MCID: SCL022
MIFTS: 31

Scleredema

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Scleredema

MalaCards integrated aliases for Scleredema:

Name: Scleredema 54 60
Scleredema Adultorum 54 74
Scleredema Diabeticorum of Buschke 54
Scleredema Adultorum of Buschke 54
Scleredema Diabeticorum 54
Buschke's Scleredema 54
Buschke Scleredema 60

Characteristics:

Orphanet epidemiological data:

60
scleredema
Inheritance: Not applicable; Age of onset: Adolescent,Adult,Childhood,Infancy;

Classifications:

Orphanet: 60  
Rare skin diseases


External Ids:

ICD10 via Orphanet 35 M34.8
Orphanet 60 ORPHA352763
UMLS 74 C0036413

Summaries for Scleredema

NIH Rare Diseases : 54 Scleredema is a form of cutaneous mucinosis, a diverse group of rare skin conditions that are characterized by an accumulation of mucin (a jelly-like complex carbohydrate substance) in the skin. Signs and symptoms of this condition include hardening and thickening of the skin which may restrict movement. Skin in affected areas may be red or brown and often has an 'orange-skin' appearance. There are three forms of the condition which vary by disease course and long term outlook (prognosis). Although the underlying cause is currently unknown, each form is associated with a different condition: infection (type 1), blood abnormalities (type 2), and diabetes (type 3). In some cases, scleredema resolves spontaneously on its own, while in other affected people, the condition persists for long periods of time. Due to the rarity of the condition, there is no standard treatment.

MalaCards based summary : Scleredema, also known as scleredema adultorum, is related to scleredema adultorum and diabetes mellitus, and has symptoms including pruritus and exanthema. The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and heart.

Wikipedia : 77 Scleredema, is a rare, self-limiting skin condition defined by progressive thickening and hardening of... more...

Related Diseases for Scleredema

Graphical network of the top 20 diseases related to Scleredema:



Diseases related to Scleredema

Symptoms & Phenotypes for Scleredema

UMLS symptoms related to Scleredema:


pruritus, exanthema

Drugs & Therapeutics for Scleredema

Drugs for Scleredema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
2
tannic acid Approved Phase 3 1401-55-4
3
Histamine Approved, Investigational Early Phase 1 51-45-6 774
4
Calcium Approved, Nutraceutical Early Phase 1 7440-70-2 271
5
Tranilast Investigational Early Phase 1 53902-12-8 93543
6 Analgesics Early Phase 1
7 Neurotransmitter Agents Early Phase 1
8 Anti-Inflammatory Agents, Non-Steroidal Early Phase 1
9 Anti-Allergic Agents Early Phase 1
10 Calcium, Dietary Early Phase 1
11 Peripheral Nervous System Agents Early Phase 1
12 Histamine Antagonists Early Phase 1
13
Histamine Phosphate Early Phase 1 51-74-1 65513
14 calcium channel blockers Early Phase 1
15 Anti-Inflammatory Agents Early Phase 1
16 Histamine H1 Antagonists Early Phase 1
17 Antirheumatic Agents Early Phase 1
18 Hormones Early Phase 1
19 Platelet Aggregation Inhibitors Early Phase 1
20 Analgesics, Non-Narcotic Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Hypothermia to Treat Neonatal Hypoxic-Ischemic Encephalopathy Completed NCT00890409 Phase 3
2 A Clinical Study of Tranilast in the Treatment of Scleredema Diabeticorum Not yet recruiting NCT03512873 Early Phase 1 Tranilast

Search NIH Clinical Center for Scleredema

Genetic Tests for Scleredema

Anatomical Context for Scleredema

MalaCards organs/tissues related to Scleredema:

42
Skin, Testes, Heart, Pituitary

Publications for Scleredema

Articles related to Scleredema:

(show top 50) (show all 229)
# Title Authors Year
1
Scleredema diabeticorum: Description of 11 cases. ( 30717999 )
2019
2
Scleredema associated with immunoglobulin A-κ smoldering myeloma: a case report and review of the literature. ( 31084620 )
2019
3
Scleredema Diabeticorum with Superimposed Cellulitis and Abscess Formation. ( 29850291 )
2018
4
Scleredema of Buschke associated with lichen sclerosus: Three cases. ( 30289118 )
2018
5
Coexisting cutaneous macroglobulinosis and scleredema of Buschke in a patient with a Waldenström Macroglobulinemia. ( 30267590 )
2018
6
Implementation and evaluation of a rehabilitation concept in a patient suffering from Scleredema Adultorum Buschke: a case report. ( 28738698 )
2018
7
Serositis in a child with scleredema of Buschke: an unusual association and improvement following glucocorticoids. ( 28895446 )
2018
8
Paclitaxel-related scleredema-like skin changes in a patient with breast cancer. ( 28944958 )
2018
9
Letter on 'European dermatology forum S1-guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 2: Scleromyxedema, scleredema and nephrogenic systemic fibrosis'. ( 29283443 )
2018
10
Successful Treatment of Scleredema Diabeticorum With Tranilast: Three Case Reports. ( 29374068 )
2018
11
Ultrasonographic Findings of Scleredema Adultorum of Buschke Involving the Posterior Neck. ( 29713220 )
2018
12
European dermatology forum S1-guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 2: Scleromyxedema, scleredema and nephrogenic systemic fibrosis. ( 28786499 )
2017
13
Scleredema of Buschke with prominent periorbital edema. ( 28464273 )
2017
14
Successful treatment with IVIg therapy of diabetes-associated scleredema severe progressive case and review of the literature. ( 28573670 )
2017
15
A case of scleredema adultorum successfully treated with narrow-band ultraviolet B phototherapy. ( 24499427 )
2016
16
Scleredema adultorum of Buschke with prominent periorbital edema in a Tunisian patient with diabetes mellitus: a case report. ( 26536602 )
2016
17
Scleredema of Buschke associated with difficult-to-control type 2 diabetes mellitus. ( 27310540 )
2016
18
Laboratory Testing in the Setting of Diabetic Scleredema. ( 27483073 )
2016
19
Laboratory Testing in the Setting of Diabetic Scleredema--Reply. ( 27483076 )
2016
20
Atypical Scleredema Involving the Hands in an Adolescent. ( 27573162 )
2016
21
Scleredema of Buschke. ( 28149667 )
2016
22
Idiopathic scleredema. ( 28329532 )
2016
23
Long-term benefit of electron beam radiation therapy in the treatment of scleredema of Buschke. ( 28799569 )
2016
24
Detection of renal brush border membrane enzymes for evaluation of renal injury in neonatal scleredema. ( 25878616 )
2015
25
Scleredema of Buschke Following Streptococcal Infection. ( 26273177 )
2015
26
Scleredema. A multicentre study of characteristics, comorbidities, course and therapy in 44 patients. ( 26304054 )
2015
27
Scleredema associated with Sjögren's syndrome. ( 26312681 )
2015
28
Scleredema Diabeticorum - A Case Report. ( 26329963 )
2015
29
Therapy resistant idiopathic scleredema: an underlying pathology not always present. ( 27708956 )
2015
30
Paraproteinemia-associated scleredema treated successfully with intravenous immunoglobulin. ( 24847975 )
2014
31
Fulminans in dermatology: a call to action: a recommendation for consideration of the term scleredema fulminans. ( 25013539 )
2014
32
Extensive scleredema adultorum with loss of eccrine glands. ( 25128148 )
2014
33
Scleredema--an uncommon cause of swelling in a child--a case report and review of the literature. ( 25159854 )
2014
34
Improvement in clinical symptoms of scleredema diabeticorum by frequency-modulated electromagnetic neural stimulation: a case report. ( 25342834 )
2014
35
Scleredema adultorum of Buschke over an unusual site associated with pregnancy. ( 25396130 )
2014
36
Scleredema Adultorum of Buschke. ( 25823079 )
2014
37
Incomplete POEMS syndrome presenting for years solely with scleredema and hyperpigmentation. ( 23078370 )
2013
38
Complete remission of multiple myeloma associated scleredema after bortezomib-based treatment. ( 23061634 )
2013
39
Scleredema in a Patient with AIDS-Related Lipodystrophy Syndrome. ( 23365768 )
2013
40
Scleredema diabeticorum. ( 24365009 )
2013
41
Two cases of scleredema with pituitary-adrenocortical neoplasms: an underrecognized skin complication. ( 21463363 )
2012
42
Asymmetric childhood scleredema. ( 22123612 )
2012
43
Juvenile scleredema of Buschke. ( 22430703 )
2012
44
Scleredema adultorum of Buschke: with unusual manifestations in a young female. ( 22772630 )
2012
45
Successful treatment of poststreptococcal scleredema adultorum Buschke with intravenous immunoglobulins. ( 23069949 )
2012
46
Successful Treatment of Scleredema Diabeticorum by Combining Local PUVA and Colchicine: A Case Report. ( 23275772 )
2012
47
Scleredema diabeticorum partially treated with low-dose methotrexate: a report of five cases. ( 25207001 )
2012
48
Post-radiation scleredema adultorum and diffuse eosinophilic fasciitis in the same patient. ( 21077802 )
2011
49
Scleredema of Buschke following Mycoplasma pneumoniae respiratory infection. ( 21413959 )
2011
50
Case of diabetic scleredema: diagnostic value of magnetic resonance imaging. ( 21729146 )
2011

Variations for Scleredema

Expression for Scleredema

Search GEO for disease gene expression data for Scleredema.

Pathways for Scleredema

GO Terms for Scleredema

Sources for Scleredema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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