MCID: SCL004
MIFTS: 31

Sclerosing Liposarcoma

Categories: Cancer diseases

Aliases & Classifications for Sclerosing Liposarcoma

MalaCards integrated aliases for Sclerosing Liposarcoma:

Name: Sclerosing Liposarcoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5704
NCIt 51 C6507
SNOMED-CT 69 28655007
UMLS 74 C0334469

Summaries for Sclerosing Liposarcoma

MalaCards based summary : Sclerosing Liposarcoma is related to liposarcoma and cellular myxoid liposarcoma. An important gene associated with Sclerosing Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Human cytomegalovirus infection and Endometrial cancer. Affiliated tissues include skin, cervix and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Sclerosing Liposarcoma

Diseases related to Sclerosing Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 liposarcoma 28.7 CD34 CDKN2A FUS MB MDM2 TP53
2 cellular myxoid liposarcoma 10.3 FUS MDM2
3 myxofibrosarcoma 10.3 FUS MDM2
4 chondroid lipoma 10.3 FUS MDM2
5 mesenchymoma 10.3 MB MDM2
6 conventional fibrosarcoma 10.3 CD34 MDM2
7 hemangiopericytoma, malignant 10.3 MDM2 STAT6
8 spindle cell liposarcoma 10.2 CD34 MDM2
9 infiltrating lipoma 10.2 CD34 MDM2
10 lipomatosis, multiple 10.2 FUS MDM2
11 proliferative fasciitis 10.2 MB STAT6
12 ring chromosome 7 10.2 MDM2 TP53
13 zika virus infection 10.2 MDM2 TP53
14 actinic cheilitis 10.2 MDM2 TP53
15 cheilitis 10.2 MDM2 TP53
16 lip cancer 10.2 MDM2 TP53
17 sapho syndrome 10.2 MDM2 TP53
18 gliomatosis cerebri 10.2 MDM2 TP53
19 soft tissue sarcoma 10.2 MDM2 TP53
20 small cell sarcoma 10.2 MDM2 TP53
21 sarcomatoid renal cell carcinoma 10.2 PAX8 TP53
22 embryonal sarcoma 10.2 MDM2 TP53
23 cardia cancer 10.2 MDM2 TP53
24 uterine sarcoma 10.1 MB MDM2
25 nephrogenic adenofibroma 10.1 CD34 PAX8
26 adult fibrosarcoma 10.1 CD34 MB
27 angiomyoma 10.1 CD34 MB
28 adult medulloblastoma 10.1 MDM2 TP53
29 sarcomatoid squamous cell skin carcinoma 10.1 CD34 MB
30 cellular neurofibroma 10.1 CD34 TP53
31 infiltrating angiolipoma 10.1 CDKN2A MDM2
32 fibroepithelial basal cell carcinoma 10.1 CD34 TP53
33 spindle cell synovial sarcoma 10.1 CD34 MB
34 periosteal chondrosarcoma 10.1 CDKN2A MDM2
35 rhabdoid cancer 10.1 MB TP53
36 pleomorphic liposarcoma 10.1 CDKN2A MDM2
37 well-differentiated liposarcoma 10.1 CDKN2A MDM2
38 adenosarcoma 10.1 MB TP53
39 pleuropulmonary blastoma 10.1 MB TP53
40 endocervical carcinoma 10.1 CDKN2A PAX8
41 breast benign neoplasm 10.1 CD34 TP53
42 thoracic benign neoplasm 10.1 CD34 TP53
43 giant cell glioblastoma 10.0 MDM2 TP53
44 mixed cell type cancer 10.0 MB TP53
45 liver angiosarcoma 10.0 CD34 TP53
46 medullomyoblastoma 10.0 MB TP53
47 cervical adenosquamous carcinoma 10.0 CDKN2A PAX8
48 adenocarcinoma in situ 10.0 CDKN2A PAX8
49 fibrosarcoma of bone 10.0 CDKN2A MDM2
50 vulvar dystrophy 10.0 CD34 CDKN2A

Graphical network of the top 20 diseases related to Sclerosing Liposarcoma:



Diseases related to Sclerosing Liposarcoma

Symptoms & Phenotypes for Sclerosing Liposarcoma

GenomeRNAi Phenotypes related to Sclerosing Liposarcoma according to GeneCards Suite gene sharing:

27 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.7 FUS
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.7 TP53
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.7 TP53
4 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.7 TP53
5 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.7 FUS
6 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.7 TP53
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.7 STAT6
8 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.7 STAT6
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.7 TP53
10 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.7 FUS TP53
11 Increased shRNA abundance (Z-score > 2) GR00366-A-201 9.7 STAT6
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.7 FUS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.7 FUS
14 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.7 TP53
15 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.7 FUS STAT6 TP53
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.7 STAT6
17 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.7 STAT6
18 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.7 FUS
19 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.7 FUS
20 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.7 STAT6
21 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.7 FUS

MGI Mouse Phenotypes related to Sclerosing Liposarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 CD34 CDKN2A EPHB2 MB MDM2 PAX8
2 endocrine/exocrine gland MP:0005379 9.8 CDKN2A EPHB2 MDM2 PAX8 STAT6 TP53
3 growth/size/body region MP:0005378 9.8 CDKN2A EPHB2 MB MDM2 PAX8 STAT6
4 neoplasm MP:0002006 9.55 CD34 CDKN2A MDM2 STAT6 TP53
5 renal/urinary system MP:0005367 9.35 EPHB2 MDM2 PAX8 STAT6 TP53
6 reproductive system MP:0005389 9.1 CDKN2A EPHB2 MDM2 PAX8 STAT6 TP53

Drugs & Therapeutics for Sclerosing Liposarcoma

Search Clinical Trials , NIH Clinical Center for Sclerosing Liposarcoma

Genetic Tests for Sclerosing Liposarcoma

Anatomical Context for Sclerosing Liposarcoma

MalaCards organs/tissues related to Sclerosing Liposarcoma:

42
Skin, Cervix, Bone, Brain, Kidney, Liver, Thyroid

Publications for Sclerosing Liposarcoma

Articles related to Sclerosing Liposarcoma:

# Title Authors Year
1
Sclerosing liposarcoma of the anterior mediastinum: An unusual case. ( 26960640 )
2016
2
Sclerosing liposarcoma of epididymis: Role of chemical shift magnetic resonance imaging. ( 27857462 )
2016
3
Cytologic features of well-differentiated sclerosing liposarcoma in aspirated samples. ( 3201879 )
1988
4
Ultrastructural and histochemical identification of sclerosing liposarcoma. ( 7216183 )
1981

Variations for Sclerosing Liposarcoma

Expression for Sclerosing Liposarcoma

Search GEO for disease gene expression data for Sclerosing Liposarcoma.

Pathways for Sclerosing Liposarcoma

Pathways related to Sclerosing Liposarcoma according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 CDKN2A MDM2 STAT6 TP53
2
Show member pathways
12.6 CDKN2A MDM2 PAX8 TP53
3 12.44 CDKN2A MDM2 PAX8 STAT6 TP53
4
Show member pathways
12.16 MDM2 STAT6 TP53
5
Show member pathways
12.14 CDKN2A MDM2 TP53
6 12.12 CDKN2A MDM2 TP53
7 12.05 CDKN2A MDM2 TP53
8 11.9 CDKN2A MDM2 TP53
9 11.83 FUS MDM2 PAX8 TP53
10 11.81 CDKN2A MDM2 TP53
11 11.75 CDKN2A MDM2 TP53
12 11.72 CDKN2A MDM2 TP53
13 11.68 CDKN2A MDM2 TP53
14 11.5 CDKN2A MDM2 TP53
15 11.47 CDKN2A MDM2 TP53
16 11.44 CDKN2A MDM2 TP53
17
Show member pathways
11.44 CDKN2A MDM2 TP53
18 11.28 CDKN2A MDM2 TP53
19 11.25 MDM2 TP53
20 11.07 MDM2 TP53
21 10.84 CDKN2A MDM2 TP53
22 10.47 CDKN2A MDM2 TP53
23
Show member pathways
10.14 CDKN2A MDM2 TP53

GO Terms for Sclerosing Liposarcoma

Biological processes related to Sclerosing Liposarcoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein destabilization GO:0031648 9.49 CDKN2A MDM2
2 protein sumoylation GO:0016925 9.48 CDKN2A MDM2
3 response to antibiotic GO:0046677 9.46 MDM2 TP53
4 ventricular septum development GO:0003281 9.43 MDM2 PAX8
5 cellular response to gamma radiation GO:0071480 9.4 MDM2 TP53
6 positive regulation of protein export from nucleus GO:0046827 9.37 MDM2 TP53
7 urogenital system development GO:0001655 9.32 EPHB2 PAX8
8 replicative senescence GO:0090399 9.26 CDKN2A TP53
9 amyloid fibril formation GO:1990000 9.16 CDKN2A MDM2
10 positive regulation of gene expression GO:0010628 9.02 CD34 CDKN2A EPHB2 MDM2 TP53
11 cellular response to actinomycin D GO:0072717 8.96 MDM2 TP53

Molecular functions related to Sclerosing Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 EPHB2 FUS MDM2 STAT6 TP53
2 SUMO transferase activity GO:0019789 9.16 CDKN2A MDM2
3 disordered domain specific binding GO:0097718 8.8 CDKN2A MDM2 TP53

Sources for Sclerosing Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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