MCID: SCL009
MIFTS: 53

Sclerosing Cholangitis

Categories: Gastrointestinal diseases, Rare diseases, Liver diseases

Aliases & Classifications for Sclerosing Cholangitis

MalaCards integrated aliases for Sclerosing Cholangitis:

Name: Sclerosing Cholangitis 12 76 15
Cholangitis, Sclerosing 44 73
Primary Sclerosing Cholangitis 73
Fibrosing Cholangitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14268
ICD10 33 K83.0
MeSH 44 D015209
UMLS 73 C0008313

Summaries for Sclerosing Cholangitis

MalaCards based summary : Sclerosing Cholangitis, also known as cholangitis, sclerosing, is related to sclerosing cholangitis, neonatal and autoimmune pancreatitis, and has symptoms including icterus An important gene associated with Sclerosing Cholangitis is CLDN1 (Claudin 1), and among its related pathways/superpathways are Allograft rejection and HTLV-I infection. The drugs Vancomycin and Ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Primary sclerosing cholangitis (PSC) is a long-term progressive disease of the liver and gallbladder... more...

Related Diseases for Sclerosing Cholangitis

Diseases in the Sclerosing Cholangitis family:

Cholangitis, Primary Sclerosing Secondary Sclerosing Cholangitis

Diseases related to Sclerosing Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 269)
# Related Disease Score Top Affiliating Genes
1 sclerosing cholangitis, neonatal 35.1 CLDN1 DCDC2
2 autoimmune pancreatitis 31.7 CFTR HLA-DRB1 TNF
3 autoimmune hepatitis 30.9 CD40LG GGT1 HLA-DRB1
4 pure red-cell aplasia 30.6 ALB HLA-B HLA-DRB1
5 burns 30.6 ALB TNF
6 gastroenteritis 30.2 ALB FUT2 TNF
7 primary biliary cirrhosis 30.1 ABCB4 ALB CD40LG GGT1
8 peritonitis 30.0 ALB MPO TNF
9 psoriatic arthritis 29.9 HLA-B HLA-C HLA-DRB1 TNF
10 hepatitis a 29.8 ALB CD40LG TNF
11 obstructive jaundice 29.8 ALB GGT1 GPBAR1 TNF
12 suppurative cholangitis 29.7 ABCB4 MPO TNF
13 autoimmune disease 29.6 CD40LG HLA-B HLA-DRB1 TNF
14 acquired immunodeficiency syndrome 29.5 ALB CD40LG HLA-B TNF
15 cholestasis 29.5 ABCB11 ABCB4 GGT1 NR1I2
16 churg-strauss syndrome 29.5 CD40LG MPO TNF
17 liver disease 29.4 ABCB11 ABCB4 ALB GGT1 TNF
18 celiac disease 1 29.1 ALB CD40LG TNF
19 pneumonia 29.0 CD40LG MPO TNF
20 cholangitis, primary sclerosing 29.0 ABCB4 BPI CFTR CTSG FUT2 GGT1
21 cystic fibrosis 28.8 BPI CFTR CTSG MPO
22 bronchiectasis 28.6 BPI CFTR CTSG MPO
23 glomerulonephritis 28.6 ALB CD40LG MPO
24 bile duct disease 28.2 ABCB11 ABCB4 ALB GGT1 GPBAR1 NR1I2
25 biliary tract disease 28.1 ABCB11 ABCB4 ALB GGT1 GPBAR1 NR1I2
26 intrahepatic cholestasis 27.8 ABCB11 ABCB4 ALB GGT1 GPBAR1 NR1I2
27 systemic lupus erythematosus 27.8 ALB CD40LG CTSG HLA-DRB1 MPO TNF
28 inflammatory bowel disease 27.7 ALB BPI CTSG HLA-B HLA-DRB1 MPO
29 cholangitis 26.7 ABCB11 ABCB4 ALB CD40LG CFTR CLDN1
30 ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis 12.7
31 secondary sclerosing cholangitis 12.5
32 igg4-related sclerosing cholangitis 12.2
33 pancreatitis, sclerosing cholangitis, and sicca complex 12.2
34 isolated neonatal sclerosing cholangitis 12.1
35 bile duct carcinoma 11.6
36 cholangiocarcinoma 11.6
37 postherpetic neuralgia 10.9 HLA-B HLA-DRB1
38 idiopathic inflammatory myopathy 10.8 HLA-B HLA-DRB1
39 glaucomatocyclitic crisis 10.8 HLA-B HLA-C
40 colitis 10.8
41 ulcerative colitis 10.7
42 beryllium disease 10.7 HLA-DRB1 TNF
43 pityriasis rosea 10.7 HLA-B HLA-C HLA-DRB1
44 pars planitis 10.6 HLA-B HLA-DRB1
45 anteroseptal myocardial infarction 10.6 ALB FUT2 HLA-DRB1
46 pancreatitis 10.6
47 paraneoplastic pemphigus 10.6 HLA-B HLA-C HLA-DRB1
48 chronic beryllium disease 10.6 HLA-DRB1 TNF
49 autoimmune inner ear disease 10.6 MPO TNF
50 hepatitis 10.6

Graphical network of the top 20 diseases related to Sclerosing Cholangitis:



Diseases related to Sclerosing Cholangitis

Symptoms & Phenotypes for Sclerosing Cholangitis

UMLS symptoms related to Sclerosing Cholangitis:


icterus

GenomeRNAi Phenotypes related to Sclerosing Cholangitis according to GeneCards Suite gene sharing:

26 (show all 31)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.15 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.15 HLA-C HLA-B CTSG
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.15 HLA-C HLA-B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.15 HLA-C HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.15 HLA-C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.15 MPO
7 Increased shRNA abundance (Z-score > 2) GR00366-A-13 10.15 CTSG
8 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.15 GGT1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.15 GGT1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.15 HLA-C CTSG
11 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.15 HLA-C HLA-B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.15 MPO
13 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.15 CTSG
14 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.15 HLA-C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.15 GGT1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.15 MPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.15 HLA-C HLA-B
18 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.15 MPO
19 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.15 HLA-C HLA-B
20 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.15 HLA-C
21 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.15 CTSG
22 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.15 MPO
23 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.15 HLA-C HLA-B
24 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.15 MPO
25 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.15 CTSG
26 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.15 HLA-C
27 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.15 MPO
28 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.15 HLA-C GGT1 MPO HLA-B
29 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.15 MPO
30 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.15 HLA-C HLA-B
31 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.15 HLA-C

MGI Mouse Phenotypes related to Sclerosing Cholangitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.7 ABCB11 ABCB4 ALB CD40LG CFTR CLDN1
2 liver/biliary system MP:0005370 9.23 ABCB11 ABCB4 ALB CFTR CTSG GPBAR1

Drugs & Therapeutics for Sclerosing Cholangitis

Drugs for Sclerosing Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vancomycin Approved Phase 4,Phase 3,Phase 1,Not Applicable 1404-90-6 441141 14969
2
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
3
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
4
Ofloxacin Approved Phase 4 82419-36-1 4583
5
Leflunomide Approved, Investigational Phase 4 75706-12-6 3899
6
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
8
Prednisone Approved, Vet_approved Phase 4,Not Applicable 53-03-2 5865
9 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Antibiotics, Antitubercular Phase 4,Phase 2,Not Applicable
13 Antibodies Phase 4,Phase 2,Phase 1,Not Applicable
14 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
15 Antirheumatic Agents Phase 4,Phase 1,Phase 2
16 glucocorticoids Phase 4,Phase 1
17 Hormone Antagonists Phase 4,Phase 1
18 Hormones Phase 4,Phase 1
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 1
20 Immunoglobulin G Phase 4,Phase 1,Phase 2,Not Applicable
21 Immunoglobulins Phase 4,Phase 2,Phase 1,Not Applicable
22 Immunosuppressive Agents Phase 4,Phase 2,Phase 1
23 Bile Acids and Salts Phase 4,Phase 2,Phase 1
24 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
25 Antitubercular Agents Phase 4
26 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
27 Cytochrome P-450 Enzyme Inhibitors Phase 4
28 Renal Agents Phase 4
29 Topoisomerase Inhibitors Phase 4
30 Antineoplastic Agents, Hormonal Phase 4
31 Methylprednisolone acetate Phase 4
32 Methylprednisolone Hemisuccinate Phase 4
33 Prednisolone acetate Phase 4
34 Prednisolone hemisuccinate Phase 4
35 Prednisolone phosphate Phase 4
36
Bezafibrate Approved, Investigational Phase 3 41859-67-0 39042
37
Ursodeoxycholic acid Approved, Investigational Phase 2, Phase 3,Phase 1 128-13-2 31401
38 Antimetabolites Phase 3,Phase 1,Phase 2,Not Applicable
39 Hypolipidemic Agents Phase 3,Phase 1,Phase 2
40 Lipid Regulating Agents Phase 3,Phase 1,Phase 2
41 Cholagogues and Choleretics Phase 2, Phase 3,Phase 1
42
Cladribine Approved, Investigational Phase 2 4291-63-8 20279
43
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
44
Curcumin Approved, Investigational Phase 1, Phase 2 458-37-7 969516
45
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
46
Dobutamine Approved Phase 2 34368-04-2 36811
47
Norepinephrine Approved Phase 2 51-41-2 439260
48
Fenofibrate Approved Phase 1, Phase 2 49562-28-9 3339
49
Tretinoin Approved, Investigational, Nutraceutical Phase 2,Phase 1 302-79-4 5538 444795
50 Anti-HIV Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 92)
# Name Status NCT ID Phase Drugs
1 Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients Unknown status NCT02605213 Phase 4 Vancomycin;Placebo
2 Antibiotics to Decrease Post ERCP Cholangitis Recruiting NCT03087656 Phase 4 Ceftriaxone;Levofloxacin
3 Leflunomide for Maintenance of Remission in IgG4 Related Disease Recruiting NCT02703194 Phase 4 Prednisone;Leflunomide
4 A Pilot Study to Characterize Bile Acid Metabolism and Dysbiosis in Primary Sclerosing Cholangitis Active, not recruiting NCT02464020 Phase 4 Vancomycin
5 Short-term Stenting Versus Balloon Dilatation for Dominant Strictures in Primary Sclerosing Cholangitis Unknown status NCT01398917 Phase 3
6 Probiotics in Patients With Primary Sclerosing Cholangitis Unknown status NCT00161148 Phase 3 Probiotics
7 The Effect of Bezafibrate on Cholestatic Itch Unknown status NCT02701166 Phase 3 Bezafibrate;Placebo
8 Trial of High-dose Urso in Primary Sclerosing Cholangitis Completed NCT00059202 Phase 2, Phase 3 Ursodeoxycholic Acid
9 Primary Sclerosing Cholangitis With Oral Vancomycin by the Study of Its Antimicrobial and Immunomodulating Effects Active, not recruiting NCT01802073 Phase 3 Oral Vancomycin
10 Efficacy and Safety of Vedolizumab Intravenous (IV) in the Treatment of Primary Sclerosing Cholangitis in Subjects With Underlying Inflammatory Bowel Disease Withdrawn NCT03035058 Phase 3 Vedolizumab;Placebo
11 PERSEUS: Preliminary Efficacy and Safety of Cenicriviroc in Adult Subjects With Primary Sclerosing Cholangitis Completed NCT02653625 Phase 2 Cenicriviroc 150 mg
12 Phase 2 Study of NGM282 in Patients With Primary Sclerosing Cholangitis Completed NCT02704364 Phase 2
13 Obeticholic Acid (OCA) in Primary Sclerosing Cholangitis (PSC) Completed NCT02177136 Phase 2 OCA;Placebo
14 Norursodeoxycholic Acid in the Treatment of Primary Sclerosing Cholangitis Completed NCT01755507 Phase 2 norUDCA;Placebo
15 Open Label Study to Evaluate Safety and Efficacy of LUM001 in Patients With Primary Sclerosing Cholangitis Completed NCT02061540 Phase 2 LUM001
16 Simtuzumab (GS-6624) in the Prevention of Progression of Liver Fibrosis in Subjects With Primary Sclerosing Cholangitis (PSC) Completed NCT01672853 Phase 2
17 Phase II Pilot Study of Cladribine (2-Chlorodeoxyadenosine; 2-CdA) for Early Stage Primary Sclerosing Cholangitis Completed NCT00004762 Phase 2 cladribine
18 Rituximab in IgG4-RD: A Phase 1-2 Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
19 Mitomycin C Therapy for Patients With Primary Sclerosing Cholangitis Recruiting NCT01688024 Phase 2 Mitomycin C;Normal saline
20 A Trial of BTT1023 in Patients With Primary Sclerosing Cholangitis Recruiting NCT02239211 Phase 2 BTT1023
21 A Study Evaluating the Safety and Efficacy of Curcumin in Patients With Primary Sclerosing Cholangitis Recruiting NCT02978339 Phase 1, Phase 2 Curcumin
22 A Research Study to Evaluate Safety and Efficacy of DUR-928 in Subjects With Primary Sclerosing Cholangitis (PSC) Recruiting NCT03394781 Phase 2 DUR-928
23 A POC and Dose-Ranging Study of HTD1801 in PSC Patients Recruiting NCT03333928 Phase 2 HTD1801;Placebo
24 An Efficacy Trial of Low Dose All-trans Retinoic Acid in Patients With Primary Sclerosing Cholangitis Recruiting NCT03359174 Phase 2 All-trans retinoic acid
25 Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases Recruiting NCT01988506 Phase 2 Interleukin 2
26 Molecular Adsorbent Recirculating System (MARS®) in Hypoxic Hepatitis Recruiting NCT01690845 Phase 2
27 Fecal Microbiota Transplantation for the Treatment of Primary Sclerosing Cholangitis. Active, not recruiting NCT02424175 Phase 1, Phase 2
28 Umbilical Cord Mesenchymal Stem Cells in Primary Sclerosing Cholangitis Active, not recruiting NCT03516006 Phase 1, Phase 2 UCMSC;UDCA
29 Safety, Tolerability, and Efficacy of GS-9674 in Adults With Primary Sclerosing Cholangitis Without Cirrhosis Active, not recruiting NCT02943460 Phase 2 GS-9674;Placebo to match GS-9674
30 A Study of Oral Hymecromone to Treat Adults With Primary Sclerosing Cholangitis Not yet recruiting NCT02780752 Phase 1, Phase 2 hymecromone
31 Sulfasalazine for the Treatment of Primary Sclerosing Cholangitis Not yet recruiting NCT03561584 Phase 2 Sulfasalazine;Placebo
32 A Single-arm,Phase IIa,Safety and Efficacy Trial of Selected MSCs in the Treatment of Patients With PSC & AiH Not yet recruiting NCT02997878 Phase 1, Phase 2
33 Thalidomide for the Treatment of Primary Sclerosing Cholangitis (PSC) Terminated NCT00953615 Phase 2 Thalidomide
34 Pilot Study of Fenofibrate for PSC Terminated NCT01142323 Phase 1, Phase 2 fenofibrate
35 The Value of CT Cholangiography in Primary Sclerosing Cholangitis Withdrawn NCT00588458 Phase 2
36 Gastrointestinal Microbiota in Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin Completed NCT01322386 Phase 1 Vancomycin
37 Erlotinib for Chemoprevention in Trisomy 7 Positive Primary Sclerosing Cholangitis (PSC) Completed NCT00955149 Phase 1 Erlotinib (Tarceva)
38 Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis Completed NCT01088607 Phase 1 ursodeoxycholic acid (UDCA)
39 A Pilot Study of Vancomycin or Metronidazole in Patients With Primary Sclerosing Cholangitis Completed NCT01085760 Phase 1 Vancomycin;Vancomycin;Metronidazole;Metronidazole;Vancomycin
40 Minocycline in Primary Sclerosing Cholangitis (PSC) Completed NCT00630942 Phase 1 Minocycline
41 A Pilot Study of Xifaxan to Treat Patients With PSC Completed NCT01695174 Phase 1 Xifaxan
42 Pilot Study of Budesonide for Patients With Primary Sclerosing Cholangitis Completed NCT00004842 Phase 1 budesonide
43 Evaluation of DHA for the Treatment of PSC Completed NCT00325013 Phase 1 Docosahexaenoic Acid (DHA)
44 Combination Therapy With Ursodeoxycholic Acid (UDCA) and All-Trans Retinoic Acid (ATRA) for Treatment of Primary Sclerosing Cholangitis Completed NCT01456468 Phase 1 Oral all-trans retinoic acid (ATRA)
45 A Study of HTD1801 in Healthy Subjects Completed NCT03099603 Phase 1 HTD1801
46 Optical Frequency Domain Imaging (OFDI) for Biliary Stricture Imaging Completed NCT01439620 Phase 1
47 Biliary Excretion of Conjugated Bile Acids in Humans Measured by 11C-cholylsarcosine PET/CT Completed NCT01879735 Phase 1 11C-CSar;ICG
48 Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin Recruiting NCT02137668 Phase 1 Oral Vancomycin
49 Treatment of IgG4-Related Disease With Revlimid and Rituximab Recruiting NCT02705638 Phase 1 Rituximab;Lenalidomide
50 A Study Of Ursolic Acid For Primary Sclerosing Cholangitis Withdrawn NCT03216876 Phase 1 Ursolic acid

Search NIH Clinical Center for Sclerosing Cholangitis

Cochrane evidence based reviews: cholangitis, sclerosing

Genetic Tests for Sclerosing Cholangitis

Anatomical Context for Sclerosing Cholangitis

MalaCards organs/tissues related to Sclerosing Cholangitis:

41
Liver, Eye, Skin, Colon, T Cells, Testes, Thyroid

Publications for Sclerosing Cholangitis

Articles related to Sclerosing Cholangitis:

(show top 50) (show all 1150)
# Title Authors Year
1
Clinical guidelines for primary sclerosing cholangitis 2017. ( 29951926 )
2018
2
The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease. ( 29435321 )
2018
3
Symptoms do not Correlate With Findings From Colonoscopy in Children with Inflammatory Bowel Disease and Primary Sclerosing Cholangitis. ( 29378308 )
2018
4
Tumor Necrosis Factor Alpha Inhibition for Inflammatory Bowel Disease after Liver Transplant for Primary Sclerosing Cholangitis. ( 29862092 )
2018
5
Serum miRNA-122 is an independent biomarker of survival in patients with primary sclerosing cholangitis. ( 29922759 )
2018
6
Vedolizumab in patients with concurrent primary sclerosing cholangitis and inflammatory bowel disease does not improve liver biochemistry but is safe and effective for the bowel disease. ( 29377235 )
2018
7
Editorial: the role of colonic inflammation in the progression of liver disease in primary sclerosing cholangitis-Authors' reply and Letter: the effects of colectomy prior to the diagnosis of primary sclerosing cholangitis on prognosis may have been overestimated. ( 29314129 )
2018
8
Lack of Correlation of Liver Tests With Fibrosis Stage at Diagnosis in Pediatric Primary Sclerosing Cholangitis. ( 29356767 )
2018
9
A promising medium-term follow-up of pediatric sclerosing cholangitis: Mild phenotype or early diagnosis? ( 29316057 )
2018
10
The role of MRI and ERCP in the evaluation of disease activity and severity in primary sclerosing cholangitis. ( 29901259 )
2018
11
Peribiliary Cysts presenting as Primary Sclerosing Cholangitis. ( 29432923 )
2018
12
Letter: the effects of colectomy prior to the diagnosis of primary sclerosing cholangitis on prognosis may have been overestimated. ( 29314130 )
2018
13
Reviewing the Risk of Colorectal Cancer in Inflammatory Bowel Disease After Liver Trasnplantation for Primary Sclerosing Cholangitis. ( 29361103 )
2018
14
Differential diagnosis of cholangiocarcinoma and IgG4-related sclerosing cholangitis by fluorescence inA situ hybridization using transpapillary forceps biopsy specimens. ( 29532638 )
2018
15
Endoscopic management of primary sclerosing cholangitis. ( 29883229 )
2018
16
Effects of vedolizumab, adalimumab and infliximab on biliary inflammation in individuals with primary sclerosing cholangitis and inflammatory bowel disease. ( 29808485 )
2018
17
Kindler syndrome in a patient with colitis and primary sclerosing cholangitis: coincidence or association? ( 29634879 )
2018
18
Localized intrahepatic IgG4-related sclerosing cholangitis (IgG4-SC) as an additional type of IgG4-SC: a systematic analysis of 12 cases. ( 29313399 )
2018
19
Diagnosis of cholangiocarcinoma in primary sclerosing cholangitis. ( 29781738 )
2018
20
Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis. ( 29851098 )
2018
21
Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice. ( 29802947 )
2018
22
The significance of serum IgG<sub>4</sub>and CA19-9, autoantibodies in diagnosis and differential diagnosis of IgG<sub>4</sub>-related sclerosing cholangitis. ( 29272982 )
2018
23
Secondary sclerosing cholangitis in critically ill patients after a traffic accident-a new entity that should be considered in death classification. ( 29484493 )
2018
24
Update in the Care and Management of Patients with Primary Sclerosing Cholangitis. ( 29886518 )
2018
25
Patient-reported outcome measures used in patients with primary sclerosing cholangitis: a systematic review. ( 29976215 )
2018
26
Sclerosing Cholangitis Like Changes on Magnetic Resonance Cholangiography in Patients with Drug Induced Liver Injury. ( 29966706 )
2018
27
Anesthetic Care of 2 Siblings With Neonatal Ichthyosis and Sclerosing Cholangitis Syndrome: Case Reports. ( 29738332 )
2018
28
Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease. ( 29852184 )
2018
29
Right Sided Colonic Juvenile Polyp (polyps) in Pediatric Primary Sclerosing Cholangitis Patients. ( 29931365 )
2018
30
Cholestasis after TIPS placement in a patient with primary sclerosing cholangitis: an uncommon complication. ( 29278002 )
2018
31
Review article: the evidence that vancomycin is a therapeutic option for primary sclerosing cholangitis. ( 29411404 )
2018
32
Risk factors and prognosis for recurrent primary sclerosing cholangitis after liver transplantation: a Nordic Multicentre Study. ( 29301479 )
2018
33
An Imaging Biomarker for Assessing Hepatic Function in Patients with Primary Sclerosing Cholangitis. ( 29775791 )
2018
34
Primary sclerosing cholangitis is associated with abnormalities in CFTR. ( 29807875 )
2018
35
Crohn's Disease Behavior and Location is Altered when Associated with Primary Sclerosing Cholangitis. ( 29333790 )
2018
36
High Risk of Advanced Colorectal Neoplasia in Patients With Primary Sclerosing Cholangitis Associated With Inflammatory Bowel Disease. ( 29378311 )
2018
37
Association between smoking and risk of primary sclerosing cholangitis: A systematic review and meta-analysis. ( 29881604 )
2018
38
The impact of ileal pouch-anal anastomosis on graft survival following liver transplantation for primary sclerosing cholangitis. ( 29882252 )
2018
39
Editorial: the role of colonic inflammation in the progression of liver disease in patients with primary sclerosing cholangitis. ( 29314124 )
2018
40
Loss of tolerance to gut immunity protein, glycoprotein 2 (GP2) is associated with progressive disease course in primary sclerosing cholangitis. ( 29321484 )
2018
41
No Superiority of Stents vs Balloon Dilatation for Dominant Strictures in Patients With Primary Sclerosing Cholangitis. ( 29803836 )
2018
42
Quality of life and primary sclerosing cholangitis: the business of defining what counts. ( 29315689 )
2018
43
The Immunobiology of RANKL and Myeloid Derived Suppressor Cell Activation in IgG4-related Sclerosing Cholangitis. ( 29774578 )
2018
44
Autoimmune hepatitis with sclerosing cholangitis in a patient with thiopurine methyltransferase deficiency: case presentation. ( 28523321 )
2017
45
Very Severe Secondary Sclerosing Cholangitis as a Sequela of Influenza. ( 28683859 )
2017
46
Increased cholestatic enzymes in two patients with long-term history of ulcerative colitis: consider primary biliary cholangitis not always primary sclerosing cholangitis. ( 28951510 )
2017
47
Isolated IgG4-related sclerosing cholangitis misdiagnosed as malignancy in an area with endemic cholangiocarcinoma: a case report. ( 28202062 )
2017
48
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. ( 28779025 )
2017
49
Efficacy of oral vancomycin in recurrent primary sclerosing cholangitis following liver transplantation. ( 28951512 )
2017
50
Primary sclerosing cholangitis: A review and update. ( 29977644 )
2017

Variations for Sclerosing Cholangitis

Expression for Sclerosing Cholangitis

Search GEO for disease gene expression data for Sclerosing Cholangitis.

Pathways for Sclerosing Cholangitis

GO Terms for Sclerosing Cholangitis

Cellular components related to Sclerosing Cholangitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.86 ABCB11 ABCB4 BPI CD40LG CFTR CLDN1
2 azurophil granule lumen GO:0035578 9.65 BPI CTSG MPO
3 recycling endosome membrane GO:0055038 9.58 CFTR HLA-B HLA-C
4 ER to Golgi transport vesicle membrane GO:0012507 9.54 HLA-B HLA-C HLA-DRB1
5 cell surface GO:0009986 9.5 CD40LG CFTR CTSG HLA-B HLA-C HLA-DRB1
6 MHC class I protein complex GO:0042612 9.46 HLA-B HLA-C
7 extracellular exosome GO:0070062 9.4 ABCB11 ABCB4 ALB BPI CFTR CTSG
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.33 HLA-B HLA-C HLA-DRB1
9 intercellular canaliculus GO:0046581 9.32 ABCB11 ABCB4
10 integral component of membrane GO:0016021 10.27 ABCB11 ABCB4 CD40LG CFTR CLDN1 FUT2
11 plasma membrane GO:0005886 10.21 ABCB11 ABCB4 CD40LG CFTR CLDN1 CTSG

Biological processes related to Sclerosing Cholangitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.85 BPI CTSG HLA-B HLA-C MPO
2 defense response to bacterium GO:0042742 9.71 BPI CTSG MPO TNF
3 response to lipopolysaccharide GO:0032496 9.67 ABCB4 CLDN1 CTSG MPO
4 interferon-gamma-mediated signaling pathway GO:0060333 9.61 HLA-B HLA-C HLA-DRB1
5 response to dexamethasone GO:0071548 9.51 ABCB4 CLDN1
6 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.49 HLA-B HLA-C
7 xenobiotic transport GO:0042908 9.48 ABCB4 NR1I2
8 antigen processing and presentation GO:0019882 9.33 HLA-B HLA-C HLA-DRB1
9 drug export GO:0046618 9.32 ABCB4 NR1I2
10 regulation of immunoglobulin secretion GO:0051023 9.26 CD40LG TNF
11 immune response GO:0006955 9.17 BPI CD40LG CTSG HLA-B HLA-C HLA-DRB1
12 negative regulation of growth of symbiont in host GO:0044130 9.13 CTSG MPO TNF

Molecular functions related to Sclerosing Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.13 ABCB11 ABCB4 CFTR
2 peptide antigen binding GO:0042605 8.8 HLA-B HLA-C HLA-DRB1

Sources for Sclerosing Cholangitis

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
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62 PubMed
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69 SNOMED-CT via HPO
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71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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