Aliases & Classifications for Scleral Staphyloma

MalaCards integrated aliases for Scleral Staphyloma:

Name: Scleral Staphyloma 12 15 73
Scleral Ectasia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11595
ICD10 33 H15.84
ICD9CM 35 379.11
SNOMED-CT 68 111534007
UMLS 73 C0155359

Summaries for Scleral Staphyloma

MalaCards based summary : Scleral Staphyloma, also known as scleral ectasia, is related to papillorenal syndrome and retinal detachment. An important gene associated with Scleral Staphyloma is PAX2 (Paired Box 2), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Atracurium and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and bone, and related phenotypes are cardiovascular system and embryo

Related Diseases for Scleral Staphyloma

Graphical network of the top 20 diseases related to Scleral Staphyloma:



Diseases related to Scleral Staphyloma

Symptoms & Phenotypes for Scleral Staphyloma

MGI Mouse Phenotypes related to Scleral Staphyloma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.89 FOXG1 LRP2 NF1 PAX2 PAX6
2 embryo MP:0005380 9.83 FOXG1 LRP2 NF1 PAX2 PAX6
3 endocrine/exocrine gland MP:0005379 9.8 LRP2 NF1 PAX2 PAX6 FOXG1
4 mortality/aging MP:0010768 9.8 LRP2 NF1 OPTN PAX2 PAX6 FOXG1
5 craniofacial MP:0005382 9.78 FOXG1 LRP2 NF1 PAX6
6 hearing/vestibular/ear MP:0005377 9.77 FOXG1 LRP2 NF1 PAX2 PAX6
7 digestive/alimentary MP:0005381 9.76 FOXG1 LRP2 NF1 PAX6
8 renal/urinary system MP:0005367 9.46 LRP2 NF1 PAX2 PAX6
9 pigmentation MP:0001186 9.43 NF1 PAX2 PAX6
10 respiratory system MP:0005388 9.26 FOXG1 LRP2 NF1 PAX6
11 vision/eye MP:0005391 9.02 FOXG1 LRP2 NF1 PAX2 PAX6

Drugs & Therapeutics for Scleral Staphyloma

Drugs for Scleral Staphyloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
2
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4 Anesthetics Phase 4
5 Anesthetics, Local Phase 4
6 Anti-Arrhythmia Agents Phase 4
7 Central Nervous System Depressants Phase 4
8 Cholinergic Agents Phase 4
9 Cholinergic Antagonists Phase 4
10 Diuretics, Potassium Sparing Phase 4
11 Neuromuscular Agents Phase 4
12 Neuromuscular Blocking Agents Phase 4
13 Neuromuscular Nondepolarizing Agents Phase 4
14 Neurotransmitter Agents Phase 4
15 Peripheral Nervous System Agents Phase 4
16 Pharmaceutical Solutions Phase 4
17 Sodium Channel Blockers Phase 4
18
Menthol Approved Not Applicable 2216-51-5 16666

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Adding Atracurium to Percaruncular Block for High Myopes Undergoing Cataract Surgery Completed NCT03243500 Phase 4 Atracurium;Lidocaine 2%;Bupivacaine 0.5%;hyaluronidase powder
2 Macular Buckle With Three-armed Silicone Completed NCT02169635 Not Applicable
3 Vitrectomy and Scleral Shortening for Macular Hole Retinal Detachment or Myopic Traction Maculopathy Completed NCT02528045
4 Optical Coherence Tomography Imaging of the Posterior Segment in High Myopia. Completed NCT00347451
5 The Relationship Between Structure and Visual Function in Myopia Foveoschisis Recruiting NCT02915133

Search NIH Clinical Center for Scleral Staphyloma

Genetic Tests for Scleral Staphyloma

Anatomical Context for Scleral Staphyloma

MalaCards organs/tissues related to Scleral Staphyloma:

41
Eye, Brain, Bone

Publications for Scleral Staphyloma

Articles related to Scleral Staphyloma:

(show all 15)
# Title Authors Year
1
Partial regression of large anterior scleral staphyloma secondary to rhinosporidiosis after corneoscleral graft - a case report. ( 29486755 )
2018
2
The relationship between scleral staphyloma and choroidal thinning in highly myopic eyes: The Beijing Eye Study. ( 28852194 )
2017
3
Secondary Bruch's membrane defects and scleral staphyloma in toxoplasmosis. ( 27040331 )
2016
4
Epidermal nevus syndrome associated with anterior scleral staphyloma and ectopic bone and cartilaginous intraocular tissue. ( 20151270 )
2010
5
Congenital anterior scleral staphyloma in an otherwise normal eye. ( 12691236 )
2003
6
Congenital scleral staphyloma in a dog repaired with preserved homologous peritoneum. ( 11397279 )
2000
7
Anterior scleral staphyloma associated with neurofibromatosis. ( 1741610 )
1991
8
Homograft of preserved sclera for post-traumatic scleral staphyloma in Ehlers-Danlos syndrome. ( 3710179 )
1986
9
Retinal detachment and scleral staphyloma. ( 4453405 )
1974
10
Ectopic brain tissue in a limbal dermoid associated with a scleral staphyloma. ( 4759859 )
1973
11
Rhinosporidiosis manifesting as an unusual scleral staphyloma. ( 5370824 )
1969
12
Equatorial scleral staphyloma; surgical treatment in a case with retinal detachment. ( 14388088 )
1955
13
Scleral staphyloma and retinal detachment. ( 18135468 )
1949
14
Scleral Staphyloma and Retinal Detachment. ( 16693493 )
1948
15
Equatorial Scleral Staphyloma and Retinal Detachment Cured by Excision. ( 16693236 )
1940

Variations for Scleral Staphyloma

Expression for Scleral Staphyloma

Search GEO for disease gene expression data for Scleral Staphyloma.

Pathways for Scleral Staphyloma

Pathways related to Scleral Staphyloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 PAX2 PAX6

GO Terms for Scleral Staphyloma

Biological processes related to Scleral Staphyloma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 brain development GO:0007420 9.5 FOXG1 NF1 PAX6
2 neural tube closure GO:0001843 9.49 LRP2 PAX2
3 cerebral cortex development GO:0021987 9.48 FOXG1 NF1
4 inner ear morphogenesis GO:0042472 9.46 FOXG1 PAX2
5 camera-type eye development GO:0043010 9.43 PAX2 PAX6
6 regulation of gene expression GO:0010468 9.43 FOXG1 NF1 PAX6
7 negative regulation of neuron differentiation GO:0045665 9.4 FOXG1 PAX6
8 dorsal/ventral pattern formation GO:0009953 9.37 FOXG1 PAX6
9 positive regulation of neuroblast proliferation GO:0002052 9.16 FOXG1 PAX6
10 cell fate determination GO:0001709 8.96 PAX2 PAX6
11 forebrain development GO:0030900 8.8 FOXG1 LRP2 PAX6

Sources for Scleral Staphyloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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