MCID: SCL007
MIFTS: 27

Sclerosing Hepatic Carcinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Sclerosing Hepatic Carcinoma

MalaCards integrated aliases for Sclerosing Hepatic Carcinoma:

Name: Sclerosing Hepatic Carcinoma 12 15
Sclerosing Hepatocellular Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5026
NCIt 50 C27388
UMLS 73 C1266018

Summaries for Sclerosing Hepatic Carcinoma

MalaCards based summary : Sclerosing Hepatic Carcinoma, also known as sclerosing hepatocellular carcinoma, is related to hepatocellular carcinoma and chorioangioma. An important gene associated with Sclerosing Hepatic Carcinoma is PTHLH (Parathyroid Hormone Like Hormone), and among its related pathways/superpathways are G alpha (s) signalling events and Parathyroid hormone synthesis, secretion and action. Affiliated tissues include liver, bone and ovary, and related phenotype is endocrine/exocrine gland.

Related Diseases for Sclerosing Hepatic Carcinoma

Diseases related to Sclerosing Hepatic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 hepatocellular carcinoma 10.3
2 chorioangioma 10.1 AFP PTHLH
3 sarcomatous intrahepatic cholangiocarcinoma 10.1 AFP SHC3
4 hemangioma of intra-abdominal structure 10.1 AFP PTHLH
5 leydig cell tumor 10.0 AFP PTHLH
6 dysgerminoma of ovary 10.0 AFP PTHLH
7 dysgerminoma 10.0 AFP PTHLH
8 adult teratoma 10.0 AFP CHGA
9 pancreatic acinar cell adenocarcinoma 10.0 AFP CHGA
10 pancreatoblastoma 10.0 AFP CHGA
11 endodermal sinus tumor 10.0 AFP CHGA
12 islet cell tumor 10.0 CHGA PTHLH
13 acinar cell carcinoma 10.0 AFP CHGA
14 tubular adenocarcinoma 10.0 AFP CHGA
15 extraskeletal chondroma 10.0 PTH PTHLH
16 invasive malignant thymoma 10.0 PTH PTHLH
17 hypocalciuric hypercalcemia, familial, type iii 10.0 PTH PTHLH
18 clear cell adenoma 10.0 PTH PTHLH
19 oncogenic osteomalacia 10.0 PTH PTHLH
20 hypercalcemia, infantile, 1 10.0 PTH PTHLH
21 cloacogenic carcinoma 9.9 PTH PTHLH
22 large cell carcinoma 9.9 CHGA PTHLH
23 metaphyseal chondrodysplasia, jansen type 9.9 PTH PTHLH
24 parathyroid gland disease 9.9 PTH PTHLH
25 pseudohypoparathyroidism 9.9 PTH PTHLH
26 pseudohypoparathyroidism, type ib 9.9 PTH PTHLH
27 hypoparathyroidism 9.9 PTH PTHLH
28 mineral metabolism disease 9.9 PTH PTHLH
29 liver sarcoma 9.9 AFP CHGA PTHLH
30 endocrine gland cancer 9.8 AFP CHGA
31 adenocarcinoma 9.8
32 endocrine organ benign neoplasm 9.8 CHGA PTH
33 cell type benign neoplasm 9.8 CHGA PTH
34 multiple endocrine neoplasia, type i 9.8 CHGA PTH
35 parathyroid adenoma 9.7 CHGA PTH PTHLH
36 primary hyperparathyroidism 9.7 CHGA PTH PTHLH
37 hyperparathyroidism 9.7 CHGA PTH PTHLH
38 bone disease 9.7 PTH PTHLH

Graphical network of the top 20 diseases related to Sclerosing Hepatic Carcinoma:



Diseases related to Sclerosing Hepatic Carcinoma

Symptoms & Phenotypes for Sclerosing Hepatic Carcinoma

MGI Mouse Phenotypes related to Sclerosing Hepatic Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 8.92 AFP CHGA PTH PTHLH

Drugs & Therapeutics for Sclerosing Hepatic Carcinoma

Search Clinical Trials , NIH Clinical Center for Sclerosing Hepatic Carcinoma

Genetic Tests for Sclerosing Hepatic Carcinoma

Anatomical Context for Sclerosing Hepatic Carcinoma

MalaCards organs/tissues related to Sclerosing Hepatic Carcinoma:

41
Liver, Bone, Ovary

Publications for Sclerosing Hepatic Carcinoma

Articles related to Sclerosing Hepatic Carcinoma:

(show all 11)
# Title Authors Year
1
Hemodynamics of small sclerosing hepatocellular carcinoma without fibrous capsule: evaluation with single-level dynamic CT during hepatic arteriography. ( 17657527 )
2008
2
Sclerosing hepatic carcinoma: helical CT features. ( 17203330 )
2007
3
Sclerosing hepatocellular carcinoma: clinicopathologic features in seven patients from Taiwan and review of the literature. ( 16001661 )
2005
4
In situ demonstration of parathyroid hormone-related protein mRNA in sclerosing hepatic carcinoma. ( 10599313 )
1999
5
Sclerosing hepatic carcinoma in non-cirrhotic liver resembling metastatic adenocarcinoma. ( 9927164 )
1999
6
Immunohistochemical detection of parathyroid hormone-related protein in a rare variant of hepatic neoplasm (sclerosing hepatic carcinoma). ( 8698319 )
1996
7
Sclerosing hepatocellular carcinoma: radiologic findings. ( 8220034 )
1993
8
Sclerosing hepatocellular carcinoma with hypercalcemia--a case report. ( 1328759 )
1992
9
Computed tomography of sclerosing hepatocellular carcinoma. ( 1373669 )
1992
10
Sclerosing hepatic carcinoma: a report of a case treated with a transcatheter arterial embolization. ( 6522635 )
1984
11
Sclerosing hepatic carcinoma: relationship to hypercalcemia. ( 6294435 )
1981

Variations for Sclerosing Hepatic Carcinoma

Expression for Sclerosing Hepatic Carcinoma

Search GEO for disease gene expression data for Sclerosing Hepatic Carcinoma.

Pathways for Sclerosing Hepatic Carcinoma

Pathways related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.42 PTH PTHLH
2 11.18 PTH PTHLH
3 10.77 PTH PTHLH
4 10.21 PTH PTHLH

GO Terms for Sclerosing Hepatic Carcinoma

Cellular components related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 AFP CHGA PTH PTHLH
2 extracellular space GO:0005615 8.92 AFP CHGA PTH PTHLH

Biological processes related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.32 PTH PTHLH
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.26 PTH PTHLH
3 bone mineralization GO:0030282 9.16 PTH PTHLH
4 negative regulation of chondrocyte differentiation GO:0032331 8.96 PTH PTHLH
5 cAMP metabolic process GO:0046058 8.62 PTH PTHLH

Molecular functions related to Sclerosing Hepatic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 PTH PTHLH
2 peptide hormone receptor binding GO:0051428 8.62 PTH PTHLH

Sources for Sclerosing Hepatic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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