MCID: SCL004
MIFTS: 26

Sclerosing Liposarcoma

Categories: Cancer diseases

Aliases & Classifications for Sclerosing Liposarcoma

MalaCards integrated aliases for Sclerosing Liposarcoma:

Name: Sclerosing Liposarcoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5704
NCIt 50 C6507
SNOMED-CT 68 28655007 404068003
UMLS 73 C0334469

Summaries for Sclerosing Liposarcoma

MalaCards based summary : Sclerosing Liposarcoma is related to liposarcoma and hemangiopericytoma, malignant. An important gene associated with Sclerosing Liposarcoma is EPHB2 (EPH Receptor B2), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Sclerosing Liposarcoma

Diseases related to Sclerosing Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 liposarcoma 28.0 CD34 FUS MB MDM2 TP53
2 hemangiopericytoma, malignant 10.5 MDM2 STAT6
3 mesenchymoma 10.4 MB MDM2
4 extraosseous osteosarcoma 10.4 CD34 MDM2
5 ischemic fasciitis 10.4 CD34 MDM2
6 lipomatosis, multiple 10.4 FUS MDM2
7 proliferative fasciitis 10.4 MB STAT6
8 ring chromosome 7 10.3 MDM2 TP53
9 zika virus infection 10.3 MDM2 TP53
10 actinic cheilitis 10.3 MDM2 TP53
11 lip cancer 10.3 MDM2 TP53
12 dedifferentiated liposarcoma 10.3 MDM2 TP53
13 gliomatosis cerebri 10.3 MDM2 TP53
14 soft tissue sarcoma 10.3 MDM2 TP53
15 small cell sarcoma 10.3 MDM2 TP53
16 embryonal sarcoma 10.2 MDM2 TP53
17 endocervical adenocarcinoma 10.2 PAX8 TP53
18 nephrogenic adenofibroma 10.2 CD34 PAX8
19 uterine sarcoma 10.2 MB MDM2
20 angiomyoma 10.2 CD34 MB
21 cheilitis 10.2 MDM2 TP53
22 cellular neurofibroma 10.1 CD34 TP53
23 adult medulloblastoma 10.1 MDM2 TP53
24 spindle cell synovial sarcoma 10.1 CD34 MB
25 cardiovascular organ benign neoplasm 10.1 CD34 MB
26 adenosarcoma 10.1 MB TP53
27 pleuropulmonary blastoma 10.1 MB TP53
28 breast benign neoplasm 10.1 CD34 TP53
29 thoracic benign neoplasm 10.1 CD34 TP53
30 benign perivascular tumor 10.1 CD34 MB
31 heart sarcoma 10.1 CREB3L2 MDM2
32 mixed cell type cancer 10.0 MB TP53
33 giant cell glioblastoma 10.0 MDM2 TP53
34 liver angiosarcoma 10.0 CD34 TP53
35 glomangioma 10.0 CD34 MB
36 ovarian cancer 1 10.0 PAX8 TP53
37 medullomyoblastoma 10.0 MB TP53
38 myxofibrosarcoma 10.0 CREB3L2 FUS
39 malignant ovarian surface epithelial-stromal neoplasm 9.9 PAX8 TP53
40 fibrosarcoma of bone 9.9 CREB3L2 MDM2
41 clear cell ependymoma 9.9 CD34 TP53
42 ovary epithelial cancer 9.9 PAX8 TP53
43 deep angioma 9.9 CD34 CREB3L2
44 retinal cancer 9.9 MDM2 TP53
45 brain cancer 9.9 EPHB2 MDM2 TP53
46 intramuscular hemangioma 9.9 CD34 CREB3L2
47 synovium cancer 9.9 CD34 CREB3L2
48 myxoid liposarcoma 9.8 FUS MDM2 TP53
49 sensory system cancer 9.8 MDM2 TP53
50 skin sarcoma 9.8 CD34 CREB3L2

Graphical network of the top 20 diseases related to Sclerosing Liposarcoma:



Diseases related to Sclerosing Liposarcoma

Symptoms & Phenotypes for Sclerosing Liposarcoma

GenomeRNAi Phenotypes related to Sclerosing Liposarcoma according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.7 FUS
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.7 TP53
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.7 TP53
4 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.7 TP53
5 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.7 FUS
6 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.7 TP53
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.7 STAT6
8 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.7 STAT6
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.7 TP53
10 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.7 TP53 FUS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-201 9.7 STAT6
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.7 FUS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.7 FUS
14 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.7 TP53
15 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.7 TP53 FUS STAT6
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.7 STAT6
17 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.7 STAT6
18 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.7 FUS
19 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.7 FUS
20 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.7 STAT6
21 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.7 FUS

MGI Mouse Phenotypes related to Sclerosing Liposarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 TP53 CD34 EPHB2 MB MDM2 PAX8
2 craniofacial MP:0005382 9.55 TP53 CREB3L2 EPHB2 MDM2 PAX8
3 growth/size/body region MP:0005378 9.5 STAT6 TP53 CREB3L2 EPHB2 MB MDM2
4 renal/urinary system MP:0005367 9.02 TP53 EPHB2 MDM2 PAX8 STAT6

Drugs & Therapeutics for Sclerosing Liposarcoma

Search Clinical Trials , NIH Clinical Center for Sclerosing Liposarcoma

Genetic Tests for Sclerosing Liposarcoma

Anatomical Context for Sclerosing Liposarcoma

Publications for Sclerosing Liposarcoma

Articles related to Sclerosing Liposarcoma:

# Title Authors Year
1
Sclerosing liposarcoma of the anterior mediastinum: An unusual case. ( 26960640 )
2016
2
Sclerosing liposarcoma of epididymis: Role of chemical shift magnetic resonance imaging. ( 27857462 )
2016
3
Cytologic features of well-differentiated sclerosing liposarcoma in aspirated samples. ( 3201879 )
1988
4
Ultrastructural and histochemical identification of sclerosing liposarcoma. ( 7216183 )
1981

Variations for Sclerosing Liposarcoma

Expression for Sclerosing Liposarcoma

Search GEO for disease gene expression data for Sclerosing Liposarcoma.

Pathways for Sclerosing Liposarcoma

GO Terms for Sclerosing Liposarcoma

Biological processes related to Sclerosing Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.62 CREB3L2 PAX8 STAT6 TP53
2 response to antibiotic GO:0046677 9.43 MDM2 TP53
3 ventricular septum development GO:0003281 9.4 MDM2 PAX8
4 cellular response to gamma radiation GO:0071480 9.37 MDM2 TP53
5 positive regulation of protein export from nucleus GO:0046827 9.26 MDM2 TP53
6 positive regulation of gene expression GO:0010628 9.26 CD34 EPHB2 MDM2 TP53
7 urogenital system development GO:0001655 9.16 EPHB2 PAX8
8 cellular response to actinomycin D GO:0072717 8.62 MDM2 TP53

Molecular functions related to Sclerosing Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 9.43 CREB3L2 PAX8 TP53
2 disordered domain specific binding GO:0097718 9.16 MDM2 TP53
3 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0001228 9.13 CREB3L2 STAT6 TP53
4 identical protein binding GO:0042802 9.02 EPHB2 FUS MDM2 STAT6 TP53

Sources for Sclerosing Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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