MCID: SCL004
MIFTS: 30

Sclerosing Liposarcoma

Categories: Cancer diseases

Aliases & Classifications for Sclerosing Liposarcoma

MalaCards integrated aliases for Sclerosing Liposarcoma:

Name: Sclerosing Liposarcoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5704
NCIt 50 C6507
SNOMED-CT 68 28655007
UMLS 73 C0334469

Summaries for Sclerosing Liposarcoma

MalaCards based summary : Sclerosing Liposarcoma is related to liposarcoma and cellular myxoid liposarcoma. An important gene associated with Sclerosing Liposarcoma is EPHB2 (EPH Receptor B2), and among its related pathways/superpathways are Human cytomegalovirus infection and Endometrial cancer. Affiliated tissues include skin, brain and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Sclerosing Liposarcoma

Diseases related to Sclerosing Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 liposarcoma 29.7 CD34 FUS MB MDM2 TP53
2 cellular myxoid liposarcoma 10.2 FUS MDM2
3 atypical lipomatous tumor 10.2 FUS MDM2
4 mesenchymoma 10.1 MB MDM2
5 hemangiopericytoma, malignant 10.1 MDM2 STAT6
6 ischemic fasciitis 10.1 CD34 MDM2
7 proliferative fasciitis 10.1 MB STAT6
8 lipomatosis, multiple 10.1 FUS MDM2
9 ring chromosome 7 10.1 MDM2 TP53
10 zika virus infection 10.1 MDM2 TP53
11 actinic cheilitis 10.1 MDM2 TP53
12 cheilitis 10.1 MDM2 TP53
13 lip cancer 10.1 MDM2 TP53
14 gliomatosis cerebri 10.1 MDM2 TP53
15 soft tissue sarcoma 10.1 MDM2 TP53
16 small cell sarcoma 10.1 MDM2 TP53
17 verrucous carcinoma 10.1 MDM2 TP53
18 embryonal sarcoma 10.1 MDM2 TP53
19 endocervical adenocarcinoma 10.1 PAX8 TP53
20 nephrogenic adenofibroma 10.1 CD34 PAX8
21 cardia cancer 10.1 MDM2 TP53
22 adult fibrosarcoma 10.1 CD34 MB
23 angiomyoma 10.1 CD34 MB
24 uterine sarcoma 10.1 MB MDM2
25 sarcomatoid squamous cell skin carcinoma 10.0 CD34 MB
26 cellular neurofibroma 10.0 CD34 TP53
27 fibroepithelial basal cell carcinoma 10.0 CD34 TP53
28 adult medulloblastoma 10.0 MDM2 TP53
29 spindle cell synovial sarcoma 10.0 CD34 MB
30 rhabdoid cancer 10.0 MB TP53
31 adenosarcoma 10.0 MB TP53
32 pleuropulmonary blastoma 10.0 MB TP53
33 heart sarcoma 10.0 CREB3L2 MDM2
34 breast benign neoplasm 10.0 CD34 TP53
35 thoracic benign neoplasm 10.0 CD34 TP53
36 giant cell glioblastoma 10.0 MDM2 TP53
37 mixed cell type cancer 10.0 MB TP53
38 retinal cancer 10.0 MDM2 TP53
39 liver angiosarcoma 10.0 CD34 TP53
40 myxofibrosarcoma 10.0 CREB3L2 FUS
41 medullomyoblastoma 10.0 MB TP53
42 ovarian cancer 1 10.0 PAX8 TP53
43 fibrosarcoma of bone 10.0 CREB3L2 MDM2
44 deep angioma 10.0 CD34 CREB3L2
45 nervous system benign neoplasm 10.0 CD34 TP53
46 intramuscular hemangioma 10.0 CD34 CREB3L2
47 malignant ovarian surface epithelial-stromal neoplasm 9.9 PAX8 TP53
48 pseudosarcomatous fibromatosis 9.9 CD34 CREB3L2
49 myxoid liposarcoma 9.9 FUS MDM2 TP53
50 cardiovascular organ benign neoplasm 9.9 CD34 MB STAT6

Graphical network of the top 20 diseases related to Sclerosing Liposarcoma:



Diseases related to Sclerosing Liposarcoma

Symptoms & Phenotypes for Sclerosing Liposarcoma

GenomeRNAi Phenotypes related to Sclerosing Liposarcoma according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.7 FUS
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.7 TP53
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.7 TP53
4 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.7 TP53
5 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.7 FUS
6 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.7 TP53
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.7 STAT6
8 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.7 STAT6
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.7 TP53
10 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.7 FUS TP53
11 Increased shRNA abundance (Z-score > 2) GR00366-A-201 9.7 STAT6
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.7 FUS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.7 FUS
14 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.7 TP53
15 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.7 FUS STAT6 TP53
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.7 STAT6
17 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.7 STAT6
18 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.7 FUS
19 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.7 FUS
20 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.7 STAT6
21 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.7 FUS

MGI Mouse Phenotypes related to Sclerosing Liposarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 CD34 EPHB2 MB MDM2 PAX8 STAT6
2 craniofacial MP:0005382 9.55 CREB3L2 EPHB2 MDM2 PAX8 TP53
3 growth/size/body region MP:0005378 9.5 CREB3L2 EPHB2 MB MDM2 PAX8 STAT6
4 renal/urinary system MP:0005367 9.02 EPHB2 MDM2 PAX8 STAT6 TP53

Drugs & Therapeutics for Sclerosing Liposarcoma

Search Clinical Trials , NIH Clinical Center for Sclerosing Liposarcoma

Genetic Tests for Sclerosing Liposarcoma

Anatomical Context for Sclerosing Liposarcoma

MalaCards organs/tissues related to Sclerosing Liposarcoma:

41
Skin, Brain, Liver, Bone, Heart, Thyroid, Thymus

Publications for Sclerosing Liposarcoma

Articles related to Sclerosing Liposarcoma:

# Title Authors Year
1
Sclerosing liposarcoma of the anterior mediastinum: An unusual case. ( 26960640 )
2016
2
Sclerosing liposarcoma of epididymis: Role of chemical shift magnetic resonance imaging. ( 27857462 )
2016
3
Cytologic features of well-differentiated sclerosing liposarcoma in aspirated samples. ( 3201879 )
1988
4
Ultrastructural and histochemical identification of sclerosing liposarcoma. ( 7216183 )
1981

Variations for Sclerosing Liposarcoma

Expression for Sclerosing Liposarcoma

Search GEO for disease gene expression data for Sclerosing Liposarcoma.

Pathways for Sclerosing Liposarcoma

Pathways related to Sclerosing Liposarcoma according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 CREB3L2 MDM2 STAT6 TP53
2
Show member pathways
12.2 CREB3L2 MDM2 PAX8 TP53
3
Show member pathways
12.04 MDM2 STAT6 TP53
4 11.98 MDM2 PAX8 STAT6 TP53
5 11.88 CREB3L2 MDM2 TP53
6
Show member pathways
11.86 CREB3L2 MDM2 TP53
7 11.7 CREB3L2 MDM2 TP53
8 11.2 MDM2 TP53
9 11.19 FUS MDM2 PAX8 TP53
10 11.17 MDM2 TP53
11 10.96 MDM2 TP53
12 10.92 MDM2 TP53
13 10.66 MDM2 TP53
14
Show member pathways
10.6 MDM2 TP53

GO Terms for Sclerosing Liposarcoma

Biological processes related to Sclerosing Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.85 CREB3L2 FUS PAX8 STAT6 TP53
2 transcription by RNA polymerase II GO:0006366 9.62 CREB3L2 PAX8 STAT6 TP53
3 response to antibiotic GO:0046677 9.43 MDM2 TP53
4 ventricular septum development GO:0003281 9.4 MDM2 PAX8
5 cellular response to gamma radiation GO:0071480 9.37 MDM2 TP53
6 positive regulation of protein export from nucleus GO:0046827 9.26 MDM2 TP53
7 urogenital system development GO:0001655 9.16 EPHB2 PAX8
8 positive regulation of gene expression GO:0010628 9.02 CD34 CREB3L2 EPHB2 MDM2 TP53
9 cellular response to actinomycin D GO:0072717 8.96 MDM2 TP53

Molecular functions related to Sclerosing Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 9.43 CREB3L2 PAX8 TP53
2 identical protein binding GO:0042802 9.35 EPHB2 FUS MDM2 STAT6 TP53
3 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.33 CREB3L2 STAT6 TP53
4 disordered domain specific binding GO:0097718 9.32 MDM2 TP53
5 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 8.92 CREB3L2 PAX8 STAT6 TP53

Sources for Sclerosing Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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