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IS1
MCID: SCL057
MIFTS: 45

Scoliosis, Isolated 1 (IS1)

Categories: Bone diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Scoliosis, Isolated 1

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MalaCards integrated aliases for Scoliosis, Isolated 1:

Name: Scoliosis, Isolated 1 58
Adolescent Idiopathic Scoliosis 58 54 26 13 17
Scoliosis, Isolated, Susceptibility to, 1 58 6
Idiopathic Adolescent Scoliosis 77 54
Ais 58 26
Adolescent Isolated Scoliosis; Ais 58
Late Onset Idiopathic Scoliosis 26
Adolescent Isolated Scoliosis 58
Scoliosis, Idiopathic 1 58
Is1 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant vs. multifactorial


HPO:

33
scoliosis, isolated 1:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 58 181800
MedGen 43 C2700406
SNOMED-CT via HPO 70 111266001 263681008 64217002
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Summaries for Scoliosis, Isolated 1

About this section
NIH Rare Diseases : 54 Adolescent idiopathic scoliosis is an abnormal curvature of the spine that appears in late childhood or adolescence. Instead of growing straight, the spine develops a side-to-side curvature, usually in an elongated "s" or "C" shape, and the bones of the spine become slightly twisted or rotated. In many cases, the abnormal spinal curve is stable; however, in some children, the curve becomes more severe over time (progressive). For unknown reasons, severe and progressive curves occur more frequently in girls than in boys. The cause of adolescent idiopathic scoliosis is unknown. It is likely that there are both genetic and environmental factors involved. Treatment may include observation, bracing and/or surgery.

MalaCards based summary : Scoliosis, Isolated 1, also known as adolescent idiopathic scoliosis, is related to scoliosis and aland island eye disease. An important gene associated with Scoliosis, Isolated 1 is MAPK7 (Mitogen-Activated Protein Kinase 7). The drugs Thrombin and Parecoxib have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and t cells, and related phenotype is scoliosis.

Genetics Home Reference : 26 Adolescent idiopathic scoliosis is an abnormal curvature of the spine that appears in late childhood or adolescence. Instead of growing straight, the spine develops a side-to-side curvature, usually in an elongated "S" or "C" shape; the bones of the spine are also slightly twisted or rotated.

OMIM : 58 Idiopathic scoliosis is a structurally fixed lateral curvature of the spine with a rotatory component. There is at least a 10 degree curvature as demonstrated by upright spine roentgenograms by the Cobb method (Weinstein, 1994). Scoliosis may occur secondary to other hereditary disorders including Marfan syndrome (154700), dysautonomia (223900), neurofibromatosis (see 162200), Friedreich ataxia (see 229300), and muscular dystrophies. (181800)

Wikipedia : 77 Scoliosis is a medical condition in which a person''s spine has a sideways curve. The curve is usually... more...

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Related Diseases for Scoliosis, Isolated 1

About this section

Diseases in the Scoliosis, Isolated 1 family:

Scoliosis, Isolated 2 Scoliosis, Isolated 3
Scoliosis, Isolated 4 Scoliosis, Isolated 5

Diseases related to Scoliosis, Isolated 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 scoliosis 31.2 IS1 MAPK7
2 aland island eye disease 12.1
3 androgen insensitivity syndrome 12.1
4 amelogenesis imperfecta 12.0
5 autoimmune inner ear disease 11.9
6 aortic valve insufficiency 11.3
7 hereditary amyloidosis 11.3
8 childhood-onset cerebral x-linked adrenoleukodystrophy 11.3
9 idiopathic scoliosis 11.3
10 pediatric arterial ischemic stroke 11.2
11 amelogenesis imperfecta, type ib 11.2
12 scoliosis, isolated 3 11.1
13 scoliosis, isolated 4 11.1
14 scoliosis, isolated 5 11.1
15 salt and pepper developmental regression syndrome 11.1
16 jalili syndrome 11.0
17 amelogenesis imperfecta, type ie 11.0
18 amelogenesis imperfecta, type ij 11.0
19 body mass index quantitative trait locus 1 10.3
20 amyloidosis 10.3
21 adenocarcinoma 10.3
22 adenocarcinoma in situ 10.3
23 arteries, anomalies of 10.3
24 coronary artery anomaly 10.2
25 diabetes mellitus 10.2
26 bone mineral density quantitative trait locus 3 10.2
27 breast cancer 10.1
28 avian influenza 10.1
29 influenza 10.1
30 chiari malformation 10.1
31 degos 'en cocarde' erythrokeratoderma 10.1
32 ankyloblepharon filiforme adnatum and cleft palate 10.1
33 rapp-hodgkin syndrome 10.1
34 cerebrotendinous xanthomatosis 10.1
35 myoclonic epilepsy, familial infantile 10.1
36 spondyloocular syndrome 10.1
37 retinitis pigmentosa 4 10.1
38 buschke-ollendorff syndrome 10.1
39 bowenoid papulosis 10.1
40 cervical intraepithelial neoplasia 10.1
41 coronary heart disease 1 10.0
42 myocardial infarction 10.0
43 liver disease 10.0
44 endocervical adenocarcinoma 10.0
45 heart disease 10.0
46 head injury 10.0
47 marfan syndrome 10.0
48 osteoporosis 10.0
49 pectus excavatum 10.0
50 intraocular pressure quantitative trait locus 10.0

Graphical network of the top 20 diseases related to Scoliosis, Isolated 1:



Diseases related to Scoliosis, Isolated 1
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Symptoms & Phenotypes for Scoliosis, Isolated 1

About this section

Human phenotypes related to Scoliosis, Isolated 1:

33
# Description HPO Frequency HPO Source Accession
1 scoliosis 33 HP:0002650

Symptoms via clinical synopsis from OMIM:

58
Spine:
scoliosis

Clinical features from OMIM:

181800
Sources

Drugs & Therapeutics for Scoliosis, Isolated 1

About this section

Drugs for Scoliosis, Isolated 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 797)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 4
2
Parecoxib Approved Phase 4 198470-84-7
3
Sufentanil Approved, Investigational Phase 4,Not Applicable 56030-54-7 41693
4
Liraglutide Approved Phase 4,Phase 2 204656-20-2 44147092
5
tannic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1401-55-4
6
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
7
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 5311068 68602
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
9
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
10
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 2078-54-8 4943
11
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2 216974-75-3
12
Budesonide Approved Phase 4,Phase 3 51333-22-3 5281004 63006
13
Ipratropium Approved, Experimental Phase 4,Phase 2 22254-24-6, 60205-81-4 657309 43232
14
Terbutaline Approved Phase 4 23031-25-6 5403
15
Cobalt Approved, Experimental Phase 4,Not Applicable 7440-48-4 104729
16
Everolimus Approved Phase 4,Phase 3,Phase 2,Not Applicable 159351-69-6 70789204 6442177
17
Chromium Approved Phase 4,Not Applicable 7440-47-3 27668
18
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 22916-47-8 4189
19
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53123-88-9 46835353 5284616 6436030
20
Etomidate Approved Phase 4 33125-97-2 667484 36339
21
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
22
Glucosamine Approved, Investigational Phase 4,Phase 3,Not Applicable 3416-24-8 439213
23
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 62-31-7, 51-61-6 681
24
Mycophenolic acid Approved Phase 4,Phase 2,Not Applicable 24280-93-1 446541
25
Tacrolimus Approved, Investigational Phase 4,Phase 2,Not Applicable 104987-11-3 6473866 445643 439492
26
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 68-04-2
27
Losartan Approved Phase 4,Phase 1,Phase 2 114798-26-4 3961
28
Angiotensin II Approved, Investigational Phase 4,Phase 1,Phase 2 11128-99-7, 68521-88-0, 4474-91-3 172198
29
Levobupivacaine Approved, Investigational Phase 4,Not Applicable 27262-47-1 92253
30
Morphine Approved, Investigational Phase 4,Phase 2,Not Applicable 57-27-2 5288826
31
Opium Approved, Illicit Phase 4 8008-60-4
32
Methadone Approved, Illicit Phase 4 76-99-3 4095
33
Phenobarbital Approved, Investigational Phase 4 50-06-6 4763
34
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 93-14-1 3516
35
Loperamide Approved Phase 4,Phase 3,Phase 2 53179-11-6 3955
36
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
37
Chlorthalidone Approved Phase 4 77-36-1 2732
38
Ribavirin Approved Phase 4,Phase 2 36791-04-5 37542
39
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2 198153-51-4 5360545
40
Ofloxacin Approved Phase 4 82419-36-1 4583
41
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
42
Risperidone Approved, Investigational Phase 4,Phase 3 106266-06-2 5073
43
Aripiprazole Approved, Investigational Phase 4,Phase 3 129722-12-9 60795
44
Ziprasidone Approved Phase 4,Phase 3 146939-27-7 60854
45
Olanzapine Approved, Investigational Phase 4,Phase 3 132539-06-1 4585
46
Meperidine Approved Phase 4 57-42-1 4058
47
Peginterferon alfa-2b Approved Phase 4 215647-85-1, 99210-65-8
48
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
49
Adefovir dipivoxil Approved, Investigational Phase 4,Phase 3 142340-99-6 60871
50
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454

Interventional clinical trials:

(show top 50) (show all 902)
# Name Status NCT ID Phase Drugs
1 Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery Unknown status NCT01451788 Phase 4
2 Role of Parecoxib Sodium for Postoperative Pain Management in Open Hepatectomy Unknown status NCT02204878 Phase 4 Parecoxib Sodium
3 GLP-1 Analogue Treatment in Uncontrolled Type 1 Diabetic Patients Unknown status NCT01592279 Phase 4 liraglutide;Insulin injections
4 Sequential Use of Propofol/Midazolam and Dexmedetomidine for Sedation in Mechenical Ventialtion Patients in ICU. Unknown status NCT02122055 Phase 4 Fentanyl;Propofol;Midazolam;Dexmedetomidine
5 Coronary Angioplasty in Octogenarians With Emergent Coronary Syndromes Unknown status NCT02126202 Phase 4
6 Use of Bevacizumab to Modulate the Outcomes of Trabeculectomy Surgery Unknown status NCT01229202 Phase 4 Bevacizumab
7 Efficacy of Nebulized Pulmicort Respules in Primary Lung Cancer Patients With COPD Unknown status NCT02504801 Phase 4 Budesonide
8 Comparison of Strut Coverage With OPTIMAX Versus SYNERGY Stents Unknown status NCT02464397 Phase 4
9 The Feasibility of Different Doses of Etomidate Admixed With Propofol in Induced Abortion: A Randomized, Double Blind Controlled Trial Unknown status NCT02208596 Phase 4 pentazocine;propofol;Etomidate
10 Primary Care Study With Chondroitin Sulfate and Glucosamine Hydrochloride in Hand Osteoarhritis Unknown status NCT02823548 Phase 4 Droglican;Placebo
11 Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
12 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
13 Treatment of Neonatal Abstinence Syndrome Completed NCT01723722 Phase 4 Methadone;Diluted Deodorized Tincture of Opium
14 Tolerance to Target Doses of Thiazides in Actual Practice: A Feasibility Study Completed NCT01235377 Phase 4
15 A Study to Assess Immune Response in Pediatric Kidney Transplant Recipients Treated With Daclizumab (Zenapax) Completed NCT02576145 Phase 4 Daclizumab
16 A Study of Peginterferon Alfa-2a (Pegasys) When Administered in Combination With Ribavirin in Patients With Chronic Hepatitis C (CHC) Completed NCT02641379 Phase 4 Peginterferon alfa-2a;Ribavirin
17 Pharmacokinetics of Levofloxacin in Intensive Care Unit Completed NCT02018081 Phase 4 Levofloxacin
18 Preventing Relapse in Schizophrenia: Oral Antipsychotics Compared To Injectables: Evaluating Efficacy Completed NCT00330863 Phase 4 Risperidone microspheres;Risperidone;Olanzapine;Quetiapine;Ziprasidone;Aripiprazole;Paliperidone
19 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
20 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Combination With Copegus (Ribavirin) in Patients With Chronic Hepatitis C (CHC) Enrolled in a Methadone Maintenance Treatment Program. Completed NCT00087594 Phase 4 peginterferon alfa-2a [Pegasys];ribavirin
21 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Combination With Ribavirin in Patients With Chronic Hepatitis C (CHC) Previously Treated With PEG-Intron + Ribavirin Completed NCT00087568 Phase 4 Ribavirin;peginterferon alfa-2a [Pegasys]
22 Study to Measure Drug Satisfaction of Patients With Schizophrenia After Switching From Risperidone to Paliperidone Completed NCT00535132 Phase 4 Oral Risperidone;Paliperidone ER
23 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Combination With Adefovir or Entecavir in Patients With HBeAg-Positive Chronic Hepatitis B Completed NCT00922207 Phase 4 Adefovir;Entecavir;Placebo;peginterferon alfa-2a [Pegasys]
24 A Study of Bonviva (Ibandronate) Once Monthly in Post-Menopausal Women With Osteopenia Completed NCT00129623 Phase 4 Placebo;ibandronate [Bonviva/Boniva]
25 A Study of Once Monthly Bonviva (Ibandronate) in Prevention of Glucocorticoid-Induced Osteoporosis. Completed NCT00545051 Phase 4 Placebo;ibandronate
26 VICTOR Study - A Study of Valcyte (Valganciclovir po) Compared to Ganciclovir iv in Patients With Cytomegalovirus (CMV) Disease Who Are Solid Organ Transplant Recipients Completed NCT00431353 Phase 4 Ganciclovir;valganciclovir [Valcyte]
27 MAXIMA Study: A Study of Maintenance Therapy With MabThera (Rituximab) in Patients With Non-Hodgkin's Lymphoma. Completed NCT00430352 Phase 4 rituximab [MabThera/Rituxan]
28 A Study of NeoRecormon (Epoetin Beta) in Anemic Patients With Chronic Hepatitis C. Completed NCT00560274 Phase 4 Pegasys;Ribavirin;epoetin beta [NeoRecormon]
29 A Study of CellCept (Mycophenolate Mofetil) Combined With Calcineurin Inhibitors in Liver Transplant Patients. Completed NCT00717314 Phase 4 Mycophenolate mofetil;CNI (50%);CNI (≥75%)
30 Liver Spare the Nephron (STN) Study - A Study of CellCept (Mycophenolate Mofetil) and Sirolimus in Recipients of a Liver Transplant Completed NCT00118742 Phase 4 mycophenolate mofetil [CellCept];Tacrolimus;Cyclosporine;Sirolimus
31 A Study of CellCept (Mycophenolate Mofetil) Combined With Tacrolimus and Corticosteroids in Kidney Transplant Patients. Completed NCT00758602 Phase 4 mycophenolate mofetil;tacrolimus, standard dose;tacrolimus, low dose;corticosteroids
32 Pharmacogenetic Study of CellCept (Mycophenolate Mofetil) in Kidney Transplant Patients. Completed NCT00337493 Phase 4 mycophenolate mofetil [CellCept];mycophenolate mofetil [CellCept];Cyclosporine or tacrolimus;Cyclosporine or tacrolimus
33 REPEAT Study - A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) Therapy in Combination With COPEGUS (Ribavirin) in Patients With Chronic Hepatitis C (CHC) Who Did Not Respond to Previous PegIntron (Peginterferon Alfa-2b (12KD))/Ribavirin Combination Therapy Completed NCT00087646 Phase 4 Ribavirin;Ribavirin;peginterferon alfa-2a [Pegasys];peginterferon alfa-2a [Pegasys];peginterferon alfa-2a [Pegasys];peginterferon alfa-2a [Pegasys]
34 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) Plus COPEGUS (Ribavirin) With or Without Pioglitazone in Treatment-Naive Patients With Chronic Hepatitis C and Insulin Resistance. Completed NCT00545233 Phase 4 peginterferon alfa-2a [Pegasys];ribavirin [Copegus];Pioglitazone
35 A Study of the Impact of an Early Biopsy in Patients Treated With CellCept (Mycophenolate Mofetil) After Kidney Transplantation Completed NCT00817687 Phase 4 mycophenolate mofetil [CellCept];mycophenolate mofetil [CellCept]
36 A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate Completed NCT01000610 Phase 4 rituximab [MabThera/Rituxan];methotrexate;methylprednisolone
37 A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Methotrexate Completed NCT00934648 Phase 4 rituximab [MabThera/Rituxan];methotrexate
38 A Clinical Study to Evaluate if Benzalkonium Chloride (BAK) in a Quinolone Eyedrop Reduces the Likelihood of Developing Resistant Organisms Completed NCT00874887 Phase 4 moxifloxacin 0.5% HCI ophthalmic solution;gatifloxacin ophthalmic solution 0.3%
39 Fecal Recovery of the Probiotic Bacteria Lactobacillus Rhamnosus GG (LGG) and Bifidobacterium Animalis Subspecies Lactis BB-12 (BB-12) in Healthy Humans Following Daily Consumption of a Probiotic Supplement Completed NCT01757054 Phase 4
40 A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis. Completed NCT00502853 Phase 4 rituximab [MabThera/Rituxan];Methotrexate
41 Topical Psoriasis Study for Patients Receiving Biologic Therapy Completed NCT02983981 Phase 4 Topicort Topical Spray
42 ADIponectin and Asymmetric Dimethylarginine (ADMA) Level in Type-2 Diabetes Patients After 12 Weeks of Treatment With GlimepiRide And Metformin Fixed Dose Combination Completed NCT01204580 Phase 4 GLIMEPIRIDE + METFORMIN
43 Clinical Trial on the Effects of Long Term Administration of 20% Albumin in the Cardiovascular and Renal Function, And Hepatic Hemodynamics in Advanced Patients With Cirrhosis and Ascites. Completed NCT00968695 Phase 4 Albumin
44 Pilot Study of the Rotavirus Vaccine in Infants With Intestinal Failure Completed NCT00995813 Phase 4
45 A Study of Safety and Effectiveness of Ultracet in Patients With Chronic Cancer Pain Completed NCT01968018 Phase 4 Tramadol HCI/acetaminophen
46 A Single Research Site Bile Acid Sequestrant Acceptability (BASA) Scale Pilot Validation Study Completed NCT01062269 Phase 4 Cholestyramine;Cholestyramine;Tang
47 Comparison of Colesevelam Hydrogen Chloride (HCl) Powder For Oral Suspension Versus Generic Cholestyramine Through Use of the Bile Acid Sequestrant Acceptability (BASA) Scale Completed NCT01122108 Phase 4 Cholestyramine;Colesevelam HCl
48 An Efficacy Study of Chlorhexidine Mouthwashes Completed NCT01751178 Phase 4 Chlorhexidine Digluconate Mouthwash with Alcohol;Chlorhexidine Digluconate Mouthwash without Alcohol
49 A Demonstration Project to Add Pre- or Post-exposure Prophylaxis to Combination HIV Prevention Services Completed NCT01781806 Phase 4 emtricitabine 200mg/tenofovir 300mg
50 A Study to Compare Quality of Life and Satisfaction in Primary Immunodeficient Patients Treated With Subcutaneous Injections of Gammanorm® 165 mg/mL Administered With Two Different Delivery Devices: Injections Using Pump or Rapid Push Completed NCT02503293 Phase 4

Search NIH Clinical Center for Scoliosis, Isolated 1

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Genetic Tests for Scoliosis, Isolated 1

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Anatomical Context for Scoliosis, Isolated 1

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MalaCards organs/tissues related to Scoliosis, Isolated 1:

42
Bone, Brain, T Cells, Testes, Heart, Kidney, Eye
Sources

Publications for Scoliosis, Isolated 1

About this section

Articles related to Scoliosis, Isolated 1:

(show top 50) (show all 2386)
# Title Authors Year
1
Clinical Relevance of Preoperative MRI in Adolescent Idiopathic Scoliosis: Is Hydromyelia a Predictive Factor of Intraoperative Electrophysiological Monitoring Alterations? ( 30913042 )
2019
2
Accuracy of photogrammetry for detecting adolescent idiopathic scoliosis progression. ( 30661515 )
2019
3
Quantitative analysis of local bone graft harvested from the posterior elements during posterior spinal fusion in Adolescent Idiopathic Scoliosis patients. ( 30662243 )
2019
4
Surgical Outcomes of Anterior Versus Posterior Fusion in Lenke Type 1 Adolescent Idiopathic Scoliosis. ( 30664096 )
2019
5
Differential rod contouring on thoracolumbar/lumbar curvature in patients with adolescent idiopathic scoliosis: An analysis with intraoperative acquisition of three-dimensional imaging. ( 30683452 )
2019
6
Postoperative Lumbar Curve Progression Deteriorates Shoulder Imbalance in Patients with Lenke Type 2B/C Adolescent Idiopathic Scoliosis Who Underwent Selective Thoracic Fusion. ( 30684704 )
2019
7
Anterior Spinal Overgrowth of the Thoracic Spine May Not Be Involved in the Initiation of Adolescent Idiopathic Scoliosis. ( 30685373 )
2019
8
Sagittal Spinopelvic Alignment After Posterior Spinal Fusion in Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-analysis. ( 29889799 )
2019
9
Does fusion to T2 compared with T3/T4 lead to improved shoulder balance in adolescent idiopathic scoliosis with a double thoracic curve? ( 29851712 )
2019
10
The effect of Cobb angle correction on spinal length gain in patients with adolescent idiopathic scoliosis. ( 29697489 )
2019
11
Change of Sagittal Spinopelvic Parameters after Selective and Non-Selective Fusion in Lenke Type 1 Adolescent Idiopathic Scoliosis Patients. ( 29694667 )
2019
12
Thoracic Lordosis, Especially in Males, Increases Blood Loss in Adolescent Idiopathic Scoliosis. ( 30260921 )
2019
13
Costs and complications of increased length of stay following adolescent idiopathic scoliosis surgery. ( 30256316 )
2019
14
Standardized traction versus side-bending radiographs in adolescent idiopathic scoliosis: a preliminary study. ( 30252796 )
2019
15
Predictors of a Non-home Discharge Destination Following Spinal Fusion for Adolescent Idiopathic Scoliosis (AIS). ( 30247373 )
2019
16
Replication Study for the Association of GWAS-associated Loci With Adolescent Idiopathic Scoliosis Susceptibility and Curve Progression in a Chinese Population. ( 30234802 )
2019
17
Surgical increase in thoracic kyphosis increases unfused lumbar lordosis in selective fusion for thoracic adolescent idiopathic scoliosis. ( 30206693 )
2019
18
Significance of recumbent curvature in prediction of in-orthosis correction for adolescent idiopathic scoliosis. ( 30192710 )
2019
19
Do Overweight Adolescent Idiopathic Scoliosis (AIS) Patients Have an Increased Perioperative Risk for Posterior Spinal Fusion (PSF) Surgery?: A Propensity Score Matching Analysis of 374 AIS Patients. ( 30153211 )
2019
20
Observational retrospective study on socio-economic and quality of life outcomes in 41 patients with adolescent idiopathic scoliosis 5 years after bracing combined with physiotherapeutic scoliosis-specific exercises (PSSE). ( 30145658 )
2019
21
Spinal correction surgery improves asymmetrical trunk kinematics during gait in adolescent idiopathic scoliosis with thoracic major curve. ( 30145657 )
2019
22
Perioperative Outcome of Single Stage Posterior Spinal Fusion for Severe Adolescent Idiopathic Scoliosis (AIS) (Cobb Angle ≥90°): The Role of a Dual Attending Surgeon Strategy. ( 30130336 )
2019
23
Nighttime bracing with the Providence thoracolumbosacral orthosis for treatment of adolescent idiopathic scoliosis: A retrospective consecutive clinical series. ( 30101680 )
2019
24
Provider-Focused Intervention to Promote Comprehensive Screening for Adolescent Idiopathic Scoliosis by Primary Care Pediatricians. ( 30095983 )
2019
25
New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis. ( 30044367 )
2019
26
Modern Surgical Management of Early Onset and Adolescent Idiopathic Scoliosis. ( 30016462 )
2019
27
Dose Reduction Protocol for Full Spine X-ray Examination Using Copper Filters in Patients With Adolescent Idiopathic Scoliosis. ( 30005046 )
2019
28
Ponte Osteotomies Increase the Risk of Neuromonitoring Alerts in Adolescent Idiopathic Scoliosis Correction Surgery. ( 30005041 )
2019
29
The Natural Course of Compensatory Lumbar Curves in Nonoperated Patients With Thoracic Adolescent Idiopathic Scoliosis. ( 30005036 )
2019
30
A National Analysis on Predictors of Discharge to Rehabilitation After Corrective Surgery for Adolescent Idiopathic Scoliosis. ( 29933335 )
2019
31
Preoperative Sagittal Spinal Profile of Adolescent Idiopathic Scoliosis Lenke Types and Non-Scoliotic Adolescents: A Systematic Review and Meta-Analysis. ( 29927859 )
2019
32
Spine and Lower Extremity Kinematics Exhibited During Running by Adolescent Idiopathic Scoliosis Patients With Spinal Fusion. ( 30660219 )
2019
33
Global Sagittal Alignment and Proximal Junctional Kyphosis in Adolescent Idiopathic Scoliosis. ( 30660217 )
2019
34
Rare variant of HSPG2 is not involved in the development of adolescent idiopathic scoliosis: evidence from a large-scale replication study. ( 30646882 )
2019
35
Cervical spine alignment following surgery for adolescent idiopathic scoliosis (AIS): a pre-to-post analysis of 81 patients. ( 30646880 )
2019
36
The Reliability of Intraoperative Crossbar Technique in Determining the Upper Instrumented Vertebra (UIV) Tilt Angle for Adolescent Idiopathic Scoliosis (AIS) Undergoing Posterior Spinal Fusion. ( 30640749 )
2019
37
A stability-based model of a growing spine with adolescent idiopathic scoliosis: A combination of musculoskeletal and finite element approaches. ( 30638786 )
2019
38
Acute muscle stretching and the ability to maintain posture in females with adolescent idiopathic scoliosis. ( 30636726 )
2019
39
Is rasterstereography a valid noninvasive method for the screening of juvenile and adolescent idiopathic scoliosis? ( 30617835 )
2019
40
Back pain and outcomes of pregnancy after instrumented spinal fusion for adolescent idiopathic scoliosis. ( 30610987 )
2019
41
Predictive factors for brace treatment outcome in adolescent idiopathic scoliosis: a best-evidence synthesis. ( 30607519 )
2019
42
Three-Dimensional Computed Tomography Analysis of Spinal Canal Length Increase After Surgery for Adolescent Idiopathic Scoliosis: A Multicenter Study. ( 30601415 )
2019
43
The effect of orthotic interventions on balance performance in adolescent idiopathic scoliosis: A systematic literature review. ( 30601092 )
2019
44
Major Complications at Two Years After Surgery Impact SRS Scores for Adolescent Idiopathic Scoliosis Patients. ( 30587327 )
2019
45
Surgery for the Adolescent Idiopathic Scoliosis Patients After Skeletal Maturity: Early Versus Late Surgery. ( 30587326 )
2019
46
Patients' Perceptions of Breast Asymmetry Improve After Spinal Fusion for Adolescent Idiopathic Scoliosis. ( 30587325 )
2019
47
The 3D Sagittal Profile of Thoracic Versus Lumbar Major Curves in Adolescent Idiopathic Scoliosis. ( 30587322 )
2019
48
The Link Between the 3D Spino-pelvic Alignment and Vertebral Body morphology in Adolescent Idiopathic Scoliosis. ( 30587321 )
2019
49
Incidence of Intraspinal and Extraspinal MRI Abnormalities in Patients With Adolescent Idiopathic Scoliosis. ( 30587320 )
2019
50
Biomechanical Comparison of the Load-Sharing Capacity of High and Low Implant Density Constructs With Three Types of Pedicle Screws for the Instrumentation of Adolescent Idiopathic Scoliosis. ( 30587316 )
2019
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Variations for Scoliosis, Isolated 1

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ClinVar genetic disease variations for Scoliosis, Isolated 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MAPK7 NM_002749.3(MAPK7): c.886G> A (p.Ala296Thr) single nucleotide variant Pathogenic rs147296805 GRCh37 Chromosome 17, 19284408: 19284408
2 MAPK7 NM_002749.3(MAPK7): c.886G> A (p.Ala296Thr) single nucleotide variant Pathogenic rs147296805 GRCh38 Chromosome 17, 19381095: 19381095
3 MAPK7 NM_002749.3(MAPK7): c.1760C> T (p.Pro587Leu) single nucleotide variant Pathogenic rs758163506 GRCh37 Chromosome 17, 19285376: 19285376
4 MAPK7 NM_002749.3(MAPK7): c.1760C> T (p.Pro587Leu) single nucleotide variant Pathogenic rs758163506 GRCh38 Chromosome 17, 19382063: 19382063
5 MAPK7 NM_002749.3(MAPK7): c.1943C> T (p.Pro648Leu) single nucleotide variant Pathogenic rs1555613564 GRCh37 Chromosome 17, 19285559: 19285559
6 MAPK7 NM_002749.3(MAPK7): c.1943C> T (p.Pro648Leu) single nucleotide variant Pathogenic rs1555613564 GRCh38 Chromosome 17, 19382246: 19382246
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Expression for Scoliosis, Isolated 1

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Search GEO for disease gene expression data for Scoliosis, Isolated 1.
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Pathways for Scoliosis, Isolated 1

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GO Terms for Scoliosis, Isolated 1

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Sources for Scoliosis, Isolated 1

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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