MCID: SCR039
MIFTS: 34

Scorpion Envenomation

Categories: Rare diseases

Aliases & Classifications for Scorpion Envenomation

MalaCards integrated aliases for Scorpion Envenomation:

Name: Scorpion Envenomation 59

Classifications:



External Ids:

Orphanet 59 ORPHA466677
ICD10 via Orphanet 34 T63.2

Summaries for Scorpion Envenomation

MalaCards based summary : Scorpion Envenomation is related to myocardial infarction and leukomalacia. An important gene associated with Scorpion Envenomation is IL6 (Interleukin 6), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Midazolam and Prazosin have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, lung and brain.

Related Diseases for Scorpion Envenomation

Diseases related to Scorpion Envenomation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
# Related Disease Score Top Affiliating Genes
1 myocardial infarction 28.8 CCL5 IL6 TNF
2 leukomalacia 10.3 IL6 TNF
3 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL6 TNF
4 critical limb ischemia 10.3 IL6 TNF
5 streptococcal toxic-shock syndrome 10.3 IL6 TNF
6 null-cell leukemia 10.3 IL6 TNF
7 retinitis pigmentosa 55 10.3 IL6 TNF
8 anca-associated vasculitis 10.3 IL6 TNF
9 laryngitis 10.3 IL6 TNF
10 acute vascular insufficiency of intestine 10.3 IL6 TNF
11 posterior urethral valves 10.3 IL6 TNF
12 poems syndrome 10.3 IL6 TNF
13 microscopic colitis 10.3 IL6 TNF
14 meconium aspiration syndrome 10.3 IL6 TNF
15 burning mouth syndrome 10.3 IL6 TNF
16 central nervous system vasculitis 10.3 IL6 TNF
17 osteosclerotic myeloma 10.3 IL6 TNF
18 louse-borne relapsing fever 10.3 IL6 TNF
19 listeriosis 10.3 IL6 TNF
20 transverse myelitis 10.3 IL6 TNF
21 ischemic heart disease 10.3 IL6 TNF
22 crimean-congo hemorrhagic fever 10.3 IL6 TNF
23 intermediate uveitis 10.2 IL6 TNF
24 monoclonal gammopathy of uncertain significance 10.2 IL6 TNF
25 post-transplant lymphoproliferative disease 10.2 IL6 TNF
26 eales disease 10.2 IL6 TNF
27 hemorrhagic fever 10.2 IL6 TNF
28 myelitis 10.2 IL6 TNF
29 stromal keratitis 10.2 IL6 TNF
30 hematopoietic stem cell transplantation 10.2 IL6 TNF
31 endometritis 10.2 IL6 TNF
32 rosacea 10.2 IL6 TNF
33 systolic heart failure 10.2 IL6 TNF
34 joint disorders 10.2 IL6 TNF
35 pulpitis 10.2 IL6 TNF
36 localized scleroderma 10.2 IL6 TNF
37 plasmodium vivax malaria 10.2 IL6 TNF
38 periventricular leukomalacia 10.2 IL6 TNF
39 apnea, obstructive sleep 10.2 IL6 TNF
40 commensal bacterial infectious disease 10.2 IL6 TNF
41 lacrimal apparatus disease 10.2 IL6 TNF
42 adult-onset still's disease 10.2 IL6 TNF
43 perinatal necrotizing enterocolitis 10.2 IL6 TNF
44 aphthous stomatitis 10.2 IL6 TNF
45 fasciitis 10.2 IL6 TNF
46 ileitis 10.2 IL6 TNF
47 rasmussen encephalitis 10.2 IL6 TNF
48 dengue shock syndrome 10.2 IL6 TNF
49 infective endocarditis 10.2 IL6 TNF
50 hemorrhagic fever with renal syndrome 10.2 IL6 TNF

Graphical network of the top 20 diseases related to Scorpion Envenomation:



Diseases related to Scorpion Envenomation

Symptoms & Phenotypes for Scorpion Envenomation

Drugs & Therapeutics for Scorpion Envenomation

Drugs for Scorpion Envenomation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 2, Phase 3 59467-70-8 4192
2
Prazosin Approved Phase 3 19216-56-9 4893
3 Adrenergic Agents Phase 3
4 Adrenergic alpha-1 Receptor Antagonists Phase 3
5 Adrenergic alpha-Antagonists Phase 3
6 Adrenergic Antagonists Phase 3
7 Neurotransmitter Agents Phase 3
8 Antihypertensive Agents Phase 3
9 Antivenins Phase 3,Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial to Compare Two Anti-scorpion Serums Completed NCT00739440 Phase 4
2 AScVS and/ or Prazosin for Scorpion Envenomation Completed NCT00753064 Phase 3 Antiscorpion venom serum(AScVS).;T.Prazosin;AScVS + Prazosin
3 Open Label Clinical Trial of Anascorp® in Pediatric Patients With Scorpion Sting Envenomation Completed NCT01599936 Phase 3
4 Open Label Study of Alacramyn® in Pediatric Patients With Scorpion Sting Envenomation Completed NCT01599923 Phase 3
5 Double-Blind, Alacramyn® vs. Placebo in Pediatric Patients Completed NCT00685230 Phase 2, Phase 3
6 Compare Two Anti-Scorpion Venom Serum In Children Completed NCT01415830 Phase 3
7 Treatment Protocol for Use of Anascorp™ in Patients With Scorpion Sting Envenomation Completed NCT00624078 Phase 2, Phase 3 Antivenin Centruroides (scorpion) F(ab)2 Anascorp™
8 A Trial of Equine F (ab')2 Antivenom for Treatment of Scorpion Envenomation in Morocco Not yet recruiting NCT01336660 Phase 2, Phase 3
9 Establishment of Natural History of Scorpion Envenomation Completed NCT00696683

Search NIH Clinical Center for Scorpion Envenomation

Genetic Tests for Scorpion Envenomation

Anatomical Context for Scorpion Envenomation

MalaCards organs/tissues related to Scorpion Envenomation:

41
Neutrophil, Lung, Brain

Publications for Scorpion Envenomation

Articles related to Scorpion Envenomation:

(show all 40)
# Title Authors Year
1
Management of scorpion envenomation at the Faya-Largeau medical post, February-June, 2014. ( 29799424 )
2018
2
A Relationship Between Clinical and Laboratory Characteristics in Children With Severe Scorpion Envenomation in A8ukurova, Turkey. ( 29698349 )
2018
3
Update on the Epidemiology of Scorpion Envenomation in the South of Tunisia. ( 29338987 )
2018
4
Involvement of Alveolar Macrophages and Neutrophils in Acute Lung Injury After Scorpion Envenomation: New Pharmacological Targets. ( 29492721 )
2018
5
Efficacy of Scorpion Antivenom in Grade III and IV Scorpion Envenomation. ( 29704171 )
2018
6
Scorpion envenomation: from a neglected to a helpful disease? ( 29846746 )
2018
7
Inverted Takotsubo syndrome in Androctonus australis scorpion envenomation. ( 28905655 )
2017
8
Epidemiological and clinical characteristics of scorpionism in Shiraz (2012-2016); development of a clinical severity grading for Iranian scorpion envenomation. ( 29445656 )
2017
9
Successful Use of Extracorporeal Membrane Oxygenation for the Treatment of Cardiogenic Shock due to Scorpion Envenomation. ( 28536661 )
2017
10
Severe scorpion envenomation: pathophysiology and the role of inflammation in multiple organ failure. ( 28655685 )
2017
11
Severe bark scorpion envenomation in adults(). ( 28753044 )
2017
12
Reactogenicity and safety assessment of an attenuated nanovaccine against scorpion envenomation: Preclinical study. ( 29061347 )
2017
13
Value of troponin levels in the diagnosis of cardiac dysfunction in moderate scorpion envenomation. ( 28776390 )
2017
14
A Stinging Suspicion Something Was Just Not Right: Methamphetamine Toxicity in Infant Mimics Scorpion Envenomation. ( 29095780 )
2017
15
Cost Minimization Analysis of Different Strategies of Management of Clinically Significant Scorpion Envenomation Among Pediatric Patients. ( 27749795 )
2016
16
Scorpion envenomation-induced acute thrombotic inferior myocardial infarction. ( 26875137 )
2016
17
The scorpion envenomation in the region of Faouar-KEBILI at 2010-2012 : study of 421 cases. ( 27532524 )
2016
18
Scorpion Envenomation in Pregnancy. ( 27255088 )
2016
19
EPIDEMIOLOGY OF SCORPION ENVENOMATION IN THE STATE OF CEARA8, NORTHEASTERN BRAZIL. ( 27007558 )
2016
20
Venom conjugated polylactide applied as biocompatible material for passive and active immunotherapy against scorpion envenomation. ( 26902547 )
2016
21
Clinical Presentation and Outcomes Associated with Different Treatment Modalities for Pediatric Bark Scorpion Envenomation. ( 27487782 )
2016
22
Scorpion envenomation cardiomyopathy: a promising model for takotsubo syndrome. ( 26135709 )
2015
23
Assessing and managing spider and scorpion envenomation. ( 26542925 )
2015
24
The first description of cardiac magnetic resonance findings in a severe scorpion envenomation: Is it a stress-induced (Takotsubo) cardiomyopathy like? ( 25601163 )
2015
25
Predictive Factors for Determining the Clinical Severity of Pediatric Scorpion Envenomation Cases in Southeastern Turkey. ( 26432426 )
2015
26
Epidemiological and Clinical Characteristics and Outcomes of Scorpion Envenomation in Hospitalized Children in Adiyaman, Turkey. ( 26199687 )
2015
27
Should dobutamine be used in severe scorpion envenomation. ( 26059736 )
2015
28
Managing scorpion envenomation in children. ( 25532976 )
2015
29
Evolution of the electrocardiogram QRS complexes voltage in scorpion envenomation-induced Takotsubo syndrome. ( 25842284 )
2015
30
Scorpion envenomation. ( 25317885 )
2014
31
Scorpion envenomation. ( 25317886 )
2014
32
Scorpion envenomation. ( 25317887 )
2014
33
Scorpion envenomation. ( 25317888 )
2014
34
Lethal brain edema, shock, and coagulopathy after scorpion envenomation. ( 23280335 )
2013
35
Pulmonary edema following scorpion envenomation: mechanisms, clinical manifestations, diagnosis and treatment. ( 22075406 )
2013
36
Serum levels of IL-6 and its soluble receptor, TNF-alpha and chemokine RANTES in scorpion envenomed children: their relation to scorpion envenomation outcome. ( 16466762 )
2006
37
Significance of assessment of serum cardiac troponin I and interleukin-8 in scorpion envenomed children. ( 12565731 )
2003
38
Myocardial injury in scorpion envenomed children: significance of assessment of serum troponin I and interleukin-8. ( 12011799 )
2002
39
Serum interleukin-1beta, interleukin-6, nitric oxide and alpha1-antitrypsin in scorpion envenomed children. ( 9839669 )
1998
40
Vasodilators and hypertensive encephalopathy following scorpion envenomation in children. ( 2295229 )
1990

Variations for Scorpion Envenomation

Expression for Scorpion Envenomation

Search GEO for disease gene expression data for Scorpion Envenomation.

Pathways for Scorpion Envenomation

Pathways related to Scorpion Envenomation according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 CCL5 IL6 TNF
2
Show member pathways
12.91 CCL5 IL6 TNF
3
Show member pathways
12.65 CCL5 IL6 TNF
4
Show member pathways
12.52 CCL5 IL6 TNF
5
Show member pathways
12.43 CCL5 IL6 TNF
6
Show member pathways
12.39 CCL5 IL6 TNF
7
Show member pathways
11.98 IL6 TNF
8
Show member pathways
11.93 IL6 TNF
9
Show member pathways
11.92 IL6 TNF
10
Show member pathways
11.89 IL6 TNF
11 11.89 IL6 TNF
12 11.88 IL6 TNF
13
Show member pathways
11.83 CCL5 IL6 TNF
14 11.78 IL6 TNF
15 11.74 IL6 TNF
16 11.72 IL6 TNF
17 11.71 IL6 TNF
18
Show member pathways
11.68 IL6 TNF
19 11.64 IL6 TNF
20 11.62 IL6 TNF
21 11.62 IL6 TNF
22 11.51 IL6 TNF
23 11.49 IL6 TNF
24 11.47 CCL5 IL6 TNF
25
Show member pathways
11.41 IL6 TNF
26 11.35 IL6 TNF
27 11.31 IL6 TNF
28 11.29 CCL5 IL6 TNF
29 11.28 IL6 TNF
30 11.27 IL6 TNF
31 11.23 IL6 TNF
32 11.08 IL6 TNF
33 11.07 IL6 TNF
34 11.05 CCL5 IL6
35 11 IL6 TNF
36 10.97 IL6 TNF
37 10.93 IL6 TNF
38 10.93 CCL5 IL6 TNF
39 10.81 CCL5 TNF
40 10.75 IL6 TNF
41 10.65 IL6 TNF
42 10.49 CCL5 IL6 TNF

GO Terms for Scorpion Envenomation

Biological processes related to Scorpion Envenomation according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.63 IL6 TNF
2 cellular response to lipopolysaccharide GO:0071222 9.63 IL6 TNF
3 immune response GO:0006955 9.63 CCL5 IL6 TNF
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.62 IL6 TNF
5 response to virus GO:0009615 9.62 CCL5 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.61 IL6 TNF
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.61 IL6 TNF
8 regulation of signaling receptor activity GO:0010469 9.61 CCL5 IL6 TNF
9 cellular response to organic cyclic compound GO:0071407 9.6 CCL5 TNF
10 regulation of insulin secretion GO:0050796 9.59 CCL5 TNF
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 CCL5 IL6
12 response to glucocorticoid GO:0051384 9.58 IL6 TNF
13 positive regulation of T cell proliferation GO:0042102 9.57 CCL5 IL6
14 humoral immune response GO:0006959 9.56 IL6 TNF
15 positive regulation of interleukin-6 production GO:0032755 9.55 IL6 TNF
16 positive regulation of cell adhesion GO:0045785 9.54 CCL5 TNF
17 inflammatory response GO:0006954 9.54 CCL5 IL6 TNF
18 negative regulation of fat cell differentiation GO:0045599 9.52 IL6 TNF
19 protein kinase B signaling GO:0043491 9.51 CCL5 TNF
20 monocyte chemotaxis GO:0002548 9.49 CCL5 IL6
21 negative regulation of viral genome replication GO:0045071 9.48 CCL5 TNF
22 cytokine-mediated signaling pathway GO:0019221 9.43 CCL5 IL6 TNF
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.4 CCL5 TNF
24 positive regulation of JAK-STAT cascade GO:0046427 9.32 CCL5 IL6
25 positive regulation of chemokine production GO:0032722 9.16 IL6 TNF
26 negative regulation of lipid storage GO:0010888 8.96 IL6 TNF
27 positive regulation of smooth muscle cell proliferation GO:0048661 8.8 CCL5 IL6 TNF

Molecular functions related to Scorpion Envenomation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CCL5 IL6 TNF

Sources for Scorpion Envenomation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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