Aliases & Classifications for Scleredema Adultorum

MalaCards integrated aliases for Scleredema Adultorum:

Name: Scleredema Adultorum 12 44 15 73
Buschke's Scleredema 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3140
MeSH 44 D012592
NCIt 50 C85057
SNOMED-CT 68 72967001 95323007
UMLS 73 C0036413

Summaries for Scleredema Adultorum

MalaCards based summary : Scleredema Adultorum, also known as buschke's scleredema, is related to scleredema and diabetes mellitus, and has symptoms including pruritus and exanthema. An important gene associated with Scleredema Adultorum is FBN1 (Fibrillin 1), and among its related pathways/superpathways is G alpha (s) signalling events. The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and pituitary, and related phenotype is endocrine/exocrine gland.

Related Diseases for Scleredema Adultorum

Diseases related to Scleredema Adultorum via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 scleredema 12.4
2 diabetes mellitus 10.5
3 eosinophilic fasciitis 10.3
4 myeloma, multiple 10.3
5 fasciitis 10.3
6 diabetes mellitus, noninsulin-dependent 10.2
7 myositis 10.2
8 alopecia 10.2
9 primary hyperparathyroidism 10.2
10 hyperparathyroidism 10.2
11 purpura 10.2
12 cellulitis 10.2
13 carcinoid syndrome 10.2
14 opsoclonus-myoclonus syndrome 10.0 CXCL9 POMC
15 pituitary apoplexy 10.0 INS POMC
16 pancreatic endocrine carcinoma 10.0 INS POMC
17 noma 10.0 INS POMC
18 sheehan syndrome 10.0 INS POMC
19 hyperpituitarism 10.0 INS POMC
20 fetal erythroblastosis 10.0 INS POMC
21 pigmentation disease 10.0 INS POMC
22 sex differentiation disease 10.0 INS POMC
23 neurodermatitis 10.0 INS POMC
24 chromophobe adenoma 10.0 INS POMC
25 pituitary-dependent cushing's disease 10.0 INS POMC
26 orthostatic intolerance 10.0 FBN1 POMC
27 pituitary gland disease 10.0 INS POMC
28 pancreas disease 10.0 INS POMC
29 diabetes insipidus 10.0 INS POMC
30 hyperandrogenism 10.0 INS POMC
31 hypopituitarism 10.0 INS POMC
32 overnutrition 9.9 INS POMC
33 gonadal disease 9.9 INS POMC
34 glucose metabolism disease 9.9 INS POMC
35 acromegaly 9.9 INS POMC
36 aortic valve disease 1 9.9 FBN1 POMC
37 thyroid crisis 9.9 POMC PTH
38 cloacogenic carcinoma 9.9 POMC PTH
39 uremia 9.9 INS PTH
40 mineral metabolism disease 9.9 POMC PTH
41 multiple endocrine neoplasia, type i 9.8 INS PTH
42 nephrolithiasis 9.8 INS PTH
43 restless legs syndrome 9.8 POMC PTH
44 endocrine organ benign neoplasm 9.7 INS POMC PTH
45 thyroid gland disease 9.7 INS POMC PTH
46 cell type benign neoplasm 9.7 INS POMC PTH
47 urinary system disease 9.7 INS POMC PTH
48 acquired metabolic disease 9.7 INS POMC PTH
49 chronic kidney failure 9.7 INS PTH
50 mucinoses 9.7 CXCL9 FBN1 INS POMC

Graphical network of the top 20 diseases related to Scleredema Adultorum:



Diseases related to Scleredema Adultorum

Symptoms & Phenotypes for Scleredema Adultorum

UMLS symptoms related to Scleredema Adultorum:


pruritus, exanthema

MGI Mouse Phenotypes related to Scleredema Adultorum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 8.92 FBN1 INS POMC PTH

Drugs & Therapeutics for Scleredema Adultorum

Drugs for Scleredema Adultorum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 tannic acid Approved Phase 3
2
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
3
Histamine Approved, Investigational Early Phase 1 51-45-6, 75614-87-8 774
4
Tranilast Investigational Early Phase 1 53902-12-8 93543
5 Anti-Allergic Agents Early Phase 1
6 calcium channel blockers Early Phase 1
7 Histamine H1 Antagonists Early Phase 1
8 Analgesics Early Phase 1
9 Histamine Antagonists Early Phase 1
10 Analgesics, Non-Narcotic Early Phase 1
11 Anti-Inflammatory Agents Early Phase 1
12
Histamine Phosphate Early Phase 1 51-74-1 65513
13 Platelet Aggregation Inhibitors Early Phase 1
14 Peripheral Nervous System Agents Early Phase 1
15 Anti-Inflammatory Agents, Non-Steroidal Early Phase 1
16 Neurotransmitter Agents Early Phase 1
17 Calcium, Dietary Early Phase 1
18 Antirheumatic Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Hypothermia to Treat Neonatal Hypoxic-Ischemic Encephalopathy Completed NCT00890409 Phase 3
2 A Clinical Study of Tranilast in the Treatment of Scleredema Diabeticorum Not yet recruiting NCT03512873 Early Phase 1 Tranilast

Search NIH Clinical Center for Scleredema Adultorum

Cochrane evidence based reviews: scleredema adultorum

Genetic Tests for Scleredema Adultorum

Anatomical Context for Scleredema Adultorum

MalaCards organs/tissues related to Scleredema Adultorum:

41
Skin, Kidney, Pituitary, Pancreas, Thyroid

Publications for Scleredema Adultorum

Articles related to Scleredema Adultorum:

(show top 50) (show all 72)
# Title Authors Year
1
Ultrasonographic Findings of Scleredema Adultorum of Buschke Involving the Posterior Neck. ( 29713220 )
2018
2
Implementation and evaluation of a rehabilitation concept in a patient suffering from Scleredema Adultorum Buschke: a case report. ( 28738698 )
2017
3
Scleredema adultorum of Buschke with prominent periorbital edema in a Tunisian patient with diabetes mellitus: a case report. ( 26536602 )
2015
4
Extensive scleredema adultorum with loss of eccrine glands. ( 25128148 )
2014
5
Scleredema adultorum of Buschke over an unusual site associated with pregnancy. ( 25396130 )
2014
6
Scleredema Adultorum of Buschke. ( 25823079 )
2014
7
A case of scleredema adultorum successfully treated with narrow-band ultraviolet B phototherapy. ( 24499427 )
2014
8
Scleredema adultorum of Buschke: with unusual manifestations in a young female. ( 22772630 )
2012
9
Successful treatment of poststreptococcal scleredema adultorum Buschke with intravenous immunoglobulins. ( 23069949 )
2012
10
Post-radiation scleredema adultorum and diffuse eosinophilic fasciitis in the same patient. ( 21077802 )
2011
11
Scleredema adultorum: quali-quantitative analysis of collagen fibers. ( 22080650 )
2011
12
Scleredema adultorum of Buschke associated with a carcinoid tumor. ( 19570093 )
2009
13
Scleredema adultorum treated with narrow-band ultraviolet B phototherapy. ( 17352728 )
2007
14
Scleredema adultorum associated with type 2 diabetes mellitus: a report of three cases. ( 17374001 )
2007
15
Scleredema adultorum of Buschke: an under recognized skin complication of diabetes. ( 17110904 )
2006
16
Scleredema adultorum of Buschke: a case report and review of the literature. ( 16765712 )
2006
17
Scleredema adultorum associated with hyperkeratosis. ( 15660895 )
2005
18
Scleredema adultorum of Buschke presenting as periorbital edema: a diagnostic challenge. ( 15692512 )
2005
19
Successful UVA1 phototherapy in a patient with scleredema adultorum. ( 15752291 )
2005
20
Radiotherapy of benign diseases-scleredema adultorum Buschke. ( 15592702 )
2004
21
Scleredema adultorum due to streptococcal infection. ( 12654080 )
2003
22
Scleredema adultorum of Buschke treated with radiation. ( 12810510 )
2003
23
Dermacase. Scleredema adultorum, or Bushke disease. ( 14526859 )
2003
24
Scleroderma-like syndrome in a child: eosinophilic fasciitis or scleredema adultorum? ( 10923227 )
2000
25
Cream PUVA therapy for scleredema adultorum. ( 10809880 )
2000
26
Scleredema adultorum. ( 11013472 )
2000
27
Scleredema adultorum of buschke associated with non-scarring alopecia of scalp. ( 20885036 )
1999
28
Bath-PUVA therapy in three patients with scleredema adultorum. ( 9486680 )
1998
29
A clinical observation of scleredema adultorum and its relationship to diabetes. ( 9563277 )
1998
30
Scleredema adultorum associated with anaphylactoid purpura. ( 9111834 )
1997
31
Nonpitting induration of the back. Scleredema adultorum of Buschke type III. ( 9158420 )
1997
32
Scleredema adultorum : Report of two cases. ( 20952951 )
1995
33
Scleredema adultorum: case report and demonstration of abnormal expression of extracellular matrix genes in skin fibroblasts in vivo and in vitro. ( 7662581 )
1995
34
Electron-beam therapy in scleredema adultorum with associated monoclonal hypergammaglobulinaemia. ( 8148285 )
1994
35
Scleredema adultorum associated with IgG-kappa multiple myeloma--a case report and review of the literature. ( 3149919 )
1988
36
Scleredema adultorum of Buschke and primary hyperparathyroidism. ( 2976405 )
1988
37
Cardiomyopathy and multiple myeloma. Complications of scleredema adultorum. ( 2449145 )
1988
38
Scleredema adultorum associated with a monoclonal gammopathy and generalized hyperpigmentation. ( 3579342 )
1987
39
Scleredema adultorum. ( 3450649 )
1987
40
Scleredema adultorum in a child. ( 3819623 )
1986
41
Scleredema adultorum associated with localized myositis. ( 6519952 )
1984
42
Scleredema adultorum. ( 6209231 )
1984
43
Scleredema adultorum. A case of the recurrent cellulitis syndrome. ( 6497422 )
1984
44
Scleredema adultorum and diabetes mellitus (scleredema diutinum). ( 6839537 )
1983
45
Scleredema adultorum of Buschke: a clinical, pathologic, and cell culture study of two patients. ( 6194294 )
1983
46
Scleredema adultorum: the surgical implications of a rare dermatologic disorder. ( 6867183 )
1983
47
Scleredema adultorum of Buschke with upper esophageal involvement. ( 7064968 )
1982
48
Scleredema adultorum. ( 7458362 )
1980
49
Histologic observations of pleomorphic corynebacterium-like microorganisms in diabetic scleredema adultorum. ( 7438779 )
1980
50
Scleredema adultorum: a case report. ( 546763 )
1979

Variations for Scleredema Adultorum

Expression for Scleredema Adultorum

Search GEO for disease gene expression data for Scleredema Adultorum.

Pathways for Scleredema Adultorum

Pathways related to Scleredema Adultorum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.79 POMC PTH

GO Terms for Scleredema Adultorum

Cellular components related to Scleredema Adultorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CXCL9 FBN1 INS POMC PTH
2 secretory granule lumen GO:0034774 9.16 INS POMC
3 extracellular space GO:0005615 9.02 CXCL9 FBN1 INS POMC PTH

Biological processes related to Scleredema Adultorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.62 CXCL9 INS POMC PTH
2 skeletal system development GO:0001501 9.43 FBN1 PTH
3 glucose homeostasis GO:0042593 9.4 INS POMC
4 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.37 CXCL9 PTH
5 positive regulation of glucose import GO:0046326 9.26 INS PTH
6 cell-cell signaling GO:0007267 9.26 CXCL9 INS POMC PTH
7 positive regulation of glycogen biosynthetic process GO:0045725 9.16 INS PTH
8 regulation of signaling receptor activity GO:0010469 9.02 CXCL9 FBN1 INS POMC PTH

Molecular functions related to Scleredema Adultorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 FBN1 INS POMC PTH

Sources for Scleredema Adultorum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
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45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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