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MCID: SCR039
MIFTS: 42

Scorpion Envenomation

Categories: Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Scorpion Envenomation

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MalaCards integrated aliases for Scorpion Envenomation:

Name: Scorpion Envenomation 58

Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Scorpion Envenomation

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MalaCards based summary : Scorpion Envenomation is related to cardiogenic shock and myocarditis. An important gene associated with Scorpion Envenomation is CCL5 (C-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and TNFR1 Pathway. The drugs Prazosin and Adrenergic Antagonists have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and eye, and related phenotypes are erythema and tachycardia

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Related Diseases for Scorpion Envenomation

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Diseases related to Scorpion Envenomation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 474)
# Related Disease Score Top Affiliating Genes
1 cardiogenic shock 30.8 TNF IL6
2 myocarditis 30.5 TNF IL6
3 disseminated intravascular coagulation 30.1 TNF IL6
4 aspiration pneumonia 29.9 TNF IL6
5 acute pancreatitis 29.7 TNF IL6
6 respiratory failure 29.5 TNF IL6 CCL5
7 myocardial infarction 29.3 TNF IL6 CCL5
8 pulmonary edema 10.8
9 ocular motor apraxia 10.5
10 paresthesia 10.3
11 atrial standstill 1 10.2
12 hyperglycemia 10.2
13 toxic myocarditis 10.2
14 metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 10.2
15 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.2
16 priapism 10.2
17 hypertensive encephalopathy 10.2
18 broken heart syndrome 10.2
19 encephalopathy 10.2
20 tremor 10.2
21 near-fatal asthma 10.1 TNF CCL5
22 spotted fever 10.1 TNF CCL5
23 spotted fever rickettsiosis 10.1 TNF CCL5
24 orofacial granulomatosis 10.1 TNF CCL5
25 helicobacter pylori infection 10.1 TNF CCL5
26 epidemic typhus 10.0 TNF CCL5
27 pulmonary sarcoidosis 10.0 TNF CCL5
28 dengue disease 10.0 TNF CCL5
29 japanese encephalitis 10.0 TNF CCL5
30 acroosteolysis 10.0
31 ataxia and polyneuropathy, adult-onset 10.0
32 disease by infectious agent 10.0
33 metabolic acidosis 10.0
34 cardiac arrest 10.0
35 mitral valve insufficiency 10.0
36 coronary artery vasospasm 10.0
37 hemolytic-uremic syndrome 10.0
38 dilated cardiomyopathy 10.0
39 diarrhea 10.0
40 angioedema 10.0
41 thrombocytosis 10.0
42 acute kidney failure 10.0
43 ischemia 10.0
44 lactic acidosis 10.0
45 plexopathy 10.0
46 acute myocarditis 10.0
47 liver disease 10.0
48 hypokalemia 10.0
49 brain edema 10.0
50 pancreatitis 10.0

Graphical network of the top 20 diseases related to Scorpion Envenomation:



Diseases related to Scorpion Envenomation
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Symptoms & Phenotypes for Scorpion Envenomation

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Human phenotypes related to Scorpion Envenomation:

58 31 (show top 50) (show all 60)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 erythema 58 31 hallmark (90%) Very frequent (99-80%) HP:0010783
2 tachycardia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001649
3 vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002013
4 abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002027
5 paresthesia 58 31 frequent (33%) Frequent (79-30%) HP:0003401
6 restlessness 58 31 frequent (33%) Frequent (79-30%) HP:0000711
7 miosis 58 31 frequent (33%) Frequent (79-30%) HP:0000616
8 hyperhidrosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000975
9 tremor 58 31 occasional (7.5%) Occasional (29-5%) HP:0001337
10 hypertension 58 31 occasional (7.5%) Occasional (29-5%) HP:0000822
11 hypokalemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002900
12 congestive heart failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0001635
13 purpura 58 31 occasional (7.5%) Occasional (29-5%) HP:0000979
14 tachypnea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002789
15 diarrhea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002014
16 excessive salivation 58 31 occasional (7.5%) Occasional (29-5%) HP:0003781
17 mydriasis 58 31 occasional (7.5%) Occasional (29-5%) HP:0011499
18 hyperglycemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0003074
19 glycosuria 58 31 occasional (7.5%) Occasional (29-5%) HP:0003076
20 pulmonary edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0100598
21 increased nt-probnp level 58 31 occasional (7.5%) Occasional (29-5%) HP:0031185
22 increased troponin i level in blood 58 31 occasional (7.5%) Occasional (29-5%) HP:0410173
23 acute pancreatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001735
24 chills 58 31 occasional (7.5%) Occasional (29-5%) HP:0025143
25 t-wave inversion 58 31 occasional (7.5%) Occasional (29-5%) HP:0010872
26 cardiogenic shock 58 31 occasional (7.5%) Occasional (29-5%) HP:0030149
27 respiratory alkalosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001950
28 abnormal nasal mucus secretion 58 31 occasional (7.5%) Occasional (29-5%) HP:0031416
29 st segment depression 58 31 occasional (7.5%) Occasional (29-5%) HP:0012250
30 prominent u wave 58 31 occasional (7.5%) Occasional (29-5%) HP:0025072
31 elevated serum aspartate aminotransferase 58 31 occasional (7.5%) Occasional (29-5%) HP:0031956
32 increased circulating creatine kinase mb isoform 58 31 occasional (7.5%) Occasional (29-5%) HP:0032232
33 mixed respiratory and metabolic acidosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0005967
34 priapism 58 31 occasional (7.5%) Occasional (29-5%) HP:0200023
35 increased lactate dehydrogenase level 31 occasional (7.5%) HP:0025435
36 hyperreflexia 58 31 very rare (1%) Very rare (<4-1%) HP:0001347
37 ataxia 58 31 very rare (1%) Very rare (<4-1%) HP:0001251
38 dysarthria 58 31 very rare (1%) Very rare (<4-1%) HP:0001260
39 dyskinesia 58 31 very rare (1%) Very rare (<4-1%) HP:0100660
40 fever 58 31 very rare (1%) Very rare (<4-1%) HP:0001945
41 bundle branch block 58 31 very rare (1%) Very rare (<4-1%) HP:0011710
42 stroke 58 31 very rare (1%) Very rare (<4-1%) HP:0001297
43 myocarditis 58 31 very rare (1%) Very rare (<4-1%) HP:0012819
44 ketonuria 58 31 very rare (1%) Very rare (<4-1%) HP:0002919
45 acute kidney injury 58 31 very rare (1%) Very rare (<4-1%) HP:0001919
46 ventricular extrasystoles 58 31 very rare (1%) Very rare (<4-1%) HP:0006682
47 blurred vision 58 31 very rare (1%) Very rare (<4-1%) HP:0000622
48 hyperkinetic movements 58 31 very rare (1%) Very rare (<4-1%) HP:0002487
49 rhabdomyolysis 58 31 very rare (1%) Very rare (<4-1%) HP:0003201
50 abnormal involuntary eye movements 58 31 very rare (1%) Very rare (<4-1%) HP:0012547
Sources

Drugs & Therapeutics for Scorpion Envenomation

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Drugs for Scorpion Envenomation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prazosin Approved Phase 3 19216-56-9 4893
2 Adrenergic Antagonists Phase 3
3 Adrenergic alpha-1 Receptor Antagonists Phase 3
4 Neurotransmitter Agents Phase 3
5 Adrenergic alpha-Antagonists Phase 3
6 Adrenergic Agents Phase 3
7 Antihypertensive Agents Phase 3
8 Antivenins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparative Study of Efficacy of Antiscorpion Venom Serum(AScVS)vs Prazosin in the Management of Severe Scorpion(Mesobuthus Tamulus Concanesis Pocock)Envenomation and Evaluation of Effects of the Combination of AScVS + Prazosin Therapy. Completed NCT00753064 Phase 3 Antiscorpion venom serum(AScVS).;T.Prazosin;AScVS + Prazosin
2 Establishment of Natural History of Scorpion Envenomation in the Absence of Antivenom Treatment in Pediatric Patients Completed NCT00696683

Search NIH Clinical Center for Scorpion Envenomation

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Genetic Tests for Scorpion Envenomation

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Anatomical Context for Scorpion Envenomation

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MalaCards organs/tissues related to Scorpion Envenomation:

40
Bone, Heart, Eye, Kidney, Lung, Spinal Cord, Liver
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Publications for Scorpion Envenomation

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Articles related to Scorpion Envenomation:

(show top 50) (show all 387)
# Title Authors PMID Year
1
Clinical Features and Prognosis of Severe Scorpion Envenomation in Children. 61
33682212 2021
2
Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation. 61
33116136 2020
3
Echocardiographic Evaluation of the Response to Prazosin Treatment in Scorpion Sting. 61
33005956 2020
4
Tityus stigmurus venom causes genetic damage in blood and testicular cells and affects the number and morphology of gametogenic lineage cells in mice. 61
32659238 2020
5
Neurotoxicity of Tityus bahiensis (brown scorpion) venom in sympathetic vas deferens preparations and neuronal cells. 61
32548756 2020
6
Effect of Tityus serrulatus scorpion venom on isolated jejunum: A very useful tool to study the interaction between neurons in the enteric nervous system. 61
32464449 2020
7
Echocardiography versus cardiac biomarkers for myocardial dysfunction in children with scorpion envenomation: An observational study from tertiary care center in northern India. 61
33189207 2020
8
Complete neutralization of the lethality of Hemiscorpius lepturus crude venom by a novel anti-recombinant phospholipase D1 IgGs. 61
32445840 2020
9
A Relationship Between Clinical and Laboratory Characteristics in Children With Severe Scorpion Envenomation in Çukurova, Turkey. 61
29698349 2020
10
Dobutamine in the treatment of severe scorpion envenoming. 61
32428515 2020
11
Epidemiological Characteristics of Scorpionism in West Azerbaijan Province, Northwest of Iran. 61
33365347 2020
12
Involvement of the Endothelin Receptor Type A in the Cardiovascular Inflammatory Response Following Scorpion Envenomation. 61
32545475 2020
13
Review of Scorpion Stings and Snakebites Treated by the French Military Health Service During Overseas Operations Between 2015 and 2017. 61
32331950 2020
14
Uncommon presentation of scorpion sting at teaching hospital. 61
32754547 2020
15
Novel Mutant Phospholipase D from Hemiscorpius lepturus Acts as A Highly Immunogen in BALB/c Mice Against the Lethality of Scorpion Venom. 61
32260428 2020
16
Scorpion stings in pregnancy: an analysis of outcomes in 66 envenomed pregnant patients in Iran. 61
32405289 2020
17
Interleukin-1 Receptor-Induced Nitric Oxide Production in the Pancreas Controls Hyperglycemia Caused by Scorpion Envenomation. 61
32150895 2020
18
Scorpion envenomation: state of the art. 61
32125457 2020
19
Is there any relationship between initial hematological parameters and severity of scorpion envenomation? 61
32558413 2020
20
Demographic and epidemiological characteristics of scorpion envenomation and daily forecasting of scorpion sting counts in Touggourt, Algeria. 61
32660217 2020
21
Fatal scorpion envenomation in a 3-month-old infant. 61
31885003 2019
22
Black Scorpion (Tityus obscurus) Fatalities in Guyana and a Literature Review. 61
31564443 2019
23
Predictors for Mortality in Children with Scorpion Envenomation Admitted to Pediatric Intensive Care Unit, Qena Governorate, Egypt. 61
31407657 2019
24
Evaluation of Scorpion Envenomation by Tityus trivittatus in Adults: An Analysis of Variables Related to Severity of Clinical Presentation. 61
31351826 2019
25
Scorpion envenomation and inflammation: Beyond neurotoxic effects. 61
31228480 2019
26
Comparing clinical outcomes between two scorpion antivenom dosing strategies in children. 61
30729820 2019
27
Venoms of Iranian Scorpions (Arachnida, Scorpiones) and Their Potential for Drug Discovery. 61
31340554 2019
28
Protective effect of aqueous extract, fractions and phenolic compounds of Hancornia speciosa fruits on the inflammatory damage in the lungs of mice induced by Tityus serrulatus envenomation. 61
30902683 2019
29
Cerebrospinal inflammatory response following scorpion envenomation: role of histamine H1 and H3 receptors. 61
30604198 2019
30
Scorpion Envenomation to Therapeutics. 61
31064904 2019
31
The epidemiology and severity of scorpion envenoming in South Africa as managed by the Tygerberg Poisons Information Centre over a 10 year period. 61
30873347 2019
32
A randomized comparative study between intravenous and intramuscular scorpion antivenom regimens in children. 61
30664882 2019
33
Study of Factors Contributing to Scorpion Envenomation in Arizona. 61
30488297 2019
34
Toxicological and epidemiological studies of scorpion sting cases and morphological characterization of scorpions (Leiurusquin questriatus and Androctonus crassicauda) in Luxor, Egypt. 61
31049294 2019
35
Mechanisms of toxic cardiomyopathy. 61
30260248 2019
36
Evaluation of oxidant/antioxidant status in serum of sheep experimentally envenomated with Hemiscorpius lepturus scorpion venom. 61
31338151 2019
37
[Epidemiology of home accidents in childhood: experience in the Division of General Pediatrics in Southern Tunisia]. 61
31489086 2019
38
Fatal scorpion envenomation: a case report. 61
31268278 2019
39
EP80317 Restrains Inflammation and Mortality Caused by Scorpion Envenomation in Mice. 61
30886580 2019
40
Scorpion envenomation: from a neglected to a helpful disease? 61
29846746 2019
41
Severe Troponin I Elevation and Myocardial Dysfunction in a Child with Scorpion Sting. 61
31073500 2018
42
Myocarditis and Early Markers of Cardiac Response Associated with Scorpion Stings in Children. 61
30257800 2018
43
Myocardial injury induced by scorpion sting envenoming and evidence of oxidative stress in Egyptian children. 61
30171930 2018
44
Determination of median effective dose (ED50) of scorpion antivenom against scorpion envenomation using a newly developed formula. 61
30891569 2018
45
Efficacy of Scorpion Antivenom in Grade III and IV Scorpion Envenomation. 61
29704171 2018
46
Incidence, mechanisms and impact outcome of hyperglycaemia in severe scorpion-envenomed patients. 61
29977498 2018
47
Value of troponin levels in the diagnosis of cardiac dysfunction in moderate scorpion envenomation. 61
28776390 2018
48
Involvement of Alveolar Macrophages and Neutrophils in Acute Lung Injury After Scorpion Envenomation: New Pharmacological Targets. 61
29492721 2018
49
Management of scorpion envenomation at the Faya-Largeau medical post, February-June, 2014. 61
29799424 2018
50
Inverted Takotsubo syndrome in Androctonus australis scorpion envenomation. 61
28905655 2018
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Variations for Scorpion Envenomation

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Expression for Scorpion Envenomation

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Search GEO for disease gene expression data for Scorpion Envenomation.
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Pathways for Scorpion Envenomation

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Pathways related to Scorpion Envenomation according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.84 TNF IL6 CCL5
2
TNFR1 Pathway 63
Show member pathways
 12.72 TNF IL6 CCL5
3
Human cytomegalovirus infection 36
Show member pathways
 12.59 TNF IL6 CCL5
4
Prion disease 36
Show member pathways
 12.47 TNF IL6 CCL5
5
Measles 36
Show member pathways
 12.45 TNF IL6 CCL5
6
Herpes simplex virus 1 infection 36
12.43 TNF IL6 CCL5
7
Selenium Micronutrient Network 1
Show member pathways
 11.91 TNF IL6 CCL5
8
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 11.88 TNF IL6 CCL5
9
Spinal Cord Injury 1
11.76 TNF IL6
10
NOD-like receptor signaling pathway 36
11.76 TNF IL6 CCL5
11
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.74 TNF IL6
12
Interleukin-4 and 13 signaling 65
11.73 TNF IL6
13
Insulin resistance 36
Show member pathways
 11.71 TNF IL6
14
Amoebiasis 36
11.67 TNF IL6
15
AGE-RAGE signaling pathway in diabetic complications 36
11.65 TNF IL6
16
Hematopoietic cell lineage 36
11.65 TNF IL6
17
Th1 Differentiation Pathway 64
Show member pathways
 11.53 TNF IL6
18
Pertussis 36
11.52 TNF IL6
19
Dendritic Cells Developmental Lineage Pathway 64
11.51 TNF IL6
20
TNF signaling pathway 36
11.48 TNF IL6 CCL5
21
IgA-Producing B Cells in the Intestine 64
11.45 TNF IL6
22
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.43 TNF IL6
23
Legionellosis 36
11.38 TNF IL6
24
Photodynamic therapy-induced AP-1 survival signaling. 1
11.32 TNF IL6
25
Malaria 36
11.3 TNF IL6
26
Rheumatoid arthritis 36
11.3 TNF IL6 CCL5
27
amb2 Integrin signaling 1
11.28 TNF IL6
28
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.24 TNF IL6
29
African trypanosomiasis 36
11.12 TNF IL6
30
IL-10 Pathway 63
11.08 TNF IL6
31
Development and heterogeneity of the ILC family 1
11.03 TNF IL6
32
Antifolate resistance 36
11 TNF IL6
33
Cytokines and Inflammatory Response 1
10.96 TNF IL6
34
Lung fibrosis 1
10.93 TNF IL6 CCL5
35
EBV LMP1 signaling 1
10.86 TNF CCL5
36
Transcription factor regulation in adipogenesis 1
10.8 TNF IL6
37
Overview of nanoparticle effects 1
10.71 TNF IL6
38
G-protein signaling_Rap2B regulation pathway 23
10.67 TNF IL6 CCL5
39
Interleukin-10 signaling 65
10.49 TNF IL6 CCL5
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GO Terms for Scorpion Envenomation

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Biological processes related to Scorpion Envenomation according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.74 TNF IL6 CCL5
2 inflammatory response GO:0006954 9.7 TNF IL6 CCL5
3 response to virus GO:0009615 9.66 TNF CCL5
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.65 TNF IL6
5 defense response to Gram-positive bacterium GO:0050830 9.65 TNF IL6
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.65 TNF CCL5
7 cytokine-mediated signaling pathway GO:0019221 9.65 TNF IL6 CCL5
8 positive regulation of interleukin-6 production GO:0032755 9.64 TNF IL6
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.64 TNF IL6
10 cellular response to organic cyclic compound GO:0071407 9.63 TNF CCL5
11 response to glucocorticoid GO:0051384 9.63 TNF IL6
12 positive regulation of T cell proliferation GO:0042102 9.62 IL6 CCL5
13 positive regulation of interleukin-8 production GO:0032757 9.62 TNF IL6
14 humoral immune response GO:0006959 9.61 TNF IL6
15 positive regulation of interleukin-1 beta production GO:0032731 9.61 TNF IL6
16 positive regulation of cell adhesion GO:0045785 9.6 TNF CCL5
17 negative regulation of fat cell differentiation GO:0045599 9.59 TNF IL6
18 monocyte chemotaxis GO:0002548 9.58 IL6 CCL5
19 negative regulation of viral genome replication GO:0045071 9.58 TNF CCL5
20 protein kinase B signaling GO:0043491 9.56 TNF CCL5
21 positive regulation of chemokine production GO:0032722 9.55 TNF IL6
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.54 TNF CCL5
23 negative regulation of neurogenesis GO:0050768 9.51 TNF IL6
24 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.49 TNF IL6
25 positive regulation of glial cell proliferation GO:0060252 9.46 TNF IL6
26 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.43 TNF IL6
27 regulation of insulin secretion GO:0050796 9.43 TNF IL6 CCL5
28 positive regulation of neuroinflammatory response GO:0150078 9.4 TNF IL6
29 negative regulation of lipid storage GO:0010888 9.37 TNF IL6
30 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.33 TNF IL6 CCL5
31 vascular endothelial growth factor production GO:0010573 9.32 TNF IL6
32 positive regulation of smooth muscle cell proliferation GO:0048661 9.13 TNF IL6 CCL5
33 positive regulation of JAK-STAT cascade GO:0046427 8.8 TNF IL6 CCL5

Molecular functions related to Scorpion Envenomation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 TNF IL6 CCL5
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Sources for Scorpion Envenomation

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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