Aliases & Classifications for Scleredema Adultorum

MalaCards integrated aliases for Scleredema Adultorum:

Name: Scleredema Adultorum 12 44 15 73
Buschke's Scleredema 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3140
MeSH 44 D012592
NCIt 50 C85057
SNOMED-CT 68 72967001 95323007
UMLS 73 C0036413

Summaries for Scleredema Adultorum

MalaCards based summary : Scleredema Adultorum, also known as buschke's scleredema, is related to scleredema and diabetes mellitus, and has symptoms including exanthema and pruritus. An important gene associated with Scleredema Adultorum is FBN1 (Fibrillin 1). The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are cellular and hematopoietic system

Related Diseases for Scleredema Adultorum

Diseases related to Scleredema Adultorum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 scleredema 12.3
2 diabetes mellitus 10.4
3 pituitary apoplexy 10.3 INS POMC
4 sheehan syndrome 10.3 INS POMC
5 hyperpituitarism 10.3 INS POMC
6 fetal erythroblastosis 10.3 INS POMC
7 noma 10.2 INS POMC
8 sex differentiation disease 10.2 INS POMC
9 chromophobe adenoma 10.2 INS POMC
10 endocrine pancreas disease 10.2 INS POMC
11 pituitary-dependent cushing's disease 10.2 INS POMC
12 opsoclonus-myoclonus syndrome 10.2 CXCL9 POMC
13 eosinophilic fasciitis 10.2
14 myeloma, multiple 10.2
15 fasciitis 10.2
16 endogenous depression 10.2 INS POMC
17 aortic valve disease 1 10.2 FBN1 POMC
18 pancreas disease 10.2 INS POMC
19 pituitary gland disease 10.1 INS POMC
20 gonadal disease 10.1 INS POMC
21 female reproductive system disease 10.1 INS POMC
22 orthostatic intolerance 10.1 FBN1 POMC
23 thyroid crisis 10.1 POMC PTH
24 diabetes insipidus 10.1 INS POMC
25 hyperandrogenism 10.1 INS POMC
26 myositis 10.0
27 alopecia 10.0
28 primary hyperparathyroidism 10.0
29 esophagitis 10.0
30 hyperparathyroidism 10.0
31 purpura 10.0
32 cellulitis 10.0
33 carcinoid syndrome 10.0
34 cloacogenic carcinoma 10.0 POMC PTH
35 hypopituitarism 10.0 INS POMC
36 endocrine organ benign neoplasm 10.0 POMC PTH
37 mineral metabolism disease 10.0 POMC PTH
38 organ system benign neoplasm 10.0 POMC PTH
39 duodenitis 9.9 CD79A INS
40 overnutrition 9.9 INS POMC
41 subacute glomerulonephritis 9.9 CD79A POMC
42 glucose metabolism disease 9.9 INS POMC
43 uremia 9.8 INS PTH
44 non-secretory myeloma 9.8 CD79A CXCL9
45 mucinoses 9.8 CXCL9 FBN1 INS
46 pleuropneumonia 9.8 CD79A CXCL9
47 acromegaly 9.8 INS POMC
48 immunodeficiency with hyper-igm, type 2 9.8 CD79A CXCL9
49 vernal conjunctivitis 9.7 CD79A POMC
50 substernal goiter 9.7 CD79A PTH

Graphical network of the top 20 diseases related to Scleredema Adultorum:



Diseases related to Scleredema Adultorum

Symptoms & Phenotypes for Scleredema Adultorum

UMLS symptoms related to Scleredema Adultorum:


exanthema, pruritus

MGI Mouse Phenotypes related to Scleredema Adultorum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.72 CD79A FBN1 INS POMC PTH
2 hematopoietic system MP:0005397 9.65 CD79A FBN1 INS POMC PTH
3 immune system MP:0005387 9.55 PTH CD79A FBN1 INS POMC
4 no phenotypic analysis MP:0003012 9.26 CD79A FBN1 INS POMC
5 renal/urinary system MP:0005367 8.92 CD79A FBN1 INS POMC

Drugs & Therapeutics for Scleredema Adultorum

Drugs for Scleredema Adultorum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
2 tannic acid Approved, Nutraceutical Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Hypothermia to Treat Neonatal Hypoxic-Ischemic Encephalopathy Completed NCT00890409 Phase 3
2 A Clinical Study of Tranilast in the Treatment of Scleredema Diabeticorum Not yet recruiting NCT03512873 Early Phase 1 Tranilast

Search NIH Clinical Center for Scleredema Adultorum

Cochrane evidence based reviews: scleredema adultorum

Genetic Tests for Scleredema Adultorum

Anatomical Context for Scleredema Adultorum

MalaCards organs/tissues related to Scleredema Adultorum:

41
Skin

Publications for Scleredema Adultorum

Articles related to Scleredema Adultorum:

(show top 50) (show all 71)
# Title Authors Year
1
Ultrasonographic Findings of Scleredema Adultorum of Buschke Involving the Posterior Neck. ( 29713220 )
2018
2
Implementation and evaluation of a rehabilitation concept in a patient suffering from Scleredema Adultorum Buschke: a case report. ( 28738698 )
2017
3
Scleredema adultorum of Buschke with prominent periorbital edema in a Tunisian patient with diabetes mellitus: a case report. ( 26536602 )
2015
4
Extensive scleredema adultorum with loss of eccrine glands. ( 25128148 )
2014
5
Scleredema adultorum of Buschke over an unusual site associated with pregnancy. ( 25396130 )
2014
6
Scleredema Adultorum of Buschke. ( 25823079 )
2014
7
A case of scleredema adultorum successfully treated with narrow-band ultraviolet B phototherapy. ( 24499427 )
2014
8
Scleredema adultorum of Buschke: with unusual manifestations in a young female. ( 22772630 )
2012
9
Successful treatment of poststreptococcal scleredema adultorum Buschke with intravenous immunoglobulins. ( 23069949 )
2012
10
Post-radiation scleredema adultorum and diffuse eosinophilic fasciitis in the same patient. ( 21077802 )
2011
11
Scleredema adultorum: quali-quantitative analysis of collagen fibers. ( 22080650 )
2011
12
Scleredema adultorum of Buschke associated with a carcinoid tumor. ( 19570093 )
2009
13
Scleredema adultorum treated with narrow-band ultraviolet B phototherapy. ( 17352728 )
2007
14
Scleredema adultorum associated with type 2 diabetes mellitus: a report of three cases. ( 17374001 )
2007
15
Scleredema adultorum of Buschke: an under recognized skin complication of diabetes. ( 17110904 )
2006
16
Scleredema adultorum of Buschke: a case report and review of the literature. ( 16765712 )
2006
17
Scleredema adultorum associated with hyperkeratosis. ( 15660895 )
2005
18
Scleredema adultorum of Buschke presenting as periorbital edema: a diagnostic challenge. ( 15692512 )
2005
19
Successful UVA1 phototherapy in a patient with scleredema adultorum. ( 15752291 )
2005
20
Radiotherapy of benign diseases-scleredema adultorum Buschke. ( 15592702 )
2004
21
Scleredema adultorum due to streptococcal infection. ( 12654080 )
2003
22
Scleredema adultorum of Buschke treated with radiation. ( 12810510 )
2003
23
Dermacase. Scleredema adultorum, or Bushke disease. ( 14526859 )
2003
24
Scleroderma-like syndrome in a child: eosinophilic fasciitis or scleredema adultorum? ( 10923227 )
2000
25
Cream PUVA therapy for scleredema adultorum. ( 10809880 )
2000
26
Scleredema adultorum. ( 11013472 )
2000
27
Scleredema adultorum of buschke associated with non-scarring alopecia of scalp. ( 20885036 )
1999
28
Bath-PUVA therapy in three patients with scleredema adultorum. ( 9486680 )
1998
29
A clinical observation of scleredema adultorum and its relationship to diabetes. ( 9563277 )
1998
30
Scleredema adultorum associated with anaphylactoid purpura. ( 9111834 )
1997
31
Nonpitting induration of the back. Scleredema adultorum of Buschke type III. ( 9158420 )
1997
32
Scleredema adultorum : Report of two cases. ( 20952951 )
1995
33
Scleredema adultorum: case report and demonstration of abnormal expression of extracellular matrix genes in skin fibroblasts in vivo and in vitro. ( 7662581 )
1995
34
Electron-beam therapy in scleredema adultorum with associated monoclonal hypergammaglobulinaemia. ( 8148285 )
1994
35
Scleredema adultorum associated with IgG-kappa multiple myeloma--a case report and review of the literature. ( 3149919 )
1988
36
Scleredema adultorum of Buschke and primary hyperparathyroidism. ( 2976405 )
1988
37
Cardiomyopathy and multiple myeloma. Complications of scleredema adultorum. ( 2449145 )
1988
38
Scleredema adultorum associated with a monoclonal gammopathy and generalized hyperpigmentation. ( 3579342 )
1987
39
Scleredema adultorum. ( 3450649 )
1987
40
Scleredema adultorum in a child. ( 3819623 )
1986
41
Scleredema adultorum associated with localized myositis. ( 6519952 )
1984
42
Scleredema adultorum. ( 6209231 )
1984
43
Scleredema adultorum. A case of the recurrent cellulitis syndrome. ( 6497422 )
1984
44
Scleredema adultorum and diabetes mellitus (scleredema diutinum). ( 6839537 )
1983
45
Scleredema adultorum of Buschke: a clinical, pathologic, and cell culture study of two patients. ( 6194294 )
1983
46
Scleredema adultorum: the surgical implications of a rare dermatologic disorder. ( 6867183 )
1983
47
Scleredema adultorum of Buschke with upper esophageal involvement. ( 7064968 )
1982
48
Scleredema adultorum. ( 7458362 )
1980
49
Histologic observations of pleomorphic corynebacterium-like microorganisms in diabetic scleredema adultorum. ( 7438779 )
1980
50
Scleredema adultorum: a case report. ( 546763 )
1979

Variations for Scleredema Adultorum

Expression for Scleredema Adultorum

Search GEO for disease gene expression data for Scleredema Adultorum.

Pathways for Scleredema Adultorum

GO Terms for Scleredema Adultorum

Cellular components related to Scleredema Adultorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CXCL9 FBN1 INS POMC PTH
2 secretory granule lumen GO:0034774 9.16 INS POMC
3 extracellular space GO:0005615 9.02 CXCL9 FBN1 INS POMC PTH

Biological processes related to Scleredema Adultorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.62 CXCL9 INS POMC PTH
2 glucose homeostasis GO:0042593 9.4 INS POMC
3 response to nutrient levels GO:0031667 9.37 INS PTH
4 positive regulation of glucose import GO:0046326 9.26 INS PTH
5 cell-cell signaling GO:0007267 9.26 CXCL9 INS POMC PTH
6 positive regulation of glycogen biosynthetic process GO:0045725 9.16 INS PTH
7 regulation of signaling receptor activity GO:0010469 9.02 CXCL9 FBN1 INS POMC PTH

Molecular functions related to Scleredema Adultorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 FBN1 INS POMC PTH

Sources for Scleredema Adultorum

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17 ExPASy
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34 ICD10 via Orphanet
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
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74 UMLS via Orphanet
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