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MCID: SCL013
MIFTS: 37

Scleral Disease

Categories: Eye diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Scleral Disease

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MalaCards integrated aliases for Scleral Disease:

Name: Scleral Disease 12 15
Scleral Diseases 44 70

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Eye diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:11343
MeSH 44 D015422
NCIt 50 C79717
SNOMED-CT 67 33064008
ICD10 32 H15
UMLS 70 C0036412
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Summaries for Scleral Disease

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Disease Ontology : 12 An eye disease that affects the sclera, which is the white fibrous outer layer of the eyeball.

MalaCards based summary : Scleral Disease, also known as scleral diseases, is related to anterior scleritis and scleritis, and has symptoms including eye manifestations An important gene associated with Scleral Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include eye, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

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Related Diseases for Scleral Disease

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Diseases in the Scleral Disease family:

Rare Scleral Disorder

Diseases related to Scleral Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 898)
# Related Disease Score Top Affiliating Genes
1 anterior scleritis 29.9 TNF PRTN3 CRP ACE
2 scleritis 29.7 TNF PRTN3 MPO IFNG CRP CCR6
3 posterior scleritis 29.2 VEGFA TNFRSF10A TNF PRTN3 CRP ACE
4 keratitis, hereditary 28.1 VEGFA TNF IL6 IL1B IL17A CD8A
5 episcleritis periodica fugax 11.0
6 scleromalacia perforans 11.0
7 nodular episcleritis 11.0
8 drug reaction with eosinophilia and systemic symptoms 10.4 TNF CRP
9 allergic cutaneous vasculitis 10.4 PRTN3 MPO
10 autoimmune inner ear disease 10.4 TNF MPO
11 frontal sinusitis 10.4 PRTN3 CRP
12 acute dacryoadenitis 10.4 CRP ACE
13 mediastinum teratoma 10.4 CRP ACE
14 orbital plasma cell granuloma 10.4 PRTN3 CRP
15 bicipital tenosynovitis 10.4 PRTN3 CRP
16 cardiac tuberculosis 10.4 CRP ACE
17 external pathological resorption 10.4 TNF IL6
18 scorpion envenomation 10.4 TNF IL6
19 ethmoid sinusitis 10.4 PRTN3 CRP
20 wissler-fanconi syndrome 10.4 PRTN3 CD4
21 acute frontal sinusitis 10.3 PRTN3 MPO
22 tuberculous epididymitis 10.3 TNF CRP
23 idiopathic anterior uveitis 10.3 TNF IL6
24 cold agglutinin disease 10.3 IL6 CRP
25 purulent acute otitis media 10.3 PRTN3 MPO CRP
26 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 TNF IL6
27 toxic megacolon 10.3 TNF CRP CCR6
28 cardiogenic shock 10.3 TNF IL6
29 chromium allergic contact dermatitis 10.3 IL2 IL17A
30 enthesopathy 10.3 TNF CRP CCR6
31 epidural abscess 10.3 CRP CD4
32 subacute bacterial endocarditis 10.3 PRTN3 MPO CRP
33 mastoiditis 10.3 PRTN3 MPO CRP
34 maxillary sinusitis 10.3 PRTN3 MPO CRP
35 mikulicz disease 10.3 CRP CD4 CCR6
36 urogenital tuberculosis 10.3 CRP CD4
37 rheumatoid arthritis interstitial lung disease 10.3 TNF CRP CD4
38 coccidioidomycosis 10.3 IL17A CD4 CCR6
39 rapidly progressive glomerulonephritis 10.3 PRTN3 MPO CRP
40 cryopyrin-associated periodic syndrome 10.3 IL6 CRP
41 tolosa-hunt syndrome 10.3 PRTN3 CRP ACE
42 silent myocardial infarction 10.3 CRP ACE
43 chronic orbital inflammation 10.3 PRTN3 CRP ACE
44 critical illness polyneuropathy 10.3 TNF CRP
45 granulomatous angiitis 10.3 PRTN3 CRP ACE
46 breast abscess 10.3 CRP CD4
47 cholesterol embolism 10.3 PRTN3 CRP ACE
48 louse-borne relapsing fever 10.3 TNF CRP
49 keratoconjunctivitis sicca 10.3 TNF CD4 CCR6
50 sialadenitis 10.3 TNF CD4 CCR6

Graphical network of the top 20 diseases related to Scleral Disease:



Diseases related to Scleral Disease
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Symptoms & Phenotypes for Scleral Disease

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UMLS symptoms related to Scleral Disease:


eye manifestations

GenomeRNAi Phenotypes related to Scleral Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.36 IL17A IL1B MPO TNF TNFRSF10A
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.36 ACE IL17A IL1B IL2 MPO TNF

MGI Mouse Phenotypes related to Scleral Disease:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 ACE CCR6 CD4 CD8A IFNG IL17A
2 immune system MP:0005387 10.27 ACE CCR6 CD4 CD8A CRP IFNG
3 homeostasis/metabolism MP:0005376 10.25 ACE CCR6 CD4 CRP IFNG IL17A
4 endocrine/exocrine gland MP:0005379 10.2 ACE CD4 CD8A IFNG IL17A IL2
5 cardiovascular system MP:0005385 10.19 ACE CRP IFNG IL1B IL2 IL6
6 digestive/alimentary MP:0005381 10.08 CD4 IFNG IL17A IL2 IL6 SOCS1
7 integument MP:0010771 9.97 CD4 CD8A IFNG IL17A IL1B IL6
8 mortality/aging MP:0010768 9.97 ACE CD4 CD8A IFNG IL17A IL1B
9 liver/biliary system MP:0005370 9.8 ACE IFNG IL2 IL6 SOCS1 TNF
10 neoplasm MP:0002006 9.61 ACE IFNG IL1B IL2 IL6 SOCS1
11 no phenotypic analysis MP:0003012 9.23 CD4 IFNG IL17A IL2 PRTN3 TNF
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Drugs & Therapeutics for Scleral Disease

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Search Clinical Trials , NIH Clinical Center for Scleral Disease

Cochrane evidence based reviews: scleral diseases

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Genetic Tests for Scleral Disease

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Anatomical Context for Scleral Disease

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MalaCards organs/tissues related to Scleral Disease:

40
Eye
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Publications for Scleral Disease

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Articles related to Scleral Disease:

(show all 26)
# Title Authors PMID Year
1
Identification of multipotent stem/progenitor cells in murine sclera. 61
21788434 2011
2
Enteric-coated mycophenolate sodium as a corticosteroid-sparing agent for the treatment of autoimmune scleritis. 61
21099416 2011
3
Human sclera maintains common characteristics with cartilage throughout evolution. 61
19002264 2008
4
Retinoblastoma patients with high risk ocular pathological features: who needs adjuvant therapy? 61
15258027 2004
5
Scleral nodule associated with sarcoidosis. 61
14516826 2003
6
Ultrasound biomicroscopy in scleritis. 61
9499786 1998
7
Successful management of Aspergillus scleritis by medical and surgical treatment. 61
9683961 1998
8
[New clinical and epidemiologic aspects of episcleritis and scleritis]. 61
9181836 1997
9
Scanning electron-microscopic studies of the collagen architecture of the human sclera--normal and pathological findings. 61
8738455 1996
10
Destructive corneal and scleral disease associated with rheumatoid arthritis. Medical and surgical management. 61
7671613 1995
11
Ultrasound biomicroscopy in the assessment of anterior scleral disease. 61
8238225 1993
12
Progression of scleral disease. 61
2052300 1991
13
[Treatment of corneal and scleral diseases with the excimer laser. A preliminary report of experiences]. 61
2358264 1990
14
Current concepts in the management of scleritis. 61
3052526 1988
15
Anterior segment fluorescein angiography in the surgery of immunologically induced corneal and scleral destructive disorders. 61
3317186 1987
16
'Pulsed' immunosuppressive therapy in the treatment of immunologically induced corneal and scleral disease. 61
3443202 1987
17
Changes at the periphery of a lesion in necrotising scleritis: anterior segment fluorescein angiography correlated with electron microscopy. 61
4041412 1985
18
Microscopical studies of necrotising scleritis. I. Cellular aspects. 61
6498132 1984
19
Ultrastructural studies of corneal collagen during the development of experimental scleritis in rabbits. 61
6455278 1981
20
Destructive corneal disease in the connective tissue disorders. Comparison with an experimental animal model. 61
38536 1978
21
Senile scleral plaques and senile scleromalacia. 61
666986 1978
22
Scleritis and associated disease. 61
620214 1978
23
Rheumatic disease in patients suffering from scleral disease. 61
5427425 1970
24
Management of scleral disease. 61
5226566 1966
25
Slitlamp diagnosis of corneal and scleral disease. 61
13080411 1953
26
Some contemporary concepts of scleral disease. 61
14902177 1951
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Variations for Scleral Disease

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Expression for Scleral Disease

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Search GEO for disease gene expression data for Scleral Disease.
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Pathways for Scleral Disease

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Pathways related to Scleral Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.01 VEGFA TNF SOCS1 PRTN3 MPO IL6
2
ERK Signaling 63
Show member pathways
 13.85 VEGFA TNFRSF10A TNF IL6 IL2 IL1B
3
PEDF Induced Signaling 63
Show member pathways
 13.7 TNFRSF10A TNF SOCS1 IL6 IL2 IL1B
4
TGF-Beta Pathway 63
Show member pathways
 13.56 VEGFA TNFRSF10A TNF SOCS1 IL6 IL2
5
Akt Signaling 63
Show member pathways
 13.44 TNFRSF10A TNF IL6 IL2 IL1B IL17A
6
Cytokine Signaling in Immune system 65
Show member pathways
 13.39 VEGFA TNF SOCS1 PRTN3 IL6 IL2
7
PAK Pathway 63
Show member pathways
 13.34 TNFRSF10A TNF IL6 IL2 IL1B IL17A
8
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.25 TNFRSF10A TNF SOCS1 IL6 IL2 IL1B
9
Measles 36
Show member pathways
 12.87 TNFRSF10A TNF IL6 IL2 IL1B IFNG
10
Allograft rejection 1 36
Show member pathways
 12.8 VEGFA TNF IL6 IL2 IL1B IL17A
11
Th17 cell differentiation 36
Show member pathways
 12.67 TNF IL6 IL2 IL1B IL17A IFNG
12
T cell receptor signaling pathway 36
Show member pathways
 12.64 TNF IL6 IL2 IL1B IL17A IFNG
13
Immune response IL-23 signaling pathway 23
Show member pathways
 12.61 TNF MPO IL6 IL2 IL1B IL17A
14
NF-kappaB Signaling 4
12.55 TNF SOCS1 MPO IL2 IL1B IL17A
15
JAK-STAT signaling pathway 36
Show member pathways
 12.44 SOCS1 IL6 IL2 IFNG
16
IL-17 Family Signaling Pathways 64
Show member pathways
 12.4 TNF IL6 IL1B IL17A IFNG
17
Folate Metabolism 1
Show member pathways
 12.4 TNF MPO IL6 IL2 IL1B IFNG
18
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.39 TNFRSF10A TNF IL6 IL2 CCR6
19
Human T-cell leukemia virus 1 infection 36
12.38 TNF IL6 IL2 CD4
20
Toll Comparative Pathway 63
Show member pathways
 12.34 TNF IL6 IL1B IFNG
21
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.33 TNF SOCS1 IL6 IL2 IL1B IL17A
22
Toxoplasmosis 36
Show member pathways
 12.31 TNF SOCS1 IL1B IFNG
23
Tuberculosis 36
12.28 TNF IL6 IL1B IFNG
24
C-type lectin receptor signaling pathway 36
Show member pathways
 12.26 TNF IL6 IL2 IL1B
25
Necroptosis 36
Show member pathways
 12.25 TNFRSF10A TNF IL1B IFNG
26
Colorectal Cancer Metastasis 63
12.23 VEGFA TNF IL6 IFNG
27
Bacterial infections in CF airways 23
Show member pathways
 12.23 TNF IL6 IL1B IFNG
28
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.22 VEGFA TNF IL6 IL1B
29
Yersinia infection 36
12.17 TNF IL6 IL2 IL1B CD8A CD4
30
Fluid shear stress and atherosclerosis 36
12.14 VEGFA TNF IL1B IFNG
31
Osteoclast differentiation 36
12.1 TNF SOCS1 IL1B IFNG
32
Spinal Cord Injury 1
12.09 TNF IL6 IL2 IL1B IFNG
33
Interleukin-4 and 13 signaling 65
12.08 VEGFA TNF SOCS1 IL6 IL1B IL17A
34
IL12-mediated signaling events 1
Show member pathways
 12.07 SOCS1 IL2 IL1B IFNG CD8A CD4
35
Hematopoietic cell lineage 36
12 TNF IL6 IL1B CD8A CD4
36
Amoebiasis 36
11.99 TNF IL6 IL1B IFNG
37
AGE-RAGE signaling pathway in diabetic complications 36
11.98 VEGFA TNF IL6 IL1B
38
Th17 Differentiation Pathway 64
Show member pathways
 11.96 IL6 IL1B IL17A IFNG CD4
39
Rheumatoid arthritis 36
11.96 VEGFA TNF IL6 IL1B IL17A IFNG
40
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.93 TNF MPO IL6 IL2 IFNG CD8A
41
Immune response IFN gamma signaling pathway 23
Show member pathways
 11.89 SOCS1 IL1B IFNG
42
Glucocorticoid receptor regulatory network 1
11.83 IL6 IL2 IFNG
43
C-MYB transcription factor network 1
11.81 PRTN3 MPO CD4
44
Pertussis 36
11.8 TNF IL6 IL1B
45
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.79 TNF IL2 IFNG
46
IgA-Producing B Cells in the Intestine 64
11.73 TNF IL6 CCR6
47
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.73 TNF IL2 IFNG CD8A
48
Lung fibrosis 1
11.71 TNF IL6 IL1B
49
Th1 Differentiation Pathway 64
Show member pathways
 11.68 TNF IL6 IL2 IL1B IL17A IFNG
50
Legionellosis 36
11.66 TNF IL6 IL1B
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GO Terms for Scleral Disease

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Cellular components related to Scleral Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 VEGFA TNF RBP3 PRTN3 MPO IL6
2 external side of plasma membrane GO:0009897 9.63 TNF IL17A CD8A CD4 CCR6 ACE
3 membrane raft GO:0045121 9.56 TNFRSF10A TNF PRTN3 CD4
4 extracellular region GO:0005576 9.44 VEGFA TNF RBP3 PRTN3 MPO IL6

Biological processes related to Scleral Disease according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.1 VEGFA PRTN3 IL6 IL2 IL1B IFNG
2 adaptive immune response GO:0002250 10.07 IL2 IL17A IFNG CD8A CD4
3 positive regulation of gene expression GO:0010628 10.06 VEGFA TNF IL6 IL1B IFNG CRP
4 inflammatory response GO:0006954 10.05 TNF IL6 IL1B IL17A CRP
5 defense response to Gram-positive bacterium GO:0050830 9.89 TNF IL6 IL17A CRP
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.87 VEGFA IL6 CD4
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.87 VEGFA TNF IL6
8 positive regulation of tumor necrosis factor production GO:0032760 9.87 IL6 IL17A IFNG
9 positive regulation of inflammatory response GO:0050729 9.87 TNF IL2 IL1B IFNG
10 defense response to Gram-negative bacterium GO:0050829 9.86 IL6 IL17A CD4
11 positive regulation of interferon-gamma production GO:0032729 9.85 TNF IL2 IL1B
12 positive regulation of interleukin-8 production GO:0032757 9.85 TNF IL6 IL1B
13 positive regulation of protein complex assembly GO:0031334 9.85 VEGFA TNF IFNG
14 positive regulation of phagocytosis GO:0050766 9.83 TNF IL1B IFNG
15 regulation of insulin secretion GO:0050796 9.83 TNF IL6 IL1B IFNG
16 extrinsic apoptotic signaling pathway GO:0097191 9.82 TNFRSF10A TNF IFNG
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 TNF IL1B IFNG
18 positive regulation of chemokine production GO:0032722 9.81 TNF IL6 IFNG
19 positive regulation of T cell proliferation GO:0042102 9.81 IL6 IL2 IL1B CD4
20 positive regulation of protein phosphorylation GO:0001934 9.8 VEGFA TNF IL2 IL1B IFNG CD4
21 negative regulation of neurogenesis GO:0050768 9.78 TNF IL6 IL1B
22 humoral immune response GO:0006959 9.78 TNF IL6 IFNG CCR6
23 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.77 TNF IL6 IL17A
24 positive regulation of interleukin-6 production GO:0032755 9.77 TNF IL6 IL1B IL17A IFNG
25 positive regulation of interleukin-1 beta production GO:0032731 9.76 TNF IL6 IL17A IFNG
26 positive regulation of osteoclast differentiation GO:0045672 9.75 TNF IL17A IFNG
27 macrophage differentiation GO:0030225 9.73 VEGFA IFNG CD4
28 positive regulation of glial cell proliferation GO:0060252 9.72 TNF IL6 IL1B
29 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 TNF IL1B IFNG
30 negative regulation of amyloid-beta clearance GO:1900222 9.69 TNF IFNG
31 regulation of establishment of endothelial barrier GO:1903140 9.68 TNF IL1B
32 neutrophil mediated immunity GO:0002446 9.68 IL6 ACE
33 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.67 VEGFA ACE
34 positive regulation of neuroinflammatory response GO:0150078 9.67 TNF IL6 IL1B
35 positive regulation of interleukin-23 production GO:0032747 9.66 IL17A IFNG
36 positive regulation of fever generation GO:0031622 9.66 TNF IL1B
37 sequestering of triglyceride GO:0030730 9.64 TNF IL1B
38 negative regulation of gap junction assembly GO:1903597 9.62 IL1B ACE
39 positive regulation of vitamin D biosynthetic process GO:0060557 9.62 TNF IFNG
40 positive regulation of nitrogen compound metabolic process GO:0051173 9.61 TNF IFNG
41 negative regulation of lipid storage GO:0010888 9.61 TNF IL6 CRP
42 immune response GO:0006955 9.61 TNF IL6 IL2 IL1B IL17A IFNG
43 vascular endothelial growth factor production GO:0010573 9.58 TNF IL6 IL1B
44 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.55 VEGFA TNF IL6 IL2 IFNG
45 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 TNF IL1B IFNG
46 cytokine-mediated signaling pathway GO:0019221 9.28 VEGFA TNF SOCS1 PRTN3 IL6 IL2

Molecular functions related to Scleral Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 VEGFA TNFRSF10A TNF SOCS1 RBP3 PRTN3
2 cytokine activity GO:0005125 9.17 VEGFA TNF IL6 IL2 IL1B IL17A
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Sources for Scleral Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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