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IS1
MCID: SCL057
MIFTS: 41

Scoliosis, Isolated 1 (IS1)

Categories: Bone diseases, Rare diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Scoliosis, Isolated 1

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MalaCards integrated aliases for Scoliosis, Isolated 1:

Name: Scoliosis, Isolated 1 56
Adolescent Idiopathic Scoliosis 56 52 25 13 17
Scoliosis, Isolated, Susceptibility to, 1 56 6
Idiopathic Adolescent Scoliosis 74 52
Ais 56 25
Adolescent Isolated Scoliosis; Ais 56
Late Onset Idiopathic Scoliosis 25
Adolescent Isolated Scoliosis 56
Scoliosis, Idiopathic 1 56
Is1 56

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant vs. multifactorial


HPO:

31
scoliosis, isolated 1:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases Bone diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 56 181800
MedGen 41 C2700406
SNOMED-CT via HPO 68 111266001 263681008 64217002
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Summaries for Scoliosis, Isolated 1

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Genetics Home Reference : 25 Adolescent idiopathic scoliosis is an abnormal curvature of the spine that appears in late childhood or adolescence. Instead of growing straight, the spine develops a side-to-side curvature, usually in an elongated "S" or "C" shape; the bones of the spine are also slightly twisted or rotated. Adolescent idiopathic scoliosis appears during the adolescent growth spurt, a time when children are growing rapidly. In many cases the abnormal spinal curve is stable, although in some children the curve is progressive (meaning it becomes more severe over time). For unknown reasons, severe and progressive curves occur more frequently in girls than in boys. However, mild spinal curvature is equally common in girls and boys. Mild scoliosis generally does not cause pain, problems with movement, or difficulty breathing. It may only be diagnosed if it is noticed during a regular physical examination or a scoliosis screening at school. The most common signs of the condition include a tilt or unevenness (asymmetry) in the shoulders, hips, or waist, or having one leg that appears longer than the other. A small percentage of affected children develop more severe, pronounced spinal curvature. Scoliosis can occur as a feature of other conditions, including a variety of genetic syndromes. However, adolescent idiopathic scoliosis typically occurs by itself, without signs and symptoms affecting other parts of the body.

MalaCards based summary : Scoliosis, Isolated 1, also known as adolescent idiopathic scoliosis, is related to scoliosis and androgen insensitivity syndrome. An important gene associated with Scoliosis, Isolated 1 is MAPK7 (Mitogen-Activated Protein Kinase 7). The drugs Thrombin and Morphine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and lung, and related phenotype is scoliosis.

NIH Rare Diseases : 52 Adolescent idiopathic scoliosis is an abnormal curvature of the spine that appears in late childhood or adolescence. Instead of growing straight, the spine develops a side-to-side curvature, usually in an elongated "s" or "C" shape, and the bones of the spine become slightly twisted or rotated. In many cases, the abnormal spinal curve is stable; however, in some children, the curve becomes more severe over time (progressive). For unknown reasons, severe and progressive curves occur more frequently in girls than in boys. The cause of adolescent idiopathic scoliosis is unknown. It is likely that there are both genetic and environmental factors involved. Treatment may include observation, bracing and/or surgery.

OMIM : 56 Idiopathic scoliosis is a structurally fixed lateral curvature of the spine with a rotatory component. There is at least a 10 degree curvature as demonstrated by upright spine roentgenograms by the Cobb method (Weinstein, 1994). Scoliosis may occur secondary to other hereditary disorders including Marfan syndrome (154700), dysautonomia (223900), neurofibromatosis (see 162200), Friedreich ataxia (see 229300), and muscular dystrophies. (181800)

Wikipedia : 74 Scoliosis is a medical condition in which a person's spine has a sideways curve. The curve is usually... more...

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Related Diseases for Scoliosis, Isolated 1

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Diseases in the Scoliosis, Isolated 1 family:

Scoliosis, Isolated 2 Scoliosis, Isolated 3
Scoliosis, Isolated 4 Scoliosis, Isolated 5

Diseases related to Scoliosis, Isolated 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 440)
# Related Disease Score Top Affiliating Genes
1 scoliosis 31.0 MAPK7 IS1
2 androgen insensitivity syndrome 12.3
3 aland island eye disease 12.3
4 amelogenesis imperfecta 12.1
5 autoimmune inner ear disease 12.0
6 amelogenesis imperfecta, type ib 11.6
7 hereditary amyloidosis 11.5
8 hidradenitis suppurativa 11.5
9 aortic valve insufficiency 11.5
10 x-linked cerebral adrenoleukodystrophy 11.4
11 idiopathic scoliosis 11.4
12 pediatric arterial ischemic stroke 11.3
13 jalili syndrome 11.3
14 scoliosis, isolated 3 11.2
15 scoliosis, isolated 4 11.2
16 scoliosis, isolated 5 11.2
17 salt and pepper developmental regression syndrome 11.2
18 amelogenesis imperfecta, type ie 11.1
19 amelogenesis imperfecta, type ij 11.1
20 non-alcoholic steatohepatitis 10.5
21 coronary heart disease 1 10.5
22 bone mineral density quantitative trait locus 3 10.5
23 atherosclerosis susceptibility 10.4
24 helix syndrome 10.4
25 huntington disease-like 3 10.4
26 amyloidosis 10.4
27 chiari malformation 10.4
28 huntington disease-like 2 10.4
29 coronary artery anomaly 10.4
30 pain agnosia 10.4
31 hyperlipoproteinemia, type iii 10.3
32 arteries, anomalies of 10.3
33 adenocarcinoma in situ 10.3
34 polykaryocytosis inducer 10.3
35 degenerative disc disease 10.3
36 virus-associated trichodysplasia spinulosa 10.3
37 avian influenza 10.3
38 hypertriglyceridemia, familial 10.3
39 respiratory failure 10.3
40 hand skill, relative 10.2
41 marfan syndrome 10.2
42 rickets 10.2
43 ileus 10.2
44 spinal cord injury 10.2
45 hypercholesterolemia, familial, 1 10.2
46 bone resorption disease 10.2
47 proline-negative auxotroph of hamster, complementation of 10.2
48 myoclonic epilepsy, familial infantile 10.2
49 allergic hypersensitivity disease 10.2
50 cystitis 10.2

Graphical network of the top 20 diseases related to Scoliosis, Isolated 1:



Diseases related to Scoliosis, Isolated 1
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Symptoms & Phenotypes for Scoliosis, Isolated 1

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Human phenotypes related to Scoliosis, Isolated 1:

31
# Description HPO Frequency HPO Source Accession
1 scoliosis 31 HP:0002650

Symptoms via clinical synopsis from OMIM:

56
Spine:
scoliosis

Clinical features from OMIM:

181800
Sources

Drugs & Therapeutics for Scoliosis, Isolated 1

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Drugs for Scoliosis, Isolated 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 4
2
Morphine Approved, Investigational Phase 4 57-27-2 5288826
3
Tranexamic Acid Approved Phase 4 1197-18-8 5526
4
Aminocaproic acid Approved, Investigational Phase 4 60-32-2 564
5
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
6
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
7
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
8
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
9
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
10 Hemostatics Phase 4
11 Coagulants Phase 4
12 Antifibrinolytic Agents Phase 4
13 Anesthetics Phase 4
14 Central Nervous System Depressants Phase 4
15 Hormones Phase 4
16 Calcium, Dietary Phase 4
17 Analgesics, Opioid Phase 4
18 Anesthetics, Local Phase 4
19 Anti-Arrhythmia Agents Phase 4
20 Sodium Channel Blockers Phase 4
21 Pharmaceutical Solutions Phase 4
22 Diuretics, Potassium Sparing Phase 4
23 Narcotics Phase 4
24 Tranquilizing Agents Phase 4
25 Anti-Anxiety Agents Phase 4
26 Psychotropic Drugs Phase 4
27 Anticonvulsants Phase 4
28 calcium channel blockers Phase 4
29 Acetylcholine Release Inhibitors Phase 4
30 Neurotransmitter Agents Phase 4
31 abobotulinumtoxinA Phase 4
32 Neuromuscular Agents Phase 4
33 Botulinum Toxins Phase 4
34 Cholinergic Agents Phase 4
35 Botulinum Toxins, Type A Phase 4
36
Calcium carbonate Approved, Investigational Phase 3 471-34-1
37 Gastrointestinal Agents Phase 3
38 Anti-Ulcer Agents Phase 3
39 Antacids Phase 3
40
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
41
Alfacalcidol Approved, Nutraceutical Phase 2 41294-56-8 5282181
42 Anesthetics, General Phase 1, Phase 2
43 Micronutrients Phase 2
44 Vitamins Phase 2
45 Trace Elements Phase 2
46 Nutrients Phase 2
47 Calciferol Phase 2
48 Hydroxycholecalciferols Phase 2
49
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
50
Ibuprofen Approved 15687-27-1 3672

Interventional clinical trials:

(show top 50) (show all 112)
# Name Status NCT ID Phase Drugs
1 Effectiveness Of Gelatin Matrix With Human Derived Thrombin On Blood Loss, Surgical Time, Hospital Stay And Complications In Adolescents Undergoing Spine Surgery For Adolescent Idiopathic Scoliosis: A Randomized Clinical Trial. Unknown status NCT01451788 Phase 4
2 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
3 Patient-controlled Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
4 A Prospective, Randomized, Double-blinded Single-site Control Study Comparing Blood Loss Prevention of Tranexamic Acid (TXA) to Epsilon Aminocaproic Acid (EACA) for Corrective Spinal Surgery Completed NCT00958581 Phase 4 Tranexamic Acid;Normal Saline;Epsilon aminocaproic acid
5 Intravenous Lidocaine to Reduce Postoperative Opioid Consumption and Improve Recovery After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Recruiting NCT03893318 Phase 4 IV lidocaine;Placebos
6 Effect of Pregabalin on Immediate Post-operative and Longterm Pain and Spinal Cord Monitoring in Children Undergoing Instrumented Spinal Surgery. Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
7 The Use of Botulinum Toxin A Injections As An Adjunct to Bracing to Treat Adolescent Idiopathic Scoliosis Not yet recruiting NCT03935295 Phase 4 AbobotulinumtoxinA;Placebos
8 A Multi-Centre Randomized Phase IV Clinical Trial Comparing Rods of Varying Yield Strengths and Their Ability to Hold Correction of Adolescent Idiopathic Scoliosis. Withdrawn NCT00768313 Phase 4
9 Can Calcium and Vitamin D Supplementation Improve Bone Mineral Density and Curve Progression in Girls With Adolescent Idiopathic Scoliosis? Completed NCT01103115 Phase 3
10 Improving Low Bone Mass With Vibration Therapy for Girls With Adolescent Idiopathic Scoliosis (AIS) - A Randomized Controlled Trial Completed NCT01108211 Phase 3
11 The Effects of Fibrinogen Concentrate Infusion on Perioperative Blood Loss and Allogeneic Blood Conservation in Patients Undergoing Scoliosis Surgery Recruiting NCT03183479 Phase 3 Fibrinogen Concentrate Human;Normal saline
12 Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis Active, not recruiting NCT02285621 Phase 3
13 Comparing the Moss Miami and Universal Spinal Instrumentation Systems for the Treatment of Adolescent Idiopathic Scoliosis Completed NCT00273598 Phase 2
14 The Efficacy of Intravenous Tranexamic Acid in Decreasing Blood Loss in Pediatric Idiopathic Scoliosis Surgery? Completed NCT01813058 Phase 1, Phase 2 Tranexamic Acid;Placebo
15 The Role of VitD in Rehabilitation of Idiopathic Adolescent Scoliosis Recruiting NCT03582917 Phase 2 Alphacalcidol
16 An Innovative Body-Mapping Tank Top Equipped With Biofeedback System for Adolescents With Early Scoliosis Completed NCT02471508 Phase 1
17 Impact of Age on Surgical Outcome of Adolescent Idiopathic Scoliosis Unknown status NCT02819245
18 A Randomized Controlled Trial: Comparison of a Top Loading MESA® Spinal System With MESA Rail™ and a Side Locking Pedicle Screw System for the Treatment of Adolescent Paediatric Spine Deformity Unknown status NCT02590380
19 Effect of the Severity and the Treatment (Orthosis Versus Surgery)of the Idiopathic Scoliosis on the Locomotor Mechanism of the Gait. Unknown status NCT00842218
20 Scoliosis-Specific Exercises for At-Risk Mild Adolescent Idiopathic Scoliosis Curves: A Multi-Site Preliminary Randomized Trial Unknown status NCT02807545
21 Evaluation of an Anesthetic Optimization Technique in Adolescent Idiopathic Scoliosis Surgery Completed NCT02481570
22 The Effect of Core Stabilization Training on Respiratory Parameters, Peripheral Muscle Strength, Balance, Functional Capacity and Quality of Life in Children With Adolescent Idiopathic Scoliosis Completed NCT03823053
23 Effect of Conservative Treatment on Pulmonary Functions, Gait Oxygen Consumption Balance and Lower Limb Load Distribution in Adolescents With Idiopathic Scoliosis Completed NCT03514082
24 A New 3D Geometrical Modelisation of Adolescent Idiopathic Scoliosis and Conception of a Personal Brace Completed NCT01336114
25 Single-blind Comprehensive Cohort Study Incorporating a Randomized Controlled Design on Bracing in AIS: A Feasibility Study Completed NCT00989495
26 Short-term Effects of the Simultaneous Use of Two Physiotherapeutic Methods in the Treatment of Adolescent Idiopathic Scoliosis - Pilot Study Completed NCT01250860
27 Prospective Study: Long-Term Pulmonary Function, Health-Related Quality of Life, and Sagittal Plane Alignment Following the Treatment of Pediatric Scoliosis Completed NCT01760434
28 Evaluation of Adam's Forward Bend Test and Smartphone Application in Screening of Adolescent Idiopathic Scoliosis Completed NCT04092335
29 Functional Testing, and Biomechanics Before and After Scoliosis Surgery Completed NCT02237248
30 Impact of Aerobic Training and Combined in Inflammatory Markers in Patients With Adolescent Idiopathic Scoliosis Completed NCT02413788
31 Pilot Study of Functional and Morphometric Brain Abnormalities Related to Adolescent Idiopathic Scoliosis (MOR-FO-SIA) Completed NCT02302534
32 Impact of Metal Density on Deformity Correction in Posterior Fusions for Adolescent Idiopathic Scoliosis Completed NCT04175145
33 Results of an Aerobic Exercising Program on Respiratory Muscle Strength in Patients With Adolescent Idiopathic Scoliosis: a Randomized, Controlled Trial Completed NCT00886652
34 The Effect of the Inspiratory Muscle Training on Respiratory Muscle Strength, Respiratory Function and Functional Capacity in Adolescents With Idiopathic Scoliosis Completed NCT03391895
35 Comparison of Dynamic Radiographs in Determining Fusion Level in Adolescent Idiopathic Scoliosis Correction Completed NCT03296228
36 Ghrelin Cellular Resistance Study in Adolescents With Idiopathic Scoliosis Completed NCT02829476
37 Assessment of Serum Vitamin D Levels in Surgical Adolescent Idiopathic Scoliosis Patients Completed NCT03820895
38 Core Stabilization Exercise Versus Scientific Exercises Approach to Scoliosis in the Treatment of Adolescent Idiopathic Scoliosis: A Randomized Single Blind Trial Completed NCT02978820
39 Lung Regeneration After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Completed NCT03539770
40 Screening and Prevalence of Adolescent Idiopathic Scoliosis in Selected Urban and Countryside Schools in Egypt Completed NCT03894865
41 Pedicle Screw Usage in Conventional Fixation Pattern Constructs Compared to Thoracic Hook Constructs in Adolescent Idiopathic Scoliosis Patients and Neuromuscular Ambulators Completed NCT01581021
42 Safety and Effectiveness Evaluation of the Minimal Invasive Deformity Correction (MID-C) System in Adolescent Idiopathic Scoliosis (AIS) Completed NCT03071471
43 Safety and Effectiveness Evaluation of the Minimal Invasive Deformity Correction (MID-C) System in Adolescent Idiopathic Scoliosis (AIS) Completed NCT03071445
44 Determine the Optimum Applied Pressure for the Brace Treatment of Scoliosis Completed NCT02996643 Early Phase 1
45 Genetic Evaluation for the Scoliosis Gene(s) in Patients With Neurofibromatosis 1 and Scoliosis Completed NCT01776125
46 Back Pain Management With Spinal Manipulation Therapy Compared to Usual Medical Care in Adolescent Idiopathic Scoliosis Patients: A Pilot Study Completed NCT02609009
47 Patients' Arm Positioning in the EOS® Stereoradiography System: Study the Sagittal Spinal Parameters and Postural Balance in EOS® Full Spine X-rays in Scoliosis Completed NCT02269657
48 End-growth Results of Tailored Treatment in 1938 Adolescents With High Risk Idiopathic Scoliosis: a Cohort Study From a Prospective Clinical Database Completed NCT03843216
49 Prevalence of Psychiatric Disorders in Adolescents With Idiopathic Scoliosis: A Pilot Study of a Validated Screening Tool Completed NCT00445393
50 Investigation of the Effects of Spinal Stabilization and Body Awareness Exercises on Subjective Vertical Perception, Curve Magnitude, Body Symmetry and Quality of Life in Adolescent Idiopathic Scoliosis Completed NCT02552615

Search NIH Clinical Center for Scoliosis, Isolated 1

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Genetic Tests for Scoliosis, Isolated 1

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Anatomical Context for Scoliosis, Isolated 1

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MalaCards organs/tissues related to Scoliosis, Isolated 1:

40
Bone, Testes, Lung, Spinal Cord, Heart, Brain, Breast
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Publications for Scoliosis, Isolated 1

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Articles related to Scoliosis, Isolated 1:

(show top 50) (show all 3943)
# Title Authors PMID Year
1
A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis. 61 56
26211971 2015
2
Polygenic inheritance of adolescent idiopathic scoliosis: a study of extended families in Utah. 61 56
20425822 2010
3
A genetic locus for adolescent idiopathic scoliosis linked to chromosome 19p13.3. 61 56
12094330 2002
4
Evaluation of the adolescent or adult with some features of Marfan syndrome. 6
22237449 2012
5
Identification of susceptibility loci for scoliosis in FIS families with triple curves. 56
20358593 2010
6
Segregation analysis of idiopathic scoliosis: demonstration of a major gene effect. 56
10494097 1999
7
Idiopathic scoliosis in twins studied by DNA fingerprinting: the incidence and type of scoliosis. 56
9546446 1998
8
Autosomal dominant idiopathic scoliosis? 56
7702081 1995
9
Genetic aspects of early childhood scoliosis. 56
3300334 1987
10
Scoliosis in chickens: responsiveness of severity and incidence to dietary copper. 56
6740317 1984
11
Collagen defect in idiopathic scoliosis. 56
78312 1978
12
Genetic aspects of idiopathic scoliosis. A Nicholas Andry Award essay, 1970. 56
5047777 1972
13
Familial (idiopathic) scoliosis. A family survey. 56
5641594 1968
14
Idiopathic scoliosis: genetic and environmental aspects. 56
6082901 1967
15
[Medical aspects of essential structural scoliosis in children]. 56
13947961 1963
16
HEREDITARY SCOLIOSIS. 56
20778092 1934
17
Idiopathic scoliosis: A pilot MR study of early vertebral morphological changes and spinal asymmetry. 61
32025128 2020
18
The Influence of Body Habitus on Documented Brace Wear and Progression in Adolescents With Idiopathic Scoliosis. 61
31259783 2020
19
Is It Growth or Natural History? Increasing Spinal Deformity After Sanders Stage 7 in Females With AIS. 61
31181026 2020
20
High Satisfaction in Adolescent Idiopathic Scoliosis Patients on Enhanced Discharge Pathway. 61
31403990 2020
21
Is Anterior Release Obsolete or Does It Play a Role in Contemporary Adolescent Idiopathic Scoliosis Surgery? A Matched Pair Analysis. 61
31368923 2020
22
Demonstration of asymmetric muscle perfusion of the back after exercise in patients with adolescent idiopathic scoliosis using intravoxel incoherent motion (IVIM) MRI. 61
31815323 2020
23
The 100 Top-Cited Articles on Spinal Deformity: A Bibliometric Analysis. 61
31999653 2020
24
Multimodal pain control in adolescent posterior spinal fusion patients: a double-blind, randomized controlled trial to validate the effect of gabapentin on postoperative pain control, opioid use, and patient satisfaction. 61
32026435 2020
25
Risk Factors for Postoperative Distal Adding-on in Lenke Type 1B and 1C and its Influence on Residual Lumbar Curve. 61
31095011 2020
26
Preemptive Pregabalin in Children and Adolescents Undergoing Posterior Instrumented Spinal Fusion: A Double-Blinded, Placebo-Controlled, Randomized Clinical Trial. 61
31770296 2020
27
FoxD1-driven CCN2 deletion causes axial skeletal deformities, pulmonary hypoplasia, and neonatal asphyctic death. 61
32020419 2020
28
Anaphylaxis secondary to albumin infusion during posterior spinal fusion for pediatric scoliosis. 61
32030641 2020
29
Patient-reported Outcomes Following Surgical Intervention for Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-Analysis. 61
30925497 2020
30
A Novel Coding Variant in SLC39A8 Is Associated With Adolescent Idiopathic Scoliosis in Chinese Han Population. 61
31513097 2020
31
Does Curve Regression Occur During Underarm Bracing in Patients with Adolescent Idiopathic Scoliosis? 61
31688210 2020
32
CORR Insights®: Does Curve Regression Occur During Underarm Bracing in Patients with Adolescent Idiopathic Scoliosis? 61
31794490 2020
33
Supine flexibility predicts curve progression for patients with adolescent idiopathic scoliosis undergoing underarm bracing. 61
32009436 2020
34
What's Important: Moving Beyond "Idiopathic" in Adolescent Idiopathic Scoliosis. 61
31725121 2020
35
Rib Regeneration Morphology After Thoracoplasty in Adolescent Idiopathic Scoliosis. 61
31464973 2020
36
Towards a new 3D classification for adolescent idiopathic scoliosis. 61
32026444 2020
37
Surface topography assessment of body shape after surgical correction in adolescent idiopathic scoliosis. 61
32030642 2020
38
Use of a novel corrective device for correction of deformities in adolescent idiopathic scoliosis. 61
31104287 2020
39
Patient-specific rods for thoracic kyphosis correction in adolescent idiopathic scoliosis surgery: Preliminary results. 61
31757655 2020
40
Fusions ending at the thoracolumbar junction in adolescent idiopathic scoliosis: comparison of lower instrumented vertebrae. 61
32026437 2020
41
Establishing consensus on the best practice guidelines for the use of bracing in adolescent idiopathic scoliosis. 61
32026441 2020
42
Safety and Effectiveness of Antifibrinolytics in Posterior Scoliosis Surgery for Adolescent Idiopathic Scoliosis: An Analysis of the NSQIP-Pediatric Database. 61
31162181 2020
43
What is the most reliable radiographic method to evaluate the longitudinal foot arch? Application in subjects with Adolescent Idiopathic Scoliosis. 61
32035816 2020
44
Changes in the Position of the Junctional Vertebrae After Posterior Spinal Fusion in Adolescent Idiopathic Scoliosis: Implication in Risk Assessment of Proximal Junctional Kyphosis Development. 61
31095012 2020
45
High Risk of Mismatch Between Sanders and Risser Staging in Adolescent Idiopathic Scoliosis: Are We Guiding Treatment Using the Wrong Classification? 61
31923164 2020
46
A Positive (+ve) Postoperative Upper Instrumented Vertebra Tilt Angle (≥0°) Significantly Increases the Risk of Medial Shoulder and Neck Imbalance in Lenke 1 and 2 Adolescent Idiopathic Scoliosis Patients. 61
32032325 2020
47
Revision surgery in distal junctional kyphosis. 61
31993790 2020
48
Multimodal Intraoperative Spinal Cord Monitoring during Spinal Deformity Surgery: Efficacy, Diagnostic Characteristics, and Algorithm Development. 61
31158841 2020
49
Emerging Techniques in Diagnostic Imaging for Idiopathic Scoliosis in Children and Adolescents: A Review of the Literature. 61
31954891 2020
50
Answer to the Letter to the Editor of M. A. Potts concerning "Providence nighttime bracing is effective in treatment for adolescent idiopathic scoliosis even in curves larger than 35°" by Simony A, Beuschau I, Quisth L, et al. [Eur Spine J; (2019): https://doi.org/10.1007/s00586-019-06077-z]. 61
31919644 2020
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Variations for Scoliosis, Isolated 1

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ClinVar genetic disease variations for Scoliosis, Isolated 1:

6 ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 MAPK7 NM_002749.4(MAPK7):c.886G>A (p.Ala296Thr)SNV Pathogenic 427639 rs147296805 17:19284408-19284408 17:19381095-19381095
2 MAPK7 NM_002749.4(MAPK7):c.1760C>T (p.Pro587Leu)SNV Pathogenic 427640 rs758163506 17:19285376-19285376 17:19382063-19382063
3 MAPK7 NM_002749.4(MAPK7):c.1943C>T (p.Pro648Leu)SNV Pathogenic 427641 rs1555613564 17:19285559-19285559 17:19382246-19382246
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Expression for Scoliosis, Isolated 1

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Search GEO for disease gene expression data for Scoliosis, Isolated 1.
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Pathways for Scoliosis, Isolated 1

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GO Terms for Scoliosis, Isolated 1

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Sources for Scoliosis, Isolated 1

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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