MCID: SCL015
MIFTS: 48

Scleritis

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Scleritis

MalaCards integrated aliases for Scleritis:

Name: Scleritis 12 52 43 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:13452
ICD9CM 34 379.00
MeSH 43 D015423
NCIt 49 C119046
SNOMED-CT 67 78370002
ICD10 32 H15.0
UMLS 71 C0036416

Summaries for Scleritis

MalaCards based summary : Scleritis is related to posterior scleritis and anterior scleritis. An important gene associated with Scleritis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ranibizumab and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include eye, neutrophil and t cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 74 Scleritis is a serious inflammatory disease that affects the white outer coating of the eye, known as... more...

Related Diseases for Scleritis

Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Scleritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 749)
# Related Disease Score Top Affiliating Genes
1 posterior scleritis 32.9 TNF PRTN3 MRAP CRP
2 anterior scleritis 31.4 TNFRSF1B PRTN3 MRAP IL1RN IL1RAPL2 CRP
3 retinal detachment 31.2 TNF MMP9 IFNG CCL2
4 microscopic polyangiitis 30.8 TNF CTLA4
5 macular retinal edema 30.7 TNF MRAP CCL2
6 uveitis 30.6 TNFRSF1B TNF IL4 IFNG CTLA4 CCL2
7 systemic autoimmune disease 30.5 MMP9 CRP
8 ocular tuberculosis 30.5 MRAP IFNG
9 lepromatous leprosy 30.4 TNF IL4 IFNG
10 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.4 PTPN22 IFNG CTLA4
11 toxoplasmosis 30.3 TNF IL5 IL4 IFNG
12 anca-associated vasculitis 30.3 PRTN3 CTLA4
13 relapsing polychondritis 30.3 IFNG CRP CCL2
14 eales disease 30.3 TNF IL4 IFNG
15 crohn's colitis 30.3 TNF IFNG CCR6
16 thyroiditis 30.2 TNF PTPN22 IL4 CTLA4
17 conjunctivitis 30.2 TNF MMP9 IL5 IL4 IFNG CCL2
18 neuritis 30.2 TNF MMP9 IL4 IFNG CCL2
19 intermediate uveitis 30.0 TNF MRAP IFNG CCR6
20 vitiligo-associated multiple autoimmune disease susceptibility 1 30.0 PTPN22 CTLA4 CCR6
21 allergic conjunctivitis 30.0 TNF IL5 IL4 IFNG
22 endophthalmitis 30.0 TNF SELE MRAP CRP
23 churg-strauss syndrome 29.9 TNF PRTN3 IL5
24 iridocyclitis 29.9 TNFRSF1B TNF MRAP CRP
25 chorioretinitis 29.8 TNFRSF1B TNF MRAP IFNG
26 choroiditis 29.8 TNFRSF1B TNF MRAP IFNG
27 pars planitis 29.8 MRAP IL1RN CCR6
28 blepharitis 29.8 TNF MMP9 IL4 CCR6
29 lyme disease 29.8 TNF MMP9 CRP
30 chronic conjunctivitis 29.8 TNF IL5 IL4 CCR6
31 leprosy 3 29.8 TNF IL5 IL4 IFNG CCR6
32 lupus erythematosus 29.8 TNFRSF1B TNF PTPN22 IFNG CTLA4
33 neuroretinitis 29.8 MRAP CRP
34 myasthenia gravis 29.7 TNF PTPN22 IL4 IFNG CTLA4
35 mumps 29.7 TNFRSF1B TNF IFNG
36 allergic hypersensitivity disease 29.6 TNF SELE IL5 IL4 IFNG CCR6
37 necrobiosis lipoidica 29.6 TNFRSF1B TNF
38 polyarteritis nodosa 29.6 SELE PRTN3 CRP
39 colitis 29.6 TNF IL4 IL22 IFNG CTLA4 CCR6
40 posterior uveitis 29.6 TNF MRAP IL5 IL4 IFNG CCR6
41 fibromyalgia 29.5 TNF CRP CCL2
42 histiocytosis 29.5 TNF IL1RN IFNG CCR6
43 antiphospholipid syndrome 29.5 TNF SELE CRP
44 retinal vasculitis 29.5 TNFRSF1B TNF MRAP CCR6 CCL2
45 hashimoto thyroiditis 29.4 TNF PTPN22 IL5 IL4 IFNG CTLA4
46 spondyloarthropathy 29.4 TNF SELE IL4 IFNG CCR6 CCL2
47 histoplasmosis 29.4 TNFRSF1B TNF IFNG CCR6
48 igg4-related disease 29.4 PRTN3 IL4 CRP CCR6
49 cryopyrin-associated periodic syndrome 29.4 IL1RN CRP
50 multiple cranial nerve palsy 29.4 PRTN3 CRP

Comorbidity relations with Scleritis via Phenotypic Disease Network (PDN):


Rheumatoid Arthritis

Graphical network of the top 20 diseases related to Scleritis:



Diseases related to Scleritis

Symptoms & Phenotypes for Scleritis

MGI Mouse Phenotypes related to Scleritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 CCR6 CTLA4 IFNG IL1RN IL22 IL4
2 homeostasis/metabolism MP:0005376 10.2 CCR6 CRP CTLA4 IFNG IL1RN IL22
3 cardiovascular system MP:0005385 10.17 CCR6 CRP CTLA4 IFNG IL1RN ITGB2
4 immune system MP:0005387 10.16 CCL2 CCR6 CRP CTLA4 IFNG IL1RN
5 digestive/alimentary MP:0005381 10.06 CTLA4 IFNG IL22 IL4 IL5 MMP9
6 integument MP:0010771 9.85 CTLA4 IFNG IL1RN IL22 IL4 ITGB2
7 liver/biliary system MP:0005370 9.65 CTLA4 IFNG IL22 IL4 IL5 MRAP
8 respiratory system MP:0005388 9.36 CTLA4 IFNG IL22 IL4 IL5 MMP9

Drugs & Therapeutics for Scleritis

Drugs for Scleritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4 347396-82-1 459903
2
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
3
Dipivefrin Approved Phase 4 52365-63-6 3105
4
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
5 Adrenocorticotropic Hormone Phase 4
6 Melanocyte-Stimulating Hormones Phase 4
7 beta-Endorphin Phase 4
8 Immunologic Factors Phase 4
9 Hormones Phase 4
10 Hormone Antagonists Phase 4
11 glucocorticoids Phase 4
12 Anti-Inflammatory Agents Phase 4
13 Immunosuppressive Agents Phase 4
14 Retinol palmitate Phase 4
15 Proxymetacaine Phase 4
16 retinol Phase 4
17 triamcinolone acetonide Phase 4
18 Anesthetics Phase 4
19 Triamcinolone diacetate Phase 4
20 Triamcinolone hexacetonide Phase 4
21
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
22
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
23
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
24
Infliximab Approved Phase 3 170277-31-3
25 Antirheumatic Agents Phase 3
26 Gastrointestinal Agents Phase 3
27 Alkylating Agents Phase 3
28 Dermatologic Agents Phase 3
29
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
30
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
31
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
32
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
33
Tofacitinib Approved, Investigational Phase 2 477600-75-2
34 Antineoplastic Agents, Immunological Phase 1, Phase 2
35 Anti-Bacterial Agents Phase 1, Phase 2
36 Antifungal Agents Phase 1, Phase 2
37 Antibiotics, Antitubercular Phase 1, Phase 2
38 Endorphins Phase 2
39 Neurotransmitter Agents Phase 2
40 Protein Kinase Inhibitors Phase 2
41
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
42
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
43 Antineoplastic Agents, Hormonal Phase 1
44 Pharmaceutical Solutions Phase 1
45 Ophthalmic Solutions Phase 1
46 Antiemetics Phase 1
47
protease inhibitors Phase 1
48 HIV Protease Inhibitors Phase 1
49 Dexamethasone 21-phosphate Phase 1
50 BB 1101 Phase 1

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Prospective Open Label Study of H.P. Acthar Gel Injection in Patients With Active Non-Infectious Uveitis With Associated Glaucoma Thus High Frequency Regional Corticosteroid and Oral Corticosteroids Cause Intolerable Side-Effects Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
2 Intravitreal Aflibercept (VEGF Trap-Eye) in Neovascular Age-related Macular Degeneration With Limited Response to Ranibizumab Completed NCT02309281 Phase 4 aflibercept 2mg
3 Subtenons Triamcinolone Acetonide Injections for Treatment of Persistent Choroidal Effusions Post Glaucoma Surgery Not yet recruiting NCT02917564 Phase 4 Triamcinolone Acetonide 1 ml of 40 mg/mL suspension
4 A Multicenter Randomized Open-label Trial Comparing the Efficacy and Safety of Infliximab Versus Cyclophosphamide in Subjects With Idiopathic Refractory Scleritis Not yet recruiting NCT03088293 Phase 3 Infliximab;Cyclophosphamide
5 A PhaseI/II Prospective, Randomized, Dose-Ranging Pilot Study of Rituximab in the Treatment of Refractory Scleritis and Non-Infectious Orbital Inflammation Completed NCT00415506 Phase 1, Phase 2 Rituximab
6 Gevokizumab Treatment for Active Scleritis By IL-1 Inhibition (GATSBY) Completed NCT01835132 Phase 1, Phase 2
7 A Phase I/II Study to Investigate Subconjunctival Sirolimus for the Treatment of Active Autoimmune Non-Necrotizing Anterior Scleritis Completed NCT01517074 Phase 1, Phase 2 Sirolimus
8 An Open Label, Multi-centered, Randomized Phase 2 Study to Evaluate the Safety, Tolerability and Bioactivity of Subcutaneous ACTH GeL in PAtients With Scleritis: The ATLAS Study Recruiting NCT03465111 Phase 2 ACTH (adrenocorticotropic hormone) gel
9 Tofacitinib for the Treatment of Inflammatory Eye Disease Active, not recruiting NCT03580343 Phase 2 tofacitinib
10 Iontophoresis Delivery of Dexamethasone Phosphate for Non-infectious, Non-necrotizing Anterior Scleritis, Phase 1 Dose-varying Study Completed NCT01059955 Phase 1 Dexamethasone Phosphate Ophthalmic Solution (EGP-437);Dexamethasone phosphate ophthalmic solution
11 Pilot Study of the Evaluation of Infliximab in the Treatment of Non-Infectious Scleritis Completed NCT00075075 Phase 1 Infliximab
12 Acute Pseudophakic Cystoid Macular Edema Treatment Trial: Intravitreal Ranibizumab Versus Triamcinolone Acetonide Completed NCT02294656 Phase 1 Ranibizumab,;Triamcinolone acetonide
13 An Exploratory, Double Blind, Placebo-controlled, Randomized, Single-dose, Cross-over, Proof of Mechanism Study of Orally Administered PSI-697 in Patients With Scleritis Terminated NCT00367692 Phase 1 PSI-697
14 Observational Study of Visual Outcomes in Retinal Disease Unknown status NCT01613963 Immunosuppressive Agents
15 Comparison of Efficacy of Prostaglandin Analogues (Xalatan) and Aqueous Suppressants (Cosopt) in Reducing Intraocular Pressure Following Selective Laser Trabeculoplasty in the Management of Open-Angle Glaucoma. Unknown status NCT00440336 Cosopt;Xalatan
16 Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis Completed NCT01958567
17 Autologous Perichondrium Transplantation for Replacement of Stem Cells and Their Niche in the Treatment of Necrotizing Scleritis Completed NCT02864823
18 Laboratory of Immunology/National Eye Institute Repository Completed NCT00539370
19 LSFG-SKIN, Laser Speckle Flowgraphy Completed NCT03660618
20 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Anti-toxoplasmosis treatment;Anti-inflammatory treatments
21 Clinical Study on the Regulatory T Cells in the Uveitis Patients Treated by Methotrexate Completed NCT01306474
22 Systemic Immunosupressive Therapy for Eye Diseases (SITE) Cohort Study Completed NCT00116090
23 Evaluation of Immune Responses to Different Antigens in Non Infectious Ocular Inflammatory Diseases Completed NCT00357071
24 Ocular and Immuno-Genetic Manifestations of Sarcoidosis Completed NCT00379275
25 Uveitis/Intraocular Inflammatory Disease Biobank (iBank) Recruiting NCT02656381
26 Exploring Immune Cell Signatures in Autoimmunity and Ocular Surface Stress Recruiting NCT02715323
27 Connection Between Periodontitis and Exudative Age-related Macular Degeneration Recruiting NCT03958461
28 Prevalence of Ocular Manifestations in Inflammatory Rheumatic Diseases Active, not recruiting NCT03753893

Search NIH Clinical Center for Scleritis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


medrysone

Cochrane evidence based reviews: scleritis

Genetic Tests for Scleritis

Anatomical Context for Scleritis

MalaCards organs/tissues related to Scleritis:

40
Eye, Neutrophil, T Cells, Skin, Lung, Thyroid, Testes

Publications for Scleritis

Articles related to Scleritis:

(show top 50) (show all 1638)
# Title Authors PMID Year
1
Current insights in the pathogenesis of scleritis. 61
32504648 2020
2
Bilateral interstitial keratitis, erythema nodosum and atrial fibrillation as presenting signs of polyarteritis nodosa. 61
32140612 2020
3
A case report of fulminant endophthalmitis caused by Streptococcus dysgalactiae in a patient with traumatic corneal laceration. 61
32552664 2020
4
Yellow Sub-Retinal Pigment Epithelium (YSRPE) Deposits: A Novel Sign in Ocular Tuberculosis. 61
32541431 2020
5
Fibromyalgia Syndrome and Eye - a review. 61
32512032 2020
6
Scleritis With Uveal Effusion From Alirocumab. 61
32150753 2020
7
[Nodular scleritis secondary to Wegener's granulomatosis]. 61
32362404 2020
8
Bilateral Necrotizing Scleritis: A Deeper Look at a Vision-Threatening Illness. 61
32453295 2020
9
Escalation to Weekly Adalimumab for the Treatment of Ocular Inflammation. 61
32407246 2020
10
Cataract Surgery in the Setting of Scleritis. 61
32463347 2020
11
More Than Meets the Eye: A Rare Case of Posterior Scleritis Masquerading as Orbital Cellulitis. 61
32566418 2020
12
Psoriasis-associated progressive necrotizing posterior scleritis: A 6-year follow-up. 61
30638053 2020
13
Tubulointerstitial Nephritis and Uveitis Syndrome: Characterization of Clinical Features. 61
32463299 2020
14
Delayed Onset Scleromalacia and Conjunctival Bleb Formation Following Intraoperative Mitomycin C Application during Conjunctival Melanoma Excision. 61
32384819 2020
15
IDIOPATHIC PENETRATION OF CILIA INTO THE POSTERIOR SEGMENT PRESENTING AS SECTORAL SCLERITIS WITH PROGRESSIVE INTRAOCULAR INFLAMMATION. 61
32459699 2020
16
Ocular manifestations in rheumatoid arthritis, connective tissue disease and vasculitis: a systematic review and meta-analysis. 61
32358156 2020
17
Ocular complications and mortality in peripheral ulcerative keratitis and necrotising scleritis: The role of systemic immunosuppression. 61
31872475 2020
18
Biologic therapy in severe and refractory peripheral ulcerative keratitis (PUK). Multicenter study of 34 patients. 61
32497929 2020
19
[Clinical observation of ocular injury caused by chestnut burr]. 61
32450670 2020
20
Experience With 0.1% Tacrolimus Eye Drop for Noninfectious, Non-necrotizing Anterior Scleritis. 61
32404650 2020
21
Nodular Necrotizing-Scleritis Associated with Epstein-Barr Virus Infection: A Case Report. 61
31560578 2020
22
Epidemiology and Clinical Characteristics of Episcleritis and Scleritis in Olmsted County, MN. 61
32437669 2020
23
Acanthamoeba keratitis in Australia: demographics, associated factors, presentation and outcomes: a 15-year case review. 61
31554948 2020
24
Characterization and Management of Inflammatory Eye Disease in Patients with Hidradenitis Suppurativa. 61
32255701 2020
25
Intraocular schwannoma with extrascleral extension. 61
32345045 2020
26
Epidemiology of episcleritis and scleritis in urban Australia. 61
32279425 2020
27
Novel use of adjunctive hyperbaric therapy for fungal scleritis. 61
31765071 2020
28
Retinochoroidal fold with severe discedema in a case of posterior scleritis. 61
32174593 2020
29
Effectiveness of TNF-α blockade in the treatment of refractory non-infectious scleritis: a multicentre study. 61
32301435 2020
30
Giant cell arteritis and scleritis: Does an association exist? 61
31621158 2020
31
Clinical Profile of Patients with Scleritis in Bangladesh. 61
32130057 2020
32
Ophthalmic Drug Delivery Using Iontophoresis: Recent Clinical Applications. 61
31755807 2020
33
Noninfectious Autoimmune Scleritis: Recognition, Systemic Associations, and Therapy. 61
32219644 2020
34
Takayasu's arteritis: associated inflammatory diseases. 61
31969224 2020
35
[Necrotizing scleritis after acanthamoeba keratitis]. 61
32162088 2020
36
A case of giant cell arteritis presenting with nodular posterior scleritis mimicking a choroidal mass. 61
32095658 2020
37
Risks of ophthalmic disorders in patients with systemic lupus erythematosus - a secondary cohort analysis of population-based claims data. 61
32160869 2020
38
Effectiveness of pharmacological agents for the treatment of non-infectious scleritis: a systematic review protocol. 61
32164765 2020
39
PATIENT WITH UNILATERAL CHOROIDAL AND SEROUS RETINAL DETACHMENT WITH A HISTORY OF TREATED PROSTATE CANCER AND UNTREATED SARCOIDOSIS. 61
32058354 2020
40
Fulminant Acanthamoeba Endophthalmitis After Cataract Surgery-A Case Report. 61
32068610 2020
41
Anti-Neutrophil Cytoplasmic Antibody-Associated Ocular Manifestations in Japan: A Review of 18 Patients. 61
32078414 2020
42
Retained intraorbital wooden foreign body presenting with combined anterior and posterior scleritis. 61
32041758 2020
43
Molecular pathobiology of scleritis and its therapeutic implications. 61
31956585 2020
44
Necrotic scleral melt and fungal keratitis-a complication of subtenon triamcinolone acetonide injection. 61
31984430 2020
45
Clinical Features, Treatment, and Visual Outcomes of Japanese Patients with Posterior Scleritis. 61
30806525 2020
46
Scleritis and Endophthalmitis Due to Streptococcus pyogenes Infective Endocarditis. 61
31351838 2020
47
Eye metastasis in lung adenocarcinoma mimicking anterior scleritis: A case report. 61
32047793 2020
48
Eosinophilic granulomatosis with polyangiitis: the multifaceted spectrum of clinical manifestations at different stages of the disease. 61
31762336 2020
49
Xanthophyll: Health benefits and therapeutic insights. 61
31783054 2020
50
Adverse ocular events on miltefosine treatment for post-kala-azar dermal leishmaniasis in India. 61
31610724 2020

Variations for Scleritis

Expression for Scleritis

Search GEO for disease gene expression data for Scleritis.

Pathways for Scleritis

Pathways related to Scleritis according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 TNFRSF1B TNF PTPN22 PRTN3 MMP9 ITGB2
2
Show member pathways
13.66 TNFRSF1B TNF IL5 IL4 IL22 IL1RN
3
Show member pathways
13.52 TNFRSF1B TNF ITGB2 IL5 IL4 IL22
4
Show member pathways
13.39 TNFRSF1B TNF ITGB2 IL5 IL4 IL22
5
Show member pathways
13.28 TNFRSF1B TNF PTPN22 IL5 IL4 IL22
6
Show member pathways
13.11 TNFRSF1B TNF PRTN3 MMP9 ITGB2 IL5
7
Show member pathways
12.85 TNF ITGB2 IL5 IL4 IL22 IFNG
8
Show member pathways
12.59 TNF IL5 IL4 IFNG CTLA4
9
Show member pathways
12.59 TNF IL5 IL4 IL22 IFNG
10
Show member pathways
12.34 TNF IL4 IFNG CRP CCL2
11
Show member pathways
12.34 TNF MMP9 IL5 IL4 IFNG CCL2
12
Show member pathways
12.31 TNFRSF1B TNF CCR6 CCL2
13
Show member pathways
12.25 TNF ITGB2 IL4 IFNG
14 12.12 TNF SELE MMP9 IFNG CCL2
15 12.03 TNF MMP9 IL4 IFNG CCL2
16 11.99 TNF IL5 IL4 IFNG
17 11.99 TNFRSF1B TNF SELE MMP9 CCL2
18 11.88 TNF ITGB2 IFNG CTLA4 CCL2
19 11.86 TNFRSF1B TNF MMP9 ITGB2 IL4 CCL2
20
Show member pathways
11.82 IL4 IL22 IFNG
21 11.81 SELE IL5 IL4 IFNG
22 11.79 TNFRSF1B TNF PTPN22 ITGB2 IL4 IL1RN
23
Show member pathways
11.76 TNF IL5 IL4 IFNG CTLA4
24
Show member pathways
11.69 TNF SELE MMP9 IFNG
25 11.65 TNF MMP9 IL5 IL4 CCL2
26 11.57 TNF ITGB2 IFNG CCL2
27
Show member pathways
11.55 TNFRSF1B TNF IFNG
28 11.53 TNF SELE ITGB2 IFNG CCL2
29 11.52 TNF MMP9 ITGB2
30 11.5 IL5 IL4 IFNG
31 11.46 TNFRSF1B TNF IL4 IL1RN CCL2
32 11.39 TNF SELE IFNG
33
Show member pathways
11.37 TNFRSF1B TNF IFNG
34 11.36 TNFRSF1B IL5 IL4 IFNG
35 11.34 TNF IL5 IL4 IL22 IFNG CCR6
36 11.26 TNF IL5 IL4 IFNG
37 11.21 IL5 IL4 IFNG
38 11.19 MMP9 IFNG CCL2
39 11.06 TNF IL5 IL4 IL22 IFNG
40 11.01 TNF ITGB2 IL5 IL4 IL22 CCL2
41 10.76 IL5 IL4

GO Terms for Scleritis

Cellular components related to Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TNFRSF1B TNF PRTN3 MMP9 IL5 IL4
2 membrane raft GO:0045121 9.55 TNFRSF1B TNF SELE PRTN3 ITGB2
3 extracellular space GO:0005615 9.36 TNF SELE PRTN3 MMP9 IL5 IL4

Biological processes related to Scleritis according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10 TNF PTPN22 IL4 IFNG CRP
2 immune response GO:0006955 9.81 TNFRSF1B TNF IL5 IL4 IL1RN IFNG
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.78 TNF IL4 IFNG
4 response to glucocorticoid GO:0051384 9.77 TNF IL22 IL1RN
5 extrinsic apoptotic signaling pathway GO:0097191 9.71 TNFRSF1B TNF IFNG
6 positive regulation of nitric oxide biosynthetic process GO:0045429 9.7 TNF ITGB2 IFNG
7 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 TNF PTPN22 CCL2
8 humoral immune response GO:0006959 9.67 TNF IFNG CCR6 CCL2
9 regulation of T cell proliferation GO:0042129 9.65 TNFRSF1B CTLA4
10 negative regulation of neuroinflammatory response GO:0150079 9.64 TNFRSF1B IL4
11 positive regulation of podosome assembly GO:0071803 9.64 TNF IL5
12 regulation of neuroinflammatory response GO:0150077 9.63 TNFRSF1B MMP9
13 negative regulation of amyloid-beta clearance GO:1900222 9.63 TNF IFNG
14 positive regulation of MHC class II biosynthetic process GO:0045348 9.62 IL4 IFNG
15 negative regulation of lipid storage GO:0010888 9.62 TNF CRP
16 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.61 TNF IFNG
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 TNFRSF1B TNF IFNG
18 inflammatory response GO:0006954 9.61 TNFRSF1B TNF SELE ITGB2 IL5 IL22
19 positive regulation of NMDA glutamate receptor activity GO:1904783 9.58 IFNG CCL2
20 positive regulation of mononuclear cell migration GO:0071677 9.58 TNF IL4
21 positive regulation of chemokine biosynthetic process GO:0045080 9.58 TNF IL4 IFNG
22 positive regulation of cellular respiration GO:1901857 9.57 IL4 IFNG
23 neuroinflammatory response GO:0150076 9.56 IL4 IFNG
24 microglial cell activation GO:0001774 9.56 TNF ITGB2 IL4 IFNG
25 cellular extravasation GO:0045123 9.55 TNF ITGB2
26 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 TNF IFNG
27 leukocyte migration involved in inflammatory response GO:0002523 9.5 SELE ITGB2 CCR6
28 positive regulation of vitamin D biosynthetic process GO:0060557 9.48 TNF IFNG
29 positive regulation of nitrogen compound metabolic process GO:0051173 9.46 TNF IFNG
30 cytokine-mediated signaling pathway GO:0019221 9.36 TNFRSF1B TNF PRTN3 MMP9 ITGB2 IL5

Molecular functions related to Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 TNFRSF1B TNF SELE PTPN22 PRTN3 MRAP
2 cytokine activity GO:0005125 9.17 TNF IL5 IL4 IL22 IL1RN IFNG

Sources for Scleritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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