Aliases & Classifications for Scleredema Adultorum

MalaCards integrated aliases for Scleredema Adultorum:

Name: Scleredema Adultorum 12 45 15 17 74
Buschke's Scleredema 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3140
MeSH 45 D012592
NCIt 51 C85057
SNOMED-CT 69 72967001 95323007
UMLS 74 C0036413

Summaries for Scleredema Adultorum

Disease Ontology : 12 A skin disease that is characterized by induration of the skin, especially of the neck and upper trunk, has symptom skin hardening or stiffening, and is associated with infections (especially streptococcal), hematologic malignancies, diabetes, and adverse drug reactions.

MalaCards based summary : Scleredema Adultorum, also known as buschke's scleredema, is related to scleredema and diabetes mellitus, and has symptoms including skin hardening or stiffening, pruritus and exanthema. An important gene associated with Scleredema Adultorum is FN1 (Fibronectin 1), and among its related pathways/superpathways are Signaling by GPCR and G alpha (s) signalling events. The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, pituitary and thyroid.

Related Diseases for Scleredema Adultorum

Diseases related to Scleredema Adultorum via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 scleredema 12.1
2 diabetes mellitus 10.6
3 eosinophilic fasciitis 10.4
4 myeloma, multiple 10.4
5 fasciitis 10.4
6 rere-related disorders 10.3
7 myositis 10.2
8 alopecia 10.2
9 systemic scleroderma 10.2
10 primary hyperparathyroidism 10.2
11 hyperparathyroidism 10.2
12 purpura 10.2
13 cellulitis 10.2
14 carcinoid syndrome 10.2
15 non-secretory myeloma 10.1 CXCL9 FN1
16 opsoclonus-myoclonus syndrome 10.0 CXCL9 POMC
17 pituitary apoplexy 10.0 INS POMC
18 pancreatic endocrine carcinoma 10.0 INS POMC
19 noma 10.0 INS POMC
20 sheehan syndrome 10.0 INS POMC
21 hyperpituitarism 10.0 INS POMC
22 fetal erythroblastosis 10.0 INS POMC
23 neurodermatitis 10.0 INS POMC
24 chromophobe adenoma 10.0 INS POMC
25 pituitary-dependent cushing's disease 10.0 INS POMC
26 pituitary gland disease 10.0 INS POMC
27 pancreas disease 10.0 INS POMC
28 diabetes insipidus 9.9 INS POMC
29 hyperandrogenism 9.9 INS POMC
30 hypopituitarism 9.9 INS POMC
31 overnutrition 9.9 INS POMC
32 gonadal disease 9.9 INS POMC
33 glucose metabolism disease 9.9 INS POMC
34 end stage renal failure 9.8 FN1 PTH
35 acromegaly 9.8 INS POMC
36 thyroid crisis 9.8 POMC PTH
37 cloacogenic carcinoma 9.8 POMC PTH
38 mineral metabolism disease 9.8 POMC PTH
39 uremia 9.8 INS PTH
40 mucinoses 9.7 CXCL9 INS POMC
41 multiple endocrine neoplasia, type i 9.7 INS PTH
42 nephrolithiasis 9.6 INS PTH
43 endocrine organ benign neoplasm 9.5 INS POMC PTH
44 thyroid gland disease 9.5 INS POMC PTH
45 cell type benign neoplasm 9.5 INS POMC PTH
46 urinary system disease 9.5 INS POMC PTH
47 acquired metabolic disease 9.5 INS POMC PTH
48 chronic kidney failure 9.5 INS PTH

Graphical network of the top 20 diseases related to Scleredema Adultorum:



Diseases related to Scleredema Adultorum

Symptoms & Phenotypes for Scleredema Adultorum

Symptoms:

12
  • skin hardening or stiffening

UMLS symptoms related to Scleredema Adultorum:


pruritus, exanthema

Drugs & Therapeutics for Scleredema Adultorum

Drugs for Scleredema Adultorum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
2
tannic acid Approved Phase 3 1401-55-4
3
Histamine Approved, Investigational Early Phase 1 51-45-6 774
4
Calcium Approved, Nutraceutical Early Phase 1 7440-70-2 271
5
Tranilast Investigational Early Phase 1 53902-12-8 93543
6 Analgesics Early Phase 1
7 Neurotransmitter Agents Early Phase 1
8 Anti-Inflammatory Agents, Non-Steroidal Early Phase 1
9 Anti-Allergic Agents Early Phase 1
10 Calcium, Dietary Early Phase 1
11 Peripheral Nervous System Agents Early Phase 1
12 Histamine Antagonists Early Phase 1
13
Histamine Phosphate Early Phase 1 51-74-1 65513
14 calcium channel blockers Early Phase 1
15 Anti-Inflammatory Agents Early Phase 1
16 Histamine H1 Antagonists Early Phase 1
17 Antirheumatic Agents Early Phase 1
18 Hormones Early Phase 1
19 Platelet Aggregation Inhibitors Early Phase 1
20 Analgesics, Non-Narcotic Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Hypothermia to Treat Neonatal Hypoxic-Ischemic Encephalopathy Completed NCT00890409 Phase 3
2 A Clinical Study of Tranilast in the Treatment of Scleredema Diabeticorum Not yet recruiting NCT03512873 Early Phase 1 Tranilast

Search NIH Clinical Center for Scleredema Adultorum

Cochrane evidence based reviews: scleredema adultorum

Genetic Tests for Scleredema Adultorum

Anatomical Context for Scleredema Adultorum

MalaCards organs/tissues related to Scleredema Adultorum:

42
Skin, Pituitary, Thyroid, Heart, Kidney, Pancreas

Publications for Scleredema Adultorum

Articles related to Scleredema Adultorum:

(show top 50) (show all 76)
# Title Authors Year
1
Implementation and evaluation of a rehabilitation concept in a patient suffering from Scleredema Adultorum Buschke: a case report. ( 28738698 )
2018
2
Ultrasonographic Findings of Scleredema Adultorum of Buschke Involving the Posterior Neck. ( 29713220 )
2018
3
A case of scleredema adultorum successfully treated with narrow-band ultraviolet B phototherapy. ( 24499427 )
2016
4
Scleredema adultorum of Buschke with prominent periorbital edema in a Tunisian patient with diabetes mellitus: a case report. ( 26536602 )
2016
5
Extensive scleredema adultorum with loss of eccrine glands. ( 25128148 )
2014
6
Scleredema adultorum of Buschke over an unusual site associated with pregnancy. ( 25396130 )
2014
7
Scleredema Adultorum of Buschke. ( 25823079 )
2014
8
Scleredema adultorum of Buschke: with unusual manifestations in a young female. ( 22772630 )
2012
9
Successful treatment of poststreptococcal scleredema adultorum Buschke with intravenous immunoglobulins. ( 23069949 )
2012
10
Post-radiation scleredema adultorum and diffuse eosinophilic fasciitis in the same patient. ( 21077802 )
2011
11
Scleredema adultorum: quali-quantitative analysis of collagen fibers. ( 22080650 )
2011
12
Scleredema adultorum of Buschke associated with a carcinoid tumor. ( 19570093 )
2009
13
Scleredema adultorum treated with narrow-band ultraviolet B phototherapy. ( 17352728 )
2007
14
Scleredema adultorum associated with type 2 diabetes mellitus: a report of three cases. ( 17374001 )
2007
15
Scleredema adultorum of Buschke: a case report and review of the literature. ( 16765712 )
2006
16
Scleredema adultorum of Buschke: an under recognized skin complication of diabetes. ( 17110904 )
2006
17
Scleredema adultorum associated with hyperkeratosis. ( 15660895 )
2005
18
Scleredema adultorum of Buschke presenting as periorbital edema: a diagnostic challenge. ( 15692512 )
2005
19
Successful UVA1 phototherapy in a patient with scleredema adultorum. ( 15752291 )
2005
20
Buschke's scleredema and concomitant diseases: report of five cases and literature review. ( 16146615 )
2005
21
Radiotherapy of benign diseases-scleredema adultorum Buschke. ( 15592702 )
2004
22
Scleredema adultorum due to streptococcal infection. ( 12654080 )
2003
23
Scleredema adultorum of Buschke treated with radiation. ( 12810510 )
2003
24
Dermacase. Scleredema adultorum, or Bushke disease. ( 14526859 )
2003
25
Scleroderma-like syndrome in a child: eosinophilic fasciitis or scleredema adultorum? ( 10923227 )
2000
26
Cream PUVA therapy for scleredema adultorum. ( 10809880 )
2000
27
Scleredema adultorum. ( 11013472 )
2000
28
Scleredema adultorum of buschke associated with non-scarring alopecia of scalp. ( 20885036 )
1999
29
Bath-PUVA therapy in three patients with scleredema adultorum. ( 9486680 )
1998
30
A clinical observation of scleredema adultorum and its relationship to diabetes. ( 9563277 )
1998
31
Scleredema adultorum associated with anaphylactoid purpura. ( 9111834 )
1997
32
Nonpitting induration of the back. Scleredema adultorum of Buschke type III. ( 9158420 )
1997
33
Scleredema adultorum: case report and demonstration of abnormal expression of extracellular matrix genes in skin fibroblasts in vivo and in vitro. ( 7662581 )
1995
34
Scleredema adultorum : Report of two cases. ( 20952951 )
1995
35
Electron-beam therapy in scleredema adultorum with associated monoclonal hypergammaglobulinaemia. ( 8148285 )
1994
36
Cardiomyopathy and multiple myeloma. Complications of scleredema adultorum. ( 2449145 )
1988
37
Scleredema adultorum of Buschke and primary hyperparathyroidism. ( 2976405 )
1988
38
Scleredema adultorum associated with IgG-kappa multiple myeloma--a case report and review of the literature. ( 3149919 )
1988
39
Scleredema adultorum. ( 3450649 )
1987
40
Scleredema adultorum associated with a monoclonal gammopathy and generalized hyperpigmentation. ( 3579342 )
1987
41
Scleredema adultorum in a child. ( 3819623 )
1986
42
Scleredema adultorum. A case of the recurrent cellulitis syndrome. ( 6497422 )
1984
43
Scleredema adultorum. ( 6209231 )
1984
44
Scleredema adultorum associated with localized myositis. ( 6519952 )
1984
45
Scleredema adultorum of Buschke: a clinical, pathologic, and cell culture study of two patients. ( 6194294 )
1983
46
Buschke's scleredema with right-sided heart failure. Echocardiographic and clinical observations. ( 6673828 )
1983
47
Scleredema adultorum and diabetes mellitus (scleredema diutinum). ( 6839537 )
1983
48
Scleredema adultorum: the surgical implications of a rare dermatologic disorder. ( 6867183 )
1983
49
Scleredema adultorum of Buschke with upper esophageal involvement. ( 7064968 )
1982
50
Histologic observations of pleomorphic corynebacterium-like microorganisms in diabetic scleredema adultorum. ( 7438779 )
1980

Variations for Scleredema Adultorum

Expression for Scleredema Adultorum

Search GEO for disease gene expression data for Scleredema Adultorum.

Pathways for Scleredema Adultorum

Pathways related to Scleredema Adultorum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 CXCL9 FN1 INS POMC PTH
2 11.42 POMC PTH
3 11.01 FN1 POMC
4 10.65 FN1 INS

GO Terms for Scleredema Adultorum

Cellular components related to Scleredema Adultorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CXCL9 FN1 INS POMC PTH
2 secretory granule lumen GO:0034774 9.16 INS POMC
3 extracellular space GO:0005615 9.02 CXCL9 FN1 INS POMC PTH

Biological processes related to Scleredema Adultorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.67 CXCL9 INS POMC PTH
2 glucose homeostasis GO:0042593 9.46 INS POMC
3 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.43 CXCL9 PTH
4 wound healing GO:0042060 9.4 FN1 INS
5 acute-phase response GO:0006953 9.32 FN1 INS
6 positive regulation of glucose import GO:0046326 9.26 INS PTH
7 regulation of signaling receptor activity GO:0010469 9.26 CXCL9 INS POMC PTH
8 positive regulation of glycogen biosynthetic process GO:0045725 9.16 INS PTH
9 cell-cell signaling GO:0007267 8.92 CXCL9 INS POMC PTH

Molecular functions related to Scleredema Adultorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.96 FN1 INS
2 hormone activity GO:0005179 8.8 INS POMC PTH

Sources for Scleredema Adultorum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
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43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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