Scleredema Adultorum disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SCL002 MIFTS: 45	Scleredema Adultorum Categories: Blood diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Scleredema Adultorum

MalaCards integrated aliases for Scleredema Adultorum:

Name: Scleredema Adultorum ¹² ²⁰ ⁴⁴ ¹⁵ ¹⁷ ⁷¹

Buschke's Scleredema ¹² ²⁰

Scleredema ²⁰ ⁵⁸

Scleredema Diabeticorum of Buschke ²⁰

Scleredema Adultorum of Buschke ²⁰

Scleredema Diabeticorum ²⁰

Buschke Scleredema ⁵⁸

Characteristics:

Orphanet epidemiological data:

⁵⁸

scleredema
Inheritance: Not applicable; Age of onset: Adolescent,Adult,Childhood,Infancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the musculoskeletal system and connective tissue

Systemic connective tissue disorders

Systemic sclerosis

Other forms of systemic sclerosis

Orphanet: ⁵⁸

Rare skin diseases

External Ids:

Disease Ontology ¹² DOID:3140

MeSH ⁴⁴ D012592

NCIt ⁵⁰ C85057

SNOMED-CT ⁶⁷ 72967001

ICD10 via Orphanet ³³ M34.8

Orphanet ⁵⁸ ORPHA352763

EFO ¹⁷ EFO_1000762

UMLS ⁷¹ C0036413

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Summaries for Scleredema Adultorum

GARD : ²⁰ Scleredema is a form of cutaneous mucinosis, a diverse group of rare skin conditions that are characterized by an accumulation of mucin (a jelly-like complex carbohydrate substance) in the skin. Signs and symptoms of this condition include hardening and thickening of the skin which may restrict movement. Skin in affected areas may be red or brown and often has an 'orange-skin' appearance. There are three forms of the condition which vary by disease course and long term outlook (prognosis). Although the underlying cause is currently unknown, each form is associated with a different condition: infection (type 1), blood abnormalities (type 2), and diabetes (type 3). In some cases, scleredema resolves spontaneously on its own, while in other affected people, the condition persists for long periods of time. Due to the rarity of the condition, there is no standard treatment.

MalaCards based summary : Scleredema Adultorum, also known as buschke's scleredema, is related to primary hyperparathyroidism and localized scleroderma, and has symptoms including skin hardening, pruritus and exanthema. An important gene associated with Scleredema Adultorum is CXCL9 (C-X-C Motif Chemokine Ligand 9), and among its related pathways/superpathways are Allograft rejection and NF-kappaB Signaling. The drugs Histamine and Tranilast have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and thyroid, and related phenotypes are cellular and hematopoietic system

Disease Ontology : ¹² A skin disease that is characterized by induration of the skin, especially of the neck and upper trunk, has symptom skin hardening or stiffening, and is associated with infections (especially streptococcal), hematologic malignancies, diabetes, and adverse drug reactions.

Wikipedia : ⁷⁴ Scleredema, is a rare, self-limiting skin condition defined by progressive thickening and hardening of... more...

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Related Diseases for Scleredema Adultorum

Diseases related to Scleredema Adultorum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)

#	Related Disease	Score	Top Affiliating Genes
1	primary hyperparathyroidism	30.3	PTH POMC INS
2	localized scleroderma	30.0	MMP1 DCN CD34
3	systemic scleroderma	29.9	INS FN1 FBN1 CD8A
4	myeloma, multiple	29.8	NCAM1 FN1 CD8A CD34
5	lymphadenitis	29.7	FAS CXCL9 CD8A
6	connective tissue disease	29.3	PTH FN1 FBN1 CD8A
7	vascular disease	29.2	PTH INS FN1 CD34
8	diabetes mellitus	28.9	PTH POMC MMP1 INS FAS CD34
9	peripheral nervous system disease	28.4	POMC NCAM1 INS FN1 CD8A CD34
10	skin disease	10.3
11	cervical incompetence	10.3	FN1 DCN
12	kidney hypertrophy	10.3	INS FN1
13	opsoclonus-myoclonus syndrome	10.3	POMC CXCL9
14	raynaud phenomenon	10.3
15	odontogenic myxoma	10.3	MMP1 DCN
16	acidophil adenoma	10.2	POMC INS
17	pituitary infarct	10.2	POMC INS
18	eosinophilic fasciitis	10.2
19	hyperparathyroidism	10.2
20	mucinoses	10.2
21	fasciitis	10.2
22	scleromyxedema	10.2
23	benign essential hypertension	10.2	POMC INS
24	tendinosis	10.2	MMP1 DCN
25	sheehan syndrome	10.2	POMC INS
26	ovarian serous adenofibroma	10.2	POMC NCAM1
27	hypothalamic disease	10.2	POMC INS
28	decubitus ulcer	10.2	INS FN1
29	olfactory nerve neoplasm	10.2	POMC NCAM1
30	neurotic disorder	10.2	POMC INS
31	neonatal marfan syndrome	10.2	FBN1 DCN
32	cranial nerve malignant neoplasm	10.2	POMC NCAM1
33	benign pleural mesothelioma	10.2	INS CD34
34	calciphylaxis	10.2	PTH FN1
35	retroperitoneal hemangiopericytoma	10.2	INS CD34
36	cranial nerve neoplasm	10.2	POMC NCAM1
37	conventional fibrosarcoma	10.2	FN1 CD34
38	pituitary apoplexy	10.2	POMC INS
39	pancreatic endocrine carcinoma	10.2	NCAM1 INS
40	glomangiosarcoma	10.2	NCAM1 CD34
41	empty sella syndrome	10.2	POMC INS
42	cutaneous ganglioneuroma	10.2	NCAM1 CD34
43	potter's syndrome	10.2	INS CD34
44	vulvar leiomyoma	10.2	NCAM1 CD34
45	chronic actinic dermatitis	10.2	MMP1 FBN1
46	hyperpituitarism	10.2	POMC INS
47	orbital cancer	10.2	NCAM1 CD34
48	progeroid syndrome	10.2	FBN1 DCN
49	nasal cavity benign neoplasm	10.2	NCAM1 CD34
50	prostate stromal sarcoma	10.2	NCAM1 CD34

Graphical network of the top 20 diseases related to Scleredema Adultorum:

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Symptoms & Phenotypes for Scleredema Adultorum

Symptoms:

¹²

• skin hardening

UMLS symptoms related to Scleredema Adultorum:

pruritus, exanthema

MGI Mouse Phenotypes related to Scleredema Adultorum:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.1	CD34 CD8A DCN FAS FBN1 FN1
2	hematopoietic system	MP:0005397	9.97	CD34 CD8A DCN FAS FBN1 FN1
3	immune system	MP:0005387	9.96	CD34 CD8A DCN FAS FBN1 FN1
4	endocrine/exocrine gland	MP:0005379	9.91	CD8A DCN FAS FBN1 INS POMC
5	integument	MP:0010771	9.76	CD34 CD8A DCN FAS FBN1 FN1
6	neoplasm	MP:0002006	9.43	CD34 DCN FAS FN1 MMP1 POMC
7	renal/urinary system	MP:0005367	9.1	CD8A DCN FAS FBN1 INS POMC

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Drugs & Therapeutics for Scleredema Adultorum

Drugs for Scleredema Adultorum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Histamine

Approved, Investigational

Early Phase 1

51-45-6, 75614-87-8

774

Synonyms:

.beta.-Imidazolyl-4-ethylamine

[3H]histamine

1avn

1H-Imidazole-4-ethanamine

1H-Imidazole-5-ethanamine

1qft

2-(1H-imidazol-4-yl)ethan-1-amine

2-(1H-Imidazol-4-yl)ethanamine

2-(1H-Imidazol-4-yl)ethylamine

2-(1H-imidazol-5-yl)ethanamine

2-(1H-Imidazol-5-yl)ethanamine

2-(1H-Imidazol-5-yl)ethylamine

2-(3H-Imidazol-4-yl)ethylamine

2-(3H-Imidazol-4-yl)-ethylamine

2-(4-Imidazolyl)ethanamine

2-(4-imidazolyl)ethylamine

2-(4-Imidazolyl)ethylamine

2-[4-Imidazolyl]ethylamine

2-Imidazol-4-ylethylamine

2-Imidazol-4-yl-ethylamine

4-(2-Aminoethyl)-1H-imidazole

4-(2-Aminoethyl)imidazole

4-imidazoleethylamine

4-Imidazoleethylamine

51-45-6

53290_FLUKA

5-imidazoleethylamine

5-Imidazoleethylamine

64422-25-9

924364-91-0

AC-13185

AC1L19ZT

AC1Q54BV

AC1Q54BW

AKOS000274386

ALBB-005968

BCBcMAP01_000250

beta-aminoethylglyoxaline

beta-Aminoethylglyoxaline

beta-aminoethylimidazole

beta-Aminoethylimidazole

beta-aminothethylglyoxaline

beta-Aminothethylglyoxaline

beta-Imidazolyl-4-ethylamine

b-Imidazolyl-4-ethylamine

Bio1_000487

Bio1_000976

Bio1_001465

Bio2_000389

Bio2_000869

bmse000744

BSPBio_001117

BSPBio_002124

C00388

CCRIS 6535

CHEBI:18295

CHEMBL90

CID774

D08040

DivK1c_000308

EINECS 200-100-6

Eramin

Ergamine

Ergotidine

F411C768-A159-4FC0-A195-291A08BB03AA

Free histamine

H7125_SIGMA

histamine

Histamine

Histamine (DCF)

Histamine [USAN]

Histamine Base

Histamine, Free Base

Histaminum

Histaminum (TN)

HMS1362G19

HMS1792G19

HMS1990G19

HSDB 3338

HSM

IDI1_000308

IDI1_002144

Imidazole-4-ethylamine

Istamina

Istamina [Italian]

KBio1_000308

KBio2_000457

KBio2_001325

KBio2_003025

KBio2_003893

KBio2_005593

KBio2_006461

KBio3_000853

KBio3_000854

KBio3_001344

KBioGR_000457

KBioGR_001580

KBioSS_000457

KBioSS_001325

L000292

L-histamine

Lopac0_000595

Lopac-H-7250

LS-75835

MLS000069447

MolPort-001-785-597

MolPort-002-042-264

NCGC00015513-01

NCGC00015513-08

NCGC00093371-02

NCGC00093371-03

NCGC00093371-04

NCGC00093371-05

nchembio.87-comp54

nchembio714-comp1

NINDS_000308

NSC 33792

NSC33792

SDCCGMLS-0066601.P001

SMP1_000151

SMR000059091

SPBio_000729

Spectrum_000845

Spectrum2_000665

Spectrum3_000452

Spectrum4_000960

Spectrum5_000796

ST073926

STK346752

STOCK5S-55669

Theramine

UNII-820484N8I3

WLN: T5M CNJ D2Z

ZERO/004089

β-Imidazolyl-4-ethylamine

Tranilast

Investigational

Early Phase 1

53902-12-8

93543

Synonyms:

,4&prime

2-((3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl)amino)benzoic acid

2-({(2E)-3-[3,4-bis(methyloxy)phenyl]prop-2-enoyl}amino)benzoic acid

2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid

2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino] benzoic acid

3,4-DAA

53902-12-8

AC1NQZP4

AC-940

AKOS002841076

BRD-K17849083-001-02-2

BSPBio_003561

C18H17NO5

CHEMBL415324

CID5282230

CPD000058373

D02027

D27

DB07615

-Dimethoxycinnamoyl)anthranilic Acid

EU-0101193

HMS2051F05

HMS2089L07

HMS2094I21

HSCI1_000076

Lopac0_001193

LS-37150

MK 341

MLS000028468

MLS000759509

MLS001065902

MLS001077269

MLS002207030

MolPort-000-375-102

N 5'

N-(3&prime

n-(3',4'-dimethoxycinnamoyl) anthranilic acid

N-(3,4-Dimethoxycinnamoyl)anthranilic acid

NCGC00018185-05

NCGC00018185-09

NCGC00021458-04

NCGC00021458-05

NCGC00021458-07

NU-3450

Rizaben

Rizaben (TN)

Rizaben, SB 252218, MK 341, Tranpro ,Tranilast

S1439_Selleck

SAM001246737

SB-252218

SBB052710

SMR000058373

SPECTRUM1505333

T 0318

T0318_SIGMA

tranilast

Tranilast

Tranilast (JAN/USAN/INN)

Tranilast [USAN:INN:JAN]

Tranilastum

Tranilastum [INN-Latin]

Anti-Inflammatory Agents

Early Phase 1

Analgesics, Non-Narcotic

Early Phase 1

Anti-Inflammatory Agents, Non-Steroidal

Early Phase 1

Platelet Aggregation Inhibitors

Early Phase 1

Hormones

Early Phase 1

Histamine Antagonists

Early Phase 1

Analgesics

Early Phase 1

Histamine Phosphate

Early Phase 1

51-74-1

65513

Synonyms:

1H-Imidazole-4-ethanamine, phosphate (1:2)

2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)

4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)

4-(2-Aminoethyl)imidazole di-acid phosphate

4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate

51-74-1

53623-99-7

74-56-6

AC1L23E4

CID65513

D04445

DB00667

EINECS 200-118-4

H0147

Histamine acid phosphate

Histamine biphosphate

Histamine dihydrogen phosphate

Histamine diphosphate

Histamine phosphate (1:2)

Histamine phosphate (TN)

Histamine phosphate (USP)

Histamine phosphate [USP]

Histamine positive

LS-78569

UNII-QWB37T4WZZ

Antirheumatic Agents

Early Phase 1

Neurotransmitter Agents

Early Phase 1

Anti-Allergic Agents

Early Phase 1

Histamine H1 Antagonists

Early Phase 1

Calcium, Dietary

Early Phase 1

calcium channel blockers

Early Phase 1

Calcium

Nutraceutical

Early Phase 1

7440-70-2

271

Synonyms:

Ca(2+)

Ca2+

Calcio

Calcium

Calcium element

CALCIUM ion

Calcium(2+)

Calcium, doubly charged positive ion

Calcium, elemental

Elemental calcium

Kalzium

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Clinical Study of Tranilast in the Treatment of Scleredema Diabeticorum	Unknown status	NCT03512873	Early Phase 1	Tranilast
2	Screening Patients With Diabetes Mellitus for the Presence of Scleredema Adultorum of Buschke and Characterize Clinical-laboratory Findings of the Newly Identified Cases: a Single-center, Prospective, Obsevational Study	Recruiting	NCT04335396

Search NIH Clinical Center for Scleredema Adultorum

Cochrane evidence based reviews: scleredema adultorum

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Genetic Tests for Scleredema Adultorum

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Anatomical Context for Scleredema Adultorum

MalaCards organs/tissues related to Scleredema Adultorum:

⁴⁰

Skin, Bone Marrow, Thyroid, Pituitary

Sources

Publications for Scleredema Adultorum

Articles related to Scleredema Adultorum:

(show top 50) (show all 409)

#	Title	Authors	PMID	Year
1	Usefulness of high-frequency Doppler ultrasound skin thickness measurement for disease staging and assessing treatment response in patients with scleredema: a case-control study. ⁶¹	Giavedoni P...Mascaro JM	33493571	2021
2	Unilateral Linear Induration of the Skin: A Case Report of an Unusual Presentation of Scleredema. ⁶¹	Muhaidat J...Alshiyab D	33488921	2020
3	Concurrent Scleredema and Pyoderma Gangrenosum: Case Report and Review of Comorbid Conditions. ⁶¹	Jacob JS...Cohen PR	33489598	2020
4	Diabetes-associated dermatological manifestations in primary care and their association with vascular complications. ⁶¹	Trihan JE...Frances P	33520817	2020
5	Hyaluronidase in Dermatology: Uses Beyond Hyaluronic Acid Fillers. ⁶¹	Searle T...Al-Niaimi F	33026763	2020
6	A case of paraproteinemia-associated scleredema successfully treated with thalidomide. ⁶¹	Barnes M...Barnes H	32995440	2020
7	Scleredema and nodal inflammatory pseudotumor: IgG4-related disease? ⁶¹	Rodenas-Herranz T...Ruiz-Villaverde R	32530044	2020
8	Scleredema of Buschke associated with lichen sclerosus: Three cases. ⁶¹	Venturi M...Rongioletti F	30289118	2020
9	Scleredema diabeticorum: Description of 11 cases. ⁶¹	Simo-Guerrero O...Gimenez-Perez G	30717999	2020
10	Sclerodermalike syndromes: Great imitators. ⁶¹	Varju C...Minier T	32513403	2020
11	Scleredema adultorum of Buschke treated by extracorporeal shock wave therapy. ⁶¹	Kim DH...Choi YS	31733081	2020
12	Scleredema in the setting of Rheumatoid Arthritis. ⁶¹	Hartley K...Wlodek C	31502275	2020
13	A case of concurrent systemic sclerosis and scleredema. ⁶¹	Mitchell DC...Richardson CT	31687459	2019
14	[Sclerosing skin diseases]. ⁶¹	Sticherling M	31292667	2019
15	Efficacy of vitamin E combined with heparin sodium cream in treatment of scleredema neonatorum. ⁶¹	He J...Li H	31355597	2019
16	A comparative study of thoracoscopic and open surgery of congenital diaphragmatic hernia in neonates. ⁶¹	Qin J...Ma D	31242917	2019
17	Scleredema associated with immunoglobulin A-κ smoldering myeloma: a case report and review of the literature. ⁶¹	Keragala BSDP...Gunasekera CN	31084620	2019
18	Intravenous immunoglobulin treatment: Where do dermatologists stand? ⁶¹	Emre S	30756448	2019
19	Reticular Erythematous Mucinosis: A Rare Cutaneous. ⁶¹	Almohssen AA...Schwartz RA	31032786	2019
20	Coexisting cutaneous macroglobulinosis and scleredema of Buschke in a patient with a Waldenström Macroglobulinemia. ⁶¹	Roupie AL...Harel S	30267590	2019
21	An Unusual Presentation of a Rare Scleroderma Mimic: What is Behind the Scenes? ⁶¹	Ibrahim RA...Mostafa NBH	30088450	2019
22	Youth-Onset Type 2 Diabetes Manifestations in other Specialties: Its Many Disguises. ⁶¹	Weghuber D...Kovarenko M	31096219	2019
23	Implementation and evaluation of a rehabilitation concept in a patient suffering from Scleredema Adultorum Buschke: a case report. ⁶¹	Mickel M...Crevenna R	28738698	2018
24	[Efficacy and safety of selective brain hypothermia therapy on neonatal hypoxic-ischemic encephalopathy]. ⁶¹	Chen X...Pan J	30541643	2018
25	[Scleredema adultorum : Clinical presentation, diagnostic workup, differential diagnosis, treatment option]. ⁶¹	Kreuter A	30128796	2018
26	Paclitaxel-related scleredema-like skin changes in a patient with breast cancer. ⁶¹	Tani N...Yamamoto O	28944958	2018
27	Serositis in a child with scleredema of Buschke: an unusual association and improvement following glucocorticoids. ⁶¹	Sharma D...Singh S	28895446	2018
28	Ultrasonographic Findings of Scleredema Adultorum of Buschke Involving the Posterior Neck. ⁶¹	Ha DH...Kim SJ	29713220	2018
29	[Buschke's scleredema successfully treated with extracorporeal photopheresis]. ⁶¹	Dezoteux F...Carpentier O	29544653	2018
30	Successful Treatment of Scleredema Diabeticorum With Tranilast: Three Case Reports. ⁶¹	Sun M...Hou M	29374068	2018
31	Scleroderma with an update about clinico-pathological correlation. ⁶¹	Rongioletti F...Soda G	29368844	2018
32	Scleroderma-like Disorders. ⁶¹	Sharma A	28606036	2018
33	Letter on 'European dermatology forum S1-guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 2: Scleromyxedema, scleredema and nephrogenic systemic fibrosis'. ⁶¹	Mark PB...Roditi G	29283443	2018
34	Anti-carbamylated protein antibodies and skin involvement in patients with systemic sclerosis: An intriguing association. ⁶¹	Favoino E...Perosa F	30596753	2018
35	Miscellaneous skin disease and the metabolic syndrome. ⁶¹	Seremet S...Gurel MS	29241760	2018
36	Scleredema Diabeticorum with Superimposed Cellulitis and Abscess Formation. ⁶¹	Shrestha B...Khalid M	29850291	2018
37	Cutaneous Manifestations of Scleroderma and Scleroderma-Like Disorders: a Comprehensive Review. ⁶¹	Ferreli C...Atzori L	28712039	2017
38	[SKIN PATHOLOGY IN DIABETES MELLITUS: CLINICAL AND PATHOPHYSIOLOGICAL CORRELATIONS (REVIEW)]. ⁶¹	Kochet K...Sulaieva O	29328028	2017
39	European dermatology forum S1-guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 2: Scleromyxedema, scleredema and nephrogenic systemic fibrosis. ⁶¹	Knobler R...Krieg T	28786499	2017
40	Scleredema of Buschke with prominent periorbital edema. ⁶¹	Fania L...Mazzanti C	28464273	2017
41	Cutaneous Manifestations of Diabetes Mellitus: A Review. ⁶¹	Lima AL...Elsner P	28374407	2017
42	Successful treatment with IVIg therapy of diabetes-associated scleredema severe progressive case and review of the literature. ⁶¹	Kennemer C...Sami N	28573670	2017
43	Pathophysiological Mechanisms in Sclerosing Skin Diseases. ⁶¹	Eckes B...Krieg T	28868289	2017
44	Scleredema of Buschke. ⁶¹	Namas R...Ashraf A	28149667	2016
45	Idiopathic scleredema. ⁶¹	Ng E...Pomeranz MK	28329532	2016
46	Atypical Scleredema Involving the Hands in an Adolescent. ⁶¹	Lewis CM...Davis LS	27573162	2016
47	Laboratory Testing in the Setting of Diabetic Scleredema--Reply. ⁶¹	Chatterjee S	27483076	2016
48	Laboratory Testing in the Setting of Diabetic Scleredema. ⁶¹	Alter D	27483073	2016
49	[Risk factors for concurrent sepsis in neonates with necrotizing enterocolitis]. ⁶¹	An Y...Li LQ	27530780	2016
50	Scleredema of Buschke associated with difficult-to-control type 2 diabetes mellitus. ⁶¹	Lemes LR...Vilar EA	27310540	2016

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Genes for Scleredema Adultorum

Genes related to Scleredema Adultorum (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CXCL9	C-X-C Motif Chemokine Ligand 9	Protein Coding	4.67	DISEASES inferred ¹⁵
2	FN1	Fibronectin 1	Protein Coding	4.63	DISEASES inferred ¹⁵
3	DCN	Decorin	Protein Coding	4.59	DISEASES inferred ¹⁵
4	INS	Insulin	Protein Coding	4.54	DISEASES inferred ¹⁵
5	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	4.16	DISEASES inferred ¹⁵
6	MMP1	Matrix Metallopeptidase 1	Protein Coding	4.04	DISEASES inferred ¹⁵
7	POMC	Proopiomelanocortin	Protein Coding	3.96	DISEASES inferred ¹⁵
8	PTH	Parathyroid Hormone	Protein Coding	3.8	DISEASES inferred ¹⁵
9	FBN1	Fibrillin 1	Protein Coding	3.7	DISEASES inferred ¹⁵
10	FAS	Fas Cell Surface Death Receptor	Protein Coding	3.33	DISEASES inferred ¹⁵
11	CD8A	CD8a Molecule	Protein Coding	3.32	DISEASES inferred ¹⁵
12	CD34	CD34 Molecule	Protein Coding	3.26	DISEASES inferred ¹⁵

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Variations for Scleredema Adultorum

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Expression for Scleredema Adultorum

Search GEO for disease gene expression data for Scleredema Adultorum.

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Pathways for Scleredema Adultorum

Pathways related to Scleredema Adultorum according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Allograft rejection ³⁶ ¹ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.52	INS FAS CXCL9 CD8A
2	NF-kappaB Signaling ⁴	12.14	NCAM1 FAS CD8A CD34
3	Degradation of the extracellular matrix ⁶⁵ Show member pathways Collagen degradation ⁶⁵ Extracellular matrix organization ⁶⁵	12.01	NCAM1 MMP1 FN1 FBN1 DCN
4	Cell adhesion molecules ³⁶	11.81	NCAM1 CD8A CD34
5	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.64	NCAM1 CD8A CD34
6	Interleukin-4 and 13 signaling ⁶⁵	11.6	POMC MMP1 FN1
7	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.34	NCAM1 CD8A CD34
8	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.2	NCAM1 CD8A CD34
9	Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.08	PTH NCAM1 INS FN1 DCN CD34
10	Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics ⁶⁰	10.73	POMC INS

Sources

GO Terms for Scleredema Adultorum

Cellular components related to Scleredema Adultorum according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.7	PTH POMC INS FN1 FBN1 DCN
2	collagen-containing extracellular matrix	GO:0062023	9.62	NCAM1 FN1 FBN1 DCN
3	extracellular matrix	GO:0031012	9.56	MMP1 FN1 FBN1 DCN
4	extracellular region	GO:0005576	9.4	PTH POMC NCAM1 MMP1 INS FN1
5	external side of plasma membrane	GO:0009897	9.35	NCAM1 FAS CXCL9 CD8A CD34

Biological processes related to Scleredema Adultorum according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	leukocyte migration	GO:0050900	9.58	MMP1 FN1 CD34
2	wound healing	GO:0042060	9.5	INS FN1 DCN
3	extracellular matrix organization	GO:0030198	9.46	MMP1 FN1 FBN1 DCN
4	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.43	INS FN1 DCN
5	positive regulation of glycogen biosynthetic process	GO:0045725	9.37	PTH INS
6	cell-cell signaling	GO:0007267	9.26	PTH POMC INS CXCL9
7	cellular protein metabolic process	GO:0044267	8.92	MMP1 INS FN1 FBN1

Molecular functions related to Scleredema Adultorum according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	8.92	PTH POMC INS FBN1

Sources

Sources for Scleredema Adultorum

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia