MCID: SCL007
MIFTS: 25

Sclerosing Hepatic Carcinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Sclerosing Hepatic Carcinoma

MalaCards integrated aliases for Sclerosing Hepatic Carcinoma:

Name: Sclerosing Hepatic Carcinoma 12 15
Sclerosing Hepatocellular Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5026
NCIt 50 C27388
SNOMED-CT 68 128646008
UMLS 73 C1266018

Summaries for Sclerosing Hepatic Carcinoma

MalaCards based summary : Sclerosing Hepatic Carcinoma, also known as sclerosing hepatocellular carcinoma, is related to chorioangioma and hemangioma of intra-abdominal structure. An important gene associated with Sclerosing Hepatic Carcinoma is PTHLH (Parathyroid Hormone Like Hormone), and among its related pathways/superpathways are G alpha (s) signalling events and Parathyroid hormone synthesis, secretion and action. Affiliated tissues include liver, and related phenotype is endocrine/exocrine gland.

Related Diseases for Sclerosing Hepatic Carcinoma

Diseases related to Sclerosing Hepatic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 chorioangioma 10.2 AFP PTHLH
2 hemangioma of intra-abdominal structure 10.2 AFP PTHLH
3 dysgerminoma of ovary 10.2 AFP PTHLH
4 leydig cell tumor 10.1 AFP PTHLH
5 hepatitis 10.1
6 adult teratoma 10.1 AFP CHGA
7 pancreatic acinar cell adenocarcinoma 10.0 AFP CHGA
8 pancreatoblastoma 10.0 AFP CHGA
9 islet cell tumor 10.0 CHGA PTHLH
10 pancreatic cystadenocarcinoma 10.0 AFP CHGA
11 endodermal sinus tumor 10.0 AFP CHGA
12 tubular adenocarcinoma 9.9 AFP CHGA
13 extraskeletal chondroma 9.9 PTH PTHLH
14 invasive malignant thymoma 9.9 PTH PTHLH
15 acinar cell carcinoma 9.9 AFP CHGA
16 hypocalciuric hypercalcemia, familial, type iii 9.9 PTH PTHLH
17 clear cell adenoma 9.9 PTH PTHLH
18 large cell carcinoma 9.9 CHGA PTHLH
19 oncogenic osteomalacia 9.9 PTH PTHLH
20 hypercalcemia, infantile, 1 9.9 PTH PTHLH
21 jaw cancer 9.8 PTH PTHLH
22 pseudohypoparathyroidism, type ib 9.8 PTH PTHLH
23 cloacogenic carcinoma 9.8 PTH PTHLH
24 metaphyseal chondrodysplasia, jansen type 9.8 PTH PTHLH
25 adenocarcinoma 9.7
26 parathyroid gland disease 9.7 PTH PTHLH
27 mineral metabolism disease 9.7 PTH PTHLH
28 cell type cancer 9.7 AFP CHGA
29 pseudohypoparathyroidism 9.7 PTH PTHLH
30 hypoparathyroidism 9.6 PTH PTHLH
31 liver sarcoma 9.5 AFP CHGA PTHLH
32 acquired metabolic disease 9.4 PTH PTHLH
33 cell type benign neoplasm 9.4 CHGA PTH
34 parathyroid adenoma 9.2 CHGA PTH PTHLH
35 primary hyperparathyroidism 9.2 CHGA PTH PTHLH
36 hyperparathyroidism 9.2 CHGA PTH PTHLH
37 multiple endocrine neoplasia, type i 9.1 CHGA PTH
38 bone disease 9.1 PTH PTHLH

Graphical network of the top 20 diseases related to Sclerosing Hepatic Carcinoma:



Diseases related to Sclerosing Hepatic Carcinoma

Symptoms & Phenotypes for Sclerosing Hepatic Carcinoma

MGI Mouse Phenotypes related to Sclerosing Hepatic Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 8.92 AFP CHGA PTH PTHLH

Drugs & Therapeutics for Sclerosing Hepatic Carcinoma

Search Clinical Trials , NIH Clinical Center for Sclerosing Hepatic Carcinoma

Genetic Tests for Sclerosing Hepatic Carcinoma

Anatomical Context for Sclerosing Hepatic Carcinoma

MalaCards organs/tissues related to Sclerosing Hepatic Carcinoma:

41
Liver

Publications for Sclerosing Hepatic Carcinoma

Articles related to Sclerosing Hepatic Carcinoma:

# Title Authors Year
1
Sclerosing hepatic carcinoma: helical CT features. ( 17203330 )
2007
2
In situ demonstration of parathyroid hormone-related protein mRNA in sclerosing hepatic carcinoma. ( 10599313 )
1999
3
Sclerosing hepatic carcinoma in non-cirrhotic liver resembling metastatic adenocarcinoma. ( 9927164 )
1999
4
Immunohistochemical detection of parathyroid hormone-related protein in a rare variant of hepatic neoplasm (sclerosing hepatic carcinoma). ( 8698319 )
1996
5
Sclerosing hepatic carcinoma: a report of a case treated with a transcatheter arterial embolization. ( 6522635 )
1984
6
Sclerosing hepatic carcinoma: relationship to hypercalcemia. ( 6294435 )
1981

Variations for Sclerosing Hepatic Carcinoma

Expression for Sclerosing Hepatic Carcinoma

Search GEO for disease gene expression data for Sclerosing Hepatic Carcinoma.

Pathways for Sclerosing Hepatic Carcinoma

Pathways related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.42 PTH PTHLH
2 11.18 PTH PTHLH
3 10.77 PTH PTHLH
4 10.21 PTH PTHLH

GO Terms for Sclerosing Hepatic Carcinoma

Cellular components related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 AFP CHGA PTH PTHLH
2 extracellular space GO:0005615 8.92 AFP CHGA PTH PTHLH

Biological processes related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.32 PTH PTHLH
2 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.26 PTH PTHLH
3 negative regulation of chondrocyte differentiation GO:0032331 9.16 PTH PTHLH
4 obsolete positive regulation of cAMP biosynthetic process GO:0030819 8.96 PTH PTHLH
5 cAMP metabolic process GO:0046058 8.62 PTH PTHLH

Molecular functions related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 PTH PTHLH
2 peptide hormone receptor binding GO:0051428 8.62 PTH PTHLH

Sources for Sclerosing Hepatic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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