Scleral Staphyloma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Scleral Staphyloma

MalaCards integrated aliases for Scleral Staphyloma:

Name: Scleral Staphyloma ¹² ¹⁵ ⁷³

Scleral Ectasia ¹²

Classifications:

MalaCards categories:
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:11595

ICD10 ³³ H15.84

ICD9CM ³⁵ 379.11

SNOMED-CT ⁶⁸ 111534007

UMLS ⁷³ C0155359

Sources

Summaries for Scleral Staphyloma

MalaCards based summary : Scleral Staphyloma, also known as scleral ectasia, is related to papillorenal syndrome and retinal detachment. An important gene associated with Scleral Staphyloma is PAX2 (Paired Box 2), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Atracurium and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and bone, and related phenotypes are cardiovascular system and embryo

Sources

Related Diseases for Scleral Staphyloma

Diseases related to Scleral Staphyloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)

#	Related Disease	Score	Top Affiliating Genes
1	papillorenal syndrome	32.6	PAX2 PAX6
2	retinal detachment	10.3
3	retinitis	10.3
4	axenfeld-rieger syndrome, type 1	10.2	PAX2 PAX6
5	iris disease	10.2	OPTN PAX6
6	wilms tumor 5	10.1	PAX2 PAX6
7	marshall-smith syndrome	10.1	LRP2 OPTN
8	rhinosporidiosis	10.1
9	nevus, epidermal	9.9
10	choroiditis	9.9
11	ehlers-danlos syndrome	9.9
12	toxoplasmosis	9.9
13	juvenile glaucoma	9.9	OPTN PAX6
14	lens disease	9.8	OPTN PAX6
15	myopia	9.8
16	acanthamoeba keratitis	9.8
17	retinochoroidal coloboma	9.8
18	ectropion	9.8	NF1 PAX6
19	congenital aphakia	9.8	OPTN PAX2 PAX6
20	coloboma of macula	9.8	OPTN PAX2 PAX6
21	nephrogenic adenofibroma	9.8	NF1 PAX2
22	poland syndrome	9.7	NF1 PAX6
23	axenfeld-rieger syndrome	9.7	OPTN PAX6
24	hypotropia	9.6	NF1 OPTN
25	optic nerve neoplasm	9.6	NF1 OPTN
26	optic nerve glioma	9.5	NF1 OPTN
27	aniridia 1	9.5	OPTN PAX6
28	glaucoma 3, primary congenital, a	9.2	NF1 OPTN PAX6
29	trehalase deficiency	8.7	FOXG1 NF1 PAX2 PAX6

Graphical network of the top 20 diseases related to Scleral Staphyloma:

Sources

Symptoms & Phenotypes for Scleral Staphyloma

MGI Mouse Phenotypes related to Scleral Staphyloma:

⁴⁶ (show all 11)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.89	FOXG1 LRP2 NF1 PAX2 PAX6
2	embryo	MP:0005380	9.83	FOXG1 LRP2 NF1 PAX2 PAX6
3	endocrine/exocrine gland	MP:0005379	9.8	LRP2 NF1 PAX2 PAX6 FOXG1
4	mortality/aging	MP:0010768	9.8	LRP2 NF1 OPTN PAX2 PAX6 FOXG1
5	craniofacial	MP:0005382	9.78	FOXG1 LRP2 NF1 PAX6
6	hearing/vestibular/ear	MP:0005377	9.77	FOXG1 LRP2 NF1 PAX2 PAX6
7	digestive/alimentary	MP:0005381	9.76	FOXG1 LRP2 NF1 PAX6
8	renal/urinary system	MP:0005367	9.46	LRP2 NF1 PAX2 PAX6
9	pigmentation	MP:0001186	9.43	NF1 PAX2 PAX6
10	respiratory system	MP:0005388	9.26	FOXG1 LRP2 NF1 PAX6
11	vision/eye	MP:0005391	9.02	FOXG1 LRP2 NF1 PAX2 PAX6

Sources

Drugs & Therapeutics for Scleral Staphyloma

Drugs for Scleral Staphyloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Atracurium

Approved, Experimental, Investigational

Phase 4

64228-79-1

47319

Synonyms:

1-[(3,4-Dimethoxyphenyl)methyl]-2-[3-({5-[(3-{1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium-2-yl}propanoyl)oxy]pentyl}oxy)-3-oxopropyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium

2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium]

5-[3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate

64228-79-1

64228-81-5 (besylate)

AB00514743

AC1L2HUF

AC1Q67HR

Atracurium

Atracurium besilate

Atracurium besylate

Atracurium dibesylate

Atracurium Dibesylate

Besilate, atracurium

BPBio1_000011

BRN 1523633

BSPBio_000009

BW 33a

BW33a

BW-33a

C07548

C53H70N2O12

CHEBI:2914

CHEMBL1360

CID47319

DB00732

glaxo Wellcome brand OF atracurium besilate

HMS2090I21

LS-86151

MolPort-005-932-641

Pisa brand OF atracurium besilate

Prestwick1_000005

Prestwick2_000005

Prestwick3_000005

Relatrac

SPBio_001930

Tracrium

UNII-2GQ1IRY63P

Wellcome brand OF atracurium besilate

2

Bupivacaine

Approved, Investigational

Phase 4

2180-92-9, 38396-39-3

2474

Synonyms:

( inverted exclamation markA)-bupivacaine

(+-)-Bupivacaine

(±)-bupivacaine

(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

(RS)-bupivacaine

15233-43-9

1-Butyl-2',6'-pipecoloxylidide

1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide

1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

2180-92-9

38396-39-3

AB00053674

Abbott brand OF bupivacaine hydrochloride

AC1L1DRE

AC1Q5LX4

AC-2096

AH 250

AKOS001637202

Anekain

Anhydrous, bupivacaine

AR-1A0242

Astra brand OF bupivacaine hydrochloride

AstraZeneca brand OF bupivacaine hydrochloride

Aventis brand OF bupivacaine hydrochloride

Bio-0886

Bloqueina

BPBio1_000298

Braun brand OF bupivacaine hydrochloride

Braun, bupivacaina

BRD-A01636364-003-05-2

BSPBio_000270

BSPBio_002607

Bucaine

Bucaine (TN)

Bupivacain janapharm

Bupivacain RPR

Bupivacaina

Bupivacaina [INN-Spanish]

Bupivacaina braun

bupivacaine

Bupivacaine (INN)

Bupivacaine [INN:BAN]

Bupivacaine anhydrous

Bupivacaine carbonate

Bupivacaine Carbonate

Bupivacaine HCL

Bupivacaine HCL kit

Bupivacaine HCL KIT

Bupivacaine hydrochloride

Bupivacaine monohydrochloride, monohydrate

Bupivacaine Monohydrochloride, Monohydrate

Bupivacain-RPR

Bupivacainum

Bupivacainum [INN-Latin]

Bupivan

Buvacaina

C07529

C18H28N2O

Carbonate, bupivacaine

Carbostesin

cBupivacaine

CBupivacaine

CHEBI:3215

CHEMBL1098

CID2474

D07552

DB00297

DepoBupivacaine

DivK1c_000758

dl-1-Butyl-2',6'-pipecoloxylidide

DL-Bupivacaine

Dolanaest

DUR-843

EINECS 218-553-3

EINECS 253-911-2

HMS2090F12

Hydrochloride, bupivacaine

IDI1_000758

Inibsa brand OF bupivacaine hydrochloride

Janapharm, bupivacain

Jenapharm brand OF bupivacaine hydrochloride

KBio1_000758

KBio2_002004

KBio2_004572

KBio2_007140

KBio3_001827

KBioGR_001516

KBioSS_002004

KST-1A4609

L000695

LAC-43

LS-109841

LS-2222

Marcain

Marcaina

Marcaine

Marcaine HCL

Marcaine Spinal

MLS001361336

MolPort-004-955-820

NCGC00178579-01

NCGC00178579-02

NINDS_000758

NSC119660

Pisa brand OF bupivacaine hydrochloride

Prestwick0_000305

Prestwick1_000305

Prestwick2_000305

Prestwick3_000305

racemic bupivacaine

Sensorcaine

Sensorcaine-MPF

Sensorcaine-MPF Spinal

SMR000058218

SPBio_001558

SPBio_002489

Spectrum_001524

Spectrum2_001589

Spectrum3_000974

Spectrum4_001098

Spectrum5_001483

Strathmann brand OF bupivacaine hydrochloride

Svedocain sin vasoconstr

Transdur-Bupivacaine

UNII-Y8335394RO

Win 11318

Win 11318 HCl

3

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Synonyms:

.alpha.-(Diethylamino)-2,6-acetoxylidide

.alpha.-Diethylamino-2,6-dimethylacetanilide

.alpha.-Diethylaminoaceto-2,6-xylidide

.omega.-Diethylamino-2,6-dimethylacetanilide

137-58-6

2-(diethylamino)-2',6'-Acetoxylidide

2-(Diethylamino)-2',6'-acetoxylidide

2-(diethylamino)-N-(2,6-Dimethylphenyl)acetamide

2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide

2-2ETN-2MePhAcN

2-Diethylamino-N-(2,6-dimethylphenyl)acetamide

2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide

4-12-00-02538 (Beilstein Handbook Reference)

6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))

6108-05-0 (mono-hydrochloride, mono-hydrate)

73-78-9 (mono-hydrochloride)

AB00053581

AC-10282

AC1L1GGQ

AC1Q2Z7J

a-diethylamino-2,6-Dimethylacetanilide

After Burn Double Strength Gel

After Burn Double Strength Spray

After Burn Gel

After Burn Spray

AKOS001026768

alfa-Dietilamino-2,6-dimetilacetanilide

alfa-Dietilamino-2,6-dimetilacetanilide [Italian]

Alphacaine

alpha-diethylamino-2,6-dimethylacetanilide

alpha-diethylamino-2,6-Dimethylacetanilide

alpha-Diethylamino-2,6-dimethylacetanilide

Anestacon

Anestacon Jelly

ARONIS23855

Astrazeneca brand OF lidocaine

BIDD:GT0342

Bio-0767

Bio1_000379

Bio1_000868

Bio1_001357

Bio2_000079

Bio2_000559

BPBio1_000197

BRD-K52662033-001-02-6

BRD-K52662033-003-05-5

BRN 2215784

BSPBio_000179

BSPBio_001359

BSPBio_003004

C07073

C14H22N2O

Cappicaine

CAS-73-78-9

CDS1_000283

CHEBI:6456

CHEMBL79

CID3676

Cito optadren

CPD000058189

Cuivasil

D00358

Dalcaine

DB00281

Dentipatch

Dentipatch (TN)

DermaFlex

Diethylaminoaceto-2,6-xylidide

Dilocaine

DivK1c_000174

DivK1c_001323

Duncaine

EINECS 205-302-8

ELA-Max

EMBOLEX

Emla Cream

Esracaine

FT-0082378

Gravocain

HMS1791D21

HMS1989D21

HMS2051C21

HMS2089E15

HMS548M19

HSDB 3350

I01-2704

IDI1_000174

IDI1_033829

Isicaina

Isicaine

Jenapharm brand OF lidocanine hydrochloride

Jetocaine

KBio1_000174

KBio2_000079

KBio2_001598

KBio2_002647

KBio2_004166

KBio2_005215

KBio2_006734

KBio3_000157

KBio3_000158

KBio3_002224

KBioGR_000079

KBioGR_000599

KBioSS_000079

KBioSS_001598

L0156

L1026_SIGMA

L7757_SIGMA

Lanabiotic

L-Caine

Leostesin

Lida-Mantle

Lidocaina

Lidocaina [INN-Spanish]

lidocaine

LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)

Lidocaine (JP15/USP/INN)

Lidocaine (VAN)

Lidocaine [USAN:INN:JAN]

Lidocaine carbonate

Lidocaine Carbonate

Lidocaine carbonate (2:1)

Lidocaine hydrocarbonate

Lidocaine Hydrocarbonate

Lidocaine hydrochloride

Lidocaine monoacetate

Lidocaine monohydrochloride

Lidocaine Monohydrochloride

Lidocaine monohydrochloride, monohydrate

Lidocaine sulfate (1:1)

Lidocainum

Lidocainum [INN-Latin]

Lidocaton

Lidoderm

Lidoject-1

Lidoject-2

LIDOPEN

Lignocaine

Lignocainum

Lingocaine

Lopac0_000669

Lopac-L-5647

LQZ

LS-805

Maricaine

Maybridge1_002571

MLS000069724

MLS000758263

MLS001074177

MolPort-001-783-478

N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide

N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide

NCGC00015611-01

NCGC00015611-02

NCGC00015611-03

NCGC00015611-04

NCGC00015611-14

NCGC00022176-05

NCGC00022176-06

NCGC00022176-07

NCGC00022176-08

NCGC00022176-09

nchembio.65-comp16

NINDS_000174

Norwood Sunburn Spray

Novocol brand OF lidocaine hydrochloride

NSC 40030

NSC40030

Octocaine

Octocaine-100

Octocaine-50

Prestwick0_000050

Prestwick1_000050

Prestwick2_000050

Prestwick3_000050

Remicaine

Rocephin Kit

Rucaina

S1357_Selleck

SAM001247018

SMR000058189

Solarcaine aloe extra burn relief cream

Solcain

SPBio_001525

SPBio_002100

Spectrum_001118

Spectrum2_001343

Spectrum3_001392

Spectrum4_000070

Spectrum5_001549

STK552033

Strathmann brand OF lidocaine hydrochloride

UNII-98PI200987

WLN: 2N2 & 1VMR B1 F1

Xilina

Xilocaina

Xilocaina [Italian]

Xllina

Xycaine

Xylestesin

Xylesthesin

Xylocain

Xylocaine

Xylocaine (TN)

Xylocaine 5% Spinal

Xylocaine CO2

Xylocaine Dental Ointment

Xylocaine Endotracheal

Xylocaine Test Dose

Xylocaine Viscous

Xylocaine-Mpf

Xylocaine-Mpf with Glucose

Xylocard

Xylocitin

Xyloneural

Xyloneural (free base)

Xylotox

Zilactin-L

Zingo

α-diethylamino-2,6-dimethylacetanilide

4

Anesthetics

Phase 4

5

Anesthetics, Local

Phase 4

6

Anti-Arrhythmia Agents

Phase 4

7

Central Nervous System Depressants

Phase 4

8

Cholinergic Agents

Phase 4

9

Cholinergic Antagonists

Phase 4

10

Diuretics, Potassium Sparing

Phase 4

11

Neuromuscular Agents

Phase 4

12

Neuromuscular Blocking Agents

Phase 4

13

Neuromuscular Nondepolarizing Agents

Phase 4

14

Neurotransmitter Agents

Phase 4

15

Peripheral Nervous System Agents

Phase 4

16

Pharmaceutical Solutions

Phase 4

17

Sodium Channel Blockers

Phase 4

18

Menthol

Approved

Not Applicable

2216-51-5

16666

Synonyms:

(&#8722

(-)-(1R,3R,4S)-Menthol

(-)-menthol

()-Menthol

(-)-Menthyl alcohol

(-)-p-Menthan-3-ol

(-)-trans-p-Menthan-cis-ol

(-)-trans-P-Menthan-cis-ol

(+-)-(1R*,3R*,4S*)-Menthol

(+-)-Menthol

(+)-Neo-menthol

(+)-p-Menthan-3-ol

(+/-)-Menthol

(+/-)-p-Menthan-3-ol

(1a,2b,5a)-5-Methyl-2(1-methylethyl)cyclohexanol

(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol

(1R-(1-a,2-b,5-a))-5-Methyl-2-(1-methylethyl)cyclohexanol

(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol

(1R-(1-α,2-β,5-α))-5-methyl-2-(1-methylethyl)cyclohexanol

(1R)-(-)-Menthol

(1r,2s,5r)-(-)-menthol

(1R,2S,5R)-(-)-Menthol

(1R,2S,5R)-Menthol

(1R,3R,4S)-(-)-Menthol

(1R,3R,4S)-(-)-MENTHOL

(1S, 2S, 5R)-(+)-Neomenthol

(1S,2R,5R)-(+)-Isomenthol

(1S,2R,5S)-(+)-Menthol

(1S,2R,5S)-Menthol

(1α,2β,5α)-5-methyl-2(1-methylethyl)cyclohexanol

(L)-MENTHOL

(r)-(-)-menthol

(R)-(-)-Menthol

)-Menthol

1490-04-6

15356-60-2

15356-70-4

15785_RIEDEL

15785_SIAL

19863P

1-Menthol

20747-49-3

2216-51-5

2-Isopropyl-5-methylcyclohexanol

3-p-Menthol

491-02-1

4-Isopropyl-1-methylcyclohexan-3-ol

551376_ALDRICH

551376_FLUKA

588733_ALDRICH

5-Methyl-2-(1-methylethyl)cyclohexanol

5-Methyl-2-(1-methylethyl)-cyclohexanol

5-methyl-2-(propan-2-yl)cyclohexanol

5-methyl-2-propan-2-ylcyclohexan-1-ol

5-Methyl-2-propan-2-ylcyclohexan-1-ol

613290_ALDRICH

613290_FLUKA

63660_FLUKA

63670_ALDRICH

63670_FLUKA

63975-60-0

6C6A4A8C-A054-468C-A1F0-F29E39838CF2

89-78-1

98167-53-4

AC1L1B2E

AC1L28FR

AC1Q1NQ2

AC1Q2QQM

AI3-08161

AI3-52408

AKOS000119740

AR-1J3337

BB_NC-0057

BRN 1902288

BRN 3194263

BSPBio_003062

C00400

C10H20O

Caswell No. 540

CCRIS 3728

CCRIS 375

CCRIS 4666

CCRIS 9231

CHEBI:15409

CHEBI:545611

CHEMBL256087

CHEMBL470670

CID1254

CID16666

cis-1 ,3-trans-1,4-(+-)-menthol

cis-1,3-trans-1,4-(+-)-menthol

D-(-)-Menthol

d,l-Menthol

D00064

D008610

D04849

D04918

DB00825

DivK1c_000820

dl-3-p-Menthanol

dl-Menthol

dl-Menthol (JP15)

d-Menthol

d-Neomenthol

D-p-Menthan-3-ol

EINECS 201-939-0

EINECS 207-724-8

EINECS 216-074-4

EINECS 218-690-9

EINECS 239-387-8

EINECS 239-388-3

EPA Pesticide Chemical Code 051601

FEMA No. 2665

Fisherman's friend lozenges

Fisherman's friend lozenges (TN)

Headache crystals

Hexahydrothymol

HMS1922G13

HMS2092L14

HMS502I22

HSDB 5662

HSDB 593

I06-1216

I14-7371

IDI1_000820

KBio1_000820

KBio2_000785

KBio2_003353

KBio2_005921

KBio3_002562

KBioSS_000785

Kerasal

l-(-)-Menthol

L-(-)-menthol

L-(-)-Menthol

Levomenthol

Levomenthol [INN:BAN]

Levomentholum

Levomentholum [INN-Latin]

Levomentol

l-Menthol

L-menthol

L-Menthol

l-Menthol (JP15)

l-Menthol (natural)

l-Menthol (TN)

LMPR0102090001

LS-2353

LS-57201

LS-886

LS-89531

LS-89533

M0321

M0545

M2772_SIAL

Menthacamphor

MENTHOL

--MENTHOL

Menthol (USP)

Menthol (VAN)

Menthol natural

Menthol natural, brazilian

Menthol racemic

Menthol racemique

Menthol racemique [French]

Menthol solution

Menthol, (1alpha,2beta,5alpha)-isomer

Menthol, (1alpha,2beta,5alpha)-Isomer

Menthomenthol

Menthyl alcohol

MLS002207256

MolPort-000-849-729

MolPort-001-793-392

NCGC00159382-02

NCGC00159382-03

NCGC00164247-01

NCGC00164247-02

nchembio862-comp1

NCI-C50000

Neoisomenthol

NINDS_000820

NOOLISFMXDJSKH-KXUCPTDWBX

NSC 2603

NSC 62788

NSC2603

NSC62788

Peppermint camphor

p-Menthan-3-ol

P-Menthan-3-ol

Racementhol

Racementhol [INN:BAN]

Racementholum

Racementholum [INN-Latin]

Racementol

Racementol [INN-Spanish]

Racemic menthol

RACEMIC MENTHOL U.S.P.

rac-Menthol

Robitussin Cough Drops

SDCCGMLS-0066659.P001

SMR001306785

SPBio_000869

Spectrum_000305

SPECTRUM1503134

Spectrum2_000855

Spectrum3_001561

Spectrum5_001060

STK802468

Tra-kill tracheal mite killer

U.S.p. menthol

U.S.P. Menthol

UNII-BZ1R15MTK7

UNII-L7T10EIP3A

UNII-YS08XHA860

W266507_ALDRICH

W266523_ALDRICH

W266590_ALDRICH

WLN: L6TJ AY1&1 BQ D1

WLN: L6TJ AY1&1 DQ D1 -L

ZINC01482164

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy and Safety of Adding Atracurium to Percaruncular Block for High Myopes Undergoing Cataract Surgery	Completed	NCT03243500	Phase 4	Atracurium;Lidocaine 2%;Bupivacaine 0.5%;hyaluronidase powder
2	Macular Buckle With Three-armed Silicone	Completed	NCT02169635	Not Applicable
3	Vitrectomy and Scleral Shortening for Macular Hole Retinal Detachment or Myopic Traction Maculopathy	Completed	NCT02528045
4	Optical Coherence Tomography Imaging of the Posterior Segment in High Myopia.	Completed	NCT00347451
5	The Relationship Between Structure and Visual Function in Myopia Foveoschisis	Recruiting	NCT02915133

Search NIH Clinical Center for Scleral Staphyloma

Sources

Genetic Tests for Scleral Staphyloma

Sources

Anatomical Context for Scleral Staphyloma

MalaCards organs/tissues related to Scleral Staphyloma:

⁴¹

Eye, Brain, Bone

Sources

Publications for Scleral Staphyloma

Articles related to Scleral Staphyloma:

(show all 15)

#	Title	Authors	Year
1	Partial regression of large anterior scleral staphyloma secondary to rhinosporidiosis after corneoscleral graft - a case report. ( 29486755 )	Costa E.F....Silva G.E.B.	2018
2	The relationship between scleral staphyloma and choroidal thinning in highly myopic eyes: The Beijing Eye Study. ( 28852194 )	Zhou L.X....You Q.S.	2017
3	Secondary Bruch's membrane defects and scleral staphyloma in toxoplasmosis. ( 27040331 )	Jonas J.B....Panda-Jonas S.	2016
4	Epidermal nevus syndrome associated with anterior scleral staphyloma and ectopic bone and cartilaginous intraocular tissue. ( 20151270 )	Miyagawa Y....Kudoh T.	2010
5	Congenital anterior scleral staphyloma in an otherwise normal eye. ( 12691236 )	Shields J.A....Lavrich J.	2003
6	Congenital scleral staphyloma in a dog repaired with preserved homologous peritoneum. ( 11397279 )	Barros P.S....Safatle A.M.	2000
7	Anterior scleral staphyloma associated with neurofibromatosis. ( 1741610 )	Kremer I....Gaton D.D.	1991
8	Homograft of preserved sclera for post-traumatic scleral staphyloma in Ehlers-Danlos syndrome. ( 3710179 )	Nakazawa M....Watanabe Y.	1986
9	Retinal detachment and scleral staphyloma. ( 4453405 )	Delaney W.V.	1974
10	Ectopic brain tissue in a limbal dermoid associated with a scleral staphyloma. ( 4759859 )	Hutchison D.S....Iliff C.E.	1973
11	Rhinosporidiosis manifesting as an unusual scleral staphyloma. ( 5370824 )	Rao P.N....Ramalingam T.T.	1969
12	Equatorial scleral staphyloma; surgical treatment in a case with retinal detachment. ( 14388088 )	Young C.A.	1955
13	Scleral staphyloma and retinal detachment. ( 18135468 )	Vail D.	1949
14	Scleral Staphyloma and Retinal Detachment. ( 16693493 )	Vail D.	1948
15	Equatorial Scleral Staphyloma and Retinal Detachment Cured by Excision. ( 16693236 )	Vail D.	1940

Sources

Genes for Scleral Staphyloma

Genes related to Scleral Staphyloma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PAX2	Paired Box 2	Protein Coding	23.07	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
2	PAX6	Paired Box 6	Protein Coding	16.05	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	LRP2	LDL Receptor Related Protein 2	Protein Coding	14.96	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	OPTN	Optineurin	Protein Coding	14.47	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	FOXG1	Forkhead Box G1	Protein Coding	13.73	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	NF1	Neurofibromin 1	Protein Coding	13.67	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	MIR107	MicroRNA 107	RNA Gene	5.6	DISEASES inferred ¹⁵

Sources

Variations for Scleral Staphyloma

Sources

Expression for Scleral Staphyloma

Search GEO for disease gene expression data for Scleral Staphyloma.

Sources

Pathways for Scleral Staphyloma

Pathways related to Scleral Staphyloma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	10.52	PAX2 PAX6

Sources

GO Terms for Scleral Staphyloma

Biological processes related to Scleral Staphyloma according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	brain development	GO:0007420	9.5	FOXG1 NF1 PAX6
2	neural tube closure	GO:0001843	9.49	LRP2 PAX2
3	cerebral cortex development	GO:0021987	9.48	FOXG1 NF1
4	inner ear morphogenesis	GO:0042472	9.46	FOXG1 PAX2
5	camera-type eye development	GO:0043010	9.43	PAX2 PAX6
6	regulation of gene expression	GO:0010468	9.43	FOXG1 NF1 PAX6
7	negative regulation of neuron differentiation	GO:0045665	9.4	FOXG1 PAX6
8	dorsal/ventral pattern formation	GO:0009953	9.37	FOXG1 PAX6
9	positive regulation of neuroblast proliferation	GO:0002052	9.16	FOXG1 PAX6
10	cell fate determination	GO:0001709	8.96	PAX2 PAX6
11	forebrain development	GO:0030900	8.8	FOXG1 LRP2 PAX6

Sources

Sources for Scleral Staphyloma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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⁹ Cosmic

¹⁰ dbSNP

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¹² Disease Ontology

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¹⁶ DrugBank

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²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

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²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

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³⁰ HGMD

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³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

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⁴⁸ NCBI Bookshelf

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⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

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⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia