AIS
MCID: SCL057
MIFTS: 46

Scoliosis, Isolated 1 (AIS)

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Scoliosis, Isolated 1

MalaCards integrated aliases for Scoliosis, Isolated 1:

Name: Scoliosis, Isolated 1 58
Adolescent Idiopathic Scoliosis 58 54 26 17
Scoliosis, Isolated, Susceptibility to, 1 58 6
Idiopathic Adolescent Scoliosis 77 54
Scoliosis, Idiopathic 1 58 13
Ais 58 26
Adolescent Isolated Scoliosis; Ais 58
Late Onset Idiopathic Scoliosis 26
Adolescent Isolated Scoliosis 58
Is1 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant vs. multifactorial


Classifications:



External Ids:

OMIM 58 181800
MedGen 43 C2700406
SNOMED-CT via HPO 70 111266001 64217002

Summaries for Scoliosis, Isolated 1

NIH Rare Diseases : 54 Adolescent idiopathic scoliosis is an abnormal curvature of the spine that appears in late childhood or adolescence. Instead of growing straight, the spine develops a side-to-side curvature, usually in an elongated "s" or "C" shape, and the bones of the spine become slightly twisted or rotated. In many cases, the abnormal spinal curve is stable; however, in some children, the curve becomes more severe over time (progressive). For unknown reasons, severe and progressive curves occur more frequently in girls than in boys. The cause of adolescent idiopathic scoliosis is unknown. It is likely that there are both genetic and environmental factors involved. Treatment may include observation, bracing and/or surgery.

MalaCards based summary : Scoliosis, Isolated 1, also known as adolescent idiopathic scoliosis, is related to scoliosis and androgen insensitivity syndrome. An important gene associated with Scoliosis, Isolated 1 is MAPK7 (Mitogen-Activated Protein Kinase 7). The drugs Thrombin and Parecoxib have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and t cells, and related phenotype is scoliosis.

Genetics Home Reference : 26 Adolescent idiopathic scoliosis is an abnormal curvature of the spine that appears in late childhood or adolescence. Instead of growing straight, the spine develops a side-to-side curvature, usually in an elongated "S" or "C" shape; the bones of the spine are also slightly twisted or rotated.

OMIM : 58 Idiopathic scoliosis is a structurally fixed lateral curvature of the spine with a rotatory component. There is at least a 10 degree curvature as demonstrated by upright spine roentgenograms by the Cobb method (Weinstein, 1994). Scoliosis may occur secondary to other hereditary disorders including Marfan syndrome (154700), dysautonomia (223900), neurofibromatosis (see 162200), Friedreich ataxia (see 229300), and muscular dystrophies. (181800)

Wikipedia : 77 Scoliosis is a medical condition in which a person''s spine has a sideways curve. The curve is usually... more...

Related Diseases for Scoliosis, Isolated 1

Diseases in the Scoliosis, Isolated 1 family:

Scoliosis, Isolated 2 Scoliosis, Isolated 3
Scoliosis, Isolated 4 Scoliosis, Isolated 5

Diseases related to Scoliosis, Isolated 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 scoliosis 31.1 IS1 MAPK7
2 androgen insensitivity syndrome 12.0
3 amelogenesis imperfecta 12.0
4 autoimmune inner ear disease 11.9
5 aland island eye disease 11.9
6 hereditary amyloidosis 11.3
7 aortic valve insufficiency 11.3
8 childhood-onset cerebral x-linked adrenoleukodystrophy 11.3
9 idiopathic scoliosis 11.3
10 pediatric arterial ischemic stroke 11.2
11 amelogenesis imperfecta, type ib 11.2
12 scoliosis, isolated 3 11.1
13 scoliosis, isolated 4 11.1
14 scoliosis, isolated 5 11.1
15 salt and pepper developmental regression syndrome 11.0
16 jalili syndrome 11.0
17 amelogenesis imperfecta, type ie 11.0
18 amelogenesis imperfecta, type ij 11.0
19 alzheimer disease 10.8
20 amyloidosis 10.4
21 body mass index quantitative trait locus 1 10.3
22 adenocarcinoma 10.3
23 dementia 10.2
24 adenocarcinoma in situ 10.2
25 cerebral amyloid angiopathy, cst3-related 10.2
26 arteries, anomalies of 10.2
27 coronary artery anomaly 10.2
28 bone mineral density quantitative trait locus 3 10.2
29 diabetes mellitus 10.1
30 cerebrotendinous xanthomatosis 10.1
31 spondyloocular syndrome 10.1
32 retinitis pigmentosa 4 10.1
33 disease of mental health 10.1
34 chiari malformation 10.1
35 degos 'en cocarde' erythrokeratoderma 10.1
36 neuroblastoma 10.1
37 avian influenza 10.1
38 influenza 10.1
39 depression 10.1
40 breast cancer 10.0
41 inclusion body myositis 10.0
42 myositis 10.0
43 aging 10.0
44 thalassemia 10.0
45 dysfibrinogenemia 10.0
46 marfan syndrome 10.0
47 osteoporosis 10.0
48 pectus excavatum 10.0
49 intraocular pressure quantitative trait locus 10.0
50 alkuraya-kucinskas syndrome 10.0

Graphical network of the top 20 diseases related to Scoliosis, Isolated 1:



Diseases related to Scoliosis, Isolated 1

Symptoms & Phenotypes for Scoliosis, Isolated 1

Human phenotypes related to Scoliosis, Isolated 1:

33
# Description HPO Frequency HPO Source Accession
1 scoliosis 33 HP:0002650

Symptoms via clinical synopsis from OMIM:

58
Spine:
scoliosis

Clinical features from OMIM:

181800

Drugs & Therapeutics for Scoliosis, Isolated 1

Drugs for Scoliosis, Isolated 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 793)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 4
2
Parecoxib Approved Phase 4 198470-84-7
3
Sufentanil Approved, Investigational Phase 4,Not Applicable 56030-54-7 41693
4
Liraglutide Approved Phase 4,Phase 2 204656-20-2 44147092
5
tannic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1401-55-4
6
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
7
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
9
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
10
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 2078-54-8 4943
11
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2 216974-75-3
12
Budesonide Approved Phase 4,Phase 3 51333-22-3 63006 5281004
13
Terbutaline Approved Phase 4 23031-25-6 5403
14
Ipratropium Approved Phase 4,Phase 2 60205-81-4, 22254-24-6 43232 657309
15
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53123-88-9 46835353 6436030 5284616
16
Cobalt Approved, Experimental Phase 4,Not Applicable 7440-48-4 104729
17
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 22916-47-8 4189
18
Chromium Approved Phase 4,Not Applicable 7440-47-3 27668
19
Everolimus Approved Phase 4,Phase 3,Phase 2,Not Applicable 159351-69-6 6442177 70789204
20
Etomidate Approved Phase 4 33125-97-2 36339 667484
21
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
22
Glucosamine Approved, Investigational Phase 4,Phase 3,Not Applicable 3416-24-8 439213
23
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 62-31-7, 51-61-6 681
24
Mycophenolic acid Approved Phase 4,Phase 2,Not Applicable 24280-93-1 446541
25
Tacrolimus Approved, Investigational Phase 4,Phase 2,Not Applicable 104987-11-3 445643 439492 6473866
26
Alprostadil Approved, Investigational Phase 4,Phase 2,Phase 3 745-65-3 149351 5280723
27
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 68-04-2
28
Levobupivacaine Approved, Investigational Phase 4,Not Applicable 27262-47-1 92253
29
Morphine Approved, Investigational Phase 4,Phase 2,Not Applicable 57-27-2 5288826
30
Loperamide Approved Phase 4,Phase 3,Phase 2 53179-11-6 3955
31
Opium Approved, Illicit Phase 4 8008-60-4
32
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 93-14-1 3516
33
Methadone Approved Phase 4 76-99-3 4095
34
Phenobarbital Approved, Investigational Phase 4 50-06-6 4763
35
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
36
Chlorthalidone Approved Phase 4 77-36-1 2732
37
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2 198153-51-4 5360545
38
Ribavirin Approved Phase 4,Phase 2 36791-04-5 37542
39
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
40
Ofloxacin Approved Phase 4 82419-36-1 4583
41
Ziprasidone Approved Phase 4,Phase 3 146939-27-7 60854
42
Aripiprazole Approved, Investigational Phase 4,Phase 3 129722-12-9 60795
43
Olanzapine Approved, Investigational Phase 4,Phase 3 132539-06-1 4585
44
Risperidone Approved, Investigational Phase 4,Phase 3 106266-06-2 5073
45
Meperidine Approved Phase 4 57-42-1 4058
46
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
47
Adefovir Dipivoxil Approved, Investigational Phase 4,Phase 3 142340-99-6 60871
48
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
49
Valganciclovir Approved, Investigational Phase 4 175865-60-8 64147
50
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454

Interventional clinical trials:

(show top 50) (show all 881)
# Name Status NCT ID Phase Drugs
1 Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery Unknown status NCT01451788 Phase 4
2 Role of Parecoxib Sodium for Postoperative Pain Management in Open Hepatectomy Unknown status NCT02204878 Phase 4 Parecoxib Sodium
3 GLP-1 Analogue Treatment in Uncontrolled Type 1 Diabetic Patients Unknown status NCT01592279 Phase 4 liraglutide;Insulin injections
4 Sequential Use of Propofol/Midazolam and Dexmedetomidine for Sedation in Mechenical Ventialtion Patients in ICU. Unknown status NCT02122055 Phase 4 Fentanyl;Propofol;Midazolam;Dexmedetomidine
5 Coronary Angioplasty in Octogenarians With Emergent Coronary Syndromes Unknown status NCT02126202 Phase 4
6 Use of Bevacizumab to Modulate the Outcomes of Trabeculectomy Surgery Unknown status NCT01229202 Phase 4 Bevacizumab
7 Efficacy of Nebulized Pulmicort Respules in Primary Lung Cancer Patients With COPD Unknown status NCT02504801 Phase 4 Budesonide
8 Comparison of Strut Coverage With OPTIMAX Versus SYNERGY Stents Unknown status NCT02464397 Phase 4
9 The Feasibility of Different Doses of Etomidate Admixed With Propofol in Induced Abortion: A Randomized, Double Blind Controlled Trial Unknown status NCT02208596 Phase 4 pentazocine;propofol;Etomidate
10 Primary Care Study With Chondroitin Sulfate and Glucosamine Hydrochloride in Hand Osteoarhritis Unknown status NCT02823548 Phase 4 Droglican;Placebo
11 Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
12 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
13 Treatment of Neonatal Abstinence Syndrome Completed NCT01723722 Phase 4 Methadone;Diluted Deodorized Tincture of Opium
14 Tolerance to Target Doses of Thiazides in Actual Practice: A Feasibility Study Completed NCT01235377 Phase 4
15 A Study to Assess Immune Response in Pediatric Kidney Transplant Recipients Treated With Daclizumab (Zenapax) Completed NCT02576145 Phase 4 Daclizumab
16 A Study of Peginterferon Alfa-2a (Pegasys) When Administered in Combination With Ribavirin in Patients With Chronic Hepatitis C (CHC) Completed NCT02641379 Phase 4 Peginterferon alfa-2a;Ribavirin
17 Pharmacokinetics of Levofloxacin in Intensive Care Unit Completed NCT02018081 Phase 4 Levofloxacin
18 Preventing Relapse in Schizophrenia: Oral Antipsychotics Compared To Injectables: Evaluating Efficacy Completed NCT00330863 Phase 4 Risperidone microspheres;Risperidone;Olanzapine;Quetiapine;Ziprasidone;Aripiprazole;Paliperidone
19 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
20 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Combination With Copegus (Ribavirin) in Patients With Chronic Hepatitis C (CHC) Enrolled in a Methadone Maintenance Treatment Program. Completed NCT00087594 Phase 4 peginterferon alfa-2a [Pegasys];ribavirin
21 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Combination With Ribavirin in Patients With Chronic Hepatitis C (CHC) Previously Treated With PEG-Intron + Ribavirin Completed NCT00087568 Phase 4 Ribavirin;peginterferon alfa-2a [Pegasys]
22 Study to Measure Drug Satisfaction of Patients With Schizophrenia After Switching From Risperidone to Paliperidone Completed NCT00535132 Phase 4 Oral Risperidone;Paliperidone ER
23 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Combination With Adefovir or Entecavir in Patients With HBeAg-Positive Chronic Hepatitis B Completed NCT00922207 Phase 4 Adefovir;Entecavir;Placebo;peginterferon alfa-2a [Pegasys]
24 A Study of Bonviva (Ibandronate) Once Monthly in Post-Menopausal Women With Osteopenia Completed NCT00129623 Phase 4 Placebo;ibandronate [Bonviva/Boniva]
25 A Study of Once Monthly Bonviva (Ibandronate) in Prevention of Glucocorticoid-Induced Osteoporosis. Completed NCT00545051 Phase 4 Placebo;ibandronate
26 VICTOR Study - A Study of Valcyte (Valganciclovir po) Compared to Ganciclovir iv in Patients With Cytomegalovirus (CMV) Disease Who Are Solid Organ Transplant Recipients Completed NCT00431353 Phase 4 Ganciclovir;valganciclovir [Valcyte]
27 MAXIMA Study: A Study of Maintenance Therapy With MabThera (Rituximab) in Patients With Non-Hodgkin's Lymphoma. Completed NCT00430352 Phase 4 rituximab [MabThera/Rituxan]
28 A Study of NeoRecormon (Epoetin Beta) in Anemic Patients With Chronic Hepatitis C. Completed NCT00560274 Phase 4 Pegasys;Ribavirin;epoetin beta [NeoRecormon]
29 A Study of CellCept (Mycophenolate Mofetil) Combined With Calcineurin Inhibitors in Liver Transplant Patients. Completed NCT00717314 Phase 4 Mycophenolate mofetil;CNI (50%);CNI (≥75%)
30 Liver Spare the Nephron (STN) Study - A Study of CellCept (Mycophenolate Mofetil) and Sirolimus in Recipients of a Liver Transplant Completed NCT00118742 Phase 4 mycophenolate mofetil [CellCept];Tacrolimus;Cyclosporine;Sirolimus
31 A Study of CellCept (Mycophenolate Mofetil) Combined With Tacrolimus and Corticosteroids in Kidney Transplant Patients. Completed NCT00758602 Phase 4 mycophenolate mofetil;tacrolimus, standard dose;tacrolimus, low dose;corticosteroids
32 Pharmacogenetic Study of CellCept (Mycophenolate Mofetil) in Kidney Transplant Patients. Completed NCT00337493 Phase 4 mycophenolate mofetil [CellCept];mycophenolate mofetil [CellCept];Cyclosporine or tacrolimus;Cyclosporine or tacrolimus
33 REPEAT Study - A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) Therapy in Combination With COPEGUS (Ribavirin) in Patients With Chronic Hepatitis C (CHC) Who Did Not Respond to Previous PegIntron (Peginterferon Alfa-2b (12KD))/Ribavirin Combination Therapy Completed NCT00087646 Phase 4 Ribavirin;Ribavirin;peginterferon alfa-2a [Pegasys];peginterferon alfa-2a [Pegasys];peginterferon alfa-2a [Pegasys];peginterferon alfa-2a [Pegasys]
34 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) Plus COPEGUS (Ribavirin) With or Without Pioglitazone in Treatment-Naive Patients With Chronic Hepatitis C and Insulin Resistance. Completed NCT00545233 Phase 4 peginterferon alfa-2a [Pegasys];ribavirin [Copegus];Pioglitazone
35 A Study of the Impact of an Early Biopsy in Patients Treated With CellCept (Mycophenolate Mofetil) After Kidney Transplantation Completed NCT00817687 Phase 4 mycophenolate mofetil [CellCept];mycophenolate mofetil [CellCept]
36 A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate Completed NCT01000610 Phase 4 rituximab [MabThera/Rituxan];methotrexate;methylprednisolone
37 A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Methotrexate Completed NCT00934648 Phase 4 rituximab [MabThera/Rituxan];methotrexate
38 A Clinical Study to Evaluate if Benzalkonium Chloride (BAK) in a Quinolone Eyedrop Reduces the Likelihood of Developing Resistant Organisms Completed NCT00874887 Phase 4 moxifloxacin 0.5% HCI ophthalmic solution;gatifloxacin ophthalmic solution 0.3%
39 Fecal Recovery of the Probiotic Bacteria Lactobacillus Rhamnosus GG (LGG) and Bifidobacterium Animalis Subspecies Lactis BB-12 (BB-12) in Healthy Humans Following Daily Consumption of a Probiotic Supplement Completed NCT01757054 Phase 4
40 A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis. Completed NCT00502853 Phase 4 rituximab [MabThera/Rituxan];Methotrexate
41 Topical Psoriasis Study for Patients Receiving Biologic Therapy Completed NCT02983981 Phase 4 Topicort Topical Spray
42 ADIponectin and Asymmetric Dimethylarginine (ADMA) Level in Type-2 Diabetes Patients After 12 Weeks of Treatment With GlimepiRide And Metformin Fixed Dose Combination Completed NCT01204580 Phase 4 GLIMEPIRIDE + METFORMIN
43 Clinical Trial on the Effects of Long Term Administration of 20% Albumin in the Cardiovascular and Renal Function, And Hepatic Hemodynamics in Advanced Patients With Cirrhosis and Ascites. Completed NCT00968695 Phase 4 Albumin
44 Pilot Study of the Rotavirus Vaccine in Infants With Intestinal Failure Completed NCT00995813 Phase 4
45 A Study of Safety and Effectiveness of Ultracet in Patients With Chronic Cancer Pain Completed NCT01968018 Phase 4 Tramadol HCI/acetaminophen
46 A Single Research Site Bile Acid Sequestrant Acceptability (BASA) Scale Pilot Validation Study Completed NCT01062269 Phase 4 Cholestyramine;Cholestyramine;Tang
47 Comparison of Colesevelam Hydrogen Chloride (HCl) Powder For Oral Suspension Versus Generic Cholestyramine Through Use of the Bile Acid Sequestrant Acceptability (BASA) Scale Completed NCT01122108 Phase 4 Cholestyramine;Colesevelam HCl
48 An Efficacy Study of Chlorhexidine Mouthwashes Completed NCT01751178 Phase 4 Chlorhexidine Digluconate Mouthwash with Alcohol;Chlorhexidine Digluconate Mouthwash without Alcohol
49 A Demonstration Project to Add Pre- or Post-exposure Prophylaxis to Combination HIV Prevention Services Completed NCT01781806 Phase 4 emtricitabine 200mg/tenofovir 300mg
50 The Use of 18F-ALF-NOTA-PRGD2 PET/CT Scan to Predict the Efficacy and Adverse Events of Apatinib in Malignancies. Completed NCT03384511 Phase 4 Apatinib

Search NIH Clinical Center for Scoliosis, Isolated 1

Genetic Tests for Scoliosis, Isolated 1

Anatomical Context for Scoliosis, Isolated 1

MalaCards organs/tissues related to Scoliosis, Isolated 1:

42
Bone, Brain, T Cells, Testes, Kidney, Eye, B Cells

Publications for Scoliosis, Isolated 1

Articles related to Scoliosis, Isolated 1:

(show top 50) (show all 2356)
# Title Authors Year
1
Extent of Depression in Juvenile and Adolescent Idiopathic Scoliosis Patients during Treatment with Braces. ( 30703588 )
2019
2
Clinical Relevance of Preoperative MRI in Adolescent Idiopathic Scoliosis: Is Hydromyelia a Predictive Factor of Intraoperative Electrophysiological Monitoring Alterations? ( 30913042 )
2019
3
Genetic polymorphisms of PAX1 are functionally associated with different PUMC types of adolescent idiopathic scoliosis in a northern Chinese Han population. ( 30572100 )
2019
4
Biomechanical Comparison of the Load-Sharing Capacity of High and Low Implant Density Constructs With Three Types of Pedicle Screws for the Instrumentation of Adolescent Idiopathic Scoliosis. ( 30587316 )
2019
5
Incidence of Intraspinal and Extraspinal MRI Abnormalities in Patients With Adolescent Idiopathic Scoliosis. ( 30587320 )
2019
6
The Link Between the 3D Spino-pelvic Alignment and Vertebral Body morphology in Adolescent Idiopathic Scoliosis. ( 30587321 )
2019
7
The 3D Sagittal Profile of Thoracic Versus Lumbar Major Curves in Adolescent Idiopathic Scoliosis. ( 30587322 )
2019
8
Patients' Perceptions of Breast Asymmetry Improve After Spinal Fusion for Adolescent Idiopathic Scoliosis. ( 30587325 )
2019
9
Surgery for the Adolescent Idiopathic Scoliosis Patients After Skeletal Maturity: Early Versus Late Surgery. ( 30587326 )
2019
10
Major Complications at Two Years After Surgery Impact SRS Scores for Adolescent Idiopathic Scoliosis Patients. ( 30587327 )
2019
11
The effect of orthotic interventions on balance performance in adolescent idiopathic scoliosis: A systematic literature review. ( 30601092 )
2019
12
Three-Dimensional Computed Tomography Analysis of Spinal Canal Length Increase After Surgery for Adolescent Idiopathic Scoliosis: A Multicenter Study. ( 30601415 )
2019
13
Predictive factors for brace treatment outcome in adolescent idiopathic scoliosis: a best-evidence synthesis. ( 30607519 )
2019
14
Back Pain and Outcomes of Pregnancy After Instrumented Spinal Fusion for Adolescent Idiopathic Scoliosis. ( 30610987 )
2019
15
Is rasterstereography a valid noninvasive method for the screening of juvenile and adolescent idiopathic scoliosis? ( 30617835 )
2019
16
Acute muscle stretching and the ability to maintain posture in females with adolescent idiopathic scoliosis. ( 30636726 )
2019
17
A stability-based model of a growing spine with adolescent idiopathic scoliosis: A combination of musculoskeletal and finite element approaches. ( 30638786 )
2019
18
The Reliability of Intraoperative Crossbar Technique in Determining the Upper Instrumented Vertebra (UIV) Tilt Angle for Adolescent Idiopathic Scoliosis (AIS) Undergoing Posterior Spinal Fusion. ( 30640749 )
2019
19
Cervical spine alignment following surgery for adolescent idiopathic scoliosis (AIS): a pre-to-post analysis of 81 patients. ( 30646880 )
2019
20
Rare variant of HSPG2 is not involved in the development of adolescent idiopathic scoliosis: evidence from a large-scale replication study. ( 30646882 )
2019
21
Global Sagittal Alignment and Proximal Junctional Kyphosis in Adolescent Idiopathic Scoliosis. ( 30660217 )
2019
22
Spine and Lower Extremity Kinematics Exhibited During Running by Adolescent Idiopathic Scoliosis Patients With Spinal Fusion. ( 30660219 )
2019
23
Accuracy of photogrammetry for detecting adolescent idiopathic scoliosis progression. ( 30661515 )
2019
24
Quantitative analysis of local bone graft harvested from the posterior elements during posterior spinal fusion in Adolescent Idiopathic Scoliosis patients. ( 30662243 )
2019
25
Surgical Outcomes of Anterior Versus Posterior Fusion in Lenke Type 1 Adolescent Idiopathic Scoliosis. ( 30664096 )
2019
26
Differential rod contouring on thoracolumbar/lumbar curvature in patients with adolescent idiopathic scoliosis: An analysis with intraoperative acquisition of three-dimensional imaging. ( 30683452 )
2019
27
Postoperative lumbar curve progression makes shoulder imbalance deteriorated in Lenke type 2B/C adolescent idiopathic scoliosis patients underwent selective thoracic fusion. ( 30684704 )
2019
28
Anterior spinal overgrowth of the thoracic spine may not be involved in the initiation of adolescent idiopathic scoliosis. ( 30685373 )
2019
29
Incidence and risk factors for proximal junctional kyphosis in adolescent idiopathic scoliosis after correction surgery: a meta-analysis. ( 30690145 )
2019
30
Manual therapy treatment for adolescent idiopathic scoliosis. ( 30691751 )
2019
31
Anatomical reference marks, evaluation parameters and reproducibility of surface topography for evaluating the adolescent idiopathic scoliosis: a systematic review with meta-analysis. ( 30708093 )
2019
32
A prospective analysis of motion and deformity at the shoulder level in surgically treated adolescent idiopathic scoliosis. ( 30721841 )
2019
33
Non-ionizing method of screening adolescent idiopathic scoliosis in schoolchildren. ( 30726384 )
2019
34
Long-term follow-up after surgical treatment of adolescent idiopathic scoliosis using high-density pedicle screw constructs: Is 5-year routine visit required? ( 30741338 )
2019
35
Etiology of Adolescent Idiopathic Scoliosis: A Literature Review. ( 30744305 )
2019
36
Association between lay perception of morbidity and appropriateness of specialized health care use in Adolescent Idiopathic Scoliosis. ( 30756421 )
2019
37
Could the clinical effectiveness be improved under the integration of orthotic intervention and scoliosis specific exercise in managing adolescent idiopathic scoliosis? -A randomized controlled trial study. ( 30768449 )
2019
38
Increased acute postoperative wound problems following spinal fusion in overweight patients with adolescent idiopathic scoliosis. ( 30768579 )
2019
39
COMPARISON OF IMPLANT DENSITY IN THE MANAGEMENT OF LENKE 1B AND 1C ADOLESCENT IDIOPATHIC SCOLIOSIS. ( 30774527 )
2019
40
ROTATION ASSESSMENT IN ADOLESCENT IDIOPATHIC SCOLIOSIS WITH ROD DEROTATION. ( 30774529 )
2019
41
Can posterior implant removal prevent device-related vertebral osteopenia after posterior fusion in adolescent idiopathic scoliosis? A mean 29-year follow-up study. ( 30783802 )
2019
42
A multiethnic meta-analysis defined the association of rs12946942 with severe adolescent idiopathic scoliosis. ( 30787423 )
2019
43
Management of Adolescent Idiopathic Scoliosis: Institutional Experience, Integration into Neurosurgical Practice, and Impact on Resident Training. ( 30797921 )
2019
44
Progressive decline in pulmonary function 5 years post-operatively in patients who underwent anterior instrumentation for surgical correction of adolescent idiopathic scoliosis. ( 30798454 )
2019
45
The Sagittal Thoracic Modifier Component of the Lenke Classification System in Moderate and Severe Adolescent Idiopathic Scoliosis: Reliability and Reproducibility of Measurements Among 5 Observers. ( 30807366 )
2019
46
Health-Related Quality of Life and Postural Changes of Spinal Alignment in Female Adolescents Associated with Back Pain in Adolescent Idiopathic Scoliosis - A Prospective Cross-Sectional Study. ( 30817729 )
2019
47
Editor's Spotlight/Take 5: How Common Is Back Pain and What Biopsychosocial Factors Are Associated With Back Pain in Patients With Adolescent Idiopathic Scoliosis? ( 30844831 )
2019
48
Adolescent idiopathic scoliosis associated POC5 mutation impairs cell cycle, cilia length and centrosome protein interactions. ( 30845169 )
2019
49
Predicting lowest hemoglobin level and risk of blood transfusion in spinal fusion surgery for adolescent idiopathic scoliosis. ( 30848365 )
2019
50
Customized k-nearest neighbourhood analysis in the management of adolescent idiopathic scoliosis using 3D markerless asymmetry analysis. ( 30849240 )
2019

Variations for Scoliosis, Isolated 1

ClinVar genetic disease variations for Scoliosis, Isolated 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MAPK7 NM_002749.3(MAPK7): c.886G> A (p.Ala296Thr) single nucleotide variant Pathogenic rs147296805 GRCh37 Chromosome 17, 19284408: 19284408
2 MAPK7 NM_002749.3(MAPK7): c.886G> A (p.Ala296Thr) single nucleotide variant Pathogenic rs147296805 GRCh38 Chromosome 17, 19381095: 19381095
3 MAPK7 NM_002749.3(MAPK7): c.1760C> T (p.Pro587Leu) single nucleotide variant Pathogenic rs758163506 GRCh37 Chromosome 17, 19285376: 19285376
4 MAPK7 NM_002749.3(MAPK7): c.1760C> T (p.Pro587Leu) single nucleotide variant Pathogenic rs758163506 GRCh38 Chromosome 17, 19382063: 19382063
5 MAPK7 NM_002749.3(MAPK7): c.1943C> T (p.Pro648Leu) single nucleotide variant Pathogenic rs1555613564 GRCh37 Chromosome 17, 19285559: 19285559
6 MAPK7 NM_002749.3(MAPK7): c.1943C> T (p.Pro648Leu) single nucleotide variant Pathogenic rs1555613564 GRCh38 Chromosome 17, 19382246: 19382246

Expression for Scoliosis, Isolated 1

Search GEO for disease gene expression data for Scoliosis, Isolated 1.

Pathways for Scoliosis, Isolated 1

GO Terms for Scoliosis, Isolated 1

Sources for Scoliosis, Isolated 1

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