MCID: SCL013
MIFTS: 37

Scleral Disease

Categories: Eye diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Scleral Disease

MalaCards integrated aliases for Scleral Disease:

Name: Scleral Disease 11 14
Scleral Diseases 43 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:11343
MeSH 43 D015422
NCIt 49 C79717
SNOMED-CT 68 33064008
ICD10 31 H15
UMLS 71 C0036412

Summaries for Scleral Disease

Disease Ontology: 11 An eye disease that affects the sclera, which is the white fibrous outer layer of the eyeball.

MalaCards based summary: Scleral Disease, also known as scleral diseases, is related to scleritis and anterior scleritis, and has symptoms including eye manifestations An important gene associated with Scleral Disease is PRTN3 (Proteinase 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include eye, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Related Diseases for Scleral Disease

Diseases in the Scleral Disease family:

Rare Scleral Disorder

Diseases related to Scleral Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 951)
# Related Disease Score Top Affiliating Genes
1 scleritis 29.8 TNF PRTN3 MPO IFNG CRP CCR6
2 anterior scleritis 29.7 TNF PRTN3 IFNG CRP ACE
3 corneal ulcer 29.5 VEGFA TNF IL6 IL1B
4 keratitis, hereditary 28.9 VEGFA TNF IL6 IL1B IL17A CD4
5 posterior scleritis 28.9 VEGFA TNFRSF10A TNF PRTN3 MPO IFNG
6 vasculitis 28.7 TNF PRTN3 MPO IL6 IL1B IL17A
7 rheumatoid arthritis 26.7 VEGFA TNFRSF10A TNF SOCS1 PRTN3 MPO
8 episcleritis periodica fugax 11.0
9 scleromalacia perforans 11.0
10 nodular episcleritis 11.0
11 acquired tear duct stenosis 10.4 PRTN3 MPO
12 stenosis of lacrimal passage 10.4 PRTN3 MPO
13 bicipital tenosynovitis 10.4 PRTN3 CRP
14 allergic cutaneous vasculitis 10.4 PRTN3 MPO
15 mediastinum teratoma 10.4 CRP ACE
16 middle ear cholesterol granuloma 10.4 PRTN3 MPO
17 arteritic anterior ischemic optic neuropathy 10.3 PRTN3 CRP
18 external pathological resorption 10.3 TNF IL6
19 clivus meningioma 10.3 PRTN3 MPO
20 laryngostenosis 10.3 PRTN3 MPO
21 lateral medullary syndrome 10.3 PRTN3 CRP
22 wissler-fanconi syndrome 10.3 PRTN3 CD4
23 ventilation pneumonitis 10.3 CRP CD4
24 syphilitic meningitis 10.3 CRP CD4
25 libman-sacks endocarditis 10.3 PRTN3 CRP
26 brawny scleritis 10.3 IFNG ACE
27 subclavian steal syndrome 10.3 CRP ACE
28 pulmonary aspergilloma 10.3 PRTN3 CRP
29 orbital granuloma 10.3 PRTN3 MPO CRP
30 chronic orbital inflammation 10.3 TNF PRTN3 CRP
31 interstitial keratitis 10.3 TNF PRTN3 CRP
32 ethmoid sinusitis 10.3 PRTN3 MPO CRP
33 acute frontal sinusitis 10.3 PRTN3 MPO CRP
34 cogan syndrome 10.3 TNF PRTN3 CRP
35 erythema elevatum diutinum 10.3 PRTN3 MPO CRP
36 pulmonary hemosiderosis 10.3 PRTN3 MPO CRP
37 enterocolitis 10.3 TNF IL6 CRP
38 subacute bacterial endocarditis 10.3 PRTN3 MPO CRP
39 toxic megacolon 10.3 TNF CRP CCR6
40 angelucci's syndrome 10.3 IL17A IFNG
41 silent myocardial infarction 10.3 CRP ACE
42 splenic infarction 10.3 PRTN3 MPO CRP
43 cholesterol embolism 10.3 PRTN3 CRP ACE
44 tolosa-hunt syndrome 10.3 PRTN3 CRP ACE
45 type 1 diabetes mellitus 23 10.3 TNF CD4
46 maxillary sinusitis 10.3 PRTN3 MPO CRP
47 intracranial abscess 10.3 CRP CD4
48 melkersson-rosenthal syndrome 10.3 TNF CRP ACE
49 pyuria 10.3 PRTN3 IL6 CRP
50 chromium allergic contact dermatitis 10.3 IL2 IL17A

Graphical network of the top 20 diseases related to Scleral Disease:



Diseases related to Scleral Disease

Symptoms & Phenotypes for Scleral Disease

UMLS symptoms related to Scleral Disease:


eye manifestations

GenomeRNAi Phenotypes related to Scleral Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.36 IL17A IL1B MPO TNF TNFRSF10A
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.36 ACE IL17A IL1B IL2 MPO TNF

MGI Mouse Phenotypes related to Scleral Disease:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.33 ACE CCR6 CD4 CRP IFNG IL17A
2 immune system MP:0005387 10.22 ACE CCR6 CD4 CRP IFNG IL17A
3 endocrine/exocrine gland MP:0005379 10.17 ACE CD4 IFNG IL17A IL2 IL6
4 neoplasm MP:0002006 10.16 ACE IFNG IL1B IL2 IL6 SOCS1
5 cardiovascular system MP:0005385 10.15 ACE CCR6 CRP IFNG IL1B IL2
6 liver/biliary system MP:0005370 10.13 ACE IFNG IL17A IL2 IL6 JAK1
7 no phenotypic analysis MP:0003012 10.1 CD4 IFNG IL17A IL2 PRTN3 TNF
8 hematopoietic system MP:0005397 10.03 ACE CCR6 CD4 IFNG IL17A IL1B
9 digestive/alimentary MP:0005381 10.01 CD4 IFNG IL17A IL2 IL6 SOCS1
10 respiratory system MP:0005388 9.86 IFNG IL17A IL2 IL6 JAK1 SOCS1
11 mortality/aging MP:0010768 9.77 ACE CD4 IFNG IL17A IL1B IL2
12 integument MP:0010771 9.28 CD4 IFNG IL17A IL1B IL6 JAK1

Drugs & Therapeutics for Scleral Disease

Search Clinical Trials, NIH Clinical Center for Scleral Disease

Cochrane evidence based reviews: scleral diseases

Genetic Tests for Scleral Disease

Anatomical Context for Scleral Disease

Organs/tissues related to Scleral Disease:

MalaCards : Eye

Publications for Scleral Disease

Articles related to Scleral Disease:

(show all 22)
# Title Authors PMID Year
1
Semilunar sign of cornea: A multimodal analysis of the posterior corneal opacity in non-infectious anterior scleritis. 62
35326015 2022
2
Enteric-coated mycophenolate sodium as a corticosteroid-sparing agent for the treatment of autoimmune scleritis. 62
21099416 2011
3
Retinoblastoma patients with high risk ocular pathological features: who needs adjuvant therapy? 62
15258027 2004
4
Scleral nodule associated with sarcoidosis. 62
14516826 2003
5
Ultrasound biomicroscopy in scleritis. 62
9499786 1998
6
Successful management of Aspergillus scleritis by medical and surgical treatment. 62
9683961 1998
7
Destructive corneal and scleral disease associated with rheumatoid arthritis. Medical and surgical management. 62
7671613 1995
8
Ultrasound biomicroscopy in the assessment of anterior scleral disease. 62
8238225 1993
9
Progression of scleral disease. 62
2052300 1991
10
Current concepts in the management of scleritis. 62
3052526 1988
11
Anterior segment fluorescein angiography in the surgery of immunologically induced corneal and scleral destructive disorders. 62
3317186 1987
12
'Pulsed' immunosuppressive therapy in the treatment of immunologically induced corneal and scleral disease. 62
3443202 1987
13
Changes at the periphery of a lesion in necrotising scleritis: anterior segment fluorescein angiography correlated with electron microscopy. 62
4041412 1985
14
Microscopical studies of necrotising scleritis. I. Cellular aspects. 62
6498132 1984
15
Ultrastructural studies of corneal collagen during the development of experimental scleritis in rabbits. 62
6455278 1981
16
Destructive corneal disease in the connective tissue disorders. Comparison with an experimental animal model. 62
38536 1978
17
Senile scleral plaques and senile scleromalacia. 62
666986 1978
18
Scleritis and associated disease. 62
620214 1978
19
Rheumatic disease in patients suffering from scleral disease. 62
5427425 1970
20
Management of scleral disease. 62
5226566 1966
21
Slitlamp diagnosis of corneal and scleral disease. 62
13080411 1953
22
Some contemporary concepts of scleral disease. 62
14902177 1951

Variations for Scleral Disease

Expression for Scleral Disease

Search GEO for disease gene expression data for Scleral Disease.

Pathways for Scleral Disease

Pathways related to Scleral Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 VEGFA TNF SOCS1 PRTN3 MPO JAK1
2
Show member pathways
13.87 CCR6 CD4 IL17A IL1B IL2 IL6
3
Show member pathways
13.67 CCR6 CD4 IFNG IL17A IL1B IL2
4
Show member pathways
13.6 VEGFA TNFRSF10A TNF SOCS1 JAK1 IL6
5
Show member pathways
13.51 VEGFA TNF SOCS1 JAK1 IL6 IL2
6
Show member pathways
13.47 TNFRSF10A TNF JAK1 IL6 IL2 IL1B
7
Show member pathways
13.36 TNFRSF10A TNF IL6 IL2 IL1B IL17A
8
Show member pathways
13.32 VEGFA TNF SOCS1 PRTN3 JAK1 IL6
9
Show member pathways
12.93 TNF SOCS1 JAK1 IL6 IL2 HLA-DRB1
10
Show member pathways
12.91 IL1B IL2 IL6 JAK1 SOCS1 TNF
11
Show member pathways
12.73 TNFRSF10A TNF SOCS1 JAK1 IL6 IL2
12 12.65 IFNG IL17A IL1B IL2 JAK1 MPO
13
Show member pathways
12.59 CD4 IFNG IL17A IL1B IL2 IL6
14
Show member pathways
12.49 TNF JAK1 IL6 IL1B IFNG
15
Show member pathways
12.39 TNF JAK1 IL6 IL1B IFNG
16
Show member pathways
12.32 TNF JAK1 IL6 IL17A
17 12.29 VEGFA TNF JAK1 IL6 IFNG
18
Show member pathways
12.26 CD4 HLA-DRB1 IFNG IL17A IL2 TNF
19
Show member pathways
12.25 JAK1 IL2 HLA-DRB1 CD4
20 12.22 VEGFA TNF IL6 IL1B
21 12.21 IFNG IL1B IL6 JAK1 TNF
22 12.13 TNF MPO IL6 IL2 IFNG CD4
23
Show member pathways
12.1 SOCS1 JAK1 IL2 IFNG
24 12.1 IFNG IL1B IL2 IL6 TNF
25
Show member pathways
12.08 SOCS1 IL2 IL1B IFNG CD4
26 12.01 VEGFA TNF SOCS1 JAK1 IL6 IL1B
27
Show member pathways
12 CD4 IFNG IL17A IL1B IL6 JAK1
28 11.91 VEGFA IL6 CCR6
29
Show member pathways
11.89 JAK1 IL6 IL17A
30 11.88 JAK1 IL6 IFNG
31
Show member pathways
11.88 IL6 HLA-DRB1 CRP CD4
32 11.88 VEGFA TNF IL2 IL1B IL17A IFNG
33 11.86 VEGFA TNF IL6 IL1B
34 11.86 TNF IL6 IL2 IFNG CRP
35 11.86 SOCS1 JAK1 IL6 IL2 IFNG CD4
36 11.84 TNF IL6 IL2 IL1B IFNG CD4
37
Show member pathways
11.82 IFNG IL1B TNF
38 11.82 CD4 MPO PRTN3
39 11.8 IL6 IL2 IFNG
40 11.8 TNF SOCS1 JAK1 IL6 IL1B
41
Show member pathways
11.77 VEGFA JAK1 IL6
42 11.77 TNF IL2 IL1B IL17A IFNG CD4
43 11.75 IL6 IL2 IFNG
44
Show member pathways
11.75 TNF IL6 IL2 IFNG
45
Show member pathways
11.75 IFNG IL1B IL2 IL6 TNF VEGFA
46
Show member pathways
11.74 TNF IL2 IFNG
47 11.72 VEGFA JAK1 IL6 IL2 IFNG
48 11.71 TNF IL6 IL1B
49 11.65 IL6 JAK1 VEGFA
50 11.65 TNF IL2 IFNG HLA-DRB1 CD4

GO Terms for Scleral Disease

Cellular components related to Scleral Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.03 ACE CRP IFNG IL17A IL1B IL2
2 external side of plasma membrane GO:0009897 9.93 TNF IL17A HLA-DRB1 CD4 CCR6 ACE
3 extracellular space GO:0005615 9.74 VEGFA TNF RBP3 PRTN3 MPO IL6

Biological processes related to Scleral Disease according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell population proliferation GO:0008284 10.44 VEGFA PRTN3 IL6 IL2 IL1B IFNG
2 positive regulation of gene expression GO:0010628 10.43 CRP IFNG IL1B IL6 TNF VEGFA
3 defense response to Gram-positive bacterium GO:0050830 10.24 TNF IL6 IL1B IL17A CRP
4 positive regulation of MAPK cascade GO:0043410 10.23 VEGFA TNF IL6 HLA-DRB1 CD4
5 response to lipopolysaccharide GO:0032496 10.21 TNF MPO IL1B ACE
6 positive regulation of protein phosphorylation GO:0001934 10.2 VEGFA TNF IL2 IL1B HLA-DRB1 CD4
7 positive regulation of interleukin-1 beta production GO:0032731 10.16 TNF IL6 IL17A IFNG
8 positive regulation of phagocytosis GO:0050766 10.14 TNF IL1B IFNG
9 receptor signaling pathway via JAK-STAT GO:0007259 10.13 IFNG JAK1 SOCS1
10 regulation of insulin secretion GO:0050796 10.13 TNF IL6 IL1B IFNG
11 positive regulation of inflammatory response GO:0050729 10.13 TNF IL2 IL1B IFNG ACE
12 positive regulation of nitric oxide biosynthetic process GO:0045429 10.12 TNF IL1B IFNG
13 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.1 TNF IL6 IL17A
14 positive regulation of interleukin-6 production GO:0032755 10.1 IFNG IL17A IL1B IL6 TNF
15 negative regulation of neurogenesis GO:0050768 10.09 TNF IL6 IL1B
16 positive regulation of osteoclast differentiation GO:0045672 10.09 TNF IL17A IFNG
17 positive regulation of glial cell proliferation GO:0060252 10.06 IL1B IL6 TNF
18 positive regulation of membrane protein ectodomain proteolysis GO:0051044 10.04 TNF IL1B IFNG
19 positive regulation of chemokine production GO:0032722 10.04 IFNG IL1B IL6 TNF
20 astrocyte activation GO:0048143 10.02 IFNG IL1B TNF
21 positive regulation of neuroinflammatory response GO:0150078 9.99 TNF IL6 IL1B
22 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.97 VEGFA TNF IL6 IL2 IFNG
23 humoral immune response GO:0006959 9.96 TNF IL6 IFNG HLA-DRB1 CCR6
24 negative regulation of lipid storage GO:0010888 9.95 TNF IL6 CRP
25 positive regulation of fever generation GO:0031622 9.94 TNF IL1B
26 sequestering of triglyceride GO:0030730 9.94 TNF IL1B
27 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.93 VEGFA ACE
28 positive regulation of nitrogen compound metabolic process GO:0051173 9.93 IFNG TNF
29 response to gold nanoparticle GO:1990268 9.91 TNF MPO
30 negative regulation of gap junction assembly GO:1903597 9.9 IL1B ACE
31 positive regulation of vitamin D biosynthetic process GO:0060557 9.89 TNF IFNG
32 vascular endothelial growth factor production GO:0010573 9.85 TNF IL6 IL1B
33 immune response GO:0006955 9.83 TNF IL6 IL2 IL1B IL17A IFNG
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 IFNG IL1B TNF
35 macrophage differentiation GO:0030225 9.32 VEGFA SOCS1 IFNG HLA-DRB1 CD4

Molecular functions related to Scleral Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.47 VEGFA TNF IL6 IL2 IL1B IL17A

Sources for Scleral Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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