MCID: SCL007
MIFTS: 28

Sclerosing Hepatic Carcinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Sclerosing Hepatic Carcinoma

MalaCards integrated aliases for Sclerosing Hepatic Carcinoma:

Name: Sclerosing Hepatic Carcinoma 12 15
Sclerosing Hepatocellular Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5026
NCIt 49 C27388
UMLS 71 C1266018

Summaries for Sclerosing Hepatic Carcinoma

MalaCards based summary : Sclerosing Hepatic Carcinoma, also known as sclerosing hepatocellular carcinoma, is related to intrahepatic cholangiocarcinoma and fibrolamellar carcinoma. An important gene associated with Sclerosing Hepatic Carcinoma is SHC3 (SHC Adaptor Protein 3), and among its related pathways/superpathways are Hematopoietic cell lineage and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include liver, breast and colon, and related phenotypes are Reduced mammosphere formation and cellular

Related Diseases for Sclerosing Hepatic Carcinoma

Diseases related to Sclerosing Hepatic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 intrahepatic cholangiocarcinoma 30.3 KRT19 GPC3 AFP
2 fibrolamellar carcinoma 30.1 KRT19 GPC3 AFP
3 cholangiocarcinoma 29.6 MME KRT19 GPC3 AFP
4 giant hemangioma 10.5 SHC3 AFP
5 ovarian embryonal carcinoma 10.4 GPC3 AFP
6 dysgerminoma of ovary 10.4 PTHLH AFP
7 ovarian primitive germ cell tumor 10.4 GPC3 AFP
8 ovarian endodermal sinus tumor 10.4 GPC3 AFP
9 testicular malignant germ cell cancer 10.4 GPC3 AFP
10 ovarian gonadoblastoma 10.4 GPC3 AFP
11 intrahepatic bile duct adenoma 10.4 KRT19 AFP
12 infected hydrocele 10.4 CD79A AFP
13 renal pelvis adenocarcinoma 10.4 KRT19 AFP
14 mixed hepatoblastoma 10.4 CHGA AFP
15 ovarian germ cell teratoma 10.4 KRT19 AFP
16 testicular yolk sac tumor 10.4 GPC3 AFP
17 paratesticular lipoma 10.4 KRT19 AFP
18 lipoma of spermatic cord 10.4 KRT19 AFP
19 hepatoid adenocarcinoma 10.4 GPC3 AFP
20 adult teratoma 10.3 CHGA AFP
21 thymus sarcomatoid carcinoma 10.3 CD5 AFP
22 hepatocellular carcinoma 10.3
23 ovarian germ cell cancer 10.3 GPC3 AFP
24 endometrial small cell carcinoma 10.3 CHGA AFP
25 simpson-golabi-behmel syndrome, type 1 10.3 GPC3 AFP
26 acinar cell cystadenocarcinoma 10.3 KRT19 CHGA
27 middle ear carcinoma 10.3 CHGA AFP
28 ovarian solid teratoma 10.3 CD34 AFP
29 liver inflammatory pseudotumor 10.3 CD34 AFP
30 papillary adenofibroma 10.3 CD34 AFP
31 chorioangioma 10.3 CD34 AFP
32 colonic lymphangioma 10.3 CD34 AFP
33 liver sarcoma 10.3 CD34 AFP
34 benign mesothelioma 10.3 CD34 AFP
35 peliosis hepatis 10.2 CD34 AFP
36 papillary thymic adenocarcinoma 10.2 CHGA CD5
37 breast hemangiopericytoma 10.2 KRT19 CD34
38 clear cell basal cell carcinoma 10.2 KRT19 CHGA
39 epididymal neoplasm 10.2 MME AFP
40 cystic lymphangioma 10.2 CD34 AFP
41 pancreatic endocrine carcinoma 10.2 PTHLH CHGA AFP
42 hilar lung carcinoma 10.2 MME CD79A
43 appendix lymphoma 10.2 CHGA CD5
44 lung hilum cancer 10.2 MME CD79A
45 cystadenofibroma 10.2 MME AFP
46 microcystic adenoma 10.2 KRT19 CHGA
47 cutaneous ganglioneuroma 10.2 CHGA CD34
48 epididymis adenocarcinoma 10.2 MME AFP
49 epididymis cancer 10.1 MME AFP
50 bile duct adenocarcinoma 10.1 KRT19 GPC3 AFP

Graphical network of the top 20 diseases related to Sclerosing Hepatic Carcinoma:



Diseases related to Sclerosing Hepatic Carcinoma

Symptoms & Phenotypes for Sclerosing Hepatic Carcinoma

GenomeRNAi Phenotypes related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 AFP CD34 CD5 CD79A CHGA SHC1

MGI Mouse Phenotypes related to Sclerosing Hepatic Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.06 CD34 CD79A GPC3 HSPA4 KRT19 MME
2 immune system MP:0005387 9.97 CD34 CD5 CD79A GPC3 KRT19 MME
3 endocrine/exocrine gland MP:0005379 9.91 AFP CHGA HSPA4 KRT19 PTH PTHLH
4 integument MP:0010771 9.8 CD34 CD5 GPC3 KRT19 MME PTHLH
5 neoplasm MP:0002006 9.63 AFP CD34 CD79A KRT19 PTHLH SHC1
6 nervous system MP:0003631 9.61 CD5 CD79A CHGA HSPA4 KRT19 MME
7 reproductive system MP:0005389 9.17 AFP CHGA GPC3 HSPA4 KRT19 PTHLH

Drugs & Therapeutics for Sclerosing Hepatic Carcinoma

Search Clinical Trials , NIH Clinical Center for Sclerosing Hepatic Carcinoma

Genetic Tests for Sclerosing Hepatic Carcinoma

Anatomical Context for Sclerosing Hepatic Carcinoma

MalaCards organs/tissues related to Sclerosing Hepatic Carcinoma:

40
Liver, Breast, Colon, Lung, B Cells, Bone, Thymus

Publications for Sclerosing Hepatic Carcinoma

Articles related to Sclerosing Hepatic Carcinoma:

(show all 18)
# Title Authors PMID Year
1
Hemodynamics of small sclerosing hepatocellular carcinoma without fibrous capsule: evaluation with single-level dynamic CT during hepatic arteriography. 61
17657527 2008
2
Sclerosing hepatic carcinoma: helical CT features. 61
17203330 2007
3
[Surgical treatment of sclerosing hepatocellular carcinoma]. 61
16998293 2006
4
Sclerosing hepatocellular carcinoma: clinicopathologic features in seven patients from Taiwan and review of the literature. 61
16001661 2005
5
In situ demonstration of parathyroid hormone-related protein mRNA in sclerosing hepatic carcinoma. 61
10599313 1999
6
Sclerosing hepatic carcinoma in non-cirrhotic liver resembling metastatic adenocarcinoma. 61
9927164 1999
7
[Sclerosing hepatocarcinoma not associated with hypercalcemia]. 61
9445545 1997
8
[Sclerosing hepatocellular carcinoma with rapid course]. 61
9471209 1997
9
Immunohistochemical detection of parathyroid hormone-related protein in a rare variant of hepatic neoplasm (sclerosing hepatic carcinoma). 61
8698319 1996
10
[Hepatic metastases of pancreatic gastrinoma associated with sclerosing hepatocellular carcinoma]. 61
8642778 1996
11
[Sclerosing hepatic carcinoma]. 61
8749527 1995
12
Sclerosing hepatocellular carcinoma: radiologic findings. 61
8220034 1993
13
Computed tomography of sclerosing hepatocellular carcinoma. 61
1373669 1992
14
Sclerosing hepatocellular carcinoma with hypercalcemia--a case report. 61
1328759 1992
15
[A histopathologic comparative study of European cases of fibrolamellar carcinoma and Japanese cases of sclerosing hepatocellular carcinoma]. 61
2544750 1989
16
[A case of sclerosing hepatic carcinoma which showed hypercalcemia and responded to various therapeutic modalities]. 61
3599507 1987
17
Sclerosing hepatic carcinoma: a report of a case treated with a transcatheter arterial embolization. 61
6522635 1984
18
Sclerosing hepatic carcinoma: relationship to hypercalcemia. 61
6294435 1981

Variations for Sclerosing Hepatic Carcinoma

Expression for Sclerosing Hepatic Carcinoma

Search GEO for disease gene expression data for Sclerosing Hepatic Carcinoma.

Pathways for Sclerosing Hepatic Carcinoma

Pathways related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 MME CD5 CD34
2 10.99 MME CD79A CD5 CD34
3 10.86 MME CD5 CD34

GO Terms for Sclerosing Hepatic Carcinoma

Biological processes related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of chondrocyte differentiation GO:0032331 8.96 PTHLH PTH
2 cAMP metabolic process GO:0046058 8.62 PTHLH PTH

Molecular functions related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.62 PTHLH PTH

Sources for Sclerosing Hepatic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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