MCID: SCL014
MIFTS: 22

Scleral Staphyloma

Categories: Neuronal diseases

Aliases & Classifications for Scleral Staphyloma

MalaCards integrated aliases for Scleral Staphyloma:

Name: Scleral Staphyloma 12 15 70
Scleral Ectasia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11595
SNOMED-CT 67 111534007
UMLS 70 C0155359

Summaries for Scleral Staphyloma

MalaCards based summary : Scleral Staphyloma, also known as scleral ectasia, is related to papillorenal syndrome and retinal detachment. An important gene associated with Scleral Staphyloma is PAX2 (Paired Box 2). Affiliated tissues include eye and retina.

Related Diseases for Scleral Staphyloma

Diseases related to Scleral Staphyloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 papillorenal syndrome 32.1 PAX2 CRYAA
2 retinal detachment 10.4
3 rhinosporidiosis 10.1
4 herpes zoster 10.1
5 morgagni cataract 10.1 CRYGA CRYAA
6 ayme-gripp syndrome 10.1 CRYGA CRYAA
7 uveitis 10.1
8 cataract 24 10.1 CRYBB3 CRYAA
9 triosephosphate isomerase deficiency 10.0 CRYBB3 CRYAA
10 nevus, epidermal 10.0
11 strabismus 10.0
12 myopia 10.0
13 ehlers-danlos syndrome 10.0
14 scleritis 10.0
15 neurofibromatosis 10.0
16 mechanical strabismus 10.0
17 refractive error 10.0
18 toxoplasmosis 10.0
19 glioma 10.0
20 glial tumor 10.0
21 coloboma of macula 9.9
22 keratitis, hereditary 9.9
23 intraocular pressure quantitative trait locus 9.9
24 onchocerciasis 9.9
25 degenerative myopia 9.9
26 sclerosing keratitis 9.9
27 acanthamoeba keratitis 9.9
28 retinochoroidal coloboma 9.9
29 nance-horan syndrome 9.9 CRYBB3 CRYAA
30 cataract 32, multiple types 9.9 CRYBA1 CRYAA
31 early-onset lamellar cataract 9.9 CRYBA1 CRYAA
32 leukocoria 9.9 CRYBA1 CRYAA
33 abruzzo-erickson syndrome 9.9 CRYGA CRYBB3 CRYAA
34 porencephaly 9.9 CRYGA CRYBB3 CRYAA
35 cataract 11, multiple types 9.9 CRYBA1 CRYAA
36 aniridia 1 9.8 PAX2 CRYAA
37 cataract 31, multiple types 9.8 CRYBA1 CRYAA
38 cataract 16, multiple types 9.8 CRYBA1 CRYAA
39 night blindness, congenital stationary, type 2a 9.8 CRYBA1 CRYAA
40 persistent hyperplastic primary vitreous 9.7 PAX2 CRYBA1
41 posterior polar cataract 9.7 CRYGA CRYBA1 CRYAA
42 axenfeld-rieger syndrome, type 3 9.7 CRYGA CRYBA1 CRYAA
43 cataract 6, multiple types 9.6 CRYBB3 CRYBA1 CRYAA
44 early-onset nuclear cataract 9.6 CRYBB3 CRYBA1 CRYAA
45 erythrokeratodermia variabilis et progressiva 1 9.6 CRYBB3 CRYBA1 CRYAA
46 lens disease 9.6 CRYBB3 CRYBA1 CRYAA
47 nervous system disease 9.5 MIRLET7E MIR98 CRYAA
48 cataract 9.4 CRYGA CRYBB3 CRYBA1 CRYAA

Graphical network of the top 20 diseases related to Scleral Staphyloma:



Diseases related to Scleral Staphyloma

Symptoms & Phenotypes for Scleral Staphyloma

Drugs & Therapeutics for Scleral Staphyloma

Search Clinical Trials , NIH Clinical Center for Scleral Staphyloma

Genetic Tests for Scleral Staphyloma

Anatomical Context for Scleral Staphyloma

MalaCards organs/tissues related to Scleral Staphyloma:

40
Eye, Retina

Publications for Scleral Staphyloma

Articles related to Scleral Staphyloma:

(show top 50) (show all 84)
# Title Authors PMID Year
1
Progressive development of large choroidal excavation in neovascular age-related macular degeneration. 61
33325252 2020
2
Focal choroidal excavation: review of literature. 61
32788327 2020
3
RD repair using 360-degree scleral graft for extensive scleral ectasia in a patient with Ehlers Danlos syndrome. 61
32083221 2020
4
Bilateral Multiple Focal Choroidal Excavations in a Patient with Paroxysmal Nocturnal Hemoglobinuria (PNH). 61
31915557 2019
5
Macular Hole in Myopic Eyes: A Narrative Review of the Current Surgical Techniques. 61
30984418 2019
6
Partial regression of large anterior scleral staphyloma secondary to rhinosporidiosis after corneoscleral graft - a case report. 61
29486755 2018
7
Complications Assoicated with MIRAgel for Treatment of Retinal Detachment. 61
29144829 2018
8
[Clinical characteristics and surgical effect observation of congenital aniridia combined with cataract]. 61
29141386 2017
9
The relationship between scleral staphyloma and choroidal thinning in highly myopic eyes: The Beijing Eye Study. 61
28852194 2017
10
[Unilateral macular coloboma: about a case]. 61
29184607 2017
11
Secondary Bruch's membrane defects and scleral staphyloma in toxoplasmosis. 61
27040331 2016
12
Focal choroidal excavation: Clinical findings and complications. 61
26652731 2016
13
Spontaneous resealing of perforated scleral ectasia associated with atypical retinochoroidal coloboma. 61
25800772 2015
14
Posterior scleral reinforcement and vitrectomy for myopic foveoschisis in extreme myopia. 61
25111687 2015
15
Foxg1-Cre Mediated Lrp2 Inactivation in the Developing Mouse Neural Retina, Ciliary and Retinal Pigment Epithelia Models Congenital High Myopia. 61
26107939 2015
16
[Uveal schwannoma mimicking melanoma (case report)]. 61
24864500 2014
17
Intravitreal ranibizumab for the treatment of pathological myopia associated with choroidal neovascularization in Chinese patients. 61
25131225 2014
18
In vivo visualization of perforating vessels and focal scleral ectasia in pathological myopia. 61
24194186 2013
19
Scleral micro-RNA signatures in adult and fetal eyes. 61
24205357 2013
20
[Complications of deep nonpenetrating sclerectomy]. 61
23214459 2012
21
Large post-traumatic ciliary staphyloma--a simple, safe and successful management. 61
23360030 2012
22
Renal coloboma syndrome. 61
21654726 2011
23
The expanded spectrum of focal choroidal excavation. 61
21670327 2011
24
[Surgical treatment of a perforated scleral staphyloma in Wegener's granulomatosis]. 61
21328175 2011
25
Ocular rhinosporidiosis with staphyloma formation: a case with unusual features. 61
28539772 2011
26
Epidermal nevus syndrome associated with anterior scleral staphyloma and ectopic bone and cartilaginous intraocular tissue. 61
20151270 2010
27
Ophthalmic pathology of Nance-Horan syndrome: case report and review of the literature. 61
19941417 2009
28
Pars plana Baerveldt implantation for refractory childhood glaucomas. 61
19525734 2009
29
Bilateral staphylomas presenting as bitemporal hemianopia. 61
24299639 2007
30
Cannulation of the suprachoroidal space: a novel drug delivery methodology to the posterior segment. 61
16989764 2006
31
[A study on axis length measurement of high myopia with cataract]. 61
17162866 2005
32
Morning glory syndrome: clinical, computerized tomographic, and ultrasonographic findings. 61
16250218 2005
33
[A case report of injecting gentamicin intraocularly by mistake being misdiagnosed as central retinal artery occlusion]. 61
17165336 2005
34
Structural organization of choroidal colobomas of young and adult patients and mechanism of retinal detachment. 61
17057813 2005
35
Ocular manifestations and surgical management of lid coloboma in a Chinese infant with linear nevus sebaceous syndrome. 61
15478746 2004
36
Bilateral senile scleral plaques mimicking post-inflammatory scleral ectasia. 61
15132382 2004
37
Staphyloma in a cat. 61
12753608 2003
38
Congenital anterior scleral staphyloma in an otherwise normal eye. 61
12691236 2003
39
Presenting signs of retinoblastoma in Congolese patients. 61
12058485 2002
40
Scleral ectasia as a complication of deep sclerectomy. 61
10831914 2000
41
Congenital scleral staphyloma in a dog repaired with preserved homologous peritoneum. 61
11397279 2000
42
Conjunctival rhinosporidiosis associated with scleral melting and staphyloma formation: diagnosis and management. 61
10632005 2000
43
[Semi-annular pre-equatorial scleral ectasia in a patient with glaucoma and onchocerciasis]. 61
10609173 1999
44
[Diode laser cyclophotocoagulation of secondary glaucoma caused by anterior, necrotizing scleritis]. 61
9888136 1998
45
Complex limbal choristomas in linear nevus sebaceous syndrome. 61
9709758 1998
46
[Atypical constellation of findings in Schimmelpenning-Feuerstein-Mims syndrome--case report and overview]. 61
9782468 1998
47
[Treatment of scleral staphyloma by fixation of a fascial graft with Tissucol]. 61
9721486 1998
48
[Clinical observation of the pathological changes of axial length, corneal curvature and posterior segment wall of eyeball in eyes with high myopia]. 61
15508251 1996
49
Repair of a giant scleral ulcer with preserved sclera and tissue adhesive. 61
8976517 1996
50
Scleral ectasia in rhegmatogenous retinal detachment. 61
8872376 1996

Variations for Scleral Staphyloma

Expression for Scleral Staphyloma

Search GEO for disease gene expression data for Scleral Staphyloma.

Pathways for Scleral Staphyloma

GO Terms for Scleral Staphyloma

Biological processes related to Scleral Staphyloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of interleukin-6 production GO:0032715 9.4 MIRLET7E MIR98
2 cellular response to hydrogen peroxide GO:0070301 9.37 PAX2 MIR107
3 miRNA mediated inhibition of translation GO:0035278 9.33 MIRLET7E MIR98 MIR107
4 negative regulation of tyrosine phosphorylation of STAT protein GO:0042532 9.32 MIRLET7E MIR98
5 negative regulation of interleukin-6-mediated signaling pathway GO:0070104 9.26 MIRLET7E MIR98
6 lens development in camera-type eye GO:0002088 9.13 CRYGA CRYBB3 CRYBA1
7 visual perception GO:0007601 9.02 PAX2 CRYGA CRYBB3 CRYBA1 CRYAA

Molecular functions related to Scleral Staphyloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.13 MIRLET7E MIR98 MIR107
2 structural constituent of eye lens GO:0005212 8.92 CRYGA CRYBB3 CRYBA1 CRYAA

Sources for Scleral Staphyloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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