MCID: SCL007
MIFTS: 24

Sclerosing Hepatic Carcinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Sclerosing Hepatic Carcinoma

MalaCards integrated aliases for Sclerosing Hepatic Carcinoma:

Name: Sclerosing Hepatic Carcinoma 12 15
Sclerosing Hepatocellular Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5026
NCIt 50 C27388
UMLS 72 C1266018

Summaries for Sclerosing Hepatic Carcinoma

MalaCards based summary : Sclerosing Hepatic Carcinoma, also known as sclerosing hepatocellular carcinoma, is related to hepatocellular carcinoma and chorioangioma. An important gene associated with Sclerosing Hepatic Carcinoma is PTHLH (Parathyroid Hormone Like Hormone), and among its related pathways/superpathways are Parathyroid hormone synthesis, secretion and action and Bacterial invasion of epithelial cells. Affiliated tissues include liver, and related phenotype is endocrine/exocrine gland.

Related Diseases for Sclerosing Hepatic Carcinoma

Diseases related to Sclerosing Hepatic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 hepatocellular carcinoma 10.3
2 chorioangioma 10.3 PTHLH AFP
3 hemangioma of intra-abdominal structure 10.2 PTHLH AFP
4 leydig cell tumor 10.2 PTHLH AFP
5 dysgerminoma 10.2 PTHLH AFP
6 adult teratoma 10.2 CHGA AFP
7 dysgerminoma of ovary 10.2 PTHLH AFP
8 pancreatic acinar cell adenocarcinoma 10.2 CHGA AFP
9 pancreatoblastoma 10.2 CHGA AFP
10 endodermal sinus tumor 10.1 CHGA AFP
11 extraskeletal chondroma 10.1 PTHLH PTH
12 invasive malignant thymoma 10.1 PTHLH PTH
13 acinar cell carcinoma 10.1 CHGA AFP
14 hypocalciuric hypercalcemia, familial, type iii 10.1 PTHLH PTH
15 clear cell adenoma 10.1 PTHLH PTH
16 tubular adenocarcinoma 10.1 CHGA AFP
17 oncogenic osteomalacia 10.1 PTHLH PTH
18 islet cell tumor 10.1 PTHLH CHGA
19 hypercalcemia, infantile, 1 10.1 PTHLH PTH
20 cloacogenic carcinoma 10.1 PTHLH PTH
21 metaphyseal chondrodysplasia, jansen type 10.0 PTHLH PTH
22 cholangiocarcinoma 10.0
23 adenocarcinoma 10.0
24 intrahepatic cholangiocarcinoma 10.0
25 parathyroid gland disease 10.0 PTHLH PTH
26 pseudohypoparathyroidism, type ib 10.0 PTHLH PTH
27 pseudohypoparathyroidism 10.0 PTHLH PTH
28 large cell carcinoma 10.0 PTHLH CHGA
29 hypoparathyroidism 10.0 PTHLH PTH
30 mineral metabolism disease 9.9 PTHLH PTH
31 zollinger-ellison syndrome 9.9
32 fibrolamellar carcinoma 9.9
33 gastrinoma 9.9
34 pancreatic gastrinoma 9.9
35 acute sensory ataxic neuropathy 9.9
36 sarcomatous intrahepatic cholangiocarcinoma 9.9 SHC3 AFP
37 liver cirrhosis 9.9
38 cholangiolocellular carcinoma 9.9
39 liver sarcoma 9.8 PTHLH CHGA AFP
40 endocrine organ benign neoplasm 9.8 PTH CHGA
41 cell type benign neoplasm 9.7 PTH CHGA
42 endocrine gland cancer 9.7 CHGA AFP
43 multiple endocrine neoplasia, type i 9.7 PTH CHGA
44 parathyroid adenoma 9.7 PTHLH PTH CHGA
45 primary hyperparathyroidism 9.7 PTHLH PTH CHGA
46 hyperparathyroidism 9.6 PTHLH PTH CHGA
47 thyroid carcinoma, familial medullary 9.5 SHC1 CHGA

Graphical network of the top 20 diseases related to Sclerosing Hepatic Carcinoma:



Diseases related to Sclerosing Hepatic Carcinoma

Symptoms & Phenotypes for Sclerosing Hepatic Carcinoma

MGI Mouse Phenotypes related to Sclerosing Hepatic Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.02 AFP CHGA PTH PTHLH SHC1

Drugs & Therapeutics for Sclerosing Hepatic Carcinoma

Search Clinical Trials , NIH Clinical Center for Sclerosing Hepatic Carcinoma

Genetic Tests for Sclerosing Hepatic Carcinoma

Anatomical Context for Sclerosing Hepatic Carcinoma

MalaCards organs/tissues related to Sclerosing Hepatic Carcinoma:

41
Liver

Publications for Sclerosing Hepatic Carcinoma

Articles related to Sclerosing Hepatic Carcinoma:

(show all 18)
# Title Authors PMID Year
1
Hemodynamics of small sclerosing hepatocellular carcinoma without fibrous capsule: evaluation with single-level dynamic CT during hepatic arteriography. 38
17657527 2008
2
Sclerosing hepatic carcinoma: helical CT features. 38
17203330 2007
3
[Surgical treatment of sclerosing hepatocellular carcinoma]. 38
16998293 2006
4
Sclerosing hepatocellular carcinoma: clinicopathologic features in seven patients from Taiwan and review of the literature. 38
16001661 2005
5
In situ demonstration of parathyroid hormone-related protein mRNA in sclerosing hepatic carcinoma. 38
10599313 1999
6
Sclerosing hepatic carcinoma in non-cirrhotic liver resembling metastatic adenocarcinoma. 38
9927164 1999
7
[Sclerosing hepatocarcinoma not associated with hypercalcemia]. 38
9445545 1997
8
[Sclerosing hepatocellular carcinoma with rapid course]. 38
9471209 1997
9
Immunohistochemical detection of parathyroid hormone-related protein in a rare variant of hepatic neoplasm (sclerosing hepatic carcinoma). 38
8698319 1996
10
[Hepatic metastases of pancreatic gastrinoma associated with sclerosing hepatocellular carcinoma]. 38
8642778 1996
11
[Sclerosing hepatic carcinoma]. 38
8749527 1995
12
Sclerosing hepatocellular carcinoma: radiologic findings. 38
8220034 1993
13
Computed tomography of sclerosing hepatocellular carcinoma. 38
1373669 1992
14
Sclerosing hepatocellular carcinoma with hypercalcemia--a case report. 38
1328759 1992
15
[A histopathologic comparative study of European cases of fibrolamellar carcinoma and Japanese cases of sclerosing hepatocellular carcinoma]. 38
2544750 1989
16
[A case of sclerosing hepatic carcinoma which showed hypercalcemia and responded to various therapeutic modalities]. 38
3599507 1987
17
Sclerosing hepatic carcinoma: a report of a case treated with a transcatheter arterial embolization. 38
6522635 1984
18
Sclerosing hepatic carcinoma: relationship to hypercalcemia. 38
6294435 1981

Variations for Sclerosing Hepatic Carcinoma

Expression for Sclerosing Hepatic Carcinoma

Search GEO for disease gene expression data for Sclerosing Hepatic Carcinoma.

Pathways for Sclerosing Hepatic Carcinoma

Pathways related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.35 PTHLH PTH
2 11.12 SHC3 SHC1
3 10.97 PTHLH PTH
4
Show member pathways
10.74 SHC3 SHC1
5 10.21 PTHLH PTH

GO Terms for Sclerosing Hepatic Carcinoma

Cellular components related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 PTHLH PTH CHGA AFP

Biological processes related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.37 PTHLH PTH
2 Ras protein signal transduction GO:0007265 9.32 SHC3 SHC1
3 epidermal growth factor receptor signaling pathway GO:0007173 9.26 SHC3 SHC1
4 negative regulation of chondrocyte differentiation GO:0032331 8.96 PTHLH PTH
5 bone mineralization GO:0030282 8.85 PTHLH
6 cAMP metabolic process GO:0046058 8.62 PTHLH PTH

Molecular functions related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.26 PTHLH PTH
2 receptor tyrosine kinase binding GO:0030971 9.16 SHC3 SHC1
3 phosphotyrosine residue binding GO:0001784 8.96 SHC3 SHC1
4 peptide hormone receptor binding GO:0051428 8.62 PTHLH PTH

Sources for Sclerosing Hepatic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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