MCID: SCL014
MIFTS: 24

Scleral Staphyloma

Categories: Neuronal diseases

Aliases & Classifications for Scleral Staphyloma

MalaCards integrated aliases for Scleral Staphyloma:

Name: Scleral Staphyloma 12 15 71
Scleral Ectasia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11595
ICD9CM 34 379.11
SNOMED-CT 67 111534007
ICD10 32 H15.84
UMLS 71 C0155359

Summaries for Scleral Staphyloma

MalaCards based summary : Scleral Staphyloma, also known as scleral ectasia, is related to papillorenal syndrome and keratitis, hereditary. An important gene associated with Scleral Staphyloma is PAX2 (Paired Box 2). The drugs Atropine and Respiratory System Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and bone.

Related Diseases for Scleral Staphyloma

Graphical network of the top 20 diseases related to Scleral Staphyloma:



Diseases related to Scleral Staphyloma

Symptoms & Phenotypes for Scleral Staphyloma

Drugs & Therapeutics for Scleral Staphyloma

Drugs for Scleral Staphyloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
2 Respiratory System Agents Phase 4
3 Parasympatholytics Phase 4
4 Pharmaceutical Solutions Phase 4
5 Cholinergic Agents Phase 4
6 Anti-Arrhythmia Agents Phase 4
7 Anti-Asthmatic Agents Phase 4
8 Ophthalmic Solutions Phase 4
9 Muscarinic Antagonists Phase 4
10 Cholinergic Antagonists Phase 4
11 Mydriatics Phase 4
12 Bronchodilator Agents Phase 4
13 Neurotransmitter Agents Phase 4
14 Anesthetics Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Atropine for Children and Adolescent Myopia Progression Study (ACAMP) Enrolling by invitation NCT03949101 Phase 4 Atropine Sulfate 1 % Ophthalmic Ointment and Atropine Sulfate 0.01% Eye Drop;atropine 0.01% eye drop
2 Shanghai Child and Adolescent Large-scale Eye Study -High Myopia Registration Enrolling by invitation NCT03666052

Search NIH Clinical Center for Scleral Staphyloma

Genetic Tests for Scleral Staphyloma

Anatomical Context for Scleral Staphyloma

MalaCards organs/tissues related to Scleral Staphyloma:

40
Eye, Retina, Bone, Brain

Publications for Scleral Staphyloma

Articles related to Scleral Staphyloma:

(show top 50) (show all 82)
# Title Authors PMID Year
1
RD repair using 360-degree scleral graft for extensive scleral ectasia in a patient with Ehlers Danlos syndrome. 61
32083221 2020
2
Bilateral Multiple Focal Choroidal Excavations in a Patient with Paroxysmal Nocturnal Hemoglobinuria (PNH). 61
31915557 2019
3
Macular Hole in Myopic Eyes: A Narrative Review of the Current Surgical Techniques. 61
30984418 2019
4
Partial regression of large anterior scleral staphyloma secondary to rhinosporidiosis after corneoscleral graft - a case report. 61
29486755 2018
5
Complications Assoicated with MIRAgel for Treatment of Retinal Detachment. 61
29144829 2018
6
[Clinical characteristics and surgical effect observation of congenital aniridia combined with cataract]. 61
29141386 2017
7
The relationship between scleral staphyloma and choroidal thinning in highly myopic eyes: The Beijing Eye Study. 61
28852194 2017
8
[Unilateral macular coloboma: about a case]. 61
29184607 2017
9
Secondary Bruch's membrane defects and scleral staphyloma in toxoplasmosis. 61
27040331 2016
10
Focal choroidal excavation: Clinical findings and complications. 61
26652731 2016
11
Spontaneous resealing of perforated scleral ectasia associated with atypical retinochoroidal coloboma. 61
25800772 2015
12
Posterior scleral reinforcement and vitrectomy for myopic foveoschisis in extreme myopia. 61
25111687 2015
13
Foxg1-Cre Mediated Lrp2 Inactivation in the Developing Mouse Neural Retina, Ciliary and Retinal Pigment Epithelia Models Congenital High Myopia. 61
26107939 2015
14
[Uveal schwannoma mimicking melanoma (case report)]. 61
24864500 2014
15
Intravitreal ranibizumab for the treatment of pathological myopia associated with choroidal neovascularization in Chinese patients. 61
25131225 2014
16
In vivo visualization of perforating vessels and focal scleral ectasia in pathological myopia. 61
24194186 2013
17
Scleral micro-RNA signatures in adult and fetal eyes. 61
24205357 2013
18
[Complications of deep nonpenetrating sclerectomy]. 61
23214459 2012
19
Large post-traumatic ciliary staphyloma--a simple, safe and successful management. 61
23360030 2012
20
Renal coloboma syndrome. 61
21654726 2011
21
The expanded spectrum of focal choroidal excavation. 61
21670327 2011
22
[Surgical treatment of a perforated scleral staphyloma in Wegener's granulomatosis]. 61
21328175 2011
23
Ocular rhinosporidiosis with staphyloma formation: a case with unusual features. 61
28539772 2011
24
Epidermal nevus syndrome associated with anterior scleral staphyloma and ectopic bone and cartilaginous intraocular tissue. 61
20151270 2010
25
Ophthalmic pathology of Nance-Horan syndrome: case report and review of the literature. 61
19941417 2009
26
Pars plana Baerveldt implantation for refractory childhood glaucomas. 61
19525734 2009
27
Bilateral staphylomas presenting as bitemporal hemianopia. 61
24299639 2007
28
Cannulation of the suprachoroidal space: a novel drug delivery methodology to the posterior segment. 61
16989764 2006
29
[A study on axis length measurement of high myopia with cataract]. 61
17162866 2005
30
Morning glory syndrome: clinical, computerized tomographic, and ultrasonographic findings. 61
16250218 2005
31
[A case report of injecting gentamicin intraocularly by mistake being misdiagnosed as central retinal artery occlusion]. 61
17165336 2005
32
Structural organization of choroidal colobomas of young and adult patients and mechanism of retinal detachment. 61
17057813 2005
33
Ocular manifestations and surgical management of lid coloboma in a Chinese infant with linear nevus sebaceous syndrome. 61
15478746 2004
34
Bilateral senile scleral plaques mimicking post-inflammatory scleral ectasia. 61
15132382 2004
35
Staphyloma in a cat. 61
12753608 2003
36
Congenital anterior scleral staphyloma in an otherwise normal eye. 61
12691236 2003
37
Presenting signs of retinoblastoma in Congolese patients. 61
12058485 2002
38
Scleral ectasia as a complication of deep sclerectomy. 61
10831914 2000
39
Conjunctival rhinosporidiosis associated with scleral melting and staphyloma formation: diagnosis and management. 61
10632005 2000
40
Congenital scleral staphyloma in a dog repaired with preserved homologous peritoneum. 61
11397279 2000
41
[Semi-annular pre-equatorial scleral ectasia in a patient with glaucoma and onchocerciasis]. 61
10609173 1999
42
[Diode laser cyclophotocoagulation of secondary glaucoma caused by anterior, necrotizing scleritis]. 61
9888136 1998
43
Complex limbal choristomas in linear nevus sebaceous syndrome. 61
9709758 1998
44
[Atypical constellation of findings in Schimmelpenning-Feuerstein-Mims syndrome--case report and overview]. 61
9782468 1998
45
[Treatment of scleral staphyloma by fixation of a fascial graft with Tissucol]. 61
9721486 1998
46
[Clinical observation of the pathological changes of axial length, corneal curvature and posterior segment wall of eyeball in eyes with high myopia]. 61
15508251 1996
47
Repair of a giant scleral ulcer with preserved sclera and tissue adhesive. 61
8976517 1996
48
Scleral ectasia in rhegmatogenous retinal detachment. 61
8872376 1996
49
[Pathogenesis of eso- and hypotropia in high myopia]. 61
8839343 1996
50
Preliminary findings of ophthalmological abnormalities in farmed halibut. 61
7571265 1995

Variations for Scleral Staphyloma

Expression for Scleral Staphyloma

Search GEO for disease gene expression data for Scleral Staphyloma.

Pathways for Scleral Staphyloma

GO Terms for Scleral Staphyloma

Biological processes related to Scleral Staphyloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 8.8 PAX2 CRYGA CRYAA

Molecular functions related to Scleral Staphyloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 8.62 CRYGA CRYAA

Sources for Scleral Staphyloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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