MCID: SCL011
MIFTS: 21

Sclerosing Keratitis

Categories: Eye diseases

Aliases & Classifications for Sclerosing Keratitis

MalaCards integrated aliases for Sclerosing Keratitis:

Name: Sclerosing Keratitis 12 15 73
Sclerokeratitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14444
ICD10 33 H16.33
ICD9CM 35 370.54
SNOMED-CT 68 27886001
UMLS 73 C0155090

Summaries for Sclerosing Keratitis

MalaCards based summary : Sclerosing Keratitis, also known as sclerokeratitis, is related to cataract and uveitis. An important gene associated with Sclerosing Keratitis is SRCIN1 (SRC Kinase Signaling Inhibitor 1). Affiliated tissues include eye, t cells and testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Sclerosing Keratitis

Diseases related to Sclerosing Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 cataract 10.1
2 uveitis 10.1
3 pyoderma 10.1
4 pyoderma gangrenosum 10.1
5 endophthalmitis 10.1
6 anterior uveitis 10.1
7 loiasis 10.0 MFF SRCIN1
8 deep keratitis 10.0 MFF SRCIN1
9 elephantiasis 10.0 MFF SRCIN1
10 3-methylglutaconic aciduria, type iii 9.9
11 keratoconus 9.9
12 keratopathy 9.9
13 hypopyon 9.9
14 tolosa-hunt syndrome 9.9
15 squamous cell carcinoma 9.9
16 iga glomerulonephritis 9.9
17 conjunctivitis 9.9
18 herpes zoster 9.9
19 mycobacterium abscessus 9.9
20 mycobacterium marinum 9.9
21 parasitic helminthiasis infectious disease 9.9 MFF SRCIN1
22 scleritis 9.9
23 punctate epithelial keratoconjunctivitis 9.8 B2M SRCIN1
24 urinary system disease 9.7 B2M PRTN3
25 anterior scleritis 9.3 B2M GLS2 MFF PRTN3 SRCIN1

Graphical network of the top 20 diseases related to Sclerosing Keratitis:



Diseases related to Sclerosing Keratitis

Symptoms & Phenotypes for Sclerosing Keratitis

GenomeRNAi Phenotypes related to Sclerosing Keratitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.17 PRTN3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.17 PRTN3
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.17 GLS2 PRTN3
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.17 PRTN3
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.17 GLS2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.17 GLS2

Drugs & Therapeutics for Sclerosing Keratitis

Search Clinical Trials , NIH Clinical Center for Sclerosing Keratitis

Genetic Tests for Sclerosing Keratitis

Anatomical Context for Sclerosing Keratitis

MalaCards organs/tissues related to Sclerosing Keratitis:

41
Eye, T Cells, Testes

Publications for Sclerosing Keratitis

Articles related to Sclerosing Keratitis:

(show all 48)
# Title Authors Year
1
Presumed Tuberculous Sclerokeratitis Presenting with Hypopyon. ( 30148654 )
2018
2
Surgical treatment of Metarhizium anisopliae sclerokeratitis and endophthalmitis. ( 28643721 )
2017
3
Clinical manifestations and outcome of tuberculous sclerokeratitis. ( 26701691 )
2016
4
Late-onset peripheral ulcerative sclerokeratitis associated with alkali chemical burn. ( 25542559 )
2015
5
Severe fungal sclerokeratitis caused by Metarhizium anisopliae: a case report and literature review. ( 25590990 )
2015
6
Histopathological examination of Acanthamoeba sclerokeratitis. ( 24548999 )
2014
7
Polymicrobial sclerokeratitis caused by Scedosporium apiospermum and Aspergillus cibarius. ( 24937168 )
2014
8
Acanthamoeba sclerokeratitis: epidemiology, clinical features, and treatment outcomes. ( 25097155 )
2014
9
Late-onset peripheral ulcerative sclerokeratitis associated with alkali chemical burn. ( 25194228 )
2014
10
Granulomatous inflammation in Acanthamoeba sclerokeratitis. ( 23552359 )
2013
11
Cotrimoxazole-resistant Nocardia sclerokeratitis: effective therapy with fourth-generation fluoroquinolones. ( 23217523 )
2012
12
Enucleation following treatment with intravenous pentamidine for Acanthamoeba sclerokeratitis. ( 20957062 )
2010
13
Acanthamoeba sclerokeratitis. ( 18843498 )
2009
14
A case of necrotizing sclerokeratitis and endophthalmitis caused by Beauveria bassiana. ( 19847617 )
2009
15
Postkeratoplasty atopic sclerokeratitis in keratoconus patients. ( 17884169 )
2008
16
Atypical fungal sclerokeratitis. ( 18362676 )
2008
17
Conservative management of Pseudomonal infectious sclerokeratitis. ( 18399802 )
2008
18
Listeria monocytogenes sclerokeratitis: a case report and literature review. ( 18724160 )
2008
19
Acute sclerokeratitis after cataract surgery: treatment with topical use of cyclosporine - a. ( 19478924 )
2008
20
Visual outcome and rehabilitation in a case of bilateral acanthamoeba sclerokeratitis. ( 17893557 )
2007
21
Keratectasia as a presentation of surgically induced necrotizing sclerokeratitis (SINS). ( 17993831 )
2007
22
The management of severe sclerokeratitis following corneal transplantation surgery. ( 16782954 )
2006
23
Scedosporium prolificans sclerokeratitis 10 years after pterygium excision with adjunctive mitomycin C. ( 16033367 )
2005
24
Acanthamoeba sclerokeratitis: treatment with systemic immunosuppression. ( 12045063 )
2002
25
Nocardia asteroides sclerokeratitis in a contact lens wearer. ( 12054371 )
2002
26
Use of cyclosporin in the treatment of steroid resistant post-keratoplasty atopic sclerokeratitis. ( 11133720 )
2001
27
Sclerokeratitis: an unusual presentation of squamous cell carcinoma of the conjunctiva. ( 11237910 )
2001
28
Severe sclerokeratitis due to Pseudomonas aeruginosa in noncontact-lens wearers. ( 10755091 )
2000
29
Severe Acanthamoeba sclerokeratitis in a non-contact lens wearer. ( 10406160 )
1999
30
Pyoderma gangrenosum and necrotising sclerokeratitis. ( 9603395 )
1998
31
Necrotizing sclerokeratitis following uncomplicated cataract surgery. ( 9686862 )
1998
32
A peculiar case of necrotizing sclerokeratitis with Pseudomonas infection. ( 8936773 )
1995
33
Infiltration of CD4+ T cells into cornea during development of Onchocerca volvulus-induced experimental sclerosing keratitis in mice. ( 7994762 )
1994
34
Scedosporium prolificans sclerokeratitis. ( 7818880 )
1994
35
Acanthamoeba sclerokeratitis. ( 8154529 )
1994
36
ANCA associated with scleritis and sclerosing keratitis. ( 8258251 )
1993
37
Immune-mediated Onchocerca volvulus sclerosing keratitis in the mouse. ( 7691631 )
1993
38
Wegener's granulomatosis presenting with sclerokeratitis diagnosed by antineutrophil cytoplasmic autoantibodies (ANCA). ( 8484170 )
1993
39
Postoperative necrotizing sclerokeratitis. ( 1425131 )
1992
40
Surgically induced necrotising sclerokeratitis (SINS)--precipitating factors and response to treatment. ( 1739684 )
1992
41
cANCA test and the detection of Wegener's disease in sclerokeratitis and uveitis. ( 2384015 )
1990
42
Fluorescein angiography in the differential diagnosis of sclerokeratitis. ( 3828265 )
1987
43
Acanthamoeba sclerokeratitis. Determining diagnostic criteria. ( 3753282 )
1986
44
Peculiar inflammation of external ear associated with conjunctivitis and sclerokeratitis. ( 13217554 )
1955
45
A CASE OF SCLEROSING KERATITIS PROFUNDA. ( 18169380 )
1936
46
A Case of Tuberculous Sclerokeratitis. ( 16692968 )
1933
47
Case of Sclerosing Keratitis of Right Eye. ( 19982512 )
1922
48
The Experimental Production of Sclerokeratitis and Chronic Intraocular Tuberculosis. ( 16692293 )
1913

Variations for Sclerosing Keratitis

Expression for Sclerosing Keratitis

Search GEO for disease gene expression data for Sclerosing Keratitis.

Pathways for Sclerosing Keratitis

GO Terms for Sclerosing Keratitis

Sources for Sclerosing Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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