MCID: SCL007
MIFTS: 27

Sclerosing Hepatic Carcinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Sclerosing Hepatic Carcinoma

MalaCards integrated aliases for Sclerosing Hepatic Carcinoma:

Name: Sclerosing Hepatic Carcinoma 12 15
Sclerosing Hepatocellular Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5026
NCIt 51 C27388
UMLS 74 C1266018

Summaries for Sclerosing Hepatic Carcinoma

MalaCards based summary : Sclerosing Hepatic Carcinoma, also known as sclerosing hepatocellular carcinoma, is related to hepatocellular carcinoma and islet cell tumor. An important gene associated with Sclerosing Hepatic Carcinoma is PTHLH (Parathyroid Hormone Like Hormone), and among its related pathways/superpathways are G alpha (s) signalling events and Parathyroid hormone synthesis, secretion and action. Affiliated tissues include liver, bone and ovary, and related phenotype is endocrine/exocrine gland.

Related Diseases for Sclerosing Hepatic Carcinoma

Diseases related to Sclerosing Hepatic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 hepatocellular carcinoma 10.3
2 islet cell tumor 10.0 CHGA PTHLH
3 chorioangioma 10.0 AFP PTHLH
4 sarcomatous intrahepatic cholangiocarcinoma 10.0 AFP SHC3
5 hemangioma of intra-abdominal structure 10.0 AFP PTHLH
6 adult teratoma 10.0 AFP CHGA
7 pancreatic acinar cell adenocarcinoma 10.0 AFP CHGA
8 leydig cell tumor 10.0 AFP PTHLH
9 pancreatoblastoma 10.0 AFP CHGA
10 dysgerminoma of ovary 10.0 AFP PTHLH
11 endodermal sinus tumor 10.0 AFP CHGA
12 dysgerminoma 10.0 AFP PTHLH
13 acinar cell carcinoma 10.0 AFP CHGA
14 tubular adenocarcinoma 10.0 AFP CHGA
15 large cell carcinoma 10.0 CHGA PTHLH
16 extraskeletal chondroma 9.9 PTH PTHLH
17 invasive malignant thymoma 9.9 PTH PTHLH
18 hypocalciuric hypercalcemia, familial, type iii 9.9 PTH PTHLH
19 clear cell adenoma 9.9 PTH PTHLH
20 oncogenic osteomalacia 9.9 PTH PTHLH
21 hypercalcemia, infantile, 1 9.9 PTH PTHLH
22 cloacogenic carcinoma 9.9 PTH PTHLH
23 metaphyseal chondrodysplasia, jansen type 9.9 PTH PTHLH
24 parathyroid gland disease 9.9 PTH PTHLH
25 pseudohypoparathyroidism 9.8 PTH PTHLH
26 adenocarcinoma 9.8
27 pseudohypoparathyroidism, type ib 9.8 PTH PTHLH
28 hypoparathyroidism 9.8 PTH PTHLH
29 mineral metabolism disease 9.8 PTH PTHLH
30 liver sarcoma 9.8 AFP CHGA PTHLH
31 endocrine organ benign neoplasm 9.8 CHGA PTH
32 endocrine gland cancer 9.7 AFP CHGA
33 cell type benign neoplasm 9.7 CHGA PTH
34 multiple endocrine neoplasia, type i 9.7 CHGA PTH
35 parathyroid adenoma 9.6 CHGA PTH PTHLH
36 primary hyperparathyroidism 9.6 CHGA PTH PTHLH
37 hyperparathyroidism 9.6 CHGA PTH PTHLH
38 bone disease 9.5 PTH PTHLH

Graphical network of the top 20 diseases related to Sclerosing Hepatic Carcinoma:



Diseases related to Sclerosing Hepatic Carcinoma

Symptoms & Phenotypes for Sclerosing Hepatic Carcinoma

MGI Mouse Phenotypes related to Sclerosing Hepatic Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 8.92 AFP CHGA PTH PTHLH

Drugs & Therapeutics for Sclerosing Hepatic Carcinoma

Search Clinical Trials , NIH Clinical Center for Sclerosing Hepatic Carcinoma

Genetic Tests for Sclerosing Hepatic Carcinoma

Anatomical Context for Sclerosing Hepatic Carcinoma

MalaCards organs/tissues related to Sclerosing Hepatic Carcinoma:

42
Liver, Bone, Ovary

Publications for Sclerosing Hepatic Carcinoma

Articles related to Sclerosing Hepatic Carcinoma:

(show all 11)
# Title Authors Year
1
Hemodynamics of small sclerosing hepatocellular carcinoma without fibrous capsule: evaluation with single-level dynamic CT during hepatic arteriography. ( 17657527 )
2008
2
Sclerosing hepatic carcinoma: helical CT features. ( 17203330 )
2007
3
Sclerosing hepatocellular carcinoma: clinicopathologic features in seven patients from Taiwan and review of the literature. ( 16001661 )
2005
4
Sclerosing hepatic carcinoma in non-cirrhotic liver resembling metastatic adenocarcinoma. ( 9927164 )
1999
5
In situ demonstration of parathyroid hormone-related protein mRNA in sclerosing hepatic carcinoma. ( 10599313 )
1999
6
Immunohistochemical detection of parathyroid hormone-related protein in a rare variant of hepatic neoplasm (sclerosing hepatic carcinoma). ( 8698319 )
1996
7
Sclerosing hepatocellular carcinoma: radiologic findings. ( 8220034 )
1993
8
Sclerosing hepatocellular carcinoma with hypercalcemia--a case report. ( 1328759 )
1992
9
Computed tomography of sclerosing hepatocellular carcinoma. ( 1373669 )
1992
10
Sclerosing hepatic carcinoma: a report of a case treated with a transcatheter arterial embolization. ( 6522635 )
1984
11
Sclerosing hepatic carcinoma: relationship to hypercalcemia. ( 6294435 )
1981

Variations for Sclerosing Hepatic Carcinoma

Expression for Sclerosing Hepatic Carcinoma

Search GEO for disease gene expression data for Sclerosing Hepatic Carcinoma.

Pathways for Sclerosing Hepatic Carcinoma

Pathways related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.42 PTH PTHLH
2 11.18 PTH PTHLH
3 10.77 PTH PTHLH
4 10.21 PTH PTHLH

GO Terms for Sclerosing Hepatic Carcinoma

Cellular components related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 AFP CHGA PTH PTHLH
2 extracellular space GO:0005615 8.92 AFP CHGA PTH PTHLH

Biological processes related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.32 PTH PTHLH
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.26 PTH PTHLH
3 negative regulation of chondrocyte differentiation GO:0032331 8.96 PTH PTHLH
4 bone mineralization GO:0030282 8.85 PTHLH
5 cAMP metabolic process GO:0046058 8.62 PTH PTHLH

Molecular functions related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 PTH PTHLH
2 peptide hormone receptor binding GO:0051428 8.62 PTH PTHLH

Sources for Sclerosing Hepatic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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