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MCID: SCL057
MIFTS: 40

Scoliosis, Isolated 1

Categories: Rare diseases
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Scoliosis, Isolated 1

About this section

MalaCards integrated aliases for Scoliosis, Isolated 1:

Name: Scoliosis, Isolated 1 57
Adolescent Idiopathic Scoliosis 57 53 25
Scoliosis, Isolated, Susceptibility to, 1 57 6
Idiopathic Adolescent Scoliosis 76 53
Scoliosis, Idiopathic 1 57 13
Ais 57 25
Adolescent Isolated Scoliosis; Ais 57
Late Onset Idiopathic Scoliosis 25
Adolescent Isolated Scoliosis 57
Is1 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant vs. multifactorial


Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 57 181800
MedGen 42 C2700406
SNOMED-CT via HPO 69 111266001 64217002
Sources

Summaries for Scoliosis, Isolated 1

About this section
NIH Rare Diseases : 53 Adolescent idiopathic scoliosis is an abnormal curvature of the spine that appears in late childhood or adolescence. Instead of growing straight, the spine develops a side-to-side curvature, usually in an elongated "s" or "C" shape, and the bones of the spine become slightly twisted or rotated. In many cases, the abnormal spinal curve is stable; however, in some children, the curve becomes more severe over time (progressive). For unknown reasons, severe and progressive curves occur more frequently in girls than in boys. The cause of adolescent idiopathic scoliosis is unknown. It is likely that there are both genetic and environmental factors involved. Treatment may include observation, bracing and/or surgery.

MalaCards based summary : Scoliosis, Isolated 1, also known as adolescent idiopathic scoliosis, is related to androgen insensitivity syndrome and amelogenesis imperfecta. An important gene associated with Scoliosis, Isolated 1 is MAPK7 (Mitogen-Activated Protein Kinase 7). The drugs Thrombin and Parecoxib have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and liver, and related phenotype is scoliosis.

Genetics Home Reference : 25 Adolescent idiopathic scoliosis is an abnormal curvature of the spine that appears in late childhood or adolescence. Instead of growing straight, the spine develops a side-to-side curvature, usually in an elongated "S" or "C" shape; the bones of the spine are also slightly twisted or rotated.

OMIM : 57 Idiopathic scoliosis is a structurally fixed lateral curvature of the spine with a rotatory component. There is at least a 10 degree curvature as demonstrated by upright spine roentgenograms by the Cobb method (Weinstein, 1994). Scoliosis may occur secondary to other hereditary disorders including Marfan syndrome (154700), dysautonomia (223900), neurofibromatosis (see 162200), Friedreich ataxia (see 229300), and muscular dystrophies. (181800)

Wikipedia : 76 Scoliosis is a medical condition in which a person\'s spine has a sideways curve. The curve is usually... more...

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Related Diseases for Scoliosis, Isolated 1

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Diseases in the Scoliosis, Isolated 1 family:

Scoliosis, Isolated 2 Scoliosis, Isolated 3
Scoliosis, Isolated 4 Scoliosis, Isolated 5

Diseases related to Scoliosis, Isolated 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 androgen insensitivity syndrome 11.9
2 amelogenesis imperfecta 11.8
3 autoimmune inner ear disease 11.8
4 aland island eye disease 11.7
5 hereditary amyloidosis 11.2
6 aortic valve insufficiency 11.1
7 childhood-onset cerebral x-linked adrenoleukodystrophy 11.1
8 scoliosis 11.1
9 idiopathic scoliosis 11.1
10 pediatric arterial ischemic stroke 11.0
11 amelogenesis imperfecta, type ib 11.0
12 scoliosis, isolated 3 10.9
13 scoliosis, isolated 4 10.9
14 scoliosis, isolated 5 10.9
15 salt and pepper developmental regression syndrome 10.9
16 jalili syndrome 10.8
17 amelogenesis imperfecta, type ie 10.8
18 amelogenesis imperfecta, type ij 10.8
19 alzheimer disease 10.7
20 neuronitis 10.3
21 cerebritis 10.2
22 amyloidosis 10.2
23 aging 10.2
24 adenocarcinoma 10.1
25 dementia 10.1
26 adenocarcinoma in situ 10.1
27 cerebral amyloid angiopathy, cst3-related 10.1
28 arteries, anomalies of 10.1

Graphical network of the top 20 diseases related to Scoliosis, Isolated 1:



Diseases related to Scoliosis, Isolated 1
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Symptoms & Phenotypes for Scoliosis, Isolated 1

About this section

Symptoms via clinical synopsis from OMIM:

57
Spine:
scoliosis


Clinical features from OMIM:

181800

Human phenotypes related to Scoliosis, Isolated 1:

32
# Description HPO Frequency HPO Source Accession
1 scoliosis 32 HP:0002650
Sources

Drugs & Therapeutics for Scoliosis, Isolated 1

About this section

Drugs for Scoliosis, Isolated 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 700)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 4
2 Parecoxib Approved Phase 4 198470-84-7
3
Sufentanil Approved, Investigational Phase 4,Not Applicable 56030-54-7 41693
4
Liraglutide Approved Phase 4,Phase 2 204656-20-2 44147092
5
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
6
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
8
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
9
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 2078-54-8 4943
10
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2 216974-75-3
11
Budesonide Approved Phase 4 51333-22-3 63006 5281004
12
Ipratropium Approved Phase 4 22254-24-6, 60205-81-4 43232
13
Terbutaline Approved Phase 4 23031-25-6 5403
14
Chromium Approved Phase 4,Not Applicable 7440-47-3 27668
15
Everolimus Approved Phase 4,Phase 3,Phase 2,Not Applicable 159351-69-6 6442177
16
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 22916-47-8 4189
17
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53123-88-9 5284616 6436030 46835353
18
Etomidate Approved Phase 4 33125-97-2 36339 667484
19
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
20
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
21
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 128794-94-5 5281078
22
Mycophenolic acid Approved Phase 4,Phase 2,Phase 1,Not Applicable 24280-93-1 446541
23
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 104987-11-3 445643 439492
24
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
25
Levobupivacaine Approved, Investigational Phase 4,Not Applicable 27262-47-1 92253
26
Morphine Approved, Investigational Phase 4,Not Applicable 57-27-2 5288826
27
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2 93-14-1 3516
28
Loperamide Approved Phase 4 53179-11-6 3955
29
Methadone Approved Phase 4 76-99-3 4095
30
Opium Approved, Illicit Phase 4 8008-60-4
31
Phenobarbital Approved, Investigational Phase 4 50-06-6 4763
32
Chlorthalidone Approved Phase 4 77-36-1 2732
33
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
34
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2 198153-51-4 5360545
35
Ribavirin Approved Phase 4,Phase 2 36791-04-5 37542
36
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
37
Ofloxacin Approved Phase 4 82419-36-1 4583
38
Risperidone Approved, Investigational Phase 4,Phase 3 106266-06-2 5073
39
Meperidine Approved Phase 4 57-42-1 4058
40
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
41
Adefovir Dipivoxil Approved, Investigational Phase 4,Phase 3 142340-99-6 60871
42
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
43
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
44
Valganciclovir Approved, Investigational Phase 4 175865-60-8 64147
45
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
46
Pioglitazone Approved, Investigational Phase 4,Phase 3 111025-46-8 4829
47
Methotrexate Approved Phase 4,Phase 3 1959-05-2, 59-05-2 126941
48
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
49
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
50
Edetic Acid Approved, Vet_approved Phase 4,Phase 1,Phase 2 60-00-4, 62-33-9 6049

Interventional clinical trials:

(show top 50) (show all 724)
# Name Status NCT ID Phase Drugs
1 Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery Unknown status NCT01451788 Phase 4
2 Role of Parecoxib Sodium for Postoperative Pain Management in Open Hepatectomy Unknown status NCT02204878 Phase 4 Parecoxib Sodium
3 GLP-1 Analogue Treatment in Uncontrolled Type 1 Diabetic Patients Unknown status NCT01592279 Phase 4 liraglutide;Insulin injections
4 Sequential Use of Propofol/Midazolam and Dexmedetomidine for Sedation in Mechenical Ventialtion Patients in ICU. Unknown status NCT02122055 Phase 4 Fentanyl;Propofol;Midazolam;Dexmedetomidine
5 Coronary Angioplasty in Octogenarians With Emergent Coronary Syndromes Unknown status NCT02126202 Phase 4
6 Use of Bevacizumab to Modulate the Outcomes of Trabeculectomy Surgery Unknown status NCT01229202 Phase 4 Bevacizumab
7 Efficacy of Nebulized Pulmicort Respules in Primary Lung Cancer Patients With COPD Unknown status NCT02504801 Phase 4 Budesonide
8 Comparison of Strut Coverage With OPTIMAX Versus SYNERGY Stents Unknown status NCT02464397 Phase 4
9 The Feasibility of Different Doses of Etomidate Admixed With Propofol in Induced Abortion: A Randomized, Double Blind Controlled Trial Unknown status NCT02208596 Phase 4 pentazocine;propofol;Etomidate
10 Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
11 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
12 Treatment of Neonatal Abstinence Syndrome Completed NCT01723722 Phase 4 Methadone;Diluted Deodorized Tincture of Opium
13 Tolerance to Target Doses of Thiazides in Actual Practice: A Feasibility Study Completed NCT01235377 Phase 4
14 A Study to Assess Immune Response in Pediatric Kidney Transplant Recipients Treated With Daclizumab (Zenapax) Completed NCT02576145 Phase 4 Daclizumab
15 A Study of Peginterferon Alfa-2a (Pegasys) When Administered in Combination With Ribavirin in Patients With Chronic Hepatitis C (CHC) Completed NCT02641379 Phase 4 Peginterferon alfa-2a;Ribavirin
16 Pharmacokinetics of Levofloxacin in Intensive Care Unit Completed NCT02018081 Phase 4 Levofloxacin
17 Study to Measure Drug Satisfaction of Patients With Schizophrenia After Switching From Risperidone to Paliperidone Completed NCT00535132 Phase 4 Oral Risperidone;Paliperidone ER
18 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
19 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Combination With Copegus (Ribavirin) in Patients With Chronic Hepatitis C (CHC) Enrolled in a Methadone Maintenance Treatment Program. Completed NCT00087594 Phase 4 peginterferon alfa-2a [Pegasys];ribavirin
20 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Combination With Ribavirin in Patients With Chronic Hepatitis C (CHC) Previously Treated With PEG-Intron + Ribavirin Completed NCT00087568 Phase 4 Ribavirin;peginterferon alfa-2a [Pegasys]
21 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Combination With Adefovir or Entecavir in Patients With HBeAg-Positive Chronic Hepatitis B Completed NCT00922207 Phase 4 Adefovir;Entecavir;Placebo;peginterferon alfa-2a [Pegasys]
22 A Study of Once Monthly Bonviva (Ibandronate) in Prevention of Glucocorticoid-Induced Osteoporosis. Completed NCT00545051 Phase 4 Placebo;ibandronate
23 A Study of Bonviva (Ibandronate) Once Monthly in Post-Menopausal Women With Osteopenia Completed NCT00129623 Phase 4 Placebo;ibandronate [Bonviva/Boniva]
24 VICTOR Study - A Study of Valcyte (Valganciclovir po) Compared to Ganciclovir iv in Patients With Cytomegalovirus (CMV) Disease Who Are Solid Organ Transplant Recipients Completed NCT00431353 Phase 4 Ganciclovir;valganciclovir [Valcyte]
25 MAXIMA Study: A Study of Maintenance Therapy With MabThera (Rituximab) in Patients With Non-Hodgkin's Lymphoma. Completed NCT00430352 Phase 4 rituximab [MabThera/Rituxan]
26 A Study of NeoRecormon (Epoetin Beta) in Anemic Patients With Chronic Hepatitis C. Completed NCT00560274 Phase 4 Pegasys;Ribavirin;epoetin beta [NeoRecormon]
27 A Study of CellCept (Mycophenolate Mofetil) Combined With Calcineurin Inhibitors in Liver Transplant Patients. Completed NCT00717314 Phase 4 Mycophenolate mofetil;CNI (50%);CNI (≥75%)
28 Liver Spare the Nephron (STN) Study - A Study of CellCept (Mycophenolate Mofetil) and Sirolimus in Recipients of a Liver Transplant Completed NCT00118742 Phase 4 mycophenolate mofetil [CellCept];Tacrolimus;Cyclosporine;Sirolimus
29 A Study of CellCept (Mycophenolate Mofetil) Combined With Tacrolimus and Corticosteroids in Kidney Transplant Patients. Completed NCT00758602 Phase 4 mycophenolate mofetil;tacrolimus, standard dose;tacrolimus, low dose;corticosteroids
30 Pharmacogenetic Study of CellCept (Mycophenolate Mofetil) in Kidney Transplant Patients. Completed NCT00337493 Phase 4 mycophenolate mofetil [CellCept];mycophenolate mofetil [CellCept];Cyclosporine or tacrolimus;Cyclosporine or tacrolimus
31 REPEAT Study - A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) Therapy in Combination With COPEGUS (Ribavirin) in Patients With Chronic Hepatitis C (CHC) Who Did Not Respond to Previous PegIntron (Peginterferon Alfa-2b (12KD))/Ribavirin Combination Ther Completed NCT00087646 Phase 4 Ribavirin;Ribavirin;peginterferon alfa-2a [Pegasys];peginterferon alfa-2a [Pegasys];peginterferon alfa-2a [Pegasys];peginterferon alfa-2a [Pegasys]
32 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) Plus COPEGUS (Ribavirin) With or Without Pioglitazone in Treatment-Naive Patients With Chronic Hepatitis C and Insulin Resistance. Completed NCT00545233 Phase 4 peginterferon alfa-2a [Pegasys];ribavirin [Copegus];Pioglitazone
33 A Study of the Impact of an Early Biopsy in Patients Treated With CellCept (Mycophenolate Mofetil) After Kidney Transplantation Completed NCT00817687 Phase 4 mycophenolate mofetil [CellCept];mycophenolate mofetil [CellCept]
34 A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate Completed NCT01000610 Phase 4 rituximab [MabThera/Rituxan];methotrexate;methylprednisolone
35 A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Methotrexate Completed NCT00934648 Phase 4 rituximab [MabThera/Rituxan];methotrexate
36 A Clinical Study to Evaluate if Benzalkonium Chloride (BAK) in a Quinolone Eyedrop Reduces the Likelihood of Developing Resistant Organisms Completed NCT00874887 Phase 4 moxifloxacin 0.5% HCI ophthalmic solution;gatifloxacin ophthalmic solution 0.3%
37 Fecal Recovery of the Probiotic Bacteria Lactobacillus Rhamnosus GG (LGG) and Bifidobacterium Animalis Subspecies Lactis BB-12 (BB-12) in Healthy Humans Following Daily Consumption of a Probiotic Supplement Completed NCT01757054 Phase 4
38 A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis. Completed NCT00502853 Phase 4 rituximab [MabThera/Rituxan];Methotrexate
39 Topical Psoriasis Study for Patients Receiving Biologic Therapy Completed NCT02983981 Phase 4 Topicort Topical Spray
40 ADIponectin and Asymmetric Dimethylarginine (ADMA) Level in Type-2 Diabetes Patients After 12 Weeks of Treatment With GlimepiRide And Metformin Fixed Dose Combination Completed NCT01204580 Phase 4 GLIMEPIRIDE + METFORMIN
41 Clinical Trial on the Effects of Long Term Administration of 20% Albumin in the Cardiovascular and Renal Function, And Hepatic Hemodynamics in Advanced Patients With Cirrhosis and Ascites. Completed NCT00968695 Phase 4 Albumin
42 Pilot Study of the Rotavirus Vaccine in Infants With Intestinal Failure Completed NCT00995813 Phase 4
43 A Study of Safety and Effectiveness of Ultracet in Patients With Chronic Cancer Pain Completed NCT01968018 Phase 4 Tramadol HCI/acetaminophen
44 A Single Research Site Bile Acid Sequestrant Acceptability (BASA) Scale Pilot Validation Study Completed NCT01062269 Phase 4 Cholestyramine;Cholestyramine;Tang
45 Comparison of Colesevelam Hydrogen Chloride (HCl) Powder For Oral Suspension Versus Generic Cholestyramine Through Use of the Bile Acid Sequestrant Acceptability (BASA) Scale Completed NCT01122108 Phase 4 Cholestyramine;Colesevelam HCl
46 An Efficacy Study of Chlorhexidine Mouthwashes Completed NCT01751178 Phase 4 Chlorhexidine Digluconate Mouthwash with Alcohol;Chlorhexidine Digluconate Mouthwash without Alcohol
47 A Demonstration Project to Add Pre- or Post-exposure Prophylaxis to Combination HIV Prevention Services Completed NCT01781806 Phase 4 emtricitabine 200mg/tenofovir 300mg
48 The Use of 18F-ALF-NOTA-PRGD2 PET/CT Scan to Predict the Efficacy and Adverse Events of Apatinib in Malignancies. Completed NCT03384511 Phase 4 Apatinib
49 A Study to Compare Quality of Life and Satisfaction in Primary Immunodeficient Patients Treated With Subcutaneous Injections of Gammanorm® 165 mg/mL Administered With Two Different Delivery Devices: Injections Using Pump or Rapid Push Completed NCT02503293 Phase 4
50 Electrophysiological Effects of Guanfacine Extended Release in Attention Deficit Hyperactivity Disorder (ADHD) Completed NCT01069523 Phase 4 Guanfacine Extended Release;Placebo

Search NIH Clinical Center for Scoliosis, Isolated 1

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Genetic Tests for Scoliosis, Isolated 1

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Anatomical Context for Scoliosis, Isolated 1

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MalaCards organs/tissues related to Scoliosis, Isolated 1:

41
Bone, Lung, Liver, Brain, T Cells, Kidney, Eye
Sources

Publications for Scoliosis, Isolated 1

About this section

Articles related to Scoliosis, Isolated 1:

(show top 50) (show all 303)
# Title Authors Year
1
The effect of upper instrumented vertebra level on cervical sagittal alignment in Lenke 1 adolescent idiopathic scoliosis. ( 29933123 )
2018
2
Vertebral Axial Asymmetry in Adolescent Idiopathic Scoliosis. ( 29413732 )
2018
3
A National Analysis on Predictors of Discharge to Rehabilitation after Corrective Surgery for Adolescent Idiopathic Scoliosis. ( 29933335 )
2018
4
Dynamic ensemble selection of learner-descriptor classifiers to assess curve types in adolescent idiopathic scoliosis. ( 29949021 )
2018
5
Radiographic Methods to Estimate Surgical Outcomes based on Spinal Flexibility Assessment in Patients who have Adolescent Idiopathic Scoliosis: A Systematic Review. ( 29959103 )
2018
6
Curve Progression in Adolescent Idiopathic Scoliosis Does Not Match Skeletal Growth. ( 29389797 )
2018
7
Accuracy of thoracic pedicle screw placement using freehand technique and triggered EMG in adolescent idiopathic scoliosis: Is it different between concave and convex side? ( 29954289 )
2018
8
Circulating miRNAs as diagnostic biomarkers for adolescent idiopathic scoliosis. ( 29422531 )
2018
9
Association of vitamin D receptor BsmI rs1544410 and ApaI rs7975232 polymorphisms with susceptibility to adolescent idiopathic scoliosis: A systematic review and meta-analysis. ( 29480871 )
2018
10
Fulcrum flexibility of the main curve predicts postoperative shoulder imbalance in selective thoracic fusion of adolescent idiopathic scoliosis. ( 29931567 )
2018
11
Prevalence and impact of low body mass index on outcomes in patients with adolescent idiopathic scoliosis: a systematic review. ( 29434317 )
2018
12
Dose, image quality and spine modeling assessment of biplanar EOS micro-dose radiographs for the follow-up of in-brace adolescent idiopathic scoliosis patients. ( 29340779 )
2018
13
Shoulder Complex Mechanics in Adolescent Idiopathic Scoliosis and Their Relation to Patient-perceived Function. ( 29975295 )
2018
14
Proximal junctional kyphosis following correction surgery in the Lenke 5 adolescent idiopathic scoliosis patient. ( 29960823 )
2018
15
Sagittal plane assessment of spino-pelvic complex in a Central European population with adolescent idiopathic scoliosis: a case control study. ( 29942864 )
2018
16
Who Needs a Pediatric Intensive Care Unit After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis? ( 29413735 )
2018
17
Patterns of coronal curve changes in forward bending posture: a 3D ultrasound study of adolescent idiopathic scoliosis patients. ( 29943198 )
2018
18
Proximal junctional kyphosis in thoracic adolescent idiopathic scoliosis: risk factors and compensatory mechanisms in a multicenter national cohort. ( 29959554 )
2018
19
Criteria for Ending the Distal Fusion at the L3 Vertebra vs. L4 in Surgical Treatment of Adolescent Idiopathic Scoliosis Patients with Lenke Type 3C, 5C, and 6C Curves: Results After Ten Years of Follow-up. ( 29974019 )
2018
20
Supplementary Addendum to "Radiation dose of digital radiography (DR) versus micro-dose x-ray (EOS) on patients with adolescent idiopathic scoliosis: 2016 SOSORT- IRSSD "John Sevastic Award" Winner in Imaging Research". ( 29435497 )
2018
21
Analysis of sensory system aspects of postural stability during quiet standing in adolescent idiopathic scoliosis patients. ( 29929530 )
2018
22
Bone Mineral Density After Spinal Fusion Surgery for Adolescent Idiopathic Scoliosis at a Minimum 20-Year Follow-up. ( 29413740 )
2018
23
Blood Loss Trends and Financial Implications in Adolescent Idiopathic Scoliosis. ( 29979217 )
2018
24
CORR InsightsAr: Curve Progression in Adolescent Idiopathic Scoliosis Does Not Match Skeletal Growth. ( 29389798 )
2018
25
Variation in Adolescent Idiopathic Scoliosis Surgery: Implications for Improving Healthcare Value. ( 29426688 )
2018
26
Additional Risk Factors for Adding-On After Selective Thoracic Fusion in Adolescent Idiopathic Scoliosis: Implication of Lowest Instrumented Vertebra Angle and Lumbosacral Takeoff. ( 29413739 )
2018
27
Evidence-Based Thresholds for the Volume-Value Relationship in Adolescent Idiopathic Scoliosis: Outcomes and Economies of Scale. ( 29413738 )
2018
28
Uniplanar Versus Fixed Pedicle Screws in the Correction of Thoracic Kyphosis in the Treatment of Adolescent Idiopathic Scoliosis (AIS). ( 28060179 )
2017
29
Preventing Fusion Mass Shift Avoids Postoperative Distal Curve Adding-on in Adolescent Idiopathic Scoliosis. ( 28050819 )
2017
30
Asymmetry of the Vertebral Body and Pedicles in the True Transverse Plane in Adolescent Idiopathic Scoliosis: A CT-Based Study. ( 28038692 )
2017
31
Predictors for Postoperative Shoulder Balance in Lenke 1 Adolescent Idiopathic Scoliosis: A Prospective Cohort Study. ( 28038696 )
2017
32
Motivations for Compliance With Bracing in Adolescent Idiopathic Scoliosis. ( 28038693 )
2017
33
Lack of association between AKAP2 and the susceptibility of adolescent idiopathic scoliosis in the Chinese population. ( 28838314 )
2017
34
Spine Growth Modulation in Early Adolescent Idiopathic Scoliosis: Two-Year Results of Prospective US FDA IDE Pilot Clinical Safety Study of Titanium Clip-Screw Implant. ( 28882349 )
2017
35
Mutation of the Planar Cell Polarity Gene VANGL1 in Adolescent Idiopathic Scoliosis. ( 27755493 )
2017
36
Posture Alignment of Adolescent Idiopathic Scoliosis: Photogrammetry in Scoliosis School Screening. ( 28822476 )
2017
37
A Replication Study for the Association of rs11190870 With Curve Severity in Adolescent Idiopathic Scoliosis in Japanese. ( 28902104 )
2017
38
Scapular kinematics in adolescent idiopathic scoliosis: A three-dimensional motion analysis during multiplanar humeral elevation. ( 28823466 )
2017
39
Etiological Theories of Adolescent Idiopathic Scoliosis: Past and Present. ( 29399224 )
2017
40
National Trends in the Surgical Management of Adolescent Idiopathic Scoliosis: Analysis of a National Estimate of 60,108 Children From the National Inpatient Sample Over a 13-Year Time Period in the United States. ( 28038695 )
2017
41
Genome-wide association study identifies novel susceptible loci and highlights Wnt/beta-catenin pathway in the development of adolescent idiopathic scoliosis. ( 28334814 )
2017
42
The Role of Correction in the Conservative Treatment of Adolescent Idiopathic Scoliosis. ( 29399228 )
2017
43
A comparison of ultrasonography measurement on the abdominal muscles thickness between adolescent idiopathic scoliosis and healthy subjects. ( 28826167 )
2017
44
Spinal Manipulative Therapy for Adolescent Idiopathic Scoliosis: A Systematic Review. ( 28822477 )
2017
45
Distal adding-on phenomenon in adolescent idiopathic scoliosis patients with thoracolumbar vertebra fusion: A case-control study. ( 28930855 )
2017
46
Unique local bone tissue characteristics in iliac crest bone biopsy from adolescent idiopathic scoliosis with severe spinal deformity. ( 28054655 )
2017
47
Whether Orthotic Management and Exercise are Equally Effective to the Patients With Adolescent Idiopathic Scoliosis in Mainland China?: A Randomized Controlled Trial Study. ( 28885287 )
2017
48
Six-Month Follow-up of Supervised Spinal Stabilization Exercises for Low Back Pain in Adolescent Idiopathic Scoliosis. ( 27984472 )
2017
49
Impact of Scoliosis Severity on Functional Capacity in Patients with Adolescent Idiopathic Scoliosis. ( 28872419 )
2017
50
Genetic variant of BNC2 gene is functionally associated with adolescent idiopathic scoliosis in Chinese population. ( 28342042 )
2017
Sources

Variations for Scoliosis, Isolated 1

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ClinVar genetic disease variations for Scoliosis, Isolated 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MAPK7 NM_002749.3(MAPK7): c.886G> A (p.Ala296Thr) single nucleotide variant Pathogenic rs147296805 GRCh37 Chromosome 17, 19284408: 19284408
2 MAPK7 NM_002749.3(MAPK7): c.886G> A (p.Ala296Thr) single nucleotide variant Pathogenic rs147296805 GRCh38 Chromosome 17, 19381095: 19381095
3 MAPK7 NM_002749.3(MAPK7): c.1760C> T (p.Pro587Leu) single nucleotide variant Pathogenic rs758163506 GRCh38 Chromosome 17, 19382063: 19382063
4 MAPK7 NM_002749.3(MAPK7): c.1760C> T (p.Pro587Leu) single nucleotide variant Pathogenic rs758163506 GRCh37 Chromosome 17, 19285376: 19285376
5 MAPK7 NM_002749.3(MAPK7): c.1943C> T (p.Pro648Leu) single nucleotide variant Pathogenic GRCh37 Chromosome 17, 19285559: 19285559
6 MAPK7 NM_002749.3(MAPK7): c.1943C> T (p.Pro648Leu) single nucleotide variant Pathogenic GRCh38 Chromosome 17, 19382246: 19382246
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Expression for Scoliosis, Isolated 1

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Search GEO for disease gene expression data for Scoliosis, Isolated 1.
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Pathways for Scoliosis, Isolated 1

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GO Terms for Scoliosis, Isolated 1

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Sources for Scoliosis, Isolated 1

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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