MCID: SCL008
MIFTS: 23

Scleromalacia Perforans

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Scleromalacia Perforans

MalaCards integrated aliases for Scleromalacia Perforans:

Name: Scleromalacia Perforans 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:14230
ICD9CM 34 379.04
SNOMED-CT 67 26664005
ICD10 32 H15.05
UMLS 70 C0155354

Summaries for Scleromalacia Perforans

Disease Ontology : 12 A scleral disease that is characterized by a painless severe necrotizing scleritis where the sclera is white, avascular, and thin. The choroid can become exposed leading to infarction and necrosis of related areas; the sclera can also thin such that the dark uvea protrudes through the front of the eye, forming a staphyloma which has symptom loss of vision and appearance of a dark bulge. Scleromalacia perforans is usually caused by a rare complication of autoimmune disease like rheumatoid arthritis.

MalaCards based summary : Scleromalacia Perforans is related to porphyria and scleritis, and has symptoms including loss of vision An important gene associated with Scleromalacia Perforans is CPOX (Coproporphyrinogen Oxidase), and among its related pathways/superpathways are Biosynthesis of cofactors and Porphyrin and chlorophyll metabolism. Affiliated tissues include eye, retina and myeloid.

Related Diseases for Scleromalacia Perforans

Graphical network of the top 20 diseases related to Scleromalacia Perforans:



Diseases related to Scleromalacia Perforans

Symptoms & Phenotypes for Scleromalacia Perforans

Symptoms:

12
  • loss of vision

Drugs & Therapeutics for Scleromalacia Perforans

Search Clinical Trials , NIH Clinical Center for Scleromalacia Perforans

Genetic Tests for Scleromalacia Perforans

Anatomical Context for Scleromalacia Perforans

MalaCards organs/tissues related to Scleromalacia Perforans:

40
Eye, Retina, Myeloid

Publications for Scleromalacia Perforans

Articles related to Scleromalacia Perforans:

(show top 50) (show all 92)
# Title Authors PMID Year
1
Treatment of Progressive Scleromalacia Perforans by Tectonic Enhancement With Lyophilized Equine Pericardium. 61
32925429 2021
2
Leprosy mimicking rheumatoid vasculitis with scleromalacia perforans. 61
32624492 2020
3
Scleromalacia perforans in rheumatoid arthritis. 61
30597078 2019
4
Scleromalacia perforans: a case report. 61
29866188 2018
5
Refractory necrotizing scleritis successfully treated with adalimumab. 61
27734292 2016
6
Scleromalacia Perforans from Long-Standing Bulbar Conjunctival Rhinosporidiosis. 61
27342330 2016
7
[Scleromalacia perforans secondary to ankylosing spondylitis: A case report]. 61
25976139 2015
8
Ahmed glaucoma valve surgery for necrotizing scleritis with secondary glaucoma. 61
23636673 2014
9
Bilateral scleromalacia perforans and peripheral corneal thinning in Wegener's granulomatosis. 61
22553696 2011
10
Successful treatment of severe nodular scleritis with adalimumab. 61
20155432 2010
11
Infliximab treatment in a case of rheumatoid scleromalacia perforans. 61
19888506 2009
12
[Scleromalacia perforans. Rheumatoid arthritis--case report]. 61
19899555 2009
13
A case of Behcet's disease with scleromalacia perforans. 61
15840606 2005
14
Rare extra-articular manifestation of rheumatoid arthritis: scleromalacia perforans. 61
15960070 2005
15
Scleromalacia perforans complicating graft-versus-host disease. 61
15801949 2005
16
A case of Behcet's disease with scleromalacia perforans. 61
15637046 2005
17
Anterior scleritis: three case reports and a review of the literature. 61
15296376 2004
18
Glaucoma implant surgery with autogenous fascia lata in scleromalacia perforans. 61
15305561 2004
19
Anterior segment indocyanine green angiography in anterior scleritis and episcleritis. 61
13129874 2003
20
Acute scleritis as a manifestation of congenital erythropoietic porphyria. 61
12072732 2002
21
[Sequestrating senile scleral plaque simulating "necrotizing scleritis". Surgical management]. 61
10773983 2000
22
Corneal melting and scleromalacia perforans in a patient with pyoderma gangrenosum and acute myeloid leukemia. 61
9571667 1998
23
Bilateral fascia lata patch grafts in a patient with progressive scleromalacia perforans. 61
9156827 1996
24
Case in point. Scleromalacia perforans. 61
8596013 1996
25
Severity of scleritis and episcleritis. 61
8115160 1994
26
Use of split-thickness dermal grafts to repair corneal and scleral defects--a study of 10 patients. 61
8318477 1993
27
Treatment of scleromalacia perforans with dura mater grafting. 61
1494440 1992
28
Bilateral paralimbal scleromalacia perforans. 61
2301540 1990
29
Corneal-scleral melt in association with cataract surgery and intraocular lenses: a report of four cases. 61
2299561 1990
30
Ocular manifestations of Wegener's granulomatosis in north India. 61
3227186 1988
31
Use of split-thickness dermal graft in the surgical treatment of corneal and scleral defects. 61
3278615 1988
32
Microscopical studies of necrotising scleritis. I. Cellular aspects. 61
6498132 1984
33
Optic neuritis in inflammatory bowel disease. 61
6233306 1984
34
Spontaneous remission of glaucoma in scleromalacia perforans: a case report. 61
6712066 1984
35
Rheumatoid vasculitis: diagnostic and therapeutic decisions. 61
6678193 1983
36
Surgical management of scleromalacia perforans--a case report. 61
6648502 1983
37
[Scleromalacia perforans in a patient with rheumatoid arthritis]. 61
6675111 1983
38
Scleral melanocytoma. 61
7070788 1982
39
Scleromalacia perforans in ulcerative colitis. 61
7239114 1981
40
[Scleromalacia perforans (author's transl)]. 61
6276031 1981
41
[Collagenase inhibition: an experiment in the treatment of scleromalacia perforans (author's transl)]. 61
232732 1979
42
[Juvenile rheumatoid arthritis and scleromalacia perforans]. 61
687416 1978
43
[Case of scleromalacia perforans]. 61
568345 1978
44
Unusual intracytoplasmic inclusions in a case of idiopathic scleritis. 61
213751 1978
45
Periosteal graft in scleromalacia. 61
600483 1977
46
Fascia lata plasty in scleromalacia perforans [proceedings]. 61
904906 1977
47
[A case of scleromalacia perforans. Diagnostic and therapeutic problems]. 61
1029546 1976
48
Scleritis and episcleritis. 61
1268179 1976
49
[Cure of scleromalacia perforans manifesting in the course of rheumatoid arthritis with d-penicillamine and fascia lata-autograft (author's transl)]. 61
1214430 1975
50
[Scleromalacia perforans in a patient with chronic rheumatoid arthritis. Report of a case with histopathological study]. 61
4789182 1973

Variations for Scleromalacia Perforans

Expression for Scleromalacia Perforans

Search GEO for disease gene expression data for Scleromalacia Perforans.

Pathways for Scleromalacia Perforans

GO Terms for Scleromalacia Perforans

Biological processes related to Scleromalacia Perforans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme biosynthetic process GO:0006783 9.16 UROD CPOX
2 porphyrin-containing compound biosynthetic process GO:0006779 8.96 UROD CPOX
3 protoporphyrinogen IX biosynthetic process GO:0006782 8.62 UROD CPOX

Sources for Scleromalacia Perforans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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