MCID: SCL017
MIFTS: 32

Sclerosing Hemangioma

Categories: Cancer diseases, Cardiovascular diseases, Skin diseases

Aliases & Classifications for Sclerosing Hemangioma

MalaCards integrated aliases for Sclerosing Hemangioma:

Name: Sclerosing Hemangioma 12 15 71
Cutaneous Fibrous Histiocytoma 71
Sclerosing Haemangioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:495
UMLS 71 C0002991 C1509148

Summaries for Sclerosing Hemangioma

MalaCards based summary : Sclerosing Hemangioma, also known as cutaneous fibrous histiocytoma, is related to pulmonary sclerosing hemangioma and endobronchial leiomyoma. An important gene associated with Sclerosing Hemangioma is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways is Neuroscience. The drugs Fluorouracil and Parathyroid hormone have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and liver.

Wikipedia : 74 A dermatofibroma, or benign fibrous histiocytomas, is a benign skin... more...

Related Diseases for Sclerosing Hemangioma

Diseases related to Sclerosing Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 478)
# Related Disease Score Top Affiliating Genes
1 pulmonary sclerosing hemangioma 31.9 SYP SFTPB NKX2-1 KRT7 ENO2 CTNNB1
2 endobronchial leiomyoma 30.3 SYP ENO2
3 cavernous hemangioma 30.0 SYP NKX2-1 MUC1 KRT7
4 intrahepatic cholangiocarcinoma 29.9 MUC1 KRT7 CTNNB1
5 cholangiocarcinoma 29.9 MUC1 KRT7 CTNNB1
6 bile duct cystadenocarcinoma 29.9 MUC1 KRT7
7 tuberous sclerosis 29.7 SYP ENO2 CHGA
8 adenocarcinoma 29.7 NKX2-1 MUC1 KRT7 CTNNB1
9 lung disease 29.6 SFTPB NKX2-1 MUC1 ENO2
10 pulmonary blastoma 29.5 SYP NKX2-1 CHGA CALCA
11 papillary adenoma 29.5 SYP NKX2-1 KRT7
12 paraganglioma 29.4 SYP ENO2 CHGA CALCA
13 cystadenocarcinoma 29.4 PGR MUC1 KRT7
14 sarcoma, synovial 29.2 MUC1 KRT7 CTNNB1
15 papillary adenocarcinoma 29.1 PGR NKX2-1 MUC1 KRT7
16 lung benign neoplasm 28.9 SYP NKX2-1 KRT7 ENO2 CHGA
17 fibrolamellar carcinoma 28.8 SYP KRT7 GAST CTNNB1
18 lung cancer susceptibility 3 28.7 SFTPB NKX2-1 MUC1 KRT7 CTNNB1
19 hemangioma 28.7 SYP SFTPB PGR NKX2-1 MUC1 KRT7
20 adenoma 28.6 SYP MUC1 KRT7 CTNNB1 CHGA
21 neuroendocrine tumor 28.6 SYP NKX2-1 GAST ENO2 CHGA CALCA
22 small cell carcinoma 27.3 SYP NKX2-1 MUC1 KRT7 GAST ENO2
23 cerebral primitive neuroectodermal tumor 10.4 SYP MUC1
24 primary hepatic neuroendocrine carcinoma 10.4 SYP CHGA
25 acinar cell cystadenocarcinoma 10.4 SYP CHGA
26 cervical large cell neuroendocrine carcinoma 10.4 SYP CHGA
27 epithelioid malignant peripheral nerve sheath tumor 10.4 MUC1 CHGA
28 pilomatrix carcinoma 10.4 MUC1 ENO2
29 intracranial cysts 10.4 MUC1 ENO2
30 anaplastic ependymoma 10.4 SYP MUC1
31 papillary thymic adenocarcinoma 10.4 SYP CHGA
32 lipid pneumonia 10.4 SFTPB MUC1
33 esophageal adenoid cystic carcinoma 10.4 SYP CHGA
34 interstitial pneumonitis, desquamative, familial 10.4 SFTPB MUC1
35 spindle cell thymoma 10.4 MUC1 ENO2
36 respiratory distress syndrome in premature infants 10.4 SFTPB NKX2-1
37 meningeal melanocytoma 10.4 MUC1 ENO2
38 pulmonary large cell neuroendocrine carcinoma 10.4 SYP CHGA
39 binswanger's disease 10.4 SYP CHGA
40 acute interstitial pneumonia 10.4 SFTPB MUC1
41 neonatal respiratory failure 10.4 SFTPB NKX2-1
42 chronic tympanitis 10.4 PGR MUC1
43 pancreatic acinar cell adenocarcinoma 10.4 SYP CHGA
44 ureter transitional cell carcinoma 10.4 ENO2 CHGA
45 malignant melanocytic neoplasm of the peripheral nerve sheath 10.4 SYP ENO2
46 extra-adrenal pheochromocytoma 10.4 SYP CHGA
47 breast scirrhous carcinoma 10.4 PGR MUC1
48 lipid-rich breast carcinoma 10.3 PGR MUC1
49 anal neuroendocrine tumor 10.3 SYP ENO2
50 glomangiomatosis 10.3 SYP CHGA

Graphical network of the top 20 diseases related to Sclerosing Hemangioma:



Diseases related to Sclerosing Hemangioma

Symptoms & Phenotypes for Sclerosing Hemangioma

Drugs & Therapeutics for Sclerosing Hemangioma

Drugs for Sclerosing Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 1 51-21-8 3385
2
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
3
Belinostat Approved, Investigational Phase 1 866323-14-0
4 Immunologic Factors Phase 1
5 Histone Deacetylase Inhibitors Phase 1
6 Androgens Phase 1
7 Immunosuppressive Agents Phase 1
8 Antimetabolites Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I Safety, Pharmacodynamic, Anti-Tumor Activity, and Pharmacokinetic Study of PXD101 Alone and in Combination With 5-Fluorouracil in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)

Search NIH Clinical Center for Sclerosing Hemangioma

Genetic Tests for Sclerosing Hemangioma

Anatomical Context for Sclerosing Hemangioma

MalaCards organs/tissues related to Sclerosing Hemangioma:

40
Lung, Skin, Liver, Lymph Node, Thyroid, Breast, Endothelial

Publications for Sclerosing Hemangioma

Articles related to Sclerosing Hemangioma:

(show top 50) (show all 375)
# Title Authors PMID Year
1
Multiple sclerosing hemangioma of the right lung in a 23-year-old female patient: A case report and review of the literature. 61
32064104 2020
2
Identification of the BRAF V600E mutation in a patient with sclerosing pneumocytoma: A case report. 61
31546071 2019
3
Symptomatic pulmonary sclerosing hemangioma: a rare case of a solitary pulmonary nodule in a woman of advanced age. 61
30971157 2019
4
A hepatic sclerosing hemangioma emerged in the postoperative course of multiple gastric carcinoid tumors masquerading as metachronous liver metastasis. 61
30986640 2019
5
Resection as first-line therapy for large hepatic sclerosing hemangioma: a case report. 61
31692527 2019
6
Hepatic Sclerosing Hemangioma Simulating Gallbladder Carcinoma: A Rare Case. 61
30564006 2018
7
A Challenge: Pulmonary Sclerosing Haemangioma. 61
30147108 2018
8
18F-FDG PET/CT characteristics of pulmonary sclerosing hemangioma vs. pulmonary hamartoma. 61
29930720 2018
9
Multiple hepatic sclerosing hemangiomas: a case report and review of the literature. 61
29916092 2018
10
IgG4-Associated Cholangitis in Patients Resected for Presumed Perihilar Cholangiocarcinoma: a 30-Year Tertiary Care Experience. 61
29549357 2018
11
Hepatic Sclerosing Hemangioma with Predominance of the Sclerosed Area Mimicking a Biliary Cystadenocarcinoma. 61
30402303 2018
12
Pneumocytoma (sclerosing hemangioma), a potential pitfall. 61
28398699 2017
13
Pulmonary sclerosing hemangioma with a rare symptom: A case report and review of the literature. 61
28357098 2017
14
Peritumoral Hyperplasia in Hepatic Sclerosed Hemangioma. 61
28462238 2017
15
Sclerosing Pneumocytoma: a Carcinoma Mimicker. A Case Report and Literature Review. 61
28249927 2017
16
Pulmonary sclerosing pneumocytoma (sclerosing haemangioma): Radical radiation therapy. 61
27302690 2016
17
Whole-exome sequencing identifies recurrent AKT1 mutations in sclerosing hemangioma of lung. 61
27601661 2016
18
Sclerosing Angiomatoid Nodular Transformation of the spleen, focal nodular hyperplasia and hemangioma of the liver: A tale of three lesions. 61
27450658 2016
19
Ectopic ACTH syndrome caused by pulmonary carcinoid tumor mimicking long-standing sclerosing hemangioma. 61
26828249 2016
20
Clinical case report: Sclerosing hemangioma of the liver, a rare but great mimicker. 61
27257450 2016
21
Preoperative Diagnosis in 46 Cases of Pulmonary Sclerosing Hemangioma. 61
27231179 2016
22
Pulmonary Hilar Tumor: An Unusual Presentation of Sclerosing Hemangioma. 61
27761142 2016
23
Sclerosing hemangioma: A diagnostic dilemma in fine needle aspiration cytology. 61
27168758 2016
24
Co-occurrence of bronchial papilloma and pulmonary sclerosing hemangioma in a male. 61
27812454 2016
25
CTNNB1 (β-Catenin)-altered Neoplasia: A Review Focusing on Soft Tissue Neoplasms and Parenchymal Lesions of Uncertain Histogenesis. 61
26645457 2016
26
Sclerosing hemangioma of the lung showing strong FDG avidity on PET scan: Case report and review of the current literature. 61
27222778 2016
27
Pitfalls and Key Features of a Case of Sclerosing Pneumocytoma: A Cytological Challenge? 61
26934286 2016
28
The role of video-assisted thoracoscopic surgery in management of the multiple ground-glass nodules. 61
26728679 2015
29
Bone metastasis in pulmonary sclerosing hemangioma. 61
26552471 2015
30
The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification. 61
26291008 2015
31
Video-assisted thoracoscopic enucleation after congenital cardiac surgery. 61
26385193 2015
32
Sclerosing hemangioma of the lung mimicking pulmonary metastasis. 61
25762452 2015
33
Incidental finding of a sclerosing hemangioma in a Caucasian woman. 61
26193226 2015
34
Sclerosing hemangioma of the lung. 61
26223076 2015
35
Multiple hepatic sclerosing hemangioma mimicking metastatic liver tumor successfully treated by laparoscopic surgery: Report of a case. 61
25679307 2015
36
[Case Report; A case of pulmonary sclerosing hemangioma in a young male]. 61
26571782 2015
37
A surgically treated pulmonary sclerosing haemangioma that clinically and radiologically mimicked a thrombosed pulmonary artery aneurysm. 61
25519861 2014
38
[Bronchial glomus tumor: report of 2 cases and review of the literature]. 61
25537412 2014
39
Primary hepatic vascular tumours. A clinicopathologic study of 10 cases. 61
25509207 2014
40
The significance of p40 expression in sclerosing hemangioma of lung. 61
25130377 2014
41
Unusual coexistence of pulmonary sclerosing hemangioma and pericardial cyst. 61
24887810 2014
42
Multiple pulmonary sclerosing hemangiomas (pneumocytoma) mimicking lung metastasis detected in fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography. 61
25210285 2014
43
Histogenesis of pulmonary sclerosing hemangioma and significance of P63 expression. 61
23910931 2014
44
Pulmonary sclerosing hemangioma with lymph node metastasis: A case report and literature review. 61
24944657 2014
45
Fine-needle aspiration diagnosis of sclerosing hemangioma (pneumocytoma): report of a case and review of the literature. 61
22645055 2014
46
Solitary Necrotic Nodule of Liver (SNNL): A Report of Two Cases. 61
24783098 2014
47
Cavernous hemangioma with extensive sclerosis masquerading as intrahepatic cholangiocarcinoma - A pathologist's perspective. 61
27186246 2014
48
A sclerosing hemangioma of the liver. 61
24459649 2013
49
[Pulmonary sclerosing hemangioma with lymph node metastasis]. 61
24322353 2013
50
Diagnostic value of endobronchial ultrasound-guided transbronchial needle aspiration in intrapulmonary lesions. 61
24238520 2013

Variations for Sclerosing Hemangioma

Expression for Sclerosing Hemangioma

Search GEO for disease gene expression data for Sclerosing Hemangioma.

Pathways for Sclerosing Hemangioma

Pathways related to Sclerosing Hemangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 SYP NKX2-1 ENO2 CALCA

GO Terms for Sclerosing Hemangioma

Cellular components related to Sclerosing Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 SFTPB MUC1 GAST ENO2 CHGA CALCA

Biological processes related to Sclerosing Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vasculature development GO:0001944 9.16 CTNNB1 CALCA
2 negative regulation of osteoclast differentiation GO:0045671 8.96 CTNNB1 CALCA
3 epithelial tube branching involved in lung morphogenesis GO:0060441 8.62 NKX2-1 CTNNB1

Sources for Sclerosing Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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