MCID: SCL014
MIFTS: 23

Scleral Staphyloma

Categories: Eye diseases

Aliases & Classifications for Scleral Staphyloma

MalaCards integrated aliases for Scleral Staphyloma:

Name: Scleral Staphyloma 12 15 73
Scleral Ectasia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11595
ICD10 33 H15.84
ICD9CM 35 379.11
UMLS 73 C0155359

Summaries for Scleral Staphyloma

MalaCards based summary : Scleral Staphyloma, also known as scleral ectasia, is related to papillorenal syndrome and retinal detachment. An important gene associated with Scleral Staphyloma is PAX2 (Paired Box 2). The drugs Bupivacaine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and bone, and related phenotypes are embryo and hearing/vestibular/ear

Related Diseases for Scleral Staphyloma

Diseases related to Scleral Staphyloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 papillorenal syndrome 11.5
2 retinal detachment 10.4
3 rhinosporidiosis 10.2
4 nevus, epidermal 10.1
5 ehlers-danlos syndrome 10.1
6 toxoplasmosis 10.1
7 congenital aphakia 10.0 OPTN PAX2
8 myopia 10.0
9 acanthamoeba keratitis 10.0
10 retinochoroidal coloboma 10.0
11 coloboma of macula 9.9 OPTN PAX2
12 nephrogenic adenofibroma 9.9 NF1 PAX2
13 hypotropia 9.9 NF1 OPTN
14 optic nerve neoplasm 9.8 NF1 OPTN
15 exophthalmos 9.8 NF1 OPTN
16 optic nerve glioma 9.8 NF1 OPTN
17 holoprosencephaly 9.8 FOXG1 LRP2

Graphical network of the top 20 diseases related to Scleral Staphyloma:



Diseases related to Scleral Staphyloma

Symptoms & Phenotypes for Scleral Staphyloma

MGI Mouse Phenotypes related to Scleral Staphyloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.56 FOXG1 LRP2 NF1 PAX2
2 hearing/vestibular/ear MP:0005377 9.46 FOXG1 LRP2 NF1 PAX2
3 pigmentation MP:0001186 9.26 FOXG1 LRP2 NF1 PAX2
4 vision/eye MP:0005391 8.92 FOXG1 LRP2 NF1 PAX2

Drugs & Therapeutics for Scleral Staphyloma

Drugs for Scleral Staphyloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
4 Anesthetics, Local Phase 4
5 Sodium Channel Blockers Phase 4
6 Neuromuscular Blocking Agents Phase 4
7 Anti-Arrhythmia Agents Phase 4
8 Cholinergic Antagonists Phase 4
9 Central Nervous System Depressants Phase 4
10 Diuretics, Potassium Sparing Phase 4
11 Anesthetics Phase 4
12 Neurotransmitter Agents Phase 4
13 Peripheral Nervous System Agents Phase 4
14 Pharmaceutical Solutions Phase 4
15 Cholinergic Agents Phase 4
16 Neuromuscular Agents Phase 4
17 Neuromuscular Nondepolarizing Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Adding Atracurium to Percaruncular Block for High Myopes Undergoing Cataract Surgery Completed NCT03243500 Phase 4 Atracurium;Lidocaine 2%;Bupivacaine 0.5%;hyaluronidase powder
2 The Relationship Between Structure and Visual Function in Myopia Foveoschisis Unknown status NCT02915133
3 Macular Buckle With Three-armed Silicone Completed NCT02169635 Not Applicable
4 Vitrectomy and Scleral Shortening for Macular Hole Retinal Detachment or Myopic Traction Maculopathy Completed NCT02528045
5 Optical Coherence Tomography Imaging of the Posterior Segment in High Myopia. Completed NCT00347451

Search NIH Clinical Center for Scleral Staphyloma

Genetic Tests for Scleral Staphyloma

Anatomical Context for Scleral Staphyloma

MalaCards organs/tissues related to Scleral Staphyloma:

41
Eye, Brain, Bone

Publications for Scleral Staphyloma

Articles related to Scleral Staphyloma:

(show all 19)
# Title Authors Year
1
Partial regression of large anterior scleral staphyloma secondary to rhinosporidiosis after corneoscleral graft - a case report. ( 29486755 )
2018
2
The relationship between scleral staphyloma and choroidal thinning in highly myopic eyes: The Beijing Eye Study. ( 28852194 )
2017
3
Secondary Bruch's membrane defects and scleral staphyloma in toxoplasmosis. ( 27040331 )
2016
4
Epidermal nevus syndrome associated with anterior scleral staphyloma and ectopic bone and cartilaginous intraocular tissue. ( 20151270 )
2010
5
Bilateral senile scleral plaques mimicking post-inflammatory scleral ectasia. ( 15132382 )
2004
6
Congenital anterior scleral staphyloma in an otherwise normal eye. ( 12691236 )
2003
7
Congenital scleral staphyloma in a dog repaired with preserved homologous peritoneum. ( 11397279 )
2000
8
Scleral ectasia as a complication of deep sclerectomy. ( 10831914 )
2000
9
Scleral ectasia in rhegmatogenous retinal detachment. ( 8872376 )
1996
10
Anterior scleral staphyloma associated with neurofibromatosis. ( 1741610 )
1991
11
Homograft of preserved sclera for post-traumatic scleral staphyloma in Ehlers-Danlos syndrome. ( 3710179 )
1986
12
Retinal detachment and scleral staphyloma. ( 4453405 )
1974
13
Ectopic brain tissue in a limbal dermoid associated with a scleral staphyloma. ( 4759859 )
1973
14
Rhinosporidium granuloma of the conjunctiva with scleral ectasia. ( 5458682 )
1970
15
Rhinosporidiosis manifesting as an unusual scleral staphyloma. ( 5370824 )
1969
16
Equatorial scleral staphyloma; surgical treatment in a case with retinal detachment. ( 14388088 )
1955
17
Scleral staphyloma and retinal detachment. ( 18135468 )
1949
18
Scleral Staphyloma and Retinal Detachment. ( 16693493 )
1948
19
Equatorial Scleral Staphyloma and Retinal Detachment Cured by Excision. ( 16693236 )
1940

Variations for Scleral Staphyloma

Expression for Scleral Staphyloma

Search GEO for disease gene expression data for Scleral Staphyloma.

Pathways for Scleral Staphyloma

GO Terms for Scleral Staphyloma

Biological processes related to Scleral Staphyloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 8.96 FOXG1 PAX2
2 neural tube closure GO:0001843 8.62 LRP2 PAX2

Sources for Scleral Staphyloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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