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MCID: SCR039
MIFTS: 38

Scorpion Envenomation

Categories: Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Scorpion Envenomation

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MalaCards integrated aliases for Scorpion Envenomation:

Name: Scorpion Envenomation 58

Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

ICD10 via Orphanet 33 T63.2
Orphanet 58 ORPHA466677
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Summaries for Scorpion Envenomation

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MalaCards based summary : Scorpion Envenomation is related to myocarditis and disseminated intravascular coagulation. An important gene associated with Scorpion Envenomation is IL6 (Interleukin 6), and among its related pathways/superpathways are TNFR1 Pathway and Toll-like Receptor Signaling Pathway. The drugs Midazolam and Prazosin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and lung, and related phenotypes are seizures and dyskinesia

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Related Diseases for Scorpion Envenomation

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Diseases related to Scorpion Envenomation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 456)
# Related Disease Score Top Affiliating Genes
1 myocarditis 30.6 TNF IL6
2 disseminated intravascular coagulation 30.3 TNF IL6
3 urticaria 30.2 TNF IL6
4 exanthem 30.2 TNF IL6
5 respiratory failure 29.8 TNF IL6 CCL5
6 acute pancreatitis 29.7 TNF IL6
7 allergic hypersensitivity disease 29.4 TNF CCL5
8 myocardial infarction 29.0 TNF IL6 CCL5
9 pulmonary edema 10.9
10 cardiogenic shock 10.7
11 ocular motor apraxia 10.5
12 toxic myocarditis 10.4
13 hyperglycemia 10.4
14 paresthesia 10.4
15 atrial standstill 1 10.2
16 stroke, ischemic 10.2
17 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.2
18 metabolic acidosis 10.2
19 cardiac arrest 10.2
20 diarrhea 10.2
21 hypokalemia 10.2
22 priapism 10.2
23 hypertensive encephalopathy 10.2
24 broken heart syndrome 10.2
25 encephalopathy 10.2
26 tremor 10.2
27 conjunctivitis 10.1 TNF IL6
28 external pathological resorption 10.1 TNF IL6
29 myelitis 10.1 TNF IL6
30 idiopathic anterior uveitis 10.1 TNF IL6
31 uveitis 10.1 TNF IL6
32 streptococcal toxic-shock syndrome 10.1 TNF IL6
33 angioimmunoblastic lymphadenopathy with dysproteinemia 10.1 TNF IL6
34 null-cell leukemia 10.1 TNF IL6
35 posterior urethral valves 10.1 TNF IL6
36 post-transplant lymphoproliferative disease 10.1 TNF IL6
37 post-cardiac arrest syndrome 10.1 TNF IL6
38 transverse myelitis 10.1 TNF IL6
39 eales disease 10.1 TNF IL6
40 tracheitis 10.1 TNF IL6
41 carbuncle 10.1 TNF IL6
42 chemical colitis 10.1 TNF IL6
43 heart aneurysm 10.1 TNF IL6
44 aortitis 10.1 TNF IL6
45 coronary aneurysm 10.1 TNF IL6
46 hypopyon 10.1 TNF IL6
47 tenosynovitis 10.1 TNF IL6
48 synovitis 10.1 TNF IL6
49 chondromalacia 10.1 TNF IL6
50 pneumonic tularemia 10.1 TNF IL6

Graphical network of the top 20 diseases related to Scorpion Envenomation:



Diseases related to Scorpion Envenomation
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Symptoms & Phenotypes for Scorpion Envenomation

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Human phenotypes related to Scorpion Envenomation:

58 (show top 50) (show all 58)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 seizures 58 Very rare (<4-1%)
2 dyskinesia 58 Very rare (<4-1%)
3 vomiting 58 Frequent (79-30%)
4 hypokalemia 58 Occasional (29-5%)
5 fever 58 Very rare (<4-1%)
6 hyperhidrosis 58 Occasional (29-5%)
7 arrhythmia 58 Occasional (29-5%)
8 ataxia 58 Very rare (<4-1%)
9 edema 58 Very frequent (99-80%)
10 erythema 58 Very frequent (99-80%)
11 myoclonus 58 Very rare (<4-1%)
12 tremor 58 Occasional (29-5%)
13 hyperreflexia 58 Very rare (<4-1%)
14 congestive heart failure 58 Occasional (29-5%)
15 abdominal pain 58 Frequent (79-30%)
16 hypertension 58 Occasional (29-5%)
17 bundle branch block 58 Very rare (<4-1%)
18 dysarthria 58 Very rare (<4-1%)
19 paresthesia 58 Frequent (79-30%)
20 purpura 58 Occasional (29-5%)
21 stroke 58 Very rare (<4-1%)
22 myocarditis 58 Very rare (<4-1%)
23 restlessness 58 Frequent (79-30%)
24 miosis 58 Frequent (79-30%)
25 tachycardia 58 Very frequent (99-80%)
26 tachypnea 58 Occasional (29-5%)
27 diarrhea 58 Occasional (29-5%)
28 excessive salivation 58 Occasional (29-5%)
29 mydriasis 58 Occasional (29-5%)
30 ketonuria 58 Very rare (<4-1%)
31 hyperglycemia 58 Occasional (29-5%)
32 glycosuria 58 Occasional (29-5%)
33 acute kidney injury 58 Very rare (<4-1%)
34 ventricular extrasystoles 58 Very rare (<4-1%)
35 blurred vision 58 Very rare (<4-1%)
36 pulmonary edema 58 Occasional (29-5%)
37 pain 58 Very frequent (99-80%)
38 hyperkinetic movements 58 Very rare (<4-1%)
39 increased lactate dehydrogenase activity 58 Occasional (29-5%)
40 acute pancreatitis 58 Occasional (29-5%)
41 rhabdomyolysis 58 Very rare (<4-1%)
42 chills 58 Occasional (29-5%)
43 abnormal involuntary eye movements 58 Very rare (<4-1%)
44 hemifacial spasm 58 Very rare (<4-1%)
45 t-wave inversion 58 Occasional (29-5%)
46 abnormality of acid-base homeostasis 58 Occasional (29-5%)
47 cardiogenic shock 58 Occasional (29-5%)
48 cardiac conduction abnormality 58 Frequent (79-30%)
49 respiratory alkalosis 58 Occasional (29-5%)
50 abnormal nasal mucus secretion 58 Occasional (29-5%)
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Drugs & Therapeutics for Scorpion Envenomation

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Drugs for Scorpion Envenomation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 2, Phase 3 59467-70-8 4192
2
Prazosin Approved Phase 3 19216-56-9 4893
3 Antivenins Phase 3
4 Immunologic Factors Phase 3
5 Neurotransmitter Agents Phase 3
6 Adrenergic alpha-Antagonists Phase 3
7 Antihypertensive Agents Phase 3
8 Adrenergic Antagonists Phase 3
9 Adrenergic Agents Phase 3
10 Adrenergic alpha-1 Receptor Antagonists Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Open Label, Confirmatory, Controlled Clinical Study of Alacramyn® in Pediatric Patients With Scorpion Sting Envenomation Completed NCT01599923 Phase 3
2 Open Label, Confirmatory, Controlled Clinical Study of Alacramyn® in Pediatric Patients With Scorpion Sting Envenomation Completed NCT01599936 Phase 3
3 Prospective, Randomized, Double-Blind, Controlled Study of Alacramyn® vs. Placebo in Pediatric Patients With Systemic Signs of Scorpion Sting Envenomation Completed NCT00685230 Phase 2, Phase 3
4 Comparative Study of Efficacy of Antiscorpion Venom Serum(AScVS)vs Prazosin in the Management of Severe Scorpion(Mesobuthus Tamulus Concanesis Pocock)Envenomation and Evaluation of Effects of the Combination of AScVS + Prazosin Therapy. Completed NCT00753064 Phase 3 Antiscorpion venom serum(AScVS).;T.Prazosin;AScVS + Prazosin
5 Phase 2/3 Study for Scorpion North Africa Middle East Envenomation With a Immune F(ab')2 (Equine) Antivenom Alacramyn NAMO. A Randomized, Double-Blind, Placebo-controlled, Prospective and Multicenter Study Completed NCT01336660 Phase 2, Phase 3
6 Treatment Protocol for Use of Anascorp™ in Patients With Scorpion Sting Envenomation Completed NCT00624078 Phase 2, Phase 3 Antivenin Centruroides (scorpion) F(ab)2 Anascorp™
7 Establishment of Natural History of Scorpion Envenomation in the Absence of Antivenom Treatment in Pediatric Patients Completed NCT00696683

Search NIH Clinical Center for Scorpion Envenomation

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Genetic Tests for Scorpion Envenomation

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Anatomical Context for Scorpion Envenomation

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MalaCards organs/tissues related to Scorpion Envenomation:

40
Heart, Kidney, Lung, Eye, Brain, Pancreas, Skin
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Publications for Scorpion Envenomation

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Articles related to Scorpion Envenomation:

(show top 50) (show all 378)
# Title Authors PMID Year
1
Complete neutralization of the lethality of Hemiscorpius lepturus crude venom by a novel anti-recombinant phospholipase D1 IgGs. 61
32445840 2020
2
Dobutamine in the treatment of severe scorpion envenoming. 61
32428515 2020
3
Involvement of the Endothelin Receptor Type A in the Cardiovascular Inflammatory Response Following Scorpion Envenomation. 61
32545475 2020
4
Review of Scorpion Stings and Snakebites Treated by the French Military Health Service During Overseas Operations Between 2015 and 2017. 61
32331950 2020
5
Neurotoxicity of Tityus bahiensis (brown scorpion) venom in sympathetic vas deferens preparations and neuronal cells. 61
32548756 2020
6
Effect of Tityus serrulatus scorpion venom on isolated jejunum: A very useful tool to study the interaction between neurons in the enteric nervous system. 61
32464449 2020
7
Scorpion stings in pregnancy: an analysis of outcomes in 66 envenomed pregnant patients in Iran. 61
32405289 2020
8
Novel Mutant Phospholipase D from Hemiscorpius lepturus Acts as A Highly Immunogen in BALB/c Mice Against the Lethality of Scorpion Venom. 61
32260428 2020
9
Scorpion envenomation: state of the art. 61
32125457 2020
10
Interleukin-1 Receptor-Induced Nitric Oxide Production in the Pancreas Controls Hyperglycemia Caused by Scorpion Envenomation. 61
32150895 2020
11
Is there any relationship between initial hematological parameters and severity of scorpion envenomation? 61
32558413 2020
12
Fatal scorpion envenomation in a 3-month-old infant. 61
31885003 2019
13
Predictors for Mortality in Children with Scorpion Envenomation Admitted to Pediatric Intensive Care Unit, Qena Governorate, Egypt. 61
31407657 2019
14
Black Scorpion (Tityus obscurus) Fatalities in Guyana and a Literature Review. 61
31564443 2019
15
Scorpion envenomation and inflammation: Beyond neurotoxic effects. 61
31228480 2019
16
Evaluation of Scorpion Envenomation by Tityus trivittatus in Adults: An Analysis of Variables Related to Severity of Clinical Presentation. 61
31351826 2019
17
Comparing clinical outcomes between two scorpion antivenom dosing strategies in children. 61
30729820 2019
18
Venoms of Iranian Scorpions (Arachnida, Scorpiones) and Their Potential for Drug Discovery. 61
31340554 2019
19
Protective effect of aqueous extract, fractions and phenolic compounds of Hancornia speciosa fruits on the inflammatory damage in the lungs of mice induced by Tityus serrulatus envenomation. 61
30902683 2019
20
Cerebrospinal inflammatory response following scorpion envenomation: role of histamine H1 and H3 receptors. 61
30604198 2019
21
Scorpion Envenomation to Therapeutics. 61
31064904 2019
22
A randomized comparative study between intravenous and intramuscular scorpion antivenom regimens in children. 61
30664882 2019
23
The epidemiology and severity of scorpion envenoming in South Africa as managed by the Tygerberg Poisons Information Centre over a 10 year period. 61
30873347 2019
24
Evaluation of oxidant/antioxidant status in serum of sheep experimentally envenomated with Hemiscorpius lepturus scorpion venom. 61
31338151 2019
25
[Epidemiology of home accidents in childhood: experience in the Division of General Pediatrics in Southern Tunisia]. 61
31489086 2019
26
Toxicological and epidemiological studies of scorpion sting cases and morphological characterization of scorpions (Leiurusquin questriatus and Androctonus crassicauda) in Luxor, Egypt. 61
31049294 2019
27
Mechanisms of toxic cardiomyopathy. 61
30260248 2019
28
Fatal scorpion envenomation: a case report. 61
31268278 2019
29
Scorpion envenomation: from a neglected to a helpful disease? 61
29846746 2019
30
Study of Factors Contributing to Scorpion Envenomation in Arizona. 61
30488297 2019
31
EP80317 Restrains Inflammation and Mortality Caused by Scorpion Envenomation in Mice. 61
30886580 2019
32
Severe Troponin I Elevation and Myocardial Dysfunction in a Child with Scorpion Sting. 61
31073500 2018
33
Myocarditis and Early Markers of Cardiac Response Associated with Scorpion Stings in Children. 61
30257800 2018
34
Myocardial injury induced by scorpion sting envenoming and evidence of oxidative stress in Egyptian children. 61
30171930 2018
35
Determination of median effective dose (ED50) of scorpion antivenom against scorpion envenomation using a newly developed formula. 61
30891569 2018
36
Efficacy of Scorpion Antivenom in Grade III and IV Scorpion Envenomation. 61
29704171 2018
37
Incidence, mechanisms and impact outcome of hyperglycaemia in severe scorpion-envenomed patients. 61
29977498 2018
38
Value of troponin levels in the diagnosis of cardiac dysfunction in moderate scorpion envenomation. 61
28776390 2018
39
Involvement of Alveolar Macrophages and Neutrophils in Acute Lung Injury After Scorpion Envenomation: New Pharmacological Targets. 61
29492721 2018
40
Management of scorpion envenomation at the Faya-Largeau medical post, February-June, 2014. 61
29799424 2018
41
Inverted Takotsubo syndrome in Androctonus australis scorpion envenomation. 61
28905655 2018
42
A Relationship Between Clinical and Laboratory Characteristics in Children With Severe Scorpion Envenomation in Çukurova, Turkey. 61
29698349 2018
43
Centruroides sculpturatus envenomation in three adult patients requiring treatment with antivenom. 61
28871821 2018
44
New and safe formulation for scorpion immunotherapy: Comparative study between saponin and FCA adjuvants associated to attenuated venom. 61
29483031 2018
45
Update on the Epidemiology of Scorpion Envenomation in the South of Tunisia. 61
29338987 2018
46
Androctonus genus species in arid regions: Ecological niche models, geographical distributions, and envenomation risk. 61
29657418 2018
47
Severe bark scorpion envenomation in adults<sup/>. 61
28753044 2018
48
Evidence of Direct Toxicological Effects of Scorpion Venom on Central Nervous System in Tunisian Children. 61
30425860 2018
49
Acute kidney injury and pancreatitis due to scorpion sting: case report and literature review. 61
29972468 2018
50
Geographic Distribution of Scorpion Exposures in the United States, 2010-2015. 61
29048956 2017
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Variations for Scorpion Envenomation

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Expression for Scorpion Envenomation

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Search GEO for disease gene expression data for Scorpion Envenomation.
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Pathways for Scorpion Envenomation

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Pathways related to Scorpion Envenomation according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
TNFR1 Pathway 63
Show member pathways
 12.71 TNF IL6 CCL5
2
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.71 TNF IL6 CCL5
3
Human cytomegalovirus infection 36
Show member pathways
 12.59 TNF IL6 CCL5
4
Measles 36
Show member pathways
 12.46 TNF IL6 CCL5
5
Herpes simplex virus 1 infection 36
12.43 TNF IL6 CCL5
6
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 11.91 TNF IL6 CCL5
7
Folate Metabolism 1
Show member pathways
 11.88 TNF IL6 CCL5
8
Yersinia infection 36
11.76 TNF IL6
9
NOD-like receptor signaling pathway 36
11.76 TNF IL6 CCL5
10
Spinal Cord Injury 1
11.75 TNF IL6
11
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.74 TNF IL6
12
Interleukin-4 and 13 signaling 65
11.73 TNF IL6
13
Insulin resistance 36
Show member pathways
 11.71 TNF IL6
14
IL27-mediated signaling events 1
Show member pathways
 11.69 TNF IL6
15
Amoebiasis 36
11.66 TNF IL6
16
AGE-RAGE signaling pathway in diabetic complications 36
11.65 TNF IL6
17
Hematopoietic cell lineage 36
11.64 TNF IL6
18
Pertussis 36
11.52 TNF IL6
19
Dendritic Cells Developmental Lineage Pathway 64
11.5 TNF IL6
20
TNF signaling pathway 36
11.48 TNF IL6 CCL5
21
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.43 TNF IL6
22
Legionellosis 36
11.38 TNF IL6
23
Photodynamic therapy-induced AP-1 survival signaling. 1
11.32 TNF IL6
24
Malaria 36
11.3 TNF IL6
25
Rheumatoid arthritis 36
11.3 TNF IL6 CCL5
26
amb2 Integrin signaling 1
11.28 TNF IL6
27
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.24 TNF IL6
28
African trypanosomiasis 36
11.13 TNF IL6
29
Prion diseases 36
11.09 IL6 CCL5
30
IL-10 Pathway 63
11.08 TNF IL6
31
Development and heterogeneity of the ILC family 1
11.03 TNF IL6
32
Antifolate resistance 36
11 TNF IL6
33
Cytokines and Inflammatory Response 1
10.96 TNF IL6
34
Lung fibrosis 1
10.93 TNF IL6 CCL5
35
EBV LMP1 signaling 1
10.86 TNF CCL5
36
Transcription factor regulation in adipogenesis 1
10.8 TNF IL6
37
Overview of nanoparticle effects 1
10.71 TNF IL6
38
G-protein signaling_Rap2B regulation pathway 22
10.67 TNF IL6 CCL5
39
Interleukin-10 signaling 65
10.49 TNF IL6 CCL5
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GO Terms for Scorpion Envenomation

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Biological processes related to Scorpion Envenomation according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.72 TNF IL6 CCL5
2 inflammatory response GO:0006954 9.69 TNF IL6 CCL5
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.65 TNF IL6
4 defense response to Gram-positive bacterium GO:0050830 9.64 TNF IL6
5 response to virus GO:0009615 9.64 TNF CCL5
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.63 TNF IL6
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.63 TNF CCL5
8 regulation of insulin secretion GO:0050796 9.62 TNF CCL5
9 cellular response to organic cyclic compound GO:0071407 9.62 TNF CCL5
10 response to glucocorticoid GO:0051384 9.61 TNF IL6
11 positive regulation of T cell proliferation GO:0042102 9.61 IL6 CCL5
12 humoral immune response GO:0006959 9.6 TNF IL6
13 positive regulation of interleukin-6 production GO:0032755 9.59 TNF IL6
14 positive regulation of cell adhesion GO:0045785 9.58 TNF CCL5
15 negative regulation of fat cell differentiation GO:0045599 9.58 TNF IL6
16 cytokine-mediated signaling pathway GO:0019221 9.58 TNF IL6 CCL5
17 monocyte chemotaxis GO:0002548 9.57 IL6 CCL5
18 negative regulation of viral genome replication GO:0045071 9.56 TNF CCL5
19 protein kinase B signaling GO:0043491 9.54 TNF CCL5
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.52 TNF CCL5
21 negative regulation of neurogenesis GO:0050768 9.49 TNF IL6
22 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.48 TNF IL6
23 positive regulation of chemokine production GO:0032722 9.46 TNF IL6
24 positive regulation of glial cell proliferation GO:0060252 9.43 TNF IL6
25 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.37 TNF IL6
26 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.33 TNF IL6 CCL5
27 positive regulation of neuroinflammatory response GO:0150078 9.32 TNF IL6
28 negative regulation of lipid storage GO:0010888 9.26 TNF IL6
29 positive regulation of smooth muscle cell proliferation GO:0048661 9.13 TNF IL6 CCL5
30 positive regulation of JAK-STAT cascade GO:0046427 8.8 TNF IL6 CCL5

Molecular functions related to Scorpion Envenomation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 TNF IL6 CCL5
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Sources for Scorpion Envenomation

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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