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MCID: SCL013
MIFTS: 34

Scleral Disease

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Scleral Disease

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MalaCards integrated aliases for Scleral Disease:

Name: Scleral Disease 12 15
Scleral Diseases 45 74

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:11343
MeSH 45 D015422
NCIt 51 C79717
SNOMED-CT 69 33064008
ICD10 34 H15 H15.9
UMLS 74 C0036412
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Summaries for Scleral Disease

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MalaCards based summary : Scleral Disease, also known as scleral diseases, is related to arthritis and chorioretinitis, and has symptoms including eye manifestations An important gene associated with Scleral Disease is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are NF-kappaB Signaling and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. The drugs Melanocyte-Stimulating Hormones and beta-endorphin have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and bone.

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Related Diseases for Scleral Disease

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Diseases related to Scleral Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 arthritis 29.4 IL1RN TNF TNFRSF1B
2 chorioretinitis 10.3 MRAP SRCIN1
3 iritis 10.2 MRAP TNFRSF1B
4 tenosynovitis 10.2 MRAP TNFRSF1B
5 orbital plasma cell granuloma 10.2 MRAP TNFRSF1B
6 chronic orbital inflammation 10.2 MRAP TNFRSF1B
7 transient arthritis 10.2 MRAP TNFRSF1B
8 posterior scleritis 10.2 MRAP TNF
9 diffuse infiltrative lymphocytosis syndrome 10.2 MRAP TNF
10 coccidiosis 10.2 MRAP TNF
11 inclusion conjunctivitis 10.2 MRAP TNF
12 conjunctival disease 10.2 MRAP TNF
13 glaucomatocyclitic crisis 10.2 MRAP TNF
14 skin sarcoidosis 10.1 TNF TNFRSF1B
15 chronic gonococcal salpingitis 10.1 TNF TNFRSF1B
16 granulomatous dermatitis 10.1 TNF TNFRSF1B
17 chondromalacia 10.1 IL1RN TNFRSF1B
18 peroneal neuropathy 10.1 TNF TNFRSF1B
19 periodic fever, familial, autosomal dominant 10.1 TNF TNFRSF1B
20 post-transplant lymphoproliferative disease 10.1 TNF TNFRSF1B
21 chronic salpingitis 10.1 TNF TNFRSF1B
22 vulvar vestibulitis syndrome 10.1 IL1RN TNF
23 synovitis 10.1 IL1RN TNF
24 cogan syndrome 10.1 TNF TNFRSF1B
25 osteosclerotic myeloma 10.1 IL1RN TNF
26 melkersson-rosenthal syndrome 10.1 TNF TNFRSF1B
27 parasitic helminthiasis infectious disease 10.1 SRCIN1 TNF
28 aseptic meningitis 10.1 IL1RN TNF
29 joint disorders 10.1 IL1RN TNF
30 adult-onset still's disease 10.0 IL1RN TNF
31 dengue shock syndrome 10.0 IL1RN TNF
32 aphthous stomatitis 10.0 IL1RN TNF
33 idiopathic neutropenia 10.0 IL1RN TNF
34 guillain-barre syndrome 10.0 TNF TNFRSF1B
35 peptic ulcer disease 10.0 IL1RN TNF
36 pericarditis 10.0 IL1RN TNF
37 brucellosis 10.0 IL1RN TNF
38 temporal arteritis 10.0 IL1RN TNF
39 silicosis 10.0 IL1RN TNF
40 alopecia areata 10.0 IL1RN TNF
41 acute salpingitis 10.0 MRAP TNF TNFRSF1B
42 panuveitis 10.0 MRAP TNF TNFRSF1B
43 palindromic rheumatism 10.0 MRAP TNF TNFRSF1B
44 atrophic gastritis 9.9 IL1RN TNF
45 uveal disease 9.9 MRAP TNF TNFRSF1B
46 spondyloarthropathy 1 9.9 MRAP TNF TNFRSF1B
47 aggressive periodontitis 9.9 IL1RN TNF
48 duodenal ulcer 9.9 IL1RN TNF
49 primary bacterial infectious disease 9.9 TNF TNFRSF1B
50 chorioamnionitis 9.9 IL1RN TNF

Graphical network of the top 20 diseases related to Scleral Disease:



Diseases related to Scleral Disease
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Symptoms & Phenotypes for Scleral Disease

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UMLS symptoms related to Scleral Disease:


eye manifestations
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Drugs & Therapeutics for Scleral Disease

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Drugs for Scleral Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Melanocyte-Stimulating Hormones Phase 4,Phase 2
2 beta-endorphin Phase 4,Phase 2
3 Adrenocorticotropic Hormone Phase 4,Phase 2
4 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
5 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
6 Hormones Phase 4,Phase 3,Phase 2,Phase 1
7
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
8
Infliximab Approved Phase 3,Phase 1 170277-31-3
9
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
10
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
11 Immunologic Factors Phase 3,Phase 1,Phase 2
12 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
13 Antirheumatic Agents Phase 3,Phase 1,Phase 2
14 Dermatologic Agents Phase 3,Phase 1
15 Antineoplastic Agents, Hormonal Phase 3,Phase 1
16 Gastrointestinal Agents Phase 3,Phase 1
17 glucocorticoids Phase 3,Phase 1
18 Anti-Inflammatory Agents Phase 3,Phase 1
19 Alkylating Agents Phase 3
20 Antineoplastic Agents, Alkylating Phase 3
21
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
22
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 5284616 6436030
23
Everolimus Approved Phase 1, Phase 2 159351-69-6 70789204 6442177
24
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
25
Tofacitinib Approved, Investigational Phase 2 477600-75-2
26 Antibiotics, Antitubercular Phase 1, Phase 2
27 Anti-Infective Agents Phase 1, Phase 2
28 Anti-Bacterial Agents Phase 1, Phase 2
29 Antifungal Agents Phase 1, Phase 2
30 Antineoplastic Agents, Immunological Phase 1, Phase 2
31 Endorphins Phase 2
32 Neurotransmitter Agents Phase 2
33 Protein Kinase Inhibitors Phase 2
34
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
35
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
36 Ophthalmic Solutions Phase 1
37 Antiemetics Phase 1
38
protease inhibitors Phase 1
39 HIV Protease Inhibitors Phase 1
40 BB 1101 Phase 1
41 Dexamethasone 21-phosphate Phase 1
42 Peripheral Nervous System Agents Phase 1
43 Pharmaceutical Solutions Phase 1
44 Autonomic Agents Phase 1
45
Azathioprine Approved 446-86-6 2265
46
Mycophenolic acid Approved 24280-93-1 446541
47
Adalimumab Approved 331731-18-1 16219006
48
Etanercept Approved, Investigational 185243-69-0
49
Methylprednisolone hemisuccinate Approved 2921-57-5
50
Prednisolone phosphate Approved, Vet_approved 302-25-0

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
2 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 3 Infliximab;Cyclophosphamide
3 Gevokizumab for Active Scleritis Completed NCT01835132 Phase 1, Phase 2
4 Sirolimus Injections for Autoimmune Scleritis Completed NCT01517074 Phase 1, Phase 2 Sirolimus
5 Rituximab in the Treatment of Scleritis and Non-Infectious Orbital Inflammation Completed NCT00415506 Phase 1, Phase 2 Rituximab
6 A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis Recruiting NCT03465111 Phase 2 ACTH (adrenocorticotropic hormone) gel
7 Tofacitinib for Inflammatory Eye Disease Recruiting NCT03580343 Phase 2 tofacitinib
8 Iontophoresis Delivery of Dexamethasone Phosphate for Non-infectious, Non-necrotizing Anterior Scleritis, Phase 1 Dose-varying Study Completed NCT01059955 Phase 1 Dexamethasone Phosphate Ophthalmic Solution (EGP-437);Dexamethasone phosphate ophthalmic solution
9 Infliximab to Treat Non-Infectious Scleritis Completed NCT00075075 Phase 1 Infliximab
10 Study Evaluating PSI-697 in Patients With Scleritis Terminated NCT00367692 Phase 1 PSI-697
11 Causes of Visual Loss in Retinal Disease Unknown status NCT01613963 Immunosuppressive Agents
12 Perichondrium Autograft in Refractory Necrotizing Scleritis Completed NCT02864823 Not Applicable
13 Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis Completed NCT01958567 Not Applicable
14 Human Samples and Data Repository Completed NCT00539370
15 LSFG-SKIN, Laser Speckle Flowgraphy Completed NCT03660618 Not Applicable
16 Ocular Manifestations in Rheumatic Diseases Active, not recruiting NCT03753893

Search NIH Clinical Center for Scleral Disease

Cochrane evidence based reviews: scleral diseases

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Genetic Tests for Scleral Disease

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Anatomical Context for Scleral Disease

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MalaCards organs/tissues related to Scleral Disease:

42
Eye, Skin, Bone
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Publications for Scleral Disease

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Articles related to Scleral Disease:

# Title Authors Year
1
Destructive corneal and scleral disease associated with rheumatoid arthritis. Medical and surgical management. ( 7671613 )
1995
2
Ultrasound biomicroscopy in the assessment of anterior scleral disease. ( 8238225 )
1993
3
Progression of scleral disease. ( 2052300 )
1991
4
'Pulsed' immunosuppressive therapy in the treatment of immunologically induced corneal and scleral disease. ( 3443202 )
1987
5
Rheumatic disease in patients suffering from scleral disease. ( 5427425 )
1970
6
Management of scleral disease. ( 5226566 )
1966
7
Slitlamp diagnosis of corneal and scleral disease. ( 13080411 )
1953
8
Some contemporary concepts of scleral disease. ( 14902177 )
1951
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Variations for Scleral Disease

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Expression for Scleral Disease

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Search GEO for disease gene expression data for Scleral Disease.
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Pathways for Scleral Disease

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Pathways related to Scleral Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
11.95 IL1RN TNF TNFRSF1B
2
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 23
Show member pathways
 11.3 TNF TNFRSF1B
3
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.26 IL1RN TNF
4
Adipocytokine signaling pathway 38
11.21 TNF TNFRSF1B
5
Transcription_NF-kB signaling pathway 23
11.05 TNF TNFRSF1B
6
Cellular Transformation by HTLV1 65
Show member pathways
 10.85 TNF TNFRSF1B
7
Interleukin-10 signaling 67
10.49 IL1RN TNF TNFRSF1B
8
14-3-3 and Regulation of BAD Activity 65
10.46 TNF TNFRSF1B
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GO Terms for Scleral Disease

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Biological processes related to Scleral Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.63 IL1RN TNF TNFRSF1B
2 cytokine-mediated signaling pathway GO:0019221 9.5 IL1RN TNF TNFRSF1B
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.49 TNF TNFRSF1B
4 response to glucocorticoid GO:0051384 9.48 IL1RN TNF
5 positive regulation of interleukin-6 production GO:0032755 9.43 IL1RN TNF
6 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.4 TNF TNFRSF1B
7 extrinsic apoptotic signaling pathway GO:0097191 9.37 TNF TNFRSF1B
8 cellular response to lipopolysaccharide GO:0071222 9.33 IL1RN TNF TNFRSF1B
9 positive regulation of JUN kinase activity GO:0043507 8.96 TNF
10 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.96 TNF TNFRSF1B
11 chronic inflammatory response to antigenic stimulus GO:0002439 8.32 TNF
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Sources for Scleral Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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