MCID: SCL014
MIFTS: 23

Scleral Staphyloma

Categories: Eye diseases, Neuronal diseases
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Aliases & Classifications for Scleral Staphyloma

MalaCards integrated aliases for Scleral Staphyloma:

Name: Scleral Staphyloma 11 14 71 33
Staphyloma of Sclera 33
Scleral Ectasia 11

Classifications:



External Ids:

Disease Ontology 11 DOID:11595
SNOMED-CT 68 111534007
ICD11 33 1938712729
UMLS 71 C0155359

Summaries for Scleral Staphyloma

MalaCards based summary: Scleral Staphyloma, also known as staphyloma of sclera, is related to papillorenal syndrome and keratitis, hereditary. An important gene associated with Scleral Staphyloma is PAX2 (Paired Box 2). Affiliated tissues include eye, retina and bone.

Related Diseases for Scleral Staphyloma

Diseases related to Scleral Staphyloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 papillorenal syndrome 32.2 PAX2 CRYAA
2 keratitis, hereditary 29.9 PAX2 CRYAA
3 degenerative myopia 29.8 SHISA6 CCDC102B
4 myopia 29.7 SHISA6 GOLGA8B CRYAA CCDC102B
5 reticular dystrophy of retinal pigment epithelium 11.2
6 retinal detachment 10.4
7 rhinosporidiosis 10.2
8 macular holes 10.2
9 herpes zoster 10.2
10 uveitis 10.1
11 coloboma of optic nerve 10.1 PAX2 CRYAA
12 persistent hyperplastic primary vitreous 10.1 PAX2 CRYAA
13 aniridia 1 10.0 PAX2 CRYAA
14 glioma susceptibility 1 10.0
15 nevus, epidermal 10.0
16 schimmelpenning-feuerstein-mims syndrome 10.0
17 strabismus 10.0
18 ehlers-danlos syndrome, kyphoscoliotic type, 1 10.0
19 retinoschisis 1, x-linked, juvenile 10.0
20 ehlers-danlos syndrome 10.0
21 scleritis 10.0
22 neurofibromatosis 10.0
23 vitreous detachment 10.0
24 refractive error 10.0
25 toxoplasmosis 10.0
26 plod1-related kyphoscoliotic ehlers-danlos syndrome 10.0
27 glioma 10.0
28 glial tumor 10.0
29 morgagni cataract 10.0 CRYGA CRYAA
30 deprivation amblyopia 10.0 CRYGA CRYAA
31 amblyopia 10.0 CRYGA CRYAA
32 abruzzo-erickson syndrome 10.0 CRYGA CRYAA
33 retinitis pigmentosa 29 10.0 CRYGA CRYAA
34 posterior polar cataract 10.0 CRYGA CRYAA
35 axenfeld-rieger syndrome, type 3 9.9 CRYGA CRYAA
36 coloboma of macula 9.9
37 onchocerciasis 9.9
38 sclerosing keratitis 9.9
39 connective tissue disease 9.9
40 acanthamoeba keratitis 9.9
41 retinochoroidal coloboma 9.9
42 porencephaly 9.9 CRYGA CRYAA
43 alport syndrome 9.9 PAX2 CRYAA

Graphical network of the top 20 diseases related to Scleral Staphyloma:



Diseases related to Scleral Staphyloma

Symptoms & Phenotypes for Scleral Staphyloma

Drugs & Therapeutics for Scleral Staphyloma

Search Clinical Trials, NIH Clinical Center for Scleral Staphyloma

Genetic Tests for Scleral Staphyloma

Anatomical Context for Scleral Staphyloma

Organs/tissues related to Scleral Staphyloma:

MalaCards : Eye, Retina, Bone, Brain

Publications for Scleral Staphyloma

Articles related to Scleral Staphyloma:

(show top 50) (show all 89)
# Title Authors PMID Year
1
Three cases of macular hole that occurred in inferior scleral staphyloma associated with tilted disc syndrome: a case series. 62
35090537 2022
2
Clinical observation of vitrectomy combined with endolaser photocoagulation at the edge of posterior scleral staphyloma for macular hole retinal detachment in high myopia. 62
36262849 2022
3
[Analysis of the treatment effect of posterior scleral reinforcement on pathological myopia]. 62
34865456 2021
4
Lowering Intraocular Pressure: A Potential Approach for Controlling High Myopia Progression. 62
34787640 2021
5
Focal choroidal excavation: review of literature. 62
32788327 2021
6
[Macular buckling for highly myopic traction maculopathy]. 62
34098692 2021
7
Progressive development of large choroidal excavation in neovascular age-related macular degeneration. 62
33325252 2020
8
RD repair using 360-degree scleral graft for extensive scleral ectasia in a patient with Ehlers Danlos syndrome. 62
32083221 2020
9
Bilateral Multiple Focal Choroidal Excavations in a Patient with Paroxysmal Nocturnal Hemoglobinuria (PNH). 62
31915557 2019
10
Macular Hole in Myopic Eyes: A Narrative Review of the Current Surgical Techniques. 62
30984418 2019
11
Partial regression of large anterior scleral staphyloma secondary to rhinosporidiosis after corneoscleral graft - a case report. 62
29486755 2018
12
Complications Assoicated with MIRAgel for Treatment of Retinal Detachment. 62
29144829 2018
13
[Clinical characteristics and surgical effect observation of congenital aniridia combined with cataract]. 62
29141386 2017
14
The relationship between scleral staphyloma and choroidal thinning in highly myopic eyes: The Beijing Eye Study. 62
28852194 2017
15
[Unilateral macular coloboma: about a case]. 62
29184607 2017
16
Secondary Bruch's membrane defects and scleral staphyloma in toxoplasmosis. 62
27040331 2016
17
Focal choroidal excavation: Clinical findings and complications. 62
26652731 2016
18
Spontaneous resealing of perforated scleral ectasia associated with atypical retinochoroidal coloboma. 62
25800772 2015
19
Posterior scleral reinforcement and vitrectomy for myopic foveoschisis in extreme myopia. 62
25111687 2015
20
Foxg1-Cre Mediated Lrp2 Inactivation in the Developing Mouse Neural Retina, Ciliary and Retinal Pigment Epithelia Models Congenital High Myopia. 62
26107939 2015
21
[Uveal schwannoma mimicking melanoma (case report)]. 62
24864500 2014
22
Intravitreal ranibizumab for the treatment of pathological myopia associated with choroidal neovascularization in Chinese patients. 62
25131225 2014
23
In vivo visualization of perforating vessels and focal scleral ectasia in pathological myopia. 62
24194186 2013
24
Scleral micro-RNA signatures in adult and fetal eyes. 62
24205357 2013
25
[Complications of deep nonpenetrating sclerectomy]. 62
23214459 2012
26
Large post-traumatic ciliary staphyloma--a simple, safe and successful management. 62
23360030 2012
27
Renal coloboma syndrome. 62
21654726 2011
28
The expanded spectrum of focal choroidal excavation. 62
21670327 2011
29
[Surgical treatment of a perforated scleral staphyloma in Wegener's granulomatosis]. 62
21328175 2011
30
Ocular rhinosporidiosis with staphyloma formation: a case with unusual features. 62
28539772 2011
31
Epidermal nevus syndrome associated with anterior scleral staphyloma and ectopic bone and cartilaginous intraocular tissue. 62
20151270 2010
32
Ophthalmic pathology of Nance-Horan syndrome: case report and review of the literature. 62
19941417 2009
33
Pars plana Baerveldt implantation for refractory childhood glaucomas. 62
19525734 2009
34
Bilateral staphylomas presenting as bitemporal hemianopia. 62
24299639 2007
35
Cannulation of the suprachoroidal space: a novel drug delivery methodology to the posterior segment. 62
16989764 2006
36
[A study on axis length measurement of high myopia with cataract]. 62
17162866 2005
37
Morning glory syndrome: clinical, computerized tomographic, and ultrasonographic findings. 62
16250218 2005
38
[A case report of injecting gentamicin intraocularly by mistake being misdiagnosed as central retinal artery occlusion]. 62
17165336 2005
39
Structural organization of choroidal colobomas of young and adult patients and mechanism of retinal detachment. 62
17057813 2005
40
Ocular manifestations and surgical management of lid coloboma in a Chinese infant with linear nevus sebaceous syndrome. 62
15478746 2004
41
Bilateral senile scleral plaques mimicking post-inflammatory scleral ectasia. 62
15132382 2004
42
Staphyloma in a cat. 62
12753608 2003
43
Congenital anterior scleral staphyloma in an otherwise normal eye. 62
12691236 2003
44
Presenting signs of retinoblastoma in Congolese patients. 62
12058485 2002
45
Scleral ectasia as a complication of deep sclerectomy. 62
10831914 2000
46
Conjunctival rhinosporidiosis associated with scleral melting and staphyloma formation: diagnosis and management. 62
10632005 2000
47
Congenital scleral staphyloma in a dog repaired with preserved homologous peritoneum. 62
11397279 2000
48
[Semi-annular pre-equatorial scleral ectasia in a patient with glaucoma and onchocerciasis]. 62
10609173 1999
49
[Diode laser cyclophotocoagulation of secondary glaucoma caused by anterior, necrotizing scleritis]. 62
9888136 1998
50
[Atypical constellation of findings in Schimmelpenning-Feuerstein-Mims syndrome--case report and overview]. 62
9782468 1998

Variations for Scleral Staphyloma

Expression for Scleral Staphyloma

Search GEO for disease gene expression data for Scleral Staphyloma.

Pathways for Scleral Staphyloma

GO Terms for Scleral Staphyloma

Biological processes related to Scleral Staphyloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lens development in camera-type eye GO:0002088 9.26 CRYGA CRYAA
2 visual perception GO:0007601 9.1 PAX2 CRYGA CRYAA

Molecular functions related to Scleral Staphyloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 8.92 CRYGA CRYAA

Sources for Scleral Staphyloma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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