Scleromalacia Perforans disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SCL008 MIFTS: 23	Scleromalacia Perforans Categories: Eye diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Scleromalacia Perforans

MalaCards integrated aliases for Scleromalacia Perforans:

Name: Scleromalacia Perforans ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:14230

ICD9CM ³⁴ 379.04

SNOMED-CT ⁶⁷ 26664005

ICD10 ³² H15.05

UMLS ⁷⁰ C0155354

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Summaries for Scleromalacia Perforans

Disease Ontology : ¹² A scleral disease that is characterized by a painless severe necrotizing scleritis where the sclera is white, avascular, and thin. The choroid can become exposed leading to infarction and necrosis of related areas; the sclera can also thin such that the dark uvea protrudes through the front of the eye, forming a staphyloma which has symptom loss of vision and appearance of a dark bulge. Scleromalacia perforans is usually caused by a rare complication of autoimmune disease like rheumatoid arthritis.

MalaCards based summary : Scleromalacia Perforans is related to porphyria and scleritis, and has symptoms including loss of vision An important gene associated with Scleromalacia Perforans is CPOX (Coproporphyrinogen Oxidase), and among its related pathways/superpathways are Biosynthesis of cofactors and Porphyrin and chlorophyll metabolism. Affiliated tissues include eye, retina and myeloid.

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Related Diseases for Scleromalacia Perforans

Diseases related to Scleromalacia Perforans via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)

#	Related Disease	Score	Top Affiliating Genes
1	porphyria	29.8	UROD CPOX
2	scleritis	10.4
3	rheumatoid arthritis	10.2
4	intraocular pressure quantitative trait locus	10.2
5	spondyloarthropathy 1	10.1
6	leprosy 3	10.1
7	retinitis pigmentosa	10.1
8	sjogren syndrome	10.1
9	leukemia, acute myeloid	10.1
10	yemenite deaf-blind hypopigmentation syndrome	10.1
11	graft-versus-host disease	10.1
12	colitis	10.1
13	neuroretinitis	10.1
14	inflammatory spondylopathy	10.1
15	granular corneal dystrophy	10.1
16	sclerosing keratitis	10.1
17	rhinosporidiosis	10.1
18	corneal dystrophy	10.1
19	epidermolysis bullosa	10.1
20	retinitis	10.1
21	skin disease	10.1
22	pyoderma	10.1
23	endophthalmitis	10.1
24	spondylitis	10.1
25	juvenile rheumatoid arthritis	10.1
26	arthritis	10.1
27	pyoderma gangrenosum	10.1
28	ulcerative colitis	10.1
29	vasculitis	10.1
30	chickenpox	10.1
31	myeloid leukemia	10.1
32	crohn's disease	10.1
33	hansen's disease	10.1
34	rheumatoid vasculitis	10.1
35	porphyria, congenital erythropoietic	9.8	UROD CPOX
36	cutaneous porphyria	9.8	UROD CPOX
37	coproporphyria, hereditary	9.7	UROD CPOX
38	porphyria, acute intermittent	9.7	UROD CPOX
39	protoporphyria, erythropoietic, 1	9.7	UROD CPOX
40	acute porphyria	9.7	UROD CPOX
41	variegate porphyria	9.6	UROD CPOX
42	porphyria cutanea tarda	9.5	UROD CPOX

Graphical network of the top 20 diseases related to Scleromalacia Perforans:

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Symptoms & Phenotypes for Scleromalacia Perforans

Symptoms:

¹²

• loss of vision

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Drugs & Therapeutics for Scleromalacia Perforans

Search Clinical Trials , NIH Clinical Center for Scleromalacia Perforans

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Genetic Tests for Scleromalacia Perforans

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Anatomical Context for Scleromalacia Perforans

MalaCards organs/tissues related to Scleromalacia Perforans:

⁴⁰

Eye, Retina, Myeloid

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Publications for Scleromalacia Perforans

Articles related to Scleromalacia Perforans:

(show top 50) (show all 92)

#	Title	Authors	PMID	Year
1	Treatment of Progressive Scleromalacia Perforans by Tectonic Enhancement With Lyophilized Equine Pericardium. ⁶¹	Droutsas K...Petrou P	32925429	2021
2	Leprosy mimicking rheumatoid vasculitis with scleromalacia perforans. ⁶¹	Manoj M...Dhakad U	32624492	2020
3	Scleromalacia perforans in rheumatoid arthritis. ⁶¹	Yangzes S...Ram J	30597078	2019
4	Scleromalacia perforans: a case report. ⁶¹	Ghauri MI...Bashir ZTA	29866188	2018
5	Refractory necrotizing scleritis successfully treated with adalimumab. ⁶¹	Lawuyi LE...Gurbaxani A	27734292	2016
6	Scleromalacia Perforans from Long-Standing Bulbar Conjunctival Rhinosporidiosis. ⁶¹	Bothra N...Tripathy D	27342330	2016
7	[Scleromalacia perforans secondary to ankylosing spondylitis: A case report]. ⁶¹	Elkhoyaali A...Oubaaz A	25976139	2015
8	Ahmed glaucoma valve surgery for necrotizing scleritis with secondary glaucoma. ⁶¹	Ranjan A...Rao A	23636673	2014
9	Bilateral scleromalacia perforans and peripheral corneal thinning in Wegener's granulomatosis. ⁶¹	Reddy SC...Rohana T	22553696	2011
10	Successful treatment of severe nodular scleritis with adalimumab. ⁶¹	Restrepo JP...Molina MP	20155432	2010
11	Infliximab treatment in a case of rheumatoid scleromalacia perforans. ⁶¹	Herrera-Esparza R...Avalos-Diaz E	19888506	2009
12	[Scleromalacia perforans. Rheumatoid arthritis--case report]. ⁶¹	Gheorghe A...Muraru C	19899555	2009
13	A case of Behcet's disease with scleromalacia perforans. ⁶¹	Chan AY...Liu DT	15840606	2005
14	Rare extra-articular manifestation of rheumatoid arthritis: scleromalacia perforans. ⁶¹	Wu CC...Liu HW	15960070	2005
15	Scleromalacia perforans complicating graft-versus-host disease. ⁶¹	Hon C...Au WY	15801949	2005
16	A case of Behcet's disease with scleromalacia perforans. ⁶¹	Sakellariou G...Vounotrypidis P	15637046	2005
17	Anterior scleritis: three case reports and a review of the literature. ⁶¹	Castells DD	15296376	2004
18	Glaucoma implant surgery with autogenous fascia lata in scleromalacia perforans. ⁶¹	Egrilmez S...Andac K	15305561	2004
19	Anterior segment indocyanine green angiography in anterior scleritis and episcleritis. ⁶¹	Guex-Crosier Y...Durig J	13129874	2003
20	Acute scleritis as a manifestation of congenital erythropoietic porphyria. ⁶¹	Veenashree MP...Parthasaradhi A	12072732	2002
21	[Sequestrating senile scleral plaque simulating "necrotizing scleritis". Surgical management]. ⁶¹	Hillenkamp J...Witschel H	10773983	2000
22	Corneal melting and scleromalacia perforans in a patient with pyoderma gangrenosum and acute myeloid leukemia. ⁶¹	Ayyala RS...Armstrong S	9571667	1998
23	Bilateral fascia lata patch grafts in a patient with progressive scleromalacia perforans. ⁶¹	Kachmaryk M...Duffner LA	9156827	1996
24	Case in point. Scleromalacia perforans. ⁶¹	Olivero JJ	8596013	1996
25	Severity of scleritis and episcleritis. ⁶¹	Sainz de la Maza M...Foster CS	8115160	1994
26	Use of split-thickness dermal grafts to repair corneal and scleral defects--a study of 10 patients. ⁶¹	Mauriello JA...Pokorny K	8318477	1993
27	Treatment of scleromalacia perforans with dura mater grafting. ⁶¹	Enzenauer RW...West S	1494440	1992
28	Bilateral paralimbal scleromalacia perforans. ⁶¹	Mader TH...Crosswell HH	2301540	1990
29	Corneal-scleral melt in association with cataract surgery and intraocular lenses: a report of four cases. ⁶¹	Mamalis N...Olson RJ	2299561	1990
30	Ocular manifestations of Wegener's granulomatosis in north India. ⁶¹	Bambery P...Deodhar SD	3227186	1988
31	Use of split-thickness dermal graft in the surgical treatment of corneal and scleral defects. ⁶¹	Mauriello JA...Cinotti DJ	3278615	1988
32	Microscopical studies of necrotising scleritis. I. Cellular aspects. ⁶¹	Young RD...Watson PG	6498132	1984
33	Optic neuritis in inflammatory bowel disease. ⁶¹	Sedwick LA...Behrens MM	6233306	1984
34	Spontaneous remission of glaucoma in scleromalacia perforans: a case report. ⁶¹	Perlstein SH...Yablonski ME	6712066	1984
35	Rheumatoid vasculitis: diagnostic and therapeutic decisions. ⁶¹	Panush RS...Stanley H	6678193	1983
36	Surgical management of scleromalacia perforans--a case report. ⁶¹	Ghafoor SY...Williamson J	6648502	1983
37	[Scleromalacia perforans in a patient with rheumatoid arthritis]. ⁶¹	Pruszczynski M...Sporny S	6675111	1983
38	Scleral melanocytoma. ⁶¹	Lee JS...Minckler DS	7070788	1982
39	Scleromalacia perforans in ulcerative colitis. ⁶¹	Tesar PJ...Lazell RW	7239114	1981
40	[Scleromalacia perforans (author's transl)]. ⁶¹	Dvorak V...Smecka Z	6276031	1981
41	[Collagenase inhibition: an experiment in the treatment of scleromalacia perforans (author's transl)]. ⁶¹	Sommer G...Nover A	232732	1979
42	[Juvenile rheumatoid arthritis and scleromalacia perforans]. ⁶¹	Frati Munari AC...Rojas Dosal JA	687416	1978
43	[Case of scleromalacia perforans]. ⁶¹	Kolushchinskaia RF...Markova TL	568345	1978
44	Unusual intracytoplasmic inclusions in a case of idiopathic scleritis. ⁶¹	Spinak M...Dembitzer HM	213751	1978
45	Periosteal graft in scleromalacia. ⁶¹	Rao GN...Palumbo AJ	600483	1977
46	Fascia lata plasty in scleromalacia perforans [proceedings]. ⁶¹	Winkelman JW	904906	1977
47	[A case of scleromalacia perforans. Diagnostic and therapeutic problems]. ⁶¹	Bronner A...Eglin G	1029546	1976
48	Scleritis and episcleritis. ⁶¹	Watson PG...Hayreh SS	1268179	1976
49	[Cure of scleromalacia perforans manifesting in the course of rheumatoid arthritis with d-penicillamine and fascia lata-autograft (author's transl)]. ⁶¹	Balla L...Kiss G	1214430	1975
50	[Scleromalacia perforans in a patient with chronic rheumatoid arthritis. Report of a case with histopathological study]. ⁶¹	Cardenas Ramirez L...Zaldivar Bernal C	4789182	1973

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Genes for Scleromalacia Perforans

Genes related to Scleromalacia Perforans (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CPOX	Coproporphyrinogen Oxidase	Protein Coding	4.88	DISEASES inferred ¹⁵
2	CYP4V2	Cytochrome P450 Family 4 Subfamily V Member 2	Protein Coding	4.81	DISEASES inferred ¹⁵
3	ACD	ACD Shelterin Complex Subunit And Telomerase Recruitment Factor	Protein Coding	4.77	DISEASES inferred ¹⁵
4	UROD	Uroporphyrinogen Decarboxylase	Protein Coding	4.44	DISEASES inferred ¹⁵
5	MS4A1	Membrane Spanning 4-Domains A1	Protein Coding	4.42	DISEASES inferred ¹⁵

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Variations for Scleromalacia Perforans

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Expression for Scleromalacia Perforans

Search GEO for disease gene expression data for Scleromalacia Perforans.

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Pathways for Scleromalacia Perforans

Pathways related to Scleromalacia Perforans according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Biosynthesis of cofactors ³⁶ Show member pathways Ubiquinone and other terpenoid-quinone biosynthesis ³⁶	11.18	UROD CPOX
2	Porphyrin and chlorophyll metabolism ³⁶ Show member pathways Formation of the active cofactor, UDP-glucuronate ⁶⁵ Glucuronidation ⁶⁵ Glucuronidation ¹ heme biosynthesis ¹ Heme biosynthesis ⁶⁵ Heme Biosynthesis ¹ heme biosynthesis from uroporphyrinogen-III I ¹ heme degradation ¹ Heme degradation ⁶⁵ Metabolism of porphyrins ⁶⁵ tetrapyrrole biosynthesis ¹	10.82	UROD CPOX

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GO Terms for Scleromalacia Perforans

Biological processes related to Scleromalacia Perforans according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heme biosynthetic process	GO:0006783	9.16	UROD CPOX
2	porphyrin-containing compound biosynthetic process	GO:0006779	8.96	UROD CPOX
3	protoporphyrinogen IX biosynthetic process	GO:0006782	8.62	UROD CPOX

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