MCID: SCL015
MIFTS: 51

Scleritis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Scleritis

MalaCards integrated aliases for Scleritis:

Name: Scleritis 12 53 44 15 73

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:13452
ICD10 33 H15.0 H15.00
ICD9CM 35 379.00
MeSH 44 D015423
NCIt 50 C119046
SNOMED-CT 68 78370002
UMLS 73 C0036416

Summaries for Scleritis

MalaCards based summary : Scleritis is related to uveitis and cellulitis. An important gene associated with Scleritis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs beta-endorphin and Hormones have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and neutrophil, and related phenotypes are immune system and digestive/alimentary

Wikipedia : 76 Scleritis is a serious inflammatory disease that affects the white outer coating of the eye, known as... more...

Related Diseases for Scleritis

Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Scleritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 407)
# Related Disease Score Top Affiliating Genes
1 uveitis 30.4 CCL2 IFNG IL4 TNF
2 cellulitis 30.2 IL5 TNF
3 vasculitis 30.2 CCL2 SELE TNF
4 arthritis 30.0 CCL2 IFNG MMP9 TNF
5 conjunctivitis 29.9 IFNG IL4 IL5
6 stromal keratitis 29.8 CCL2 TNF
7 rheumatic heart disease 29.8 IL4 TNF
8 temporal arteritis 29.8 CCL2 IFNG TNF
9 churg-strauss syndrome 29.8 IL5 TNF
10 pneumonia 29.7 CCL2 IL5 TNF
11 lepromatous leprosy 29.7 IFNG TNF
12 pericarditis 29.7 IFNG TNF
13 colitis 29.6 IFNG IL4 TNF
14 rheumatoid arthritis 29.5 CCL2 IFNG IL4 MMP9 SELE TNF
15 toxic shock syndrome 29.4 IFNG IL4 TNF
16 toxoplasmosis 29.4 IFNG IL4 TNF
17 myasthenia gravis 29.4 IFNG IL4 TNF
18 mycobacterium tuberculosis 1 29.4 IFNG IL4 TNF
19 allergic conjunctivitis 29.3 IFNG IL4 IL5
20 takayasu arteritis 29.3 MMP9 SELE TNF
21 neuritis 29.2 CCL2 IFNG IL4 TNF
22 chronic conjunctivitis 29.2 IL4 IL5
23 systemic lupus erythematosus 29.1 CCL2 IFNG IL4 SELE TNF
24 vascular disease 29.0 CCL2 MMP9 SELE TNF
25 autoimmune disease 28.9 CCL2 IFNG IL22 IL4 IL5 TNF
26 psoriasis 28.7 CCL2 IFNG IL22 IL4 SELE TNF
27 multiple sclerosis 28.5 CCL2 IFNG IL4 IL5 MMP9 TNF
28 inflammatory bowel disease 28.4 CCL2 IFNG IL22 IL4 IL5 SELE
29 posterior scleritis 12.3
30 anterior scleritis 12.3
31 brawny scleritis 12.2
32 scleroperikeratitis 11.2
33 ischemic heart disease 10.2 CCL2 TNF
34 dengue shock syndrome 10.2 CCL2 TNF
35 chikungunya 10.2 CCL2 TNF
36 pyelonephritis 10.2 CCL2 TNF
37 complex regional pain syndrome 10.2 CCL2 TNF
38 viral encephalitis 10.2 CCL2 TNF
39 stachybotrys chartarum 10.2 CCL2 TNF
40 keratoconjunctivitis sicca 10.2 IL4 TNF
41 aphthous stomatitis 10.2 IL4 TNF
42 strabismus 10.2
43 bacterial sepsis 10.2 SELE TNF
44 cutaneous lupus erythematosus 10.2 SELE TNF
45 endometritis 10.2 SELE TNF
46 inclusion conjunctivitis 10.2 IL5 TNF
47 hypersensitivity reaction type iii disease 10.2 SELE TNF
48 localized scleroderma 10.2 SELE TNF
49 rheumatoid vasculitis 10.2 SELE TNF
50 tropical endomyocardial fibrosis 10.2 IL4 TNF

Comorbidity relations with Scleritis via Phenotypic Disease Network (PDN):


Rheumatoid Arthritis

Graphical network of the top 20 diseases related to Scleritis:



Diseases related to Scleritis

Symptoms & Phenotypes for Scleritis

MGI Mouse Phenotypes related to Scleritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.87 CCL2 IFNG IL4 IL5 MMP9 SELE
2 digestive/alimentary MP:0005381 9.77 IFNG IL4 IL5 MMP9 TNF
3 integument MP:0010771 9.65 IFNG IL4 MMP9 SELE TNF
4 liver/biliary system MP:0005370 9.55 IFNG IL4 IL5 SELE TNF
5 respiratory system MP:0005388 9.43 IFNG IL4 IL5 MMP9 SELE TNF
6 vision/eye MP:0005391 9.02 IFNG IL4 MMP9 SELE TNF

Drugs & Therapeutics for Scleritis

Drugs for Scleritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 beta-endorphin Phase 4,Phase 2
2 Hormones Phase 4,Phase 3,Phase 2,Phase 1
3 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
4 Adrenocorticotropic Hormone Phase 4,Phase 2
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
6 Melanocyte-Stimulating Hormones Phase 4,Phase 2
7
Infliximab Approved Phase 3,Phase 1 170277-31-3
8
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
9
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
10
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
11 Antirheumatic Agents Phase 3,Phase 1,Phase 2
12 Immunologic Factors Phase 3,Phase 1,Phase 2
13 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
14 Antineoplastic Agents, Hormonal Phase 3,Phase 1
15 glucocorticoids Phase 3,Phase 1
16 Anti-Inflammatory Agents Phase 3,Phase 1,Not Applicable
17 Gastrointestinal Agents Phase 3,Phase 1
18 Dermatologic Agents Phase 3,Phase 1
19 Antineoplastic Agents, Alkylating Phase 3
20 Alkylating Agents Phase 3
21
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
22
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
23
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 6436030 5284616
24
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
25
Tofacitinib Approved, Investigational Phase 2 477600-75-2
26 Pharmaceutical Solutions Phase 1, Phase 2
27 Ophthalmic Solutions Phase 1, Phase 2
28 Anti-Infective Agents Phase 1, Phase 2
29 Antibiotics, Antitubercular Phase 1, Phase 2
30 Anti-Bacterial Agents Phase 1, Phase 2
31 Antifungal Agents Phase 1, Phase 2
32 Antibodies Phase 1, Phase 2
33 Immunoglobulins Phase 1, Phase 2
34 Protein Kinase Inhibitors Phase 2
35 Antibodies, Monoclonal Phase 1, Phase 2
36 Neurotransmitter Agents Phase 2
37 Endorphins Phase 2
38
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
39
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
40 Peripheral Nervous System Agents Phase 1
41 Dexamethasone 21-phosphate Phase 1
42 HIV Protease Inhibitors Phase 1
43
protease inhibitors Phase 1
44 Autonomic Agents Phase 1
45 Antiemetics Phase 1
46 BB 1101 Phase 1
47
Mycophenolic acid Approved 24280-93-1 446541
48
Prednisolone Approved, Vet_approved 50-24-8 5755
49
Azathioprine Approved 446-86-6 2265
50
Etanercept Approved, Investigational 185243-69-0

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
2 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 3 Infliximab;Cyclophosphamide
3 Effects of Magnetic Therapy and Seawater Combined in Decreasing Intraocular Presion. Unknown status NCT02300818 Phase 1, Phase 2 Seawater eyedrops
4 Gevokizumab for Active Scleritis Completed NCT01835132 Phase 1, Phase 2
5 Sirolimus Injections for Autoimmune Scleritis Completed NCT01517074 Phase 1, Phase 2 Sirolimus
6 Rituximab in the Treatment of Scleritis and Non-Infectious Orbital Inflammation Completed NCT00415506 Phase 1, Phase 2 Rituximab
7 Tofacitinib for Inflammatory Eye Disease Recruiting NCT03580343 Phase 2 tofacitinib
8 Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma Active, not recruiting NCT01740297 Phase 1, Phase 2 Talimogene laherparepvec;Ipilimumab
9 A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis Not yet recruiting NCT03465111 Phase 2 ACTH (adrenocorticotropic hormone) gel
10 Iontophoresis Delivery of Dexamethasone Phosphate for Non-infectious, Non-necrotizing Anterior Scleritis, Phase 1 Dose-varying Study Completed NCT01059955 Phase 1 Dexamethasone Phosphate Ophthalmic Solution (EGP-437);Dexamethasone phosphate ophthalmic solution
11 Infliximab to Treat Non-Infectious Scleritis Completed NCT00075075 Phase 1 Infliximab
12 Study Evaluating PSI-697 in Patients With Scleritis Terminated NCT00367692 Phase 1 PSI-697
13 Causes of Visual Loss in Retinal Disease Unknown status NCT01613963 Immunosuppressive Agents
14 Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis Completed NCT01958567 Not Applicable
15 Perichondrium Autograft in Refractory Necrotizing Scleritis Completed NCT02864823 Not Applicable
16 Human Samples and Data Repository Completed NCT00539370
17 Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study Completed NCT00116090
18 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Not Applicable Anti-toxoplasmosis treatment;Anti-inflammatory treatments
19 Immune Responses to Antigens in Non-infectious Eye Inflammatory Diseases Completed NCT00357071
20 Influencing Factors in Uveitis Completed NCT00827086
21 LSFG-SKIN, Laser Speckle Flowgraphy Completed NCT03660618 Not Applicable
22 Comparison Between Sutureless and Glue Free Versus Sutured Limbal Conjunctival Autograft in Primary Pterygium Surgery Completed NCT02009072 Not Applicable
23 A Non-Interventional Study in Rheumatoid Arthritis Patients Treated With Tocilizumab (RoActemra/Actemra) Completed NCT01613378
24 Observational Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis Completed NCT01579006 Tocilizumab
25 Exploring Immune Cell Signatures in Autoimmunity and Dry Eye Syndrome Recruiting NCT02715323
26 Uveitis/Intraocular Inflammatory Disease Biobank (iBank) Recruiting NCT02656381
27 Ocular Manifestations in Rheumatic Diseases Active, not recruiting NCT03753893
28 A Comparison Between Surgical Techniques for Securing Conjunctival Autografting in Primary Pterygium Surgery Not yet recruiting NCT03301974 Not Applicable

Search NIH Clinical Center for Scleritis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: scleritis

Genetic Tests for Scleritis

Anatomical Context for Scleritis

MalaCards organs/tissues related to Scleritis:

41
Eye, T Cells, Neutrophil, Bone, Lung, Heart, B Cells

Publications for Scleritis

Articles related to Scleritis:

(show top 50) (show all 781)
# Title Authors Year
1
Posterior scleritis follow-up by Swept-Source optical coherence tomography. ( 29169639 )
2018
2
Pulmonary nodules and nodular scleritis in a teenager with superficial granulomatous pyoderma gangrenosum. ( 29243307 )
2018
3
Nocardial scleritis: A case report and a suggested algorithm for disease management based on a literature review. ( 29780901 )
2018
4
Cyclophosphamide or Rituximab Treatment of Scleritis and Uveitis for Patients with Granulomatosis with Polyangiitis. ( 29635229 )
2018
5
Scleral Patch Graft With a Suture Reinforcement Technique in Surgical Management of Necrotizing Scleritis With Ectasia. ( 29664747 )
2018
6
Infectious Scleritis: What the ID Clinician Should Know. ( 29977974 )
2018
7
Necrotising scleritis, keratitis and uveitis in primary antiphospholipid syndrome. ( 29764818 )
2018
8
Combined Tenonplasty and Scleral Graft for Refractory <i>Pseudomonas</i> Scleritis Following Pterygium Removal with Mitomycin C Application. ( 29719651 )
2018
9
Iontophoretic delivery of dexamethasone phosphate for non-infectious, non-necrotising anterior scleritis, dose-finding clinical trial. ( 29666122 )
2018
10
Clinical Profile of Scleritis in Children. ( 29370565 )
2018
11
A case of scleritis associated rheumatoid arthritis accompanying an intraocular elevated lesion. ( 29843653 )
2018
12
Scedosporium apiospermum infectious scleritis following posterior subtenon triamcinolone acetonide injection: a case report and literature review. ( 29433463 )
2018
13
Atypical posterior scleritis mimicking choroidal melanoma. ( 29738013 )
2018
14
Limbal Stem Cell Deficiency Secondary to Diffuse Non-necrotizing Anterior Scleritis: A Clinicopathological Report. ( 29794824 )
2018
15
Clinical Features of Scleritis Across the Asia-Pacific Region. ( 29953309 )
2018
16
Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis. ( 29511745 )
2018
17
Clinical characteristics and ocular complications of patients with scleritis in Japanese. ( 29796754 )
2018
18
Association of Low Vitamin D Levels with Noninfectious Uveitis and Scleritis. ( 29474126 )
2018
19
SjAPgren's Disease Associated with Severe Retinal Vasculitis and/or Necrotizing Scleritis: Two Cases. ( 29452446 )
2018
20
Scleritis ( 29763119 )
2018
21
Clinicopathological case: rapid cognitive decline and myoclonus associated with fever, arthropathy and scleritis. ( 30425126 )
2018
22
Scleritis, keratitis, and orbital cellulitis: isolated ocular manifestation of systemic lupus erythematosus. ( 30092731 )
2018
23
Successful management of bee sting induced Aspergillus fumigatus endophthalmitis and scleritis. ( 29480270 )
2018
24
Scleritis-associated vortex vein varix masquerading as choroidal melanoma. ( 30503012 )
2018
25
Scleritis in congenital erythropoietic porphyria - infective or inflammatory? ( 30249837 )
2018
26
Clinical profile of patients with posterior scleritis: A report from Eastern India. ( 30038152 )
2018
27
Commentary: Posterior scleritis: Nuances to discern and handle effectively! ( 30038153 )
2018
28
Isolation of acid from eye drop bottles being used by patients presenting with presumed scleritis. ( 30038147 )
2018
29
Bilateral Necrotizing Scleritis: A Deeper Look at a Vision-Threatening Illness. ( 30044263 )
2018
30
Necrotizing Scleritis After Cosmetic Conjunctivectomy With Mitomycin C. ( 30053476 )
2018
31
Tectonic corneal lamellar grafting for surgically-induced necrotizing scleritis after strabismus surgery: Case report & literature review. ( 30062145 )
2018
32
Dengue fever-associated necrotizing scleritis: A case report with long-term follow-up. ( 30095666 )
2018
33
Methotrexate for the treatment of noninfectious scleritis. ( 30119788 )
2018
34
Antineutrophil cytoplasmic antibody-positive scleritis: Clinical profile of patients from a tuberculosis-endemic region. ( 30355867 )
2018
35
Pattern of Scleritis in an Egyptian Cohort. ( 30412434 )
2018
36
Paradoxical Nodular Scleritis during Tocilizumab Therapy: A Case Report. ( 29093079 )
2017
37
Scleritis and Takayasu's disease - rare combined presentation. ( 29634707 )
2017
38
Necrobiotic xanthogranuloma scleritis in a case of granulomatosis with polyangiitis (Wegener's granulomatosis). ( 29042820 )
2017
39
Rituximab Induction and Maintenance Treatment in Patients with Scleritis and Granulomatosis with Polyangiitis (Wegener's). ( 28628344 )
2017
40
Successful treatment with tocilizumab for refractory scleritis associated with relapsing polychondritis. ( 28120637 )
2017
41
Hypertrophic Pachymeningitis Accompanying Scleritis. ( 28794383 )
2017
42
IgG4-related disease presenting as posterior scleritis and vitritis, progressing to multifocal orbital involvement. ( 28438752 )
2017
43
Conjunctival Necrosis Masquerading as Necrotizing Scleritis. ( 28910555 )
2017
44
Ocular metastasis from breast carcinoma simulating anterior scleritis: a case report. ( 28844204 )
2017
45
Interventions and Outcomes in Patients with Infectious Pseudomonas scleritis: A 10-Year Perspective. ( 29040032 )
2017
46
IgG4-related disease as an emerging cause of scleritis. ( 28229544 )
2017
47
Anakinra in the Treatment of Patients with Refractory Scleritis: A Pilot Study. ( 28537473 )
2017
48
Pseudomonas Scleritis following Pterygium Excision. ( 28924436 )
2017
49
Retinal and Choroidal Detachment in Antineutrophil Cytoplasmic Antibody-Associated Scleritis and Retinal Vasculitis Mimicking Choroidal Tumor. ( 28489623 )
2017
50
Ocular Pharmacology for Scleritis: Review of Treatment and a Practical Perspective. ( 28355124 )
2017

Variations for Scleritis

Expression for Scleritis

Search GEO for disease gene expression data for Scleritis.

Pathways for Scleritis

Pathways related to Scleritis according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 CCL2 IFNG IL22 IL4 IL5 MMP9
2
Show member pathways
13.51 CCL2 IFNG IL22 IL4 IL5 TNF
3
Show member pathways
13.38 CCL2 IFNG IL22 IL4 IL5 TNF
4
Show member pathways
13.25 CCL2 IL22 IL4 IL5 TNF
5
Show member pathways
13.18 CCL2 IFNG IL22 IL4 IL5 MMP9
6
Show member pathways
13.15 CCL2 IL22 IL4 IL5 TNF
7
Show member pathways
12.8 CCL2 MMP9 SELE TNF
8
Show member pathways
12.78 IFNG IL22 IL4 IL5 TNF
9 12.71 IFNG IL4 IL5 MMP9
10
Show member pathways
12.67 CCL2 IFNG IL4 TNF
11
Show member pathways
12.49 IFNG IL22 IL4 IL5 TNF
12 12.47 CCL2 IFNG IL4 TNF
13
Show member pathways
12.37 IFNG IL4 TNF
14
Show member pathways
12.36 IFNG IL4 IL5 TNF
15
Show member pathways
12.32 IFNG IL22 IL4 IL5
16
Show member pathways
12.27 CCL2 IFNG IL4 TNF
17
Show member pathways
12.17 IFNG IL4 IL5 TNF
18
Show member pathways
12.15 IFNG IL4 TNF
19
Show member pathways
12.09 IFNG IL4 TNF
20 12.09 IFNG MMP9 TNF
21
Show member pathways
12.07 CCL2 IFNG IL4 IL5 MMP9 TNF
22
Show member pathways
11.99 IFNG IL4 MMP9 TNF
23
Show member pathways
11.99 CCL2 IFNG IL22 IL4 IL5
24
Show member pathways
11.97 IFNG IL22 TNF
25 11.97 CCL2 IFNG MMP9 SELE TNF
26 11.94 IFNG IL4 IL5 TNF
27 11.93 CCL2 IL4 MMP9 TNF
28 11.89 CCL2 MMP9 SELE TNF
29 11.88 CCL2 IFNG IL4 MMP9 TNF
30 11.85 CCL2 SELE TNF
31 11.84 IL4 IL5 TNF
32 11.8 CCL2 IFNG TNF
33 11.75 IFNG IL4 IL5 SELE
34
Show member pathways
11.69 IFNG IL4 IL5 TNF
35 11.62 IFNG IL22 IL4 IL5 TNF
36
Show member pathways
11.6 IFNG MMP9 SELE TNF
37 11.51 CCL2 IL4 TNF
38 11.49 CCL2 IFNG TNF
39 11.47 IFNG IL4 IL5
40 11.45 CCL2 IFNG SELE TNF
41 11.4 CCL2 IFNG IL4 MMP9 TNF
42 11.37 IFNG TNF
43 11.34 IFNG SELE TNF
44 11.31 IFNG IL4 IL5
45 11.3 MMP9 SELE
46 11.24 CCL2 MMP9
47 11.21 CCL2 MMP9
48 11.2 IFNG IL4 IL5
49 11.17 CCL2 IFNG MMP9
50 11.15 CCL2 IL4 IL5 MMP9 TNF

GO Terms for Scleritis

Cellular components related to Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL2 IFNG IL22 IL4 IL5 MMP9
2 extracellular space GO:0005615 9.23 CCL2 IFNG IL22 IL4 IL5 MMP9

Biological processes related to Scleritis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.73 CCL2 IL5 TNF
2 leukocyte migration GO:0050900 9.71 MMP9 SELE TNF
3 positive regulation of protein phosphorylation GO:0001934 9.69 IFNG MMP9 TNF
4 immune response GO:0006955 9.65 CCL2 IFNG IL4 IL5 TNF
5 extrinsic apoptotic signaling pathway GO:0097191 9.6 IFNG TNF
6 positive regulation of nitric oxide biosynthetic process GO:0045429 9.59 IFNG TNF
7 positive regulation of B cell proliferation GO:0030890 9.58 IL4 IL5
8 protein kinase B signaling GO:0043491 9.58 CCL2 TNF
9 humoral immune response GO:0006959 9.58 CCL2 IFNG TNF
10 lipopolysaccharide-mediated signaling pathway GO:0031663 9.57 CCL2 TNF
11 positive regulation of protein complex assembly GO:0031334 9.55 IFNG TNF
12 inflammatory response GO:0006954 9.55 CCL2 IL22 IL5 SELE TNF
13 protein import into nucleus, translocation GO:0000060 9.52 IFNG TNF
14 positive regulation of osteoclast differentiation GO:0045672 9.49 IFNG TNF
15 leukocyte tethering or rolling GO:0050901 9.48 SELE TNF
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.46 IFNG TNF
17 positive regulation of podosome assembly GO:0071803 9.43 IL5 TNF
18 regulation of signaling receptor activity GO:0010469 9.43 CCL2 IFNG IL22 IL4 IL5 TNF
19 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IFNG TNF
20 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 IFNG TNF
21 cytokine-mediated signaling pathway GO:0019221 9.1 CCL2 IL22 IL4 IL5 MMP9 TNF

Molecular functions related to Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL2 IFNG IL22 IL4 IL5 TNF

Sources for Scleritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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