MCID: SCR039
MIFTS: 38

Scorpion Envenomation

Categories: Rare diseases

Aliases & Classifications for Scorpion Envenomation

MalaCards integrated aliases for Scorpion Envenomation:

Name: Scorpion Envenomation 59

Classifications:



External Ids:

Orphanet 59 ORPHA466677
ICD10 via Orphanet 34 T63.2

Summaries for Scorpion Envenomation

MalaCards based summary : Scorpion Envenomation is related to cardiogenic shock and myocardial infarction. An important gene associated with Scorpion Envenomation is IL6 (Interleukin 6), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Prazosin and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and liver.

Related Diseases for Scorpion Envenomation

Diseases related to Scorpion Envenomation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 cardiogenic shock 30.4 IL6 TNF
2 myocardial infarction 29.7 CCL5 IL6 TNF
3 pulmonary edema 10.3
4 atherosclerosis susceptibility 10.1 IL6 TNF
5 behcet syndrome 10.1 IL6 TNF
6 maturity-onset diabetes of the young, type 1 10.1 IL6 TNF
7 psoriatic arthritis 10.1 IL6 TNF
8 kawasaki disease 10.1 IL6 TNF
9 common variable immunodeficiency 10.1 IL6 TNF
10 osteoarthritis 10.1 IL6 TNF
11 ulcerative colitis 10.1 IL6 TNF
12 acquired metabolic disease 10.1 IL6 TNF
13 bone disease 10.1 IL6 TNF
14 nonalcoholic fatty liver disease 10.1 IL6 TNF
15 pertussis 10.1 IL6 TNF
16 chagas disease 10.1 IL6 TNF
17 urinary system disease 10.1 IL6 TNF
18 synovitis 10.1 IL6 TNF
19 immune system disease 10.1 IL6 TNF
20 gastrointestinal system cancer 10.1 IL6 TNF
21 central nervous system disease 10.1 IL6 TNF
22 periodontal disease 10.1 IL6 TNF
23 mouth disease 10.1 IL6 TNF
24 peripheral nervous system disease 10.1 IL6 TNF
25 acquired immunodeficiency syndrome 10.1 IL6 TNF
26 intestinal disease 10.1 IL6 TNF
27 cerebrovascular disease 10.1 IL6 TNF
28 gastrointestinal system disease 10.1 IL6 TNF
29 myocarditis 10.1 IL6 TNF
30 nervous system disease 10.1 IL6 TNF
31 leishmaniasis 10.1 IL6 TNF
32 fatty liver disease 10.1 IL6 TNF
33 leukomalacia 10.1 IL6 TNF
34 angioimmunoblastic lymphadenopathy with dysproteinemia 10.1 IL6 TNF
35 critical limb ischemia 10.1 IL6 TNF
36 limb ischemia 10.1 IL6 TNF
37 streptococcal toxic-shock syndrome 10.1 IL6 TNF
38 juvenile ankylosing spondylitis 10.1 IL6 TNF
39 spondylitis 10.1 IL6 TNF
40 null-cell leukemia 10.1 IL6 TNF
41 retinitis pigmentosa 55 10.1 IL6 TNF
42 anca-associated vasculitis 10.1 IL6 TNF
43 glossitis 10.1 IL6 TNF
44 laryngitis 10.1 IL6 TNF
45 anterior uveitis 10.1 IL6 TNF
46 acute vascular insufficiency of intestine 10.1 IL6 TNF
47 posterior urethral valves 10.1 IL6 TNF
48 osteosclerotic myeloma 10.1 IL6 TNF
49 poems syndrome 10.1 IL6 TNF
50 periapical periodontitis 10.1 IL6 TNF

Graphical network of the top 20 diseases related to Scorpion Envenomation:



Diseases related to Scorpion Envenomation

Symptoms & Phenotypes for Scorpion Envenomation

Drugs & Therapeutics for Scorpion Envenomation

Drugs for Scorpion Envenomation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prazosin Approved Phase 3 19216-56-9 4893
2
Midazolam Approved, Illicit Phase 2, Phase 3 59467-70-8 4192
3 Antivenins Phase 2, Phase 3,Phase 3
4 Immunologic Factors Phase 2, Phase 3,Phase 3
5 Antihypertensive Agents Phase 3
6 Adrenergic alpha-1 Receptor Antagonists Phase 3
7 Adrenergic alpha-Antagonists Phase 3
8 Neurotransmitter Agents Phase 3
9 Adrenergic Agents Phase 3
10 Adrenergic Antagonists Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial to Compare Two Anti-scorpion Serums Completed NCT00739440 Phase 4
2 A Trial of Equine F (ab')2 Antivenom for Treatment of Scorpion Envenomation in Morocco Completed NCT01336660 Phase 2, Phase 3
3 AScVS and/ or Prazosin for Scorpion Envenomation Completed NCT00753064 Phase 3 Antiscorpion venom serum(AScVS).;T.Prazosin;AScVS + Prazosin
4 Open Label Clinical Trial of Anascorp® in Pediatric Patients With Scorpion Sting Envenomation Completed NCT01599936 Phase 3
5 Open Label Study of Alacramyn® in Pediatric Patients With Scorpion Sting Envenomation Completed NCT01599923 Phase 3
6 Double-Blind, Alacramyn® vs. Placebo in Pediatric Patients Completed NCT00685230 Phase 2, Phase 3
7 Compare Two Anti-Scorpion Venom Serum In Children Completed NCT01415830 Phase 3
8 Treatment Protocol for Use of Anascorp™ in Patients With Scorpion Sting Envenomation Completed NCT00624078 Phase 2, Phase 3 Antivenin Centruroides (scorpion) F(ab)2 Anascorp™
9 Establishment of Natural History of Scorpion Envenomation Completed NCT00696683

Search NIH Clinical Center for Scorpion Envenomation

Genetic Tests for Scorpion Envenomation

Anatomical Context for Scorpion Envenomation

MalaCards organs/tissues related to Scorpion Envenomation:

41
Lung, Brain, Liver, Bone, Heart, Eye, Spinal Cord

Publications for Scorpion Envenomation

Articles related to Scorpion Envenomation:

(show top 50) (show all 161)
# Title Authors Year
1
Management of scorpion envenomation at the Faya-Largeau medical post, February-June, 2014. ( 29799424 )
2018
2
A Relationship Between Clinical and Laboratory Characteristics in Children With Severe Scorpion Envenomation in A8ukurova, Turkey. ( 29698349 )
2018
3
Update on the Epidemiology of Scorpion Envenomation in the South of Tunisia. ( 29338987 )
2018
4
Involvement of Alveolar Macrophages and Neutrophils in Acute Lung Injury After Scorpion Envenomation: New Pharmacological Targets. ( 29492721 )
2018
5
Efficacy of Scorpion Antivenom in Grade III and IV Scorpion Envenomation. ( 29704171 )
2018
6
Scorpion envenomation: from a neglected to a helpful disease? ( 29846746 )
2018
7
Value of troponin levels in the diagnosis of cardiac dysfunction in moderate scorpion envenomation. ( 28776390 )
2018
8
Study of Factors Contributing to Scorpion Envenomation in Arizona. ( 30488297 )
2018
9
Inverted Takotsubo syndrome in Androctonus australis scorpion envenomation. ( 28905655 )
2017
10
Epidemiological and clinical characteristics of scorpionism in Shiraz (2012-2016); development of a clinical severity grading for Iranian scorpion envenomation. ( 29445656 )
2017
11
Successful Use of Extracorporeal Membrane Oxygenation for the Treatment of Cardiogenic Shock due to Scorpion Envenomation. ( 28536661 )
2017
12
Severe scorpion envenomation: pathophysiology and the role of inflammation in multiple organ failure. ( 28655685 )
2017
13
Severe bark scorpion envenomation in adults(). ( 28753044 )
2017
14
Reactogenicity and safety assessment of an attenuated nanovaccine against scorpion envenomation: Preclinical study. ( 29061347 )
2017
15
A Stinging Suspicion Something Was Just Not Right: Methamphetamine Toxicity in Infant Mimics Scorpion Envenomation. ( 29095780 )
2017
16
Cost Minimization Analysis of Different Strategies of Management of Clinically Significant Scorpion Envenomation Among Pediatric Patients. ( 27749795 )
2016
17
Scorpion envenomation-induced acute thrombotic inferior myocardial infarction. ( 26875137 )
2016
18
The scorpion envenomation in the region of Faouar-KEBILI at 2010-2012 : study of 421 cases. ( 27532524 )
2016
19
Scorpion Envenomation in Pregnancy. ( 27255088 )
2016
20
EPIDEMIOLOGY OF SCORPION ENVENOMATION IN THE STATE OF CEARA8, NORTHEASTERN BRAZIL. ( 27007558 )
2016
21
Venom conjugated polylactide applied as biocompatible material for passive and active immunotherapy against scorpion envenomation. ( 26902547 )
2016
22
Clinical Presentation and Outcomes Associated with Different Treatment Modalities for Pediatric Bark Scorpion Envenomation. ( 27487782 )
2016
23
Scorpion envenomation cardiomyopathy: a promising model for takotsubo syndrome. ( 26135709 )
2015
24
Assessing and managing spider and scorpion envenomation. ( 26542925 )
2015
25
The first description of cardiac magnetic resonance findings in a severe scorpion envenomation: Is it a stress-induced (Takotsubo) cardiomyopathy like? ( 25601163 )
2015
26
Predictive Factors for Determining the Clinical Severity of Pediatric Scorpion Envenomation Cases in Southeastern Turkey. ( 26432426 )
2015
27
Voltage attenuation of the electrocardiogram QRS complexes in a patient with "scorpion envenomation"-induced Takotsubo syndrome. ( 25766301 )
2015
28
Epidemiological and Clinical Characteristics and Outcomes of Scorpion Envenomation in Hospitalized Children in Adiyaman, Turkey. ( 26199687 )
2015
29
Should dobutamine be used in severe scorpion envenomation. ( 26059736 )
2015
30
Managing scorpion envenomation in children. ( 25532976 )
2015
31
Doxazosin in the treatment of scorpion envenomation. ( 24696312 )
2015
32
Evolution of the electrocardiogram QRS complexes voltage in scorpion envenomation-induced Takotsubo syndrome. ( 25842284 )
2015
33
Scorpion envenomation. ( 25317885 )
2014
34
Scorpion envenomation. ( 25317886 )
2014
35
Scorpion envenomation. ( 25317887 )
2014
36
Scorpion envenomation. ( 25317888 )
2014
37
Sustained Ventricular Tachycardia and Cardiogenic Shock due to Scorpion Envenomation. ( 24715906 )
2014
38
Brainstem structures are primarily affected in an experimental model of severe scorpion envenomation. ( 24105889 )
2014
39
Effectiveness of anti scorpion venom for red scorpion envenomation. ( 24277969 )
2014
40
Cardiac involvement and its complications about three cases of severe scorpion envenomation. ( 24316266 )
2014
41
Immunomodulatory and protective properties of tacrolimus in experimental scorpion envenomation. ( 24674680 )
2014
42
Studying neglected diseases in children: antiserum for Indian red scorpion envenomation. ( 24713409 )
2014
43
Modulation of tissue inflammatory response by histamine receptors in scorpion envenomation pathogenesis: involvement of H4 receptor. ( 24858599 )
2014
44
Scorpion envenomation. ( 25075837 )
2014
45
Transpulmonary thermodilution for the assessment of hemodynamic patterns in patients with severe scorpion envenomation. ( 25160034 )
2014
46
You're the flight surgeon. Scorpion envenomation. ( 25197899 )
2014
47
Clinical comparison of scorpion envenomation by Androctonus mauritanicus and Buthus occitanus in children. ( 25218169 )
2014
48
Epidemiological review of scorpion envenomation in iran. ( 25276176 )
2014
49
Scorpion envenomation. ( 25317884 )
2014
50
An overview of platelet indices for evaluating platelet function in children with scorpion envenomation. ( 26417303 )
2014

Variations for Scorpion Envenomation

Expression for Scorpion Envenomation

Search GEO for disease gene expression data for Scorpion Envenomation.

Pathways for Scorpion Envenomation

Pathways related to Scorpion Envenomation according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 CCL5 IL6 TNF
2
Show member pathways
12.93 CCL5 IL6 TNF
3
Show member pathways
12.7 CCL5 IL6 TNF
4
Show member pathways
12.66 CCL5 IL6 TNF
5
Show member pathways
12.61 CCL5 IL6 TNF
6
Show member pathways
12.44 CCL5 IL6 TNF
7
Show member pathways
12.41 CCL5 IL6 TNF
8
Show member pathways
11.91 IL6 TNF
9 11.91 IL6 TNF
10
Show member pathways
11.91 CCL5 IL6 TNF
11 11.9 IL6 TNF
12 11.8 IL6 TNF
13
Show member pathways
11.79 IL6 TNF
14
Show member pathways
11.78 IL6 TNF
15 11.75 IL6 TNF
16 11.73 IL6 TNF
17 11.72 IL6 TNF
18
Show member pathways
11.7 IL6 TNF
19 11.65 IL6 TNF
20 11.64 IL6 TNF
21 11.63 IL6 TNF
22 11.54 CCL5 IL6 TNF
23 11.52 IL6 TNF
24 11.5 IL6 TNF
25
Show member pathways
11.42 IL6 TNF
26 11.39 CCL5 IL6 TNF
27 11.36 IL6 TNF
28 11.32 IL6 TNF
29 11.3 IL6 TNF
30 11.28 IL6 TNF
31 11.24 IL6 TNF
32 11.18 CCL5 IL6 TNF
33 11.1 IL6 TNF
34 11.09 IL6 TNF
35 11.08 CCL5 IL6
36 11.03 IL6 TNF
37 11 IL6 TNF
38 10.96 IL6 TNF
39 10.93 CCL5 IL6 TNF
40 10.86 CCL5 TNF
41 10.8 IL6 TNF
42 10.77 CCL5 IL6 TNF
43 10.71 IL6 TNF
44 10.67 CCL5 IL6 TNF
45 10.49 CCL5 IL6 TNF

GO Terms for Scorpion Envenomation

Biological processes related to Scorpion Envenomation according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.71 CCL5 IL6 TNF
2 cellular response to lipopolysaccharide GO:0071222 9.65 IL6 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.65 IL6 TNF
4 regulation of signaling receptor activity GO:0010469 9.65 CCL5 IL6 TNF
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.64 IL6 TNF
6 response to virus GO:0009615 9.64 CCL5 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.63 IL6 TNF
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.63 IL6 TNF
9 inflammatory response GO:0006954 9.63 CCL5 IL6 TNF
10 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.62 CCL5 TNF
11 cellular response to organic cyclic compound GO:0071407 9.62 CCL5 TNF
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 CCL5 IL6
13 regulation of insulin secretion GO:0050796 9.61 CCL5 TNF
14 response to glucocorticoid GO:0051384 9.6 IL6 TNF
15 positive regulation of T cell proliferation GO:0042102 9.59 CCL5 IL6
16 positive regulation of interleukin-6 production GO:0032755 9.58 IL6 TNF
17 humoral immune response GO:0006959 9.58 IL6 TNF
18 positive regulation of cell adhesion GO:0045785 9.57 CCL5 TNF
19 negative regulation of fat cell differentiation GO:0045599 9.56 IL6 TNF
20 monocyte chemotaxis GO:0002548 9.55 CCL5 IL6
21 negative regulation of viral genome replication GO:0045071 9.52 CCL5 TNF
22 protein kinase B signaling GO:0043491 9.51 CCL5 TNF
23 cytokine-mediated signaling pathway GO:0019221 9.5 CCL5 IL6 TNF
24 lipopolysaccharide-mediated signaling pathway GO:0031663 9.49 CCL5 TNF
25 positive regulation of JAK-STAT cascade GO:0046427 9.43 CCL5 IL6
26 negative regulation of neurogenesis GO:0050768 9.4 IL6 TNF
27 positive regulation of chemokine production GO:0032722 9.37 IL6 TNF
28 positive regulation of glial cell proliferation GO:0060252 9.26 IL6 TNF
29 negative regulation of lipid storage GO:0010888 9.16 IL6 TNF
30 positive regulation of neuroinflammatory response GO:0150078 8.96 IL6 TNF
31 positive regulation of smooth muscle cell proliferation GO:0048661 8.8 CCL5 IL6 TNF

Molecular functions related to Scorpion Envenomation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CCL5 IL6 TNF

Sources for Scorpion Envenomation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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