2 IL6 JAK1 SOCS1 TNF
11	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.73	TNFRSF10A TNF SOCS1 JAK1 IL6 IL2
12	NF-kappaB Signaling ³	12.65	IFNG IL17A IL1B IL2 JAK1 MPO
13	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.59	CD4 IFNG IL17A IL1B IL2 IL6
14	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.49	TNF JAK1 IL6 IL1B IFNG
15	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.39	TNF JAK1 IL6 IL1B IFNG
16	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ⁶⁷ IL-17 signaling pathway ⁷⁴ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.32	TNF JAK1 IL6 IL17A
17	Colorectal Cancer Metastasis ⁶⁴	12.29	VEGFA TNF JAK1 IL6 IFNG
18	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.26	CD4 HLA-DRB1 IFNG IL17A IL2 TNF
19	Immune response Antigen presentation by MHC class II ²² Show member pathways G-protein signaling N-RAS regulation pathway ²² IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²²	12.25	JAK1 IL2 HLA-DRB1 CD4
20	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.22	VEGFA TNF IL6 IL1B
21	Neuroinflammation and glutamatergic signaling ⁷⁴	12.21	IFNG IL1B IL6 JAK1 TNF
22	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	12.13	TNF MPO IL6 IL2 IFNG CD4
23	IL2 signaling events mediated by STAT5 ⁶¹ Show member pathways IL2 signaling events mediated by PI3K ⁶¹ IL2-mediated signaling events ⁶¹ Interleukin-2 signaling ⁶⁶	12.1	SOCS1 JAK1 IL2 IFNG
24	Spinal cord injury ⁷⁴	12.1	IFNG IL1B IL2 IL6 TNF
25	IL12-mediated signaling events ⁶¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	12.08	SOCS1 IL2 IL1B IFNG CD4
26	Interleukin-4 and Interleukin-13 signaling ⁶⁶	12.01	VEGFA TNF SOCS1 JAK1 IL6 IL1B
27	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	12	CD4 IFNG IL17A IL1B IL6 JAK1
28	CCL18 signaling pathway ⁷⁴	11.91	VEGFA IL6 CCR6
29	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	11.89	JAK1 IL6 IL17A
30	Interferon Pathway ⁶⁴	11.88	JAK1 IL6 IFNG
31	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.88	IL6 HLA-DRB1 CRP CD4
32	Allograft rejection ⁷⁴	11.88	VEGFA TNF IL2 IL1B IL17A IFNG
33	Burn wound healing ⁷⁴	11.86	VEGFA TNF IL6 IL1B
34	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.86	TNF IL6 IL2 IFNG CRP
35	Acute viral myocarditis ⁷⁴	11.86	SOCS1 JAK1 IL6 IL2 IFNG CD4
36	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.84	TNF IL6 IL2 IL1B IFNG CD4
37	Activation of NF-KappaB by PKR ⁶⁴ Show member pathways Canonical NF-kB pathway ⁷⁴ Cellular Transformation by HTLV1 ⁶⁴ Inhibition of PKR ⁶⁶ STING pathway in Kawasaki-like disease and COVID-19 ⁷⁴	11.82	IFNG IL1B TNF
38	C-MYB transcription factor network ⁶¹	11.82	CD4 MPO PRTN3
39	Glucocorticoid receptor regulatory network ⁶¹	11.8	IL6 IL2 IFNG
40	IL 10 signaling pathway ⁶⁷	11.8	TNF SOCS1 JAK1 IL6 IL1B
41	Interleukin-6 family signaling ⁶⁶ Show member pathways IL-6-type cytokine receptor ligand interactions ⁶⁶ Immune response Oncostatin M signaling via JAK-Stat in human cells ²² Interleukin-6 signaling ⁶⁶	11.77	VEGFA JAK1 IL6
42	Innate Lymphoid Cells Differentiation ⁶⁵	11.77	TNF IL2 IL1B IL17A IFNG CD4
43	AP-1 transcription factor network ⁶¹	11.75	IL6 IL2 IFNG
44	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.75	TNF IL6 IL2 IFNG
45	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.75	IFNG IL1B IL2 IL6 TNF VEGFA
46	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ⁶¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ⁶¹	11.74	TNF IL2 IFNG
47	SHP2 signaling ⁶¹	11.72	VEGFA JAK1 IL6 IL2 IFNG
48	Lung fibrosis ⁷⁴	11.71	TNF IL6 IL1B
49	Hepatitis C and hepatocellular carcinoma ⁷⁴	11.65	IL6 JAK1 VEGFA
50	THC Differentiation Pathway ⁶⁴	11.65	TNF IL2 IFNG HLA-DRB1 CD4

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GO Terms for Scleral Disease

Cellular components related to Scleral Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.03	ACE CRP IFNG IL17A IL1B IL2
2	external side of plasma membrane	GO:0009897	9.93	TNF IL17A HLA-DRB1 CD4 CCR6 ACE
3	extracellular space	GO:0005615	9.74	VEGFA TNF RBP3 PRTN3 MPO IL6

Biological processes related to Scleral Disease according to GeneCards Suite gene sharing:

(show all 35)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell population proliferation	GO:0008284	10.44	VEGFA PRTN3 IL6 IL2 IL1B IFNG
2	positive regulation of gene expression	GO:0010628	10.43	CRP IFNG IL1B IL6 TNF VEGFA
3	defense response to Gram-positive bacterium	GO:0050830	10.24	TNF IL6 IL1B IL17A CRP
4	positive regulation of MAPK cascade	GO:0043410	10.23	VEGFA TNF IL6 HLA-DRB1 CD4
5	response to lipopolysaccharide	GO:0032496	10.21	TNF MPO IL1B ACE
6	positive regulation of protein phosphorylation	GO:0001934	10.2	VEGFA TNF IL2 IL1B HLA-DRB1 CD4
7	positive regulation of interleukin-1 beta production	GO:0032731	10.16	TNF IL6 IL17A IFNG
8	positive regulation of phagocytosis	GO:0050766	10.14	TNF IL1B IFNG
9	receptor signaling pathway via JAK-STAT	GO:0007259	10.13	IFNG JAK1 SOCS1
10	regulation of insulin secretion	GO:0050796	10.13	TNF IL6 IL1B IFNG
11	positive regulation of inflammatory response	GO:0050729	10.13	TNF IL2 IL1B IFNG ACE
12	positive regulation of nitric oxide biosynthetic process	GO:0045429	10.12	TNF IL1B IFNG
13	positive regulation of cytokine production involved in inflammatory response	GO:1900017	10.1	TNF IL6 IL17A
14	positive regulation of interleukin-6 production	GO:0032755	10.1	IFNG IL17A IL1B IL6 TNF
15	negative regulation of neurogenesis	GO:0050768	10.09	TNF IL6 IL1B
16	positive regulation of osteoclast differentiation	GO:0045672	10.09	TNF IL17A IFNG
17	positive regulation of glial cell proliferation	GO:0060252	10.06	IL1B IL6 TNF
18	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	10.04	TNF IL1B IFNG
19	positive regulation of chemokine production	GO:0032722	10.04	IFNG IL1B IL6 TNF
20	astrocyte activation	GO:0048143	10.02	IFNG IL1B TNF
21	positive regulation of neuroinflammatory response	GO:0150078	9.99	TNF IL6 IL1B
22	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.97	VEGFA TNF IL6 IL2 IFNG
23	humoral immune response	GO:0006959	9.96	TNF IL6 IFNG HLA-DRB1 CCR6
24	negative regulation of lipid storage	GO:0010888	9.95	TNF IL6 CRP
25	positive regulation of fever generation	GO:0031622	9.94	TNF IL1B
26	sequestering of triglyceride	GO:0030730	9.94	TNF IL1B
27	positive regulation of peptidyl-tyrosine autophosphorylation	GO:1900086	9.93	VEGFA ACE
28	positive regulation of nitrogen compound metabolic process	GO:0051173	9.93	IFNG TNF
29	response to gold nanoparticle	GO:1990268	9.91	TNF MPO
30	negative regulation of gap junction assembly	GO:1903597	9.9	IL1B ACE
31	positive regulation of vitamin D biosynthetic process	GO:0060557	9.89	TNF IFNG
32	vascular endothelial growth factor production	GO:0010573	9.85	TNF IL6 IL1B
33	immune response	GO:0006955	9.83	TNF IL6 IL2 IL1B IL17A IFNG
34	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.63	IFNG IL1B TNF
35	macrophage differentiation	GO:0030225	9.32	VEGFA SOCS1 IFNG HLA-DRB1 CD4

Molecular functions related to Scleral Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.47	VEGFA TNF IL6 IL2 IL1B IL17A

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⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: SCL013 MIFTS: 37	Scleral Disease Categories: Eye diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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